CN104363882A - In vitro method for the diagnosis and surveillance of cancer - Google Patents
In vitro method for the diagnosis and surveillance of cancer Download PDFInfo
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- CN104363882A CN104363882A CN201280074038.2A CN201280074038A CN104363882A CN 104363882 A CN104363882 A CN 104363882A CN 201280074038 A CN201280074038 A CN 201280074038A CN 104363882 A CN104363882 A CN 104363882A
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- cosmetic composition
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- hydrophobic silica
- silica aerogel
- wax
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/60—Particulates further characterized by their structure or composition
- A61K2800/61—Surface treated
- A61K2800/612—By organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/60—Particulates further characterized by their structure or composition
- A61K2800/61—Surface treated
- A61K2800/62—Coated
- A61K2800/622—Coated by organic compounds
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Abstract
Disclosed is a cosmetic composition for keratin materials, especially the skin and the lips, the hair and the nails. A cosmetic method for treating keratin materials using said composition is also disclosed. More specifically, the cosmetic composition comprises a mixture of at least one wax containing at least one fatty acid having 16 to 18 carbon atoms, or a mixture thereof, and hydrophobic silica aerogel particles having a specific surface area per unit of mass (SM) ranging from 500 to 1500 m2/g and a size expressed as the volume-average diameter (D[0.5]) ranging from 1 to 1500 mum.
Description
Apply some make up compositions to the present invention relates to a kind of keratin material (especially skin and lip, hair and fingernail).The invention still further relates to the cosmetic method using said composition processing angle protein material.
In skin care cosmetic composition field, known practice be use organic wax to absorb sebum and perspiration to skin control oil and/or optionally smooth crude and hide skin blemishes.
But, generally can with dry coarse sensation and sticky feeling when using these waxes, consumer is difficult to accept.And wax can cause said composition unstable because As time goes on its crystalline size grows when high concentration.
Fatty acid is also widely used as control oil preparation because it can produce soft sensation on skin, but fatty acid must use to obtain the oily effect of described control with high level, this selection to quality, the stability of said composition, and particularly the cost of this formula causes restriction.
But still need a kind of cosmetic composition, it has control oily effect and/or can hide skin blemishes, has good cosmetic properties, especially the soft feel when using, through time stable, and lessly to limit by cost.
The applicant finds, is selected from and has the fatty acid of C16 to C18 carbon atom or the wax of its mixture and hydrophobic silica aerogel granule, just can meet this requirement by combination in the composition.
More specifically, an object of the present invention is cosmetic composition, it comprises the mixture of following component:
-at least one wax, it contains fatty acid or its mixture that at least one has 16 to 18 carbon atoms; With
-hydrophobic silica aerogel granule, its unit mass specific surface area (S
m) be 500 to 1500m
2/ g, and represent with volume mean diameter (D [0.5]) and be of a size of 1 to 1500 μm.
This mixture can obtain this compositions, and it feels comfortable and soft when using, and has control oil and soft focus effect.This mixture also meets the requirement of ageing stability.
Another object of the present invention is cosmetic composition, and it comprises the mixture of following component:
-at least one wax, it contains fatty acid or its mixture that at least one has 16 to 18 carbon atoms;
-hydrophobic silica aerogel granule, its unit mass specific surface area (S
m) be 500 to 1500m
2/ g, and represent with volume mean diameter (D [0.5]) and be of a size of 1 to 1500 μm; With
-at least one Chinese white.
This mixture can obtain this compositions, and it has control oil and soft focus effect, has whitening effect, and show naked adornment outward appearance simultaneously owing to reducing the obvious degree of flaw on skin.
Cosmetic composition of the present invention can be the cosmetic composition of any type, such as foundation cream, face powder, eye shadow, screening free time product, rouge, lipstick, lip pomade, lip gloss, liner, eyebrow pencil, eyeliner, mascara, health color make-up product, skin coloring products, care product such as nurse frost, toning frost or sunscreen product, and preferred care product such as nurses frost.
The form of mixture of the present invention advantageously gel or frost.
Another object of the present invention is for making up and/or nurse the cosmetic method of keratin material, comprising the step compositions defined as previously mentioned being applied to described material.
