CN104352655A - Poria cocos tea particle and preparation method thereof - Google Patents

Poria cocos tea particle and preparation method thereof Download PDF

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Publication number
CN104352655A
CN104352655A CN201410556028.3A CN201410556028A CN104352655A CN 104352655 A CN104352655 A CN 104352655A CN 201410556028 A CN201410556028 A CN 201410556028A CN 104352655 A CN104352655 A CN 104352655A
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poria
preparation
obtains
radix glycyrrhizae
aqueous extract
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肖玉林
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LUOTIAN COUNTY DABIESHAN LONGJIN TEA INDUSTRY SPECIALIZED COOPERATIVES
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LUOTIAN COUNTY DABIESHAN LONGJIN TEA INDUSTRY SPECIALIZED COOPERATIVES
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Priority to CN201410556028.3A priority Critical patent/CN104352655A/en
Publication of CN104352655A publication Critical patent/CN104352655A/en
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23FCOFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
    • A23F3/00Tea; Tea substitutes; Preparations thereof
    • A23F3/06Treating tea before extraction; Preparations produced thereby
    • A23F3/14Tea preparations, e.g. using additives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/076Poria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/34Campanulaceae (Bellflower family)
    • A61K36/344Codonopsis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/82Theaceae (Tea family), e.g. camellia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention discloses a poria cocos tea particle and a preparation method thereof, and belongs to the technical field of application of traditional Chinese medicines. The poria cocos tea comprises the following materials in parts by weight: 80-100 parts of poria cocos, 10-20 parts of tea leaves, 5-6 parts of codonopsis pilosula, 4-5 parts of white atractylodes rhizome, 3.5-5 parts of honey-fried licorice root, 3-4 parts of pericarpium citri reticulatae, and auxiliary materials which are 10-15% of the total mass. The preparation method comprises soaking, thermally extracting together with a honey-fried licorice root extracting solution, hydrolysing, precipitating with alcohol, mixing, homogenizing and pelletizing, wherein after the poria cocos material is boiled together with the honey-fried licorice root together, decomposed and precipitated with alcohol, the conversion rate of the poria cocos ingredient is increased by 20-60% in comparison with an existing processing method, the dissolution rate of ingredients like pachymaran is increased by 30-60%, and the tea particles are easy to absorb in a human body. The poria cocos tea particle has the effects of tonifying middle-Jiao and Qi, refreshing, developing the brain, promoting the intellect, clearing away the heart fire, improving eyesight, tonifying spleen, appetizing and the like.

Description

A kind of tuckahoe teat granule and preparation method thereof
Technical field
The present invention relates to Chinese medicine applied technical field, be specifically related to a kind of tuckahoe teat granule and preparation method thereof.
Background technology
Poria (formal name used at school: Poria cocos (Schw.) Wolf.) has another name called: Fu Tu, Poria, and Fu Ling, Fu Ling, volt Tu, pine fat, deep red morning lies prostrate tire, Poria, Fu rabbit, loose potato, Masson Pine potato, Song Ling.Medicinal part is the sclerotium of On Polyporaceae Poria.There is promoting diuresis to eliminate damp pathogen, spleen invigorating, the effect of calming the nerves.Can also be made into powdery be used for Ms hobby cleawhite pack.Distributed areas: Jilin, Anhui, Zhejiang, Fujian, Henan, Hubei, Guangxi, Sichuan, Guizhou, Yunnan.Ancients claim Poria to be " when four god medicine ", because its effect widely, regardless of the four seasons, by it and various compatibility of drugs, no matter cold, temperature, wind, wet all diseases, can play its unique effects.Poria sweet in the mouth, light, property are put down, and are used as medicine and have the function of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.But deficiency and coldness essence is sliding or collapse of QI person avoids clothes.
For good medical treatment and the health value of Poria, since ancient times, our ancestors have carried out many Application and Development to it, as pharmaceutical applications, its many and other drug compatibility, numerous medicine, food research institute develop it, and the product being used as medicine in the market has Ramulus Cinnamomi Poria pill, Poria Rhizoma Polygonati Odorati sheet, Poria yam slice etc., has cake, tuckahoe cream, Formica fusca tuckahoe wine etc. as health food.
