CN104307583A - Chip-scale gas-liquid separator and control system thereof - Google Patents
Chip-scale gas-liquid separator and control system thereof Download PDFInfo
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Abstract
The invention relates to a chip-scale gas-liquid separator and a control system thereof. The chip-scale gas-liquid separator comprises a chip-scale gas-liquid separator and assembly unit, a control interface circuit and a chip-scale gas-liquid separator control system based on FPGA+DSP (field programmable gate array and digital signal processor), wherein the chip-scale gas-liquid separator and assembly unit is used for micro-mixing, micro-reaction and gas-liquid separation of a liquid-liquid fluid system under the micro-volume condition; the interface circuit is connected between the chip-scale gas-liquid separator control system and the chip-scale gas-liquid separator and assembly unit; the chip-scale gas-liquid separator control system is used for generating various control signals required for effective separation of the chip-scale gas-liquid separator and monitoring a gas-liquid interval form in a micro-reaction channel in real time to achieve the best gas-liquid separation effect. The chip-scale gas-liquid separator and the control system thereof provided by the invention can be used for effective mixing and reaction of reaction liquid in a microfluidic chip-atomic fluorescence online combined system for trace element detection, gas-state product enrichment and gas-liquid effective separation.
Description
Technical field
The invention belongs to micro-electro-mechanical systems to unify microring array and embedded system field, relate to a kind of chip-scale gas-liquid separator and control system thereof.
Background technology
The micro-fluidic chip developed based on the Micrometer-Nanometer Processing Technology of MEMS (MEMS) to obtain in fields such as bioanalysis, food analysis, chemical analysis and environmental analyses and pays close attention to widely because it has high integration, the advantage such as efficient, quick, micro-, one of study frontier focus having become analysis science.As micro-full analytical system (Miniaturized Total Analysis Systems, uTAS) a kind of core technology, micro-fluidic chip oneself to detect for various analysis through successfully combining with various analysis (as Mass Spectrometer Method, Electrochemical Detection and optical detection etc.).
In recent years, the on-line coupling technical research being directed to micro-fluidic chip mainly concentrates on the interface of micro-fluidic device and pertinent instruments.As micro-fluidic device and mass spectrograph (mass spectrometry, MS) interface between has electron spray (Electrospray ionization, ESI), substance assistant laser desorpted ionized (Matrix-Assisted Laser Desorption Ionization, MALDI) etc. is multi-form.Still there is many areas for improvement at present.Devices successfully carrying out complicated micro-fluidic operation as many in present stage all adopt glass as material, are difficult to the ESI nozzle processing high integration easily, and multichannel miniature ESI nozzle can only be processed at silicon or plastics by micro-fabrication technology, Nankai University chemistry institute's analysis science research center Li Feng etc. selects XGY-1011A type non-dispersive atomic fluorescence photometer, for chip integrated feature and be convenient to coupling, abandon the sampling system that XGY-1011A is original, by directly etched a replenisher passage on chip, optimize chip design, chip-atomic fluorescence interface, gas-liquid separator and atomizer etc., successfully eliminate and introduce fluid (replenisher HCl, reducing agent KBH4 and argon gas) adverse effect that chip electrophoresis is separated, do not needing the coupling realizing minor effect genes-atomic fluorescence detection under the prerequisite that apparatus structure is changed, thisly only between micro-fluidic device and detecting instrument, increase interface unit, very difficult realization truly realizes " chip lab ".
For this reason, based on microfluidic chip technology, carrying out the research of on-line coupling technology on chip electrophoresis separation, chip in a deep going way, being of great significance at the application tool in the fields such as biology, chemical analysis for studying microfluidic chip technology further.As realizing integrated key factor---the chip-scale gas-liquid separation realizing trace element (as selenium) and detect fast of micro-fluidic chip-atomic fluorescent on-line combined, directly decide micro-fluidic chip-atomic fluorescent on-line combined with integrated " microminiaturization " that whether can realize truly.At present, the research work carrying out gas-liquid separation in micro-fluidic chip is less, and its main cause is carried out gas-liquid and handled more difficult under being micro-volume condition, and the compressibility of gas makes the flow velocity of gas unstable.In addition, little 2 to 3 orders of magnitude of ratio of viscosities liquid of gas, also have influence on the stability of flowing.However, the gas-liquid in chip microbody system is mixed also also has many advantages.Under system condition as micro-in chip, gas-liquid Contact face mixes higher than conventional system gas-liquid, accelerates the speed of vapor liquid equilibrium, the speed of chemical reaction.
Therefore, for meeting micro-fluidic chip---atomic fluorescent on-line combined detection needs, agree with the feature of micro-full analytical system requirement automation, integrated, portability, how to design applicable micro-fluidic chip---atomic fluorescent on-line combined chip-scale gas-liquid separator and control system thereof are directly connected to micro-fluidic chip---can atomic fluorescent on-line combined use truly realize integrated.
