CN104146681B - One kind of an image correction method retinal oct - Google Patents

One kind of an image correction method retinal oct Download PDF

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CN104146681B
CN104146681B CN201410402851.9A CN201410402851A CN104146681B CN 104146681 B CN104146681 B CN 104146681B CN 201410402851 A CN201410402851 A CN 201410402851A CN 104146681 B CN104146681 B CN 104146681B
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image
lens
surface
oct
scanning beam
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CN104146681A (en
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蔡守东
吴蕾
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深圳市斯尔顿科技有限公司
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Abstract

本发明公布了一种眼底视网膜OCT图像校正方法,包括:扫描光束扫描眼前节和眼后节,同时得到经计算机处理的未校正的包含角膜OCT图像、晶状体前表面OCT图像、晶状体后表面OCT图像的人眼前节OCT图像和眼底视网膜OCT图像;将上述OCT图像校正还原成真实形态的图像,得到角膜前表面曲率半径、角膜后表面曲率半径、晶状体前表面曲率半径、晶状体后表面曲率半径、角膜厚度、前房深度和晶状体厚度;确定出扫描光束经晶状体后表面折射后扫描光束中心线的汇聚点(O45),求出扫描扇形区域圆心位置及扫描角度(uO45);将未校正的眼底视网膜OCT图像还原成真实形态的图像,根据测得的眼前节OCT图像和眼后节OCT图像,最终还原得到眼底视网膜真实的断面图像,测得眼底视网膜曲率。 The present invention discloses a method for correcting retinal OCT image, comprising: scanning beam scanning anterior segment and the posterior segment, while processed by the computer to obtain uncorrected OCT image comprising the cornea, the front surface of the OCT image of the lens, posterior surface of the OCT image human anterior segment OCT image and the retinal OCT image; the above-described OCT image correction reduced to the image of the real form, to obtain the radius of the anterior corneal surface curvature, the corneal surface curvature radius, front radius of curvature of the surface of the lens, the radius of the lens surface curvature of the cornea thickness, anterior chamber depth and lens thickness; determining a rear refractive surface of the scanning beam after the convergence point of the lens scanned beam centerline (Marlipal® O45), and obtains the center position of the scanning angle of a scanning fan-shaped area (uO45); retinal uncorrected OCT image is reduced to form the real image, according to the anterior segment and the posterior segment OCT image OCT image is measured, to give the final reduction of cross-sectional images of the real retinal, retinal measured curvature.

Description

一种眼底视网膜OCT图像校正方法 One kind of an image correction method retinal OCT

技术领域 FIELD

[0001] 本发明属于光电子技术领域,具体涉及一种眼底视网膜0CT图像校正方法。 [0001] The present invention belongs to the field of photonics technology, particularly relates to an image correction method 0CT retina.

背景技术 Background technique

[0002] 如今众多眼科诊断仪器被用于测量人眼的众多参数,来帮助医生对患者的眼病进行诊断。 [0002] Today, many ophthalmic diagnostic instruments are used to measure a number of parameters of the human eye, to help doctors diagnose the patient's eye. 但现有技术中,对于人眼晶状体前后表面曲率及人眼眼底视网膜的曲率,没有准确、无损、可靠的测量方法。 However, the prior art, for the lens of the eye before and after the surface curvature and the curvature of the human eye retina, is not accurate, non-destructive, a reliable measurement.

[0003] 目前的0CT技术分时域、频域和扫频三种。 [0003] Current technology 0CT sharing domain, frequency domain, and sweep three. 其中时域0CT技术探测深度较深,但速度太慢,被测人眼动后,会影响人眼的断层扫描图;频域和扫频0CT系统速度快,但探测深度都难实现对整个人眼的断层扫描。 Wherein the time-domain technique 0CT investigation depth, but the speed is too slow, the measured eye movement, affects the human eye tomography scan; fast sweep and frequency domain 0CT system speed, but are difficult to achieve depths of the whole person eye tomography. 若无法同时测定人眼的众多结构参数,就无法测得眼底视网膜曲率等。 If a number of structural parameters can not be measured while the human eye, it can not be measured curvature retina.

[0004] 现有的技术中提供了一种人眼多个部位的一次测量依次快速切换成像的方案,但所测的0CT图像是经过计算机处理后得到的各部位的矩形0CT图像,该矩形0CT图像无法反映视网膜0CT真实的断层图的形状,因此根据该矩形0CT图像无法直接得出被测人眼的眼底视网膜的曲率。 [0004] The prior art provides for a plurality of portions of the human eye measurement fast switching scheme sequentially imaged, but the image is measured 0CT 0CT rectangular image after each portion obtained by computer processing, the rectangle 0CT the image does not reflect the real shape of the retina tomogram 0CT therefore can not draw the measured curvature of the fundus of the eye retina directly according to the image of the rectangular 0CT.

发明内容 SUMMARY

[0005] 本发明提供了一种视网膜0CT成像后的校正方法,其目的在于解决无法从经计算机处理得到的未校正的矩形眼底视网膜0CT图像测得眼底视网膜曲率的缺陷。 [0005] The present invention provides a method of correcting a retina 0CT after imaging an object to solve the drawbacks of the uncorrected rectangle can not be processed by the computer from the retinal image 0CT retinal measured curvature.

[0006] 本发明的技术方案如下: [0006] aspect of the present invention is as follows:

[0007] -种眼底视网膜0CT图像校正方法,包括如下步骤: [0007] - species 0CT retinal image correction method, comprising the steps of:

[0008] 扫描光束扫描眼前节和眼后节,同时得到经计算机处理的未校正的包含角膜0CT 图像、晶状体前表面0CT图像、晶状体后表面0CT图像的人眼前节0CT图像和眼底视网膜0CT图像; [0008] The beam scanning anterior segment and posterior segment of the scan, and get processed by the computer uncorrected comprising cornea 0CT image, the lens front surface 0CT image, retrolental human face 0CT image anterior segment 0CT image and the retinal 0CT image;

[0009] 将所述角膜0CT图像、所述晶状体前表面0CT图像和所述晶状体后表面0CT图像校正还原成真实形态的眼前节0CT图像,并从所述校正后的眼前节0CT图像中得到角膜前表面曲率半径、角膜后表面曲率半径、晶状体前表面曲率半径和晶状体后表面曲率半径、角膜厚度、前房深度和晶状体厚度; [0009] The image 0CT cornea, the front surface of the lens and the image 0CT the rear surface of the lens image correction 0CT 0CT reduced to the anterior segment image of the real shape of the cornea and anterior segment to obtain the corrected image 0CT in radius of curvature of the front surface, a rear surface radius of curvature of the cornea, the radius of curvature of the lens front surface and the rear surface of the lens radius of curvature, corneal thickness, anterior chamber depth and lens thickness;

[0010] 确定出扫描光束经晶状体后表面折射后扫描光束中心线的汇聚点(045),求出扫描扇形区域圆心位置及扫描角度(u045); [0010] After it is determined that the scanning beam scans the surface refracted posterior centerline beam convergence point (045) to obtain the center position of the scan region and scan sector angle (U045);

[0011] 将所述未校正的眼底视网膜0CT图像还原成真实形态的图像。 [0011] The retinal 0CT uncorrected image of the real image is reduced to form.

[0012] 进一步地:所述扫描角度(U045)是根据公式 [0012] Further: the scanning angle (U045) is according to the formula

[0013] u045 =y•u04 求得; [0013] u045 = y • u04 obtained;

[0014] 其中,y表示眼前节的整体角放大率,根据扫描光束依次经角膜前表面、角膜后表面、晶状体前表面和晶状体后表面折射后在所述扫描光束中心线汇聚点汇聚后计算得到; u04表示扫描光束扫描眼后节0CT图像时出射接目物镜时的扫描角度。 [0014] where, y represents a whole angular magnification of anterior segment, calculating the point of convergence of the scanning beam centerline aggregation obtained by sequentially after the front surface of the cornea, the back surface, a front surface and a posterior refractive surface of the lens in accordance with the scanning beam ; scan angle at the exit eyepiece section showing the objective lens u04 0CT image scanning beam scans the eye.

[0015] 进一步地,将所述未校正的眼底视网膜OCT图像还原成真实形态的图像,具体包括: [0015] Further, the uncorrected retinal OCT image is reduced to form a real image, comprises:

[0016] 将所述未校正的眼底视网膜0CT图像划分为(2m+l)列像素; [0016] The uncorrected image into a retinal 0CT (2m + l) column of pixels;

[0017] 根据扫描角度(u045),将所述(2m+l)列像素进行平移旋转或者旋转平移,得到校正后的眼底视网膜0CT图像。 [0017] The scanning angle (U045), the (2m + l) columns of pixels in translation or rotation of the rotary pan, 0CT retinal image obtained after the correction.

[0018] 进一步地:所述根据求得的扫描角度(u045)将所述(2m+l)列像素分别进行平移旋转或者旋转平移的具体步骤包括: [0018] Further: the specific steps were obtained according to a scanning angle (U045) to the (2m + l) columns of the pixel shift rotation or rotational translation comprising:

[0019] 选取所述所述(2m+l)列的像素的任意第K列像素,确定其旋转角度 [0019] Select the (2m + l) any column of pixels in the pixel column of K, which determines the angle of rotation

Figure CN104146681BD00061

[0020] 求出所述扫描光束经晶状体后表面折射后扫描光束中心线的汇聚点(045)到所述未校正的眼底视网膜0CT图像顶端所对应的空间位置RDK2的距离L045toRDK2 ; [0020] After obtaining the scanning beam scans the surface refracted posterior centerline beam convergence point (045) to the distance uncorrected 0CT retinal image corresponding to the spatial position of the top of RDK2 L045toRDK2;

[0021] 求出未校正的眼底视网膜OCT图像的第K列像素的顶端的第一像素点在校正后的眼底视网膜0CT图像中所处的第一位置的坐标; [0021] The first point to the top of the pixel is determined uncorrected OCT image of the fundus retina K column of pixels located in 0CT retina corrected image coordinates of a first position;

[0022] 先将所述未校正的第K列像素整列平移,并使所述第一像素点处于所述第一位置,然后以所述第一位置为第一圆心,以所述角度uk旋转经过平移后的第K列像素,完成所述第K列像素的校正;或者先以所述第一像素点在未校正的眼底视网膜0CT图像的所在位置为第二圆心,将所述第K列像素以角度uk旋转,然后将经过旋转后的第K列像素整列平移,并使所述第一像素点处于所述第一位置,完成所述第K列像素的校正; [0022] The first uncorrected K-th column of pixels aligned translation, and the first pixel point in the first position, then at the first position of the first circle, at said angle of rotation uk after the K-th column of pixels of the shifted, the correction is completed K-th column of pixels; location or prior to the first pixel in the uncorrected image of the fundus retina 0CT a second center, the first column K pixel uk rotation angle, and then translating the row of pixels aligned after rotation through the first K, and the first pixel point in the first position, the first K columns of pixels to complete the correction;

[0023] 用和校正第K列像素相同办法校正其余2m列像素,将所述未校正的眼底视网膜0CT图像还原成其真实形态的图像。 [0023] and corrected by the same correction approaches K-th column of pixels remaining 2m columns of pixels, the uncorrected image 0CT retinal image is reduced to its true form.

[0024] 进一步地:所述眼前节的整体角放大率Y的计算公式为: [0024] Further: the angle of the anterior segment of the overall amplification factor Y is calculated as:

Figure CN104146681BD00062

[0025] 其中,L045表不扫描光束经晶状体后表面折射后扫描光束中心线的汇聚点到晶状体后表面的距离,L0441表示扫描光束经晶状体前表面折射后扫描光束中心线汇聚点到晶状体后表面的距离,L044表示扫描光束经晶状体前表面折射后扫描光束中心线汇聚点到晶状体前表面的距离,L0431表示扫描光束经角膜后表面折射后扫描光束中心线汇聚点到晶状体前表面的距离,L043表示扫描光束经角膜后表面折射后扫描光束中心线汇聚点到角膜后表面的距离,L0421表示扫描光束经角膜前表面折射后的扫描光束中心线汇聚点到角膜后表面的距离,L042表示扫描光束经角膜前表面时折射后的扫描光束中心线汇聚点到角膜前表面的距离,L04表示扫描光束经接目物镜后扫描光束中心线汇聚点到角膜前表面的距离。 After [0025] wherein, L045 table without scanning beam refracted by the posterior surface of the scanning beam convergence point distance from the centerline to the rear surface of the lens, L0441 represents the scanning beam after the lens front refractive surface of the scanning beam to the surface of the lens centerline convergence point distance, L044 represents a scanning beam after the lens front refractive surface of the scanning beam to the centerline distance between the front surface of the convergence point of the lens, L0431 a rear surface of the scanning beam refracted by the cornea after scanning beam convergence point to the centerline distance between the front surface of the lens, L043 a scanning light beam refracted by the corneal surfaces after scanning beam converged from the centerline to the point of the corneal surface, L0421 represents the center line of the scanning beam after the scanning beam refracted by the corneal surfaces converging from the point to the corneal surface, L042 represents a scanning beam when the anterior corneal surface through the center line of the scanning beam after the convergence point distance to the front refractive surface of the cornea, L04 represents a scanning beam through the objective lens after the ocular convergence point scanning beam centerline distance between the front surface of the cornea.

