CN104352553A - Medicine with functions of promoting blood circulation to remove blood stasis and regulating immune functions and preparation method - Google Patents
Medicine with functions of promoting blood circulation to remove blood stasis and regulating immune functions and preparation method Download PDFInfo
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- CN104352553A CN104352553A CN201410723659.XA CN201410723659A CN104352553A CN 104352553 A CN104352553 A CN 104352553A CN 201410723659 A CN201410723659 A CN 201410723659A CN 104352553 A CN104352553 A CN 104352553A
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- medicine
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- polysaccharide
- blood circulation
- blood stasis
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- 239000003814 drug Substances 0.000 title claims abstract description 18
- 239000008280 blood Substances 0.000 title claims abstract description 17
- 210000004369 blood Anatomy 0.000 title claims abstract description 17
- 230000017531 blood circulation Effects 0.000 title claims abstract description 12
- 230000001737 promoting effect Effects 0.000 title claims abstract description 12
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 230000036737 immune function Effects 0.000 title abstract 2
- 230000001105 regulatory effect Effects 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- 150000004676 glycans Chemical class 0.000 claims abstract description 26
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 26
- 239000005017 polysaccharide Substances 0.000 claims abstract description 26
- 229930003944 flavone Natural products 0.000 claims abstract description 18
- 235000011949 flavones Nutrition 0.000 claims abstract description 18
- 230000036039 immunity Effects 0.000 claims abstract description 10
- 239000008187 granular material Substances 0.000 claims abstract description 7
- 241001247821 Ziziphus Species 0.000 claims description 17
- 239000008518 lycium barbarum polysaccharide Substances 0.000 claims description 17
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 claims description 17
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 claims description 16
- 150000002212 flavone derivatives Chemical class 0.000 claims description 16
- 238000001035 drying Methods 0.000 claims description 10
- 230000001954 sterilising effect Effects 0.000 claims description 10
- 238000005516 engineering process Methods 0.000 claims description 7
- 239000012531 culture fluid Substances 0.000 claims description 6
- 241000233866 Fungi Species 0.000 claims description 5
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 claims description 5
- 239000002131 composite material Substances 0.000 claims description 5
- 238000000855 fermentation Methods 0.000 claims description 5
- 230000004151 fermentation Effects 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- 238000004806 packaging method and process Methods 0.000 claims description 5
- 238000010298 pulverizing process Methods 0.000 claims description 5
- 238000000746 purification Methods 0.000 claims description 5
- 238000012807 shake-flask culturing Methods 0.000 claims description 5
- 238000004659 sterilization and disinfection Methods 0.000 claims description 5
- 238000001291 vacuum drying Methods 0.000 claims description 5
- 230000000694 effects Effects 0.000 abstract description 6
- 208000007502 anemia Diseases 0.000 abstract description 3
- 230000001914 calming effect Effects 0.000 abstract description 3
- 230000004438 eyesight Effects 0.000 abstract description 3
- 210000004185 liver Anatomy 0.000 abstract description 3
- 210000005036 nerve Anatomy 0.000 abstract description 3
- 230000029087 digestion Effects 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 244000241838 Lycium barbarum Species 0.000 abstract 2
- 235000015459 Lycium barbarum Nutrition 0.000 abstract 2
- 241000219780 Pueraria Species 0.000 abstract 2
- 240000008866 Ziziphus nummularia Species 0.000 abstract 2
- 150000002213 flavones Chemical class 0.000 abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 230000032683 aging Effects 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 230000003203 everyday effect Effects 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 230000002040 relaxant effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 description 5
- OAABHEHWRQAHEJ-UHFFFAOYSA-N butan-1-ol;chloroform Chemical compound ClC(Cl)Cl.CCCCO OAABHEHWRQAHEJ-UHFFFAOYSA-N 0.000 description 4
- 206010016256 fatigue Diseases 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000003064 anti-oxidating effect Effects 0.000 description 2
- 230000002443 hepatoprotective effect Effects 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 241000721047 Danaus plexippus Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 208000033065 inborn errors of immunity Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 208000028529 primary immunodeficiency disease Diseases 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a medicine with functions of promoting blood circulation to remove blood stasis and regulating immune functions and a preparation method. The medicine comprises 25-60wt% of lycium barbarum polysaccharides, 20-55wt% of jujube date polysaccharides and 10-55wt% of pueraria flavones. The preparation method is characterized by firstly extracting lycium barbarum polysaccharides, jujube date polysaccharides and pueraria flavones respectively and preparing the medicine in proportion. The medicine is low in cost, does not have any toxic or side effect, has the functions of promoting blood circulation to remove blood stasis, resisting oxidation, aging and fatigues, benefiting qi and nourishing blood, reducing lipid and glucose, improving anemia, calming the mind and the nerves, protecting the liver to improve eyesight, aiding digestion and relaxing the bowels, and has obvious effects on enhancement and regulation of immunity, resistance to allergy and invigoration of brains. 2-3 granules of the medicine are taken by the adults every day, 1-2 granules each time, and the medicine can be taken for a long term.
