CN104306468A - Ointment for treating squamous keratotic type beriberi and preparing method thereof - Google Patents

Ointment for treating squamous keratotic type beriberi and preparing method thereof Download PDF

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Publication number
CN104306468A
CN104306468A CN201410501822.8A CN201410501822A CN104306468A CN 104306468 A CN104306468 A CN 104306468A CN 201410501822 A CN201410501822 A CN 201410501822A CN 104306468 A CN104306468 A CN 104306468A
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parts
ointment
keratotic
type beriberi
squamous
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王纬
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/234—Cnidium (snowparsley)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
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  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
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Abstract

Ointment for treating squamous keratotic type beriberi and a preparing method thereof are disclosed. The squamous keratotic type beriberi is commonly seen on heel and foot borders, and has symptoms comprising hyperkeratosis, dryness, roughness, desquamation and pale red bases. Usually only one foot is attacked by the squamous keratotic type beriberi, and two feet can also be attacked by the squamous keratotic type beriberi. The ointment is prepared from following raw materials by weight: 10-15 parts of fruit of common cnidium, 10-15 parts of ocimum basilicum, 6-9 parts of fructus forsythiae, 9-12 parts of winter jasmine leaf, 12-18 parts of poria cocos wolff, 8-10 parts of taxillus chinensis, 6-9 parts of cimicifuga rhizome, 8-12 parts of octacosanol, 80-100 parts of polyethylene glycol, 2-4 parts of salicylic acid, 10-15 parts of fucoidan and 40-50 parts of deionized water. The ointment is prepared by compounding the medicines in the formula and has significant treating effects for the squamous keratotic type beriberi.