Poria commonly uses decocting method as the usage that the prepared slices of Chinese crude drugs are traditional, and the methods such as the useful diluted alkaline lixiviate of modern crafts, water extract-alcohol precipitation, microwave radiation exaraction are extracted.Because principle active component in Poria is pachyman, its content accounts for more than 70% in Poria dry powder, and water solublity is very poor, adopts above technique to extract, and the pachyman proposition amount in raw material is less, and raw material availability is low, is a kind of larger waste to medical material.And beat powder and enter that ball is loose to be used, because Poria powder viscosity is poor, the medicine that in pill requirement formula, toughness is stronger, or add binding agent and can make ball, enter powder because of its dissolubility very poor, be not suitable for mixing in water for oral taking.And the traditional cake processed of Poria, the Production Time such as to cook congee are long, and not easily store, inconvenient family uses.
Summary of the invention
In order to solve the problem, on the one hand, embodiments provide the granule that a kind of Poria is made, it is with Poria and Folium Camelliae sinensis for primary raw material, and to be equipped with the Radix Codonopsis of integration of edible and medicinal herbs, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae and Pericarpium Citri Reticulatae be granular tea beverage prepared by auxiliary material.Its formula is developed by ancient prescription agent, uses that modern in-depth manufacturing procedure is refining to be formed, and has that good health care effect, mouthfeel are good, color and luster coordinates the advantages such as soft, not stratified and deposit-free.On the other hand, the embodiment of the present invention additionally provides the preparation method of aforementioned particles, Poria raw material is after prepared by boil altogether with Radix Glycyrrhizae Preparata, decompose and precipitate with ethanol etc. in the method, the conversion ratio of Poria material composition improves 20-60%, the dissolution rate of the compositions such as pachyman enhances 30-60%, and tea granule can be made to be easy to absorption of human body when Instant Drinks.Described scheme is as follows:
On the one hand, embodiments provide a kind of tuckahoe teat granule, the raw material composition of this granule comprises: the adjuvant of Poria 80-100 weight portion, Folium Camelliae sinensis 10-20 weight portion, Radix Codonopsis 5-6 weight portion, Rhizoma Atractylodis Macrocephalae 4-5 weight portion, Radix Glycyrrhizae Preparata 3.5-5 weight portion, Pericarpium Citri Reticulatae 3-4 weight portion, gross mass 10-15%.Wherein, adjuvant is mainly binding agent and food additive, and food additive comprises essence and sweetener etc.Wherein, Poria through boiling altogether with Radix Glycyrrhizae Preparata, to decompose and the operation such as precipitate with ethanol obtains the extracting solution of high pachyman content, and Folium Camelliae sinensis, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae and Pericarpium Citri Reticulatae adopt common aqueous extract, make granule by after aforementioned two kinds of liquid mixing.
Wherein, the composition of the adjuvant in the embodiment of the present invention is counted with mass percentage: dextrin 10-12%, essence 0.2-0.3%, sweetener 0.2-0.3%.
On the other hand, embodiments provide the preparation method of aforementioned particles, comprise the following steps:
(1) soak: the Poria after pulverizing is joined in the water of 1:12-15 times of weight and soaks, soaked rear filtration.
(2) heat is carried: in the filtering residue that step (1) obtains, add Radix Glycyrrhizae Preparata aqueous extract by proportioning, 5-6 hour is extracted at 95-100 DEG C of temperature, add the filtrate that step (1) obtains again, boil 16-22 hour, obtain Poria Radix Glycyrrhizae and close liquid; Wherein, employing of the present invention and Radix Glycyrrhizae Preparata boil altogether, not only can improve the dissolution rate of pachyman 20-30%, also help the sublimation separation of Colophonium.Meanwhile, twice heat is adopted to carry the active substance fully extracted in Poria in this operation.
(3) be hydrolyzed: adopt papain to close liquid to the Poria Radix Glycyrrhizae that step (2) obtains and be hydrolyzed, be hydrolyzed rear filtration.
(4) precipitate with ethanol: add the ethanol that volumetric concentration is 65-75% in the filtrate that step (3) obtains, the volume ratio of the filtrate that the step (3) used obtains and ethanol is 1:1-2, heating and refluxing extraction 22-26 hour, reclaim ethanol after layering, refilter to obtain Poria extracting solution.
