CN104306402A - Traditional Chinese medicine composition for treating burn and scald infection and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating burn and scald infection and preparation method thereof Download PDFInfo
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- CN104306402A CN104306402A CN201410547254.5A CN201410547254A CN104306402A CN 104306402 A CN104306402 A CN 104306402A CN 201410547254 A CN201410547254 A CN 201410547254A CN 104306402 A CN104306402 A CN 104306402A
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A61K33/00—Medicinal preparations containing inorganic active ingredients
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
- A61K35/04—Tars; Bitumens; Mineral oils; Ammonium bituminosulfonate
- A61K35/06—Mineral oils, e.g. paraffinic oils or aromatic oils based on aromatic hydrocarbons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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Abstract
The invention relates to the technical field of burn and scald infection treatment, and particularly relates to a traditional Chinese medicine composition for treating burn and scald infection and a preparation method thereof. The preparation method comprises the following steps: mixing vaseline, egg yolk oil, sulfanilamide powder, high glucose, mercurochrome powder and borneol to prepare ointment; controlling the physicochemical environment and stirring speed in the preparation process to carry out a complicated microscopic biochemical reaction on effective ingredients in the raw materials so as to prepare the composition for removing necrotic tissue, promoting granulation, clearing heat, removing toxicity, diminishing inflammation and relieving pain. The traditional Chinese medicine composition has a remarkable treatment effect on burn and scald infectious diseases, and has the effective rate of 100 percent and cure rate of 99.13 percent.
Description
Technical field
The present invention relates to burn and scald treatment of infection technical field, especially a kind of Chinese medicine composition and preparation method thereof for the treatment of burn and scald and infecting.
Background technology
Burn and scald be thermodynamic activity in human skin, and then cause the disease of skin histology generation acute injury, be divided into burn due to hot liquid or fire, fire burn, electric injury, soup to sprinkle several classes such as burn; Primary disease is a kind of heat-flash infringement human body, rots to form to cause skin histology; Western medicine is thought: the main cause of primary disease is due to high temperature, as the scald that the contact skin-on-skin such as flame, boiling water, molten steel, steam bring; Chemical factor, as the contact such as strong acid, highly basic skin, to the burn that skin brings; Electric power factor, that brings as contact skin-on-skin such as electric shock, lightnings burns; Radiation factor, as the radiation damage that X-ray, atomic energy etc. cause skin; These factors all can cause the dermal tissue insult of local or whole property to skin, and then make skin generation degeneration, necrosis, even cause skin infection, further cause large-area skin injury, and then cause dermal tissue component structure to change, directly cause tissue destruction, afunction, reduce body immunity, then cause other diseases to produce, human life is constituted a threat to.
The pathological process of burn and scald disease, according to the situation of change of its burn and scald skin histology, can be divided into three periods: one for shock stage, is during this period within there is the 48h after burn and scald, during this period of time mainly hypovolemic shock; Two is infection periods, mostly occur this period in the 3-4 week (molten crust phase) after the 3-7 after burn and scald days (edema payoff period) and burn and scald, be by the skin the most susceptible period of burn and scald during this period of time, the most unmanageable period when being also treatment burn and scald; Three is reparation phases, and this period, its stage on opportunity was also different according to the degree varies sample of burn and scald, but has occurred the stage that skin is lived again, skin tissue cell brings back to life during this period of time.
Therefore, can draw from above-mentioned pathological analysis process, be infection period for burn and scald disease the most refractory period, has large quantifier elimination to start with from this respect for this reason and work it out research to burn and scald treatment, but all do not obtain good effect.
At present, the method that hospital treats for the medication of burn and scald infection period mainly adopts: after debridement, the therapeutic modality adopting antibacterials, Chinese herbal medicine, vaseline to carry out wound surface dressing, and after employing debridement, after the moistening ointment of outer painting, patient being placed in indoor temperature is that the therapeutic room of 25-30 DEG C carries out exposure treatment.Although burn and scald all can be treated by above-mentioned Therapeutic Method, and obtain certain effect, but its treatment cycle is long, cure rate is lower, treatment cost is higher, and very easily there is the infection of skin injury tissue over the course for the treatment of, and then cause other secondary diseases, cause the misery of patient to increase.
