CN104322507A - Ultra-low-volume liquid agent containing methanesulfonylazole - Google Patents
Ultra-low-volume liquid agent containing methanesulfonylazole Download PDFInfo
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- CN104322507A CN104322507A CN201410556491.8A CN201410556491A CN104322507A CN 104322507 A CN104322507 A CN 104322507A CN 201410556491 A CN201410556491 A CN 201410556491A CN 104322507 A CN104322507 A CN 104322507A
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- bacterium azoles
- oil
- methylsulfonyl bacterium
- low volume
- ultra low
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Abstract
The invention discloses an ultra-low-volume liquid agent containing methanesulfonylazole. The ultra-low-volume liquid agent is characterized in that methanesulfonylazole is taken as an active ingredient, and auxiliary agents and solvents are complemented to be 100% of the content of the ultra-low-volume liquid agent. The ultra-low-volume liquid agent has the advantages of being high in working efficiency, capable of saving water and pesticides and good in pesticide effect.
Description
Technical field
The invention belongs to technical field of pesticide, particularly relate to a kind of agricultural chemicals ultra low volume liquids.
Background technology
For the great disease problem of agricultural, carry out the guide structure optimizing research of disease regulation and control, find safety scientific and efficiently and have green candidate's agricultural chemicals of potential market vitality to be the vital task faced in China's New pesticides discovery basic research.Guide finds it is the key realizing innovation green chemical pesticide, and design optimization synthesizes some class agricultural chemicals guide structures, the green chemical pesticide of development of new low toxicity, low-residual, safety, seems very urgent and important.2007, Guizhou University's fine chemistry industry center with the lead compound gallic acid filtered out in natural products for initiation material, design and synthesis a series of newly containing 1,3,4-thiophene (Evil) di azoly sulfone (sulfoxide) derivative, adopt growth rate method, with fusarium graminearum (
gibberella zeae), botrytis cinerea pers (
botrytis cinerea), Sclerotinia sclerotiorum (
sclerotinia sclerotiorum) etc. disease be tested object, bacteriostatic activity research has been carried out to partial target compound.Result shows, its EC of partial target compound
50value between 2.9-23.3mg/mL, have well suppress disease activity [
bioorg. Med. Chem. 2007,
15, 3981;
bioorg. & Med. Chem.
2008, 16,3632.].
On this basis, carry out more deep study on the synthesis, find methylsulfonyl bacterium azoles (Universal Chinese character name, the Secretariat of national pesticide standard technical committee names), molecular formula: C
9h
7fN
2o
3s.
Under 75-150 gram/ha of consumption, methylsulfonyl bacterium azoles has excellent preventive effect (test approval number: SY 201303170, SY 201400217) to bacteriosises such as bacterial blight of rice, bacterial leaf streak of rice, bacterial wilt of tomato and fruit tree cankers.
Methylsulfonyl bacterium azoles physicochemical property: molecular weight 242.02.Former medicine is acicular crystal, fusing point 102-104 DEG C.Water insoluble, be soluble in conventional organic solvent.Former medicine, to light, thermally-stabilised, easily decomposes under alkali condition (pH10).
Methylsulfonyl bacterium azoles mammalian toxicity: rat acute per os LD
50>383mg/kg.Rat acute is through skin and suck LD
50>2000mg/kg.To the medium stimulation of Rabbits with Acute skin, to the weak sensitization of guinea pig skin.
Methylsulfonyl bacterium azoles eco-toxicity: to Japanese quail acute oral LD
50>2000mg/kg.bw, to newbora baky earthworm honeybee Acute exposure LC
50(14 d) is 138 mg a.i./kg
dry ground,to goat's horn crescent moon algae acute toxicity EC
50(72 h) is 2.54 mg a.i./L, to the half-inhibition concentration EC of Daphnia magna
50(48 h) is 2.31 mg a.i./L.
Summary of the invention
The object of the invention be to prepare a kind ofly can to refrigerate the long period under cryogenic, volatility is low, viscosity the is little ultra low volume liquids containing methylsulfonyl bacterium azoles.
A kind of ultra low volume liquids containing methylsulfonyl bacterium azoles of the present invention, it is with methylsulfonyl bacterium azoles for active component, and auxiliary agent and solvent complement to 100% heavy ultra low volume liquids.
The weight content of described methylsulfonyl bacterium azoles is 0.5% ~ 15%, and auxiliary agent weight content is 1% ~ 20%, and solvent complements to 100%.
Described auxiliary agent is surfactant, synergist, bleeding agent; Surfactant is the combination of a kind of or 2-3 kind in fatty alcohol-polyoxyethylene ether, alkylphenol polyoxyethylene, phenethyl phenol polyethenoxy ether, alkylaryl polyoxyethylene polyoxypropylene ether, aliphatic alcohol polyoxyvinethene phosphate, alkylphenol polyoxyethylene phosphate, phenethyl phenol polyethenoxy ether phosphate, alkylaryl polyoxyethylene polyoxypropylene ether phosphate, castor oil polyoxyethylene ether, neopelex; Synergist is the one in Synergistic Phosphorus, sulfoxide, piperonyl butoxide; Bleeding agent is azone, thiophene ketone, ooze one in T soon.
