CN104324250B - A kind of cerebral arterial thrombosis Chinese medicine composition and preparation method thereof - Google Patents
A kind of cerebral arterial thrombosis Chinese medicine composition and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/646—Arachnids, e.g. spiders, scorpions, ticks or mites
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
Abstract
The invention discloses a kind of cerebral arterial thrombosis Chinese medicine compositions and preparation method thereof.Chinese medicine composition includes following parts by weight Chinese medicine material drug：100 150 parts of Radix Notoginseng, 170 250 parts of leech, 30 50 parts of Radix Astragali, 5 10 parts of borneol, 15 25 parts of lotus nut, 15 25g of the stem of noble dendrobium, 35 50 parts of Rhizoma Gastrodiae, 35 parts of scorpio, 15 25 parts of ground bettle.Preparation method is：Radix Notoginseng, leech, Radix Astragali, lotus nut, the stem of noble dendrobium, Rhizoma Gastrodiae, scorpio and ground bettle are respectively crushed into fine powder, are sieved, ratio weighs and is mixed into mixed powder by weight；Borneol is added to mixing in ethyl alcohol again, uniformly spray into mixed powder in, sealing it is bored for 24 hours to get.Chinese medicine composition of the present invention can be made into common oral Pharmaceutical dosage forms, such as capsule, tablet, granule, pill with pharmaceutically acceptable together with carrier and excipient.Medicine composite for curing cerebral arterial thrombosis significant effect of the present invention.
Description
Technical field
The invention belongs to Chinese medicine composition, a kind of cerebral arterial thrombosis Chinese medicine composition and its preparation side are specifically disclosed
Method.
Background technology
Cerebral arterial thrombosis is also known as apoplexy, is the common refractory disease for seriously endangering human health and life security,
Motherland's medicine is classified as first of " wind, consumptive disease, distension, diaphragm " four big difficult disease, there is it is apparent three high (incidence is high, disability rate is high,
The death rate is high) phenomenon.According to the annual patient that cerebral arterial thrombosis occurs of statistics China up to 2,000,000, incidence is up to 120/10
Ten thousand；Since the patient of cerebral arterial thrombosis death is up to 1,200,000, existing survival patient 7,000,000, wherein 4,500,000 patients lose in various degree
It loses labour and can't take care of oneself, disability rate is up to 75%.Cerebral arterial thrombosis causes very big prestige to human health and life
The side of body, not only brings considerable distress to patient, returns patient home and bring great financial burden.Therefore, it is serious to fully realize it
Property, its treatment and prevention level are improved, it is the task of top priority to reduce its incidence, disability rate and the death rate.
At present treatment cerebral arterial thrombosis Western medicine it is very much, have vasodilator agent, expanding blood volume drug, thrombolytic drug,
Anticoagulant, calcium ion antagonist etc., these drugs use extensively, but have and cause intracerebral steal syndrome, bleeding etc. bad anti-
The danger answered.
Invention content
For problems of the prior art, the purpose of the present invention is to provide a kind of cerebral arterial thrombosis Chinese medicine groups
Close object and preparation method thereof.The pharmaceutical composition drug effect of the present invention is gentle, and prescription is simple, and clear mechanism, toxic side effect is small, has
Qi and activate blood circulation, clearing and activating the channels and collaterals, the effect of removing blood stasis for promoting tissue regeneration, consciousness regaining, for treating cerebral arterial thrombosis significant effect.
In order to achieve the above object, the present invention is realized using following technical scheme.
A kind of cerebral arterial thrombosis Chinese medicine composition, which is characterized in that including following parts by weight traditional Chinese medicinal components：Radix Notoginseng
100-150 parts, 170-250 parts of leech, 30-50 parts of Radix Astragali, 5-10 parts of borneol, 15-25 parts of lotus nut, stem of noble dendrobium 15-25g, Rhizoma Gastrodiae
35-50 parts, 3-5 parts of scorpio, 15-25 parts of ground bettle.
Preferably, the traditional Chinese medicinal components dosage is：130-138 parts of Radix Notoginseng, 188-230 parts of leech, 37-45 parts of Radix Astragali, ice
7-9 parts of piece, 19-23 parts of lotus nut, stem of noble dendrobium 19-23g, 37-45 parts of Rhizoma Gastrodiae, 3-5 parts of scorpio, 19-23 parts of ground bettle.