[0026] 进一步地:所述扫描光束经角膜前表面时折射后的扫描光束中心线汇聚点是根据公式 [0026] Further: scanning beam after the convergence point centerline refractive surface of the scanning beam when the cornea is according to the formula premenstrual

[0027] [0027]

Figure CN104146681BD00063

求得, Seek,

[0028]其中:ne"_为角膜折射率,n_表示空气折射率;rto_F为角膜前表面曲率半径, 该值为校正后的眼前节0CT图像获得。 [0028] wherein: ne "_ corneal refractive index, a refractive index of N_ represents air; rto_F is the radius of the anterior corneal surface curvature, anterior segment image 0CT the correction value is obtained.

[0029] 进一步地:所述扫描光束经角膜后表面折射后扫描光束中心线汇聚点是根据公式 [0029] Furthermore: after said scanning beam over the cornea after the convergence point of the scanning beam centerline refractive surface is according to the formula

[0030] [0030]

Figure CN104146681BD00071

求得, Seek,

[0031] 其中:nAq_us表示眼前节房水折射率,rto_B为角膜后表面曲率半径,该值由校正后的眼前节0CT图像中获得;所述扫描光束经角膜后表面折射后扫描光束中心线汇聚点处于瞳孔附近。 [0031] wherein: nAq_us anterior segment represents a refractive index of aqueous humor, rto_B corneal radius of curvature of the surface, the values ​​obtained from the anterior segment image after correction 0CT; rear surface of the scanning beam refracted by the cornea center line scanning beam converged point in the vicinity of the pupil.

[0032] 进一步地:所述扫描光束经晶状体前表面折射后扫描光束中心线汇聚点是根据公式: [0032] Further: the scanning beam after the lens front refractive surface of the scanning beam centerline convergence point according to the formula:

[0033] [0033]

Figure CN104146681BD00072

求得; Determined;

[0034] 其中,nUns表示晶状体折射率;r^sF为晶状体前表面曲率半径,由校正后的眼前节0CT图像中获得。 [0034] wherein, Nuns represents the refractive index of the lens; r ^ sF is the radius of curvature of the lens front surface, obtained from the anterior segment image 0CT correction.

[0035] 进一步地:所述扫描光束经晶状体后表面折射扫描光束中心线的汇聚点根据公式 Refractive surface converging spot scanning beam center line after the scanning beam according to the formula of the lens by: [0035] Further,

[0036] [0036]

Figure CN104146681BD00073

財导; Choi lead;

[0037] 其中,nVlt_us为玻璃体的折射率;rUnsB为晶状体后表面曲率半径,由校正后的眼前节0CT图像中获得。 [0037] wherein, nVlt_us is the refractive index of the glass body; rUnsB curvature radius of the lens rear surface is obtained by the anterior segment image after correction 0CT.

[0038] 进一步地:所述未校正的眼前节0CT图像由一张0CT图像构成或者由二至三张0CT图像合成;若由一张0CT图像构成,则该张0CT图像包含角膜0CT图像、晶状体前表面0CT图像、晶状体后表面0CT图像;若由两张0CT图像合成,则第一张为角膜0CT图像和晶状体前表面0CT图像,第二张为晶状体后表面0CT图像或者第一张为角膜0CT图像,第二张为晶状体前表面0CT图像和晶状体后表面0CT图像;若由三张0CT图像合成,则每张0CT图像为角膜0CT图像、晶状体前表面0CT图像和晶状体后表面0CT图像的任一张;所述未校正的眼前节0CT图像的张数由系统探测深度决定。 [0038] Further: the uncorrected image of an anterior segment 0CT 0CT image composed of two to three or 0CT synthesized image; if the image constituted an 0CT, the image sheet comprises 0CT 0CT corneal image, the lens 0CT front surface image, the rear surface of the lens image 0CT; 0CT if the two image synthesis, the first image and a cornea 0CT 0CT image anterior lens surface, second surface or the first image 0CT posterior corneal 0CT image, the second sheet after the front surface of the lens surface of the lens and the image 0CT 0CT image; if the three 0CT image synthesis, the image is a corneal 0CT 0CT each image, an image after any surface 0CT 0CT image and a lens surface of the lens front sheets; uncorrected number of sheets of the anterior segment image 0CT determined by the depth of the system.

[0039] 本发明的有益的技术效果:通过在设备上一次性同时得到眼前节0CT图像和眼后节0CT图像,确定扫描光束中心线扫描视网膜时最终的汇聚点,在依次采集好角膜前表面0CT图像、角膜后表面0CT图像、晶状体前表面0CT图像和晶状体后表面0CT图像的基础上,将计算机处理得到的未校正的视网膜矩形0CT图像划分为(2m+l)列,根据最终扫描角度u045,利用公式 [0039] The advantageous technical effects of the present invention is: through the final point of convergence simultaneously obtain disposable 0CT anterior segment and posterior segment 0CT image on an image device, the scanning beam to determine the center line of scanning the retina, the anterior corneal sequentially acquired good base 0CT image surface 0CT image of the cornea, the front surface of the lens 0CT image and the posterior 0CT image surface, uncorrected retinal rectangular computerized obtained 0CT image is divided into (2m + l) columns, in accordance with the final scan angle u045 using the formula

Figure CN104146681BD00074

求得(2m+l)列中任意第K列像素的旋转角度uk,将(2m+l)列像素进行旋转平移或者平移旋转,使之和扫描光束经过眼底视网膜上时的实际光路相同,完成矩形视网膜0CT图像的校正,得到还原的反映眼底视网膜真实形状的0CT图像,从而测得眼底视网膜曲率。 Obtained (2m + l) columns of any of the first K columns of pixels rotational angle UK, the (2m + l) columns of pixels of rotation and translation or translation rotated so that the sum of the scanning light beam through retinal same actual optical path during the complete 0CT retina corrected rectangular image, to obtain images that reflect 0CT true shape of the retinal reduced, so that the measured curvature retina.

附图说明 BRIEF DESCRIPTION

[0040] 图1为测人眼前后节0CT图像系统结构简图; [0040] FIG. 1 is a system configuration diagram of the image sensing section 0CT sight;

[0041] 图2为测眼前节0CT图像示意图; [0041] FIG. 2 is a schematic view of an image sensing 0CT anterior segment;

[0042] 图3为测眼后节0CT图像示意图; [0042] FIG. 3 is a schematic view of the image sensing section 0CT eye;

[0043] 图4为测眼前节OCT图像示意图; [0043] FIG. 4 is a schematic diagram of the measured anterior segment OCT image;

[0044] 图5为各眼前节0CT示意图; [0044] FIG. 5 is a schematic 0CT respective anterior segment;

[0045] 图6为未矫正的合成的眼前节0CT图像示意图; [0045] FIG. 6 is a synthesized image of the anterior segment 0CT schematic uncorrected;

[0046] 图7为眼前节0CT图像扫描模式校正示意图; [0046] FIG. 7 is a front section 0CT schematic image scanning mode correction;

[0047] 图8为眼前节0CT图像角膜前表面以下折射校正示意图; [0047] FIG. 8 is a schematic front correction 0CT anterior segment image of the corneal surface refractive or less;

[0048] 图9为眼前节0CT图像角膜前表面以下折射率校正示意图; [0048] FIG. 9 is a schematic front section 0CT surface correction before the image of corneal refractive index;

[0049] 图10为眼前节0CT图像角膜后表面以下折射校正示意图; [0049] FIG. 10 is a rear 0CT anterior segment image of the corneal surface refractive correction the schematic;

[0050] 图11为眼前节0CT图像角膜后表面以下折射率校正示意图; [0050] FIG. 11 is a front surface of the refractive correction 0CT section view after the image of the cornea;

[0051] 图12为眼前节0CT图像晶状体前表面以下折射校正示意图; [0051] FIG. 12 is a front section 0CT schematic front surface of the refraction-corrected image of the lens;

[0052] 图13为眼前节0CT图像晶状体前表面以下折射率校正示意图; [0052] FIG. 13 is a schematic view of the surface of the refractive correction anterior segment 0CT front lens image;

[0053] 图14为测眼后节0CT图像扫描光束中心线入射人眼前节情况示意图; [0053] FIG. 14 is a schematic diagram of the eye measurement section 0CT image scanning beam incident on the center line of sight of the case section;

[0054] 图15为测眼后节0CT图像扫描光束中心线入射人眼前节情况示意图续; [0054] FIG. 15 is a centerline section of the scanning beam incident on the image 0CT sight measurement section where the schematic eye continued;

[0055] 图16为原眼底视网膜0CT图像; [0055] FIG. 16 is a retinal 0CT original image;

[0056] 图17为校正后的眼底视网膜图像; [0056] FIG. 17 is a retina corrected image;

[0057] 图18为图14中的A处放大图; [0057] A of FIG. 18 is an enlarged view of FIG 14;

[0058] 图19为图15中的B处放大图; [0058] FIG. 19 is an enlarged view at B of Figure 15;

[0059] 图20为本发明的流程图; [0059] FIG. 20 is a flowchart of the present invention;

[0060] 图21为图20中步骤S103的分解步骤图; [0060] FIG. 21 is a step S103 in FIG. 20 FIG decomposition step;

[0061] 图22为眼底视网膜0CT图像校正平移步骤图; [0061] FIG. 22 is a retinal image correcting step of translating FIG 0CT;

[0062]图23为本发明的系统光路的其中一个实施例; [0062] FIG. 23 of the present invention, an optical path system of one of the embodiments;

[0063] 图24为第K列像素的第一像素点在完成校正后的眼底视网膜0CT图像的第一位置的坐标计算示意图。 [0063] FIG. 24 is a K-th column of pixels of the first pixel coordinate calculating a first position of a schematic image of the fundus retina 0CT after the completion of the correction.

具体实施方式 Detailed ways

[0064] 为了使本发明所要解决的技术问题、技术方案及有益效果更加清楚明白,以下结合附图及实施例,对本发明进行进一步详细说明。 [0064] In order to make the technical problem to be solved by the present invention, technical solutions and beneficial effects clearer, the accompanying drawings and the following embodiments, the present invention will be further described in detail. 应当理解,此处所描述的具体实施例仅用以解释本发明,并不用于限定本发明。 It should be understood that the specific embodiments described herein are merely used to explain the present invention and are not intended to limit the present invention.

[0065] 本发明主要叙述的是将计算机处理的未经校正的矩形眼底视网膜0CT图像还原成眼底视网膜真实形态的0CT图像。 [0065] The present invention is described uncorrected rectangular computerized 0CT retinal retinal image is reduced to form a real image 0CT. 在还原的过程中,需要求得扫描光束扫描眼底视网膜的扫描扇形区域圆心位置及扫描角度u045。 In the process of reduction, it is necessary to obtain a sector scan region of the scanning beam scans the center position and the retinal scan angle u045. 扫描角度u045是根据u045 =y*1104求得。 U045 scanning angle is determined according u045 = y * 1104. 其中,Y表示眼前节的整体角放大率,它是根据扫描光束中心线依次经角膜前表面、角膜后表面、晶状体前表面和晶状体后表面折射后在所述扫描光束中心线汇聚点汇聚后计算得到;u04表示扫描光束扫描眼后节0CT图像时出射接目物镜但未进入角膜前表面时的扫描角度。 Wherein, Y represents the overall angular magnification of anterior segment, which is the front surface sequentially through the cornea, the back surface, a front surface and a posterior refractive surface of the lens is calculated according to the center line of the scanning beam in the scanning beam after the convergence point centerline aggregation obtained; u04 represents the exit section when the scanning beam scans the image 0CT eyepiece ocular lens but when the scanning angle into the front surface of the cornea. 为求出Y,需要求出角膜前表面曲率半径、角膜后表面曲率半径、晶状体前表面曲率半径、晶状体后表面曲率半径、角膜厚度、前房深度、晶状体厚度等参数。 To obtain Y, is necessary to obtain the front surface of the corneal radius of curvature, the radius of curvature of the surface parameters, radius of curvature of the front surface of the lens, posterior surface radius of curvature, corneal thickness, anterior chamber depth, lens thickness and other corneal. 角膜前表面曲率半径需要通过校正后的角膜前表面0CT图像得到,角膜后表面曲率半径需要通过校正后的角膜后表面0CT图像得到,晶状体前表面曲率半径需要通过校正后的晶状体前表面0CT图像得到,晶状体后表面曲率半径需要通过校正后的晶状体后表面0CT图像得到,角膜厚度、前房深度、晶状体厚度均需要通过校正后的人眼前节0CT图像得到。 Front radius of curvature of the surface of the cornea requires the front surface of the cornea after the correction 0CT images obtained, the surface radius of curvature required corneal obtained by the rear surface of the cornea after the correction 0CT image, front radius of curvature of the lens surface needs to be obtained by 0CT image of the lens front surface of the corrected , the radius of curvature of the posterior surface of the lens need corrected images obtained by surface 0CT, corneal thickness, anterior chamber depth, lens thickness are required by human anterior segment 0CT obtained corrected image. 在本专利申请文件中,将花大篇幅的文字叙述角膜前表面OCT图像、角膜后表面OCT图像、晶状体前表面OCT图像和晶状体后表面0CT图像的校正,为最后的眼底视网膜0CT图像的校正做铺垫。 In the present patent application, the take great length narrative anterior corneal surface OCT image, the surface OCT image of the cornea, the correction surface 0CT image after image and lens of the lens front surface OCT, do to correct the final retinal 0CT image bedding.

