CN104306467B - A kind of medicament treating hyperlipidemia - Google Patents

A kind of medicament treating hyperlipidemia Download PDF

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Publication number
CN104306467B
CN104306467B CN201410635341.6A CN201410635341A CN104306467B CN 104306467 B CN104306467 B CN 104306467B CN 201410635341 A CN201410635341 A CN 201410635341A CN 104306467 B CN104306467 B CN 104306467B
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grams
parts
herba
folium
fructus
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CN104306467A (en
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徐玉英
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Xu Yuying
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/486—Millettia
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A61K36/575—Magnolia
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/85—Verbenaceae (Verbena family)
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    • A61K36/88—Liliopsida (monocotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969—Polygonatum (Solomon's seal)
    • A—HUMAN NECESSITIES
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches

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Abstract

The present invention relates to a kind of medicament treating hyperlipidemia, it comprises the materials such as storage, Poria, Cortex Cinnamomi.Medicament of the present invention interacts, synergism, uses replenishing QI to invigorate the spleen Zhi Qiben, and blood stasis dispelling reduces phlegm and controls its mark, reaches the effect for the treatment of both the principal and secondary aspects of a disease.

Description

A kind of medicament treating hyperlipidemia
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of medicament treating hyperlipidemia.
Background technology
Hyperlipidemia refers to a kind of disease that one or more component contents in blood plasma lipide are abnormal, is due in human body Caused by lipid metabolic disorder, it is that formation arterial blood is atherosis, one of Major Risk Factors causing cardiovascular and cerebrovascular disease, at present Western medicine hyperlipemia curative effect is not ideal enough, and side effect is big.
Summary of the invention
It is an object of the invention to provide a kind of medicament treating hyperlipidemia.
In order to realize the purpose of the present invention, the present invention provides a kind of medicament treating hyperlipidemia, and it comprises following weight The material of part: store 100-150 part, Poria 100-200 part and Cortex Cinnamomi 100-300 part.
Preferably, the medicament for the treatment of hyperlipidemia of the present invention comprises the material of following weight portion: store 120 parts, 180 parts of Poria and Cortex Cinnamomi 200 parts.
It is highly preferred that the medicament for the treatment of hyperlipidemia of the present invention also comprises the material of following weight portion: fragrant plant read by rice 100-300 part, water hair penetrate 200-300 part, Folium Capsici 100-200 part, Chinese enkianthus 100-200 part, Folium Pruni pseudocerasi 100-150 part, sun Fructus Persicae 150-200 part, Herba Botrychii 100-150 part, Fructus Crataegi 50-100 part, Viola arcuata 50-150 part, plumage split in Microsorium Link 50-100 part, chicken Gold 100-200 part, fernleaf hedge bamboo 50-100 part, Rhizoma Polygonati Odorati 50-150 part, Folium Styracis Suberifoliae 50-100 part, Cortex Magnoliae Officinalis 100-200 part, Herba Silenes conoideae 50- 150 parts, Radix Seu Caulis Mucunae Sempervirentis 100-300 part, Herba Blumeae Laciniatae 100-200 part, catechu 100-300 part, Herba Ixeritis Denticulatae 100-200 part, Fructus Elaeagni Angustifoliae 100- 200 parts, Cortex Querci Mongolicae 100-200 part and Radix Glycyrrhizae 50-150 part.
Most preferably, the medicament for the treatment of hyperlipidemia of the present invention also comprises the material of following weight portion: fragrant plant read by rice 200 parts, water hair penetrate 260 parts, Folium Capsici 150 parts, Chinese enkianthus 160 parts, Folium Pruni pseudocerasi 110 parts, Fructus Averrhoae Carambolae 170 parts, Herba Botrychii 110 parts, Fructus Crataegi 80 parts, Viola arcuata 100 parts, plumage split Microsorium Link 90 parts, Endothelium Corneum Gigeriae Galli 150 parts, fernleaf hedge bamboo 90 parts, Rhizoma Polygonati Odorati 100 parts, Folium Styracis Suberifoliae 70 parts, Cortex Magnoliae Officinalis 110 parts, Herba Silenes conoideae 90 parts, Radix Seu Caulis Mucunae Sempervirentis 200 parts, the Herba Blumeae Laciniatae 170 parts, 200 parts of catechu, Herba Ixeritis Denticulatae 110 parts, 140 parts of Fructus Elaeagni Angustifoliae, Cortex Querci Mongolicae 110 parts and 100 parts of Radix Glycyrrhizae.
