CN104306458B - A preparation for treating visceral white-spot disease of pseudosciaena crocea and uses thereof - Google Patents
A preparation for treating visceral white-spot disease of pseudosciaena crocea and uses thereof Download PDFInfo
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- CN104306458B CN104306458B CN201410501361.4A CN201410501361A CN104306458B CN 104306458 B CN104306458 B CN 104306458B CN 201410501361 A CN201410501361 A CN 201410501361A CN 104306458 B CN104306458 B CN 104306458B
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- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- 241001596950 Larimichthys crocea Species 0.000 title abstract 5
- 206010027982 Morphoea Diseases 0.000 title abstract 3
- 230000009278 visceral effect Effects 0.000 title abstract 3
- 241000251468 Actinopterygii Species 0.000 claims abstract description 26
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 22
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229960003722 doxycycline Drugs 0.000 claims abstract description 14
- XQTWDDCIUJNLTR-CVHRZJFOSA-N doxycycline monohydrate Chemical compound O.O=C1C2=C(O)C=CC=C2[C@H](C)[C@@H]2C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@@H]1[C@H]2O XQTWDDCIUJNLTR-CVHRZJFOSA-N 0.000 claims abstract description 14
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims abstract description 12
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims abstract description 12
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims abstract description 12
- 239000011719 vitamin A Substances 0.000 claims abstract description 12
- 235000019155 vitamin A Nutrition 0.000 claims abstract description 12
- 229940045997 vitamin a Drugs 0.000 claims abstract description 12
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 11
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 11
- 239000011718 vitamin C Substances 0.000 claims abstract description 11
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 7
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 7
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 7
- 229940046009 vitamin E Drugs 0.000 claims abstract description 7
- 239000011709 vitamin E Substances 0.000 claims abstract description 7
- 241000005787 Cistanche Species 0.000 claims description 25
- 210000001835 viscera Anatomy 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 9
- 238000000605 extraction Methods 0.000 claims description 7
- 229940088594 vitamin Drugs 0.000 claims description 7
- 229930003231 vitamin Natural products 0.000 claims description 7
- 235000013343 vitamin Nutrition 0.000 claims description 7
- 239000011782 vitamin Substances 0.000 claims description 7
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 241000006479 Cyme Species 0.000 abstract description 19
- 150000001875 compounds Chemical class 0.000 abstract description 18
- 230000000694 effects Effects 0.000 abstract description 8
- 206010059866 Drug resistance Diseases 0.000 abstract description 4
- 230000004083 survival effect Effects 0.000 abstract description 4
- 230000002195 synergetic effect Effects 0.000 abstract description 3
- 241000336291 Cistanche deserticola Species 0.000 abstract description 2
- 230000002019 anti-mutation Effects 0.000 abstract 1
- 235000019733 Fish meal Nutrition 0.000 description 4
- 239000004467 fishmeal Substances 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 206010006100 Bradykinesia Diseases 0.000 description 1
- 241001597062 Channa argus Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000006083 Hypokinesia Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000004596 appetite loss Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000007365 immunoregulation Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 235000021266 loss of appetite Nutrition 0.000 description 1
- 208000019017 loss of appetite Diseases 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/64—Orobanchaceae (Broom-rape family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Natural Medicines & Medicinal Plants (AREA)
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- Epidemiology (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
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- Alternative & Traditional Medicine (AREA)
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Abstract
The invention relates to a preparation for treating visceral white-spot disease of pseudosciaena crocea and uses thereof, and belongs to the technical field of fishery. The preparation and the uses thereof are characterized in that: the preparation comprises 30-40 parts of a compound cyme extract product, 20-30 parts of a cistanche deserticola extract product, 10-15 parts of doxycycline, 4-6 parts of vitamin A, 2-5 parts of vitamin E and 6-10 parts of vitamin C. According to the preparation and the uses thereof, treating effects of the preparation for the visceral white-spot disease of the pseudosciaena crocea are good, components are compatible and synergistic, and the preparation has immunity-boosting and antimutation effects, reduces drug resistance of the pseudosciaena crocea, increases the rate of survival of the pseudosciaena crocea, accelerates the growth speed, and improves quality of fish.