[0066] 参考图1和图23,图1为测人眼前后节0CT图像系统结构简图,测眼前节和测眼后节过程中共用接目物镜206和测眼前、后节0CT图像组件207,且共用一个系统光路(见图23),图23中的系统光路通过光程补偿模块200能实现眼前节眼后节成像以及在眼前节眼后节成像之间的切换,光程补偿模块200配合眼前节眼后节扫描构件100,改变0CT成像系统的光程,在人眼的不同部位如角膜、晶状体前表面、晶状体后表面和视网膜上进行0CT成像,并能在这些成像部位之间实现相互切换,计算机得到了包括角膜0CT图像、晶状体前表面0CT图像和晶状体后表面0CT图像的眼前节0CT图像以及视网膜0CT图像。 [0066] Referring to FIG. 1 and FIG. 23, FIG. 1 is a rear sight measurement section 0CT system configuration diagram of the image, the anterior segment and test segment of the eye measured by the CPC process and measuring the ocular lens 206 in front, the assembly section 207 image 0CT and a common system light path (see FIG. 23), the system in FIG. 23 the optical path through the optical path compensation module enables 200 in front of posterior segment ocular segment imaging and after an anterior segment ophthalmic switching between the segment imaging, the optical path compensation module 200 scanning member with the anterior segment posterior section 100, to change the optical path of the imaging system 0CT, 0CT performed on different parts of the image of the eye such as the cornea, the front surface of the lens, and the posterior surface of the retina, and can be realized between the imaged site each switch comprises a computer to obtain an image 0CT cornea, anterior segment front surface of the lens and the retinal image 0CT 0CT 0CT image after image surface and lens 0CT image. 从图23可以看出,眼前节0CT图像和眼后节0CT图像的获得都是在同一台设备上一次完成。 As can be seen from FIG. 23, and the anterior segment image obtained 0CT 0CT image section is a posterior done on the same device. 假如眼前节0CT图像和眼后节0CT图像是在不同设备上测量获得,则无法同时保证人眼到眼科设备的距离的一致性,也无法保证让测眼前节及测眼后节光路系统的主光轴重合。 If anterior segment and posterior segment 0CT 0CT image is an image obtained by the measurement on different devices, can not simultaneously guarantor Yandao coherence distance ophthalmic device, can not ensure that the test measured anterior segment and posterior segment of the main light optical system axis coincides. 需要说明的是,计算机得到的眼前节0CT图像和眼底视网膜0CT图像都是未校正的矩形0CT图像,而不是反映人眼真实的断面图像。 It should be noted that the computer receives an anterior segment and retinal image 0CT 0CT uncorrected image is rectangular 0CT image, rather than reflecting the true cross-sectional images of the human eye. 因此,只有对这些未校正的眼前节0CT图像和眼底视网膜0CT图像校正还原,才能得到反映人眼真实的断面图像。 Therefore, only those uncorrected image 0CT anterior segment and retinal 0CT image correction to restore order to the human eye reflected the true cross-sectional images. 从校正后的眼前节0CT图像和眼底视网膜0CT图像中能够得到角膜前表面曲率半径、角膜后表面曲率半径、晶状体前表面曲率半径、晶状体后表面曲率半径、角膜厚度、晶状体厚度、前房深度和眼底视网膜的曲率。 From the anterior segment image and the retinal 0CT 0CT corrected image can be obtained in the radius of curvature of the front surface of the cornea, the corneal radius of curvature of a rear surface, a curvature radius of the front surface of the lens, posterior surface radius of curvature, corneal thickness, lens thickness, anterior chamber depth, and the curvature of the fundus retina.

[0067] 参考图2,其中,测眼前节的角膜的0CT图像时,角膜0CT图像顶端所对应的空间位置CDK到接目物镜206的距离LCDKt〇206(参考图4)为系统已知值,因该值是根据测眼前节的角膜0CT成像系统的参考臂和样品臂的长度决定的。 [0067] Referring to FIG 2, wherein, when the image sensing 0CT anterior segment of the cornea, the cornea 0CT top of the image corresponding to the spatial position of the ocular lens CDK distance LCDKt〇206 206 (refer to FIG. 4) known values ​​for the system, this value is due to the length of the reference arm and the sample arm 0CT corneal anterior segment imaging system sensing determined.

[0068] 参考图2,测眼前节的晶状体前表面的0CT图像时,晶状体前表面0CT图像顶端所对应的空间位置LFDK到接目物镜206的距离为系统已知值,因该值是根据测眼前节的晶状体前表面0CT成像系统的参考臂和样品臂的长度决定的。 [0068] Referring to FIG 2, when the front surface of the lens image 0CT measured anterior segment, the front surface of the lens to the top 0CT image corresponding to the spatial position of the ocular lens LFDK distance 206 is a known value for the system, because of the value of the measured the reference arm and the sample arm, the length of the front surface of the front lens of the imaging system 0CT decision section. 另外,由上述眼前后节0CT成像系统也能测得被测人眼角膜Ec到接目物镜206的距离,方法是:角膜0CT图像顶端所对应的空间位置CDK到接目物镜206的距离为系统已知值,结合所测得的角膜0CT图像,从图像中能够测得角膜0CT图像顶端所对应的空间位置CDK到角膜的距离,从而得出角膜到接目物镜206的距离。 Further, the front section by the imaging system 0CT person to be measured can be measured by the cornea Ec from the objective lens to the eyepiece 206, the method is: the top of the cornea 0CT image corresponding to the spatial position of the CDK from the ocular lens system 206 known values, in conjunction with the cornea 0CT measured image, the image can be measured to the top of the cornea 0CT spatial position corresponding to the distance of the cornea from the CDK image to arrive at the objective lens from the cornea to the eyepiece 206. 测眼前节的晶状体后表面的0CT图像时,晶状体后表面0CT图像顶端所对应的空间位置LBDK到接目物镜206的距离为系统已知值,因该值是根据测眼前节的晶状体后表面0CT成像系统的参考臂和样品臂的长度决定的。 Retrolental 0CT measured when the anterior segment image surface, the posterior surface of the top of the image corresponding 0CT spatial position LBDK distance of the objective lens to the eyepiece system 206 is a known value, because the value is measured after the lens front surface section according 0CT the reference arm and the sample arm length of the imaging system determined. 测眼后节的视网膜的0CT图像时, 视网膜0CT图像顶端所对应的空间位置RDK2到接目物镜206的距离为系统已知值,因该值是根据测眼后节0CT成像系统的参考臂和样品臂的长度决定的。 After the test eye image of the retina when 0CT section, the top of the retinal image 0CT spatial position corresponding to the distance from the ocular lens 206 RDK2 for the system known value, because the value is measured after the reference arm section 0CT eye imaging system and the arm length of the sample determined.

[0069] 参考图5,角膜前表面到角膜后表面的距离能由图5中的角膜0CT图像中获得。 [0069] Referring to FIG 5, the anterior corneal surface to the corneal surface can be obtained by the distance from the cornea 0CT image in FIG. 5. 角膜后表面到晶状体前表面的距离,也就是前房深度,该值结合角膜0CT图像、晶状体前表面0CT图像及测角膜和晶状体前表面时光路的光程差便可求得。 Corneal surface to the distance from the front surface of the lens, i.e. anterior chamber depth, corneal 0CT the combined value image, the optical path difference before and 0CT image sensing surface of the cornea and the front surface of the lens, the optical path of the lens can be obtained. 晶状体厚度,该值结合晶状体前后表面0CT图像及测晶状体前后表面时光路的光程差便可求得。 Lens thickness, the optical path difference value binding 0CT image surface and surface, the optical path of the front lens can be obtained before and after the test lens. 另外晶状体后表面到视网膜的距离,该值由晶状体后表面的0CT图像结合视网膜的0CT图像,及测晶状体后表面和测视网膜时光路的光程差便可求得。 After an additional distance from the lens surface to the retina, the value of the posterior surface of the image 0CT binding 0CT image of the retina, the lens and the measurement surface and measuring the optical path difference, the optical path of the retina can be obtained. 前面说过,未校正的眼前节0CT图像包含角膜0CT图像、晶状体前表面0CT图像、晶状体后表面0CT图像,该眼前节0CT图像可由一张0CT图像中得到,或者由二至三张0CT图像合成得到。 As mentioned above, the uncorrected image including the anterior segment of the cornea 0CT 0CT image, the front surface of the lens image 0CT, retrolental surface 0CT image, the anterior segment image obtained by a 0CT 0CT image, or the image combining two to three 0CT get. 0CT图像张数具体取决于0CT系统的探测深度。 0CT number of images depending on the depth of 0CT system. 即系统探测深度浅时,角膜、晶状体前后表面由同一系统分三次快速采集得到,分别得到未校正的角膜OCT图像、晶状体前表面OCT图像和晶状体后表面OCT图像;此时未校正的眼前节OCT图像由上述三张OCT图像合成。 When the system detects a shallow depth i.e., the cornea, the lens front and rear surfaces of the same system in three portions to obtain fast acquisition, respectively uncorrected OCT image of the cornea, the front surface of the OCT image and the OCT image lens surface of the lens; uncorrected case anterior segment OCT image synthesis by the three OCT image. 系统探测深度深时,由两张OCT图像合成得到, 这里又分为两种:一种是第一张OCT图像包含角膜OCT图像和晶状体前表面OCT图像,第二张OCT图像包含晶状体后表面OCT图像;另外一种情况就是第一张OCT图像包含角膜OCT 图像,第二张OCT图像包含晶状体前表面OCT图像和晶状体后表面OCT图像。 When the system detects deep depth, obtained by the OCT image synthesizing two, here is divided into two: one is the first image comprises OCT corneal OCT image and the OCT image front surface of the lens, the second image comprising a posterior surface of OCT OCT image; another case is the first image including corneal OCT OCT image, the second image containing OCT OCT anterior lens surface and a rear surface of the lens image OCT image. 当然,若由两张OCT图像组成时,这两张OCT图像亦可有交叠区域,如都含有晶状体前表面OCT图像,此时可通过图像处理,取消交叠区域,拼接出所需的从角膜到晶状体后表面的OCT图像。 Of course, if the two OCT image composition, which may also have two OCT image overlap areas, such as the front surface of the lens contains an OCT image, then image processing can be canceled overlap region, the required stitching from cornea to the posterior surface of the OCT image. 系统探测深度更深时,未校正的眼前节OCT图像则由一张OCT图像得到,例如图5中未校正的眼前节OCT图像就是由角膜OCT图像、晶状体前表面OCT图像和晶状体后表面OCT图像三张独立的OCT图像合成。 When the system detects deeper, uncorrected anterior segment OCT image obtained by an OCT image, for example, in Figure 5 the uncorrected image is anterior segment OCT OCT image by the cornea, the front surface of the lens rear surface of the lens image and the OCT OCT image three OCT image combining separate single.

[0070] 参考图2,测眼前节0CT图像时,测眼前节0CT图像组件的扫描装置(图22中109 或者110)扫描,扫描光束中心线汇聚于图2中的01点。 [0070] Referring to FIG 2, when measured 0CT anterior segment image, the scanning means measuring the anterior segment image 0CT assembly (109 or 110 in FIG. 22) scanning, the scanning beam converges on the center line 01 in FIG. 2 points. 扫描光束经接目物镜206后,其中心线汇聚于02点。 After the scanning beam through the eyepiece lens 206, which converge at the center line 02 points. 01、02的位置由测眼前节0CT图像组件及接目物镜206共同决定,且为系统预设。 01,02 position determined by measurement of anterior segment image 0CT assembly and the eyepiece lens 206, and is the system default. 另外当01处于接目物镜206的右方焦点时,02点便移至无穷远,此时扫描光束中心线与系统光路的主光轴平行。 Further, when the objective lens 01 in the right eyepiece focal point 206, the point 02 will be moved to infinity, then the scanning beam center line and the main optical axis is parallel to the optical path of the system. 测角膜及晶状体前后表面时,0CT光束聚焦于眼前节中部区域,能有效提高角膜、晶状体前后表面测量时,0CT图像的信噪比及横向分辨率。 When measuring front and back surfaces of the cornea and lens, the beam is focused on the anterior segment 0CT middle region, can improve the cornea, the lens front surface measured, and SNR 0CT lateral resolution image. 并且若扫描光束中心线平行主光轴入射人眼,有利于角膜及晶状体前后表面的折射校正。 And if the scanning beam incident on the main optical axis parallel to the centerline of the human eye, before and after the correction of corneal refractive beneficial and lens surface.