Preferably, the traditional Chinese medicinal components optimum amount is：125 parts of Radix Notoginseng, 208 parts of leech, 41.2 parts of Radix Astragali, borneol 8.3
Part, 20.8 parts of lotus nut, 20.8 parts of the stem of noble dendrobium, 41.2 parts of Rhizoma Gastrodiae, 4.2 parts of scorpio, 20.8 parts of ground bettle.
The preparation method of above-mentioned cerebral arterial thrombosis Chinese medicine composition, which is characterized in that include the following steps：By three
Seven, leech, Radix Astragali, lotus nut, the stem of noble dendrobium, Rhizoma Gastrodiae, scorpio and ground bettle are respectively crushed into fine powder, sieve with 100 mesh sieve, by weight
Example weighs and is mixed into mixed powder；Borneol is added to mixing in 8-10 parts of ethyl alcohol, is uniformly sprayed into mixed powder, sealing is bored
For 24 hours to get.
Above-mentioned cerebral arterial thrombosis Chinese medicine composition can be into one together with pharmaceutically acceptable carrier and excipient
Common oral Pharmaceutical dosage forms well known in the art are made in step, such as capsule, tablet, granule, pill or oral solution.
Compared with prior art, the present invention has the following advantages and beneficial effects.
The etiology and pathogenesis that apoplexy occurs is mostly positive unsaturated vapor, cold obstruction causing qi stagnation, the resistance of blood stasis arteries and veins.In its formation and development process
In, it first then causes void in fact mostly, also there is first empty then cause reality person to treat suitable actual situation based on simulataneous insufficiency and excessive and take into account, sample is simultaneous
It controls；Suitable qi and activate blood circulation, clearing and activating the channels and collaterals, inducing resuscitation.
The Chinese medicine composition of the present invention has selected Radix Notoginseng, leech, Radix Astragali, borneol, lotus nut, the stem of noble dendrobium, Rhizoma Gastrodiae, scorpio and soil
Soft-shelled turtle worm is combined.This composition is reinforced vital energy with Radix Astragali, agitates healthy tendency, using promoting circulation of blood arteries and veins as main ingredient；《Japan hanako materia medica》, it is believed that
Radix Astragali can help gas to strengthen the bone, and put on flesh and enrich blood.Leech, scorpio, ground bettle, Radix Notoginseng blood-breaking, by the stasis of blood, dredging collateral, analgesic, treatment stasis blocking is not
Supplemented by logical；《Book on Chinese herbal medicine is recorded through hundred kinds》Record " blood of ordinary person's body hemostasis sheet resistance, still Animando person easily control ... leech most eating people,
Controlling of accumulating in the course of time is attacked by means of its power ",《Kaibao Bencao》Recording full worm " can treat all urticarias and apoplexy and hemiplegia, facial paralysis, language
It is puckery, spasm of hands and feet ",《King's pond medicine solution》Think Radix Notoginseng can " and battalion hemostasis, the row stasis of blood of promoting blood circulation, row hemostasis and hold back new blood ".Rhizoma Gastrodiae, borneol
Match, soothing the liver relieves dizziness, high fever, infantile convulsions, epilepsy, etc., calms the frightened, having one's ideas straightened out for adjutant；《Collected statements on the herbal foundation》Record Rhizoma Gastrodiae " it is anxious to cure mainly intermittent headache, headache ... four limbs contraction,
Language has some setbacks, all apoplexy ", " borneol controls aphasia from apoplexy, leads to all keys ".The stem of noble dendrobium, two pharmacological property of lotus nut are partially cold and cool, above-mentioned all to control
Medicine warm is too to make.The above all medicines share plays qi and activate blood circulation, clearing and activating the channels and collaterals, removing blood stasis for promoting tissue regeneration, consciousness regaining altogether.
Modern pharmacological research confirms that Radix Astragali has the function of that directly expanding blood vessel plays reduction of blood pressure in high-speed, and is lacked with anti-
Oxygen acts on, antagonism of the heart and brain tissues to anoxic when can improve cerebral infarction, heart infarction generation；Leech, ground bettle, scorpio can be expanded
Blood vessel hinders blood clotting, prevents embolus from being formed；Radix Notoginseng energy expansion of coronary artery and antihypertensive effect；Rhizoma Gastrodiae can increase the heart
Myotrophy blood flow improves myocardial circulation, increases myocardial oxygen delivery, has protective effect to myocardial anoxia.These Chinese traditional medicine compositions make
It obtains each efficacy of drugs and generates synergistic effect, so as to effectively treat cerebral arterial thrombosis.
