CN104337793A - Formula of non-gelatin soft capsule shell - Google Patents
Formula of non-gelatin soft capsule shell Download PDFInfo
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- CN104337793A CN104337793A CN201410546365.4A CN201410546365A CN104337793A CN 104337793 A CN104337793 A CN 104337793A CN 201410546365 A CN201410546365 A CN 201410546365A CN 104337793 A CN104337793 A CN 104337793A
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Abstract
The invention discloses a formula of a non-gelatin soft capsule shell. The soft capsule shell is prepared from the following components in percentage by weight: 25-75 percent of modified starch, 10-30 percent of carrageenan, 10-25 percent of a plasticizer, 40-50 percent of water, 2-12 percent of a thickening agent and the balance of pigment which can be added according to the required color of the soft capsule pill. According to the formula, the main component gelatin of a traditional capsule shell material is replaced by modified starch and carrageenan, so that multiple defects of gelatin can be overcome, the modified starch has the characteristics of film performance, air resistance, adhesion and the like, has high safety performance and good elasticity, and has the dissolving speed superior to that of gelatin; the soft capsule prepared from modified starch and carrageenan has stable property, and cannot easily perform a crosslinking phenomenon; and the soft capsule prepared by using gelatin replacing materials does not have the problem of oxidation crosslinking, and an antioxidant does not need to be added.
Description
[technical field]
The present invention relates to technical field, particularly a kind of technical field of formula of non-soft-gelatin softgel shell that medical industry is produced.
[background technology]
Soft capsule refers to medicinal substances extract, liquid medicine or is sealed in the soft shell of hydrophilic the dosage form making spherical, oval or other shapes after mixing with proper auxiliary materials with dropping preparation method or pressing.Soft capsule is suitable for unstable effective substance, as to photaesthesia, volatility, the damp and hot instability of chance and oxidizable chemical composition, is also applicable to having uncomfortable taste and the bad effective substance smelling taste.
Soft capsule is the common formulations of supplementary and Western medicine, soft capsule is one of direction becoming innovation of Chinese medicinal dosage form, its capsule shells prescription comprises sizing material, plasticizer, water, additives four class material, and sizing material is the main component forming softgel shell, such as gelatin and gelatin substitution material etc.; Plasticizer commonly uses glycerol, polyhydric alcohol, is used alone or as a mixture; Additives comprise antiseptic, coloring agent, disintegrating agent, opacifier, antioxidant etc., to keep the quality stability of medicine and soft capsule dosage form.The formula of traditional non-soft-gelatin softgel shell mainly comprises gelatin, water, glycerol and selected pigment.
The sizing material of existing soft capsule shell comprises owing to using the shortcoming of gelatin: (1) cross-linking reaction: gelatin easily cross-linking reaction occurs, cause the instability of soft capsule, as aldehyde, polyphenol, reducing sugar, multi-charge cation, electrolyte, cation or anionic polymer etc., thus capsule mechanical performance or biological function are changed.
(2) safety problem: gelatin is a kind of material deriving from animal, raw material sources are in skin, the bone of animal, and gelatin is animal proteinum colloid, and fatty on a small quantity containing animal.In recent years, along with the generation of foot and mouth disease, bovine spongiform encephalopathy, bird flu, the safety of gelatin is more and more under suspicion, and it can not be accepted by some special cultural persons and vegetarian.
(3) disintegrate, leakage problems: within storage period, often occur underproof problem disintegration, this phenomenon mostly be gelatin aging crosslinked caused by.Storage characteristics is also poor, and long-term storage can cause softgel shell to become fragile because of dehydration.Due to the hydrophilic of gelatin, easily water suction, dehydration, prevent from absorbing the moisture in medicinal liquid in soft capsule and cause capsule deformation and seepage, loading amount defective, and gelatin can not be used for the parcel of hydrophilic or easy moisture absorption medicine.