Described solvent is one in aromatic hydrocarbon solvent, plant oil solvent and polar solvent or 2-4 kind.
Described aromatic hydrocarbon solvent is trimethylbenzene, o-dichlorohenzene or more than C10 heavy aromatics; Described plant oil solvent comprises soybean oil, cottonseed oil, rapeseed oil, castor oil, turpentine oil or esterified vegetable oil; Polar solvent comprises acetophenone, phenmethylol, methyl-sulfoxide, N-methyl pyrrolidone, N, N-dimethyl formamide, N, N-dimethylacetylamide or more than C6 alcohols.
Described more than C10 heavy aromatics is durene, diethylbenzene, methyl-propyl benzene, butylbenzene, methyl naphthalene or two wires oil; Esterified vegetable oil is methyl oleate, ethyl oleate; More than C6 alcohols is n-hexyl alcohol, n-octyl alcohol or terpineol.
The concrete preparation method of ultra low volume liquids containing methylsulfonyl bacterium azoles of the present invention is, in the reaction vessel that band stirs, first with solvent by after active component stirring and dissolving, then add auxiliary component, fully be uniformly mixed, obtain containing methylsulfonyl bacterium azoles ultra low volume liquids; Technological parameter is: it is 60 ~ 250 revs/min that mixing speed controls, and mixing time is 5 ~ 100 minutes, and temperature is normal temperature, and pressure is normal pressure.
The application process of invention is ultra low volume spraying, low-gallonage spraying or ultra low volume electrostatic spray.Usually spray with ultra low volume sprayer, or with electrostatic atomiser spraying, also can add the dilution of a small amount of water and carry out low-gallonage spraying.
Embodiment
Below in conjunction with embodiment, the present invention is described in further detail, but embodiments of the present invention are not limited to the scope that embodiment represents.
Embodiment 1
Prepare 0.1% methylsulfonyl bacterium azoles ultra low volume liquids (counting by weight percentage)
Methylsulfonyl bacterium azoles 0.1%, 1-METHYLPYRROLIDONE 10%, n-octyl alcohol 3%, neopelex 2%, phenethyl phenol polyethenoxy ether 3%, two wires oil complements to 100%;
Preparation technology: in the reaction vessel that band stirs, first with solvent by after active component stirring and dissolving, then add auxiliary component, be fully uniformly mixed, obtain containing methylsulfonyl bacterium azoles ultra low volume liquids;
Technological parameter: mixing speeds control is 60 ~ 250 revs/min, and mixing time is 5 ~ 100 minutes, and temperature is normal temperature, and pressure is normal pressure.
Embodiment 2
Prepare 4% methylsulfonyl bacterium azoles ultra low volume liquids
Methylsulfonyl bacterium azoles 4%, 1-METHYLPYRROLIDONE 10%, n-octyl alcohol 3%, neopelex 2%, alkylaryl polyoxyethylene polyoxypropylene ether 3%, methyl oleate complements to 100%;
Preparation technology and parameter are with embodiment 1.
Embodiment 3
Prepare 5% methylsulfonyl bacterium azoles ultra low volume liquids
Methylsulfonyl bacterium azoles 5%, N, N-dimethyl formamide 10%, n-hexyl alcohol 3%, neopelex 2%, oozes T0.2% soon, castor oil polyoxyethylene ether 2.5%, and soybean oil complements to 100%;
Preparation technology and parameter are with embodiment 1.
Embodiment 4
Prepare 8% methylsulfonyl bacterium azoles ultra low volume liquids
Methylsulfonyl bacterium azoles 8%, N, N-dimethyl formamide 10%, neopelex 2%, phenethyl phenol polyethenoxy ether 1.5%, calcium dodecyl benzene sulfonate 2.5%, turpentine oil complements to 100%;
Preparation technology and parameter are with embodiment 1.
Embodiment 5
Prepare 10% methylsulfonyl bacterium azoles ultra low volume liquids
Methylsulfonyl bacterium azoles 8%, N-methyl pyrrolidone 20%, N, N-dimethyl formamide 7%, phenmethylol 3%, aliphatic alcohol polyoxyvinethene phosphate 3.5%, methyl-propyl benzene complements to 100%;
Preparation technology and parameter are with embodiment 1.
The performance of embodiment 6 methylsulfonyl bacterium azoles ultra low volume liquids
The prepared ultra low volume liquids outward appearance containing methylsulfonyl bacterium azoles is homogeneous oily liquids; Low temperature compatibility is good, at-5 DEG C
Under condition, refrigeration 7d not crystallization and suspension; Volatility is low, and filter paper hangs sends out measurement result, and volatility is lower than 30%;
Employing method of remaining silent measures, and flash-point is greater than 60 DEG C; Viscosity is less than 30 mPas.