Hereinafter, term " at least one " is equivalent to " one or more ", and unless otherwise clearly, the endpoint value of numerical range is included within the scope of this.
wax
It is solid-state lipophilic cpd that wax paid close attention in the context of the present invention is generally under room temperature (25 DEG C), and the conversion of its solid-liquid states of matter is reversible, and has the fusing point being more than or equal to 30 DEG C, and this fusing point can reach 200 DEG C and especially reach 120 DEG C (see such as
ullmann's Encyclopedia of Industrial Chemistry" Waxes " Uwe Wolfmeier et al.; Http:// onlinelibrary.wiley.com/doi/10.1002/14356007.a28_103/pdf; Online open: on June 15th, 2000, DOI:10.1002/14356007.a28_103; 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim; DOI:10.1002/14356007.a28_103).
Especially, be suitable for wax of the present invention and can have the fusing point that is greater than 40 DEG C and not decompose, be particularly more than or equal to 45 DEG C, be especially more than or equal to the fusing point of 55 DEG C.
According to an embodiment of the invention, wax is must not exceed 10000mPa.s higher than melt viscosity during dropping point 10 DEG C.
What available wax was in the compositions of the present invention selected from animal origin, plant origin, mineral origin or synthesized source is at room temperature solid-state wax, and composition thereof.The latter can be native paraffin, partial synthesis wax or complete synthesis wax (see
ullmann's Encyclopedia of Industrial Chemistry" Waxes ", source is the same).
Therefore, by the fluid properties of wax under high temperature, be easier to mixing, operation at such temperatures and regulate the present composition.
As the example being suitable for wax of the present invention, can especially mention alkyl wax, such as, Cera Flava, lanolin wax, Chinese insect wax, rice bran wax, Brazil wax, candelilla wax, ouricury wax, esparto wax, berry wax, shellac wax, Japan wax and sumac wax; Montan wax, orange wax, Fructus Citri Limoniae wax, microwax, paraffin and ceresine; Tissuemat E, the wax obtained by Fisher-Tropsch synthesis, and wax copolymer, also have its ester.
Can also mention by containing straight chain or the C of side chain
8-C
32aliphatic chain (preferred C
16to C
18chain) animal oil or vegetable oil catalytic hydrogenation obtain fatty acid.Wherein, stearic acid, Palmic acid or its mixture can especially be mentioned.Fatty acid used in the present invention can by commercially available acquisition, such as with title AEC Stearic Acid purchased from A & E Connock (Perfumery & Cosmetics) company limited, with title Emersol purchased from Emery Oleochemical company, with title Palmitic Acid PC purchased from Protameen Chemicals company.
Also can mention silicone wax (C
30-45alkyl dimethicone) and fluoro wax.
Can also use with the wax of the title of Phytowax ricin 16L64 and 22L73 by Sophim Company, this wax is by obtaining carrying out hydrogenation with the Oleum Ricini of spermol esterification.This kind of wax can see patent application FR-A-2 792 190.
Spendable wax is the alkene wax C being used alone or using as mixture
20-C
40alkyl (hydroxy stearate acyl-oxygen base) stearate (alkyl comprises 20-40 carbon atom).
Such wax especially for be called Kester Wax K82 P by Koster Keunen Company name, the product of Hydroxypolyester K 82P and Kester Wax K 80P.
Preferably, compositions of the present invention comprises at least one wax, and it is selected from the fatty acid or its mixture with 16 to 18 carbon atoms.
Desirably, it is 6% to 18% weight that compositions of the present invention comprises relative to said composition gross weight, the preferably wax of 7% to 10% weight.
hydrophobic silica aerogel
Aerosil is porous material, and it is obtained by the liquid component substituting (by drying) silica gel with air.
It is usually via the sol-gel process synthesis in liquid medium, then dry, generally passes through supercritical fluid extraction; The most frequently used one is supercritical CO
2.This kind of drying makes the contraction avoiding hole and material become possibility.Sol-gel process and various drying means are described in detail in Brinker CJ. and Scherer G.W., Sol-Gel Science:New York:Academic Press, in 1990.
Unit mass specific surface area (the S of the hydrophobic silica aerogel granule used in the present invention
m) be 500 to 1500m
2/ g, preferably 600 to 1200 m
2/ g and preferred 600 to 800 m further
2/ g, and represent with volume mean diameter (D [0.5]) and be of a size of 1 to 30 μm, preferably 5 to 25 μm, preferably 5 to 20 μm further, and further preferably 5 to 15 μm.
This unit mass specific surface area can via BET(Brunauer-Emmett-Teller) N2 adsorption method measures, it is described in Journal of the Amercian Chemical Society, 60 volumes, 309 pages, in 1938 2 months, and corresponding to international standard ISO 5794/1(Appendix D).This BET specific surface area is corresponding to total specific surface area of paid close attention to granule.
