CN104306544A - 一种用于治疗慢性萎缩性胃炎的中药组合物及其制备方法和应用 - Google Patents
一种用于治疗慢性萎缩性胃炎的中药组合物及其制备方法和应用 Download PDFInfo
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Abstract
本发明提供了一种用于治疗慢性萎缩性胃炎的中药组合物,由秋木瓜、草石蚕、三股筋、水栀根等组成,通过水提醇沉、喷雾干燥得方法制备,能治疗慢性萎缩性胃炎的目的。
Description
技术领域
本发明涉及中药技术领域,具体涉及一种用于治疗慢性萎缩性胃炎的中药组合物及其制备方法和应用。
背景技术
慢性萎缩性胃炎为常见胃部疾病,其发病率随年龄的增大而明显增多。主要表现为上腹部饱胀、不适或疼痛,餐后明显,同时伴有其他消化不良症状如嗳气、反酸、恶心、呕吐、食欲不振等。目前尚缺乏有效安全的药品。
发明内容
发明目的:为了解决上述问题,本发明的目的在于提供一种用于治疗慢性萎缩性胃炎的中药组合物及其制备方法和应用。
技术方案:本发明的目的是通过如下的方案实现的:
一种用于治疗慢性萎缩性胃炎的中药组合物,它由如下重量份数的原料制备得到:秋木瓜12份、草石蚕8份、三股筋14份、水栀根12份、野藿香10份、假蒟果穗16份、猫儿屎8份、闹狗药12份、佛葵14份、定心散12份、山蒟8份、翼首草10份、风箱树根14份、千金藤12份、算盘子8份。
所述用于治疗慢性萎缩性胃炎的中药组合物,所述原料经提取后添加辅料制成片剂、胶囊或颗粒剂。
所述用于治疗慢性萎缩性胃炎的中药组合物,所述辅料为糊精、乳糖、淀粉、蔗糖、葡萄糖、微晶纤维素、甘露糖、甲基纤维素、羟丙基纤维素、羧甲基纤维素和甜菊苷的一种或几种。
所述用于治疗慢性萎缩性胃炎的中药组合物,制备方法包括如下步骤:取药材合并,加水煎煮两次,合并煎液,减压浓缩至65℃时相对密度为1.15-1.20的浸膏,加乙醇使含醇量的体积百分比达75-85%,搅拌,静置,过滤,滤液减压浓缩至65℃时相对密度为1.25-1.30,并回收乙醇,得浓缩液,将浓缩液喷雾干燥,添加辅料制成胶囊剂、片剂、颗粒剂。
所述用于治疗慢性萎缩性胃炎的中药组合物,制备方法步骤中煎煮条件为:第一次加水为药材重量的8-12倍量,煎煮1-2h,第二次加水为药材重量的6-10倍量,煎煮1-2h。
所述用于治疗慢性萎缩性胃炎的中药组合物,制备方法步骤中喷雾干燥条件为:进风温度为100-120℃,出风温度为80-90℃,物料温度为70-90℃,雾化压力为0.2-0.4兆帕,喷雾速度为5-10ml/s。
所述用于治疗慢性萎缩性胃炎的中药组合物在制备治疗慢性萎缩性胃炎的药物中的应用。
秋木瓜为蔷薇科植物秋木瓜的果实。舒肝和胃,除湿止痛。治吐泻胸闷不适,风湿筋骨疼痛,脚气。
草石蚕为唇形科水苏属植物甘露子Stachys sieboldi Miq.,以全草或块茎入药。夏季采全草,秋季采挖块茎,洗净,鲜用或晒干。祛风热利湿,活血散瘀。用于黄疸,尿路感染,风热感冒,肺结核;外用治疮毒肿痛,蛇虫咬伤。
三股筋为樟科植物少花新樟的叶。祛风湿,舒筋络,止血。治风湿痹症,跌打伤痛,刀伤出血。
水栀根为茜草科植物大花栀子的根。解热凉血,镇静止痛,疏风除湿。
野藿香为唇形科植物冠唇花的全草,夏、秋采收,晒干,具有芳香健胃、温中理气的功效。
假蒟果穗为胡椒科植物假蒟的果穗,温中暖胃,驱风行气。治腹胀腹痛,肠炎腹泻,食欲不振,肾炎水肿,风湿痛。
猫儿屎为木通科(Lardizabalaceae)植物矮杞树Decaisnea fargesii Franch.的干燥根或果实。根:清肺止咳,祛风除湿;果:清热解毒,润燥。根用于肺痨咳嗽,风湿关节痛。果用于皮肤皲裂及肛裂,阴痒。
闹狗药为夹竹桃科植物小鸡骨常山的叶。散血止痛,排脓生肌。治刀伤出血,疮毒。
佛葵为茄科植物单花红丝线的全草。主治杀虫,去毒。治锈耳疮,鼻疮,痈肿疮毒。