, vaseline is widely used as burn and scald disease treatment meanwhile, carries out vaseline and other drug to combine that to obtain the medicament for the treatment of burn and scald innumerable at present, but these technology are all difficult to reach desirable effect; For this reason, this research worker is by carrying out research and discovery to vaseline for the treatment situation of burn and scald field disease and the effective ingredient of vaseline itself, vaseline and egg oil, antiinfectious powder, high sugar, mercurochrome powder, Borneolum Syntheticum are carried out formulated in combination paste making agent, and this combination have not been reported in the prior art, and then newly select for burn and scald treatment field provides a kind of medication.
Summary of the invention
In order to solve the above-mentioned technical problem existed in prior art, the invention provides a kind of have removing the necrotic tissue and promoting granulation, heat clearing away sterilization, anti-inflammatory analgetic effect treatment burn and scald infect Chinese medicine composition, its preparation is unguentum, and provide the preparation method of unguentum of this Chinese medicine composition, its technique is simple, with low cost, medical material is easy to get, the treatment infected for treatment burn and scald is shorter for the course for the treatment of, and can be adapted to the feature of various burn and scald infected patient.
Be achieved particular by following technical scheme:
Treat burn and scald infect a Chinese medicine composition, its raw material composition (in mass parts) is egg oil 0.5-2 part, antiinfectious powder 0.2-0.7 part, high sugared 0.5-1.5 part, vaseline 2-4 part, mercurochrome powder 0.05-0.1 part, Borneolum Syntheticum 0.005-0.015 part.
Described raw material composition (in mass parts) is egg oil 0.8-1.5 part, antiinfectious powder 0.3-0.6 part, high sugared 0.8-1.1 part, vaseline 2.5-3.5 part, mercurochrome powder 0.06-0.09 part, Borneolum Syntheticum 0.009-0.013 part.
Described raw material composition (in mass parts) is egg oil 1 part, antiinfectious powder 0.5 part, high sugar 1 part, 3 parts, vaseline, 0.08 part, mercurochrome powder, Borneolum Syntheticum 0.01 part.
Described antiinfectious powder is the one in Nuo Meikang antiinfectious powder, sterilization crystallizing sulfanilamide.
Described antiinfectious powder can also be the Chinese medicinal powder with antiinflammation undertaken by plurality of Chinese composition separately or many groups are formulated.
The glucose injection that described height sugar props up for 20ml/, wherein the mass percent of glucose is 50%.
The preparation of described Chinese medicine composition is unguentum.
A kind of Chinese medicine composition for the treatment of burn and scald, its preparation method be by: get egg oil according to proportioning, the mercurochrome powder of said ratio part is added in egg oil, and adopt the mode stirred while adding, adjustment mixing speed is 40-50r/min, and control temperature is 30-40 DEG C, to be added complete after, after Keep agitation 10-15min, add antiinfectious powder wherein again, and to adjust mixing speed be 60-70r/min, after Keep agitation 10-15min, add vaseline wherein again, adjustment mixing speed is 50-60r/min, now temperature is 40-50 DEG C, after Keep agitation process 10-20min, add Borneolum Syntheticum wherein again, add the time controling of Borneolum Syntheticum at 2-3s, and to adjust mixing speed be 90-120r/min, after Keep agitation 30-50min, add high sugar more wherein, with 60-80r/min stir process 5-15min, the unguentum of the Chinese medicine composition that treatment burn and scald infects can be obtained.
Compared with prior art, technique effect of the present invention is embodied in:
1. by by vaseline and egg oil, antiinfectious powder, height sugar, mercurochrome powder, Borneolum Syntheticum formulated in combination paste making agent, and control physicochemical environment and mixing speed in process for preparation, the effective ingredient in various raw material is made to carry out complicated microcosmic biochemical reaction, and then obtain a kind of can removing the necrotic tissue and promoting granulation, heat-clearing and toxic substances removing, anti-inflammatory analgetic compositions, make the therapeutic effect that catches to burn and scald remarkable, effective percentage is 100%, and cure rate reaches 99.13%.
2. raw medicinal material of the present invention is easy to get, and treatment process steps is simple, making with low cost, and in the process that treatment burn and scald catches, the treatment cycle course for the treatment of is short, and is applicable to various burn and scald and catches, and reduces the misery of rate patient to greatest extent.
Detailed description of the invention
Below in conjunction with concrete embodiment, further restriction is done to technical scheme of the present invention, but claimed scope is not only confined to done description.