Description
Technical field:
The present invention relates to a kind of Chinese medicine, particularly the medicine of a kind of blood circulation promoting and blood stasis dispelling, immunity moderation function and preparation method.
Background technology:
At present, people, due to the large impact of climate, diet and operating pressure, are in sub-health state substantially, and hypoimmunity, anemia, fatiguability, easy old and feeble Liver and kidney are uncomfortable, and treatment Western medicine does not have better method at present, cures the symptoms, not the disease.To the many toxic side effects of human body, though short run effect is good, also large to human injury.Some Chinese formulated products is lost basis effect, ignores extensive knowledge and profound scholarship and the elite place of monarch.
Summary of the invention:
Content of the present invention is the deficiency overcoming existing Chinese patent medicine technology, one is provided to have no side effect, improve body mass, blood circulation promoting and blood stasis dispelling, antioxidation, defying age, resisting fatigue, benefiting qi and nourishing blood, the nerves calming, hepatoprotective improving eyesight, regulate the conditioning medicine and preparation method thereof of Liver and kidney, enhancing and immunity moderation.
The object of the present invention is achieved like this: it is by lycium barbarum polysaccharide, red jujube polysaccharide, Radix Puerariae flavone forms, its percentage by weight is: lycium barbarum polysaccharide 25%-60%, red jujube polysaccharide 20%-55%, Radix Puerariae flavone 10%-50%, its technique comprises the following steps, the liquid submerged fermentation processing technology of fungus, comprise lycium barbarum polysaccharide, red jujube polysaccharide and Radix Puerariae flavone, specific as follows: strain → slant culture 10-20 days → shake-flask culture 2-5 days → fermentor cultivation 1-5 days → filter mycelium, refine the mycelium → purification polysaccharide → drying → pulverizing → composite → sterilizing → fill → packaging in culture fluid simultaneously.
Object of the present invention also can realize in the following manner, and drying process is vacuum drying box ozone sterilization, and the ratio of filter liquor and chloroform butanol solution is 4: 1, and lycium barbarum polysaccharide, red jujube polysaccharide, Radix Puerariae flavone granule are 80-100 order.
Advantage of the present invention is: cost is low, without any side effects, can blood circulation promoting and blood stasis dispelling, antioxidation, defying age, resisting fatigue, benefiting qi and nourishing blood, blood fat reducing, blood sugar lowering, improve anemia, the nerves calming, hepatoprotective improving eyesight, aid digestion, logical stool, strengthen and immunity moderation, antiallergic, brain-strengthening all has remarkable result.
Detailed description of the invention:
Embodiment one:
The percentage by weight of various composition is, lycium barbarum polysaccharide 25, red jujube polysaccharide 55, Radix Puerariae flavone 20.Its technique comprises the following steps, and the liquid submerged fermentation processing technology of fungus, comprises lycium barbarum polysaccharide, red jujube polysaccharide and Radix Puerariae flavone, specific as follows:
Strain → slant culture 10-20 days → shake-flask culture 2-5 days → fermentor cultivation 1-5 days → filter mycelium, refine the mycelium → purification polysaccharide → drying → pulverizing → composite → sterilizing → fill → packaging in culture fluid simultaneously.
Object of the present invention also can realize in the following manner, and drying process is vacuum drying box ozone sterilization, and the ratio of filter liquor and chloroform butanol solution is 4: 1, and lycium barbarum polysaccharide, red jujube polysaccharide, Radix Puerariae flavone granule are 80-100 order.
Embodiment two:
The percentage by weight of various composition is, lycium barbarum polysaccharide 60, red jujube polysaccharide 30, Radix Puerariae flavone 10.Its technique comprises the following steps, and the liquid submerged fermentation processing technology of fungus, comprises lycium barbarum polysaccharide, red jujube polysaccharide and Radix Puerariae flavone, specific as follows:
Strain → slant culture 10-20 days → shake-flask culture 2-5 days → fermentor cultivation 1-5 days → filter mycelium, refine the mycelium → purification polysaccharide → drying → pulverizing → composite → sterilizing → fill → packaging in culture fluid simultaneously.
Object of the present invention also can realize in the following manner, and drying process is vacuum drying box ozone sterilization, and the ratio of filter liquor and chloroform butanol solution is 4: 1, and lycium barbarum polysaccharide, red jujube polysaccharide, Radix Puerariae flavone granule are 80-100 order.