The present invention Chinese medicine composition drug effect it is gentle, prescription is simple, and clear mechanism, toxic side effect is small, have qi and activate blood circulation,
Clearing and activating the channels and collaterals, the effect of removing blood stasis for promoting tissue regeneration, consciousness regaining, for treating cerebral arterial thrombosis significant effect.
Specific implementation mode
Five typical specific embodiments of the present invention are given below, but the invention is not limited in these embodiments.
Embodiment 1：
For a kind of cerebral arterial thrombosis Chinese medicine composition of the present invention, dosage form is capsule, specific Chinese medicinal component and system
Preparation Method is as follows：
(1) material medicine is weighed respectively：102g Radix Notoginseng, 175g leech, 33g Radix Astragalis, 7g borneols, 15g lotus nuts, 15g stones
Dry measure used in former times, 35g Rhizoma Gastrodiaes, 3g scorpios, 15g ground bettles.
(2) Radix Notoginseng, leech, Radix Astragali, lotus nut, the stem of noble dendrobium, Rhizoma Gastrodiae, scorpio and ground bettle are respectively crushed into fine powder, cross 100
Mesh sieves, and ratio weighs and is mixed into mixed powder by weight；Borneol is added to mixing in 8mL ethyl alcohol, uniformly sprays into mixing
In medicinal powder, sealing is bored for 24 hours, the encapsulated capsule up to the present invention.
Embodiment 2：
For a kind of cerebral arterial thrombosis Chinese medicine composition of the present invention, dosage form is tablet, specific Chinese medicinal component and system
Preparation Method is as follows：
(1) material medicine is weighed respectively：125g Radix Notoginseng, 208g leech, 41.2g Radix Astragalis, 8.3g borneols, 20.8g lotus nuts,
The 20.8g stems of noble dendrobium, 41.2g Rhizoma Gastrodiaes, 4.2g scorpios, 20.8g ground bettles.
(2) Radix Notoginseng, leech, Radix Astragali, lotus nut, the stem of noble dendrobium, Rhizoma Gastrodiae, scorpio and ground bettle are respectively crushed into fine powder, cross 100
Mesh sieves, and ratio weighs and is mixed into mixed powder by weight；Borneol is added to mixing in 9mL ethyl alcohol, uniformly sprays into mixing
In medicinal powder, sealing is bored for 24 hours, makees wetting agent granulation with a concentration of 80% ethyl alcohol, and whole grain is dry, crosses 20 mesh sieve, and granulation is added hard
Fatty acid magnesium is always mixed, and tabletting, film coating are up to tablet of the invention.
Embodiment 3：
For the present invention a kind of cerebral arterial thrombosis Chinese medicine composition, dosage form is granule, specific Chinese medicinal component and
Preparation method is as follows：
(1) material medicine is weighed respectively：148g Radix Notoginseng, 250g leech, 50g Radix Astragalis, 9g borneols, 25g lotus nuts, 25g stones
Dry measure used in former times, 50g Rhizoma Gastrodiaes, 5g scorpios, 25g ground bettles；
(2) Radix Notoginseng, leech, Radix Astragali, lotus nut, the stem of noble dendrobium, Rhizoma Gastrodiae, scorpio and ground bettle are respectively crushed into fine powder, cross 100
Mesh sieves, and ratio weighs and is mixed into mixed powder by weight；Borneol is added to mixing in 10mL ethyl alcohol, uniformly sprays into mixing
In medicinal powder, sealing is bored for 24 hours, makees wetting agent granulation with a concentration of 80% ethyl alcohol, whole grain is dry, crosses 20 mesh sieve, and medicine is added in granulation
The granule of the present invention is made of starch excipient.
Embodiment 4：
For a kind of cerebral arterial thrombosis Chinese medicine composition of the present invention, dosage form is capsule, specific Chinese medicinal component and system
Preparation Method is as follows：
(1) material medicine is weighed respectively：138g Radix Notoginseng, 230g leech, 45g Radix Astragalis, 9g borneols, 23g lotus nuts, 23g stones
Dry measure used in former times, 45g Rhizoma Gastrodiaes, 5g scorpios, 23g ground bettles.