[0071] 参考图3,测眼后节0CT图像时,测眼后节0CT图像组件中的扫描装置(图23中109或者110)扫描,而扫描光束中心线汇聚于03点。 [0071] Referring to FIG 3, when the measuring section 0CT eye image, after sensing section 0CT eye image scanning apparatus assembly (109 or 110 in FIG. 23) scans the scanning beam center line 03 converge at the point. 扫描光束经接目物镜206后,其中心线汇聚于04点。 After the scanning beam through the eyepiece lens 206, which converge at the center line 04 points. 03、04的位置由测眼后节0CT图像组件及接目物镜206共同决定,且为系统预设的。 03, 04 of the 206 positions determined by the image component measuring 0CT segment of the eye and the eyepiece lens, and is preset in the system. 即04点到接目物镜206的距离L04to206为系统预设值。 I.e., mesh access point 04 from the objective lens system 206 L04to206 preset value. 其中眼后节0CT图像组件中的扫描装置能够与眼前节0CT图像组件中的扫描装置共用。 Wherein the scanning device 0CT posterior segment image components can be shared with the anterior segment image components 0CT scanning device. 另外当03点处于接目物镜206的右方无限远时,04点便移至接目物镜206的左方焦点,此时扫描光束中心线汇聚于接目物镜206的左方焦点。 In addition, when the point 03 is at right eyepiece lens 206 at infinity, point 04 will move to the left eyepiece focal point of the objective lens 206, in which case the scanning beam converges on the center line of the left eyepiece focal point of the objective lens 206. 眼后节成像光路系统的探测光束满足扫描光束中心线汇聚于待测人眼瞳孔附近,而任意时刻0CT光束聚焦于人眼眼底。 Probe beam posterior segment imaging center line satisfies the scanning beam converging optical system to be measured in the vicinity of human eye pupil, and any time 0CT beam is focused on the fundus of the human eye. 这样设置使得瞳孔不会挡光, 并且有效提高眼底0CT图像的信噪比和横向分辨率。 Arranged such that the pupil is not blocking light, and improve the signal to noise ratio and fundus 0CT lateral resolution image.

[0072] 因此,图1至图3为能实现上述数据测量的0CT系统部分光路结构图,通过图1到图3的0CT系统,便能进行下述的0CT图像校正。 [0072] Thus, FIGS. 1 to 3 is a part of the optical system can be realized 0CT path structure view of the measured data, it can be corrected by the following 0CT 0CT image system of FIG 1 to FIG 3.

[0073] 1)、眼前节0CT图像的校正 [0073] 1), anterior segment image correction 0CT

[0074] 参考图4,测眼前节0CT图像(包括角膜、晶状体前后表面0CT图像)时,扫描光束中心线的交汇点02到接目物镜206的距离L02t〇206,该值为系统设定值。 When [0074] Referring to FIG 4, the measured 0CT anterior segment image (including the cornea, the front and rear surface of the lens image 0CT), the intersection of the center line of the scanning beam 02 from the objective lens to the eyepiece L02t〇206 206, the system parameter value . 而测角膜0CT 图像实际扫描宽度DCornea由系统扫描装置(图23中109或者110)的扫描幅度及光路决定,该值为系统设定值,从而测眼前节时扫描光束对应的总角度JCornea也就确定。 And the actual measured corneal 0CT image scanning width DCornea (109 or 110 in FIG. 23) and the amplitude of the scanning optical system of the scanning device is determined by the path, which is the system set value, corresponding to the total angle of the scanning beam when it JCornea thereby measuring anterior segment determine.

[0075] 参考图5,系统所得的各眼前节0CT图为计算机得到的未经校正的矩形图,它们并不是各眼前节-角膜前表面、角膜后表面、晶状体前表面和晶状体后表面的真实的0CT图像形状。 5, the resulting histogram of the uncorrected system of each picture shows the front section of computer 0CT obtained, they are not in front of each of the sections [0075] Referring to FIG - corneal front surface, a rear surface of the cornea, the lens front surface and lens rear surface real the 0CT image shape. 其中任一一列图像在理论上对应一扫描光束中心线入射眼前节时0CT系统采集的信号,但实际上,扫描光束中心线由于光路系统的设定以及光束进入人眼后被人眼组织折射, 因而实际扫描光束所经过的路径并非如所得的眼前节0CT图像那样为笔直的一列,因此图5中所得的矩形的眼前节OCT图像并非真实的眼前节形状,它只是计算机处理得到的未经校正的眼前节矩形0CT图像。 Wherein any of eleven scan signal corresponding to the image light beam incident on the center line of the anterior segment 0CT collection system in theory, but in practice, since the scanning beam center line and a beam path is set the system into the eye after eye refractive Organization , so the actual scanning beam path through not as obtained anterior segment 0CT image that is a straight, and therefore FIG obtained in 5 rectangular anterior segment OCT images are not true anterior segment shape, it is only a computer processing obtained without correcting rectangular 0CT anterior segment image. 为了得到真实的眼前节形态,从而得到真实的眼前节结构参数,系统需要对眼前节0CT图像进行校正。 In order to obtain the true shape of the anterior segment, to obtain the true parameters of anterior segment, the system needs to correct the image the anterior segment 0CT.

[0076]系统设定所获得的眼前节0CT图像的横向像素数相同,S卩:测角膜、晶状体前后表面的0CT图像的横向像素数相同,每一列像素对应一扫描光束中心线。 The same number of pixels across the anterior segment image 0CT [0076] The obtained system configuration, S Jie: measuring the cornea, the same number of horizontal pixels 0CT front and rear surfaces of the lens image, each column of pixels corresponding to a scanning beam centerline. 容易理解,扫描光束若沿系统主光轴出射,此时采集的信号对应角膜0CT图像、晶状体前后表面0CT图像、视网膜的0CT图像的中心线。 It is readily appreciated, if the scanning beam along the exit optical axis of the main system, the signal acquired at this time corresponds to the cornea 0CT image, center line surface 0CT image, retinal image before and after 0CT lens.

[0077] 参考图6,定义角膜0CT图像、晶状体前后表面0CT图像各由2n+l列像素构成,其中标注为〇的那一列对应相同的扫描光束中心线。 [0077] Referring to FIG 6, an image defined 0CT cornea, the front and rear surfaces of the lens 0CT image constituted by 2n + l columns of pixels, wherein the row labeled as the square corresponding to the same scanning beam centerline. 其中前房深度用角膜下表面C0点到晶状体前表面F0点间的光程LCOtoFO来表征,该值能由系统测得。 Wherein the anterior chamber depth with the corneal surface to the optical path LCOtoFO C0 point F0 points between anterior lens surface characterized, the measured value can be obtained by the system. 而晶状体厚度用晶状体前表面点到晶状体后表面10点间的光程LFOtoIO来表征,也可以由系统测得。 The lens thickness of the optical path between the LFOtoIO characterized 10:00 rear surface to a point with a front lens surface of the lens, it may be obtained by the measurement system. 根据前房深度光程值LCOtoFO、晶状体厚度光程值LFOtoIO,便可将上述角膜0CT图像、晶状体前后表面0CT图像组合成如图6所示的眼前节0CT图像。 The values ​​of anterior chamber depth of the light path LCOtoFO, lens thickness values ​​of the optical path LFOtoIO, 0CT cornea image can be above, the front and rear surface of the lens 0CT 0CT anterior segment images into the image shown in Figure 6. 图6所示的包括角膜0CT图像、晶状体前后表面0CT图像是未经过校正的眼前节0CT矩形图像。 FIG 6 0CT cornea image, 0CT front surface of the lens image is not a rectangular 0CT anterior segment image after correction. 该矩形0CT图像需要还原成它真实的图像,先要进行扫描校正,即校正成如图7所示的大致为扇形的图形。 The rectangular image needs to be restored to its 0CT real image correction have to be scanned, i.e., the correction pattern substantially as shown in FIG fan 7 shown in FIG.

[0078] 参考图7并结合图4和图6,首先进行扫描模式校正。 [0078] Referring to Figure 7 in conjunction with FIGS. 4 and 6, the first scan mode correction. 如图7所示,每一列像素以眼前节0CT图像的最上端的像素为圆心旋转,其中定义第j列以Aj为圆心,旋转角度为aj, 将眼前节0CT图像第j列像素值进行旋转,并求出剩下的其它列像素对应的旋转角度,然后根据求得的旋转角度将其一一旋转,最终得到如图7中点An、点J0、点An、点Jn2、点J-n2 所围的不规则图形。 7, each column of pixels in the uppermost pixel 0CT anterior segment image as the center of rotation, wherein the j-th column is defined as the center to Aj, AJ rotation angle, the anterior segment image 0CT j-th column pixel value rotation, and obtains the rotational angle of the remaining pixels corresponding to the other column, and the rotation angle of rotation determined to eleven, in FIG. 7 finally obtained middle point An, J0 point, point An, J n2 point, the point J n2 Wai irregular shapes. 旋转角度aj的计算根据以下公式 Calculates the rotation angle according to the following equation aj

[0079] [0079]

Figure CN104146681BD00111

[0080]求出。 [0080] obtained.

[0081] 其中:L02to206表示扫描光束中心线的交汇点02到接目物镜206的距离; IXDKto206表示角膜0CT图像顶端所对应的空间位置⑶K到接目物镜206的距离;|AOAj 表征A0到Aj点的距离: [0081] wherein: L02to206 represents the intersection of the center line of the scanning beam 02 from the objective lens to the eyepiece 206; IXDKto206 represents the top of the cornea 0CT image corresponding to the spatial position of the ocular lens distance ⑶K 206; | AOAj characterizing points A0 to Aj the distance:

Figure CN104146681BD00112

DCornea表示角膜0CT图像实际扫描宽度。 DCornea represents the actual cornea 0CT image scanning width. 因此,通过上面的公式便能求得第j列像素相对于标注为第0列像素旋转的角度。 Accordingly, the above formula will be able to obtain an angle of 0 is denoted by rotating column j of pixels with respect to pixels. 此外,若02点位于接目物镜左方无限远处,是上述情况的特例,此时就无需进行扫描模式校正,g卩aj= 0。 Further, if the point 02 is located in the left eyepiece lens at infinity, the above is a special case, in which case there is no need for correcting the scan mode, g Jie aj = 0. 从扫描模式校正后的眼前节0CT图像中,再识别出角膜前表面轮廓,便能得出准确的角膜前表面曲率分布。 0CT from the anterior segment image after correction in the scanning mode, and then identify the profile of the anterior surface of the cornea, it will be able to arrive at an accurate distribution of the anterior corneal surface curvature.

[0082] 2)角膜前表面以下图像的折射校正 Refraction-corrected [0082] 2) the front surface of the cornea image

[0083] 在完成扫描模式校正后,接着进行角膜前表面以下的图像进行折射校正。 [0083] After completion of the calibration scan mode, then the front surface of the cornea below the refracted image correction. 参考图8并结合图5,前面说过,将眼前节0CT图像分为(2n+l)列,这自然包括了将角膜前表面的0CT图像按照同样的方法划分为(2n+l)列。 Referring to Figure 8 in conjunction with Figure 5, said earlier, the anterior segment image into 0CT (2n + l) columns, which naturally includes the front surface of the cornea 0CT image is divided into (2n + l) columns in the same manner. 将角膜前表面以下每一列像素以角膜前表面为圆心旋转,其中第j列以Bj2为圆心,旋转角度为。 The front surface of the cornea to the front surface of each column of pixels as the center of rotation of the cornea, wherein the j-th column in Bj2 as the center, rotation angle. ilj为扫描光束中心线入射到角膜前表面的Bj2点和法线BJ205形成的入射角;i2j为扫描光束中心线在Bj2到Cj3 之间形成的折射光和法线BJ205形成的折射角,该折射光会在眼前节区域(即角膜后表面至晶状体前表面之间的区域)会再次发生折射。 ilj scanning beam is incident to a center line normal to the front surface Bj2 point and forming an angle of incidence of the cornea BJ205; i2j refraction angle of light refracted scanning beams normal to the center line between Bj2 BJ205 to Cj3 formed is formed, the refractive light refraction will occur again in the region of the anterior segment (i.e., the region between the surface of the cornea to the front surface of the lens rear). 在Bj2点处,角膜前表面的切线与水平线的夹角为0j。 At Bj2 point, the horizontal angle between the tangent and the front surface of the cornea 0j. 0j由所识别的角膜前表面曲率分布中得出,由于aj已经求出,因此,根据公式 0j obtained by the front surface of the cornea curvature distribution identified, since aj have been determined, and therefore, according to the formula

[0084] ilj= 0j-aj [0084] ilj = 0j-aj

[0085] 求出ilj。 [0085] obtained ilj.