Wherein, because the Poria in raw material is the sclerotium of polypor, water insoluble; The method of use hydrolysis, precipitate with ethanol is decomposed and the molten object releasing Poria active substance to reach material (being mainly protein and Colophonium).Wherein, the concentration of ethanol needs strict control, is unfavorable for the separation of Colophonium, be unfavorable for the extraction of Poria material, and Extraction and separation effect is all better within the scope of 65-75% lower than 65% higher than 75%.Being preferably volumetric concentration is the ethanol of 70%.
(5) homogenizing is mixed: after Poria extracting solution step (4) obtained mixes by proportioning with Folium Camelliae sinensis, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae and Pericarpium Citri Reticulatae aqueous extract, homogenizing obtains mixed extract.
(6) granulate: mixed extract step (5) obtained, through heating concentrated (can carry out deactivation to enzyme), dry and after pulverizing, adds adjuvant by proportioning and allocates simultaneously, then through granulation and multiple dry after obtain finished product.
Wherein, step (1) specifically comprises: pulverize the Poria of high-quality for after 80-100 object fine powder, join at normal temperatures in the water of 1:12-15 times of weight and soak 6-8 hour, filter filtering residue and filtrate for subsequent use.
Wherein, the preparation method of Radix Glycyrrhizae Preparata aqueous extract is: joined by Radix Glycyrrhizae Preparata in the water of 1:8-10 times of weight and decoct 3-5 hour, filters to obtain Radix Glycyrrhizae Preparata aqueous extract.
Wherein, the hydrolysising condition of step (3) is: the consumption of papain is 95-100U/g, and hydrolysis temperature is 50-55 DEG C, and hydrolysis time is 28-32 minute, pH is that 5.5-6.0(is preferably 6.0).
Wherein, step (5) specifically comprises: Poria extracting solution is obtained mixed extract with Folium Camelliae sinensis, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae and Pericarpium Citri Reticulatae aqueous extract after 1:0.3-0.5 mixing homogenizing.Wherein, the preparation method of Folium Camelliae sinensis, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae and Pericarpium Citri Reticulatae aqueous extract is: by proportioning, raw material tea leaf, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae and Pericarpium Citri Reticulatae and water are decocted 35-40 minute by the weight ratio of 1:10-12, filter, the weight ratio that filtering residue and water press 1:5-6 decocts 25-30 minute, filter, after merging twice filtrate filter or leave standstill obtain Folium Camelliae sinensis, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae and Pericarpium Citri Reticulatae aqueous extract.
Wherein, step (6) specifically comprises: carry out drying after the mixed extract that step (5) obtains is concentrated into the 30-50% of cumulative volume, to control water content for 10-13%, pulverize as 120-150 object granule again, granulate after adding adjuvant by proportioning, then do to control moisture again in 50-55 DEG C and be less than or equal to 3%.Wherein, the granule adopting the method to prepare is easy to absorption of human body when Instant Drinks.
Further, the preparation method of the tuckahoe teat granule that the embodiment of the present invention provides, specifically comprises:
(1) soak: the Poria of high-quality is pulverized as after 80-100 object fine powder, joins at normal temperatures in the water of 1:12-15 times of weight and soak 6-8 hour, filter filtering residue and filtrate for subsequent use.
(2) heat is carried: in the filtering residue that step (1) obtains, add Radix Glycyrrhizae Preparata aqueous extract (through being scaled the 0.4-0.5 of Poria raw material dry weight doubly) by proportioning, 5-6 hour is extracted at 95-100 DEG C of temperature, add the filtrate that step (1) obtains again, boil 16-22 hour, obtain Poria Radix Glycyrrhizae and close liquid.Wherein, the preparation method of Radix Glycyrrhizae Preparata aqueous extract is: joined by Radix Glycyrrhizae Preparata in the water of 1:8-10 times of weight and decoct 3-5 hour, filters to obtain Radix Glycyrrhizae Preparata aqueous extract.
(3) be hydrolyzed: adopt papain to close liquid to the Poria Radix Glycyrrhizae that step (2) obtains and be hydrolyzed, be hydrolyzed rear filtration, hydrolysising condition is: the consumption of papain is 95-100U/g, hydrolysis temperature is 50-55 DEG C, hydrolysis time is 28-32 minute, pH is 5.5-6.0;
(4) precipitate with ethanol: add the ethanol that volumetric concentration is 65-75% in the filtrate that step (3) obtains, the volume ratio of filtrate and ethanol is 1:1-2, heating and refluxing extraction 22-26 hour, reclaims the ethanol on upper strata after layering, take off layer and refilter to obtain Poria extracting solution.
