CN104374902A - Self-damp-proof test chip and manufacturing method thereof - Google Patents

Self-damp-proof test chip and manufacturing method thereof Download PDF

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Publication number
CN104374902A
CN104374902A CN201410003629.1A CN201410003629A CN104374902A CN 104374902 A CN104374902 A CN 104374902A CN 201410003629 A CN201410003629 A CN 201410003629A CN 104374902 A CN104374902 A CN 104374902A
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China
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corpse
checking chip
sheet
laboratory examination
chemical testing
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CN201410003629.1A
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Chinese (zh)
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廖肇清
刘炜煦
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TONYAR BIOTECH Inc
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TONYAR BIOTECH Inc
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Publication of CN104374902A publication Critical patent/CN104374902A/en
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Packages (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention relates to an autologous moisture-proof test chip and a manufacturing method thereof. The self-damp-proof test chip mainly comprises a sheet butt-joint mat pad with a first end and a second end, a sample pad for receiving infiltration of a test body, a reactant release pad with a reactant corresponding to the test body, a result display pad for displaying the reaction result of the reactant of the test body, and a water body absorption sheet which is arranged in sequence, wherein the water body absorption sheet mainly comprises an agent capable of absorbing water.

Description

The checking chip of autologous protection against the tide and manufacture method thereof
Technical field
The present invention relates to a kind of checking chip and manufacture method thereof, espespecially the checking chip of the autologous dehumidifying moisture protection of tool and manufacture method thereof.
Background technology
In recent years, due to the prosperity of medical equipment technology, make home-use physiological signal measuring instrument more and more general.Such as, sphygmomanometer, electronic thermometer, blood-glucose meter, uric acid monitoring meter, cholesterol test meter, mini electrocardiograph etc.Different physiological signal measuring instruments, its price is different, and practicality is also different.
Some physiological signal measuring instrument, blood must be gathered measure, therefore, the medical test paper having included ferment must be adopted to measure, such as the test of blood sugar, uric acid, T-CHOL, low-density lipoprotein, high-density lipoprotein (HDL), liver function index, triglyceride etc.Although adopt the instrument of medical test paper, it is preserved and safeguards quite easily, and medical test paper itself is not easy to preserve.
Medical test paper is difficult to the reason of preserving, and is the ferment in medical test paper, can be hydrolyzed, cause medical test paper to lose efficacy because of the aqueous vapor absorbed in air.Therefore, medical test paper itself needs to preserve through the medical test paper bottle or package body material with excellent sealing effect, must place dry bag in addition in even medical test paper bottle or package body material.
But the cost of medical test paper bottle package body is higher, and once after uncork all medical test paper all will face the problem of making moist, user must finish using within certain time limit, or change and deposited in proof cabinet, but this can become again necessary collective custody, use problem not easily.
TaiWan, China patent announcement M419571 " capsule-type medical test paper packaging " proposes the medical test paper packaging of a kind of capsule-type, comprises base material, at least one desiccant layer and at least one medical test paper.Wherein, described base material comprises multiple capsule structure, and each capsule structure comprises an observation window; Described desiccant layer adopts the metachroic material of moisture absorption, and be the inside surface being arranged at each capsule structure.But though can easy observation to make moist situation, such wrappage cost will significantly improve.
Other more common package bodies are then the drying agent being simultaneously placed as bag-like in package body material, but can cost be increased like this, and the content space of this package body must meet the volume of this drying agent material bag, the body of package body is increased, the bodily form of package body more cannot be made cannot to obtain close ratio with the bodily form of test piece, make to take to push away and deposit space.
