CN104306816A - Chinese patent medicine for treating gout - Google Patents
Chinese patent medicine for treating gout Download PDFInfo
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- CN104306816A CN104306816A CN201410578155.3A CN201410578155A CN104306816A CN 104306816 A CN104306816 A CN 104306816A CN 201410578155 A CN201410578155 A CN 201410578155A CN 104306816 A CN104306816 A CN 104306816A
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- treating gout
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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Abstract
The invention provides a Chinese patent medicine for treating gout. The compound preparation capable of reducing concentration of serum uric acid and treating gout is characterized by being prepared from the following components in percentage by weight: 30 percent of rhizoma smilacis glabrae, 15 percent of yam rhizome, 10 percent of benzbromarone, 10 percent of eleutheroside, 5 percent of picroside, 10 percent of triptolide, 10 percent of croceic acid and 10 percent of cordycepic acid, and the eight medicinal materials are mixed according to the proportion to prepare a tablet. The tablet or pill is orally taken for 0.5-1.0g each time, and is taken three times a day with warm boiled water after meals, and is taken continuously for 2-3 weeks.
Description
Technical field
The present invention relates to a kind of compound oral tablet, referring to that one can reduce uric acid concentration in blood more specifically, the compound preparation for the treatment of gout.
Background technology
Gout is common chronic disease.The medicine for the treatment of gout commercially available at present is all difficult to radical cure gout disease, cure the symptoms, not the disease, and toxic and side effects is comparatively large, once gout easily aggravates outbreak repeatedly after drug withdrawal.
Summary of the invention
Technical problem to be solved by this invention, is overcome deficiency of the prior art, provides a kind of safety, effectively, and the oral drugs that toxic and side effects is little.
The present invention adopts with Rhizoma Smilacis Glabrae (its English Glabrous Greenbrier Rhizome by name, Rhizome of Glabrous Greenbrier) based on, be equipped with Rhizoma Dioscoreae Septemlobae (its English Castor seed by name), benzbromarone (its English Benzbromarone by name, molecular formula is C17H12Br2O3, molecular weight is 424.08), Radix Et Caulis Acanthopanacis Senticosi glucoside (its English Syringin by name, molecular formula is C17H24O9, molecular weight is 372.37), picroside (its English literary fame claims Picroside molecular formula C25H30O13 molecular weight 538.499), triptolide (its English Triptolide by name, molecular formula is C20H24O6, molecular weight is 360.4), crocetin (its English croceic acid by name), cordycepic acid (its English Cordycepic acid by name, molecular formula is C6H14O6), make oral tablet or pill, treatment gout, special effect is had to uric acid concentration in the blood of stable human normal.Main component of the present invention and proportioning thereof are: Rhizoma Smilacis Glabrae 30% ， Rhizoma Dioscoreae Septemlobae 15%, benzbromarone 10%, Radix Et Caulis Acanthopanacis Senticosi glucoside 10%, picroside 5%, triptolide 10%, crocetin 10%, cordycepic acid 10%.
Rhizoma Smilacis Glabrae is the dry rhizome of liliaceous plant smilacis glabra SmilaxglabraRoxb..Dehumidifying, removing toxic substances, easing joint movement." detailed outline ": Rhizoma Smilacis Glabrae energy strengthening the spleen and stomach, curing rheumatism, the strong then battalion of taste defend from, rheumatism goes then muscles and bones profit." book on Chinese herbal medicine is new again ": damp eliminating heat, relieving rigidity of muscles and joints.The Astilbin (Astilbin) that extraction and isolation obtains from Rhizoma Smilacis Glabrae has obvious analgesic activity.Tail vein injection 1mgkg ~ 4mgkg Astilbin obviously can suppress white mice glacial acetic acid writhing response number of times; Injection 2.5mgkg ~ 10mgkg Astilbin can extend the latency of pain response that mouse hot-plate causes, and shows that Astilbin has obvious analgesic activity.) Astilbin obviously can increase the total amount of urinating of rat, and have dose-response relationship, after administration, lh can increase urine Na+ output, but discharges urine K+ and obviously do not change.We utilize the analgesic activity of Rhizoma Smilacis Glabrae, and diuresis is that principal agent have developed this safety, effectively, and the compound oral tablet safety that toxic and side effects is little, effectively, treatment gout.
Rhizoma Dioscoreae Septemlobae is Dioscoreaceae is herbaceous plant Rhizoma Dioscoreae Septemlobae dry rhizome for many years.Dispel the wind, dampness removing.Dispelling the wind and dampness pathogens insensitive impediment, lumbocrural pain, dysuria." herbal classic ": main lumbago and backache, bone strengthening saves, wind and cold wetted perimeter numbness." the southern regions of the Yunnan Province book on Chinese herbal medicine ": control wind and cold, warming the meridian network, waist knee joint aches, stupid fiber crops all over, sharp bladder water channel, red white turbid urine.