(5) homogenizing is mixed: Poria extracting solution step (4) obtained obtains mixed extract with Folium Camelliae sinensis, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae and Pericarpium Citri Reticulatae aqueous extract after 1:0.3-0.4 mixing homogenizing.Wherein, the preparation method of Folium Camelliae sinensis, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae and Pericarpium Citri Reticulatae aqueous extract is: get Folium Camelliae sinensis, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae and Pericarpium Citri Reticulatae by proportioning, add raw material tea leaf, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae and Pericarpium Citri Reticulatae gross weight 1:10-12 soak by water 35-40 minute doubly, filter, the weight ratio that filtering residue and water press 1:5-6 decocts 25-30 minute, filter, after merging twice filtrate filter or leave standstill obtain Folium Camelliae sinensis, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae and Pericarpium Citri Reticulatae aqueous extract.
(6) granulate: after the mixed extract that step (5) obtains is concentrated into the 30-50% of cumulative volume, carry out drying, to control water content for 10-13%, pulverize as 120-150 object granule again, make 20-30 object granule after adding auxiliary materials and mixing by proportioning, then do to control moisture again in 50-55 DEG C and be less than or equal to 3%.
In the tuckahoe teat granule provided of the present invention, each raw material is described below:
Poria (formal name used at school: Poria cocos (Schw.) Wolf.) has another name called: Fu Tu, Poria, and Fu Ling, Fu Ling, volt Tu, pine fat, deep red morning lies prostrate tire, Poria, Fu rabbit, loose potato, Masson Pine potato, Song Ling.Medicinal part is the sclerotium of On Polyporaceae Poria.There is promoting diuresis to eliminate damp pathogen, spleen invigorating, the effect of calming the nerves.Can also be made into powdery be used for Ms hobby cleawhite pack.Distributed areas: Jilin, Anhui, Zhejiang, Fujian, Henan, Hubei, Guangxi, Sichuan, Guizhou, Yunnan.Ancients claim Poria to be " when four god medicine ", because its effect widely, regardless of the four seasons, by it and various compatibility of drugs, no matter cold, temperature, wind, wet all diseases, can play its unique effects.Poria sweet in the mouth, light, property are put down, and are used as medicine and have the function of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.But deficiency and coldness essence is sliding or collapse of QI person avoids clothes.
Folium Camelliae sinensis, latin name Camellia sinensis (L.) O.Kuntze, Folium Camelliae sinensis is really containing biochemical closely-related with health, Folium Camelliae sinensis not only have refresh oneself clear away heart-fire, clearing away summer-heat, eliminate indigestion and phlegm, go greasy fat-reducing, the relieving restlessness that clears away heart-fire, the pharmacological action such as removing toxic substances relieving alcoholic intoxication, promoting the production of body fluid to quench thirst, pathogenic fire reducing improving eyesight, dysentery relieving dehumidifying, also to modern diseases, as diseases such as Radiation sickness, cardiovascular and cerebrovascular disease, cancers, there is certain pharmacological effect.Meanwhile, Folium Camelliae sinensis has special delicate fragrance, is very suitable for drinking.
Radix Glycyrrhizae Preparata (RADIX GLYCYRRHIZAE PREPARATA), it is leguminous plant, Radix Glycyrrhizae Preparata is the Radix Glycyrrhizae of smoking with honey, be commonly called as the process of preparing Chinese medicine, put in pot by Mel exactly and be smelt middle honey, use slow fire instead and add Radix Glycyrrhizae sheet and stir evenly, 3-5 min takes the dish out of the pot, put when barn or 60 DEG C, baking oven are dried to tack-free and take out, cool.Radix Glycyrrhizae Preparata is similar round or oval section, and the brown or taupe brown of surface red, micro-glossy, tangent plane is yellow to buff, and cambium ring is obvious, ray irradiation shape.Zhigancao decoction has benefiting qi and nourishing yin, and activate yang multiple arteries and veins therapeutic efficiency.