[0086] 在ilj已经求得的情况下,根据公式 [0086] In the case ilj been determined, according to the formula

[0087]nairsin(ilj) =ncorneasin(i2j) [0087] nairsin (ilj) = ncorneasin (i2j)

[0088] 求出i2j,其中nair为空气折射率,n。 [0088] determined i2j, where nair is the refractive index of air, n. "_为角膜折射率; "_ Corneal refractive index;

[0089] 在i2j已经求出的情况下,根据公式 [0089] In the case i2j been determined according to the formula

[0090] yj=Pj-i2j [0090] yj = Pj-i2j

[0091] 求出yj。 [0091] obtained yj. yj表征在Bj2点处扫描光束中心线入射角膜前表面后的折射光线Bj2Cj3与竖直直线A0J0的夹角。 yj characterize the vertical angle of the refracted ray Bj2Cj3 straight A0J0 after scanning beam incidence angle at the centerline point Bj2 front surface of the membrane.

[0092] 用同样的办法可以完成角膜前表面以下的0CT图像的其它列像素的折射校正,最终完成角膜前表面以下的0CT图像的折射校正。 [0092] The refractive correction can be done in the other column of pixels below the front surface of the cornea 0CT images using the same approach, the final completion of the anterior corneal surface refractive correction of 0CT image.

[0093] 3)、角膜前表面以下图像的折射率校正 [0093] 3), the refractive index of the front surface of the cornea of ​​the following correction of the image

[0094] 接着进行角膜前表面以下图像的折射率校正。 [0094] Next correcting the refractive index of the front surface of the cornea following images. 因0CT采用光学相干原理,其图像获得的是被测样品的光程信息图,若为了得到眼前节的实际厚度参数,需对角膜前表面以下的图像进行折射率的校正。 0CT by using optical coherence principle, the image information obtained in an optical path view of the sample is measured, in order to obtain an actual thickness parameter when the front section, the front surface of the cornea for an image correcting refractive index less.

[0095] 参考图9,图9为对眼前节0CT图像角膜前表面以下折射率校正示意图,就是将图nc 8中的Bj2到Jj3之间的像素进行压缩,压缩成图9中的Bj2到Jj4,压缩的比率为^"。 n-air 根据所得的眼前节OCT图像角膜前表面以下折射率校正后的图像中识别出角膜后表面轮廓,便能得出准确的角膜后表面曲率分布。 [0095] Referring to FIG 9, FIG. 9 for the front surface of the cornea anterior segment image 0CT the following schematic refractive correction, is to be compressed between the pixel in FIG nc 8 Bj2 to the JJ3, compressed into BJ2 to FIG. 9 Jj4 , the compression ratio of ^ ". n-air identification of the image obtained after the correction of the refractive index of the front surface of the cornea anterior segment OCT image of the corneal surface profile, will be able to arrive at an accurate distribution of corneal surface curvature.

[0096] 4)、角膜后表面以下图像的折射校正 [0096] 4), the surface of the cornea refractive corrected image

[0097] 再次进行角膜后表面以下图像的折射校正。 [0097] surface of the cornea is refracted less corrected image again. 参考图10,将被分割成(2n+l)列的每一列角膜后表面上的像素作为圆心进行旋转,其中第j列以Cj4为圆心,将Cj4到Jj4间的像素值(参考图9)以旋转角度(i3j-i4j)进行旋转,旋转至图10中的Cj4到Jj5。 Referring to FIG 10, the rear surface of each of the pixels on the row is divided into columns of the cornea (2n + l) as a rotation center, wherein the j-th column in Cj4 as the center pixel value to Jj4 between Cj4 (refer to FIG. 9) rotation angle (i3j-i4j) is rotated to rotate to Cj4 Jj5 to 10 in FIG. 其中i3j表征Cj4点处扫描光束中心线入射角膜后表面时和法线Cj406构成的入射角,i4j表征Cj4点处扫描光束中心线入射角膜后表面后和法线Cj406构成的折射角。 Wherein i3j characterized scanning beam spot at the center line of rear Cj4 incident angle normal to the film surface, and when the angle of incidence of the configured Cj406, i4j characterizing the angle of refraction at the scanning point Cj4 beam center line and a normal angle of incidence of the back surface film Cj406 configuration. 在Cj4点处,角膜后表面的切线与水平线的夹角为0 2j。 At Cj4 point, the horizontal angle between the tangent and the rear surface of the cornea is 0 2j. 0 2j由所识别的角膜后表面曲率分布中得出,由于yj已经求出,从而可得i3j= 0 2j-yj。 0 2j curvature distribution derived from the rear surface of the cornea identified, since yj been determined so as to be available i3j = 0 2j-yj.

[0098] 根据公式 [0098] According to the formula

[0099]ncorneasin(i3j) =nAqueoussin(i4j) [0099] ncorneasin (i3j) = nAqueoussin (i4j)

[0100] 在i3j已经求得情况下,并且叫"_和nAq_us为已知值的情况下,求得i4j,然后进一步求出旋转角度(i3j_i4j)。其中nAq_us为眼前节房水折射率,ne"_为角膜折射率。 [0100] In the case where i3j has been obtained, and called "_ case and nAq_us known value, determined i4j, and further obtain the rotation angle (i3j_i4j). NAq_us wherein the refractive index of the anterior segment of aqueous humor, ne "_ corneal refractive index. 最后根据公式 Finally, according to the formula

[0101] y2j=P2j-i4j [0101] y2j = P2j-i4j

[0102] 求得y2j. [0102] obtained y2j.

[0103] 其中,y2j表征Cj4点处扫描光束中心线入射角膜后表面后的折射光线与竖直直线的夹角。 [0103] wherein, y2j Cj4 characterizing point at the centerline of the angle of incidence of the scanning beam of light refracted angle with the vertical surface of the rear straight after the film.

[0104] 用同样的办法可以完成角膜后表面以下的OCT图像的其它列像素的折射校正,最终完成角膜后表面以下的0CT图像的折射校正。 [0104] refractive correction can be done the other columns of pixels below the rear surface of the cornea by OCT images the same way, the final completion of the corrected refractive surface of the cornea below the 0CT image.

[0105] 5)、角膜后表面以下图像的折射率校正 [0105] 5), the refractive index of the surface of the cornea after the correction of the image

[0106] 参考图11,当完成角膜后表面以下图像的折射校正后,接着进行角膜后表面以下图像的折射率校正。 [0106] Referring to FIG 11, after completion of the corneal refractive corrected image below the surface, followed by the corneal surface refractive correction of the image. 如图11所示,眼前节0CT图像角膜后表面以下折射率校正,就是将CJ4 到Jj5 (参考图10)之间的像素压缩成Cj4到Jj6 (图11),压缩的比率为。 11, after the anterior segment of the cornea below the surface of the image 0CT refractive correction is between the pixel CJ4 to Jj5 (refer to FIG. 10) to be compressed into Cj4 JJ6 (FIG. 11), the compression ratio. 根据所得MC:omea 的眼前节OCT图像角膜后表面以下折射率校正后的图像中识别出晶状体前表面轮廓,便能得出准确的晶状体前表面曲率分布。 The resulting MC: omea anterior segment below the surface refractive corrected image identified in the front surface profile retrolental OCT image of the cornea, will be able to arrive at an accurate distribution of the lens front surface curvature.

[0107] 6)、晶状体前表面以下图像的折射校正 [0107] 6), the front refractive surface of the lens corrected image below

[0108] 接着进行晶状体前表面以下折射校正。 [0108] followed by the front surface of the lens refractive correction. 如图12所示,以校正的每一列晶状体前表面像素点为圆心旋转,第j列以Fj6为圆心,旋转角度为(i5j-i6j),将Fj6到晶状体后表面以下的Jj6间的像素值进行旋转,旋转至Fj6到Jj7。 12, each column of pixels to the front surface of the correction lens as the center of rotation, Fj6 j-th column in a circle, the rotation angle (i5j-i6j), the pixel values ​​between Jj6 below the surface of the lens to Fj6 rotation, rotates to Fj6 to Jj7. 其中,Fj6为扫描光束中心线入射至晶状体前表面的入射点,扫描光束中心线在晶状体前表面和晶状体后表面的折射光线为Fj6Ij7。 Wherein, Fj6 center line scanning beam is incident on the incident point of the front surface of the lens, the center line of the scanning beam in the lens front surface and rear surface of the lens is refracted ray Fj6Ij7. i5j为入射角,它表示扫描光束中心线Cj4Fj6和法线Fj607构成的夹角;i6j为折射角,它表示折射光线Fj6Ij7和法线Fj607之间构成的夹角。 i5j angle of incidence, which represents the angle between the scanning beam and the normal to the centerline Cj4Fj6 Fj607 configuration; i6j is the angle of refraction, which represents the angle formed between the refracted light rays and the normal Fj607 of Fj6Ij7.

[0109] 根据公式 [0109] According to the formula

[0110] i5j= 0 3j-y2j可以求出i5j; [0110] i5j = 0 3j-y2j can be obtained i5j;

[0111] 其中,0 3j表示Fj6点处,晶状体前表面的切线与水平线的夹角,由所识别的晶状体前表面曲率分布中得出;Y2j表征Cj4点处扫描光束中心线入射角膜后表面后的折射光线与竖直直线的夹角;0 3j和y2j由前述校正过程中求得,因此根据这两个值求得i5j, After Y2j characterized scanning beam incidence angle at the centerline of the film surface after the point Cj4; [0111] wherein, 0 3j represents at Fj6 point, the horizontal angle between the tangent and the front surface of the lens, the curvature of the front surface of the lens is derived from the distribution of the identified angle of refraction of light and the vertical line; 0 3j and y2j determined from the preceding calibration process and therefore these two values ​​obtained i5j,

[0112] 根据公式 [0112] According to the formula

[0113] nAqueoussin(i5j) =nLenssin(i6j) [0113] nAqueoussin (i5j) = nLenssin (i6j)

[0114] 求得i6j,进而求得旋转角度(i5j_i6j);其中为晶状体折射率。 [0114] determined i6j, then obtain the rotation angle (i5j_i6j); wherein the refractive index of the lens.

[0115] 根据公式 [0115] According to the formula

[0116] y3j=P3j-i6j [0116] y3j = P3j-i6j

[0117] 求得y3j,y3j表示Fj6点处扫描光束中心线入射晶状体前表面后的折射光线Fj6Ij7与竖直直线A0J0的夹角。 [0117] determined y3j, y3j represents the point at Fj6 ray scanning angle and the vertical straight line A0J0 Fj6Ij7 rear refractive surface of the front beam incident on the lens centerline.

[0118] 用同样的办法可以完成晶状体前表面以下的0CT图像的其它列像素的折射校正, 最终完成晶状体前表面以下的0CT图像的折射校正。 [0118] refractive correction can be done the other columns of pixels below the front surface of the lens image 0CT same way, the completion of the final surface of the lens front refraction-corrected image 0CT below.

[0119] 7)、晶状体前表面以下折射率校正 [0119] 7), the front refractive surface of the lens correction

[0120] 如图12所示,眼前节0CT图像晶状体前表面以下折射率校正,以第J列像素为例,就是将Fj6到Jj7之间的像素进行压缩,压缩成图13中的Fj6到Jj8,压缩的比率为根据所得的眼前节OCT图像晶状体前表面以下折射率校正后的图像中识别出晶状^Aqueous 体后表面轮廓,便能得出准确的晶状体后表面曲率分布。 [0120] As shown, the front surface of the lens anterior segment image 0CT 12 corrects the refractive index to Case J-th column pixel, the pixel is between Fj6 Jj7 to compression, compressed to FIG Fj6 to Jj8 13 , the compression ratio of the image recognition in accordance with the refractive index of the front surface of the resultant lens anterior segment OCT image of the surface profile after correction ^ Aqueous crystalline body, the surface curvature will be able to arrive at an accurate distribution of the lens.

[0121] 同样的,用校正晶状体前表面以下的折射和折射率的方法可对晶状体后表面以下的数据就行折射校正和折射率校正。 [0121] Similarly, with the lens front refraction surface correction method and the refractive index of the posterior lens surface data can be below the line refractive correction and refractive correction.

[0122] 8)、晶状体后表面以下折射及折射率的校正 [0122] 8), and a posterior refractive surface of the refractive index correction

[0123] 晶状体后表面以下折射及折射率的校正和晶状体前表面以下折射及折射率的校正方法相同,在此不在累述。 [0123] The following refractive surface and a posterior refractive surface of the refractive index of the correction method and the same pre-correction and the refractive index of the lens, this is not tired.