Summary of the invention
In view of this, the object of the present invention is to provide a kind of chip-scale gas-liquid separator and control system thereof, efficiently solve based on micro-fluidic chip---the atomic fluorescent on-line combined key technical problem such as effective separation, the accurate control of flow rate of carrier gas, the accurate control of reactant liquor flow velocity by the required gas-liquid of integrated detection trace element (as selenium).
For achieving the above object, the invention provides following technical scheme:
Chip-scale gas-liquid separator provided by the invention and control system thereof, comprise chip-scale gas-liquid separator and assembly, control interface and the chip-scale gas-liquid separator control system based on FPGA+DSP;
Described chip-scale gas-liquid separator and assembly thereof are for realizing the liquid-liquid fluid system microring array under micro-volume condition, micro-reaction, gas-liquid separation, gas-liquid interval form (as bubble flow, interval stream, circulation) and gas-liquid separation effect in the micro-reaction raceway groove of Real-Time Monitoring annular, so that control system dynamic conditioning flow rate of carrier gas and reaction mixture flow velocity, to realize best gas-liquid separation effect;
Described interface circuit is connected between chip-scale gas-liquid separator control system and chip-scale gas-liquid separator and assembly thereof, for the driving to micro pump and micro-valve, to realize mixed reaction solution flow control; For the driving to micro-air valve, liquid valve, realize that Air-liquid pipeline controls in order, the control of flow rate of carrier gas; For the driving to micro-suction pump, be effectively separated to realize gas-liquid, ensure reactant mixture Ngatively pressurized sampling; For the control to high definition OEM camera module, to realize initialization, the high-speed image sampling of high definition OEM camera module;
Described chip-scale gas-liquid separator control system, adopt FPGA+DSP framework mode, gas-liquid interval form in required various control signals, the micro-reaction raceway groove of Real-Time Monitoring (as bubble flow, interval stream, circulation) is effectively separated for generation of chip-scale gas-liquid separator, dynamic conditioning flow rate of carrier gas and reaction mixture flow velocity, to realize best gas-liquid separation effect.
Further, described chip-scale gas-liquid separator is by dimethyl silicone polymer (polydimethylsiloxane, PDMS) and transparent slide be prepared from, comprise microring array unit, carrier gas access unit, annular micro-reaction member, gas-liquid separation unit and gas-liquid interval form monitoring means;
Described microring array unit, also comprises the micro-liquid storage tank of reducing agent/reagent/specimen; Microring array unit for realizing effective mixing of reducing agent, reagent, sample, or contains gaseous mixture enrichment, to improve gaseous reactant to be measured (as SeH for multichannel through reacted
2) content; The wherein micro-liquid storage tank of reducing agent/reagent/specimen, for realizing reducing agent, reaction reagent, sample solution injection, storage;
Described carrier gas access unit, comprises carrier gas grouting socket, carrier gas injection unit and carrier gas decanting point; Carrier gas access unit is used for carrier gas (as Ar) input, and the large young pathbreaker of carrier gas flux affects the gaseous reactant of generation (as SeH
2) sensitivity, carrier gas flux is excessive, and can dilute gaseous reactant thus desensitization, carrier gas flux is too small, can cause formed gaseous reactant cannot enter rapidly subsequent cell (as atomizer); Wherein carrier gas grouting socket, injects for carrier gas; Carrier gas injection unit, passes through for carrier gas, and barrier liquid oppositely enters; The micro-raceway groove of craspedodrome of carrier gas decanting point and the micro-reaction member of annular is tangent, effectively ensures the effect of carrier gas carrier band;
The micro-reaction member of described annular, for realizing the abundant reaction of reducing agent, reagent, sample, is convenient to the sample gas of the effective carrier band of carrier gas after gasification simultaneously;
Described gas-liquid separation unit, also comprises liquid outlet; Gas-liquid separation unit for effective separation of gaseous products, liquid product after realization response, that is: utilizes siphonic effect, be inhaled into the micro-raceway groove of capillary, and the carrier gas of carrier band gaseous products is still from micro-reactive channel track overflow through reacted liquid; Wherein liquid outlet, exports for reacted liquid product;
Described gas-liquid interval form monitoring means, also comprises gas delivery port and gas-liquid interval form monitoring form; Gas-liquid interval form monitoring means is used for monitoring micro-reaction raceway groove gas-liquid interval form and differentiate gas-liquid separation effect before and after gas-liquid separation unit, whether also there is gas-liquid and coexist phenomenon after namely observing micro-reaction raceway groove gas-liquid interval form before gas-liquid separation unit, observation gas-liquid separation unit.Wherein gas delivery port, exports for reacted gaseous products; Gas-liquid interval form monitoring form, for observing gas-liquid interval form and gas-liquid separation effect in micro-raceway groove;
Further, the described assembly fixed support that comprises 3 LED, 2 gradient-index lens, 1 tablet filter, transparent slide, PDMS, 1 high definition OEM camera model and processed by PMMA;
Described LED, for illumination, being convenient to high definition OEM camera model can state between gas-liquid in micro-raceway groove in the form monitoring means of clear collection gas-liquid interval;
Described gradient-index lens, assembles with being coupled of high definition OEM camera model for chip-scale gas-liquid separator, adjusts and aim at;
Described optical filter, for filtering interfering optical signal, the light in a certain wavelength range of elimination, plays the effect of monochromator, in order to strengthen image effect;
Described transparent slide, PDMS, for the preparation of chip-scale gas-liquid separator;
Described high definition OEM camera model, for gathering gas-liquid form in the micro-reaction raceway groove of gas-liquid interval form monitoring means;
The fixed support that described PMMA processes, for fixed L ED, chip-scale gas-liquid separator, gradient-index lens and optical filter etc.
