CN104324523B - Complete thread formula sampling chromatographic column - Google Patents
Complete thread formula sampling chromatographic column Download PDFInfo
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- CN104324523B CN104324523B CN201410706410.8A CN201410706410A CN104324523B CN 104324523 B CN104324523 B CN 104324523B CN 201410706410 A CN201410706410 A CN 201410706410A CN 104324523 B CN104324523 B CN 104324523B
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Abstract
The invention discloses a kind of complete thread formula sampling chromatographic column, comprise sample cup, cylinder, filter and bottom valve, the bottom of cylinder is dismountable is provided with lower cover, under be covered with step supporting filter plate, lower cover and bottom valve are closed integrative-structure; When the lower cover unloaded bottom lower prop and bottom valve, go out sample cup and can utilize the dismountable bottom being arranged on cylinder of the complete thread cooperatively interacted with cylinder; Column body is provided with piston, and piston is provided with mesopore and flexible upper and lower lips, upper and lower lips external diameter is micro-be greater than post interior diameter, with the micro-tight fit of column wall; The magnetic control ball valve that T-shaped stainless steel wire connects spheroid and asymmetric magnetic material composition is also positioned at post.Structure of the present invention simply can, by ingenious arrange dismountable go out sample cup, achieve the convenient, fast and accurate taking-up of target filler in pillar, for increasing work efficiency, reducing operating procedure, reduce solvent consumption and concentrated energy consumption all significant, have a extensive future.
Description
Technical field
The present invention relates to a kind of chromatographic column, specifically refer to complete thread formula sampling chromatographic column.
Background technology
Chromatographic column is widely used in column chromatography operation, is requisite laboratory apparatus in chemical analysis, separation, is also widely used in industrial production.Chromatographic column can load the multiple fillers such as silica gel, glucan and polyamide, is widely used in that natural products is purified, the analysis, separation etc. of protein purification and some artificial-synthetic compounds.
When carrying out column chromatography operation, first target components is launched in pillar, according to the affine degree of target components and filler and solvent, target components is positioned in the diverse location in pillar, realize initial gross separation, then adopt eluant, eluent by target components one by one wash-out out, the separation completely of realize target component.
But need a large amount of eluant, eluents when employing eluant, eluent carries out wash-out, eluting agent is often up to tens bed volumes, and the enriching service that the consumption of organic solvent is very large and follow-up is also very loaded down with trivial details.If can by the convenient, fast and accurate taking-up of part filler of adsorbed target component in pillar, then carry out extracting directly with suitable solvent and obtain target components, can not only increase work efficiency, reduce operating procedure, effectively can also reduce the consumption of organic solvent and the concentrated required energy, there is the energy-saving and emission-reduction meaning of highly significant.
But, existing chromatographic column does not all well address this problem, chromatographic column conventional at present adopts glass to make mostly, bottom is provided with sieve plate and valve, sieve plate and valve all can not be dismantled, cannot realize filler convenient, fast, accurately take out, thus prior art can not meet the requirement of people.
Summary of the invention
The technical problem to be solved in the present invention is exactly the deficiency existed for prior art, a kind of complete thread formula is provided to sample chromatographic column, can by the convenient, fast and accurate taking-up of the filler of any part in pillar, for follow-up separation and purification work provides very big convenience.
For overcoming the deficiencies in the prior art, the present invention takes following technical scheme:
A kind of complete thread formula sampling chromatographic column, comprises sample cup, cylinder, filter and bottom valve, it is characterized in that: the bottom of cylinder is dismountable is provided with lower cover, under be covered with step supporting filter plate, lower cover and bottom valve are closed integrative-structure; Cylinder outer wall and go out sample cup inwall and be provided with the complete thread cooperatively interacted, when the lower cover unloaded bottom lower prop and bottom valve, goes out sample cup and can utilize the dismountable bottom being arranged on cylinder of the complete thread cooperatively interacted.
Described lower cover and cylinder adopt trapezoidal thread to coordinate, and have packing ring to realize dismountable being tightly connected in lid.