The size of silica aerogel particles uses commercial particle size analyzer to measure by static light scattering, such as, from MasterSizer 2000 type of Malvern.Data are at the enterprising row relax in Mie scattering theory basis.This theory is accurate for isotropic granule, with regard to aspherical particle, makes the mensuration of " effectively " particle diameter become possibility.This theory is especially described in Van de Hulst, and the open source literature " Light Scattering by Small Particles " of H.C., the 9th and 10 chapters, Wiley, New York, in 1957.
According to a favourable embodiment, the unit mass specific surface area (S of the hydrophobic silica aerogel granule used in the present invention
m) be 600 to 800m
2/ g and represent with volume mean diameter (D [0.5]) and be of a size of 5 to 20 μm, and preferably 5 to 15 μm further.
The silica aerogel particles used in the present invention advantageously can have 0.04g/cm
3to 0.10g/cm
3and preferred 0.05g/cm
3to 0.08g/cm
3tap density (r).
In the context of the present invention, this density (being called as tap density) can be assessed according to scheme below:
The powder of 40g is poured in graduated cylinder; Then graduated cylinder is placed on Stav 2003 machine from Stampf Volumeter; Then graduated cylinder is made to stand a series of 2500 compaction actions (repeating this operation until the volume differences between double test is less than 2%); Then the direct final volume Vf measuring compacted powder on graduated cylinder.Measuring tap density by ratio m/Vf, is here that 40/Vf(Vf is with cm
3expression and m represent with g).
According to an embodiment, the unit volume specific surface area S of the hydrophobic silica aerogel granule used in the present invention
vbe 5 to 60m
2/ cm
3, preferably 10 to 50m
2/ cm
3and preferred 15 to 40m further
2/ cm
3.
Relational expression: S
v=S
m× r provides unit volume specific surface area, and wherein r is with g/cm
3the tap density represented, and S
mfor unit mass specific surface area defined above, with m
2/ g represents.
Preferably, the absorbency capacity that hydrophobic silica aerogel granule according to the present invention is measured at wetting point place is 5 to 18ml/g, preferably 6 to 15ml/g and preferred 8 to 12ml/g further.
(W is expressed as at wetting point
p) absorbency capacity that records of place is corresponding to joining in 100g granule to obtain the water yield needed for homogeneous paste thing.
It is measured according to the method for the oil absorption of the measurement powder described in wetting point method or standard NF T 30-022.Its oil mass absorbed by powder corresponding to the oil mass of adsorbing on the active surface of powder and/or when measuring wetting point, it is described below:
The powder measured by 2g is placed on a glass, then drips oil (the different nonyl ester of different n-nonanoic acid).After adding 4 to 5 oil drippings to powder, use toolsetting to mix, and continue to add oil until form the agglomerate of oil and powder.Now, once add an oil dripping and then grind this mixture with toolsetting.When obtaining solid smooth pastel, stop adding of oil.This pastel must can be sprawled and ftracture on a glass and not or in bulk.Then the oil volume V of use is recorded
s(representing with ml).Oil absorption is corresponding to ratio V
s/ m.
The aeroge that the present invention uses is hydrophobic silica aerogel, (the INCI title: silylanizing Silicon stone) of preferred silica silylate.
Term " hydrophobic silica " refer to surface through silylating agent process thus make OH group by silyl-group Si-Rn(as trimethyl silyl group) functionalized any silicon dioxide, described silylating agent such as halogenated silanes as alkylchlorosilane, siloxanes particularly dimethyl siloxane as hexamethyl disiloxane, or silazane.
About the preparation by the hydrophobic silica aerogel granule of silylanizing surface modification, can list of references US 7 470 725.
The hydrophobic silica aerogel granule of trimethyl silyl group surface modification can be used especially.
As the example of the hydrophobic silica aerogel that can use in the present invention, that can mention comprises the aeroge sold with title VM-2260 (INCI name: silylanizing Silicon stone) by Dow Corning company, and its granule has average-size and 600 to the 800m of about 1000 microns
2the unit mass specific surface area of/g.
The aeroge also can mentioned is sold with numbering AEROGEL TLD 201, AEROGEL OGD 201, AEROGEL TLD 203, ENOVA AEROGEL MT 1100 and ENOVA AEROGEL MT 1200 by Cabot company.
Particularly operable aeroge is for what sold with title VM-2270 (INCI name: silylanizing Silicon stone) by Dow Corning company, and its granule has average-size and 600 to the 800m of 5-15 micron
2the unit mass specific surface area of/g.