[summary of the invention]
Object of the present invention solves the problems of the prior art exactly, and propose a kind of formula of non-soft-gelatin softgel shell, overcome a lot of shortcomings of gelatin, character is comparatively stable, not easily crosslinking phenomena occurs, safe and reliable, and storge quality is good.
For achieving the above object, the present invention proposes a kind of formula of non-soft-gelatin softgel shell, comprise modified starch, carrageenan, plasticizer, water, thickening agent, the percentage by weight of described each component is:
Modified starch 25 ~ 75%;
Carrageenan 10 ~ 30%;
Plasticizer 10 ~ 25%;
Water 40 ~ 50%;
Thickening agent 2 ~ 12%;
The pigment that the color of soft capsule soft gelatin capsule is as required added.
As preferably, described modified starch is PURE COTE PURE COTE B790, and carrageenan is the mixture of kappa-carrageenan and ι-carrageenan, and the ratio of kappa-carrageenan and ι-carrageenan is 1:1.
As preferably, described plasticizer is glycerol and sorbitol, and the ratio of glycerol and sorbitol is 0.4 ~ 0.6:0.4 ~ 0.7.
As preferably, described thickening agent is alginate jelly and hypromellose, and the ratio of sodium alginate and hypromellose is 8.5 ~ 11.5:0.005 ~ 0.015.
As preferably, the purified water that the water of described use is distillation equipment, prepared by ion-exchange unit or reverse osmosis equipment.
As preferably, described pigment determines the color of capsule, kind and the consumption of pigment are determined by capsule color, such as 1000 blue capsules need light blue 0.132g, whole red capsule needs carmine 0.128g, white portion does not use pigment and uses titanium dioxide mother solution, and all-transparent capsule does not then add pigment and titanium dioxide mother solution.
Non-soft-gelatin softgel shell, except considering all many-sides such as dissolubility, stability, bioavailability, safety and outward appearance, also will consider its processing characteristics.Common hydrophilic colloid comprises carrageenan, agar, alginate jelly, gellan gum, locust bean gum, HPMC modified starch, stroma starch etc., these common hydrophilic colloids are slightly worse than gelatin in combination property, usually there is the problems such as softness, intensity, transparency and stability in soft capsule prepared by the primary raw material being softgel shell with them, needs to adjust cooperation and technique.
A) character of modified starch
Starch is a kind of polysaccharide, independent native starch is generally difficult to prepare soft capsule, usual employing modified starch, or composite suitable edible glue and plasticizer, ative starch is after suitable chemical modification and enzyme modification process, change physics or the chemical characteristic of its original starch molecule to some extent, thus obtain suitable capsule casing material.The chemical modification of starch mainly contains etherificate, esterification, oxidation, cationization etc., and the enzyme that enzyme modification is conventional mainly contains hydrolytic enzyme, amylomaltase, glycogen branching enzyme, saccharifying enzyme etc.Modified starch is insoluble to cold water, ethanol and ether, is dissolved in or is scattered in boiling water, forms colloid solution or emulsion liquid.Become through modifying the character (elasticity, mechanical strength) that modified starch just has similar gelatin, the soft capsule selecting suitable modified starch to prepare can reach the characteristic of gelatin soft capsule 80% or higher.
The preferred chemical modification of starch comprises hydroxypropylation, acetylating, ethylization.The soft capsule wall thickness prepared in this way can be reduced to 100 μm, can 200% be extended to, intensity level reaches 5MPa, prepare soft capsule, the modified starches such as preferred hydroxypropyl, ethoxy, succinate and acetate, the gelation that Acid modified starch is stable under having low viscosity, high concentration, and there is good chewiness and elasticity.Research shows, starch softgel shell water content under different humidity condition is relatively stable, even if under higher levels of humidity condition, capsule still can keep good face shaping, soft durometer and suitable elastic stage, and be not clamminess phenomenon.Between month, careless oil is very easily oxidized in atmosphere, and under the factors such as air, light, heat, between the moon in starch soft capsule, the oxidation number not larger change of grass oil, illustrates that starch soft capsule has good barrier property, and more stable.
