CN104318541B - A kind of processing method of ophthalmology OCT image - Google Patents
A kind of processing method of ophthalmology OCT image Download PDFInfo
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Abstract
The invention discloses a kind of processing method of ophthalmology OCT image, including：The shared position OCT image for choosing any one group of ophthalmology OCT image is standard ophthalmology OCT image, the shared position OCT image and standard ophthalmology OCT image of remaining remaining at least one set of ophthalmology OCT image are matched one by one, corresponding rotation amount and translational movement is tried to achieve；According to the optical path difference of the corresponding locus of OCT image of each one eye position of each group of ophthalmology OCT image, the first deeper OCT image of depth is spliced into；First OCT image obtains the second OCT image through processing；Keep the standard ophthalmology OCT image motionless, the OCT image at other human eye positions chooses the corresponding site of the second OCT image, the optical path difference of the locus according to corresponding to each position OCT image, splicing obtains an ophthalmology OCT image for containing multiple human eye positions.Present approach reduces the complexity of ophthalmology OCT equipment, cost has been saved.
Description
Technical field
The invention belongs to image processing field, be related specifically to using ophthalmology OCT device scans human eye and through computer at
The splicing of obtained ophthalmology OCT image is managed, these ophthalmology OCT images show that ophthalmology OCT equipment detection human eye different depth is obtained
The tomoscan image of the reaction human eye different parts arrived.
Background technology
Three kinds current of OCT technology timesharing domain, frequency domain and frequency sweep.Wherein time domain OCT technology investigation depth is deeper, but speed
Degree is too slow, after tested human eye is dynamic, can influence the faulted scanning pattern of human eye；Frequency domain OCT and frequency sweep OCT system speeds are fast, but detection
The all difficult tomoscan realized to whole human eye of depth, and the technology of corresponding frequency sweep OCT ophthalmic medical equipment is more complicated, cost
Also it is higher；If numerous structural parameters of human eye can not be determined simultaneously, crystalline lens front and rear surfaces curvature or curvature can not be just measured
Distribution, or eye ground curvature or curvature distribution etc..
The patent disclosure of Application No. 201290000031.1 is a kind of to realize that anterior ocular segment and oculi posterior segment measurement are quickly cut
The ophthalmology OCT systems changed, but the system once can only obtain two positions of human eye --- such as cornea and crystalline body front surface
Or the OCT image of cornea and retina, and an ophthalmology OCT image for containing multiple human eye positions can not be obtained.Due to every
Though human eye to be measured is watched the fixation lamp of instrument attentively but still independently eye can not moved during secondary measurement, therefore equipment can not ensure not homogeneous
Human eye to be measured is constant always relative to the position of detection device during measurement, so that image calibration can not be carried out to the OCT image surveyed
Just, the crystalline lens front and rear surfaces of tested human eye and the curvature or curvature distribution of human eye eye ground can not just be drawn.Meanwhile,
The ophthalmology OCT equipment being related in the patent is not deep, it is necessary to which switching device could be while realize above-mentioned people enough because of its investigation depth
Eye multiple positions are switched fast measurement, but the complexity for being switched fast equipment of multiple location will necessarily be greatly improved, so that
Add cost and technical difficulty.
The content of the invention
The invention provides a kind of processing method of ophthalmology OCT image, its object is to solve how to set using ophthalmology OCT
Included for by each group that is switched fast multigroup ophthalmology OCT image-these the multigroup ophthalmology OCT images collected by several times
The OCT image at the shared position of human eye, be processed into one be equivalent to once to collect include the eye at multiple human eye positions
The problem of section's OCT image.
Technical scheme is as follows：
A kind of processing method of ophthalmology OCT image, comprises the following steps：
Ophthalmology OCT equipment gathers at least two groups ophthalmology OCT images by several times by being switched fast, and each group includes at least one
Shared position OCT image；
By at least two groups ophthalmology OCT images through processing obtain one be equivalent to once collect containing more personal
The ophthalmology OCT image of eye position；
Wherein, the shared position be after cornea, crystalline body front surface, crystalline lens any position of surface and retina or
The combination at any two position of person is described to be obtained at least two groups ophthalmology OCT images one and is equivalent to what is once collected through processing
Ophthalmology OCT image containing multiple human eye positions, comprises the following steps：
Any one group of shared position OCT image of at least two groups ophthalmology OCT images is schemed for standard ophthalmology OCT described in choosing
Picture, remaining each group ophthalmology OCT image is translated or translation rotation by rotating respectively, makes remaining each group ophthalmology OCT figures
The shared position OCT image of picture is matched one by one with the standard ophthalmology OCT image respectively, try to achieve it is at least one set of include rotation amount and
The data of translational movement；
- according to the optical path difference of the corresponding locus of each position OCT image of human eye, by ophthalmology OCT image described in each group
It is spliced into the first deeper OCT image of depth；
According to the translational movement and rotation amount of at least one set of data, translation rotation or rotation translation are each by remaining one by one
Group ophthalmology OCT image is spliced into the first deeper OCT image of depth, obtains the second OCT image；
The first OCT image for including the standard ophthalmology OCT image is chosen, the corresponding of second OCT image is chosen
Splice as other human eye positions OCT image, the optical path difference of the locus according to corresponding to each position OCT image at position
To the ophthalmology OCT image for containing multiple human eye positions described in one.