Summary of the invention
Fundamental purpose of the present invention is providing a kind of before package body is enabled, there is checking chip and the manufacture method thereof of autologous moisture protection, main utilization receives sheet primarily of the water body that the element of moisture can be received to form, the ability of drawing is drawn except utilizing it, and water absorptivity provides and receives this corpse or other object for laboratory examination and chemical testing raffinate, and encapsulating enable before, aqueous vapor that can be residual in checking chip surrounding air in absorbed themselves package body, to reach the maintenance of checking chip aridity, solve complex process in prior art, increase the problems such as the high expensive of dehumidifying section, and this water body receives sheet to be assemble with each component synchronization, the checking chip promoting the autologous moisture protection of tool is produced and packaging speed, the bodily form that simultaneously also can reduce package body makes it to encapsulate close to the exquisiteness of the test piece bodily form.
Based on above-mentioned purpose, in checking chip of the present invention and manufacture method thereof, checking chip mainly comprises the sheet with first end and the second end and flushes straw mats, in order to accepting sample pad that a corpse or other object for laboratory examination and chemical testing infiltrates, has the result discharging the reaction result of this reactive material padding, present this corpse or other object for laboratory examination and chemical testing relative to the reactant of the reactive material of this corpse or other object for laboratory examination and chemical testing and show and to pad and water body receives the arrangement of sheet sequence to combine.Water body receives sheet to form primarily of receiving the agent material of moisture, there is provided to utilize its water absorptivity and corpse or other object for laboratory examination and chemical testing superfluous water liquid is drawn, and Kaifeng enable before, remaining aqueous vapor in this checking chip surrounding air of body absorption can packed, to avoid checking chip moisture damage, simultaneously because of the element that water body receives sheet originally necessary, therefore number of elements can not be increased, reduce or remit on the contrary and commonly in package body preserve identical drying agent material bag with medicament, therefore reduce costs.
Still a further object of the present invention receives sheet for this water body, can adopt by hydrophilic fibers be made into is three-dimensional block or plates, wherein being mixed with can the drying material of moisture absorption, it mixes and can be Sandwich filling, or with hydrophilic fibers chemical combination before becoming silk, being mainly can ingress of air, and beginning can residual moisture in air in draw package body.
The present invention once more an object for produce time, be arranged to rectilinearity production line, according to the travel line flushing straw mats, the team of tabular thereon of parallel constant speed is synchronously combined with the sample pad of material strip shape, release pad, display pad and water body and receives sheet, after combination before the terminal of travel line, be provided with cutting means, and do to depend on to finished width according to cutting dynamic frequency change.
For achieving the above object, the invention provides a kind of checking chip of autologous protection against the tide, comprising:
One sample pad, in order to accept the infiltration of a corpse or other object for laboratory examination and chemical testing;
One reactant release pad, end thereof contacts to this sample pad, and has the reactive material relative to this corpse or other object for laboratory examination and chemical testing;
One result display pad, end thereof contacts pads to the release of this reactant, and in order to the reaction result of this reactive material of presenting this corpse or other object for laboratory examination and chemical testing; And
One water body receives sheet, end thereof contacts is to this result display pad, this agent material receiving sheet to receive primarily of tool water body formed, there is capillary effect, footpath at least conducting result display pad indirectly of leading the way is drawn via one, there is provided and gravitation is drawn to the capillary flow of this corpse or other object for laboratory examination and chemical testing, and at least under encapsulated state, the aqueous vapor around this checking chip of simultaneously stability in package body in air.
