CN104306169A - Anti-UVA sun-blocking preparation and use method thereof - Google Patents
Anti-UVA sun-blocking preparation and use method thereof Download PDFInfo
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- CN104306169A CN104306169A CN201410493469.3A CN201410493469A CN104306169A CN 104306169 A CN104306169 A CN 104306169A CN 201410493469 A CN201410493469 A CN 201410493469A CN 104306169 A CN104306169 A CN 104306169A
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Abstract
The invention discloses an anti-UVA sun-blocking preparation, wherein each liter of the anti-UVA sun-blocking preparation is composed of the following components: 50-100 mg of gallic acid catechin gallate, 5-10 mg of sodium erythorbate, and the balance water. The use method comprises the steps: the anti-UVA sun-blocking preparation is smeared on skin, and the use amount of per square centimeter of the skin is 0.05-0.2 mL. The anti-UVA sun-blocking preparation has the advantages of good sun-blocking effect and stable performance.
Description
Technical field
The present invention relates to skin care item and cosmetic field, specifically relate to a kind of sun-proof skin care pharmaceutical formulation with uv-resistant A effect.
Background technology
Along with the minimizing of air stratospheric ozone amount and the expansion of Ozone hole, ultraviolet (UV) dosage being irradiated to earth surface in solar irradiation constantly strengthens, and wherein UVA (ultraviolet of 320-400nm) accounts for more than 90%.Be subject to heavy dose of UVA radiation for a long time, the melanin of skin increases, and colour of skin blackening, affects attractive in appearance; Also the diseases such as skin carcinoma may be brought out time serious.Find and have the natural bioactivity substance of uv-resistant A effect, the method for, whitening sun-proof for exploitation, skin protection and treatment dermatosis has positive effect.
Sunscreen actives has multiple.The first kind is UV absorbent, as benzophenone and diphenyl-methane compounds; Equations of The Second Kind is ultraviolet light screener, as the nano powder of titanium dioxide and zinc oxide; The third is native compound, and have absorption, shield and reduce the effect of radiation damage, as Aloe and Fructus Cucumidis sativi extract etc., main component " EGCG " (EGCG) of Folium Camelliae sinensis is also used to the radiation damagies such as uv-resistant B.Because natural sun-screening agents side effect is little, safety, and little to skin irritation, get consumer reception.Have invention with EGCG content be greater than 40% and L-Epicatechin gallate (ECG) be greater than the catechin mixture of 15% for raw material; the preparation of preparation uv-resistant beta radiation damage; prove that in solvent, catechin concentration is when more than 100mg/L; (number of patent application: 200410089236.3), wherein optimal concentration is 200mg/L ~ 250mg/L [1] to have the biological effect from radiation damage of protection.But the natural product problems such as also existence and stability is poor, action effect is unstable.Exploitation good stability, the natural product that action effect is good are the important research directions of this area.
The major effect of UVB radiation to skin causes skin injury (as erythema) even to cause skin carcinoma; UVA is then the melanic synthesis of induced skin and accumulation to the Main Function of skin, causes skin darkening.Although EGCG is once for uv blocking beta radiation damage, the Main Function of sun-screening agent is the skin darkening preventing UVA induction B16 cell from causing.
For Folium Camelliae sinensis EGCG poor stability, easily oxidized and form oxidative condensation thing that is red or brown under light and heat effect, have a strong impact on the problems such as the presentation quality of cosmetics, the present invention adopt separate in Folium Camelliae sinensis, under light and heat impact, more stable Cg epicatechol gallate (GCG) is material, preparation uv-resistant A causes the sun-screening agent of skin darkening.Simultaneously in GCG preparation, add sodium erythorbate, make that stability is better, sun-proof result is stronger.Experimental result shows, the present invention is by after GCG and sodium erythorbate compatibility, and the sun-proof whitening effect of its uv-resistant A is equivalent to the effect of 4-5 times of concentration EGCG, and product has explicit costs advantage; And light at storage degree of oxidation, color stability is obviously better than EGCG.There are some researches show, due to molecular stereo space structure difference, the oxidation resistance of GCG is not as EGCG strong [2].The present invention shows, and after GCG and sodium erythorbate compatibility, the sun-proof whitening effect of its uv-resistant A is obviously better than EGCG.Illustrate that the sun-proof whitening function of GCG uv-resistant A is except antioxidation, also have other factors to play a role.
The list of references above related to is specific as follows:
[1]. Liang Yuerong; Lu Jianliang. with the organism of catechin protection by uv b radiation. national inventing patent application number: CN200410089236.3,2004-12-03.
[2].Muzolf-Panek?M,Gliszczynska-Swiglo?A,Szymusiak?H,Tyrakowska?B.The?influence?of?tereochemistry?on?the?antioxidant?properties?of?catechin?epimers.European?Food?Research?Technology,012,235:11001-1009。
Summary of the invention
The technical problem to be solved in the present invention is to provide sun-screening agent and the using method thereof that a kind of character is stablized than EGCG, uv-resistant A effect is better than EGCG.
In order to solve the problems of the technologies described above, the invention provides a kind of uv-resistant A sun-screening agent, the sun-screening agent of often liter of (L) uv-resistant A is grouped into by the one-tenth of following content:
Cg epicatechol gallate (GCG) 50 ~ 100mg;
Sodium erythorbate 5 ~ 10mg;
Surplus is water (distilled water).
The present invention also provides the using method of above-mentioned uv-resistant A sun-screening agent simultaneously: spread upon on skin by the sun-screening agent of this uv-resistant A, consumption 0.05 ~ 0.2m L of every square centimeter of skin.