With the gauge of active substance, the preferred gross weight relative to said composition is with 0.1% to 1% weight in described cosmetic composition for silica aerogel particles of the present invention, and more preferably the amount of 0.4% to 0.6% weight exists.
" white " pigment
The specific pigment used in compositions of the present invention refers to the inorganic of water insoluble solution or organic granular, described granule is white, spherical or aspherical and porous or atresia, and has the refractive index being more than or equal to 1.6, being more than or equal to 1.8 especially, being preferably 1.6 to 2.5.
" pigment " of the present invention has and is preferably less than 15 microns, is less than the volume size of 10 microns especially.Especially, " pigment " of the present invention has and is preferably less than 15 microns and be particularly less than the volume size of 10 microns more than 200 nanometers, preferably greater than 500 nanometers.
Especially, described pigment is white powder.
Term " white " is intended to refer to white and induced color (canescence, snowy white, silvery white etc.) thereof especially or have silver color, white color, instead of primary colours and induced color.
Especially, should " white " pigment have at TSL(hue, saturation, intensity) in system close to the brightness value L of 100.
In CIE Lab 1976 chrominance space, the colour measurement of L* and C* can use MINOLTA CR400
?colourity color difference meter carries out.
For this reason, disperse (with three-roller (tricylinder) grinding) in advance in transparence cosmetic medium with the percentage ratio (pigment of such as 5-6%) can giving opacity this pigment, and join 15 milliliters of tanks (opening diameter: 1.9 centimetres subsequently; The degree of depth: 1.8 centimetres) in.By flattening the surperficial decurl of the cosmetic vehicles introduced with microscope slide.Place cuvette and this surface contact subsequently and measure colorimetric parameter.
This MINOLTA CR400
?the colourity color difference meter reference white (for the whiteware corrected, as Spectralon) and trap light with the lightness L* value of 100 and the saturation C* value of 0 corrects.
According to a particular implementation, " white " of the present invention pigment to exceed having especially according to aforementioned schemes or equal 95 lightness L* value and less than or equal to 3 saturation C* value.
Thus, compositions of the present invention comprises and has the refractive index being more than or equal to 1.6 and the volume size being preferably less than 15 microns, is particularly less than at least one pigment of the porous of the volume size of 15 microns or atresia, spherical or aspherical, inorganic or organic white particle form more than 200 nanometers, preferably greater than 500 nanometers.
Described pigment is (i) selected from bismuth oxychloride, the insoluble barium salt particularly barium sulfate of titanium oxide, zinc oxide, optional dispersion especially, calcium carbonate, calcium sulfate, Gypsum Fibrosum preparata, the natural powder in mineral, animal or plant source, whiting, Gypsum Fibrosum powder, alabaster powder or selenite powder, eggshell or shellfish powder, vegetable ivory and composition thereof.
Bismuth oxychloride can former state (in powder form) use, or advantageously uses with the dispersion in ester oil, and described ester oil is selected from Dermol 105 especially; Sad different cetyl; Isononyl isononanoate, IPIS, hydroxy stearic acid 2-Octyl Nitrite, stearic acid 2-octyldodecyl, the different stearyl ester of isostearic acid; And composition thereof.Preferably, this bismuth oxychloride dispersion comprises hydroxy stearic acid 2-Octyl Nitrite, as by MERCK company with Biron
?liquid Silver runs after fame product sold.
According to a kind of replacement scheme, white tone coated interference pigment can also be used as Chinese white (i), described white tone coated interference pigment is as scribbled the fluorophologopite base composite particles of titanium dioxide and stannum oxide, such as by ECKART company with SYNCRYSTAL SILVER run after fame sell those, it is different from the coated interference pigment of non-white tone, such as particularly Timiron Silk Blue Muscovitum/titanium dioxide/stannum oxide blue cast pearling agent.
According to a kind of particular implementation, described pigment is (i) white tone coated interference pigment.
According to another particular implementation, described pigment is (i) selected from bismuth oxychloride, the insoluble barium salt particularly barium sulfate of titanium oxide, zinc oxide, optional dispersion, calcium carbonate, calcium sulfate, Gypsum Fibrosum preparata, the natural powder in mineral, animal or plant source, whiting, Gypsum Fibrosum powder, alabaster powder or selenite powder, eggshell or shellfish powder, vegetable ivory and composition thereof, preferred titanium oxide, zinc oxide and composition thereof, and be not coated interference pigment.
According to a particular implementation, said composition comprise at least titanium oxide as pigment (i), and optionally in conjunction with white tone coated interference pigment.