In the checking chip of above-mentioned autologous protection against the tide, preferably, at least receive to set up between sheet and described sample pad at described water body and draw footpath of leading the way, receive the water absorptivity of sheet to provide the capillary flow of this corpse or other object for laboratory examination and chemical testing to draw gravitation to utilize this water body.
In the checking chip of above-mentioned autologous protection against the tide, preferably, described water body receives sheet to have geometry three-dimensional shape, and the aqueous vapor in this checking chip surrounding air of Absorbable rod.
Present invention also offers the checking chip of another kind of autologous protection against the tide, comprise:
One sheet flushes straw mats, has first end and the second end;
One sample pad, is formed on the first end that this flushes straw mats, and in order to accept the infiltration of a corpse or other object for laboratory examination and chemical testing;
One reactant release pad, is formed on this and flushes on straw mats and to touch this sample pad, and have the reactive material relative to this corpse or other object for laboratory examination and chemical testing;
One result display pad, is formed on this and flushes on straw mats and to touch this reactant release pad, and in order to the reaction result of this reactive material of presenting this corpse or other object for laboratory examination and chemical testing; And
One water body receives sheet, be formed on this second end flushing straw mats and touch this result display pad, and formed primarily of the drying agent material that tool water body receives, there is capillary effect, with the capillary flow attractive force utilizing water absorptivity to provide this corpse or other object for laboratory examination and chemical testing, at least absorb the aqueous vapor in this checking chip package body in surrounding air simultaneously.
In the checking chip of above-mentioned autologous protection against the tide, preferably, at least receive to set up between sheet and described sample pad at described water body and draw footpath of leading the way, receive the water absorptivity of sheet to provide the capillary flow attractive force of a described corpse or other object for laboratory examination and chemical testing to utilize described water body.
In the checking chip of above-mentioned autologous protection against the tide, preferably, described water body receives sheet to have geometry three-dimensional shape, and the aqueous vapor in this checking chip surrounding air of Absorbable rod.
In the checking chip of above-mentioned autologous protection against the tide, preferably, described water body receives sheet to be sheet drying agent, overlay film drying agent or dry paper.
In the checking chip of above-mentioned autologous protection against the tide, preferably, the external packing of checking chip can be cassette (Cassette) structure, itemize formula, pen type (Midstream) structure, chip semi-manufacture, volume structure formula semi-manufacture or capsule-type.
Present invention also offers a kind of manufacture method of checking chip of autologous protection against the tide, comprise:
There is provided there is first end and the second end one flush straw mats material strip; And
Receiving sheet to be sequentially combined in this in sample bedding and padding band, a reactant release bedding and padding band, a result display bedding and padding band, a banded water body flushes on straw mats material strip, to form the banded checking chip do not cut;
Wherein, in this banded checking chip, this sample pad material strip is bonded to the first end that this flushes straw mats material strip, and the infiltration of a corpse or other object for laboratory examination and chemical testing can be accepted with this sample pad material strip, this reactant release bedding and padding are with touching this sample pad material strip, and this reactant release bedding and padding band has the reactive material relative to this corpse or other object for laboratory examination and chemical testing, this result display bedding and padding are with touching this reactant release pad, and this result display bedding and padding band can present the reaction result of this reactive material of this corpse or other object for laboratory examination and chemical testing, this banded water body receives sheet to touch this result display bedding and padding band, and this banded water body receives sheet to form primarily of drying agent material, with the capillary flow attractive force utilizing water absorptivity to provide this corpse or other object for laboratory examination and chemical testing, aqueous vapor in this checking chip surrounding air of simultaneously stability.