Further, described control interface comprises LED drive circuit, micro pump and micro-valve Drive and Control Circuit, micro-suction pump control circuit and high definition OEM camera model control circuit;
Described LED drive circuit, for realizing LED drived control;
Described micro pump and micro-valve Drive and Control Circuit, for the accurate control of reducing agent, reagent, sample and carrier gas injection rate, and the output of carrier gas (containing through reacted gaseous reactant) controls;
Described micro-suction pump control circuit, the output for reacted liquid reactant controls;
Described high definition OEM camera model control circuit, initializes for high definition OEM camera model, the transmission of high speed image signals collecting and various control signal.
Further, the described chip-scale gas-liquid separator control system based on FPGA+DSP comprises FPGA system, dsp system and dual port RAM;
Described FPGA system, for realizing the control of chip gas-liquid separator and assembly thereof, high definition OEM camera model, realizes high speed image signals collecting;
Whether described dsp system, being effectively separated differentiation for realizing bubble positioning analysis, gas-liquid interval Morphological Identification and gas-liquid, processing view data;
Described dual port RAM, for realizing high speed data transfer between FPGA system, dsp system, reaches Data Matching effect.
Further, the described chip-scale gas-liquid separator control system based on FPGA+DSP comprises FPGA system, dsp system and dual port RAM;
Described FPGA system, for realizing the control of chip gas-liquid separator and assembly thereof, high definition OEM camera model, realizes high speed image signals collecting;
Whether described dsp system, be effectively separated differentiation etc. for realizing bubble positioning analysis, gas-liquid interval Morphological Identification and gas-liquid;
Described dual port RAM, for realizing high speed data transfer between FPGA system, dsp system, reaches Data Matching effect.
Further, described FPGA system comprises IIC IP Core configuration module, LED driving governor, micro pump and micro-valve control, micro-suction pump controller, NIOS II soft-core processor, high speed image pretreatment module, camera model controller, LCD display controller, sdram controller, Flash controller, dual port RAM controller;
Described IIC IP Core configuration module, initializes control for realizing high definition OEM camera model;
Described LED driving governor, controls for the control of LED powering order, luminous intensity;
Described micro pump and micro-valve control, for the orderly control of the accurate control of injection rate and gas, liquid pipeline;
Described micro-suction pump controller, for realizing the orderly control of micro-suction pump;
Described NIOSII soft-core processor, for realizing the Based Intelligent Control of each module of FPGA system;
Described high speed image pretreatment module, extracts process for realizing data filtering, noise reduction and view data;
Described camera model controller, controls and high speed image data acquisition for high definition OEM camera model;
Described sdram controller, for controlling high speed image data storage, data buffer storage etc.;
Described Flash controller, for the storage of data in control system and application program;
Described LCD display controller, for realizing the control of liquid crystal LCD display driver in integrated system;
Described dual port RAM controller, for the control of dual port RAM.
Further, described chip-scale gas-liquid separator control system also comprises electronic vapour-liquid valve group and motor driving controling circuit;
Electronic vapour-liquid valve group and motor driving controling circuit comprise electronic vapour-liquid valve group drive circuit, Micropump stepper motor driving circuit and the miniature electric aspiration pump motor-drive circuit that ULN2003A is formed;
The electric-air valve group drive circuit that described ULN2003A is formed, the electric-air valve/liquid valve in the corresponding entry/exit feed channel of opening/closing, realizes the orderly control of electronic gas, liquid valve;
Described Micropump stepper motor driving circuit and miniature electric aspiration pump motor-drive circuit, precisely control for reducing agent, reaction reagent, sample solution flow and the control of miniature electric aspiration pump.
Further, described IIC IP Core configuration module, LED driving governor, micro pump and micro-valve control, NIOS II soft-core processor, high speed image pretreatment module, camera model controller, LCD display controller, sdram controller, Flash controller, dual port RAM controller are encapsulated in single fpga chip by SOPC technology.