Described column body is provided with piston, and piston is provided with mesopore and flexible upper and lower lips, upper and lower lips external diameter is micro-be greater than post interior diameter, with the micro-tight fit of column wall; The connection of T-shaped stainless steel wire coordinates the spheroid of mesopore size and asymmetric magnetic material composition magnetic control ball valve to be also positioned at post.
Described cylinder upper end is dismountable is provided with upper cover, above covers and arranges air valve, solvent valve and service valve, be convenient to combined operation.
Described upper cover and cylinder upper end adopt trapezoidal thread to coordinate, and have packing ring to realize dismountable being tightly connected in lid.
Chromatographic column generally adopts transparent glass or organic material to make, the design adopts trapezoidal thread to coordinate upper cover and lower cover at chromatographic column upper and lower side, packing ring is had to realize the sealing of screw thread compression in lid, on cover air valve be set, solvent valve, service valve is convenient to combined operation, when needing to take out the target filler in pillar, first the lower cover bottom cylinder and bottom valve are replaced to out sample cup, access compressed air control filler more descending, filler in pillar is urged to out downwards in sample cup, if the filler now in sampling cup is not target filler, then can the filler of taking-up be inserted in pillar again or discard, until take out target filler.
Piston has mesopore and the upper and lower lips of elasticity, upper and lower lips external diameter is micro-be greater than post interior diameter can tight fit micro-with column wall, be convenient to upper labial plate pressurized when upper piston area has an air pressure and be adjacent to column wall, realize positiver sealing, descent of piston can pass through labial plate scraping column wall; T-shaped stainless steel wire connects spheroid and symmetrical magnetic material composition magnetic control ball valve, magnet symmetry attracts magnetic material, moving up and down magnet can drive control spheroid to realize the open and close of piston hole, and after spheroid removes piston hole, solvent, air just can pass piston hole; Lower cover bottom cylinder and bottom valve are also replaced to out sample cup by spheroid closure piston hole, top compression air just can driven plunger move downward, filler in pillar is urged to out downwards in sample cup, if the filler now in sampling cup is not target filler, then can the filler of taking-up be inserted in pillar again or discard, until take out target filler.
Post lower thread and top are both trapezoidal thread, when needs go out sample, go out sample cup be upwards spun on screw thread appropriate location rotate just can hang up, moving magnet drives and controls spheroid closure piston hole, remove magnet again, control to open compressed air valve, promote filler downwards with compressed air-driven piston and enter out sample cup, adjust sample cup just can adjust sample cup sampling amount in the position of screw thread.Closes compression air valve, just desirable after opening service valve pressure release to remove out sample wine material stand-by.
Compared with prior art, beneficial effect of the present invention is:
Simple and reliable for structure, ingenious arrange dismountable go out sample cup, utilize compressed air to carry out sample, the conveniently taking-up of realize target filler; Go out sample cup and not only can take out target filler, again can also be packed into new filler (clamp-oning from the bottom up during filling material), realize separating for several times and sampling; During sampling with naked eyes, uviol lamp or other intuitively detection method for foundation, instant detection can be realized, immediately sample.
Go out sample cup to coordinate with the complete thread of cylinder and be convenient to regulate sampling amount, and be connected firmly, can not drop.
Open and close piston because magnetic force controls ball valve indirectly, after pillar filling material, gas or solvent can be passed into, to enrich good filler being beneficial to separation; In separation process, hole can be blocked with spheroid when changing desolventizing, prevent solvent from breaking up filling surface to ensure separating effect; In separation process, in not emptying post internal solvent situation, target filler can be released cylinder when finding object, during promotion, block hole with ball, promote filler by air pressure descending; If do not have piston, so solvent can first be run out of from filler gap, could release filler after solvent drains, and when releasing, filler may dry up powdering, and non-targeted filler may be caused to fall down.
Present invention achieves the convenient, fast and accurate taking-up of target filler in pillar, for increasing work efficiency, reducing operating procedure, reduce organic solvent consumption and concentrate required energy consumption all significant, have a extensive future.
Accompanying drawing explanation
Fig. 1 is planar structure schematic diagram of the present invention.
Fig. 2 is outward appearance operating structure schematic diagram of the present invention.
Fig. 3 be of the present invention go out spline structure schematic diagram.
Fig. 4 is ball valve control structure schematic diagram of the present invention.