In above-mentioned manufacture method, preferably, this manufacture method comprises further:
This banded checking chip do not cut, and form multiple shape checking chip.
Accompanying drawing explanation
Fig. 1 is the schematic diagram of the checking chip of the autologous protection against the tide of the present invention.
Fig. 2 is the schematic diagram of the manufacture method of the checking chip of the autologous protection against the tide of the present invention.
Main Reference label declaration:
The checking chip (Lateral flow test strip) of 1 autologous protection against the tide
10 flush straw mats (Adhesive card)
101 first ends
102 second ends
20 sample pad (Sample pad)
30 reactants release pad (Conjugated pad)
40 results display pad (Membrane)
50 water bodys receive sheet (Absorbent pad)
51 draw footpath of leading the way
100 flush straw mats material strip
200 sample pad material strips
300 reactant release bedding and padding bands
400 result display bedding and padding bands
500 banded water bodys receive sheet
600 package bodies
7 cutting means
Embodiment
In order to there be understanding clearly to technical characteristic of the present invention, object and beneficial effect, existing following detailed description is carried out to technical scheme of the present invention, but can not be interpreted as to of the present invention can the restriction of practical range.
Refer to Fig. 1, Fig. 1 is the diagrammatic cross-section of the checking chip of the autologous protection against the tide of the present invention.As shown in Figure 1, at the checking chip 1(Lateral flow test strip of the autologous protection against the tide of the present invention) mainly comprise there is first end 101 and the second end 102 flush straw mats 10(Adhesive card), in order to accepting sample pad 20 that a corpse or other object for laboratory examination and chemical testing infiltrates, have and show pad 40 relative to the result that the reactant of the reactive material of a corpse or other object for laboratory examination and chemical testing discharges pad 30, present the reaction result of the reactive material of a corpse or other object for laboratory examination and chemical testing and water body receives sheet 50.
This wherein, sample pad 20 is formed on the first end 101 flushing straw mats 10; Reactant release 30, pad is formed on and flushes on straw mats 10 and touch sample pad 20; Result display pad 40 is formed on and flushes on straw mats 10 and touch reactant release pad 30; Water body receives sheet 50 to be formed on to flush the second end 102 of straw mats 10 and draws via the two conducting footpath 51 of leading the way, make by the unnecessary water liquid of sample pad 20 seepage flow, can be received and receive sheet 50 into water body along drawing footpath 51 of leading the way, so this draws footpath 51 of leading the way is at least receive sheet 50 and result to show both pads 40 by water body to contact and combine.
When a corpse or other object for laboratory examination and chemical testing is instilled from sample pad 20, because water body receives sheet 50 to form primarily of receiving the agent material of water body, therefore water body receives sheet 50 can mainly utilize water absorptivity to provide corpse or other object for laboratory examination and chemical testing path corresponding thereto, form capillary flow and draw gravitation, and allow a corpse or other object for laboratory examination and chemical testing diffuse to result display pad 40 gradually, and in this process, what allow a corpse or other object for laboratory examination and chemical testing and reactant discharge to have in pad 30 reacts relative to the reactive material of this corpse or other object for laboratory examination and chemical testing, and then according to checking chip 1 design originally, demonstrate reaction result (being such as with coloured strip) at result display pad 40.