Further：The rotation amount and the translational movement by matching or Auto-matching is obtained manually.
Further：The automatic matching method is：Scanned according to the upper surface each point at the shared position along light beam
Direction or row pixel orientation or the distance radially calculated to lower surface, fit the thickness at the shared position of each measurement
Distribution curve is spent, and draws the translational movement and the rotation amount at the shared position to be matched.
Further：When the shared position is retina, the upper and lower surface is taken on retina respectively
Any two layers, the distance is measured by eye ground OCT image；When the shared position be cornea when, the upper surface and
Lower surface is respectively anterior surface of cornea and posterior surface of cornea, and the distance is measured by cornea OCT image.
Further：The optical path difference of the corresponding locus of each position OCT image of human eye is described each according to measuring
What the length difference of the sample arm of the ophthalmology OCT image system at position was produced.
Further：When the shared position OCT image is cornea OCT image, had in the cornea OCT image strong
Reflecting pole, during substantially vertical by the scanning light beam eye cornea of the strong reflecting pole, flashlight vertically reflects and obtained through cornea；When
When the shared position OCT image is retina OCT image, the retina OCT image has strong reflective spot.
Further：Locus corresponding to any position OCT image of the human eye connects mesh to ophthalmology OCT devices
The distance of object lens is determined according to the reference arm of OCT image system and the length of sample arm when surveying the position.
The beneficial technique effect of the present invention：Due at least two groups ophthalmology OCT images of collection, each group of ophthalmology OCT figure
Shared position as containing human eye, using the OCT image at one group therein of shared position as standard ophthalmology OCT image, its
Under surplus the OCT image of each group through translation rotate or rotation translate, make their shared position OCT image respectively with standard eye
Section's OCT image is matched one by one, tries to achieve at least one set of translation spin data；Meanwhile, at least two groups ophthalmology OCT of collection are schemed
Picture, the optical path difference of the locus corresponding to human eye different parts OCT image in any group of ophthalmology OCT image, splicing
Into the first OCT image that depth is deeper, then according to it is foregoing it is at least one set of translate spin data, to except including standard eye
At least one set of first OCT image beyond first OCT image of section's OCT image carries out rotation translation or translation rotation, obtains
Second OCT image；Finally the first OCT image comprising standard ophthalmology OCT image is remained stationary as, the second OCT image is chosen
Corresponding site as other non-shared positions, the then locus according to corresponding to each position OCT image of human eye optical path difference,
Splicing, which obtains one, includes the OCT image at multiple human eye positions.Should include multiple human eye positions OCT image be equivalent to cost compared with
It is high and the more complicated ophthalmic medical equipment of technical difficulty once gathers the image that multiple human eye positions are obtained.But gather multigroup eye
Cost, the technology of the equipment of section's OCT image realize that difficulty is below once gathering the ophthalmology that multiple human eye positions obtain OCT image
Medical Devices.The ophthalmology OCT image containing multiple human eye positions obtained through handling is used for scanning correction and the refraction school of image
Just, so as to obtaining the human eye important parameter such as crystalline lens front and rear surfaces curvature or curvature distribution；Multiple people's eyes should be contained in addition
Position ophthalmology OCT image can be used for the OCT image for correcting eye ground, so as to obtain curvature or curvature distribution of retina etc.
Parameter, numerous useful human eye parameters are provided for the clinical diagnosis of doctor.In addition, last splicing obtain contain multiple people's eyes
The ophthalmology OCT image of position realizes the OCT image of not homogeneous measurement because eliminating the dynamic influence of the eye produced because repeatedly measuring
Splicing, the cost and technology for reducing ophthalmic medical equipment realize difficulty.