定心散为莲座蕨科植物定心散莲座蕨的带叶柄基部的根茎。主要用于治神经衰弱,精神分裂症,热病抽搐等。
山蒟,常绿攀缘藤本,胡椒科属胡椒属,祛风湿,强腰膝。治风湿痛,风寒骨痛,腰膝无力,肌肉萎缩,咳嗽气喘。
翼首草为川续断科翼首花属植物匙叶翼首花Pterocephalus hookeri(Clarke)Hoeck,以带根全草入药。清热解表,清心凉血。用于感冒发热及各种温热病引起的发烧,心中烦热,咳血,吐血,尿血,便血。
风箱树根为茜草科植物风箱树的根或根皮。清热化湿,散瘀消肿。治感冒发热,咳嗽,咽喉肿痛,肠炎,菌痢,痈肿,跌打瘀痛。
算盘子,拉丁名为Glochidion puberum L,大戟科算盘子种。清热解毒,消滞止泻。
千金藤为防己科植物千金藤的根或茎叶。清热解毒,利尿消肿,祛风活络。治疟疾,痢疾,风湿痹痛,水肿,淋浊,咽喉肿痛,痈肿,疮疖。
有益效果:本发明用于治疗慢性萎缩性胃炎。
具体实施方式
以下通过实施例形式,对本发明的上述内容再作进一步的详细说明,但不应将此理解为本发明上述主题的范围仅限于以下的实例,凡基于本发明上述内容所实现的技术均属于本发明的范围。
1、制备实施例
实施例1:取秋木瓜12g、草石蚕8g、三股筋14g、水栀根12g、野藿香10g、假蒟果穗16g、猫儿屎8g、闹狗药12g、佛葵14g、定心散12g、山蒟8g、翼首草10g、风箱树根14g、千金藤12g、算盘子8g药材合并,加水煎煮两次,第一次加水为药材重量的8倍量,煎煮1h,第二次加水为药材重量的6倍量,煎煮1h,合并煎液,0.07MPa、60-70℃下减压浓缩至65℃时相对密度为1.10,加95%(v/v)乙醇使含醇量达85%(v/v),搅拌,静置24小时,滤液减压回收乙醇并浓缩,滤液在0.07MPa、65℃条件下减压浓缩成至65℃时相对密度为1.30,喷雾干燥(条件为进风温度为120℃,出风温度为100℃,物料温度为90℃,雾化压力为0.4兆帕,喷雾速度为10ml/s。),加入淀粉,混合均匀,用适量80%(v/v)乙醇润湿,制软材,过30目筛制粒,于70~80℃干燥,用60目筛整粒,压片,包糖衣,分装,外包装,送检合格,得片剂。
实施例2:取秋木瓜12g、草石蚕8g、三股筋14g、水栀根12g、野藿香10g、假蒟果穗16g、猫儿屎8g、闹狗药12g、佛葵14g、定心散12g、山蒟8g、翼首草10g、风箱树根14g、千金藤12g、算盘子8g药材合并,加水煎煮两次,第一次加水为药材重量的10倍量,煎煮1.5h,第二次加水为药材重量的8倍量,煎煮1.5h,合并煎液,0.07MPa、60-70℃下减压浓缩至65℃时相对密度为1.15,加95%(v/v)乙醇使含醇量达75%(v/v),搅拌,静置24小时,滤液减压回收乙醇并浓缩,滤液在0.07MPa、65℃条件下减压浓缩成至65℃时相对密度为1.25,喷雾干燥(条件为进风温度为100℃,出风温度为80℃,物料温度为80℃,雾化压力为0.2兆帕,喷雾速度为5ml/s。),加入糊精等,干法制粒,过60目筛,装入1号胶囊即可得胶囊剂。
实施例3:取秋木瓜12g、草石蚕8g、三股筋14g、水栀根12g、野藿香10g、假蒟果穗16g、猫儿屎8g、闹狗药12g、佛葵14g、定心散12g、山蒟8g、翼首草10g、风箱树根14g、千金藤12g、算盘子8g药材合并,加水煎煮两次,第一次加水为药材重量的12倍量,煎煮2h,第二次加水为药材重量的10倍量,煎煮2h,合并煎液,0.07MPa、60-70℃下减压浓缩至65℃时相对密度为1.15,加95%(v/v)乙醇使含醇量达75%(v/v),搅拌,静置24小时,滤液减压回收乙醇并浓缩,滤液在0.07MPa、65℃条件下减压浓缩成至65℃时相对密度为1.25,喷雾干燥(条件为进风温度为110℃,出风温度为85℃,物料温度为85℃,雾化压力为0.3兆帕,喷雾速度为7.5ml/s。),加入上述β-环糊精包合物,粉碎,再加入适当乳糖,用适量80%(v/v)乙醇润湿,制软材,过14目筛制粒,50-80℃干燥,60目整粒,得颗粒剂。