Beneficial effect of the present invention is: chip-scale gas-liquid separator provided by the invention and control system thereof, for specific core chip level gas-liquid separator (be micro-fluidic chip---atomic fluorescent on-line combined with integrated and chip-scale gas-liquid separator device that is that design), utilize MEMS technology to prepare chip-scale gas-liquid separator, realize high definition OEM camera model based on SOPC technology and to control and high speed image data acquisition, employing DSP technology realize high rate burst communication, as bubble diagram judges as positioning analysis, gas-liquid separation effect.It comprises chip-scale gas-liquid separator and assembly, control interface and the chip-scale gas-liquid separator control system based on FPGA+DSP.This system architecture flexibly, upgrading is easy, control mode is convenient, it is low in energy consumption, highly sensitive to have; Adopt SOPC+DSP technology to realize system architecture and can solve the traditional design method systemic-function scaling difficulty of employing, the problems such as maintainability flexibility that is poor and design is lower, effectively can simplify the structure of system, shorten from concept to the distance realized.
Accompanying drawing explanation
In order to make the object, technical solutions and advantages of the present invention clearly, below in conjunction with accompanying drawing, the present invention is described in further detail, wherein:
Fig. 1 is the Control system architecture schematic diagram based on chip-scale gas-liquid separator;
Fig. 2 is the structural representation of chip-scale gas-liquid separator;
Fig. 3 is carrier gas access unit, gas-liquid separation unit, microring array unit, gas-liquid interval form monitoring means structural representation;
Fig. 4 is the structural representation of chip-scale gas-liquid separator assembly;
Fig. 5 is chip-scale gas-liquid separator and control system gas-liquid tube topology schematic diagram thereof;
Wherein, chip and gas-liquid separator and assembly 1 thereof, high definition OEM camera model 2, micro-suction pump control circuit 3, micro pump and micro-valve Drive and Control Circuit 4, LED drive circuit 5, IIC IP Core configuration module 6, LED driving governor 7, micro pump and micro-valve control 8, micro-suction pump controller 9, camera model controller 10, high speed image pretreatment module 11, NIOS II soft-core processor 12, LCD display controller 13, sdram controller 14, Flash controller 15, dual port RAM controller 16, FPGA 17, DSP 18, high definition OEM camera model control circuit 19, gradient-index lens 20, slide 21, optical filter 22, PDMS 23, PMMA 24, LED 25, LCD display 26, jtag interface × 2 27, EPCS4 28, Flash (512K × 16) 29, dual port RAM 30, SDRAM (2M × 32) 31, Flash (256K × 32) 57, SDRAM (4M × 16) 58,
The micro-liquid storage tank of reducing agent/reagent/specimen 32, microring array unit 33, annular micro-reaction member 34, gas-liquid interval form monitoring means 35, carrier gas injection unit 36, carrier gas decanting point 37, carrier gas grouting socket 38, liquid outlet 39; Gas-liquid separation unit 40, gas delivery port 41, carrier gas access unit 42, carrier gas 43, containing the liquid reactant 44 of gaseous mixture, through reacted liquid reactants 45, the gas-liquid mixture 46 with certain gas-liquid interval form, carrier gas and through reacted gaseous reactant 47, reducing agent/reagent/specimen reactant liquor 48, CMOS/CCD imageing sensor 49;
Micropump fixed support 50, miniature carrier gas steel cylinder 51, electric-air valve 52, pressure-reducing valve 53, atomizer 54, electronic liquid valve 55, miniature electric aspiration pump 56.
Detailed description of the invention
Below in conjunction with accompanying drawing, the preferred embodiments of the present invention are described in detail.
Fig. 1 is the Control system architecture schematic diagram based on chip-scale gas-liquid separator, Fig. 2, Fig. 3, Fig. 4 shows chip-scale gas-liquid separator and modular construction schematic diagram thereof, as shown in Figure 2, chip-scale gas-liquid separator adopts MEMS technology to be prepared from by PDMS 24 and transparent slide 22, fixed at the PMMA of employing up and down 24 of chip and gas-liquid separator, respectively on chip gas-liquid separator, left, right placement 3 LED 25, throw light on when monitoring gas-liquid interval form for CMOS/CCD imageing sensor 49, 2 gradient-index lens 20 and optical filter 23 is placed immediately below the gas-liquid interval form monitoring means 35 of chip-scale gas-liquid separator, make CMOS/CCD imageing sensor 49 clearly can gather the gas-liquid form of two observation raceway grooves in gas-liquid interval form monitoring means 35, CMOS/CCD imageing sensor 49 is integrated in high definition OEM camera module, carrier gas 43 is through exporting at its grouting socket 38, annular micro-reaction member 34 is injected at carrier gas decanting point 37 through carrier gas winding type injection unit 36, during design, tangent at the micro-raceway groove of craspedodrome of the micro-raceway groove in carrier gas decanting point 37 carrier gas side and the micro-reaction member of annular 34, and carrier gas micrometer raceway groove is thinner than the micro-raceway groove of annular micro-reaction member 34.