Radix Codonopsis is the dry root of Campanulaceae Radix Codonopsis, element flower Radix Codonopsis or radix codonpsis tangshen etc.Radix Codonopsis sweet in the mouth, property is put down.Have invigorating the spleen and replenishing QI, quench the thirst, the effect such as spleen invigorating lung benefiting, nourishing blood to promote the production of body fluid.For deficiency of both the splenic and pulmonary QI, lack of appetite asthenia, cough dyspnea due to deficiency, insufficiency of vital energy and blood, shallow complexion, shortness of breath and palpitation, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, and lazy speech is losed heart, and myasthenia of limbs, is off one's feed, the deficiency of vital energy, and gas Tianjin two is empty, and QI and blood is two loses and the disease such as blood deficiency and yellow complexion.
The Rhizoma Atractylodis Macrocephalae, another name Rhizoma Atractylodis Macrocephalae, the winter Rhizoma Atractylodis Macrocephalae, wash rice art, poplar small wooden raft, Wu Shu, sheet art, etc., formal name used at school: Atractylodes macrocephala.Belong to Compositae, the Rhizoma Atractylodis Macrocephalae belongs to herbaceos perennial, root stock nodositas.Stem is upright, the long branch from middle and lower part usually, whole Glabrous.The nice and cool weather of happiness, is used as medicine with rhizome, has multinomial medicinal function.The Rhizoma Atractylodis Macrocephalae has invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis and the effect such as antiabortive, and for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement etc.
Pericarpium Citri Reticulatae, another name: Pericarpium Citri tangerinae, expensive old, Folium Styracis Suberifoliae, Fructus Citri tangerinae skin, extensively Pericarpium Citri tangerinae, Pericarpium Citri tangerinae, Citrus chachiensis Hort. C. Suavissima Tanaka, Pericarpium citri reticuatae chachiensis.For the mature peel of rutaceae orange and variety thereof.The evergreen dungarunga of Fructus Citri tangerinae or shrub, cultivate in hills, the littoral or Plain of low mountain zone, rivers and lakes.Be distributed in each department on the south the Changjiang river.During 10 to December fruit maturation, take fruit, strip peel, dry in the shade or aeration-drying.Cure mainly regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.
Poria raw material in the tuckahoe teat granule that the embodiment of the present invention provides is after prepared by boil altogether with Radix Glycyrrhizae Preparata, decompose and precipitate with ethanol etc., relative to existing processing method, the conversion ratio of Poria material composition improves 20-60%, the dissolution rate of the compositions such as pachyman enhances 30-60%, not only increase the conversion of material and the stripping of effective ingredient, also eliminate the Colophonium in Poria, and this tea granule can be made to be of value to absorption of human body when Instant Drinks, be more conducive to health.The effect of this tuckahoe teat granule is: in benefit, beneficial gas ﹑ refreshment is carried refreshing ﹑ and is good for the brain and enhancing intelligence ﹑ bright order ﹑ spleen invigorating that clears away heart-fire and opens stomach ﹑ promoting diuresis to eliminate damp pathogen, the stagnant ﹑ heat-clearing and toxic substances removing of helping digestion and improve immune function of human body, effect such as fat-reducing anti-cancer etc.
Detailed description of the invention
For making the object, technical solutions and advantages of the present invention clearly, below embodiment of the present invention is described further in detail.
As shown in table 1, table 1 is the proportioning raw materials of multiple tuckahoe teat granule:
Table 1
Wherein, Poria, through the Poria extracting solution selecting material, high pachyman content is carried, is hydrolyzed and obtained after precipitate with ethanol to pulverizing, immersion, heat, carries the dissolution rate adopting in process and boil to improve pachyman with Radix Glycyrrhizae Preparata aqueous extract altogether in heat; Folium Camelliae sinensis, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae and Pericarpium Citri Reticulatae adopt common aqueous extract, Poria extracting solution and Folium Camelliae sinensis, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae and Pericarpium Citri Reticulatae aqueous extract through mixing homogenizing, concentrated, dry and allocate with adjuvant after pulverizing, then through granulate and multiple do after obtain finished product.
Particularly, the preparation method of tuckahoe teat granule that provides of embodiment 2 is as follows:
1 selects material: select pure white without sulfur, and the high-quality Poria 87Kg going rotten rotten Wu Chong Zhu ﹑ is raw material.