Brief description of the drawings
Fig. 1 is the total flow chart of the present invention；
Fig. 2 is light channel structure sketch of the invention；
The exploded view that Fig. 3 is step S102 in Fig. 1；
Fig. 4 is the light path schematic diagram of once collection cornea OCT image and retina OCT image；
Fig. 5 is the cornea OCT image and retina OCT image once gathered；
Fig. 6 is the light path schematic diagram of once collection cornea OCT image and crystalline body front surface OCT image；
Fig. 7 is the cornea OCT image and crystalline body front surface OCT image once gathered；
Fig. 8 is once the light path schematic diagram of surface OCT image after collection cornea OCT image and crystalline lens；
Fig. 9 is surface OCT image after the cornea OCT image and crystalline lens once gathered；
Figure 10 carries out matching schematic diagram for the cornea OCT image in the cornea OCT image and Fig. 5 in Fig. 7；
Figure 11 is the splicing schematic diagram of cornea OCT image and crystalline body front surface OCT image in Fig. 7, defines the OCT image
For the first OCT image；
Figure 12 be Figure 11 in it is matched after cornea OCT image and through translation rotate or rotation translation crystalline lens before
Surface OCT image, defines the OCT image for the second OCT image；
Figure 13 finally gives through processing, is equivalent to the ophthalmology OCT image containing multiple human eye positions that once gathers.
Figure 14 is that human eye has position OCT image automatic matching method flow chart.
First light channel structure schematic diagram that Figure 15 is switched fast for front and rear section, it is common that the light path, which can be realized using retina,
There is the collection of multigroup ophthalmology OCT image at position；
Second light channel structure schematic diagram that Figure 16 is switched fast for front and rear section, it is shared that the light path, which can be realized using cornea,
The collection of multigroup ophthalmology OCT image at position.
Embodiment
In order that technical problems, technical solutions and advantages to be solved are more clearly understood, tie below
Drawings and Examples are closed, the present invention will be described in further detail.It should be appreciated that specific embodiment described herein is only used
To explain the present invention, it is not intended to limit the present invention.
With reference to Fig. 1, Fig. 1 is the total flow chart of the present invention, is comprised the following steps：
S101：Ophthalmology OCT equipment gathers at least two groups ophthalmology OCT images by several times by being switched fast, and each group includes
At least one shared position OCT image；
S102：At least two groups ophthalmology OCT images are obtained one through processing and are equivalent to containing of once collecting
The ophthalmology OCT image at multiple human eye positions.
Step S101 and step S102 expansion is specifically described below.
With reference to Fig. 2, Figure 15 and Figure 16, during survey anterior ocular segment, oculi posterior segment component in Fig. 2 are 20A or Figure 16 in Figure 15
20B.In Figure 15 and Figure 16, by the mutual cooperation of Y-direction scanning element 11O and rotatable completely reflecting mirror 401-rotating
While Y-direction scanning element 11O, rotatable completely reflecting mirror 401 also does corresponding rotation, so as to change Y-direction scanning element
Paths path between 11O and rotatable completely reflecting mirror 401, is realized quick and precisely real in human eye different depth position
When imaging and it is front and rear section imaging switching.Above-mentioned operation principle and method of work are shown in authorized patent
201290000031.1, it is not repeated herein.But, the ophthalmology OCT equipment of patent 201290000031.1 can not be realized once
Collection includes the OCT image from cornea to retina, can only obtain surface after the cornea, crystalline body front surface, crystalline lens of human eye
With the OCT image of the wherein a part of or wherein a few part in retina.Therefore, step S101 purpose is exactly to obtain
At least two groups ophthalmology OCT images, each of which group contains the OCT image at one of position as human eye.Need
It is bright, in the present invention, no matter the OCT image of collection has several groups, but each group of two of which position for only including human eye.Make
It is exemplary in the present embodiment to have enumerated the situation that shared position is cornea OCT image, and collection for specific one embodiment
Ophthalmology OCT image be three groups.It is the premise of cornea OCT image at shared position if the ophthalmology OCT image of collection is two groups
Under, first group of OCT image is respectively the combination (not shown) of cornea OCT image and retina OCT image, second group of OCT image
For the combination (not shown) of cornea OCT image and crystalline lens OCT image.If the ophthalmology OCT image of collection is three groups, in shared portion
On the premise of position is cornea OCT image, this three groups of ophthalmology OCT images are respectively：Cornea OCT image and retina OCT in Fig. 5
Image is as one group, and the cornea OCT image and crystalline body front surface OCT image in Fig. 7 are as second group, the cornea OCT in Fig. 9
Surface OCT image is used as the 3rd group after image and crystalline lens.It should be noted that shared position is selected as cornea OCT image only
Only it is exemplary, in the case where ophthalmology OCT is two groups, shared position can also select crystalline lens OCT image or view
Film OCT image；In the case where ophthalmology OCT image is three groups, shared position can be the preceding surface OCT image of crystalline lens or crystalline substance
Surface OCT image or retina OCT image after shape body.But, no matter the OCT image at which position of selection human eye is used as human eye
Shared position, the handling principle through handling the ophthalmology OCT image that the width finally obtained contains multiple human eye positions is identical.