B) carrageenan
Modified starch can meet some characteristics preparing soft capsule, as good film property, adhesivity and flexibility, fast and the odorlessness etc. of rate of drying, but also may also exist that poor transparency, gelling temp are too high, melting temperature crosses the problems such as high simultaneously, suitable interpolation edible glue can mix softgel shell of good performance, what at present research was more is modified starch and carrageenan composite.
Carrageenan, also known as carrageenin, is the polysaccharide plant gum extracted from the thalassophytes such as Bostrychia montagnei, be divided into κ-, ι-, lambda-carrageenan 3 kinds, cooperative effect can be produced with many colloids, to increase system viscosity, gel strength and elasticity.Thickening and the gelling property of dissimilar carrageenan are very different.Such as, the hard gel that κ type carrageenan and potassium ion are formed, and ι and λ only has minimal effect.ι type carrageenan and calcium ion are done to form softness, whippy gel mutually, but salt does not affect for the character of λ type carrageenan.In most of the cases, λ type and κ type together use and obtain a kind of suspension or cream gel in milk systems.Carrageenan and composition thereof provides a large amount of benign species to cause producing the in extensive range in a large number and commercial product of complexity with the most applicable specific application of the combination property of satisfied uniqueness.Carrageenan is usual used as thickening agent, gellant, suspending agent, emulsifying agent and stabilizing agent etc. in food and medicine industry.
Carrageenan and modified starch composite being conducive to improve gelling performance and gelling temp, and the light transmittance of pure OK a karaoke club glued membrane is 78.5%, along with the interpolation of starch, light transmittance reduces gradually, this is because the degree of crystallinity of starch is higher, refraction and reflection occurs during light therethrough crystalline region, reduces light transmittance.
C) character of sorbitol
Sorbitol has another name called Sorbitol, Sorbitol, hexahydric alcohol etc., and outward appearance is white powder or crystalline powder, and molecular formula is C
6h
14o
6, be slightly soluble in ethanol and acetic acid.Have refrigerant sweet taste, sugariness is about the half of sucrose, and calorific value is close with sucrose.Soluble in water, be insoluble in organic solvent, it is acidproof, and heat resistance is good, and with aminoacid, protein etc. not easily play Maillard reaction.Have good performance of keeping humidity, the moisture that food can be made to keep certain, prevents drying, also can prevent sugar, the crystallizations such as salt, can keep sweet, acid, the balance of bitterness intensity, strengthen the local flavor of food, because it is nonvolatile polyhydric alcohol, so also have the function keeping food aroma.
Sorbitol has very large hygroscopicity, in aqueous not easily crystallization, and can boil together each metal ion species.Owing to not having reproducibility group in molecule, stable chemical nature under normal conditions, does not work with soda acid, is not subject to air oxidation, also not easily with soluble Amino compound, Mei Lade brown stain occurs.Sorbitol is to better heat stability, higher than corresponding sugar a lot, and mass fraction reaches more than 60% and is not just subject to microbial attack.Sorbitol enters energy metabolism in body, belongs to nutritive sweetener, but first its metabolic pathway is slowly diffusion and is oxidized to fructose by absorption, then is utilized, and participate in fructose metabolism approach, do not affect blood glucose value and glucose in urine, the sweeting agent that can be used as diabetes patient uses.
Sorbitol can reduce intracranial pressure, prevents edema, can be used as medicine and directly uses, and can be used for the normal edematous condition of cardiorenal function.Sorbitol can also promote gallbladder contraction and function of gallbladder promoting, and choleresis is increased; Stimulating pancreas secretion pancreatic lipase etc., promote also can accelerate insulin releasing small intestinal peristalsis and absorption, therefore can improve chronic liver and gall, gastrointestinal disease symptom.