Description
Technical field
The invention belongs to technical field of fishery, specially a kind of preparation for treating Radix Et Rhizoma Rhei fish internal organs ichthyophthiriasises and application thereof.
Background technology
Carnis Pseudosciaenae, is one of traditional four big marine products, China coastal seas Main Commercial Fishes, containing rich in protein, micro
Element, vitamin and trace element-selenium, to have a delicate constitution and middle-aged and elderly people for, edible Channa argus can receive good dietetic therapy effect
Really, the free radical of body metabolism generation can be removed, can slow down aging.Radix Et Rhizoma Rhei fish internal organs ichthyophthiriasises Symptoms are：The ill initial stage
Sick fish body table non-evident sympton, only bradykinesia, loss of appetite, peel off upper floatation surface then, solely swims or be still in net cage bottom,
Body constitution does not almost see symptom, but increasing with the state of an illness compared with weak person's i.e. death soon, body surface, and part fish body table occurs in that white
Or faint yellow speckle；Body surface has damage and ulcer, and bleeding is rubescent, and tail fin and chin also have bleeding, rubescent, and subsequent mortality is gradually
Increase.Under the conditions of Fish intensive culture, the Fish of cultivation easily receive such environmental effects, and fish medicine is easy to produce drug resistance
Property, so as to cause Carnis Pseudosciaenae survival rate relatively low, the speed of growth is slower, the quality decline of the flesh of fish.
The content of the invention
For the problems referred to above of presence of the prior art, the present invention's is that design offer one kind treats Radix Et Rhizoma Rhei fish internal organs
The technical scheme of the preparation of ichthyophthiriasises and application thereof, its therapeutic effect to Radix Et Rhizoma Rhei fish internal organs ichthyophthiriasises is good, and mutual compatibility is not only
With synergistic function, the Drug resistance of Carnis Pseudosciaenae is also reduced, improve Carnis Pseudosciaenae survival rate, accelerate the speed of growth, improved
Flesh quality.
Described a kind of preparation for treating Radix Et Rhizoma Rhei fish internal organs ichthyophthiriasises, it is characterised in that containing compound cyme extract
30-40 parts, Herba Cistanches extract 20-30 parts, doxycycline 10-15 parts, vitamin A 4-6 parts, -5 parts of vitamin E2, vitamin
C6-10 parts；Described compound cyme extract is prepared using following methods：Compound cyme is dried, crushes, and 5-8 times is measured water
Ebuillition of heated is extracted 2-3 time, each 1-2 hours, and united extraction liquid is concentrated in vacuo, be drying to obtain compound cyme extract powder
End；Described Herba Cistanches extract is prepared using following methods：Herba Cistanches are dried, crush, and measure water ebuillition of heated for 5-8 times and extract 2-
3 times, each 1-2 hours, united extraction liquid is concentrated in vacuo, be drying to obtain Herba Cistanches extract powder.
A kind of described preparation for treating Radix Et Rhizoma Rhei fish internal organs ichthyophthiriasises, it is characterised in that 30 parts of compound cyme extract,
20 parts of Herba Cistanches extract, 10 parts of doxycycline, 4 parts of vitamin A, vitamin E2 part, 6 parts of vitamin C.
A kind of described preparation for treating Radix Et Rhizoma Rhei fish internal organs ichthyophthiriasises, it is characterised in that 40 parts of compound cyme extract,
30 parts of Herba Cistanches extract, 12 parts of doxycycline, 6 parts of vitamin A, 5 parts of Vitamin E, 10 parts of vitamin C.
A kind of described preparation for treating Radix Et Rhizoma Rhei fish internal organs ichthyophthiriasises, it is characterised in that 35 parts of compound cyme extract,
25 parts of Herba Cistanches extract, 15 parts of doxycycline, 5 parts of vitamin A, 4 parts of Vitamin E, 8 parts of vitamin C.