(2) Radix Notoginseng, leech, Radix Astragali, lotus nut, the stem of noble dendrobium, Rhizoma Gastrodiae, scorpio and ground bettle are respectively crushed into fine powder, cross 100
Mesh sieves, and ratio weighs and is mixed into mixed powder by weight；Borneol is added to mixing in 10mL ethyl alcohol, uniformly sprays into mixing
In medicinal powder, sealing is bored for 24 hours, the encapsulated capsule up to the present invention.
Embodiment 5：
For a kind of cerebral arterial thrombosis Chinese medicine composition of the present invention, dosage form is capsule, specific Chinese medicinal component and system
Preparation Method is as follows：
(1) material medicine is weighed respectively：130g Radix Notoginseng, 188g leech, 37g Radix Astragalis, 7g borneols, 19g lotus nuts, 19g stones
Dry measure used in former times, 37g Rhizoma Gastrodiaes, 3g scorpios, 19g ground bettles.
(2) Radix Notoginseng, leech, Radix Astragali, lotus nut, the stem of noble dendrobium, Rhizoma Gastrodiae, scorpio and ground bettle are respectively crushed into fine powder, cross 100
Mesh sieves, and ratio weighs and is mixed into mixed powder by weight；Borneol is added to mixing in 8mL ethyl alcohol, uniformly sprays into mixing
In medicinal powder, sealing is bored for 24 hours, the encapsulated capsule up to the present invention.
Carry out the advantageous effect of the present invention is further explained drug below by way of test example.
Test example：Therapeutic effect of the Chinese medicine composition of the present invention to ischemia/reperfusion in rats cerebrovascular disease
(1) MCAO modelings
Healthy Wistar rats 60 are taken, male and female dual-purpose, 180~220g of weight is (by The Fourth Military Medical University experimental animal
The heart provides, and produces quality certification number：Scxk (army) word the 2008-005th).Laboratory sub-cage rearing 1 week, is randomly divided into 6 groups, often
Group 10.Before surgery 100,000 U/ of penicillin is injected intraperitoneally only in 3 days in all experimental animals, 2 times a day.Operation consent prohibits rat
Food, water 12h make intraluminal middle cerebral artery occlusion in rats with line brush and block (MCAO) model.With 1% yellow Jackets according to 30mg/kg
Weight carries out intraperitoneal anesthesia, takes dorsal position to be fixed in aseptic superclean bench, preserved skin, with Iodophors partly sterilised.In neck
Median incision is about 2.5cm, and successively chorista is to expose right carotid, and head-end is dissociated in neck, moved outside neck
Arteries and veins.In neck, external carotid artery crotch ligation external carotid artery, arteria carotis communis is ligatured in proximal part, and in the preset knot in its distal end
Binding.Close internal carotid distal end with artery clamp folder, in neck, external carotid artery crotch at nearly heart side 3mm, with No. 5 syringe needles
Common carotid artery wall is punctured, the nylon wire of known length, a diameter of 0.20mm and heating one end at microspheroidal is inserted into；Loosen dynamic
While arteries and veins presss from both sides, touching nylon wire makes it enter cranium to arteria cerebri media (MCA) through internal carotid, loop length about 17~20mm,
The power that is hampered stops being inserted into, and arteria carotis communis is ligatured together together with nylon wire, removes artery clamp, layer-by-layer suture notch.Postoperative abdominal cavity
It injects 100,000 U/ of penicillin only, 2 times a day, for three days on end, prevents infection.Postoperative room temperature control is at 26~30 DEG C.
MCAO modeling evaluation criterions：Left side forelimb buckling, is unable to full extension；When carrying tail, left side forelimb grip weakens；It carries
When tail, turn-take to the left；It is non-directional when free movement, it turn-takes or topples over to the left；It spontaneous cannot walk, the loss of consciousness.
Such as there is one of above-mentioned symptom in rat after modeling, otherwise as modeling success is failure, is not included in experiment point
Group.
Neurological deficits score measures.Modeling animal carries out nervous function scoring, scoring side respectively for 24 hours after surgery
Method divides standards of grading processed with reference to the right side middle cerebral artery infarction model 5 of Bederson：0 point, impassivity functional impairment symptom；1
Point, left fore is unable to full extension；2 points, circulatory motion to the left, slight focal neurological missing；3 points, topple over to the left, in
Spend focal neurological missing；It 4 points, cannot walk naturally, level of consciousness inhibits, serious neurological afunction.