[0124] 在完成了上述角膜前表面0CT图像,角膜后表面0CT图像、晶状体前表面0CT图像和晶状体后表面0CT图像的校正后,进入眼底视网膜0CT图像的校正。 [0124] After completion of the above-described image 0CT anterior corneal surface 0CT corneal image, the image after the correction surface 0CT 0CT anterior lens surface and the lens image, the correction into the 0CT retinal image. 眼底视网膜0CT图像的校正的方法属于本专利申请文件的核心内容,它是建立在角膜前表面0CT图像,角膜后表面0CT图像、晶状体前表面0CT图像和晶状体后表面0CT图像的校正的基础上进行的。 The method of correcting retinal 0CT image belongs to the core of the present patent application, which is based on the front surface of the cornea 0CT image surface 0CT image of the cornea, based upon the corrected surface 0CT image after 0CT image and lens front surface of the lens on the performed of.

[0125] 参考图20,眼底视网膜0CT图像的校正,包括如下步骤: [0125] Referring to FIG 20, 0CT retinal image correction, comprising the steps of:

[0126] S101 :扫描光束扫描眼前节和眼后节,同时得到经计算机处理的未校正的包含角膜0CT图像、晶状体前表面0CT图像、晶状体后表面0CT图像的人眼前节0CT图像和眼底视网膜0CT图像; [0126] S101: scanning beam scanning anterior segment and posterior segment while obtaining processed by the computer uncorrected, the front surface 0CT lens image, retrolental human face 0CT image anterior segment 0CT image and the retinal 0CT comprising cornea 0CT image image;

[0127] S102:将所述角膜0CT图像、所述晶状体前表面0CT图像和所述晶状体后表面0CT 图像校正还原成真实形态的图像,并从所述图像中得到角膜前表面曲率半径、角膜后表面曲率半径、晶状体前表面曲率半径、晶状体后表面曲率半径、前房深度和晶状体厚度; [0127] S102: The image 0CT the cornea, the front surface of the lens and the image 0CT the rear surface of the lens image correction 0CT reduced to form the image of the real, and the front surface of the corneal radius of curvature obtained from the image, the cornea surface radius of curvature, the radius of curvature of the front surface of the lens, posterior surface radius of curvature, anterior chamber depth and lens thickness;

[0128] S103 :确定出扫描光束经晶状体后表面折射后扫描光束中心线的汇聚点(045), 求出扫描扇形区域圆心位置及扫描角度(u045); [0128] S103: After determining that the scanning beam scans the surface refracted posterior centerline beam convergence point (045), and obtains the center position of the scanning angle of a scanning fan-shaped area (U045);

[0129] S104 :将所述未校正的眼底视网膜0CT图像还原成真实形态的图像。 [0129] S104: the uncorrected image of the fundus retina 0CT reduced to the image of the real morphology.

[0130] 其中,步骤S101和步骤S102已经在前面叙述清楚了。 [0130] wherein, steps S101 and S102 have been described clearly in the front. 步骤S103具体展开描述如下。 DETAILED expand Step S103 described below.

[0131] 参考图14,图15,图18和图19。 [0131] Referring to FIG 14, FIG 15, FIG 18 and FIG 19. 扫描光束经接目物镜206后,如果没有经过人眼,扫描光束中心线汇聚于04点。 After the scanning beam 206 through the eyepiece lens, the eye if they are not, converge at the center line of the scanning beam 04 points. 但扫描光束经角膜前表面时,发生折射,折射后扫描光束中心线汇聚于像点042。 However, when the scanning beam through the cornea front surface, refracted scanning beam refracted image point 042 converge at the center line. 接着扫描光束又经角膜后表面折射,折射后扫描光束中心线汇聚于像点043。 Subsequently the scanning beam and refracted by the corneal surface, the refraction of the scanning beam converges on the center line of the image point 043. 再接着,扫描光束又经晶状体前表面折射,折射后扫描光束中心线汇聚于像点044。 Subsequently, the scanning beam and refracted by the front surface of the lens, is refracted scanning beam image point 044 converge at the center line. 最后,扫描光束又经晶状体后表面折射,折射后扫描光束中心线汇聚于像点045,像点045即为探测光束扫描眼底视网膜0CT的扫描扇形区域的圆心位置。 Finally, the scanning beam after the lens has a refractive surface, the scanning beam is refracted image point 045 converge at the center line, the center dot position of the scanning probe 045 is the fan-beam scanning area of ​​the retina 0CT. 其中像点043处于瞳孔附近,这样有利于扫描光束顺利通过瞳孔,而不被挡光。 Wherein the image point 043 in the vicinity of the pupil, it is a good pupil scanning beam passed, without being light blocking.

[0132] 眼底视网膜的扫描角度u045 =y•u04,其中u04为光束扫描眼后节0CT图像出射时接目物镜206时的扫描角度范围(参考图14)。 Scan angle [0132] retina of u045 = y • u04, u04 wherein the ocular lens is the scanning angle range 206 (see FIG. 14) when the exit section 0CT image beam scanning eye. y为眼前节结构的整体角放大率, y is a whole angular magnification of the anterior segment,

Figure CN104146681BD00141

,它是根据扫描光束依次经角膜前表面、角膜后表面、晶状体前表面和晶状体后表面折射后在所述扫描光束中心线汇聚点汇聚后计算得到。 After the calculated convergence, which is in accordance with the scanning beam successively through the anterior corneal surface, a rear surface of the cornea, the lens front surface and lens rear refractive surface of the scanning beam centerline convergence point. 其中,L045表示扫描光束经晶状体后表面折射后扫描光束中心线的汇聚点到晶状体后表面的距离,L0441表示扫描光束经晶状体前表面折射后扫描光束中心线汇聚点到晶状体后表面的距离,L044表示扫描光束经晶状体前表面折射后扫描光束中心线汇聚点到晶状体前表面的距离,L0431表示扫描光束经角膜后表面折射后扫描光束中心线汇聚点到晶状体前表面的距离,L043表示扫描光束经角膜后表面折射后扫描光束中心线汇聚点到角膜后表面的距离,L0421表示扫描光束经角膜前表面折射后的扫描光束中心线汇聚点到角膜后表面的距离,L042表示扫描光束经角膜前表面时折射后的扫描光束中心线汇聚点到角膜前表面的距离,L04表示扫描光束经接目物镜后扫描光束中心线汇聚点到角膜前表面的距离。 Wherein, L045 represents a scanning beam refracted by the posterior surface of the scanning beam convergence point distance from the center line to the rear surface of the lens, L0441 represents the scanning beam from the rear surface of the scanning beam refracted by the lens anterior to the centerline of the convergence point of the lens rear surface, L044 a scanning light beam refracted by the rear surface of the anterior lens to the scanning beam convergence point centerline distance between the front surface of the lens, L0431 a rear surface of the scanning beam refracted by the cornea after scanning beam convergence point to the centerline distance between the front surface of the lens, L043 represents a scanning beam via after the corneal surface refractive converging scanning beam from the centerline to the point of the corneal surface, L0421 represents the center line of the scanning beam after the scanning beam refracted by the corneal surfaces converging from the point to the corneal surface, L042 represents a scanning beam through the front surface of the cornea the center line of the scanning beam after refraction from the convergence point to the front surface of the cornea, L04 represents the scanning beam through the eyepiece from the objective lens converging the scanning beam centerline point to the front surface of the cornea. L04、 L042、L043、L0421、L044、L0431、L045和L0441通过下面的推导或者计算得到。 L04, L042, L043, L0421, L044, L0431, L045 and L0441 obtained by the following derivation or calculation.

[0133] 参考图4和图14,角膜前表面到接目物镜206的距离LEct〇206 = hCornea+IXDKto206。 [0133] Referring to FIG 4 and FIG 14, the anterior corneal surface to the distance from the eyepiece lens 206 LEct〇206 = hCornea + IXDKto206. 其中hCornea为角膜OCT图像顶端到OCT图像中角膜信号的光程,该值能从角膜0CT图像中获得。 Wherein the top hCornea cornea OCT image to the optical path of the cornea OCT image signal, which value is obtained from the corneal 0CT image. 则04点到角膜前表面的距离L04 =L04t〇206-LEct〇206。 The point 04 to the front surface of the cornea the distance L04 = L04t〇206-LEct〇206.

[0134] 由折射公式,得角膜前表面折射满足公式: [0134] refracted by the formula to obtain the front surface of the corneal refractive satisfies the equation:

[0135] [0135]

Figure CN104146681BD00151

[0136] 其中像点042到角膜前表面的距离为L042,rtoneaFS角膜前表面曲率半径,该值由前述的校正的眼前节0CT图像中获得。 [0136] wherein the image point 042 to the distance between the front surface of the cornea as L042, rtoneaFS anterior corneal curvature radius, the value obtained by the aforementioned the anterior segment of the image correction 0CT. 11_为空气折射率,n__为角膜折射率,n_和n__ 均为已知值。 11_ is a refractive index of air, n__ corneal refractive index, n_ n__ and are known values. 因此,在求出L042后而能得出像点042的位置。 Therefore, after obtaining L042 can come and position of the pixel 042.

[0137] 角膜后表面折射满足: [0137] After corneal surface refractive satisfied:

[0138] [0138]

Figure CN104146681BD00152

[0139] 其中物点042点到角膜后表面的距离为L0421,L0421 =L042-HouCornea,其中角膜厚度HouCornea由前述的校正后的眼前节OCT图像中获得;rto_B为角膜后表面曲率半径,该值由前述的校正后的眼前节0CT图像中获得;nAq_us为眼前节房水折射率;像点043 点到角膜后表面的距离L043因此可以求得,从而能得出像点043的位置。 [0139] wherein the object point 042 point to the corneal surface distance is L0421, L0421 = L042-HouCornea, wherein the corneal thickness HouCornea obtained from the anterior segment OCT image aforementioned correction; rto_B corneal radius of curvature of the rear surface, the value obtained from the anterior segment image 0CT aforementioned correction; nAq_us anterior segment of the refractive index of aqueous humor; point to the image point 043 from the rear surface of the cornea can be determined L043, so that it can obtain the position of the image point 043.

[0140] 晶状体肖U表面折射满足: [0140] Shore lens refracting surface satisfies U:

[0141] [0141]

Figure CN104146681BD00153

,其中物点043点到晶状体前表面的距离为L0431, L0431 =L043_HouAqueous,其中角膜后表面到晶状体前表面的前房深度HouAqueous能由前述的校正的眼前节0CT图像中获得;L043前面已经求得;r^sF为晶状体前表面曲率半径, 该值由前述的校正的眼前节0CT图像中获得;化_为晶状体折射率。 Wherein the distance from the object point 043 point to the front surface of the lens is L0431, L0431 = L043_HouAqueous, wherein the rear surface of the cornea into the anterior chamber depth HouAqueous front surface of the lens can be obtained from the anterior segment image correction in 0CT; L043 previously determined ; r ^ sF is the radius of curvature of the front surface of the lens, the value is obtained from the anterior segment image correction in 0CT; _ of the refractive index of the lens. 因此像点044点到晶状体前表面的距离L044可求出,从而能得出044点的位置。 Thus the image distance from point 044 to point the front surface of the lens L044 can be obtained, so that it can obtain the position of point 044.

[0142] 晶状体后表面折射满足: [0142] posterior refractive surface satisfies:

[0143] [0143]

Figure CN104146681BD00154

[0144] 其中物点044点到晶状体后表面的距离为L0441,L0441 =L044-H〇uLens,晶状体厚度HouLens能由前述的校正的眼前节0CT图像中获得;nVlt_us为玻璃体的折射率;rtensB 为晶状体后表面曲率半径,该值由前述的校正的眼前节0CT图像中获得,从而能得出045 点的位置,即知道接目物镜206到045点的距离,进一步求得像点045点到晶状体后表面的距离L045,从而亦能得到扫描光束中心线最终汇聚045点与视网膜0CT图像顶端所对应的空间位置RDK2的距离L045t〇RDK2 (参考图15和图19)。 [0144] wherein the object point distance from the point 044 to the rear surface of the lens is L0441, L0441 = L044-H〇uLens, lens thickness can be obtained by the aforementioned HouLens anterior segment image correction in 0CT; nVlt_us is the refractive index of the glass body; rtensB is posterior surface radius of curvature, the value obtained by the aforementioned image correction 0CT front section, so that the position of 045 can draw point, i.e., the objective lens from the ocular know 206-045 point, the image point is obtained further 045 points to the lens distance L045 rear surface to the center line of the scanning beam can also give the final convergence point distance L045t〇RDK2 045 0CT retinal image corresponding to the spatial position of the top RDK2 (refer to FIG. 15 and FIG. 19). 因此眼前节结构的整体角放大率 Therefore, the overall magnification of anterior segment angle

Figure CN104146681BD00155

可求。 Rectifiable. 则眼底视网膜的扫描角度u045 =y*1104也可以求出。 Retinal scan angle of the u045 = y * 1104 may be obtained. 其中u04为光束扫描眼后节0CT图像出射时接目物镜206时的扫描角度范围。 U04 wherein the ocular lens is the scanning angle range of the section 206 at the time of image 0CT beam scanning after exiting the eye.