Therefore, in following discourse process, human eye has the merely illustrative selection cornea OCT image in position；Simultaneously, although following
Obtained from " at least two groups ophthalmology OCT images " that collects and rotated translation or translation rotation described in step
" at least one set " data, still, with three groups of ophthalmology OCT images as embodiment in being specifically described, and in three groups
Obtained from the rotated translation of that group or translation rotation that wherein two groups are respectively relative to include standard ophthalmology OCT image
Two groups of data, every group of data include rotation amount and translational movement.If it should be noted that the human eye OCT image of collection is three groups
More than, the handling principle of image with for two groups or be three groups principle it is identical.
After at least two groups of ophthalmology OCT images are obtained using step S101, by least two groups ophthalmology OCT images
A series of processing is carried out, splicing has obtained an ophthalmology OCT image for including multiple human eye positions, this includes more personal
Eye position ophthalmology OCT image be equivalent to once gather from cornea to crystalline lens after surface ophthalmology OCT image.But once adopt
The equipment complexity and cost for collecting the obtained ophthalmology OCT image containing multiple human eye positions are significantly larger than of the invention described
At least two groups ophthalmology OCT images of collection used in ophthalmology OCT equipment, therefore, using the present invention method, reduce ophthalmology
The complexity and technology of OCT equipment realize difficulty, so as to save cost.
For step S102, Fig. 3 is shown in specific expansion.Fig. 3 is the exploded view of step 201 in Fig. 1, is comprised the following steps：
S201：Any one group of shared position OCT image of at least two groups ophthalmology OCT images described in choosing is standard ophthalmology
OCT image, remaining each group ophthalmology OCT image is translated or translation rotation by rotating respectively, makes remaining described each group ophthalmology
The shared position OCT image of OCT image is matched one by one with the standard ophthalmology OCT image respectively, and tries to achieve at least one set respectively
Data including translational movement and rotation amount；
S202：According to the optical path difference of the corresponding locus of each position OCT image of the human eye, by ophthalmology described in each group
OCT image is spliced into the first deeper OCT image of depth；
S203：According to the translational movement and rotation amount of at least one set of data, one by one translation rotation or rotation translation by
Remaining each group ophthalmology OCT image is spliced into the first deeper OCT image of depth, obtains the second OCT image；
S204：The first OCT image for including the standard ophthalmology OCT image is chosen, second OCT image is chosen
Corresponding site is used as other human eye positions OCT image, the light path of the locus according to corresponding to each position OCT image
Difference, splicing obtains an ophthalmology OCT image for containing multiple human eye positions.
The concrete analysis of the step of above-mentioned S201-S204 will be by being described below.
For at least two groups ophthalmology OCT images mentioned in step S201, by the anterior ocular segment in Fig. 2, Figure 15 and Figure 16, eye
Deutomerite component is collected by being switched fast.In the present embodiment, the ophthalmology OCT image obtained is three groups, is respectively：Fig. 5
In cornea OCT image and retina OCT image as one group, cornea OCT image in Fig. 7 and crystalline body front surface OCT figures
As second group, surface OCT image is used as the 3rd group after the cornea OCT image and crystalline lens in Fig. 9.From above-mentioned three groups of ophthalmology
It is standard ophthalmology OCT image by the shared position OCT image of the group, by remaining two groups of ophthalmology OCT optional one group in OCT image
Image is translated or translation rotation by rotating, and the OCT image at their shared position is entered respectively with standard ophthalmology OCT image
Row is matched one by one.It is mentioned here to match one by one, refer to the shared position OCT image difference of remaining two groups of ophthalmology OCT image
Individually matched with standard ophthalmology OCT image.By matching one by one, at least two groups data are obtained, each group of data include
Translational movement and rotation amount.As specific one embodiment, in the present embodiment, the cornea OCT image in ophthalmology OCT image is taken
To have position.With reference to Figure 10, Fig. 6 and Fig. 7, Figure 10 is carried out for the cornea OCT image in the cornea OCT image and Fig. 5 in Fig. 7