The object adding plasticizer is the plasticity increasing colloidal materials, ensures that the softgel shell of soft capsule products is soft, high resilience.Conventional plasticizer comprises glycerol and polyhydric alcohol.Glycerol viscosity is low, is easily uniformly dispersed.Glycerol can all have the good compatibility with many colloidal materials.Glycerol is as plasticizer, even if diffusion admittance is blocked by some solid particles, or filled liquid viscosity is increased, glycerol is still enough to ethanol is spread wherein.Conventional polyhydric alcohol is as xylitol, sorbitol, hydrogenated corn syrup etc.Polyhydric alcohol replaces glycerol to make plasticizer, and the migration of ethanol can obviously be suppressed.Reason is glycerol and ethanol energy complete miscibility, and these polyhydric alcohol slightly soluble in ethanol.Its oxygen penetration power of softgel shell taking glycerol as plasticizer is strong.Select sorbitol to do penetration power that plasticizer can reduce oxygen, thus prevent softgel shell too fast aging; But sorbitol can increase softgel shell hardness and dissolution time thereof, therefore glycerol and sorbitol should be used in combination.Glycerol and sorbitol share the mutual migration that farthest can reduce softgel shell and content component in gelatin soft capsule.
D) character of alginate jelly
Alginate jelly has another name called Algin, sodium alginate, Sodium Alginate, Sodium Alginate, sodium alginate, seaweed gel etc., and alginate jelly is a kind of natural polysaccharide, extracts from natural seaweed, has the stability needed for pharmaceutical preparation adjuvant, dissolubility, viscosity and safety.It has concentrated solution, forms the ability of gel and film forming.Alginate jelly is water-soluble, is insoluble to the organic solvents such as ethanol, ether, chloroform.Water-soluble one-tenth viscous liquid, 1% pH value of water solution is 6-8.Viscosity stabilized as pH=6-9, when being heated to more than 80 DEG C, then viscosity reduces.The sol-gel process of its gentleness, good biocompatibility make alginate jelly be suitable for as release or the capsule of embedding medicinal, albumen and cell.Alginate jelly has hygroscopicity, and during balance, the number of contained humidity depends on relative humidity.Dry alginate jelly in the container of good seal in 25 DEG C and following temperature storage quite stable.
A kind of safe food additive is not only by alginate jelly, and can be used as the base material of remedy diet, because it is actually a kind of native cellulose, the absorption of fat sugar and cholate can be slowed down, have reduce serum cholesterol, the effect of triglyceride and blood glucose in blood, can the modern disease such as prophylaxis of hypertension, diabetes, obesity.It can suppress poisonous metal as the accumulation in vivo such as strontium, cadmium, lead in intestinal, exactly because these important function of sodium alginate, is at home and abroad day by day valued by the people.
For increasing blood volume with maintain blood pressure, get rid of the whole body such as the histamine toxoid that produces and wound is lost blood, the stablizing of perioperatively blood circulation, bleeding profusely property shock, burn shock, hyperpyrexia and acute dysentery of burning and dewater, therapeutic effect is good.Also have and cholesterol is excreted, suppress Pb, Cd, Sr are absorbed by the body and protect gastrointestinal tract, whole intestinal, fat-reducing, hypoglycemic effect.Mainly on medicament be used as suspending agent, emulsifying agent, sticky dose, the capsule material etc. of microcapsule.Alginate jelly is used as the binding agent of tablet, and the amount put in prescription is depended in the impact of alginate jelly on tabletting properties, and in some cases, alginate jelly can promote the disintegrate of tablet.Alginate jelly can add in the process of granulating, and such manufacturing process is simpler.