Claims (6)
1. containing a ultra low volume liquids for methylsulfonyl bacterium azoles, it is characterized in that: it is with methylsulfonyl bacterium azoles for active component, auxiliary agent and solvent complement to 100% heavy ultra low volume liquids.
2. a kind of ultra low volume liquids containing methylsulfonyl bacterium azoles according to claim 1, the weight content of described methylsulfonyl bacterium azoles is 0.5% ~ 15%, and auxiliary agent weight content is 1% ~ 20%, and solvent complements to 100%.
3. a kind of ultra low volume liquids containing methylsulfonyl bacterium azoles according to claim 1, described auxiliary agent comprises surfactant, synergist, bleeding agent; Surfactant is the combination of a kind of or 2-3 kind in fatty alcohol-polyoxyethylene ether, alkylphenol polyoxyethylene, phenethyl phenol polyethenoxy ether, alkylaryl polyoxyethylene polyoxypropylene ether, aliphatic alcohol polyoxyvinethene phosphate, alkylphenol polyoxyethylene phosphate, phenethyl phenol polyethenoxy ether phosphate, alkylaryl polyoxyethylene polyoxypropylene ether phosphate, castor oil polyoxyethylene ether, neopelex; Synergist is the one in Synergistic Phosphorus, sulfoxide, piperonyl butoxide; Bleeding agent is azone, thiophene ketone, ooze one in T soon.
4. a kind of ultra low volume liquids containing methylsulfonyl bacterium azoles according to claim 1, described solvent is one in aromatic hydrocarbon solvent, plant oil solvent and polar solvent or 2-4 kind.
5. a kind of ultra low volume liquids containing methylsulfonyl bacterium azoles according to claim 4, described aromatic hydrocarbon solvent comprises trimethylbenzene, o-dichlorohenzene or more than C10 heavy aromatics; Described plant oil solvent comprises soybean oil, cottonseed oil, rapeseed oil, castor oil, turpentine oil or esterified vegetable oil; Polar solvent comprises acetophenone, phenmethylol, methyl-sulfoxide, N-methyl pyrrolidone, N, N-dimethyl formamide, N, N-dimethylacetylamide or more than C6 alcohols.
6. the solvent of a kind of ultra low volume liquids containing methylsulfonyl bacterium azoles according to claim 4, described more than C10 heavy aromatics is durene, diethylbenzene, methyl-propyl benzene, butylbenzene, methyl naphthalene or two wires oil; Esterified vegetable oil is methyl oleate, ethyl oleate; More than C6 alcohols is n-hexyl alcohol, n-octyl alcohol or terpineol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410556491.8A CN104322507A (en) | 2014-10-20 | 2014-10-20 | Ultra-low-volume liquid agent containing methanesulfonylazole |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410556491.8A CN104322507A (en) | 2014-10-20 | 2014-10-20 | Ultra-low-volume liquid agent containing methanesulfonylazole |
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| Publication Number | Publication Date |
|---|---|
| CN104322507A true CN104322507A (en) | 2015-02-04 |
Family
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| CN201410556491.8A Pending CN104322507A (en) | 2014-10-20 | 2014-10-20 | Ultra-low-volume liquid agent containing methanesulfonylazole |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5166165A (en) * | 1990-10-20 | 1992-11-24 | Bayer Aktiengesellschaft | Fungicidal agents based on heterocyclically substituted sulphones |
| CN102499247A (en) * | 2011-10-17 | 2012-06-20 | 贵州大学 | Oxadiazole sulfone compound for controlling bacterial crop diseases |
| CN103651368A (en) * | 2013-12-13 | 2014-03-26 | 广西田园生化股份有限公司 | Ultra-low-volume liquid containing picoxystrobin and preparation method of ultra-low-volume liquid |
| CN103798237A (en) * | 2013-11-19 | 2014-05-21 | 广西田园生化股份有限公司 | Ultra-low-volume liquid agent containing boscalid |
-
2014
- 2014-10-20 CN CN201410556491.8A patent/CN104322507A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5166165A (en) * | 1990-10-20 | 1992-11-24 | Bayer Aktiengesellschaft | Fungicidal agents based on heterocyclically substituted sulphones |
| CN102499247A (en) * | 2011-10-17 | 2012-06-20 | 贵州大学 | Oxadiazole sulfone compound for controlling bacterial crop diseases |
| CN103798237A (en) * | 2013-11-19 | 2014-05-21 | 广西田园生化股份有限公司 | Ultra-low-volume liquid agent containing boscalid |
| CN103651368A (en) * | 2013-12-13 | 2014-03-26 | 广西田园生化股份有限公司 | Ultra-low-volume liquid containing picoxystrobin and preparation method of ultra-low-volume liquid |
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Application publication date: 20150204 |