Embodiment 1
Treat the Chinese medicine composition that burn and scald infects, its raw material composition is egg oil 0.5g, antiinfectious powder 0.2g, high sugared 0.5g, vaseline 2g, mercurochrome powder 0.05g, Borneolum Syntheticum 0.005g.
Described antiinfectious powder is Nuo Meikang antiinfectious powder.
The glucose injection that described height sugar props up for 20ml/, wherein the mass percent of glucose is 50%.
The Chinese medicine composition of this treatment burn and scald, its preparation method be by: get egg oil according to proportioning, the mercurochrome powder of said ratio part is added in egg oil, and adopt the mode stirred while adding, adjustment mixing speed is 40r/min, and control temperature is 30 DEG C, to be added complete after, after Keep agitation 10min, add antiinfectious powder wherein again, and to adjust mixing speed be 60r/min, after Keep agitation 10min, add vaseline wherein again, adjustment mixing speed is 50r/min, now temperature is 40 DEG C, after Keep agitation process 10min, add Borneolum Syntheticum wherein again, add the time controling of Borneolum Syntheticum at 2s, and to adjust mixing speed be 90r/min, after Keep agitation 30min, add high sugar more wherein, with 60r/min stir process 5min, the unguentum of the Chinese medicine composition that treatment burn and scald infects can be obtained.
Embodiment 2
Treat the Chinese medicine composition that burn and scald infects, its raw material composition is egg oil 2g, antiinfectious powder 0.7g, high sugared 1.5g, vaseline 4g, mercurochrome powder 0.1g, Borneolum Syntheticum 0.015g.
Described antiinfectious powder is Nuo Meikang antiinfectious powder.
The glucose injection that described height sugar props up for 20ml/, wherein the mass percent of glucose is 50%.
The Chinese medicine composition of this treatment burn and scald, its preparation method be by: get egg oil according to proportioning, the mercurochrome powder of said ratio part is added in egg oil, and adopt the mode stirred while adding, adjustment mixing speed is 50r/min, and control temperature is 40 DEG C, to be added complete after, after Keep agitation 15min, add antiinfectious powder wherein again, and to adjust mixing speed be 70r/min, after Keep agitation 15min, add vaseline wherein again, adjustment mixing speed is 60r/min, now temperature is 50 DEG C, after Keep agitation process 20min, add Borneolum Syntheticum wherein again, add the time controling of Borneolum Syntheticum at 3s, and to adjust mixing speed be 120r/min, after Keep agitation 50min, add high sugar more wherein, with 80r/min stir process 15min, the unguentum of the Chinese medicine composition that treatment burn and scald infects can be obtained.
Embodiment 3
Treat the Chinese medicine composition that burn and scald infects, its raw material composition is egg oil 0.8g, antiinfectious powder 0.3g, high sugared 0.8g, vaseline 2.5g, mercurochrome powder 0.06g, Borneolum Syntheticum 0.009g.
Described antiinfectious powder is the Notoginseng Root that Radix Notoginseng is developed into after drying.
The glucose injection that described height sugar props up for 20ml/, wherein the mass percent of glucose is 50%.
The Chinese medicine composition of this treatment burn and scald, its preparation method be by: get egg oil according to proportioning, the mercurochrome powder of said ratio part is added in egg oil, and adopt the mode stirred while adding, adjustment mixing speed is 45r/min, and control temperature is 35 DEG C, to be added complete after, after Keep agitation 13min, add antiinfectious powder wherein again, and to adjust mixing speed be 65r/min, after Keep agitation 13min, add vaseline wherein again, adjustment mixing speed is 55r/min, now temperature is 45 DEG C, after Keep agitation process 15min, add Borneolum Syntheticum wherein again, add the time controling of Borneolum Syntheticum at 2.5s, and to adjust mixing speed be 100r/min, after Keep agitation 40min, add high sugar more wherein, with 70r/min stir process 10min, the unguentum of the Chinese medicine composition that treatment burn and scald infects can be obtained.
Embodiment 4
Treat the Chinese medicine composition that burn and scald infects, its raw material composition is egg oil 1.5g, antiinfectious powder 0.6g, high sugared 1.1g, vaseline 3.5g, mercurochrome powder 0.09g, Borneolum Syntheticum 0.013g.
Described antiinfectious powder is that Sargassum is ground into 100-120 object powder by pulverizer.
The glucose injection that described height sugar props up for 20ml/, wherein the mass percent of glucose is 50%.