Be attracted smoothly to allow a corpse or other object for laboratory examination and chemical testing, at least receive sheet 50 and result to show to set up between pad 40 at water body and draw footpath 51 of leading the way, the water absorptivity of sheet 50 is received to provide the capillary flow attractive force of this corpse or other object for laboratory examination and chemical testing to utilize water body, and the water body of indication receives sheet 50, its material formed, be mainly have absorptive macromolecular compound form the bulk of stereo structure, plates etc., the inscape of this stereo structure need have the requirement of siphon capillarity, and with filament weaving, right water molecules fills in fibre gap for adopting, or with interlayer compound, or before being blended in fiber axis, chemical combination is at sizing material, and can contact with surrounding air, and adsorb the undue aqueous vapor that package body 600 packs rear internal residual.
The independent drying material be wrapped up together is attached in package body material by mode in order to save former times, solve the problem such as complex process, high expensive in prior art, water body receives sheet 50 also the aqueous vapor in this checking chip 1 surrounding air of simultaneously stability can to become and provide an applicable pattern in the protection against the tide mechanism of the products such as class.
It is another that water body receives sheet 50 to have geometry three-dimensional shape on the implementation, and the aqueous vapor in this checking chip 1 surrounding air of Absorbable rod, as bulk, sheet, strip etc.
Water body receive sheet 50 can class as being sheet drying agent, overlay film drying agent or dry paper.Water body receives on the material selection of sheet 50 again, one in following group or its combination in any can be comprised with the part of dehumidification function: (1) can with the compound of water reaction, such as: lime chloride, calcium oxide, phosphoric anhydride, (2) there is the material of high-hydroscopicity, such as: silica gel, high molecular polymer, sugarcane fibre, smectite, acticarbon.
That receives sheet 50 to provide water body makes full use of pattern, the checking chip 1 of autologous protection against the tide also can be installed with coated housing, and the covered shell of checking chip 1 can be the shell of cassette (Cassette) structure or pen type (Midstream) structure, and water body receives the shape of sheet 50, can be the strip chip of itemize formula, or sheet is block, or volume structure shape finished product to be cut.
Refer to Fig. 2, Fig. 2 is the schematic diagram of the manufacture method of the checking chip of the autologous protection against the tide of the present invention.As shown in Figure 2, in the manufacture method of the checking chip of the autologous protection against the tide of the present invention, first provide there is first end 101 and the second end 102 flush straw mats material strip 100, then 100 are received sheet 500 to be sequentially formed in sample pad material strip 200, reactant release bedding and padding band 300, result display bedding and padding band 400, banded water body to flush on straw mats material strip, to form the banded checking chip (Uncut lateral flow test sheet) do not cut.Then, multiple checking chip 1 for cutting shape is formed through cutting.Finished goods is packed by package body 600 by the checking chip 1 after cutting or volume structure formula semi-manufacture, this package body operation, and also comprising checking chip 1 is packaging after being mounted into card casket or an examination shell.
Wherein, in the banded checking chip do not cut, sample pad material strip 200 is formed on the first end 101 flushing straw mats material strip 100, and can accept the infiltration of a corpse or other object for laboratory examination and chemical testing with sample pad material strip 100.Reactant release bedding and padding band 200 touches sample pad material strip 200.Reactant release bedding and padding band 300 has the reactive material relative to a corpse or other object for laboratory examination and chemical testing.Result display bedding and padding band 400 touches reactant release, and result display bedding and padding band 400 can present the reaction result of this reactive material of this corpse or other object for laboratory examination and chemical testing.Banded water suction moisture absorption 500 touches this result display pad, and banded water body receives sheet 500 to receive agent material to form primarily of water body, the capillary flow of this corpse or other object for laboratory examination and chemical testing is provided to draw gravitation to utilize water absorptivity, checking chip 1 is under being in and pushing away old encapsulated state, in simultaneously stability package body, the aqueous vapor in this checking chip 1 surrounding air.