(2) test method
2-1 grouping administrations
After the successful rat of modeling is fed 15 days meticulously, survival rats are randomly divided into model group, control group, treatment height
Dosage group, treats middle dose group, treats low dose group, every group each 10, while setting normal group 10.Died during medication
Statistics is not participated in.
Chinese medicine composition of the present invention is prepared according to formula as below：125g Radix Notoginseng, 208g leech, 41.2g Radix Astragalis, 8.3g ice
Piece, 20.8g lotus nuts, the 20.8g stems of noble dendrobium, 41.2g Rhizoma Gastrodiaes, 4.2g scorpios, 20.8g ground bettles, are made into various concentration solution
It is spare, it designs according to table 1 and is administered to each group, wherein intraperitoneal injection is primary daily for control group.Administration time is 30 days.Rat lacks
Brain Function of Rats is evaluated respectively with after being administered 30 days for 24 hours after blood.Grouping and medicining condition are shown in Table 1.
Table 1 is grouped and medicining condition
2-2 draws materials
Each group rat gives the anesthesia of 1% yellow Jackets after medication 30 days by 30mg/kg weight, will it is postanesthetic greatly
Mouse, which lies on the back, is fixed on operating table, opens chest, and aortic cannulation cuts off atrium dextrum.First from aorta pressurization perfusion 50mL sterilizings
Physiological saline, then fixed in the neutral 4% paraformaldehyde rows of perfusion 250mL, after perfusion maintains 20min, the rapid brain that takes out is set
In 4% paraformaldehyde fixer 36h, row is outer fixed.
2-3 routine paraffin waxes embed and slice
The coronal incision at optic chiasma by the brain tissue fixed, and in face of this after each coronal cut 5mm fritter brain groups
It knits；Through volume fraction 70%, 80%, 95% × 2,100% × 2 ethyl alcohol is dehydrated step by step；Transparent 2 times of dimethylbenzene；Take brain tissue stone
Wax embeds；Continuous coronal cuts 6 μ m-thicks slice；Piece is opened up, is attached on the glass slide handled through APES.
2-4 immunohistochemical staining programs
Glass slide 3- aminopropyl -3- methoxy silanes (APES) kiss-coating, after brain tissue slice sticks, in 60 on roasting piece machine
~62 DEG C of roasting 30~60min of piece, so that slice close adhesion；Slice dewaxes to water；The fresh configuration 3%H2O2 of distilled water, slice
5~10min of room temperature is placed in inactivating endogenous enzyme.Distillation washing slice 3 times；Compound digestive juice is added dropwise, be placed in room temperature 5~
10min, distillation washing 3 times；Normal serum confining liquid is added dropwise, room temperature 20min gets rid of surplus liquid, do not wash；Appropriate dilution is added dropwise
Primary antibody, 4 DEG C overnight, 0.01mPBS (phosphate buffer) washes 2min × 3 time；Biotinylated goat antimouse/rabbit igg is added dropwise,
20~37 DEG C, 20min, 0.01mPBS washes 2min × 3 time；Dropwise addition reagent SABC (Streptavidin complex), 20~37 DEG C,
20min, 0.01mPBS wash 10min × 4 time；DAB (3,3N- diaminobenzidines) develops the color：Using DAB colour reagent boxes, by 1mL
Distilled water, the ratio of each 1 drop of A, B, C reagent in reagent adding box drop to slice after mixing, color development at room temperature, when control is reacted under mirror
Between.Distill water washing；Haematoxylin is slightly redyed, dehydration, transparent, mounting.
(3) test result
3-1 nervous functions score
Different time nervous function appraisal result is shown in Table 2 after each group rat cerebral ischemia.
Different time nervous function scores after 2 each group rat cerebral ischemia of table
(n=10,)
Note：Compared with model control group,##P ＜ 0.01
Each group comparison among groups are P for 24 hours after rat ischemia>0.05, there was no significant difference, shows each group modeling animal nerve
Functional impairment degree is consistent；30d after medication, control group and medication group make the neurologic impairment of rat substantially reduced, and with
Model group has significant difference, and control group and drug 40mg/kg body recombinations of the present invention are more notable.
3-2 optical microphotograph sem observations
BFGF and vegf expression situation, response intensity criterion in main detection focus of infarct surrouding brain tissue：Big portion born of the same parents
It is that strong positive expresses (+++) that film and endochylema, which sepia person,；After birth and endochylema tinctorial strength weaken, and are weak sun in light brown yellow person
Property expression (+)；Tinctorial strength falls between as positive expression (++)；Few coloring or not colored person are negative expression (-).