2.对实验动物的影响药效学研究
实验药物:按上述颗粒剂实施例的制备方法制备,规格:10g/支(相当于含生药20g)。
给药剂量:按大鼠体重计,灌胃低剂量、中剂量和高剂量分别为5g生药量/kg、10g生药量/kg和20g生药量/kg。
实验动物:SD清洁级大鼠60只,雄性,体重180~210g,上海斯莱克实验动物中心提供。
实验试剂:维酶素片,河北环海药业有限公司,批号20130611;水杨酸钠,江苏永华精细化学品有限公司,批号120809;95%医用酒精,南京宁试化学试剂有限公司,批号20131028;氨水,成都市科龙化工试剂厂,批号20110722;胃动素、胃泌素放免试剂盒,北京福瑞生物工程公司。
实验过程:随机将60只大鼠分为6组,分别为:空白组、模型组、维酶素组、本发明小剂量组、本发明中剂量组、本发明大剂量组,每组l0只,造模除空白组正常饲养外,其它5组采用2%水杨酸钠和30%酒精混合溶液,每日固定时间灌胃,灌胃前后禁食禁水1h,10mL/kg;大鼠自由饮用0.05%氨水;配合饥饱失常法,每进食2d,禁食1d。造模结束前随机抽取两只作胃黏膜病理组织学检查,确认出现胃黏膜腺体萎缩,肠化和不典型增生等,停止造模药物,进入治疗阶段。造模共计17周。治疗共计4周。结束后,大鼠禁食24h,1.5%戊巴比妥腹腔注射麻醉,于剑突下沿腹白线剪开一个约2.5cm的切口,小心提起胃,在幽门与十二指肠结合部用缝合线结扎,避开血管。缝合创口后送回笼中。3h后,再结扎贲门,分别剪断食道下端及十二指肠近端,摘出全胃,洗去表面血污,用滤纸吸干,置培养皿内沿胃大弯剪开胃腔,收集胃液到离心管中,以3000rpm离心20min,吸取上清液,进行胃液分析,麦特毛细管法测胃蛋白酶,结果如下:
表1本发明对胃蛋白酶影响研究(X±SD)
注:与模型组比较,*P<0.05;**P<0.01
实验结论:本发明可提高慢性萎缩性胃炎模型大鼠胃液中胃蛋白酶活性,显示出对慢性萎缩性胃炎具有一定的治疗作用。
Claims (7)
1.一种用于治疗慢性萎缩性胃炎的中药组合物,其特征在于,它由如下重量份数的原料制备得到:秋木瓜12份、草石蚕8份、三股筋14份、水栀根12份、野藿香10份、假蒟果穗16份、猫儿屎8份、闹狗药12份、佛葵14份、定心散12份、山蒟8份、翼首草10份、风箱树根14份、千金藤12份、算盘子8份。
2.根据权利要求1所述的用于治疗慢性萎缩性胃炎的中药组合物,其特征在于,所述原料经提取后添加辅料制成片剂、胶囊或颗粒剂。
3.根据权利要求2所述的用于治疗慢性萎缩性胃炎的中药组合物,其特征在于,所述辅料为糊精、乳糖、淀粉、蔗糖、葡萄糖、微晶纤维素、甘露糖、甲基纤维素、羟丙基纤维素、羧甲基纤维素和甜菊苷的一种或几种。
4.权利要求1所述的用于治疗慢性萎缩性胃炎的中药组合物,其特征在于,制备方法包括如下步骤:取药材合并,加水煎煮两次,合并煎液,减压浓缩至65℃时相对密度为1.15-1.20的浸膏,加乙醇使含醇量的体积百分比达75-85%,搅拌,静置,过滤,滤液减压浓缩至65℃时相对密度为1.25-1.30,并回收乙醇,得浓缩液,将浓缩液喷雾干燥,添加辅料制成胶囊剂、片剂、颗粒剂。
5.根据权利要求4所述的用于治疗慢性萎缩性胃炎的中药组合物,其特征在于,制备方法步骤中煎煮条件为:第一次加水为药材重量的8-12倍量,煎煮1-2h,第二次加水为药材重量的6-10倍量,煎煮1-2h。
6.根据权利要求4所述的用于治疗慢性萎缩性胃炎的中药组合物,其特征在于,制备方法步骤中喷雾干燥条件为:进风温度为100-120℃,出风温度为80-90℃,物料温度为70-90℃,雾化压力为0.2-0.4兆帕,喷雾速度为5-10ml/s。
7.权利要求1所述用于治疗慢性萎缩性胃炎的中药组合物在治疗慢性萎缩性胃炎的药物中的应用。
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