Claims (10)

1. a checking chip for autologous protection against the tide, comprises:
One sample pad, in order to accept the infiltration of a corpse or other object for laboratory examination and chemical testing;
One reactant release pad, end thereof contacts to this sample pad, and has the reactive material relative to this corpse or other object for laboratory examination and chemical testing;
One result display pad, end thereof contacts pads to the release of this reactant, and in order to the reaction result of this reactive material of presenting this corpse or other object for laboratory examination and chemical testing; And
One water body receives sheet, end thereof contacts is to this result display pad, this agent material receiving sheet to receive primarily of tool water body formed, there is capillary effect, footpath at least conducting result display pad indirectly of leading the way is drawn via one, there is provided and gravitation is drawn to the capillary flow of this corpse or other object for laboratory examination and chemical testing, and at least under encapsulated state, the aqueous vapor around this checking chip of simultaneously stability in package body in air.
2. the checking chip of autologous protection against the tide as claimed in claim 1, wherein, at least receives to set up between sheet and described sample pad at described water body and draws footpath of leading the way, receive the water absorptivity of sheet to provide the capillary flow of a described corpse or other object for laboratory examination and chemical testing to draw gravitation to utilize described water body.
3. the checking chip of autologous protection against the tide as claimed in claim 1, wherein, described water body receives sheet to have geometry three-dimensional shape, and the aqueous vapor in this checking chip surrounding air of Absorbable rod.
4. a checking chip for autologous protection against the tide, comprises:
One sheet flushes straw mats, has first end and the second end;
One sample pad, is formed on the first end that this flushes straw mats, and in order to accept the infiltration of a corpse or other object for laboratory examination and chemical testing;
One reactant release pad, is formed on this and flushes on straw mats and to touch this sample pad, and have the reactive material relative to this corpse or other object for laboratory examination and chemical testing;
One result display pad, is formed on this and flushes on straw mats and to touch this reactant release pad, and in order to the reaction result of this reactive material of presenting this corpse or other object for laboratory examination and chemical testing; And
One water body receives sheet, be formed on this second end flushing straw mats and touch this result display pad, and formed primarily of the drying agent material that tool water body receives, there is capillary effect, with the capillary flow attractive force utilizing water absorptivity to provide this corpse or other object for laboratory examination and chemical testing, at least absorb the aqueous vapor in this checking chip package body in surrounding air simultaneously.
5. the checking chip of autologous protection against the tide as claimed in claim 4, wherein, at least receives to set up between sheet and described sample pad at described water body and draws footpath of leading the way, receive the water absorptivity of sheet to provide the capillary flow attractive force of a described corpse or other object for laboratory examination and chemical testing to utilize described water body.
6. the checking chip of autologous protection against the tide as claimed in claim 4, wherein, corpse or other object for laboratory examination and chemical testing water body receives sheet to have geometry three-dimensional shape, and the aqueous vapor in this checking chip surrounding air of Absorbable rod.
7. the checking chip of the autologous protection against the tide as described in claim 1 or 4, wherein, corpse or other object for laboratory examination and chemical testing water body receives sheet to be sheet drying agent, overlay film drying agent or dry paper.
8. the checking chip of the autologous protection against the tide as described in claim 1 or 4, wherein, the external packing of checking chip can be clamping structure, itemize formula, pen type structure, chip semi-manufacture, volume structure formula semi-manufacture or capsule-type.
9. a manufacture method for the checking chip of autologous protection against the tide, comprises:
There is provided there is first end and the second end one flush straw mats material strip; And
Receiving sheet to be sequentially combined in this in sample bedding and padding band, a reactant release bedding and padding band, a result display bedding and padding band, a banded water body flushes on straw mats material strip, to form the banded checking chip do not cut;
Wherein, in this banded checking chip, this sample pad material strip is bonded to the first end that this flushes straw mats material strip, and the infiltration of a corpse or other object for laboratory examination and chemical testing can be accepted with this sample pad material strip, this reactant release bedding and padding are with touching this sample pad material strip, and this reactant release bedding and padding band has the reactive material relative to this corpse or other object for laboratory examination and chemical testing, this result display bedding and padding are with touching this reactant release pad, and this result display bedding and padding band can present the reaction result of this reactive material of this corpse or other object for laboratory examination and chemical testing, this banded water body receives sheet to touch this result display bedding and padding band, and this banded water body receives sheet to form primarily of drying agent material, with the capillary flow attractive force utilizing water absorptivity to provide this corpse or other object for laboratory examination and chemical testing, aqueous vapor in this checking chip surrounding air of simultaneously stability.
10. the manufacture method of the checking chip of autologous protection against the tide as claimed in claim 9, wherein, this manufacture method comprises further:
This banded checking chip do not cut, and form multiple shape checking chip.
CN201410003629.1A 2013-08-15 2014-01-02 Self-damp-proof test chip and manufacturing method thereof Pending CN104374902A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TW102129231A TW201506402A (en) 2013-08-15 2013-08-15 Autologous moisture-proof inspection chips and the manufacturing method thereof
TW102129231 2013-08-15

Publications (1)

Publication Number Publication Date
CN104374902A true CN104374902A (en) 2015-02-25

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JP (1) JP2015036686A (en)
CN (1) CN104374902A (en)
TW (1) TW201506402A (en)

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CN112029821A (en) * 2020-08-18 2020-12-04 美康生物科技股份有限公司 Blood fat test card and application thereof

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JPH0720125A (en) * 1993-06-30 1995-01-24 Toppan Printing Co Ltd Test piece provided with drying function and packaging method therefor
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CN112029821A (en) * 2020-08-18 2020-12-04 美康生物科技股份有限公司 Blood fat test card and application thereof

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TW201506402A (en) 2015-02-16
JP2015036686A (en) 2015-02-23

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Application publication date: 20150225