Schematic diagram is matched, Fig. 6 is the light path sketch of the OCT image shown in collection Fig. 7.In the present embodiment, Fig. 5 is included into cornea
Cornea OCT image in OCT image C1 and retina OCT image R1 first group of ophthalmology OCT image is chosen for standard ophthalmology OCT
Image, will include second group of ophthalmology OCT image of surface image LF2OCT images before cornea OCT image C2 and crystalline lens in Fig. 7
In cornea OCT image C2 and Fig. 5 in cornea OCT image C1 matched.Please continue to refer to Figure 10, by the cornea in Fig. 7
OCT image C2 region of interest is represented by dashed line, and these region of interest are：Anterior surface of cornea CF2, posterior surface of cornea CB2, cornea
Strong reflecting pole CCRL2.Being represented with chain-dotted line for the intermediate state that the region of interest is rotated through translation or rotation is translated, is changed into:It is flat
The strong reflecting pole CCRL22 of the peaceful angle of lag films of posterior surface of cornea CB22 before angle of lag film after surface C F22, translation.It is defined on flat
On the basis of shifting it is rotated again after cornea OCT image it is indicated by the solid line, be now changed into：Postrotational anterior surface of cornea
CF23, postrotational posterior surface of cornea CB23, the strong reflecting pole CCRL3. of postrotational cornea now by first translate afterwards rotate
Cornea OCT image C2 in Fig. 7 and Fig. 5 without any rotation translation as " standard ophthalmology OCT image " cornea OCT image
C1 is completely superposed.In the matching process, computer can draw water of the cornea OCT image C2 in translation rotary course in Fig. 7
Translation momentum is Δ X2, and vertical shift amount is Δ Y2, and the anglec of rotation is Δ θ 2.Computer stores corresponding numerical value, is subsequently to do
Prepare.It should be noted that the cornea OCT image C2 in Fig. 7 can also be realized by way of first rotating and translating afterwards with Fig. 5
Cornea OCT image C1 matched, its result with after foregoing first translation rotation as.In addition, the cornea OCT figures in Fig. 9
The matching process and matching schematic diagram (not shown) of cornea OCT image in picture and Fig. 5 are with the cornea OCT image and Fig. 5 in Fig. 7
In cornea OCT image carry out matching process it is identical；After cornea OCT image matching in cornea OCT image and Fig. 5 in Fig. 9
Another group of data are obtained, this group of data also include rotation amount and translational movement.
For step S202, after the three groups of ophthalmology OCT images collected, in addition it is also necessary to by the people of each group of OCT image
The OCT image at each position of eye, according to the optical path difference of corresponding locus, is spliced into the first deeper OCT image of depth.Specifically
Ground, reference picture 11, the first OCT that Figure 11 is obtained after the splicing for cornea OCT image and crystalline body front surface OCT image in Fig. 7
Image.Define corresponding to the locus CDK to crystalline body front surface OCT image corresponding to the cornea OCT image in Figure 11
Locus LFDK distance is LCDKtoLFDK, according to Fig. 4, LCDKtoLFDK=LLFDKto206-LCDKto206, should be away from
From can be measured by the length difference of angle measurement film OCT image system and the sample arm for surveying crystalline body front surface OCT image system, the distance
Optical path difference required for splicing as cornea OCT image in Figure 11 and crystalline body front surface OCT image.And picture centre line because
The light path primary optical axis of OCT systems is to overlap when angle measurement film and survey crystalline body front surface, therefore the center line in Figure 11 is both angle measurement
The center line of the corresponding OCT image of film light path primary optical axis, is also to survey the corresponding OCT image of crystalline body front surface light path primary optical axis
Center line.It should be noted that Figure 11 it is merely illustrative enumerated the first OCT image for before cornea OCT image and crystalline lens
The splicing situation of surface OCT image, if being shown in Figure 11 as surface OCT schemes after the cornea OCT image and crystalline lens in Fig. 9
Cornea OCT image and retina OCT image as shown in the either Fig. 5 of the first OCT image by splicing is by splicing
First OCT image, it is identical that it splices principle, is also locus according to corresponding to cornea OCT image to table after crystalline lens
The distance of locus corresponding to the OCT image of face or the corresponding locus of cornea OCT image are schemed to retina OCT
As the distance of corresponding locus is tried to achieve.By step S202, obtained three groups of depth by splicing it is deeper first
OCT image.