Fig. 5 is ball valve control principle schematic diagram of the present invention.
In figure, each label represents:
1, upper cover; 2, sealing gasket; 3, threaded engagement; 4, magnetic material; 5, spheroid; 6, magnet; 7, upper labial plate; 8, labial plate; 9, piston hole; 10 piston bodies; 11, cylinder; 12, lower cover; 13, filter; 14, filter step; 15, complete thread; 16, sample cup is gone out; 21, compressed air valve; 22, solvent valve; 23, service valve; 24, bottom valve.
Detailed description of the invention
Now by reference to the accompanying drawings, the present invention is illustrated further.
As shown in Figure 1, Figure 2, the formula of complete thread shown in Fig. 3, Fig. 4 and Fig. 5 sampling chromatographic column, comprise sample cup 16, cylinder 11, filter 13 and bottom valve 24, the bottom of cylinder is dismountable is provided with lower cover 12, and lower cover 12 is provided with step 14 supporting filter plate 13, and lower cover 12 and bottom valve 24 are for closing integrative-structure; Cylinder outer wall and go out sample cup inwall and be provided with the complete thread cooperatively interacted, when the lower cover 12 unloaded bottom lower prop and bottom valve 24, goes out sample cup and can utilize the dismountable bottom being arranged on cylinder of the complete thread cooperatively interacted.
Described lower cover 24 adopts trapezoidal thread to coordinate with cylinder 12, has packing ring 2 to realize dismountable being tightly connected in lid.
Described cylinder 11 inside is provided with piston 10, and piston 10 is provided with mesopore 9 and flexible upper and lower lips 7,8, upper and lower lips 7,8 external diameter is micro-be greater than post interior diameter, with the micro-tight fit of column wall; The spheroid 5 of T-shaped stainless steel wire connection mesopore size and asymmetric magnetic material 4 form magnetic control ball valve and are also positioned at post.
Described cylinder 11 upper end is dismountable is provided with upper cover 1, above covers and arranges air valve 21, solvent valve 22 and service valve 23, be convenient to combined operation.
Described upper cover 1 and cylinder upper end adopt trapezoidal thread to coordinate, and have packing ring 2 to realize dismountable being tightly connected in lid.
Chromatographic column generally adopts transparent glass or organic material to make, the design adopts trapezoidal thread to coordinate upper cover 1 and lower cover 12 at chromatographic column upper and lower side, packing ring 2 is had to realize the sealing of screw thread compression in lid, upper cover 1 is arranged air valve 21, solvent valve 22, service valve 23 is convenient to combined operation, when needing to take out the target filler in pillar, first the lower cover 12 bottom cylinder and bottom valve 24 are replaced to out sample cup 16, access again access again compressed air control filler descending, filler in pillar is urged to out downwards in sample cup 16, if the filler now in sampling cup 16 is not target filler, then can the filler of taking-up be inserted in pillar again or discard, until take out target filler.
Piston 10 has mesopore 9 and the upper and lower lips 7,8 of elasticity, upper and lower lips 7,8 external diameter is micro-be greater than post interior diameter can tight fit micro-with column wall, be convenient to upper labial plate pressurized when upper piston area has an air pressure and be adjacent to column wall, realize positiver sealing, piston 10 is descending can pass through labial plate scraping column wall; T-shaped stainless steel wire connects spheroid 5 and symmetrical magnetic material 4 forms magnetic control ball valve, magnet 6 symmetry attracts magnetic material, move up and down magnet 6 can drive and control spheroid and realize the open and close of piston hole 9, spheroid 5 to remove after piston hole 9, and solvent, air just can pass piston hole 9; Lower cover 12 bottom cylinder and bottom valve 24 are also replaced to out sample cup 16 by spheroid 5 closure piston hole 9, top compression air just can driven plunger 10 move downward, filler in pillar is urged to out downwards in sample cup 16, if the filler now in sampling cup 16 is not target filler, then can the filler of taking-up be inserted in pillar again or discard, until take out target filler.