[0145] 参考图16,从上分析知,眼后节0CT扫描眼底视网膜时,是以045为圆心,以u045 为扫描角度范围进行扫描,即扫描的是一扇形区域。 [0145] Referring to FIG 16, known from the analysis, the posterior section when 0CT retina scan, as the center is 045, u045 to scanning angle range scans, i.e. scan a sector region. 但原始所得的眼底0CT图像是矩形形状,因而需要对眼底视网膜0CT图像进行校正。 But the original fundus 0CT resulting image is rectangular in shape, therefore the need for 0CT retinal image is corrected.

[0146] 步骤S104:将所述未校正的眼底视网膜OCT图像还原成真实形态的图像。 [0146] Step S104: the uncorrected image is reduced to retinal OCT image of the real morphology.

[0147] 参考图21,具体地,步骤S104分为S201和S202: [0147] Referring to FIG 21, in particular, it divided into steps S201 and S104 S202:

[0148]S201:将所述未校正的眼底视网膜0CT图像划分为(2m+l)列像素; [0148] S201: the uncorrected image into a retinal 0CT (2m + l) column of pixels;

[0149] 具体地,参考图16,由于未校正的眼底视网膜0CT图像为矩形图像,将该矩形图像划分为(2m+l)列。 [0149] In particular, with reference to FIG. 16, since the uncorrected 0CT retinal image is a rectangular image, the image is divided into rectangles (2m + l) columns.

[0150]S202:根据扫描角度(u045),将所述(2m+l)列像素分别进行平移和旋转,得到校正后的眼底视网膜0CT图像。 [0150] S202: The scanning angle (U045), the (2m + l) columns of pixels respectively translated and rotated to obtain retinal 0CT corrected image.

[0151] 对于步骤S202,参考图24。 [0151] For the step S202, with reference to FIG 24. 可以将其分为S301-S306共6步步骤。 Which it can be divided into 6 steps S301-S306 step.

[0152]S301 :选取所述(2m+l)列的像素的任意第K列像素,确定其旋转角度 [0152] S301: Select the (2m + l) any column of pixels in the pixel column of K, which determines the angle of rotation

Figure CN104146681BD00161

[0153] S302 :求出扫描光束经晶状体后表面折射后扫描光束中心线的汇聚点(045)与视网膜0CT图像顶端所对应的空间位置RDK2的距离L045toRDK2 ; [0153] S302: obtaining the lens surface of the scanning beam after the refraction point of convergence of the scanning beam centerline post (045) and the top of the image from the retinal 0CT corresponding spatial position of RDK2 L045toRDK2;

[0154] S303 :求出未校正的眼底视网膜OCT图像的第K列像素的顶端的第一像素点在校正后的眼底视网膜0CT图像中所处的第一位置的坐标; [0154] S303: a first position of the first pixel coordinate of the top point of the uncorrected determined OCT image of the fundus retina K column of pixels located in the image of the fundus retina corrected 0CT;

[0155] S304 :先将所述未校正的第K列像素整列平移,并使所述第一像素点处于所述第一位置,然后以所述第一位置为第一圆心,以所述角度uk旋转经过平移后的第K列像素,完成所述第K列像素的校正;或者先以所述第一像素点在未校正的眼底视网膜0CT图像的所在位置为第二圆心,将所述第K列像素以角度uk旋转,然后将经过旋转后的第K列像素整列平移,并使所述第一像素点处于所述第一位置,完成所述第K列像素的校正; [0155] S304: first the uncorrected K-th column of pixels aligned translation, and the first pixel point in the first position, then at the first position of the first circle, at said angle uk rotated through K-th column of pixels of the shifted, the correction is completed K-th column of pixels; location or prior to the first pixel in the uncorrected image of the fundus retina 0CT a second center, the first K uk column of pixels at an angle of rotation, and translation of the columns of pixels aligned after rotation through the first K, and the first pixel point in the first position, the first K columns of pixels to complete the correction;

[0156]S305:用和校正第K列像素相同办法校正其余2m列像素,将所述未校正的眼底视网膜0CT图像还原成其真实形态的图像。 [0156] S305: the correction by the same way and the remaining K-th column pixel correction 2m columns of pixels, the uncorrected image 0CT retinal image is reduced to its true form.

[0157] 对于步骤S301-S305,结合图16、图17、图22和图24具体展开描述。 [0157] For the step S301-S305, in conjunction with FIGS. 16, 17, 22 and 24 to expand specifically described. 参考图16, 图16是经计算机处理得到的未校正的矩形眼底视网膜0CT图像,需要将其校正还原成图17 所示的校正后的扇形眼底视网膜0CT图像。 Referring to FIG 16, FIG 16 is a rectangular uncorrected 0CT retinal image obtained by computer processing, the correction needs to be reduced to the fan 0CT retina corrected image 17 shown in FIG. 将图16中的像素划分成(2m+l)列,各列像素均需要校正还原。 The pixel 16 is divided into (2m + l) columns, each column of pixels are necessary to correct the reduction. 以图16中的第K列像素校正为例,其实质是将第k列的Qk到Tk之间的全部像素校正还原成图17中的Qk2到Tk2所示位置。 In Figure 16, an example of a correction K columns of pixels, which is the essence of all the pixels between the first column k Tk Qk to restore the correct position to Qk2 Tk2 shown in FIG. 17. 具体地,图16中的第K列像素校正还原过程如下:首先求出图16中的第K列像素校正还原成图17中的相应位置时的旋转角度uk,uk可以根据公式 In particular, FIG. 16 K-th column pixel correction reduction process is as follows: First, to obtain the rotation angle FIG. 16 K-th column of pixels corresponding to the correction position is reduced to FIG. 17 uk, uk using the formula

Figure CN104146681BD00162

求得,而扫描角度u045在前面已经求出,因此旋转角度uk可求;接着求出扫描光束中心线最终汇聚045点与视网膜0CT图像顶端所对应的空间位置RDK2的距离L045t〇RDK2,该值在前面的叙述中已经求出。 Obtained, while the scanning angle u045 been determined earlier, so that the rotation angle can be evaluated uk; Subsequently the scanning beam is obtained from the centerline of the final convergence point 045 and the spatial position RDK2 0CT retinal image corresponding to the top L045t〇RDK2, the value in the foregoing description has been obtained. 要校正还原第K列像素,需要将其整列经过旋转平移或者平移旋转至图17中的相应位置,因此需要求出第K列像素在图17中的相应位置坐标,但是,由于第K列像素是整列一起旋转平移或者平移旋转, 只需要求出图16中的第K列像素顶端的第一像素点QK在图17中的第一位置QK2的具体位置,第K列的其余剩下的像素点跟着第一像素点旋转平移或者平移旋转即可。 To correct restore the first K columns of pixels, need to be aligned through rotation and translation or translation rotated to a corresponding position in FIG. 17, it is necessary to obtain respective positional coordinates of the K-th column of pixels in FIG. 17, however, since the K-th column of pixels is aligned with the translation or rotation of the rotary pan, the only requirement of the first pixel QK2 QK top of column K in FIG. 16 in the first pixel position in the specific location in FIG. 17, the rest of the remaining columns of pixels K point followed by translation or rotation of the first pixel to translate rotation. 因此,需要求出图17中的第一位置QK2的具体坐标。 Therefore, in FIG determined QK2 17 a first specific coordinate position. 第一位置QK2的具体坐标的求出方法见图24 : 定义图16中如下坐标:第0列像素顶端的第二像素点Q0的第二位置坐标(0, 0)、045坐标(0, -L045toRDK2),以045为中心,L045toRDK2为半径,uk为旋转角度,将第二位置(0,0) 旋转至图17中的第一位置QK2的坐标(XI,Y1),根据计算得出 The method of obtaining the coordinates of a first position QK2 particular in Figure 24: Figure 16 is defined in the following coordinates: a second pixel in the second position coordinates (0, 0) of the 0th column to the top of the pixel Q0, 045 coordinates (0, - L045toRDK2), centered at 045, L045toRDK2 radius, UK rotation angle, the second position (0,0) is rotated to a first position 17 in FIG QK2 coordinates (XI, Y1), obtained according to the calculation

[0158]XI=L045toRDK2*sin(uk),Yl= -L045toRDK2+L045toRDK2*cos(uk)= L045toRDK2*(cos(uk)-l),将成二的值代入XI和Y1,最终求得QK2的坐标。 [0158] XI = L045toRDK2 * sin (uk), Yl = -L045toRDK2 + L045toRDK2 * cos (uk) = L045toRDK2 * (cos (uk) -l), will become the two values ​​into the XI and Y1, finally get the coordinates QK2 . 2浓+ 1 QK2的坐标求出后,以图16中的第一像素点QK为基准,带动QK至TK的第K列像素先平移至图17中的虚线位置,并使第一像素点QK落入第一位置QK2,然后以第一位置QK2为第一圆心,将已经平移的第K列像素以旋转角uk旋转,完成第K列像素的校正还原,这就是以先平移后旋转的方式校正还原第K列像素。 After concentration of 2 + 1 QK2 coordinates are obtained, a first pixel QK FIG. 16 as a reference, QK led to K-th column of the first pixel level TK broken line position in FIG. 17 moves, and the first pixel QK QK2 position falls within the first, then the first location is a first QK2 center, which has been translated in the first column of pixels K uk rotation angle rotation, to complete the reduction correction K-th column of pixels, which is after the first translation rotatably reducing K-th column pixel correction. 还有一种是先旋转后平移第K列像素实现校正,该方法具体如下:在QK2的坐标求出后,以图16中的第一像素点QK所在的位置为第二圆心, 带动QK至TK的第K列像素以旋转角度uk旋转,然后将旋转后的第K列像素平移,直至第一像素点QK落入QK2的坐标(XI,Y1),这样也可以实现第K列像素的校正还原。 There is a rotation to the latter a translation correction K-th column of pixels to achieve the method as follows: after obtaining QK2 coordinate position of a first pixel of FIG. 16 where a second center QK, QK to drive TK the first column of pixels K uk rotation angle of the rotation, then after rotation of the K-th column pixel shift, until the coordinates of a first pixel falls QK2 of QK (XI, Y1), so that the correction can be realized reduction of the K-th column of pixels . 因此,先平移后旋转或者先旋转后平移第K列像素的校正结果是一样的,也就是说校正后的第K列像素在校正后的眼底视网膜0CT图像中所处的位置是一样的。 Thus, after the first post-translational or rotational correction result of the first rotational translation K column of pixels it is the same, that is to say the position of the K-th column of pixels located in corrected 0CT retina corrected image is the same.

[0159] 在完成上述第K列像素的校正还原后,用同样的办法校正还原图16中的剩余的2m列像素,最终将图16中矩形眼底视网膜0CT图像校正还原成图17中反映眼底视网膜真实形状的图像。 [0159] After completion of the correction to restore the first K columns of pixels, in the same way in the 16 remaining 2m columns of pixel correction reduction FIG eventually 16 rectangular retinal 0CT image correction is reduced to 17 reflected retinal images of the real shape. 因此,从还原的眼底视网膜0CT图像中能够精确的得出眼底视网膜的曲率分布图。 Thus, the curvature can be accurately derived from the profile of retinal retinal image reproduction in 0CT. 需要说明的是,图16中的Qk到Tk的距离等于图17中Qk2到Tk2的距离,都等于0CT系统的探测深度,也就是说,每一列像素的高度在校正前后是不变化的。 Incidentally, FIG. 16 Qk Tk is equal to the distance 17 in FIG Qk2 the distance Tk2 are equal to the depth of 0CT system, i.e., the height of each column of pixels before and after the correction is not changed.

[0160] 参考图23,作为一种特例,测量被测者人眼时,系统可以通过移动固视标501,让被测人眼固视,使得被测人眼光轴与系统光路的主光轴重合。 [0160] Referring to FIG 23, as a special case, when measuring the subject eye, the system by moving the fixation index 501, so that the tested eye fixation, so that the main optical axis and the axis of the human eye test system optical path coincide. 这样设置后,在前面的0CT图像校正过程中,所有0CT图像的第零列像素无需校正,因为此时第零列像素就是指扫描光束中心线沿系统主光轴出射时得到的列像素。 This setting, in front of the 0CT image correction process, all pixels in column zero 0CT image without correction, because the zeroth column of the pixel refers to a pixel scan sequence obtained when the main optical axis of the outgoing beam along the centerline of the system.

[0161] 以上所述仅为本发明的较佳实施例而已,并不用以限制本发明,凡在本发明的精神和原则之内所作的任何修改、等同替换和改进等,均应包含在本发明的保护范围之内。 [0161] The foregoing is only preferred embodiments of the present invention but are not intended to limit the present invention, any modifications within the spirit and principle of the present invention, equivalent substitutions and improvements should be included in the present within the scope of the invention.