。" detailed outline ": " Rhizoma Dioscoreae Septemlobae, bright, the JUE YIN meridian medicine of foot sun also.Cloudy main muscle of fainting belongs to wind, and the bright main meat of sun belongs to the merit of wet ， Rhizoma Dioscoreae Septemlobae, is longer than curing rheumatism, so can control slow weak insensitive impediment, lose genus rheumatism person that is turbid, all diseases of malignant boil.Rhizoma Smilacis Glabrae compatibility Rhizoma Dioscoreae Septemlobae, two medicines all have the merit of promoting diuresis with drugs of tasteless flavour, sharp joint, wind-damp dispelling.But Rhizoma Smilacis Glabrae relatively removing toxic substances ， Rhizoma Dioscoreae Septemlobae is longer than diuresis.The two compatibility, has effect of removing toxic substances dehumidifying, easing joint movement.
Benzbromarone is benzofuran derivative, has suppression
renal tubulesthus uric acid concentration in blood is reduced to the resorption of uric acid.
For medical research, Radix Et Caulis Acanthopanacis Senticosi glucoside proves that the action character of Radix Et Caulis Acanthopanacis Senticosi is substantially identical with Radix Ginseng, have and regulate body disorderly, the function such as invigorating middle warmer, benefit essence, strong will, wind-damp dispelling, strengthening bone and muscle, blood circulation and promoting silt, stomach invigorating diuresis.Clothes of a specified duration are made light of one's life by commiting suicide and are endured hardships.It can stimulate mind & body vigor.Numerous scientific publications about Radix Et Caulis Acanthopanacis Senticosi demonstrates its antifatigue effect, strengthens the ability of endurance, increases alert and resourceful and learning capacity.Numerous usage obtains confirmation all in human experimentation.Radix Et Caulis Acanthopanacis Senticosi glucoside has the effect obviously reducing uric acid concentration in blood.
Picroside is Rhizoma Picrorhizae extract.Rhizoma Picrorhizae is the dry rhizome of goatweed Rhizoma Picrorhizae Picrorhiza scrophulariiflora Pennell.Return liver, stomach, large intestine channel.Heat clearing away, removing heat from blood, dampness.Containing 3 kinds of iridoid glycosides and Kutkosid I, II, III(picroside I, II, III), kutkinol, kutkisterol, vanillic acid, cinnamic acid, ferulic acid, acetovanilone, PEARLITOL 25C etc., in addition containing the volatile oil of resin, tannic acid, tripalmitin and type sesquiterpene." book on Chinese herbal medicine justice ": by the use of Rhizoma Picrorhizae, know the same merit with Rhizoma Coptidis.Only the property of sedimentation is especially fast, therefore leads damp-heat in lower-JIAO clearly, and its power is more special, and it imitates comparatively Rhizoma Coptidis is victory.
Triptolide has resisting rheumatoid disease, antitumaous effect.
Crocetin has resisting rheumatoid disease, reduces the effect of uric acid concentration in blood.
Cordycepic acid has anti-liver tissue fibrosis, the effect of anti peroxidation of lipid.
Detailed description of the invention:
The present invention uses 200 cases, each oral tablet or pill 0.5-1.0g, every day three times, swallows after meal by warm water, serve on 2-3 week, have good curative effect to gout disease, and after one week, in blood, uric acid concentration all controlled in normal range, and toxic and side effects appears in none example.So far half a year at least after taking medicine, there is not uric acid concentration rebound phenomena in blood at most more than a year.
Claims (1)
1. one kind is reduced the compound preparation of uric acid concentration in blood, it is characterized in that its one-tenth be grouped into and proportioning as follows: Rhizoma Smilacis Glabrae 30%; Rhizoma Dioscoreae Septemlobae 15%, benzbromarone 10%, Radix Et Caulis Acanthopanacis Senticosi glucoside 10%, picroside 5%, triptolide 10%, crocetin 10%, cordycepic acid 10%, above-mentioned eight herbal medicines by proportioning porphyrize, uniform stirring makes tablet or pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410578155.3A CN104306816A (en) | 2014-10-27 | 2014-10-27 | Chinese patent medicine for treating gout |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410578155.3A CN104306816A (en) | 2014-10-27 | 2014-10-27 | Chinese patent medicine for treating gout |
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| Publication Number | Publication Date |
|---|---|
| CN104306816A true CN104306816A (en) | 2015-01-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410578155.3A Pending CN104306816A (en) | 2014-10-27 | 2014-10-27 | Chinese patent medicine for treating gout |
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| Country | Link |
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| CN (1) | CN104306816A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106692158A (en) * | 2017-01-18 | 2017-05-24 | 广东省微生物研究所 | Application of vitamin B1, cordycepic acid and riboflavin and composition thereof in uric acid-lowering drugs |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103070878A (en) * | 2012-12-11 | 2013-05-01 | 上海浦东高星生物技术研究所 | Compound Caulis Sinomenii tablet |
-
2014
- 2014-10-27 CN CN201410578155.3A patent/CN104306816A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103070878A (en) * | 2012-12-11 | 2013-05-01 | 上海浦东高星生物技术研究所 | Compound Caulis Sinomenii tablet |
Non-Patent Citations (2)
| Title |
|---|
| 刘文军等: "《肾病名家灵验药对》", 31 January 2010 * |
| 单书健等: "《古今名医临证金鉴 痹证 下》", 31 July 2011 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106692158A (en) * | 2017-01-18 | 2017-05-24 | 广东省微生物研究所 | Application of vitamin B1, cordycepic acid and riboflavin and composition thereof in uric acid-lowering drugs |
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150128 |
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| RJ01 | Rejection of invention patent application after publication |