Description

A kind of ointment machin its preparation method for the treatment of squama keratinization type beriberi
Technical field
The invention belongs to Chinese medicine external field, be specially a kind of ointment machin its preparation method for the treatment of squama keratinization type beriberi.
Background technology
Beriberi is a kind of extremely common fungal infection dermatoses.In adult, the people of 70-80% has beriberi, and just weight is different.Be everlasting and increase the weight of summer, winter alleviates, and also has people not heal all the year round.
Squama keratinization type beriberi is apt to occur in heel, sufficient edge.Show as hyperkeratosis, dry, coarse, desquamation, substrate is light red.Many monopodias occur, and also can all involve by biped.Conscious pruritus is comparatively light, pain of often chapping winter.Because fungal infection causes xerosis cutis, cutin slightly thick, desquamation, easily chap.This type is without vesicle and suppuration, and the course of disease is slow, and how not healing, Most patients is transformed by erosive type, vesicle throughout the year.
Conventional Therapeutic Method:
One: compound benzoic acid cream or replace external with salicylate compound ethanol, sooner or later each once, or use the foot with skin repair function peaceful.With plastic sheeting wrapping after best coating, make medicine immerse pachydermia, be convenient to pachydermia and strip off, or with CHENXIANG cold foot foot bath.
Two: white Flos Impatientis 30 grams, Fructus Gleditsia 30 grams, 15 grams, Pericarpium Zanthoxyli, optional-kind, put into half jin of vinegar, soak after one day, in foot bath 20 minutes just before going to bed every night.Continuous treatment 7 days, diagonalization type has good effect.Or directly smear the clean cream of foot.
Three: use antifungal drug, also can use Chinese medicine decocting soup washout.
Summary of the invention
The object of this invention is to provide the ointment machin its preparation method that a kind of curative effect is given prominence to, had no side effect, technique simply treats squama keratinization type beriberi.
The present invention treats the ointment of squama keratinization type beriberi; Be made up of the raw material of following parts by weight: Fructus Cnidii 10 ~ 15 parts, Herba Ocimi (Herba Ocimi Pilosi) 10 ~ 15 parts, Fructus Forsythiae 6 ~ 9 parts, Folium Jasmini Nudiflori 9 ~ 12 parts, 12 ~ 18 parts, Poria, Herba Taxilli 8 ~ 10 parts, Rhizoma Cimicifugae 6 ~ 9 parts, octacosanol 8 ~ 12 parts, Polyethylene Glycol 80 ~ 100 parts, salicylic acid 2 ~ 4 parts, sulfated fucan 10 ~ 15 parts, deionized water 40 ~ 50 parts are made.
As optimization, the ointment of this treatment squama keratinization type beriberi; Be made up of the raw material of following parts by weight: Fructus Cnidii 10 parts, Herba Ocimi (Herba Ocimi Pilosi) 10 parts, Fructus Forsythiae 7 parts, Folium Jasmini Nudiflori 10 parts, 13 parts, Poria, Herba Taxilli 8 parts, Rhizoma Cimicifugae 8 parts, octacosanol 10 parts, Polyethylene Glycol 90 parts, salicylic acid 2.5 parts, sulfated fucan 12 parts, deionized water 45 grams.
Prepare the method for this treatment squama keratinization type beriberi ointment; Comprise the following steps:
A, the Fructus Cnidii of affiliated weight fraction, Herba Ocimi (Herba Ocimi Pilosi), Fructus Forsythiae, Folium Jasmini Nudiflori, Poria, Herba Taxilli, Rhizoma Cimicifugae are ground into respectively the powder of more than 300 orders, then mix homogeneously;
B, the deionized water of described parts by weight is heated to 75 DEG C ~ 80 DEG C, then adds the octacosanol of described parts by weight, Polyethylene Glycol, salicylic acid, sulfated fucan, stir;
C, by the mixed powder in step a, join in step b in mixture, under 75 DEG C ~ 80 DEG C conditions, stir, cool 48 hours and get final product.
Fructus Cnidii warming the kidney to invigorate YANG in this treatment squama keratinization type beriberi ointment formula, dampness, dispels the wind, parasite killing.Herba Ocimi (Herba Ocimi Pilosi) has dispelling wind circulation of qi promoting, and removing dampness helps digestion, the function of invigorating blood circulation, detoxifying.Fructus Forsythiae has the effects such as heat clearing away, removing toxic substances, eliminating stagnation evacuation of pus.Folium Jasmini Nudiflori controls toxic swelling malignant boil, traumatic injury, wound hemorrhage.Poria has promoting diuresis to eliminate damp pathogen, spleen invigorating, the effect of calming the nerves.Herba Taxilli invigorating the liver and kidney, bone and muscle strengthening, except rheumatism, the meridian dredging, beneficial blood, antiabortive.Rhizoma Cimicifugae yang invigorating, delivers, rash, removing toxic substances.Octacosanol has old metabolism ratio, reduces muscle friction, thus reaches effects such as reducing necessary oxygen demand, improvement response time, elimination myalgia.Polyethylene Glycol is nontoxic, nonirritant, has good water solublity, and has good intermiscibility with many organic matter components.Salicylic acid, molecular formula is C7H6O3, is plant extract of willow bark, is a kind of natural antibiotic medicine.Sulfated fucan has all multiactions such as the effect of anticoagulating and lowering blood fat, heavy metal detoxification and AntiHIV1 RT activity in medical.Drug regimen in above formula makes ointment, and treatment squama keratinization type beriberi effect is very outstanding.
Pertinent clinical data is as follows:
1. physical data: squama keratinization type beriberi patient is totally 566 examples, wherein man 392 example, female 174 example; 12 ~ 68 years old age, average 38.0 years old; The course of disease 1 week ~ 10 years.Be divided into two groups for the treatment of group 300 people, matched group 266 people.
2. diagnostic criteria: squama keratinization type: symptom is vola, sufficient edge, heel portion skin toe thicken, coarse, desquamation, and squama slabbing or little point-like, come off repeatedly.Between search toe in winter seam there is crack in skin, and summer produces vesicle, has pain.
3. Therapeutic Method: treatment group, adopts the embodiment of the present invention 1 Chinese medicinal ointment, is coated onto affected part, every day 2 times, 4 days courses for the treatment of after foot bath.Matched group, adopts daktarin, is coated onto affected part, every day 2 times, 4 days courses for the treatment of after foot bath.Observe the curative effect after the course for the treatment of.
4. efficacy evaluation: recovery from illness: skin lesion disappears, subjective symptoms disappears, selective examination negative fungal examination.Effective: skin lesion disappears more than 40%, and subjective symptoms obviously alleviates.Invalid: skin lesion disappears and is less than 40%, subjective symptoms is without being clearly better, and fungus microscope examination is positive.
 