BFGF detection of expression the results are shown in Table 3, and vegf expression testing result is shown in Table 4.
Table 3bFGF detection of expression results
(n=10,)
Note：Compared with model control group,##P ＜ 0.01
It is analyzed through Ridit, treatment group's height, middle dose group are compared with normal group, P<0.01, there is pole significant difference；Treatment
Low dose group is compared with normal group, P<0.05, significant difference；Treatment height, middle dose group are compared with model group, P<0.01,
There is pole significant difference；Treats low dose group is compared with model group, P<0.01, there is pole significant difference；Treatment height, middle dose group
Compared with the control group, P<0.01, there is pole significant difference.
Table 4VEGF detection of expression results
It is analyzed through Ridit, treatment group's height, middle dose group are compared with normal group, P<0.01, there is pole significant difference；Treatment
Low dose group is compared with normal group, P<0.05, significant difference；Treatment height, middle dose group are compared with model group, P<0.01,
There is pole significant difference；Treats low dose group is compared with model group, P<0.01, there is pole significant difference；Treatment height, middle dose group
Compared with the control group, P<0.01, there is pole significant difference.
The experimental results showed that administration group compared with normal group, model group and control group, there is ischemia/reperfusion in rats cerebrovascular disease
Apparent therapeutic effect.
Claims (4)
1. a kind of cerebral arterial thrombosis Chinese medicine composition, which is characterized in that be made of following parts by weight traditional Chinese medicinal components：Radix Notoginseng
130-138 parts, 188-230 parts of leech, 37-45 parts of Radix Astragali, 7-9 parts of borneol, 19-23 parts of lotus nut, 19-23 parts of the stem of noble dendrobium, Rhizoma Gastrodiae
37-45 parts, 3-5 parts of scorpio, 19-23 parts of ground bettle.
2. cerebral arterial thrombosis Chinese medicine composition according to claim 1, which is characterized in that the dosage of the Chinese medicine
For：125 parts of Radix Notoginseng, 208 parts of leech, 41.2 parts of Radix Astragali, 8.3 parts of borneol, 20.8 parts of lotus nut, 20.8 parts of the stem of noble dendrobium, Rhizoma Gastrodiae 41.2
Part, 4.2 parts of scorpio, 20.8 parts of ground bettle.
3. the preparation method of cerebral arterial thrombosis Chinese medicine composition according to claim 1, which is characterized in that including with
Lower step：Radix Notoginseng, leech, Radix Astragali, lotus nut, the stem of noble dendrobium, Rhizoma Gastrodiae, scorpio and ground bettle are respectively crushed into fine powder first, cross 100
Mesh sieves, and ratio weighs and is mixed into mixed powder by weight；Then borneol is added to mixing in 8-10 parts of ethyl alcohol, uniformly sprayed
Enter in mixed powder, sealing is bored for 24 hours.
4. the preparation method of cerebral arterial thrombosis Chinese medicine composition according to claim 3, which is characterized in that further
With capsule, tablet, granule, pill or oral solution are made together with pharmaceutically acceptable carrier and excipient.
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| CN109718238A (en) * | 2017-10-31 | 2019-05-07 | 中国中医科学院中药研究所 | A kind of new application of compound treatment ischemic cerebral disease |
| CN113577119A (en) * | 2021-07-21 | 2021-11-02 | 右江民族医学院附属医院 | Action mechanism of pseudo-ginseng on cerebral arterial thrombosis and application of action mechanism |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101411742A (en) * | 2008-11-18 | 2009-04-22 | 山西振东开元制药有限公司 | Capsule for freeing collateral vessels containing astragalus and leech |
| CN102895529A (en) * | 2011-07-27 | 2013-01-30 | 陈冠卿 | Medicine treating apoplexy |
| CN103120763A (en) * | 2011-11-20 | 2013-05-29 | 费佳 | Medicinal composition for treating sequela of cerebral apoplexy |
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| CN101411742A (en) * | 2008-11-18 | 2009-04-22 | 山西振东开元制药有限公司 | Capsule for freeing collateral vessels containing astragalus and leech |
| CN102895529A (en) * | 2011-07-27 | 2013-01-30 | 陈冠卿 | Medicine treating apoplexy |
| CN103120763A (en) * | 2011-11-20 | 2013-05-29 | 费佳 | Medicinal composition for treating sequela of cerebral apoplexy |
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