Preferably, described medicament can be tablet, dispersible tablet, capsule, soft capsule, decoction or patch.
The present invention also provides for compositions purposes in the medicament of preparation treatment hyperlipidemia, and described compositions comprises following The material of weight portion: store 100-150 part, Poria 100-200 part and Cortex Cinnamomi 100-300 part.
Preferably, described compositions comprises the material of following weight portion: store 120 parts, 180 parts of Poria and Cortex Cinnamomi 200 parts.
It is highly preferred that described compositions also comprises the material of following weight portion: fragrant plant 100-300 part read by rice, water hair penetrates 200- 300 parts, Folium Capsici 100-200 part, Chinese enkianthus 100-200 part, Folium Pruni pseudocerasi 100-150 part, Fructus Averrhoae Carambolae 150-200 part, Herba Botrychii 100-150 part, Fructus Crataegi 50-100 part, Viola arcuata 50-150 part, plumage split Microsorium Link 50-100 part, Endothelium Corneum Gigeriae Galli 100-200 part, fernleaf hedge bamboo 50-100 part, Rhizoma Polygonati Odorati 50-150 part, Folium Styracis Suberifoliae 50-100 part, Cortex Magnoliae Officinalis 100-200 part, Herba Silenes conoideae 50-150 part, Radix Seu Caulis Mucunae Sempervirentis 100-300 Part, Herba Blumeae Laciniatae 100-200 part, catechu 100-300 part, Herba Ixeritis Denticulatae 100-200 part, Fructus Elaeagni Angustifoliae 100-200 part, Cortex Querci Mongolicae 100-200 Part and Radix Glycyrrhizae 50-150 part.
Most preferably, described compositions also comprises the material of following weight portion: fragrant plant 200 parts read by rice, water hair penetrate 260 parts, peppery 150 parts of green pepper leaf, Chinese enkianthus 160 parts, Folium Pruni pseudocerasi 110 parts, Fructus Averrhoae Carambolae 170 parts, Herba Botrychii 110 parts, Fructus Crataegi 80 parts, Viola arcuata 100 parts, Plumage split Microsorium Link 90 parts, Endothelium Corneum Gigeriae Galli 150 parts, fernleaf hedge bamboo 90 parts, Rhizoma Polygonati Odorati 100 parts, Folium Styracis Suberifoliae 70 parts, Cortex Magnoliae Officinalis 110 parts, Herba Silenes conoideae 90 parts, Radix Seu Caulis Mucunae Sempervirentis 200 parts, the Herba Blumeae Laciniatae 170 parts, 200 parts of catechu, Herba Ixeritis Denticulatae 110 parts, 140 parts of Fructus Elaeagni Angustifoliae, Cortex Querci Mongolicae 110 parts and Radix Glycyrrhizae 100 Part.
Preferably, described medicament can be tablet, dispersible tablet, capsule, soft capsule, decoction or patch.
In the present compositions, fragrant plant read by rice and water hair penetrates replenishing QI to invigorate the spleen, promoting the circulation of QI and reducing phlegm, for monarch drug；Storage, Poria, Cortex Cinnamomi, Folium Capsici, Chinese enkianthus, Folium Pruni pseudocerasi, Fructus Averrhoae Carambolae, Herba Botrychii, Fructus Crataegi, Viola arcuata promoting flow of QI and blood, removing food stagnancy blood stasis dispelling, ministerial drug；Plumage splits Microsorium Link, Endothelium Corneum Gigeriae Galli, fernleaf hedge bamboo, Rhizoma Polygonati Odorati, Folium Styracis Suberifoliae, Cortex Magnoliae Officinalis, Herba Silenes conoideae, Radix Seu Caulis Mucunae Sempervirentis, the Herba Blumeae Laciniatae, catechu, Herba Ixeritis Denticulatae, Fructus Elaeagni Angustifoliae, Querci Mongolicae Picoliters is clear, dampness removing, change are turbid, and nourishing liver, invigorating kidney, for adjuvant drug；Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, for making medicine.
Medicament of the present invention interacts, synergism, uses replenishing QI to invigorate the spleen Zhi Qiben, and blood stasis dispelling reduces phlegm and controls its mark, Reach the effect for the treatment of both the principal and secondary aspects of a disease.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustrating The present invention rather than limitation of the present invention.The simple modifications that the present invention is carried out by the essence according to the present invention broadly falls into the present invention Claimed scope.Unless otherwise stated, the percent in the present invention is percetage by weight.
The decoction of the embodiment present invention
1) weighing storage 120 grams, 180 grams of Poria and Cortex Cinnamomi 200 grams, add 2000 milliliters of dehydrated alcohol, reflux, extract, 3 is little Time, it is cooled to room temperature, adding water to alcohol content is 60 volume %, closes and stands 24 hours, filters, and the ethanol reclaimed in filtrate obtains To extracting solution 1；