2 pulverize: pulverized by Poria, and the extraction ratio of raw material increases with the quality increase of smashing fineness, and degree of grinding is advisable with 80-100 order.3 soak: the Poria after pulverizing to be joined in the water of 14 times of weight (1218Kg) soak at room temperature 7 hours, filter filtering residue and filtrate for subsequent use.4 heat are carried: add liquorice beverage extracting solution (through being scaled the 0.4-0.5 of Poria raw material dry weight doubly) after Poria raw material (i.e. the filtering residue of the step 3) drainage after step 3 being soaked, heating extraction 5 hours at the temperature of 100 DEG C, add the immersion water (i.e. the filtrate of step 3) of Poria again, boil 20 hours, obtain Poria Radix Glycyrrhizae and close liquid.Wherein, the preparation method of liquorice beverage extracting solution is: get Radix Glycyrrhizae Preparata 4 Kg, decocts 4 hours, filter to obtain Radix Glycyrrhizae extract in the water of 10 times of weight (40Kg).5 hydrolysis: adopt papain to close liquid to the Poria Radix Glycyrrhizae that step 4 obtains and be hydrolyzed, the consumption of papain is 100U/g, and hydrolysis temperature is 55 DEG C, and hydrolysis time is 30 minutes, and pH is 6.0, stirred leaching liquid after hydrolysis.6 precipitate with ethanol: use the ethanol of volumetric concentration 70% as solvent, the volume ratio of the filtrate that step 5 obtains and ethanol is 1:1-2, and heating and refluxing extraction 25 hours, reclaims the ethanol on upper strata after layering, takes off layer and refilters to obtain Poria extracting solution.
7 mixing homogenizing: get raw material tea leaf 15Kg, Radix Codonopsis 5Kg, Rhizoma Atractylodis Macrocephalae 5Kg and Pericarpium Citri Reticulatae 4Kg, join in the water (290Kg) of raw material 10 times of weight and decoct 35 minutes, filter, the water (174Kg) of filtering residue and raw material 6 times of weight decocts 30 minutes, filters and obtain Folium Camelliae sinensis, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae and Pericarpium Citri Reticulatae aqueous extract after merging twice filtrate; Twice decoction is left 40-50% to water liquid and is advisable.Obtain mixed extract after the Folium Camelliae sinensis of Poria extracting solution step 6 obtained and aforementioned preparation, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae and Pericarpium Citri Reticulatae aqueous extract mixing homogenizing, the weight ratio through conversion Poria extracting solution and Folium Camelliae sinensis, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae and Pericarpium Citri Reticulatae aqueous extract is 1:0.3-0.5.
8 concentrate: the mixed extract that step 7 obtains is evaporated to 40% of original volume, in thick matter shape, obtains concentrated solution.
9 is dry: it is dry according to a conventional method that concentrated solution step 8 obtained drops into spray dryer, and controlling water content is 12%.
10 pulverize: with the pulverizer of 120 mesh sieves, step 9 is obtained dried feed and pulverize, obtain concentrate.
11 allotments: the concentrate obtained in step 10 adds dextrin 13.4 Kg, essence 0.24 Kg and sweetener 0.36 Kg mixes all repeatedly.
12 granulate: spice step 11 the obtained granulator of 30 mesh sieves is granulated, and gets grain between 20-30 order.
13 is multiple dry: getting granulate drying machine in step 12 granulation process in 50 DEG C of dryings, is good to moisture≤3%.14 packagings: it is qualified that granule processing technology completes detection, by every bag of 5 grams of vacuum packagings.
Wherein, use the product advantage of this method of granulating to be: effective, mouthfeel good, color and luster coordinate soft, not stratified, deposit-free.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (9)

1. a tuckahoe teat granule, it is characterized in that, its raw material composition comprises: the adjuvant of Poria 80-100 weight portion, Folium Camelliae sinensis 10-20 weight portion, Radix Codonopsis 5-6 weight portion, Rhizoma Atractylodis Macrocephalae 4-5 weight portion, Radix Glycyrrhizae Preparata 3.5-5 weight portion, Pericarpium Citri Reticulatae 3-4 weight portion, gross mass 10-15%.