E) character of hypromellose
Hydroxypropyl emthylcellulose, has another name called hypromellose, HPMC, and English name is called for short HPMC, is select the gossypin of high purity as raw material, obtains in the basic conditions through special etherificate, and outward appearance is white or off-white powder.Not containing any animal organ and oils and fats isoreactivity composition, be non-ionic celluloses ether, outward appearance is the powder of white, odorless tasteless.Safety non-toxic, can make food additive, empty calory, contacts non-stimulated to skin, mucosa.
Hydroxypropyl emthylcellulose water soluble, aqueous solution has surface activity, and transparency is high, stable performance.HPMC has hot gelling properties, forms gel and separates out, dissolve again after cooling after the heating of product water solution, and the product gelling temp of different size is different.Dissolubility changes with viscosity, and viscosity is lower, and dissolubility is larger.HPMC also has thickening capabilities, the low ashes of salt tolerance, pH stability, water-retaining property, dimensional stability, excellent film property and the feature such as resistance to enzymatic, dispersibility and caking property widely.
Beneficial effect of the present invention:
1, the present invention is by replacing to modified starch and carrageenan by the main component gelatin of conventional capsules capsule material, overcomes a lot of shortcomings of gelatin, and cross-linking reaction, storge quality difference etc. easily occur in moisture absorption as safe not, easy in animal origin.Modified starch has film performance, gas barrier, caking property etc., and security performance is high and have good elasticity, and rate of dissolution is better than gelatin.With the addition of the modified starch of carrageenan, improve film strength and speed, and reduce gelling temp and melting temperature.The soft capsule prepared by modified starch and carrageenan, character is comparatively stable, not easily crosslinking phenomena occurs, and does not have oxidation cross-linked problem with soft capsule prepared by gelatin substitution material, without the need to adding antioxidant.
2, sorbitol is added in this capsule material formula, the plasticizer that sorbitol is inherently good, there is good moistening effect, the moisture that soft capsule keeps certain can be made, can effectively prevent soft capsule dry, aging, improve the moisture retention of soft capsule, sorbitol also has the preparation that froth breaking effect is conducive to capsule material simultaneously.In conventional formulation, normal independent glycerol is as plasticizer, and glycerol consumption is large, and then softgel shell is softer, the easy moisture absorption, and pressurized is yielding, and drying time is long; The too little softgel shell of consumption is firmly crisp, causes the leakage of soft gelatin capsule later stage.As being used alone sorbitol, its plasticity is worse than glycerol, and sorbitol cost is higher than glycerol, and again because its Water-saving effect is good, soft gelatin capsule is not easily dry, and soft gelatin capsule surface there will be adhesion sensation.
Time used in combination, not only above problem can be avoided, well well material transport can also be controlled.Glycerol belongs to low alcohol, and molecular weight is lower, if be used alone, intermolecular gap is more, and oxygen can freely pass through, and increases the oxidized probability of content, and small-molecule substance such as hydrone also can freely pass through, and material produces migration, causes loading amount problem.Sorbitol belongs to polyhydric alcohol, and molecular weight is comparatively large, used in combination, not only reduces intermolecular gap, prevents the generation of oxygen reaction and material transport.And drying time also shortens, add soft gelatin capsule plasticity, ensure product quality.
3, capsule material formula adds thickening agent alginate jelly, hypromellose improves gelatin viscosity, suitably can improve flexibility and the elasticity of soft capsule, make it dissolve in gastrointestinal presumptive area, release content, and the rapid disintegrate of capsule, good stability, water content can be made low.
Feature of the present invention and advantage will be described in detail by embodiment.
[detailed description of the invention]
The formula of a kind of non-soft-gelatin softgel shell of the present invention, comprise modified starch, carrageenan, plasticizer, water, thickening agent, the percentage by weight of described each component is:
Modified starch 25 ~ 75%;
Carrageenan 10 ~ 30%;
Plasticizer 10 ~ 25%;
Water 40 ~ 50%;
Thickening agent 2 ~ 12%;
The pigment that the color of soft capsule soft gelatin capsule is as required added.