Is the titanium oxide be encapsulated in silica dioxide granule not included in pigment of the present invention definition (i); as comprised the granule of the porous silica of titanium dioxide, particularly to be run after fame the granule or the PC-LS-14 that sold by MIYOSHI KASEI sold with God Ball PC-LS by Suzuki Oil and Fat company.
Preferably, this pigment is (i) selected from the titanium oxide of coating or uncoated rutile or Detitanium-ore-type.
Thus, according to a kind of particular implementation, compositions of the present invention at least comprises the titanium oxide of coating or uncoated rutile or Detitanium-ore-type.
Pigment used according to the invention can yes or no at least one hydrophilic or hydrophobicity inorganic agent surface-treated wholly or in part.
For object of the present invention, the surface treatment of pigment of the present invention typically refers to the surface treatment wholly or in part adopting surface conditioning agent, absorption and sorption or be grafted on described pigment.
This surface-treated pigment can be prepared according to the surface-treated technology for chemistry, electronics, mechanochemistry or engineering properties well known in the art.Also commercially available prod can be used.
This surface conditioning agent can be evaporated by solvent, chemical reaction or covalent bond generate and absorption and sorption or be grafted on this pigment.
This surface treatment can account for 0.1 to 50 % by weight of this coating pigment gross weight and be in particular 0.5 to 5 % by weight.
This surface treatment such as can in other composition described pigment being mixed described cosmetic or care composition before pass through, optional under heat condition, under agitation make pigment simply mix with liquid surface inorganic agent and the mode that makes this surface conditioning agent be adsorbed on solid particles surface is carried out.
This surface treatment such as can be undertaken by the mode making the chemical reaction of surface conditioning agent and this surface of pigments and generate covalent bond between surface conditioning agent and granule.The method is described in patent US 4 578 266 especially.
This chemical surface treatment can comprise and is diluted in volatile solvent by this surface conditioning agent, by pigment dispersion in the mixture, and this volatile solvent of slow evaporation subsequently, make surface conditioning agent be deposited on the surface of pigment.This volatile solvent can be water.
lipotropy or hydrophobicity inorganic agent
According to a kind of particular implementation of the present invention, pigment of the present invention can use at least one hydrophobicity or the surface treatment of lipotropy inorganic agent, and described inorganic agent is selected from siloxane surface inorganic agent; Fluorochemical surface treatment; Fluorosilicone surface conditioning agent; Metal soap, N-acylated amino or its salt; Lecithin and derivant thereof; Isopropyl three iso stearyl titanate esters; The different stearyl ester of decanedioic acid; Plant or natural animal wax, polarity synthetic wax; Fatty ester; Fatty alcohol; Phospholipid and composition thereof.
According to a kind of particular implementation, the fluorochemical surface treatment surface treatment of this pigment, especially fluorinated alcohols surface conditioning agent or fluoro-alkyl surface conditioning agent.
According to one preferred embodiment, the operable pigment of the present invention is by fluorinated alcohols phosphate ester surface-treated titanium dioxide.This pigment ratio as with title Tudor Aspen by Kingfisher Colours companies market or with title AC series by Active Concepts companies market.
hydrophilic inorganic agent
According to a kind of particular implementation, this pigment can use the surface treatment of at least one hydrophilic inorganic agent, and described inorganic agent is selected from biopolymer, carbohydrate, polysaccharide, polyacrylate or polyethyleneglycol derivative.Mineral agent can also be mentioned, as silicon dioxide, silicate, aluminium oxide and composition thereof (such as: silica/alumina).
As the present invention for being coated with the example of the biopolymer treating solubilising material, the polymer of the monomer based on carbohydrate type can be mentioned, particularly derived from algae, terrestrial plant, fungus or biotechnology, plankton or arthropod shell those.Particularly can mention guar gum, locust bean gum, xanthan gum, Radix Acaciae senegalis, sclerotium gum; Rhizoma amorphophalli, carrageenin, alginate and derivant thereof, pectin, agar; Glycogen; Glucosan; Starch and derivant thereof; Cellulose and its derivates; Hyaluronate, as hyaluronate sodium and derivant thereof; Soluble protein polysaccharide; Glycosaminoglycans, chitin, Chitosan-phospholipid complex, and composition thereof.
C
1-C
20diol alkylene or C
1-C
20diol alkylene ether, separately or with three C
1-C
20alkyl silane is combined, and also can be used as surface conditioning agent.The pigment with the process of PEG alkyl ether alkoxysilane surface can be mentioned as an example, the pigment with the process of PEG-8-methyl ether triethoxysilane of sale of such as being run after fame with " SW " pigment by KOBO company.