Application of the described compound cyme in the preparation for preparing treatment Radix Et Rhizoma Rhei fish internal organs ichthyophthiriasises.
Application of the described Herba Cistanches in the preparation for preparing treatment Radix Et Rhizoma Rhei fish internal organs ichthyophthiriasises.
Compound cyme, perennial herb, high 50～100cm；Main root is cylindric, skin near-white；Stem four ribs of summary, many points
Branch, dredges growth rough hair；Leaf opposite, petiole 5～15mm of length；Blade is oval or narrow ellipse, minority obovate, long 3～12cm,
Wide 1.5～5.5m, tip is tapering or tail point, base portion wedge shape or wide wedge shape, full edge, above adhesion long bristles, below hair it is closeer；It is multiple
Cyme is intensive into bouquet group.Excavate when winter stem and leaf is withered, remove fibrous root and silt, be bundled into wisp, shine to shriveling, will
Top trims, and dries.Containing containing effective ingredient such as steroid, amino acidses, saponin, polysaccharide, alkaloids in its extract, have very
Strong immunoregulation effect.
Cistanche deserticola Orobanchaceae endangered species, call big rue, very little rue, Herba Cistanchess, and main product is in the Alashan League of Inner Mongolia Autonomous Region
And Xinjiang, Herba Cistanches are a kind of parasitic plants for colonizing in desert trees sacsaoul root, and nutrient and water are drawn from sacsaoul host
Part.Herba Cistanches extract has very strong antibacterial, antiinflammatory and adjusts body's immunity.
Above-mentioned a kind of preparation for treating Radix Et Rhizoma Rhei fish internal organs ichthyophthiriasises and application thereof, its treatment to Radix Et Rhizoma Rhei fish internal organs ichthyophthiriasises
Effect is good, and mutual compatibility not only has synergistic function, with enhancing immunity, antimutagenicity, also reduces Carnis Pseudosciaenae
Drug resistance, improves Carnis Pseudosciaenae survival rate, accelerates the speed of growth, improves flesh quality.
The percentage composition being related in present specification is unless otherwise indicated, other to be weight percentage.
Specific embodiment
Below by way of specific embodiment, the invention will be further described, and further illustrates the present invention with reference to the test of pesticide effectiveness
Beneficial effect.
Embodiment 1
30 parts of compound cyme extract, 20 parts of Herba Cistanches extract, 10 parts of doxycycline, 4 parts of vitamin A, vitamin
6 parts of E2 parts, vitamin C；Described compound cyme extract is prepared using following methods：Compound cyme is dried, crushes, 5-
8 times of amount water ebuillition of heated are extracted 2-3 time, each 1-2 hours, united extraction liquid, concentrated in vacuo, be drying to obtain compound cyme and carry
Take thing powder；Described Herba Cistanches extract is prepared using following methods：Herba Cistanches are dried, crush, and 5-8 times is measured water ebuillition of heated
Extract 2-3 time, each 1-2 hours, united extraction liquid is concentrated in vacuo, be drying to obtain Herba Cistanches extract powder.
The step of above-described embodiment 11）40 parts of middle compound cyme extract, 30 parts of Herba Cistanches extract, doxycycline 12
Part, 6 parts of vitamin A, 5 parts of Vitamin E, 10 parts of vitamin C；Or 35 parts of compound cyme extract, 25 parts of Herba Cistanches extract,
15 parts of doxycycline, 5 parts of vitamin A, 4 parts of Vitamin E, 8 parts of vitamin C, other all embodiments 1 can also obtain the present invention's
Technique effect.
It is according to the ratio that 1 gram is admixed per 100 grams of feedstuffs that above-mentioned preparation is direct with fish meal.
Beneficial effects of the present invention are further illustrated below in conjunction with contrast test.