Embodiment three:
The percentage by weight of various composition is, lycium barbarum polysaccharide 25, red jujube polysaccharide 20, Radix Puerariae flavone 55.Its technique comprises the following steps, and the liquid submerged fermentation processing technology of fungus, comprises lycium barbarum polysaccharide, red jujube polysaccharide and Radix Puerariae flavone, specific as follows:
Strain → slant culture 10-20 days → shake-flask culture 2-5 days → fermentor cultivation 1-5 days → filter mycelium, refine the mycelium → purification polysaccharide → drying → pulverizing → composite → sterilizing → fill → packaging in culture fluid simultaneously.
Object of the present invention also can realize in the following manner, and drying process is vacuum drying box ozone sterilization, and the ratio of filter liquor and chloroform butanol solution is 4: 1, and lycium barbarum polysaccharide, red jujube polysaccharide, Radix Puerariae flavone granule are 80-100 order.Namely the present invention is realized.
Claims (5)
1. the medicine of a blood circulation promoting and blood stasis dispelling, immunity moderation function and preparation method, it is characterized in that: it is made up of lycium barbarum polysaccharide, red jujube polysaccharide, Radix Puerariae flavone, its percentage by weight is, lycium barbarum polysaccharide 25-60%, red jujube polysaccharide 20-55%, Radix Puerariae flavone 10-50%.
2. the medicine of a kind of blood circulation promoting and blood stasis dispelling, immunity moderation function and preparation method according to claim 1, it is characterized in that: the liquid submerged fermentation processing technology of fungus, comprise lycium barbarum polysaccharide, red jujube polysaccharide and Radix Puerariae flavone, specific as follows: strain → slant culture 10-20 days → shake-flask culture 2-5 days → fermentor cultivation 1-5 days → filter mycelium, to refine the mycelium → purification polysaccharide → drying → pulverizing → composite → sterilizing → fill → packaging in culture fluid simultaneously.
3. the medicine of a kind of blood circulation promoting and blood stasis dispelling according to claim 2, immunity moderation function and preparation method, is characterized in that; Cultivation temperature-6-68 DEG C, culture fluid pH value is at 4-7.5, and described drying process is vacuum drying box ozone sterilization.
4. the medicine of a kind of blood circulation promoting and blood stasis dispelling according to claim 2, immunity moderation function and preparation method, is characterized in that; Lycium barbarum polysaccharide, red jujube polysaccharide, Radix Puerariae flavone granule are 80-100 order.
5. the medicine of a kind of blood circulation promoting and blood stasis dispelling according to claim 2, immunity moderation function and preparation method, is characterized in that; Polyoses content by weight can more than 80%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410723659.XA CN104352553A (en) | 2014-12-04 | 2014-12-04 | Medicine with functions of promoting blood circulation to remove blood stasis and regulating immune functions and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410723659.XA CN104352553A (en) | 2014-12-04 | 2014-12-04 | Medicine with functions of promoting blood circulation to remove blood stasis and regulating immune functions and preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104352553A true CN104352553A (en) | 2015-02-18 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410723659.XA Pending CN104352553A (en) | 2014-12-04 | 2014-12-04 | Medicine with functions of promoting blood circulation to remove blood stasis and regulating immune functions and preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104352553A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101491331A (en) * | 2008-01-23 | 2009-07-29 | 邓喆铭 | Natural health beverage and manufacture method thereof |
| CN102321519A (en) * | 2011-09-27 | 2012-01-18 | 陕西科技大学 | Brewing method of red date medlar healthcare vinegar |
| CN103725468A (en) * | 2013-12-25 | 2014-04-16 | 黎志春 | Beautifying red wine and preparation method thereof |
-
2014
- 2014-12-04 CN CN201410723659.XA patent/CN104352553A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101491331A (en) * | 2008-01-23 | 2009-07-29 | 邓喆铭 | Natural health beverage and manufacture method thereof |
| CN102321519A (en) * | 2011-09-27 | 2012-01-18 | 陕西科技大学 | Brewing method of red date medlar healthcare vinegar |
| CN103725468A (en) * | 2013-12-25 | 2014-04-16 | 黎志春 | Beautifying red wine and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 彭游，等。: "葛根黄酮提取与保健功能研究进展", 《食品工业科技》 * |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| CB03 | Change of inventor or designer information |
Inventor after: Guo Xia Inventor before: Guo Xia Inventor before: Liu Fuling Inventor before: Yang Fuguo Inventor before: Li Zhicheng |
|
| COR | Change of bibliographic data | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20160120 Address after: 063000, building 401, room 402, Eastern Mansion, No. 152, Jianshe North Road, Tangshan City hi tech Zone, Hebei, Applicant after: Tangshan Yu Yu Biotechnology Co., Ltd. Address before: 063000 C, Eastern Mansion, Tangshan City hi tech Development Zone, Hebei, 401 Applicant before: Guo Xia |
|
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150218 |