Described modified starch is PURE COTE PURE COTE B790, and carrageenan is the mixture of kappa-carrageenan and ι-carrageenan, and the ratio of kappa-carrageenan and ι-carrageenan is 1:1.Described plasticizer is glycerol and sorbitol, and the ratio of glycerol and sorbitol is 0.4 ~ 0.6:0.4 ~ 0.7.Described thickening agent is alginate jelly and hypromellose, and the ratio of sodium alginate and hypromellose is 8.5 ~ 11.5:0.005 ~ 0.015.The purified water that the water of described use is distillation equipment, prepared by ion-exchange unit or reverse osmosis equipment.Described pigment determines the color of capsule, kind and the consumption of pigment are determined by capsule color, such as 1000 blue capsules need light blue 0.132g, whole red capsule needs carmine 0.128g, white portion does not use pigment and uses titanium dioxide mother solution, and all-transparent capsule does not then add pigment and titanium dioxide mother solution.
Embodiment:
First drop in glue pot by purified water 40kg, glycerol 22kg and sorbitol 18kg, close dog-house, stir, mixeding liquid temperature is risen to 60 DEG C, whole sol-process ensures that intermediate water temperature is at 60 DEG C ~ 80 DEG C.
Then stir while add PURE COTE PURE COTE B790 50kg, kappa-carrageenan 10kg, ι-carrageenan 10kg, alginate jelly 8kg, hypromellose 0.1kg to glue pot, control input speed and prevent conglomeration, carry out colloidal sol under vacuumized conditions, dissolution time is 1 hour.
Again by pigment 0.3kg with dropping in glue after hot water dissolving, opacifier titanium dioxide is made into mother solution and drops in glue, stirs.
Sampling detect gelatin viscosity, moisture, when viscosity number 18000pa.s moisture is 36.8% close gas outlet, locking dog-house, in glue pot, pass into compressed air, put Jiao Kou place bind more than 120 orders filter bag filter glue.Glue is put into the glue-storing barrel be incubated in advance at 60 DEG C, glue carries out pelleting compacting with Soft Capsule Machinery after 60 DEG C of insulation froth breakings leave standstill 4 hours.
The present invention, by the main component gelatin of conventional capsules capsule material is replaced to modified starch and carrageenan, overcomes a lot of shortcomings of gelatin, and cross-linking reaction, storge quality difference etc. easily occur in moisture absorption as safe not, easy in animal origin.Modified starch has film performance, gas barrier, caking property etc., and security performance is high and have good elasticity, and rate of dissolution is better than gelatin.With the addition of the modified starch of carrageenan, improve film strength and speed, and reduce gelling temp and melting temperature.The soft capsule prepared by modified starch and carrageenan, character is comparatively stable, not easily crosslinking phenomena occurs, and does not have oxidation cross-linked problem with soft capsule prepared by gelatin substitution material, without the need to adding antioxidant.
Sorbitol is added in this capsule material formula, the plasticizer that sorbitol is inherently good, there is good moistening effect, the moisture that soft capsule keeps certain can be made, can effectively prevent soft capsule dry, aging, improve the moisture retention of soft capsule, sorbitol also has the preparation that froth breaking effect is conducive to capsule material simultaneously.In conventional formulation, normal independent glycerol is as plasticizer, and glycerol consumption is large, and then softgel shell is softer, the easy moisture absorption, and pressurized is yielding, and drying time is long; The too little softgel shell of consumption is firmly crisp, causes the leakage of soft gelatin capsule later stage.As being used alone sorbitol, its plasticity is worse than glycerol, and sorbitol cost is higher than glycerol, and again because its Water-saving effect is good, soft gelatin capsule is not easily dry, and soft gelatin capsule surface there will be adhesion sensation.