2) weigh rice read fragrant plant 200 grams, water hair penetrate 260 grams, Folium Capsici 150 grams, Chinese enkianthus 160 grams, Folium Pruni pseudocerasi 110 grams, sun Fructus Persicae 170 grams, Herba Botrychii 110 grams, Fructus Crataegi 80 grams, Viola arcuata 100 grams, plumage split Microsorium Link 90 grams, Endothelium Corneum Gigeriae Galli 150 grams, fernleaf hedge bamboo 90 grams, Rhizoma Polygonati Odorati 100 grams, Folium Styracis Suberifoliae 70 grams, Cortex Magnoliae Officinalis 110 grams, Herba Silenes conoideae 90 grams, Radix Seu Caulis Mucunae Sempervirentis 200 grams, the Herba Blumeae Laciniatae 170 grams, 200 grams of catechu, hardship Mai dish 110 grams, 140 grams of Fructus Elaeagni Angustifoliae, Cortex Querci Mongolicae 110 grams and 100 grams of Radix Glycyrrhizae, add 30000 milliliters of water, heats under conditions of backflow 3 hours, being cooled to room temperature, adding dehydrated alcohol to alcohol content is 75 volume %, closes and stands 24 hours, filters, and reclaims filtrate In ethanol obtain extracting solution 2；
3) united extraction liquid 1 and 2, is concentrated into 10000 milliliters, to obtain the decoction of the present invention.
Experimental example
Diagnostic criteria reference " new Chinese medicine guideline of clinical investigations " (Ministry of Health of the People's Republic of China. new Chinese medicine Guideline of clinical investigations (second volume) [S]. Beijing: China Medical Science Press, 1995；171-174. relevant high blood in) The diagnostic criteria of fat disease is formulated, and is i.e. in the case of normal diet, detects the fasting blood lipid level of 12-24 hour, and at one week Interior detection 2 times, if serum cholesterol (TC) still >=5.7mmol/L, or TG (TG) >=1.7mmol/L, or high density fat Protein cholesterol (HDL-C)≤1.04mmol/L (men and women is same), meets above-mentioned standard any one standard person and can be diagnosed as height Blood fat disease.For MethodsThe cases enrolled, all person's cases all get rid of serious heart and brain kidney and metabolic disease.
Physical data
Select patient's totally 75 example that in May ,-2014 in January, 2013, the court accepted for medical treatment, be divided into treatment group and matched group, treatment group 40 examples, the maleest 29 examples, female 11 example, (53.8 ± 10.3) year mean age, average course of disease (6.8 ± 3.12) year.Matched group 35 Example, the maleest 26 examples, female 9 example, (55.3 ± 10.8) year mean age, average course of disease (6.6 ± 3.23) year, 2 groups of sexes, years Before age, the course of disease and treatment, blood lipid level compares, and no significant difference (P ＞ 0.05) has comparability.
Treatment group uses the decoction of preparation in embodiment to treat, every day 1 time, the most oral 100 milliliters.Matched group Oral Max EPA capsule (is produced 0.45g/ grain by Beijing Changcheng Pharmaceutical Factory), each 4, three times a day.2 groups all being January 1 treatment Journey, checks the indexs such as T-CHOL (TC), TG (TG), HDL-C (HDL-C), uses after terminating the course for the treatment of Statistical procedures therapeutic outcome.
Curative effect judging standard
Reference " new Chinese medicine guideline of clinical investigations " (Ministry of Health of the People's Republic of China. new Chinese medicine clinical research Guideline (second volume) [S]. Beijing: China Medical Science Press, 1995；About the treatment of hyperlipidemia in 171-174.) Criterion standard is drafted.
Clinic control: blood fat indices recovers normal.Effective: lipids detection reaches following 1 person, TC declines >= 20%, TG decline >=40%, HDL-C rising >=0.26mmol/L；Effective: lipids detection reaches following 1 person, TC declines >= 10% but ＜ 40%, TG decline >=20% but ＜ 40%, HDL-C rising >=0.104mmol/L but ＜ 0.26mmol/L；Invalid: Lipids detection is not up to above-mentioned standard.
Result
Two groups of comparitive study, treatment group clinic control 10 example, effective 11 examples, effective 13 examples, invalid 6 examples, total effective rate 85%.Matched group clinic control 2 example, effective 6 examples, effective 12 examples, invalid 15 examples, total effective rate 57.14%, 2 groups of total effective rates Comparison therapy group is better than matched group, and difference has significant (P ＜ 0.05).2 groups all have no adverse reaction.
Before and after two groups of treatments, the change of blood fat indices is compared, and is shown in Table 1.After treatment, two groups of TC, TG all have clear improvement, but Treatment group is better than matched group, and two groups are compared, and difference is very significant (P ＜ 0.01), and the improvement for the treatment of group HDL-C The most more apparent, compare with matched group, difference is very significant (P ＜ 0.01).
Before and after the treatment of 12 groups of table, blood fat indices (mmol/L) change is compared
Note: compare with before treatment, * P ＜ 0.05, * * P ＜ 0.01.Compare with matched group, Δ P ＜ 0.01.