Fig. 5 shows chip-scale gas-liquid separator and control system gas-liquid tube topology schematic diagram thereof, as shown in the figure, chip-scale gas-liquid separator provided by the invention and control system thereof, comprise chip-scale gas-liquid separator and assembly, control interface and the chip-scale gas-liquid separator control system based on FPGA+DSP.
Chip-scale gas-liquid separator and assembly thereof are for realizing the liquid-liquid fluid system microring array under micro-volume condition, micro-reaction, gas-liquid separation, gas-liquid interval form (as bubble flow, interval stream, circulation) and gas-liquid separation effect in the micro-reaction raceway groove of Real-Time Monitoring annular, so that control system dynamic conditioning flow rate of carrier gas and reaction mixture flow velocity, to realize best gas-liquid separation effect.
Chip-scale gas-liquid separator adopts MEMS technology to be prepared from by PDMS and transparent slide, is integrated with the micro-liquid storage tank of reducing agent/reagent/specimen, microring array unit, annular micro-reaction member, gas-liquid interval form monitoring means, carrier gas injection unit, carrier gas decanting point, carrier gas grouting socket, liquid outlet; The unit such as gas-liquid separation unit, gas delivery port, by PMMA fixed L ED, chip-scale gas-liquid separator, gradient-index lens, optical filter, and is assembled into chip gas-liquid separator and assembly thereof together with high definition OEM camera model.
Before work, under the control of NIOS II soft-core processor, control Micropump, micro-air valve, micro-liquid valve and miniature electric aspiration pump, ensure that in chip and gas-liquid separator, micro-raceway groove is unimpeded, during work, Micropump is injected respectively from reducing agent from reducing agent/reagent/specimen liquid storage tank 32 by Micropump, reaction reagent, sample solution, after microring array unit fully mixes, send into annular micro-reaction member, carrier gas is injected at carrier gas decanting point, fully mix through multi-turn, after reaction, send into gas-liquid separation unit, for ensureing gas-liquid separation effect, miniature electric aspiration pump is connect at liquid outlet, negative pressure mode is adopted to ensure separating effect, gas after gas-liquid separator (is mixed with carrier gas, through reacted gaseous reactant) export from gas delivery port, send into atomizer again and carry out atomic spectra analysis.
Described interface circuit is connected between chip-scale gas-liquid separator control system and chip-scale gas-liquid separator and assembly thereof, for the driving to micro pump and micro-valve, to realize mixed reaction solution flow control; For the driving to micro-air valve, to realize the control of flow rate of carrier gas; For the driving to micro-suction pump, to realize solution-airmixture Ngatively pressurized sampling; For the control to high definition OEM camera module, to realize initialization, the high-speed image sampling of high definition OEM camera module.
Described chip-scale gas-liquid separator control system, adopt FPGA+DSP framework mode, gas-liquid interval form in required various control signals, the micro-reaction raceway groove of Real-Time Monitoring (as bubble flow, interval stream, circulation) is effectively separated for generation of chip-scale gas-liquid separator, dynamic conditioning flow rate of carrier gas and reaction mixture flow velocity, to realize best gas-liquid separation effect.
As shown in Figure 2 and Figure 3, the chip-scale gas-liquid separator in chip-scale gas-liquid separator and assembly 1 thereof comprises microring array unit 33, carrier gas access unit 42, annular micro-reaction member 34, gas-liquid separation unit 40 and gas-liquid interval form monitoring means 35.Wherein, carrier gas 43, containing the liquid reactant 44 of gaseous mixture, through reacted liquid reactants 45, the gas-liquid mixture 46 with certain gas-liquid interval form, carrier gas and through reacted gaseous reactant 47.
Microring array unit 33, also comprises the micro-liquid storage tank 32 of reducing agent/reagent/specimen; Microring array unit for realizing effective mixing of reducing agent, reagent, sample, or contains gaseous mixture enrichment, to improve gaseous reactant to be measured (as SeH for multichannel through reacted
2) content; The wherein micro-liquid storage tank of reducing agent/reagent/specimen, for realizing reducing agent, reaction reagent, sample solution injection, storage.
Carrier gas access unit 42, comprises carrier gas grouting socket 38, carrier gas injection unit 36 and carrier gas decanting point 37; Carrier gas access unit is used for carrier gas (as Ar) input, and the large young pathbreaker of carrier gas flux affects the gaseous reactant of generation (as SeH
2) sensitivity, carrier gas flux is excessive, and can dilute gaseous reactant thus desensitization, carrier gas flux is too small, can cause formed gaseous reactant cannot enter rapidly subsequent cell (as atomizer); Wherein carrier gas grouting socket, injects for carrier gas; Carrier gas injection unit, passes through for carrier gas, and barrier liquid oppositely enters; The micro-raceway groove of craspedodrome of carrier gas decanting point and the micro-reaction member of annular is tangent, effectively ensures the effect of carrier gas carrier band.