Time used in combination, not only above problem can be avoided, well well material transport can also be controlled.Glycerol belongs to low alcohol, and molecular weight is lower, if be used alone, intermolecular gap is more, and oxygen can freely pass through, and increases the oxidized probability of content, and small-molecule substance such as hydrone also can freely pass through, and material produces migration, causes loading amount problem.Sorbitol belongs to polyhydric alcohol, and molecular weight is comparatively large, used in combination, not only reduces intermolecular gap, prevents the generation of oxygen reaction and material transport.And drying time also shortens, add soft gelatin capsule plasticity, ensure product quality.
Capsule material formula adds thickening agent alginate jelly, hypromellose improves gelatin viscosity, suitably can improve flexibility and the elasticity of soft capsule, makes it dissolve in gastrointestinal presumptive area, release content, and the rapid disintegrate of capsule, good stability, water content can be made low.
Above-described embodiment is to explanation of the present invention, is not limitation of the invention, anyly all belongs to protection scope of the present invention to the scheme after simple transformation of the present invention.
Claims (6)
1. a formula for non-soft-gelatin softgel shell, comprises modified starch, carrageenan, plasticizer, water, thickening agent,
The percentage by weight of described each component is:
Modified starch 25 ~ 75%;
Carrageenan 10 ~ 30%;
Plasticizer 10 ~ 25%;
Water 40 ~ 50%;
Thickening agent 2 ~ 12%;
The pigment that the color of soft capsule soft gelatin capsule is as required added.
2. the formula of a kind of non-soft-gelatin softgel shell as claimed in claim 1, it is characterized in that: described modified starch is PURE COTE PURE COTE B790, carrageenan is the mixture of kappa-carrageenan and ι-carrageenan, and the ratio of kappa-carrageenan and ι-carrageenan is 1:1.
3. the formula of a kind of non-soft-gelatin softgel shell as claimed in claim 1, is characterized in that: described plasticizer is glycerol and sorbitol, and the ratio of glycerol and sorbitol is 0.4 ~ 0.6:0.4 ~ 0.7.
4. the formula of a kind of non-soft-gelatin softgel shell as claimed in claim 1, is characterized in that: described thickening agent is alginate jelly and hypromellose, and the ratio of sodium alginate and hypromellose is 8.5 ~ 11.5:0.005 ~ 0.015.
5. the formula of a kind of non-soft-gelatin softgel shell as claimed in claim 1, is characterized in that: the purified water that the water of described use is distillation equipment, prepared by ion-exchange unit or reverse osmosis equipment.
6. the formula of a kind of non-soft-gelatin softgel shell according to any one of claim 1 to 5, it is characterized in that: described pigment determines the color of capsule, kind and the consumption of pigment are determined by capsule color, such as 1000 blue capsules need light blue 0.132g, whole red capsule needs carmine 0.128g, white portion does not use pigment and uses titanium dioxide mother solution, and all-transparent capsule does not then add pigment and titanium dioxide mother solution.
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| CN112336698A (en) * | 2019-08-09 | 2021-02-09 | 南京科宁检测科技有限公司 | Rapidly disintegrating vaginal soft capsule composition and preparation method thereof |
| CN112294775A (en) * | 2020-12-10 | 2021-02-02 | 浙江艾兰得生物科技有限公司 | Plant-based soft capsule rubber with anti-adhesion function |
| CN113712935A (en) * | 2021-09-13 | 2021-11-30 | 陕西中医药大学 | Modified vegetable gelatin soft capsule shell and preparation method thereof |
| CN113712935B (en) * | 2021-09-13 | 2023-11-17 | 陕西百瑞维力生物科技有限公司 | Modified vegetable gum soft capsule shell and preparation method thereof |
| CN115364068A (en) * | 2022-08-23 | 2022-11-22 | 青岛至纯生物科技有限公司 | Temperature-sensitive capsule and preparation method thereof |
| CN116196289A (en) * | 2023-03-09 | 2023-06-02 | 上海荃吉康医药科技有限公司 | Medical capsule composite adhesive and raw material proportion and preparation method thereof |
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Application publication date: 20150211 |