Test 1：
4 groups of Carnis Pseudosciaenae with internal organs ichthyophthiriasises are selected, 10 per group, embodiment 1 is respectively adopted to be carried out according to amount of application
Process, matched group 1 is admixed for doxycycline and fed in Radix Et Rhizoma Rhei fish meal, and matched group 2 admixes Radix Et Rhizoma Rhei for compound cyme extract
Feed in fish meal, matched group 3 is admixed for Herba Cistanches extract and fed in Radix Et Rhizoma Rhei fish meal, in matched group 1-3, matched group 1-3
Middle doxycycline, compound cyme extract, the content of Herba Cistanches extract feed daily 1 time with embodiment 1, even feed 5 days.
Result of the test is shown in Table 1.
The therapeutic effect table of 1 embodiment of table, 1 pair of Carnis Pseudosciaenae with internal organs ichthyophthiriasises
| Process | Ill Carnis Pseudosciaenae number | It is effective | Effectively | It is invalid | Total effective rate（%） |
| Embodiment 1 | 10 | 9 | 1 | 0 | 100 |
| Matched group 1 | 10 | 3 | 3 | 4 | 60 |
| Matched group 2 | 10 | 2 | 5 | 3 | 70 |
| Matched group 3 | 10 | 3 | 5 | 2 | 80 |
Result of the test shows：Embodiment 1-4 has good curative effect to Radix Et Rhizoma Rhei fish internal organs ichthyophthiriasises, is above matched group 1-3,
It can thus be seen that very aobvious to the therapeutic effect of Radix Et Rhizoma Rhei fish internal organs ichthyophthiriasises using fish medicine obtained in complex preparation of the present invention
Write, each component has significant cooperative synergism effect.
Claims (4)
1. a kind of preparation for treating Radix Et Rhizoma Rhei fish internal organs ichthyophthiriasises, it is characterised in that containing Radix Cyathulae extract 30-40 parts, Herba Cistanches
Extract 20-30 parts, doxycycline 10-15 parts, vitamin A 4-6 parts, -5 parts of vitamin E2, vitamin C 6-10 parts；Described
Radix Cyathulae extract is prepared using following methods：Radix Cyathulae is dried, crushes, and 5-8 times is measured water ebuillition of heated extraction 2-3 time, every time
1-2 hours, united extraction liquid is concentrated in vacuo, be drying to obtain Radix Cyathulae extract powder；Described Herba Cistanches extract adopt with
It is prepared by lower section method：Herba Cistanches are dried, crush, and measure water ebuillition of heated for 5-8 times and extract 2-3 time, each 1-2 hours, united extraction liquid,
It is concentrated in vacuo, be drying to obtain Herba Cistanches extract powder.
2. a kind of preparation for treating Radix Et Rhizoma Rhei fish internal organs ichthyophthiriasises as claimed in claim 1, it is characterised in that Radix Cyathulae extract
30 parts, 20 parts of Herba Cistanches extract, 10 parts of doxycycline, 4 parts of vitamin A, vitamin E2 part, 6 parts of vitamin C.
3. a kind of preparation for treating Radix Et Rhizoma Rhei fish internal organs ichthyophthiriasises as claimed in claim 1, it is characterised in that Radix Cyathulae extract
40 parts, 30 parts of Herba Cistanches extract, 12 parts of doxycycline, 6 parts of vitamin A, 5 parts of Vitamin E, 10 parts of vitamin C.
4. a kind of preparation for treating Radix Et Rhizoma Rhei fish internal organs ichthyophthiriasises as claimed in claim 1, it is characterised in that Radix Cyathulae extract
35 parts, 25 parts of Herba Cistanches extract, 15 parts of doxycycline, 5 parts of vitamin A, 4 parts of Vitamin E, 8 parts of vitamin C.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410501361.4A CN104306458B (en) | 2014-09-26 | 2014-09-26 | A preparation for treating visceral white-spot disease of pseudosciaena crocea and uses thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410501361.4A CN104306458B (en) | 2014-09-26 | 2014-09-26 | A preparation for treating visceral white-spot disease of pseudosciaena crocea and uses thereof |
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| Publication Number | Publication Date |
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| CN104306458A CN104306458A (en) | 2015-01-28 |
| CN104306458B true CN104306458B (en) | 2017-04-26 |
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