The micro-reaction member 34 of annular, for realizing the abundant reaction of reducing agent, reagent, sample, is convenient to the sample gas of the effective carrier band of carrier gas after gasification simultaneously.
Gas-liquid separation unit 40, also comprises liquid outlet 41; Gas-liquid separation unit for effective separation of gaseous products, liquid product after realization response, that is: utilizes siphonic effect, be inhaled into the micro-raceway groove of capillary, and the carrier gas of carrier band gaseous products is still from micro-reactive channel track overflow through reacted liquid; Wherein liquid outlet, exports for reacted liquid product.
Gas-liquid interval form monitoring means 35, also comprises gas delivery port 41 and gas-liquid interval form monitoring form 48; Gas-liquid interval form monitoring means is used for monitoring micro-reaction raceway groove gas-liquid interval form and differentiate gas-liquid separation effect before and after gas-liquid separation unit, whether also there is gas-liquid and coexist phenomenon after namely observing micro-reaction raceway groove gas-liquid interval form before gas-liquid separation unit, observation gas-liquid separation unit; Wherein gas delivery port, exports for reacted gaseous products; Gas-liquid interval form monitoring form, for observing gas-liquid interval form and gas-liquid separation effect in micro-raceway groove.
As shown in Figure 4, the assembly in chip-scale gas-liquid separator and assembly 1 thereof comprises gradient-index lens 20, transparent slide 21, optical filter 22, PDMS 23, PMMA 24, LED 25 and high definition OEM camera module 2 (being integrated with CMOS/CCD imageing sensor 49);
Described gradient-index lens, assembles with being coupled of high definition OEM camera model for chip-scale gas-liquid separator, adjusts and aim at.
Described transparent slide, PDMS, for the preparation of chip-scale gas-liquid separator;
Described optical filter, for the light in elimination one wavelength range, plays the effect of monochromator, in order to strengthen image effect, and filtering interfering optical signal.
Described PMMA, for making support, for fixed L ED, chip-scale gas-liquid separator, gradient-index lens and optical filter.
Described high definition OEM camera module, for gathering gas-liquid form in the micro-reaction raceway groove of gas-liquid interval form monitoring means.
Chip-scale gas-liquid separator control interface comprises LED drive circuit 5, micro pump and micro-valve Drive and Control Circuit 4, micro-suction pump control circuit 3, high definition OEM camera model control circuit 19.
Described LED drive circuit, for realizing LED drived control, for the gas-liquid interval form monitoring form that throws light on, being convenient to high definition OEM camera model and collecting image clearly.
Described micro pump and micro-valve Drive and Control Circuit, for the accurate control of reducing agent, reagent, sample and carrier gas injection rate, and the output of carrier gas (containing through reacted gaseous reactant) controls, and realizes gas, the ON/OFF of liquid pipeline controls in order.
Described micro-suction pump control circuit, the output for reacted liquid reactant controls.
Described high definition OEM camera model control circuit, initializes for high definition OEM camera model, the transmission of high speed image signals collecting and various control signal.
Chip-scale gas-liquid separator control system based on FPGA+DSP comprises FPGA system 17, dsp system 18 and dual port RAM 30.
Described FPGA system, for realizing the control of chip gas-liquid separator and assembly thereof, high definition OEM camera model, realizes high speed image signals collecting.
Described dsp system, for view data high speed processing, realizes bubble positioning analysis, gas-liquid interval Morphological Identification and gas-liquid and whether is effectively separated differentiation.
Described dual port RAM, for realizing high speed data transfer between FPGA system, dsp system, reaches Data Matching effect.
FPGA system comprises IIC IP Core configuration module 6, LED driving governor 7, micro pump and micro-valve control 8, micro-suction pump controller 9, camera model controller 10, high speed image pretreatment module 11, NIOS II soft-core processor 12, LCD display controller 13, sdram controller 14, Flash controller 15, dual port RAM controller 16, LCD display 26, jtag interface × 2 27, EPCS4 28, Flash (512K × 16) 29, SDRAM (2M × 32) 31, Flash (256K × 32) 57, SDRAM (4M × 16) 58.
Described IIC IP Core configuration module, for high definition OEM camera model initial configuration.
Described LED driving governor, for starting/closing LED and the control bright to illumination light.
Described micro pump and micro-valve control, for realizing the orderly control of Micropump, electric-air valve, liquid valve.
Described micro-suction pump controller, for realizing the orderly control of micro-suction pump.
Described camera model controller, controls and high speed image data acquisition for high definition OEM camera model.
Described high speed image pretreatment module, for realizing the process such as data filtering, noise reduction and view data extraction.
Described NIOSII soft-core processor, for realizing the Based Intelligent Control of each module of FPGA system.
Described lcd controller, for realizing the control of liquid crystal LCD display driver in integrated system.
Described sdram controller, for controlling, high speed image data stores, data buffer storage, the control of data buffer memory in FPGA system---synchronous DRAM (SDRAM).