2. tuckahoe teat granule according to claim 1, is characterized in that, the composition of described adjuvant is counted with mass percentage: dextrin 10-12%, essence 0.2-0.3%, sweetener 0.2-0.3%.
3. the preparation method of tuckahoe teat granule as claimed in claim 1 or 2, it is characterized in that, described method comprises:
(1) soak: the Poria after pulverizing is joined in the water of 1:12-15 times of weight and soaks, soaked rear filtration;
(2) heat is carried: in the filtering residue that step (1) obtains, add Radix Glycyrrhizae Preparata aqueous extract by proportioning, 5-6 hour is extracted at 95-100 DEG C of temperature, add the filtrate that step (1) obtains again, boil 16-22 hour, obtain Poria Radix Glycyrrhizae and close liquid;
(3) be hydrolyzed: adopt papain to close liquid to the Poria Radix Glycyrrhizae that step (2) obtains and be hydrolyzed, be hydrolyzed rear filtration;
(4) precipitate with ethanol: add the ethanol that volumetric concentration is 65-75% in the filtrate that step (3) obtains, the volume ratio of described filtrate and ethanol is 1:1-2, heating and refluxing extraction 22-26 hour, reclaims ethanol after layering, refilters to obtain Poria extracting solution;
(5) homogenizing is mixed: after Poria extracting solution step (4) obtained mixes by proportioning with Folium Camelliae sinensis, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae and Pericarpium Citri Reticulatae aqueous extract, homogenizing obtains mixed extract;
(6) granulate: mixed extract step (5) obtained, through concentrated, dry and after pulverizing, add adjuvant by proportioning and allocates, then through granulate and multiple do after obtain finished product.
4. the preparation method of tuckahoe teat granule according to claim 3, it is characterized in that, step (1) specifically comprises: pulverized by the Poria of high-quality as after 80-100 object fine powder, join at normal temperatures in the water of 1:12-15 times of weight and soak 6-8 hour, filter filtering residue and filtrate for subsequent use.
5. the preparation method of tuckahoe teat granule according to claim 4, is characterized in that, the preparation method of described Radix Glycyrrhizae Preparata aqueous extract is: joined by Radix Glycyrrhizae Preparata in the water of 1:8-10 times of weight and decoct 3-5 hour, filters to obtain described Radix Glycyrrhizae Preparata aqueous extract.
6. the preparation method of tuckahoe teat granule according to claim 5, it is characterized in that, the hydrolysising condition of step (3) is: the consumption of papain is 95-100U/g, and hydrolysis temperature is 50-55 DEG C, hydrolysis time is 28-32 minute, pH is 5.5-6.0.
7. the preparation method of tuckahoe teat granule according to claim 6, it is characterized in that, step (5) specifically comprises: Poria extracting solution step (4) obtained obtains described mixed extract with Folium Camelliae sinensis, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae and Pericarpium Citri Reticulatae aqueous extract after 1:0.3-0.5 mixing homogenizing; The preparation method of described Folium Camelliae sinensis, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae and Pericarpium Citri Reticulatae aqueous extract is: by proportioning, raw material tea leaf, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae and Pericarpium Citri Reticulatae and water are decocted 35-40 minute by the weight ratio of 1:10-12, filter, the weight ratio that filtering residue and water press 1:5-6 decocts 25-30 minute, filter, merge twice filtrate and obtain described Folium Camelliae sinensis, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae and Pericarpium Citri Reticulatae aqueous extract.
8. the preparation method of tuckahoe teat granule according to claim 7, it is characterized in that, step (6) specifically comprises: carry out drying after the mixed extract that step (5) obtains is concentrated into the 30-50% of cumulative volume, to control water content for 10-13%, pulverize as 120-150 object granule again, granulate after adding adjuvant by proportioning, then do to control moisture again in 50-55 DEG C and be less than or equal to 3%.