The Chinese medicine composition of this treatment burn and scald, its preparation method be by: get egg oil according to proportioning, the mercurochrome powder of said ratio part is added in egg oil, and adopt the mode stirred while adding, adjustment mixing speed is 43r/min, and control temperature is 38 DEG C, to be added complete after, after Keep agitation 14min, add antiinfectious powder wherein again, and to adjust mixing speed be 68r/min, after Keep agitation 12min, add vaseline wherein again, adjustment mixing speed is 58r/min, now temperature is 41 DEG C, after Keep agitation process 18min, add Borneolum Syntheticum wherein again, add the time controling of Borneolum Syntheticum at 2.7s, and to adjust mixing speed be 110r/min, after Keep agitation 45min, add high sugar more wherein, with 75r/min stir process 13min, the unguentum of the Chinese medicine composition that treatment burn and scald infects can be obtained.
Embodiment 5
Treat the Chinese medicine composition that burn and scald infects, its raw material composition is egg oil 1g, antiinfectious powder 0.5g, high sugared 1g, vaseline 3g, mercurochrome powder 0.08g, Borneolum Syntheticum 0.01g.
Described antiinfectious powder is Radix Notoginseng, Sargassum, Moschus, Radix Glycyrrhizae are after 1:1:1:0.05 mixes according to mass ratio, is ground into 100-140 object powder.
The glucose injection that described height sugar props up for 20ml/, wherein the mass percent of glucose is 50%.
The Chinese medicine composition of this treatment burn and scald, its preparation method be by: get egg oil according to proportioning, the mercurochrome powder of said ratio part is added in egg oil, and adopt the mode stirred while adding, adjustment mixing speed is 41r/min, and control temperature is 31 DEG C, to be added complete after, after Keep agitation 11min, add antiinfectious powder wherein again, and to adjust mixing speed be 69r/min, after Keep agitation 11min, add vaseline wherein again, adjustment mixing speed is 59r/min, now temperature is 41 DEG C, after Keep agitation process 11min, add Borneolum Syntheticum wherein again, add the time controling of Borneolum Syntheticum at 2.1s, and to adjust mixing speed be 95r/min, after Keep agitation 31min, add high sugar more wherein, with 65r/min stir process 8min, the unguentum of the Chinese medicine composition that treatment burn and scald infects can be obtained.
Clinical example:
This medicine carries out clinical experiment by researcher in conjunction with over one hundred routine patient, and make the effective percentage of patient reach 100%, cure rate reaches more than 99.13%, can cure the infection of scalding patient, fire victim, burn patients etc.
When carrying out patient treatment, application pattern traditionally carries out the use of this medicine, namely the method for strict aseptic technique is adopted, be 0.9% normal saline, the benzalkonium bromide of 2% or the Cortex Phellodendri solution cleaning wound surface of 2% with mass fraction, after removing slough, then the unguentum Chinese herbal medicine ointment that the present invention is prepared according to embodiment 3 be coated in wound surface, ointment was changed once according to 3 days courses for the treatment of, after 3-4 week, obvious improvement can be reached, have a significant effect.
There is the situation that typically heals the sick as follows:
Tai literary composition army man Fang Zhao people from village, anteklise town, 28 years old Taijiang County, its biped is that degree of depth III level electric injury penetrance infects, and after applying this medicine, in 3 weeks, substantially heals.
Yang Mei and female people from Kerry, its right hand and upper right, as degree of depth III level burn infection, after applying this medicine, substantially healed in 4 weeks.
Above-mentioned patient is all the treatments carried out in year August in January, 2012 to 2014, and also treatment has other patients during this period, will not enumerate at this.
Chinese herbal medicine ointment of the present invention has the effects such as removing the necrotic tissue and promoting granulation, heat-clearing and toxic substances removing, anti-inflammatory analgetic, and its raw medicinal material is easy to get, cost is low, processing technology is simple, the treatment course for the treatment of that burn and scald is infected can be shortened, and various burn and scald infected patient can be applicable to, at present in Guizhou, Hunan, Guangzhou, zhejiang and other places cured a lot of burn and scald infected patient.
It is important to point out at this; above embodiment and test example are only limitted to be further elaborated technical scheme of the present invention; be not that further restriction is done to technical scheme of the present invention; the essential characteristics of the non-protruding that those skilled in the art make on this basis and the improvement of non-significant progress, all belong to protection category of the present invention.