Described Flash controller, for the memory of data, application storage in FPGA system---the control of flash storage.
Described dual port RAM controller, realizes high speed data transfer between FPGA system, dsp system, reaches Data Matching effect.
Described IIC IP Core configuration module 6, LED driving governor 7, micro pump and micro-valve control 8, micro-suction pump controller 9, camera model controller 10, high speed image pretreatment module 11, NIOS II soft-core processor 12, LCD display controller 13, sdram controller 14, Flash controller 15, dual port RAM controller are encapsulated in single fpga chip by SOPC technology.
Chip-scale gas-liquid separator control system also comprises electronic vapour-liquid valve group and motor driving controling circuit; Electronic vapour-liquid valve group and motor driving controling circuit comprise electronic vapour-liquid valve group drive circuit, Micropump stepper motor driving circuit and the miniature electric aspiration pump motor-drive circuit that ULN2003A is formed.
The electric-air valve group drive circuit that ULN2003A is formed, the electric-air valve/liquid valve in the corresponding entry/exit feed channel of opening/closing, realizes the orderly control of electronic gas, liquid valve.
Micropump stepper motor driving circuit and miniature electric aspiration pump motor-drive circuit, precisely control for reducing agent, reaction reagent, sample solution flow and the control of miniature electric aspiration pump.
What finally illustrate is, above preferred embodiment is only in order to illustrate technical scheme of the present invention and unrestricted, although by above preferred embodiment to invention has been detailed description, but those skilled in the art are to be understood that, various change can be made to it in the form and details, and not depart from claims of the present invention limited range.
Claims (8)
1. chip-scale gas-liquid separator and control system thereof, is characterized in that: comprise chip-scale gas-liquid separator and assembly, control interface and the chip-scale gas-liquid separator control system based on FPGA+DSP;
Described chip-scale gas-liquid separator and assembly thereof are for realizing the liquid-liquid fluid system microring array under micro-volume condition, micro-reaction, gas-liquid separation, gas-liquid interval form and gas-liquid separation effect in the micro-reaction raceway groove of Real-Time Monitoring annular, make control system can dynamic conditioning flow rate of carrier gas and reaction mixture flow velocity;
Described interface circuit is connected between chip-scale gas-liquid separator control system and chip-scale gas-liquid separator and assembly thereof, for the driving to micro pump and micro-valve, realizes mixed reaction solution flow control; For the driving to micro-air valve, liquid valve, realize that Air-liquid pipeline controls in order, the control of flow rate of carrier gas; For the driving to micro-suction pump, realize gas-liquid separation, ensure reactant mixture Ngatively pressurized sampling; For the control to high definition OEM camera module, realize the initialization of high definition OEM camera module, high-speed image sampling;
Described chip-scale gas-liquid separator control system, adopt FPGA+DSP framework mode, gas-liquid interval form, dynamic conditioning flow rate of carrier gas and reaction mixture flow velocity in required control signal, the micro-reaction raceway groove of Real-Time Monitoring is effectively separated for generation of chip-scale gas-liquid separator.
2. chip-scale gas-liquid separator according to claim 1 and control system thereof, it is characterized in that: described chip-scale gas-liquid separator is prepared from by dimethyl silicone polymer and transparent slide, comprise microring array unit, carrier gas access unit, annular micro-reaction member, gas-liquid separation unit and gas-liquid interval form monitoring means;
Described microring array unit, also comprises the micro-liquid storage tank of reducing agent/reagent/specimen; Microring array unit is for realizing the mixing of reducing agent, reagent, sample, and multichannel containing gaseous mixture enrichment, improves gaseous reactant content to be measured through reacted; The wherein micro-liquid storage tank of reducing agent/reagent/specimen, for realizing reducing agent, reaction reagent, sample solution injection, storage;
Described carrier gas access unit, comprises carrier gas grouting socket, carrier gas injection unit and carrier gas decanting point; Carrier gas access unit is used for carrier gas input; Wherein carrier gas grouting socket, injects for carrier gas; Carrier gas injection unit, passes through for carrier gas, and barrier liquid oppositely enters; The micro-raceway groove of craspedodrome of carrier gas decanting point and the micro-reaction member of annular is tangent, ensures the effect of carrier gas carrier band;
The micro-reaction member of described annular, for realizing the abundant reaction of reducing agent, reagent, sample, is convenient to the sample gas of carrier gas carrier band after gasification simultaneously;
Described gas-liquid separation unit, also comprises liquid outlet; Gas-liquid separation unit is for the separation of gaseous products, liquid product after realization response; Wherein liquid outlet, exports for reacted liquid product;
Described gas-liquid interval form monitoring means, also comprises gas delivery port and gas-liquid interval form monitoring form; Gas-liquid interval form monitoring means is used for monitoring micro-reaction raceway groove gas-liquid interval form and differentiation gas-liquid separation effect before and after gas-liquid separation unit; Wherein gas delivery port, exports for reacted gaseous products; Gas-liquid interval form monitoring form, for observing gas-liquid interval form and gas-liquid separation effect in micro-raceway groove.