Post lower thread and top are both trapezoidal thread, when needs go out sample, go out sample cup 16 be upwards spun on screw thread 15 appropriate location rotate just can hang up, moving magnet 6 drives and controls spheroid 5 closure piston hole 9, remove magnet 6 again, control to open compressed air valve 21, promote filler downwards with compressed air-driven piston 10 and enter out sample cup 16, adjust sample cup just can adjust sample cup sampling amount in the position of screw thread.Closes compression air valve 21, just desirable after opening service valve 23 pressure release to remove out sample wine material stand-by.
Above-mentioned just preferred embodiment of the present invention, not does any pro forma restriction to the present invention.Any those of ordinary skill in the art, when not departing from technical solution of the present invention scope, can utilize the technology contents of above-mentioned announcement to make many possible variations and modification to technical solution of the present invention, or being revised as the Equivalent embodiments of equivalent variations.Therefore, every content not departing from technical solution of the present invention, according to the technology of the present invention essence to any simple modification made for any of the above embodiments, equivalent variations and modification, all should drop in the scope of technical solution of the present invention protection.
Claims (4)
1. a complete thread formula sampling chromatographic column, comprises sample cup, cylinder, filter and bottom valve, it is characterized in that: the bottom of cylinder is dismountable is provided with lower cover, under be covered with step supporting filter plate, lower cover and bottom valve are closed integrative-structure; Cylinder outer wall and go out sample cup inwall and be provided with the complete thread cooperatively interacted, when the lower cover unloaded bottom lower prop and bottom valve, goes out sample cup and can utilize the dismountable bottom being arranged on cylinder of the complete thread cooperatively interacted; Described column body is provided with piston, and piston is provided with mesopore and flexible upper and lower lips, upper and lower lips external diameter is micro-be greater than post interior diameter, with the micro-tight fit of column wall; The connection of T-shaped stainless steel wire coordinates the spheroid of mesopore size and asymmetric magnetic material composition magnetic control ball valve to be also positioned at post.
2. complete thread formula sampling chromatographic column according to claim 1, is characterized in that: described lower cover and cylinder adopt trapezoidal thread to coordinate, has packing ring to realize dismountable being tightly connected in lid.
3. complete thread formula sampling chromatographic column according to claim 1 and 2, is characterized in that: described cylinder upper end is dismountable is provided with upper cover, above covers and arranges air valve, solvent valve and service valve, be convenient to combined operation.
4. complete thread formula sampling chromatographic column according to claim 3, is characterized in that: described upper cover and cylinder upper end adopt trapezoidal thread to coordinate, and have packing ring to realize dismountable being tightly connected in lid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410706410.8A CN104324523B (en) | 2014-12-01 | 2014-12-01 | Complete thread formula sampling chromatographic column |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410706410.8A CN104324523B (en) | 2014-12-01 | 2014-12-01 | Complete thread formula sampling chromatographic column |
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| CN104324523A CN104324523A (en) | 2015-02-04 |
| CN104324523B true CN104324523B (en) | 2015-10-07 |
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| CN105004806B (en) * | 2015-07-08 | 2017-04-05 | 浙江省海洋水产研究所 | Concertina type spiral combination type immune affinity column |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN2102789U (en) * | 1991-04-26 | 1992-04-29 | 西安医科大学 | Combined dry-pillar layer pillar |
| EP2652492A1 (en) * | 2010-12-16 | 2013-10-23 | Marcellus Johannes Hubertus Raedts | Disposable horizontal or radial flow type chromatographic column |
| CN202289557U (en) * | 2011-10-24 | 2012-07-04 | 利穗科技(苏州)有限公司 | Rapid and dynamic compression chromatography column |
| CN202700138U (en) * | 2012-06-19 | 2013-01-30 | 石家庄诚志永华显示材料有限公司 | Split-type chromatographic column device |
| CN204275568U (en) * | 2014-12-01 | 2015-04-22 | 吉首大学 | Complete thread formula sampling chromatographic column |
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Effective date of registration: 20170516 Address after: 226200, Jiangsu Province, Nantong City, Qidong City North Pole village five sets Patentee after: Qidong Fuzhou vegetable and fruit professional cooperatives Address before: 416000 Hunan, Xiangxi Tujia and Miao Autonomous Prefecture, Jishou City People's road, No. 120 Patentee before: Jishou University |