Claims (7)
1. the Chinese medicine composition for the treatment of burn and scald and infecting, it is characterized in that, its raw material composition (in mass parts) is egg oil 0.5-2 part, antiinfectious powder 0.2-0.7 part, high sugared 0.5-1.5 part, vaseline 2-4 part, mercurochrome powder 0.05-0.1 part, Borneolum Syntheticum 0.005-0.015 part.
2. the Chinese medicine composition for the treatment of burn and scald as claimed in claim 1 infection, it is characterized in that, described raw material composition (in mass parts) is egg oil 0.8-1.5 part, antiinfectious powder 0.3-0.6 part, high sugared 0.8-1.1 part, vaseline 2.5-3.5 part, mercurochrome powder 0.06-0.09 part, Borneolum Syntheticum 0.009-0.013 part.
3. the Chinese medicine composition for the treatment of burn and scald as claimed in claim 1 infection, it is characterized in that, described raw material composition (in mass parts) is egg oil 1 part, antiinfectious powder 0.5 part, high sugar 1 part, 3 parts, vaseline, 0.08 part, mercurochrome powder, Borneolum Syntheticum 0.01 part.
4. the Chinese medicine composition for the treatment of burn and scald as claimed in claim 1 infection, it is characterized in that, described antiinfectious powder is the one in Nuo Meikang antiinfectious powder, sterilization crystallizing sulfanilamide.
5. the Chinese medicine composition for the treatment of burn and scald as claimed in claim 1 infection, is characterized in that, the glucose injection that described height sugar props up for 20ml/, and wherein the mass percent of glucose is 50%.
6. the Chinese medicine composition of the treatment burn and scald as described in any one of claim 1 or 2 or 3, is characterized in that, the preparation of described Chinese medicine composition is unguentum.
7. the Chinese medicine composition of the treatment burn and scald as described in any one of claim 1-5 or the Chinese medicine composition for the treatment of burn and scald according to claim 6, it is characterized in that, its preparation method be by: get egg oil according to proportioning, the mercurochrome powder of said ratio part is added in egg oil, and adopt the mode stirred while adding, adjustment mixing speed is 40-50r/min, and control temperature is 30-40 DEG C, to be added complete after, after Keep agitation 10-15min, add antiinfectious powder wherein again, and to adjust mixing speed be 60-70r/min, after Keep agitation 10-15min, add vaseline wherein again, adjustment mixing speed is 50-60r/min, now temperature is 40-50 DEG C, after Keep agitation process 10-20min, add Borneolum Syntheticum wherein again, add the time controling of Borneolum Syntheticum at 2-3s, and to adjust mixing speed be 90-120r/min, after Keep agitation 30-50min, add high sugar more wherein, with 60-80r/min stir process 5-15min, the unguentum of the Chinese medicine composition that treatment burn and scald infects can be obtained.
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| CN105287976A (en) * | 2015-11-02 | 2016-02-03 | 中国人民解放军第四军医大学 | Anti-infectious conglutinant lotion for wound at burn debridement period and preparation method of anti-infectious conglutinant lotion |
| CN105943636A (en) * | 2016-07-11 | 2016-09-21 | 王朝美 | Bee wax pain relieving cream capable of clearing way heat and diminishing inflammation |
| RU2682454C1 (en) * | 2018-03-29 | 2019-03-20 | федеральное государственное бюджетное научное учреждение "Федеральный центр токсикологической, радиационной и биологической безопасности" (ФГБНУ "ФЦТРБ-ВНИВИ") | Ointment for treatment of thermal burns and method for treatment thereof |
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Cited By (3)
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| CN105287976A (en) * | 2015-11-02 | 2016-02-03 | 中国人民解放军第四军医大学 | Anti-infectious conglutinant lotion for wound at burn debridement period and preparation method of anti-infectious conglutinant lotion |
| CN105943636A (en) * | 2016-07-11 | 2016-09-21 | 王朝美 | Bee wax pain relieving cream capable of clearing way heat and diminishing inflammation |
| RU2682454C1 (en) * | 2018-03-29 | 2019-03-20 | федеральное государственное бюджетное научное учреждение "Федеральный центр токсикологической, радиационной и биологической безопасности" (ФГБНУ "ФЦТРБ-ВНИВИ") | Ointment for treatment of thermal burns and method for treatment thereof |
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| Publication number | Publication date |
|---|---|
| CN104306402B (en) | 2018-05-18 |
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