3. chip-scale gas-liquid separator according to claim 1 and control system thereof, is characterized in that: the fixed support that described assembly comprises 3 LED, 2 gradient-index lens, 1 tablet filter, transparent slide, PDMS, 1 high definition OEM camera model and processed by PMMA;
Described LED, for illumination, being convenient to high definition OEM camera model can state between gas-liquid in micro-raceway groove in the form monitoring means of clear collection gas-liquid interval;
Described gradient-index lens, assembles with being coupled of high definition OEM camera model for chip-scale gas-liquid separator, adjusts and aim at;
Described optical filter, for filtering interfering optical signal;
Described transparent slide, PDMS, for the preparation of chip-scale gas-liquid separator;
Described high definition OEM camera model, for gathering gas-liquid form in the micro-reaction raceway groove of gas-liquid interval form monitoring means;
The fixed support that described PMMA processes, for fixed L ED, chip-scale gas-liquid separator, gradient-index lens and optical filter.
4. chip-scale gas-liquid separator according to claim 1 and control system thereof, is characterized in that: described control interface comprises LED drive circuit, micro pump and micro-valve Drive and Control Circuit, micro-suction pump control circuit and high definition OEM camera model control circuit;
Described LED drive circuit, for realizing LED drived control;
Described micro pump and micro-valve Drive and Control Circuit, for the accurate control of reducing agent, reagent, sample and carrier gas injection rate, and the output of carrier gas controls;
Described micro-suction pump control circuit, the output for reacted liquid reactant controls;
Described high definition OEM camera model control circuit, initializes for high definition OEM camera model, the transmission of high speed image signals collecting and various control signal.
5. chip-scale gas-liquid separator according to claim 1 and control system thereof, is characterized in that: the described chip-scale gas-liquid separator control system based on FPGA+DSP comprises FPGA system, dsp system and dual port RAM;
Described FPGA system, for realizing the control of chip gas-liquid separator and assembly thereof, high definition OEM camera model, realizes high speed image signals collecting;
Whether described dsp system, being effectively separated differentiation for realizing bubble positioning analysis, gas-liquid interval Morphological Identification and gas-liquid, processing view data;
Described dual port RAM, for realizing high speed data transfer between FPGA system, dsp system, reaches Data Matching effect.
6. chip-scale gas-liquid separator according to claim 5 and control system thereof, is characterized in that: described FPGA system comprises IIC IP Core configuration module, LED driving governor, micro pump and micro-valve control, micro-suction pump controller, NIOS II soft-core processor, high speed image pretreatment module, camera model controller, LCD display controller, sdram controller, Flash controller, dual port RAM controller;
Described IIC IP Core configuration module, initializes control for realizing high definition OEM camera model;
Described LED driving governor, controls for the control of LED powering order, luminous intensity;
Described micro pump and micro-valve control, for realizing the orderly control of Micropump, electric-air valve, liquid valve;
Described micro-suction pump controller, for realizing the orderly control of micro-suction pump;
Described NIOSII soft-core processor, for realizing the Based Intelligent Control of each module of FPGA system;
Described high speed image pretreatment module, extracts process for realizing data filtering, noise reduction and view data;
Described camera model controller, controls and high speed image data acquisition for high definition OEM camera model;
Described sdram controller, for controlling, high speed image data stores, data buffer storage;
Described Flash controller, for the storage of data in control system and application program;
Described LCD display controller, for realizing the control of liquid crystal LCD display driver in integrated system;
Described dual port RAM controller, for the control of dual port RAM.
7. chip-scale gas-liquid separator according to claim 5 and control system thereof, is characterized in that: described chip-scale gas-liquid separator control system also comprises electronic vapour-liquid valve group and motor driving controling circuit;
Electronic vapour-liquid valve group and motor driving controling circuit comprise electronic vapour-liquid valve group drive circuit, Micropump stepper motor driving circuit and the miniature electric aspiration pump motor-drive circuit that ULN2003A is formed;
The electric-air valve group drive circuit that described ULN2003A is formed, the electric-air valve/liquid valve in the corresponding entry/exit feed channel of opening/closing, realizes the orderly control of electronic gas, liquid valve;
Described Micropump stepper motor driving circuit and miniature electric aspiration pump motor-drive circuit, precisely control for reducing agent, reaction reagent, sample solution flow and the control of miniature electric aspiration pump.
8. chip-scale gas-liquid separator according to claim 6 and control system thereof, is characterized in that: described IIC IP Core configuration module, LED driving governor, micro pump and micro-valve control, micro-suction pump controller, NIOS II soft-core processor, high speed image pretreatment module, camera model controller, LCD display controller, sdram controller, Flash controller, dual port RAM controller are encapsulated in single fpga chip by SOPC technology.
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