Claims (10)

1. 一种眼底视网膜OCT图像校正方法,其特征在于,包括如下步骤: 扫描光束扫描眼前节和眼后节,同时得到经计算机处理的未校正的包含角膜OCT图像、晶状体前表面OCT图像、晶状体后表面OCT图像的人眼前节OCT图像和眼底视网膜OCT 图像; 将所述角膜OCT图像、所述晶状体前表面OCT图像和所述晶状体后表面OCT图像校正还原成真实形态的眼前节OCT图像,并从所述校正后的眼前节OCT图像中得到角膜前表面曲率半径、角膜后表面曲率半径、晶状体前表面曲率半径和晶状体后表面曲率半径、角膜厚度、前房深度和晶状体厚度; 确定出扫描光束经晶状体后表面折射后扫描光束中心线的汇聚点(045),求出扫描扇形区域圆心位置及扫描角度(U045); 将所述未校正的眼底视网膜OCT图像还原成真实形态的图像。 A retinal OCT image correction method comprising the steps of: scanning beam scanning anterior segment and the posterior segment, while processed by the computer to obtain uncorrected OCT image comprising the cornea, the front surface of the OCT image of the lens, the lens OCT images of the rear surface of human anterior segment OCT OCT image and the retinal image; OCT image of the cornea, the front surface of the lens of the OCT image and the rear surface of the lens correction OCT image is reduced to form a real image of the anterior segment OCT, and obtained from the radius of curvature of the anterior corneal anterior segment OCT image after the correction, the radius of curvature of the corneal surface, the radius of curvature of the lens front surface and the rear surface of the lens radius of curvature, corneal thickness, anterior chamber depth and lens thickness; it is determined that the scanning beam after the lens rear refractive surface of the scanning beam convergence point of the center line (045) to obtain the center position of the scan and the sector scan angle region (U045); the uncorrected image is reduced to retinal OCT image of the real morphology.
2. 如权利要求1所述的眼底视网膜OCT图像校正方法,其特征在于:所述扫描角度(u045)是根据公式u045 = γ · u04 求得; 其中,γ表示眼前节的整体角放大率,根据扫描光束依次经角膜前表面、角膜后表面、 晶状体前表面和晶状体后表面折射后在所述扫描光束中心线汇聚点汇聚后计算得到;U04 表示扫描光束扫描眼后节OCT图像时出射接目物镜时的扫描角度。 2. The retinal OCT image correction method according to claim 1, characterized in that: said scan angle (U045) is calculated according to the formula u045 = γ · u04; wherein, overall gamma] represents the angular magnification of the anterior segment, the scanning beam successively through the front surface of the cornea, the back surface, a front surface and a posterior refractive surface of the lens in the converging scanning beam center line calculated after the convergence point; U04 when exiting the ocular segment OCT image showing the scanning beam scans the eye when the scanning angle of the objective lens.
3. 如权利要求1所述的眼底视网膜OCT图像校正方法,其特征在于,将所述未校正的眼底视网膜OCT图像还原成真实形态的图像,具体包括: 将所述未校正的眼底视网膜OCT图像划分为2m+l列像素; 根据扫描角度(u045),将所述2m+l列像素分别进行平移旋转或者旋转平移,得到校正后的眼底视网膜OCT图像。 3. The OCT retinal image correction method according to claim 1, characterized in that the uncorrected retinal OCT image is reduced to form a real image, comprises: the retinal uncorrected OCT image divided into 2m + l columns of pixels; the scan angle (U045), the 2m + l columns of pixels in translation or rotation of the rotary pan, retinal OCT image obtained after the correction.
4. 如权利要求3所述的眼底视网膜OCT图像校正方法,其特征在于:所述根据求得的扫描角度(u045),将所述2m+l列像素分别进行平移旋转或者旋转平移的具体步骤包括: 选取所述2m+l列的像素的任意第k列像素,确定其旋转角度 4. The retinal OCT image correction method according to claim 3, wherein: said scanning angle according to the obtained (U045), the column of pixels 2m + l are translated specific steps will be rotated or rotational translation comprising: selecting any of the 2m + l k-th column of pixels of the pixel column, which determines the angle of rotation
Figure CN104146681BC00021
求出所述扫描光束经晶状体后表面折射后扫描光束中心线的汇聚点(045)到所述未校正的眼底视网膜OCT图像顶端所对应的空间位置RDK2的距离L045toRDK2 ; 求出未校正的眼底视网膜OCT图像的第k列像素的顶端的第一像素点在校正后的眼底视网膜OCT图像中所处的第一位置的坐标; 先将所述未校正的第k列像素整列平移,并使所述第一像素点处于所述第一位置,然后以所述第一位置为第一圆心,以所述角度uk旋转经过平移后的第k列像素,完成所述第k列像素的校正;或者先以所述第一像素点在未校正的眼底视网膜OCT图像的所在位置为第二圆心,将所述第k列像素以角度uk旋转,然后将经过旋转后的第k列像素整列平移,并使所述第一像素点处于所述第一位置,完成所述第k列像素的校正; 用和校正第k列像素相同办法校正其余2m列像素,将所述未校正的眼底视网膜OCT图 Obtaining the scanning spot of the scanning beam converging centerline rear surface of the beam refracted by the lens (045) to the uncorrected distance retinal OCT image corresponding to the spatial position of the top of RDK2 L045toRDK2; retinal determined uncorrected a first pixel at the top of the k-th column of pixels located in the OCT images OCT retina corrected image coordinates of a first position; the first uncorrected k-th column of pixels aligned translation, and the the first pixel in the first position and a first position at the first center, uk rotated through an angle to the k-th column of pixels of the shifted, the correction is the k-th column of pixels; or first a position where the OCT image of the fundus retina to the first pixel point in the uncorrected second center, the k-th column of pixels uk rotation angle, and then translating the row of pixels aligned after rotation through the first k, and the first pixel point in the first position, completing the correction of the k-th column of pixels; and correcting the same way with the k-th column pixel correction 2m remaining columns of pixels, the uncorrected FIG retinal OCT 像还原成其真实形态的图像。 Like the image is reduced to its true form.
5. 如权利要求2所述的眼底视网膜OCT图像校正方法,其特征在于:所述眼前节的整体角放大率γ的计算公式为 5. retinal OCT image correction method according to claim 2, wherein: the anterior segment of the overall angle magnification γ is calculated
Figure CN104146681BC00031
其中,L045表示扫描光束经晶状体后表面折射后扫描光束中心线的汇聚点到晶状体后表面的距离,L0441表示扫描光束经晶状体前表面折射后扫描光束中心线汇聚点到晶状体后表面的距离,L044表示扫描光束经晶状体前表面折射后扫描光束中心线汇聚点到晶状体前表面的距离,L0431表示扫描光束经角膜后表面折射后扫描光束中心线汇聚点到晶状体前表面的距离,L043表示扫描光束经角膜后表面折射后扫描光束中心线汇聚点到角膜后表面的距离,L0421表示扫描光束经角膜前表面折射后的扫描光束中心线汇聚点到角膜后表面的距离,L042表示扫描光束经角膜前表面时折射后的扫描光束中心线汇聚点到角膜前表面的距离,L04表示扫描光束经接目物镜后扫描光束中心线汇聚点到角膜前表面的距离。 Wherein, L045 represents a scanning beam refracted by the posterior surface of the scanning beam convergence point distance from the center line to the rear surface of the lens, L0441 represents the scanning beam from the rear surface of the scanning beam refracted by the lens anterior to the centerline of the convergence point of the lens rear surface, L044 a scanning light beam refracted by the rear surface of the anterior lens to the scanning beam convergence point centerline distance between the front surface of the lens, L0431 a rear surface of the scanning beam refracted by the cornea after scanning beam convergence point to the centerline distance between the front surface of the lens, L043 represents a scanning beam via after the corneal surface refractive converging scanning beam from the centerline to the point of the corneal surface, L0421 represents the center line of the scanning beam after the scanning beam refracted by the corneal surfaces converging from the point to the corneal surface, L042 represents a scanning beam through the front surface of the cornea the center line of the scanning beam after refraction from the convergence point to the front surface of the cornea, L04 represents the scanning beam through the eyepiece from the objective lens converging the scanning beam centerline point to the front surface of the cornea.
6. 如权利要求5所述的眼底视网膜OCT图像校正方法,其特征在于:所述扫描光束经角膜前表面时折射后的扫描光束中心线汇聚点是根据公式 6. The retinal OCT image correction method according to claim 5, wherein: said scanning beam scans the center line of the rear surface of the convergence point when the cornea is refracted beam premenstrual according to the formula
Figure CN104146681BC00032
其中:11^_为角膜折射率,n ^表示空气折射率;r 为角膜前表面曲率半径,r to_F 由校正后的眼前节OCT图像获得。 Wherein: the refractive index of the cornea 11 _ ^, n ^ represents the refractive index of air; r is the radius of the anterior corneal surface curvature, r to_F anterior segment OCT image obtained from the corrected.
7. 如权利要求5所述的眼底视网膜OCT图像校正方法,其特征在于:所述扫描光束经角膜后表面折射后扫描光束中心线汇聚点是根据公式 7. OCT retinal image correction method according to claim 5, wherein: said scanning light beams after being refracted by the rear surface of the cornea center line scanning beam convergence point according to the formula
Figure CN104146681BC00033
其中:1^_为角膜折射率,n Aq_us表示眼前节房水折射率,r eOT_B为角膜后表面曲率半径,由校正后的眼前节OCT图像中获得;所述扫描光束经角膜后表面折射后扫描光束中心线汇聚点处于瞳孔附近。 Wherein: 1 ^ _ corneal refractive index, n Aq_us represents the refractive index of the anterior segment of aqueous humor, r eOT_B corneal surface curvature radius, from the anterior segment OCT image obtained after the correction; said scanning beam refracted by the cornea surface scanning beam center line in the vicinity of the convergence point of the pupil.
8. 如权利要求5所述的眼底视网膜OCT图像校正方法,其特征在于:所述扫描光束经晶状体前表面折射后扫描光束中心线汇聚点是根据公式: 8. retinal OCT image correction method according to claim 5, wherein: said scanning beam refracted by the front surface of the lens centerline scanning beam convergence point according to the formula:
Figure CN104146681BC00034
其中,!![^表不晶状体折射率;n 眼如节房水折射率;rLensF1为晶状体如表面曲率半径,4nsF由校正后的眼前节OCT图像中获得。 Wherein !! [^ a refractive index of the lens table does; n-ocular aqueous humor, such as the refractive index of the section; rLensF1 such as surface radius of curvature, 4nsF anterior segment OCT image obtained from the correction of the lens.
9. 如权利要求5所述的眼底视网膜OCT图像校正方法,其特征在于:所述扫描光束经晶状体后表面折射扫描光束中心线的汇聚点根据公式 9. The retinal OCT image correction method according to claim 5, wherein: said scanning surface refracting point of convergence of the scanning beam after the beam passing through the centerline of the lens according to the formula
Figure CN104146681BC00035
其中,nVltra_为玻璃体的折射率;n Uns表示晶状体折射率;r 晶状体后表面曲率半径,rUnsB由校正后的眼前节OCT图像中获得。 Wherein, nVltra_ is the refractive index of the glass body; n Uns represents the refractive index of the lens; the r radius of curvature of the lens surface, rUnsB obtained by the OCT anterior eye segment image after correction.
10. 如权利要求1-9中任一项所述的眼底视网膜OCT图像校正方法,其特征在于:所述未校正的眼前节OCT图像由一张OCT图像构成或者由二至三张OCT图像合成;若由一张OCT 图像构成,则该张OCT图像包含角膜OCT图像、晶状体前表面OCT图像、晶状体后表面OCT图像;若由两张OCT图像合成,则第一张为角膜OCT图像和晶状体前表面OCT图像,第二张为晶状体后表面OCT图像或者第一张为角膜OCT图像,第二张为晶状体前表面OCT图像和晶状体后表面OCT图像;若由三张OCT图像合成,则所述三张OCT图像分别为角膜OCT图像、 晶状体前表面OCT图像和晶状体后表面OCT图像;所述未校正的眼前节OCT图像的张数由系统探测深度决定。 10. The retinal 1-9 OCT image correction method according to any one of the preceding claims, characterized in that: the uncorrected image of an anterior segment OCT OCT image composed of two to three or OCT image compositing ; if the image constituted an OCT, the OCT image sheet comprises OCT corneal image, the front surface of the lens OCT image, the rear surface of the lens OCT image; if the two front OCT image synthesis, the first lens is the cornea and OCT image OCT image surface, the second surface of the first image or OCT OCT corneal lens image, the second image lens surface OCT OCT image and the front surface of the lens; if the three OCT image synthesis, is the three OCT images were Zhang OCT image of the cornea, the front surface of the OCT image and the OCT image posterior surface of the lens; the number of the uncorrected anterior segment OCT images determined by the depth detection system.
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