9. the preparation method of tuckahoe teat granule according to claim 3, is characterized in that, described method specifically comprises:
(1) soak: the Poria of high-quality is pulverized as after 80-100 object fine powder, joins at normal temperatures in the water of 1:12-15 times of weight and soak 6-8 hour, filter filtering residue and filtrate for subsequent use;
(2) heat is carried: in the filtering residue that step (1) obtains, add Radix Glycyrrhizae Preparata aqueous extract by proportioning, 5-6 hour is extracted at 95-100 DEG C of temperature, add the filtrate that step (1) obtains again, boil 16-22 hour, obtain Poria Radix Glycyrrhizae and close liquid, the preparation method of described Radix Glycyrrhizae Preparata aqueous extract is: joined by Radix Glycyrrhizae Preparata in the water of 1:8-10 times of weight and decoct 3-5 hour, filters to obtain described Radix Glycyrrhizae Preparata aqueous extract;
(3) be hydrolyzed: adopt papain to close liquid to the Poria Radix Glycyrrhizae that step (2) obtains and be hydrolyzed, be hydrolyzed rear filtration, hydrolysising condition is: the consumption of papain is 95-100U/g, hydrolysis temperature is 50-55 DEG C, hydrolysis time is 28-32 minute, pH is 5.5-6.0;
(4) precipitate with ethanol: add the ethanol that volumetric concentration is 65-75% in the filtrate that step (3) obtains, the volume ratio of described filtrate and ethanol is 1:1-2, heating and refluxing extraction 22-26 hour, reclaims ethanol after layering, refilters to obtain Poria extracting solution;
(5) homogenizing is mixed: Poria extracting solution step (4) obtained obtains described mixed extract with Folium Camelliae sinensis, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae and Pericarpium Citri Reticulatae aqueous extract after 1:0.3-0.5 mixing homogenizing, the preparation method of described Folium Camelliae sinensis, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae and Pericarpium Citri Reticulatae aqueous extract is: by proportioning, raw material tea leaf, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae and Pericarpium Citri Reticulatae and water are decocted 35-40 minute by the weight ratio of 1:10-12, filter, the weight ratio that filtering residue and water press 1:5-6 decocts 25-30 minute, filter, merge twice filtrate and obtain described Folium Camelliae sinensis, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae and Pericarpium Citri Reticulatae aqueous extract;
(6) granulate: after the mixed extract that step (5) obtains is concentrated into the 30-50% of cumulative volume, carry out drying, to control water content for 10-13%, pulverize as 120-150 object granule again, make 20-30 object granule after adding auxiliary materials and mixing by proportioning, then do to control moisture again in 50-55 DEG C and be less than or equal to 3%.
CN201410556028.3A 2014-10-20 2014-10-20 Poria cocos tea particle and preparation method thereof Pending CN104352655A (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105230888A (en) * 2015-11-09 2016-01-13 莫永森 Formula of tea with sugar and capable of detoxification as well as preparation method of sugarless paste and preparation method of granules
CN105410910A (en) * 2015-11-27 2016-03-23 黑龙江众生生物工程有限公司 Frullania tamarisci heart clearing and eyesight improving granule and preparation method thereof
CN105410909A (en) * 2015-11-27 2016-03-23 黑龙江众生生物工程有限公司 Hibiscus mutabilis fat reducing and weight losing granule and preparation method thereof
CN105476019A (en) * 2015-11-27 2016-04-13 黑龙江众生生物工程有限公司 Caesalpinia millettii spleen-invigorating stomach-protection particle and preparation method thereof
CN111053858A (en) * 2020-01-20 2020-04-24 辽宁中医药大学 Spleen-tonifying and probiotic health-care tea containing traditional Chinese medicine codonopsis pilosula and preparation method thereof

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105230888A (en) * 2015-11-09 2016-01-13 莫永森 Formula of tea with sugar and capable of detoxification as well as preparation method of sugarless paste and preparation method of granules
CN105410910A (en) * 2015-11-27 2016-03-23 黑龙江众生生物工程有限公司 Frullania tamarisci heart clearing and eyesight improving granule and preparation method thereof
CN105410909A (en) * 2015-11-27 2016-03-23 黑龙江众生生物工程有限公司 Hibiscus mutabilis fat reducing and weight losing granule and preparation method thereof
CN105476019A (en) * 2015-11-27 2016-04-13 黑龙江众生生物工程有限公司 Caesalpinia millettii spleen-invigorating stomach-protection particle and preparation method thereof
CN111053858A (en) * 2020-01-20 2020-04-24 辽宁中医药大学 Spleen-tonifying and probiotic health-care tea containing traditional Chinese medicine codonopsis pilosula and preparation method thereof

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Application publication date: 20150218