According to one preferred embodiment, compositions of the present invention at least comprises titanium oxide, particularly uses alumina/silica/trimethylolpropane surface-treated TiO
2, it to be run after fame with Tipaque PF671 by Ishihara Sangyo and to be run after fame sale with SA-TAO by Myoshi Kasei.
According to another preferred implementation, compositions of the present invention comprises at least one and is optionally dispersed in bismuth oxychloride in hydroxy stearic acid 2-Octyl Nitrite, as by MERCK company with Biron
?liquid Silver runs after fame product sold.
According to another embodiment, compositions of the present invention at least comprises the fluorophologopite base composite particles scribbling titanium dioxide and stannum oxide, as by ECKART company with SYNCRYSTAL SILVER run after fame sell those.
Described pigment (i) usual be 0.1% to 4 % by weight, preferably 0.5 to 3 % by weight relative to described composition total weight (for the dispersion of this pigment in the carrier or applied when, refer to active substance) content be present in compositions of the present invention.
When white tone coated interference pigment (i), scribble the situation of the fluorophologopite base composite particles of titanium dioxide and stannum oxide as above-mentioned, they by preferred with relative to described composition total weight be less than or equal to 2 % by weight, be especially less than or equal to 1 % by weight, the amount of 0.5 % by weight that is particularly less than or equal to is present in said composition.
auxiliary agent
Compositions of the present invention can also comprise auxiliary agent conventional in cosmetics and/or dermatological by known way, the fatty acid ester of such as activating agent, antiseptic, antioxidant, chelating agent, pH adjusting agent (acid or alkalescence), spice, filler, antibacterial, odour absorbents, coloring agent (pigment and dyestuff), film forming polymer, emulsifying agent such as Polyethylene Glycol, the fatty acid ester of glycerol and the fatty acid ester of sorbitan, it is optionally polyoxyethylated, polyoxyethylated fatty alcohol and fatty acid ester or sugar (as sucrose or glucose) ether; Thickening agent and/or gellant, particularly polyacrylamide, acrylic acid series homopolymer and copolymer, and the homopolymer of acrylamido methyl propane sulfonic acid and copolymer, and lipid vesicle.The amount of these various auxiliary agents is those conventional amount used considering in this area to use, such as, be 0.5% to 3% of composition total weight.Depend on its character, these auxiliary agents can be introduced in fatty phase, aqueous phase and/or lipid vesicle.
Much less, those skilled in the art can the optional added compound of careful selection this or these, and/or its consumption, with the adverse effect making the control oil/soft focus character of the present composition can not or substantially can not add by this expection.
In the present patent application, unless mentioned especially in addition, content represents with weight basis relative to the gross weight of compositions.
The following examples are used for illustrating the compositions and methods of the invention, but limit scope of the present invention never in any form.Unless otherwise indicated, all numbers in an embodiment and percentage ratio are all benchmark with weight, and all measured values are all about 25 DEG C of acquisitions.
Embodiment
Embodiment 1: formula 1 of the present invention
Program:
-heating phase A to 80-85 DEG C,
-add phase B to phase A, keep this temperature 15 minutes,
-be cooled to 70-75 DEG C, add phase C,
-be cooled to 30-35 DEG C, add phase D and E.
Embodiment 2: formula 2 of the present invention
Program:
-heating phase A to 80-85 DEG C,
-add phase B to phase A, keep this temperature 15 minutes,
-be cooled to 70-75 DEG C, add phase C,
-be cooled to 30-35 DEG C, add phase D and E.
Embodiment 3: comparative formula 1
Program:
-heating phase A to 80-85 DEG C,
-add phase B to phase A, keep this temperature 15 minutes,
-be cooled to 70-75 DEG C, add phase C,
-be cooled to 30-35 DEG C, add phase D.
Embodiment 4: comparative formula 2
Program:
-heating phase A to 80-85 DEG C,
-add phase B to phase A, keep this temperature 15 minutes,
-be cooled to 70-75 DEG C, add phase C,
-be cooled to 30-35 DEG C, add phase D.
Embodiment 5: comparative formula 3
Program:
-heating phase A to 70-75 DEG C, adds phase B,
-be cooled to 30-35 DEG C, add phase C and D.
Embodiment 6: comparative formula 4
Program:
-heating phase A to 70-75 DEG C, adds phase B,
-be cooled to 30-35 DEG C.
Embodiment 7: contrast test
By by embodiment 1 to 6 application to skin, 6 people groups are utilized to carry out the oil resistant light effect of testing example 1 to 6.