Detailed description of the invention
The invention will be further described for embodiment plan given below; but can not be interpreted as it is limiting the scope of the invention; those skilled in the art to nonessential improvement and adjustment more of the present invention, still belong to protection scope of the present invention according to content of the present invention.
Embodiment 1:
A, get Fructus Cnidii 10 grams, powder that Herba Ocimi (Herba Ocimi Pilosi) 10 grams, Fructus Forsythiae 7 grams, Folium Jasmini Nudiflori 10 grams, 13 grams, Poria, Herba Taxilli 8 grams, Rhizoma Cimicifugae 8 grams are ground into more than 300 orders respectively, then mix homogeneously;
B, remove ionized water 45 grams and be heated to 75 DEG C ~ 80 DEG C, then add octacosanol 10 grams, Polyethylene Glycol 90 grams, salicylic acid 2.5 grams, sulfated fucan 12 grams stir;
C, by the mixed powder in step a, join in step b in mixture, under 75 DEG C ~ 80 DEG C conditions, stir, cool 48 hours and get final product.
Embodiment 2:
A, get Fructus Cnidii 10 grams, powder that Herba Ocimi (Herba Ocimi Pilosi) 10 grams, Fructus Forsythiae 6 grams, Folium Jasmini Nudiflori 9 grams, 12 grams, Poria, Herba Taxilli 8 grams, Rhizoma Cimicifugae 6 grams are ground into more than 300 orders respectively, then mix homogeneously;
B, remove ionized water 40 grams and be heated to 75 DEG C ~ 80 DEG C, then add octacosanol 8 grams, Polyethylene Glycol 80 grams, salicylic acid 2 grams, sulfated fucan 10 grams stir;
C, by the mixed powder in step a, join in step b in mixture, under 75 DEG C ~ 80 DEG C conditions, stir, cool 48 hours and get final product.
Embodiment 3:
A, get Fructus Cnidii 15 grams, powder that Herba Ocimi (Herba Ocimi Pilosi) 15 grams, Fructus Forsythiae 9 grams, Folium Jasmini Nudiflori 12 grams, 18 grams, Poria, Herba Taxilli 10 grams, Rhizoma Cimicifugae 9 grams are ground into more than 300 orders respectively, then mix homogeneously;
B, remove ionized water 50 grams and be heated to 75 DEG C ~ 80 DEG C, then add octacosanol 12 grams, Polyethylene Glycol 100 grams, salicylic acid 4 grams, sulfated fucan 15 grams stir;
C, by the mixed powder in step a, join in step b in mixture, under 75 DEG C ~ 80 DEG C conditions, stir, cool 48 hours and get final product.

Claims (3)

1. treat the ointment of squama keratinization type beriberi for one kind; It is characterized in that by the raw material of following parts by weight: Fructus Cnidii 10 ~ 15 parts, Herba Ocimi (Herba Ocimi Pilosi) 10 ~ 15 parts, Fructus Forsythiae 6 ~ 9 parts, Folium Jasmini Nudiflori 9 ~ 12 parts, 12 ~ 18 parts, Poria, Herba Taxilli 8 ~ 10 parts, Rhizoma Cimicifugae 6 ~ 9 parts, octacosanol 8 ~ 12 parts, Polyethylene Glycol 80 ~ 100 parts, salicylic acid 2 ~ 4 parts, sulfated fucan 10 ~ 15 parts, deionized water 40 ~ 50 are made.
2. the ointment for the treatment of squama keratinization type beriberi according to claim 1; It is characterized in that being made up of the raw material of following parts by weight: Fructus Cnidii 10 parts, Herba Ocimi (Herba Ocimi Pilosi) 10 parts, Fructus Forsythiae 7 parts, Folium Jasmini Nudiflori 10 parts, 13 parts, Poria, Herba Taxilli 8 parts, Rhizoma Cimicifugae 8 parts, octacosanol 10 parts, Polyethylene Glycol 90 parts, salicylic acid 2.5 parts, sulfated fucan 12 parts, deionized water 45 are made.
3. prepare the method for the treatment of squama keratinization type beriberi ointment described in claim 1 for one kind; It is characterized in that comprising the following steps:
A, the Fructus Cnidii of affiliated weight fraction, Herba Ocimi (Herba Ocimi Pilosi), Fructus Forsythiae, Folium Jasmini Nudiflori, Poria, Herba Taxilli, Rhizoma Cimicifugae are ground into respectively the powder of more than 300 orders, then mix homogeneously;
B, the deionized water of described parts by weight is heated to 75 DEG C ~ 80 DEG C, then adds the octacosanol of described parts by weight, Polyethylene Glycol, salicylic acid, sulfated fucan, stir;
C, by the mixed powder in step a, join in step b in mixture, under 75 DEG C ~ 80 DEG C conditions, stir, cool 48 hours and get final product.
CN201410501822.8A 2014-09-27 2014-09-27 Ointment for treating squamous keratotic type beriberi and preparing method thereof Pending CN104306468A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106109870A (en) * 2016-07-27 2016-11-16 桐城市泰安中药材种植专业合作社 A kind of Chinese medicine treating squama type tinea pedis

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1814004A (en) * 2005-11-28 2006-08-09 田成元 Medicine for treating skin inflammation
CN102205074A (en) * 2010-06-25 2011-10-05 郭景善 Chinese medicinal composition and application thereof
CN102233085A (en) * 2010-10-01 2011-11-09 刘叙光 External application drug for treating skin diseases

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1814004A (en) * 2005-11-28 2006-08-09 田成元 Medicine for treating skin inflammation
CN102205074A (en) * 2010-06-25 2011-10-05 郭景善 Chinese medicinal composition and application thereof
CN102233085A (en) * 2010-10-01 2011-11-09 刘叙光 External application drug for treating skin diseases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
桂承会: "蛇床子的疗效及其剂形改进工作的介绍", 《中药通报》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106109870A (en) * 2016-07-27 2016-11-16 桐城市泰安中药材种植专业合作社 A kind of Chinese medicine treating squama type tinea pedis

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Application publication date: 20150128