After step S202 is completed, step S203 is subsequently entered.Step S203 purpose is exactly will be in step S202
In three groups of obtained first deeper OCT images, choose respectively comprising surface after crystalline body front surface OCT image and crystalline lens
That two group of first OCT image of OCT image, is carried out by using the corresponding rotation amount and translational movement obtained in step s 201
Rotation translation or translation rotation, obtain two groups of second group of OCT images.Specifically, Figure 12 is refer to, as it was previously stated, measurement angle
Film and crystalline body front surface OCT image are still represented by dashed line, and the anterior surface of cornea OCT image obtained still includes：Cornea
Preceding surface OCT image CF2, posterior surface of cornea OCT image CB2 and the strong reflecting pole CCRL2 of cornea, the crystalline body front surface obtained
LensF2 OCT image is also represented by dashed line.Utilize the amount of the moving horizontally Δ X2, vertical shift amount Δ obtained in step s 201
Y2 and anglec of rotation Δ θ 2 is translated and rotated to the cornea in Figure 12 and crystalline body front surface OCT image.As foregoing,
Represented after the translation of cornea OCT image with chain-dotted line, be specially：Anterior surface of cornea CF22, translation after posterior surface of cornea CB22 and
The strong reflecting pole CCRL22 of cornea after translation；Then it is rotated again to be changed into indicated by the solid line：Postrotational anterior surface of cornea CF23,
The strong reflecting pole CCRL3 of postrotational posterior surface of cornea CB23, postrotational cornea.For Surface L ensF2 before crystalline lens, pass through
It is changed into what is represented with chain-dotted line after translation：Surface L ensF22 before crystalline lens after translation, then rotation is changed into indicated by the solid line
Surface L ensF23 before postrotational crystalline lens.It is the second OCT image to define the ophthalmology OCT image obtained after step S203.Need
It is noted that in this step, Surface L ensF2 OCT image can also first pass through rotation before cornea OCT image and crystalline lens
By being rotated up to same effect after translation is realized and first passed through in translation after turning, do not stated herein tired.In addition, in three groups
Be left that OCT image of group first, that is, the deeper surface OCT after cornea OCT image and crystalline lens that includes of the depth that obtains schemes
That OCT image of group first of picture carry out rotation translation or translation spinning solution with obtain depth it is deeper include cornea OCT
Image is identical with the processing method of that the first OCT image of group of crystalline body front surface OCT image, but before used data are
Another group of data that cornea OCT image in Fig. 9 that face was said is obtained after being matched with the cornea OCT image in Fig. 5.
After step S203 is completed, next enter step S204.In step S204, human eye has position OCT figures
As choosing that group in step s 201 as standard ophthalmology OCT image.Specifically, have position OCT image and choose Fig. 5
In cornea OCT image；The OCT image of other non-shared parts chooses the corresponding site in the second OCT image.Specifically, join
Figure 13 is examined, cornea OCT image uses the cornea OCT image C1 in Fig. 5, and Surface L ensB33 OCT image is chosen before crystalline lens
The OCT image on surface chooses the phase of corresponding second OCT image after the corresponding site of the second OCT image in Figure 12, crystalline lens
Answer position.After the selection of each position OCT image of human eye is completed, according to each position --- cornea OCT image, crystalline body front surface
The optical path difference of locus after OCT image and crystalline lens corresponding to the image of surface OCT image, being spliced into a width depth can reach
To measurement cornea to the OCT image on surface after crystalline lens.Specifically, with reference to Figure 13, the locus corresponding to cornea OCT image
The distance of locus LBDK corresponding to CDK to surface OCT image after crystalline lens is LCDKtoLBDK, and the distance is by angle measurement film
The length difference of the sample arm of surface OCT image system is measured after OCT image system and survey crystalline lens, i.e. LCDKtoLBDK=
LLBDKto206-LCDKto206.In fig. 13, OCT systems when picture centre line is because of angle measurement film and survey crystalline lens front and rear surfaces
Light path primary optical axis is to overlap, so being also to overlap in detail in this figure.According to the optical path difference through splicing, finally give including
OCT image of the cornea to surface after crystalline lens.
Cornea OCT image is refer in step s 201 translates or translate the method that rotation is matched by rotating,
This method can be using matching by hand or through image procossing Auto-matching.The present invention, which is also described, a kind of can realize Auto-matching
Method, realizing is included using cornea OCT image or retina OCT image as the matching process at shared position, its specific method
See Figure 14.Figure 14 comprises the following steps：
S301：Described in calculating on the upper surface of the OCT image at the shared position of at least two groups ophthalmology OCT images each point to edge
The distance of corresponding each point, and is fitted at least two groups distance profiles radially or along pixel column to lower surface；
S302：Using wherein one distance profile as standard, using remaining described distance profile and be used as mark
That accurate distance profile carries out related calculation, and obtains the amount of moving horizontally Δ X, the vertical shift of Auto-matching of Auto-matching
Measure Δ Y and anglec of rotation Δ θ.