Oil resistant light effect is marked according to 0 to 5.Mark higher, the oil resistant light effect of this embodiment is better.
By by embodiment 1 to 6 application to skin, 6 people groups are utilized to carry out the Fugitive Beauty white effect of testing example 1 to 6.
Fugitive Beauty white effect is marked according to 0 to 5.Mark higher, the Fugitive Beauty white effect of this embodiment is better.
As the table shows, compared with the comparative example formula of embodiment 3 to 6, compositions of the present invention demonstrates obviously better oil resistant light effect, and better Fugitive Beauty white effect.
Embodiment 8: oily skin whitening gel frost
Program:
-heating phase A to 80-85 DEG C,
-add phase B to phase A, keep this temperature 15 minutes,
-be cooled to 70-75 DEG C, add phase C1,
-be cooled to 30-35 DEG C, add phase D, C2, E, F.
Embodiment 9: oily skin skin whitener
Program:
-heating phase A to 80-85 DEG C,
-add phase B to phase A, keep this temperature 15 minutes,
-be cooled to 30-35 DEG C, add phase C and D.
Claims (17)
1. a cosmetic composition, it comprises:
-at least one wax, it contains the fatty acid that at least one has 16 to 18 carbon atoms, or its mixture; With
-at least one hydrophobic silica aerogel granule, its unit mass specific surface area (S
m) be 500 to 1500m
2/ g, and represent with volume mean diameter (D [0.5]) and be of a size of 1 to 1500 μm.
2. cosmetic composition according to claim 1, wherein said wax contains at least one Palmic acid, at least one stearic acid or its mixture.
3. according to the cosmetic composition of aforementioned any one claim, wherein said compositions comprises 6-18% weight, and the described wax of preferred 7-10% weight, relative to the gross weight of described compositions.
4., according to the cosmetic composition of aforementioned any one claim, the unit mass specific surface area of wherein said hydrophobic silica aerogel granule is 600 to 1200m
2/ g, and more preferably 600 to 800m
2/ g.
5. according to the cosmetic composition of aforementioned any one claim, representing with volume mean diameter of wherein said hydrophobic silica aerogel granule is of a size of 1 to 1000 μm, preferably 1 to 100 μm, particularly 1 to 30 μm, more preferably 5 to 25 μm, preferably 5 to 20 μm and further preferably 5 to 15 μm further.
6. according to the cosmetic composition of aforementioned any one claim, the unit mass specific surface area (S of wherein said hydrophobic silica aerogel granule
m) be 600 to 800m
2/ g, and represent with volume mean diameter (D [0.5]) and be of a size of 5 to 20 μm and more preferably 5 to 15 μm.
7., according to the cosmetic composition of aforementioned any one claim, the tap density of wherein said hydrophobic silica aerogel granule is 0.04g/cm
3to 0.10g/cm
3and preferred 0.05g/cm
3to 0.08g/cm
3.
8. according to the cosmetic composition of aforementioned any one claim, the unit volume specific surface area S of wherein said hydrophobic silica aerogel granule
vbe 5 to 60m
2/ cm
3, preferably 10 to 50m
2/ cm
3and preferred 15 to 40m further
2/ cm
3.
9. according to the cosmetic composition of aforementioned any one claim, the absorbency capacity that wherein said hydrophobic silica aerogel granule is measured at wetting point place is 5 to 18ml/g, preferably 6 to 15ml/g and preferred 8 to 12ml/g granule further.
10., according to the cosmetic composition of aforementioned any one claim, wherein said hydrophobic silica aerogel granule is by trimethyl silyl group surface modification.
11. according to the cosmetic composition of aforementioned any one claim, and wherein said compositions comprises 0.1% to 1% weight, preferably the described hydrophobic silica aerogel granule of 0.4% to 0.6% weight, relative to the gross weight of described compositions.
12. according to the cosmetic composition of aforementioned any one claim, comprises the hydrophobic silica aerogel granule by trimethyl silyl group surface modification; With Palmic acid, stearic acid or its mixture.
13. according to the cosmetic composition of aforementioned any one claim, and it comprises:
-at least one wax, it contains fatty acid or its mixture that at least one has 16 to 18 carbon atoms;
-at least one hydrophobic silica aerogel granule, its unit mass specific surface area (S
m) be 500 to 1500m
2/ g, and represent with volume mean diameter (D [0.5]) and be of a size of 1 to 1500 μm; With
-at least one Chinese white.