Claims (1)

1. the medicament treating hyperlipidemia, it is characterised in that it is made by following method: 1) weigh storage 120 grams, Fu Siberian cocklebur 180 grams and Cortex Cinnamomi 200 grams, add 2000 milliliters of dehydrated alcohol, reflux, extract, 3 hours, is cooled to room temperature, adds water and contains to alcohol Amount is 60 volume %, closes and stands 24 hours, filters, and the ethanol reclaimed in filtrate obtains extracting solution 1；
2) weigh rice read fragrant plant 200 grams, water hair penetrate 260 grams, Folium Capsici 150 grams, Chinese enkianthus 160 grams, Folium Pruni pseudocerasi 110 grams, Fructus Averrhoae Carambolae 170 Gram, Herba Botrychii 110 grams, Fructus Crataegi 80 grams, Viola arcuata 100 grams, plumage split Microsorium Link 90 grams, Endothelium Corneum Gigeriae Galli 150 grams, fernleaf hedge bamboo 90 grams, Rhizoma Polygonati Odorati 100 grams, Folium Styracis Suberifoliae 70 grams, Cortex Magnoliae Officinalis 110 grams, Herba Silenes conoideae 90 grams, Radix Seu Caulis Mucunae Sempervirentis 200 grams, the Herba Blumeae Laciniatae 170 grams, 200 grams of catechu, Herba Ixeritis Denticulatae 110 grams, 140 grams of Fructus Elaeagni Angustifoliae, Cortex Querci Mongolicae 110 grams and 100 grams of Radix Glycyrrhizae, add 30000 milliliters of water, heats 3 little under conditions of backflow Time, it is cooled to room temperature, adding dehydrated alcohol to alcohol content is 75 volume %, closes and stands 24 hours, filters, and reclaims in filtrate Ethanol obtains extracting solution 2；
3) merge described extracting solution 1 and 2, be concentrated into 10000 milliliters, to obtain final product.
CN201410635341.6A 2014-11-11 2014-11-11 A kind of medicament treating hyperlipidemia Expired - Fee Related CN104306467B (en)

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