Specifically, respectively by the anterior surface of cornea image and cornea of the obtained cornea OCT image in Fig. 5, Fig. 7 and Fig. 9
Surface image, then calculates the distance of the relevant position on each point to posterior surface of cornea on anterior surface of cornea image afterwards.Such as
Calculate anterior surface of cornea on distance of each point along pixel column to posterior surface of cornea, or calculating anterior surface of cornea on each point radially
To multiple distances of posterior surface of cornea, distance profile is fitted according to multiple distances.With the angle measurement film in Fig. 5 and regard
The cornea front and rear surfaces spacing distribution curve fitted in the cornea OCT image obtained during nethike embrane OCT image as standard, its
Cornea front and rear surfaces spacing distribution curve corresponding to its time obtained cornea OCT image of collection does phase with above-mentioned standard curve
Close and calculate, obtain the Auto-matching amount of moving horizontally Δ Xi, Auto-matching vertical shift amount Δ Yi and anglec of rotation Δ θ i.
It should be noted that Figure 14 method also is adapted for realizing Auto-matching using retina OCT image as common sites,
If from retina OCT image, between the internal limiting membrane layer ILM1 and layer of retina,pigment epithelium RPE1 that can use retina OCT image
Any two layers respectively as the upper and lower surface in step S301, it is corresponding automatic by being tried to achieve with Figure 14 identical methods
Water distribution translation momentum, Auto-matching vertical shift amount and the anglec of rotation.Retina is can recognize that on other retina OCT image
Sandwich construction, therefore the selection of above-mentioned upper and lower surface also may be selected other layers to realize above-mentioned matching process.Retina is from top to bottom
Including internal limiting membrane, nerve fibre layer, ganglion-cell layer, inner plexiform layer, inner nuclear layer, outer plexiform layer, outer nuclear layer, external limiting membrane, column and
Taper photosensory cell and retinal pigment epithelium.Just refer to for any two layers mentioned here it is above-mentioned in include internal limiting membrane and bag
Containing any two layers between retinal pigment epithelium, for example, can be internal limiting membrane and nerve fibre layer, nerve fibre layer and Intranet
Layer, or outer nuclear layer and nerve fibre layer, are not being enumerated herein.
It should be noted that in the present invention, if the shared position OCT image cornea OCT in the OCT image gathered
, then there is strong reflecting pole in cornea OCT image in image, during substantially vertical by the scanning light beam eye cornea of the strong reflecting pole, letter
Number light vertically reflects and obtained through cornea；If the shared position OCT image chosen is retina OCT image, retina OCT figures
Strong reflective spot is often occurred that as in.
It should be noted that in the present invention, the OCT image at any position of human eye connects mesh object lens to ophthalmology OCT systems
Distance be according to survey the position when the reference arm of OCT image system and the length of sample arm determine.Specifically, Fig. 4
In, during the OCT image for the cornea for surveying anterior ocular segment, locus CDK corresponding to cornea OCT image to connect mesh object lens 206 away from
It is system given value from LCDKto206, because the value is the reference arm and sample arm of the cornea OCT image system according to anterior ocular segment is surveyed
Length determine.In Fig. 6, during the OCT image for the crystalline body front surface for surveying anterior ocular segment, crystalline body front surface OCT image institute is right
The locus LFDK answered to connect mesh object lens 206 apart from LLFDKto206 be system given value, because the value be according to survey at the moment
What the reference arm of the crystalline body front surface OCT image system of section and the length of sample arm were determined.In Fig. 8, the crystalline of anterior ocular segment is surveyed
After body during the OCT image on surface, locus LBDK after crystalline lens corresponding to the OCT image of surface to connect mesh object lens 206 away from
It is system given value from LLBDKto206, because the value is the reference according to surface OCT image system after the crystalline lens for surveying anterior ocular segment
What the length of arm and sample arm was determined.
It should be noted that in the present invention, although only enumerated the cornea OCT figures in the ophthalmology OCT image with collection
As shared position, still, for taking other positions of human eye, such as surface OCT after crystalline body front surface OCT image, crystalline lens
Image and retina OCT image one of them or with table after cornea OCT image, crystalline body front surface OCT image, crystalline lens
The combination of any two images of face OCT image and retina OCT image is as shared position, and it splices principle and with cornea
OCT image is the same as shared position, and can also obtain one includes the ophthalmology OCT image at multiple human eye positions.Obviously, the party is used
As the ophthalmology OCT image that method is obtained is with the effect of the OCT image obtained using cornea OCT image as shared position.