14. cosmetic composition according to claim 13, wherein said Chinese white is selected from spherical or aspherical, porous or atresia pigment, and it is by least one hydrophilic or the surface treatment wholly or in part of hydrophobicity inorganic agent.
15. according to the cosmetic composition of claim 13 or 14, and it is for being fluorinated surface conditioning agent all or part of surface-treated Chinese white TiO
2.
16. according to the cosmetic composition of aforementioned any one claim, wherein said composition comprises at least one auxiliary agent further, and it is selected from activating agent, antiseptic, antioxidant, chelating agent, pH adjusting agent (acid or alkalescence), spice, filler, antibacterial, odour absorbents, coloring agent (pigment and dyestuff), the fatty acid ester of film forming polymer, emulsifying agent, glycerol and the fatty acid ester of sorbitan; Thickening agent, gellant and lipid vesicle.
17. for making up and/or nursing the cosmetic method of keratin material, comprise the step by being applied to described material according to the cosmetic composition of aforementioned any one claim.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910155368.8A CN109998934A (en) | 2012-06-21 | 2012-06-21 | Cosmetic composition and its application method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2012/077307 WO2013189060A1 (en) | 2012-06-21 | 2012-06-21 | Cosmetic composition and method for using thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910155368.8A Division CN109998934A (en) | 2012-06-21 | 2012-06-21 | Cosmetic composition and its application method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104363882A true CN104363882A (en) | 2015-02-18 |
Family
ID=49768041
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910155368.8A Pending CN109998934A (en) | 2012-06-21 | 2012-06-21 | Cosmetic composition and its application method |
| CN201280074038.2A Pending CN104363882A (en) | 2012-06-21 | 2012-06-21 | In vitro method for the diagnosis and surveillance of cancer |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910155368.8A Pending CN109998934A (en) | 2012-06-21 | 2012-06-21 | Cosmetic composition and its application method |
Country Status (4)
| Country | Link |
|---|---|
| CN (2) | CN109998934A (en) |
| BR (1) | BR112014031423A2 (en) |
| WO (1) | WO2013189060A1 (en) |
| ZA (1) | ZA201409029B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115475133A (en) * | 2016-11-22 | 2022-12-16 | 伊比西(北京)植物药物技术有限公司 | Ivory fruit powder and mannan from ivory fruit |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023549714A (en) * | 2020-10-30 | 2023-11-29 | ロレアル | Composition for conditioning keratin substances |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101530375A (en) * | 2008-03-11 | 2009-09-16 | 莱雅公司 | Cosmetic composition comprising an ascorbic acid or salicylic acid compound |
| CN103347483A (en) * | 2010-12-21 | 2013-10-09 | 莱雅公司 | Cosmetic composition comprising silica aerogels particles and hydrocarbon-based oils |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009120602A1 (en) * | 2008-03-25 | 2009-10-01 | Mary Kay Inc. | Sebum absorption compositions |
-
2012
- 2012-06-21 CN CN201910155368.8A patent/CN109998934A/en active Pending
- 2012-06-21 BR BR112014031423A patent/BR112014031423A2/en not_active Application Discontinuation
- 2012-06-21 WO PCT/CN2012/077307 patent/WO2013189060A1/en active Application Filing
- 2012-06-21 CN CN201280074038.2A patent/CN104363882A/en active Pending
-
2014
- 2014-12-09 ZA ZA2014/09029A patent/ZA201409029B/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101530375A (en) * | 2008-03-11 | 2009-09-16 | 莱雅公司 | Cosmetic composition comprising an ascorbic acid or salicylic acid compound |
| CN103347483A (en) * | 2010-12-21 | 2013-10-09 | 莱雅公司 | Cosmetic composition comprising silica aerogels particles and hydrocarbon-based oils |
Non-Patent Citations (1)
| Title |
|---|
| TODD OSTERGAARD ET.AL.: "《Silica silylate aerogel for cosmetic applications》", 《IP.COM JOURNAL》, 30 January 2006 (2006-01-30) * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115475133A (en) * | 2016-11-22 | 2022-12-16 | 伊比西(北京)植物药物技术有限公司 | Ivory fruit powder and mannan from ivory fruit |
Also Published As
| Publication number | Publication date |
|---|---|
| BR112014031423A2 (en) | 2017-06-27 |
| CN109998934A (en) | 2019-07-12 |
| WO2013189060A8 (en) | 2015-01-29 |
| ZA201409029B (en) | 2015-10-28 |
| WO2013189060A1 (en) | 2013-12-27 |
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Application publication date: 20150218 |