By step S201 to step S204, the ophthalmology OCT image that three groups of collection include human eye different parts is spliced
The OCT image once gathered for being equivalent to shown in Figure 13, it is achieved thereby that cornea is adopted to the OCT image on surface after crystalline lens
Collection, has expanded the investigation depth of system in the technical sophistication degree for not increasing system light path.That is, by image
Processing, realizes the splicing of the not OCT image of homogeneous measurement, makes the figures of the ophthalmology OCT including multiple human eye positions finally obtained
The influence dynamic as eliminating human eye to be measured eye, its effect reached and once gathers human eye with more complicated ophthalmology OCT equipment
The obtained ophthalmology OCT image including multiple human eye positions is the same.Moreover, what is obtained includes multiple people's eyes through what splicing was obtained
The OCT image of position can be used for the scanning correction and refraction correction of image, so as to obtain crystalline lens front and rear surfaces curvature or song
The human eye important parameters such as rate distribution.According further to the series of parameters on surface after cornea to crystalline lens, it can be used to correcting eyeground and regard
The OCT image of nethike embrane, the important human eye parameter such as curvature or curvature distribution so as to obtain retina, is the clinical diagnosis of doctor
Numerous useful human eye parameters are provided.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
Any modifications, equivalent substitutions and improvements made within refreshing and principle etc., should be included in the scope of the protection.
Claims (7)
1. a kind of processing method of ophthalmology OCT image, it is characterised in that comprise the following steps：
Ophthalmology OCT equipment gathers at least two groups ophthalmology OCT images by several times by being switched fast, and each group shared comprising at least one
Position OCT image；
By at least two groups ophthalmology OCT images through processing obtain one be equivalent to once collect contain multiple people's eyes
The ophthalmology OCT image of position；
Wherein, the shared position is any position of surface and retina or to appoint after cornea, crystalline body front surface, crystalline lens
Anticipate the combination at two positions；
It is described by least two groups ophthalmology OCT images through processing obtain one be equivalent to once collect contain multiple people's eyes
The ophthalmology OCT image of position, comprises the following steps：
Any one group of shared position OCT image of at least two groups ophthalmology OCT images described in choosing is standard ophthalmology OCT image,
Remaining each group ophthalmology OCT image is translated or translation rotation by rotating respectively, makes remaining each group ophthalmology OCT image
Shared position OCT image is matched one by one with the standard ophthalmology OCT image respectively, is tried to achieve at least one set of including rotation amount and translation
The data of amount；
According to the optical path difference of the corresponding locus of each position OCT image of human eye, ophthalmology OCT image described in each group is spliced into
The first deeper OCT image of depth；
According to the translational movement and rotation amount of at least one set of data, translation rotation or rotation translation are by remaining each group eye one by one
Section's OCT image is spliced into the first deeper OCT image of depth, obtains the second OCT image；
The the first ophthalmology OCT image for including the standard ophthalmology OCT image is chosen, the corresponding of second OCT image is chosen
Splice as other human eye positions OCT image, the optical path difference of the locus according to corresponding to each position OCT image at position
To the ophthalmology OCT image for containing multiple human eye positions described in one.
2. the processing method of ophthalmology OCT image as claimed in claim 1, it is characterised in that：The rotation amount and the translation
Amount is obtained by matching or Auto-matching manually.
3. the processing method of ophthalmology OCT image as claimed in claim 2, it is characterised in that：The automatic matching method is：Root
Calculated according to the upper surface each point at the shared position along light beam scanning direction or row pixel orientation or radially to lower surface
Distance, fit the thickness distribution curve at the shared position of each measurement, and draw the shared position to be matched
The translational movement and the rotation amount.
4. the processing method of ophthalmology OCT image as claimed in claim 3, it is characterised in that：When the shared position is view
During film, the upper and lower surface is taken any two layers on retina respectively, and the distance is surveyed by eye ground OCT image
；When the shared position is cornea, the upper surface is anterior surface of cornea, and the lower surface is posterior surface of cornea, described
Distance is measured by cornea OCT image.
5. the processing method of the ophthalmology OCT image as any one of claim 3-4, it is characterised in that：The human eye is each
The optical path difference of the corresponding locus of position OCT image is the sample according to the ophthalmology OCT image system for measuring each position
What the length difference of arm was produced.
6. the processing method of the ophthalmology OCT image as any one of claim 2-3, it is characterised in that：The shared portion
When position OCT image is cornea OCT image, strong reflecting pole is had in the cornea OCT image, the strong reflecting pole is by scanning light
During the substantially vertical eye cornea of beam, flashlight vertically reflects and obtained through cornea；When the shared position OCT image is retina
During OCT image, the retina OCT image has strong reflective spot.
7. the processing method of the ophthalmology OCT image as any one of claim 3-4, it is characterised in that：Any of human eye
Locus corresponding to the OCT image of position to the distance for connecing mesh object lens of ophthalmology OCT devices be according to OCT when surveying the position
The reference arm of imaging system and the length of sample arm are determined.
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