In the present invention, GCG, sodium erythorbate all obtain by commercial form.Its preparation method is: GCG50.0 ~ 100.0mg, sodium erythorbate 5.0 ~ 10.0mg are fully stirred in glass or other containers with a small amount of distilled water and make it dissolve, be then diluted to 1.0L (that is, being settled to 1.0L with water).
The using method of said preparation: the uv-resistant A sun-screening agent solution of above-mentioned preparation is directly applied on skin, using dosage every square centimeter 0.05-0.2mL.
Uv-resistant A sun-screening agent of the present invention has that sun-proof result is good, the advantage of stable performance.
Accompanying drawing explanation
Below in conjunction with Fig. 1, the specific embodiment of the present invention is described in further detail.
Fig. 1 is the experiment process figure of uv-resistant A sun-screening agent.
Detailed description of the invention
The sun-screening agent of embodiment 1, a kind of uv-resistant A, its preparation method is: get GCG 50.0mg and sodium erythorbate 5.0mg, puts into beaker and add a small amount of distilled water to make it to dissolve, and is then settled to 1.0L with distilled water.
Contrast A1: get EGCG 200mg put into beaker and add a small amount of distilled water make it dissolve, be then settled to 1.0L with distilled water, sun-screening agent A1 must be contrasted.
Contrast B1: get GCG 50.0mg put into beaker and add a small amount of distilled water make it dissolve, be then settled to 1.0L with distilled water, sun-screening agent B1 must be contrasted.
Contrast C1: make the GCG in embodiment 1 into EGCG, all the other are with embodiment 1.Sun-screening agent C1 must be contrasted.
Contrast D1: get sodium erythorbate 5.0mg, put into beaker and add a small amount of distilled water make it dissolve, be then settled to 1.0L with distilled water.Sun-screening agent D1 must be contrasted.
Contrast E1, make the consumption of the sodium erythorbate in embodiment 1 into 2.0mg by 5.0mg, all the other are with embodiment 1.Sun-screening agent E1 must be contrasted.
Contrast F1, make the consumption of the sodium erythorbate in embodiment 1 into 15mg by 5.0mg, all the other are with embodiment 1.Sun-screening agent F1 must be contrasted.
Blank G1: distilled water.
Test 1, above-described embodiment 1 and contrast A1 ~ contrast G1 detected as follows:
1, be directly applied on the close arm skin in position by the sun-screening agent/distilled water of above-mentioned preparation, using dosage is every square centimeter of 0.05mL.
2, the arm skin after making above-mentioned smearing irradiates 30min at UVA light (10J/cm2).5th day pigment with CBS-1800Skin Analysis Machine mensuration skin, oil content, collagen protein, elasticity and moisture after irradiating; Naked-eye observation skin color.Result is as shown in table 1.
The sun-proof result measured value (%) of table 1. embodiment 1 uv-resistant A sun-screening agent and corresponding contrast
The result display of table 1:
1), embodiment 1 uv-resistant A sun-screening agent pigment content is minimum, but the indexs such as collagen protein, skin elasticity, moisture are the highest; Compared with blank E1 (distilled water), whitening effect clearly; The effect of contrast sun-screening agent D1 (sodium erythorbate 5.0mg/L) is very weak, does not almost have uv-resistant A whitening effect, suitable with blank (distilled water); Illustrate that sodium erythorbate and GCG use simultaneously, have and make effect mutually, preparation uv-resistant A, protection skin and whitening effect can be strengthened.
2), embodiment 1 uv-resistant A sun-screening agent protection skin is slightly better than contrast sun-screening agent A1 from UVA radiation damage and whitening effect; illustrate 50.0mg/L GCG and 5.0mg/L sodium erythorbate used in combination; its effect is better than the effect of EGCG 200.0mg/L, has obvious cost advantage.
3)., the sun-proof result of contrast sun-screening agent C1 is a little less than contrast sun-screening agent A1.
4), learn according to the result of contrast sun-screening agent E1: low concentration arabo-ascorbic acid and GCG Interaction efficiency not obvious; Result according to contrast sun-screening agent F1 is learnt: the arabo-ascorbic acid of excessive concentrations, effect does not promote further.Therefore, select the arabo-ascorbic acid of suitable concentration extremely important.
Embodiment 2, a kind of uv-resistant A sun-screening agent, its preparation method is: get GCG 100.0mg and sodium erythorbate 10.0mg, puts into beaker and adds a small amount of distilled water and fully stir and make it to dissolve completely, be then settled to 1.0L with distilled water.
Contrast A2: get EGCG 500.0mg, puts into beaker and adds a small amount of distilled water and fully stir and make it to dissolve completely, be then settled to 1.0L with distilled water, obtain sun-screening agent A2.
Contrast B2: get GCG 100.0mg put into beaker and add a small amount of distilled water make it dissolve, be then settled to 1.0L with distilled water, sun-screening agent B2 must be contrasted.
Contrast C2: make the GCG in embodiment 2 into EGCG, all the other are with embodiment 2.Sun-screening agent C2 must be contrasted.
Contrast D2: get sodium erythorbate 10.0mg, put into beaker and add a small amount of distilled water make it dissolve, be then settled to 1.0L with distilled water.Sun-screening agent D2 must be contrasted.
Contrast E2: make the consumption of the sodium erythorbate in embodiment 2 into 3mg by 10.0mg; All the other are with embodiment 2.Sun-screening agent E2 must be contrasted.
Contrast F2: make the consumption of the sodium erythorbate in embodiment 2 into 30mg by 10.0mg; All the other are with embodiment 2.Sun-screening agent F2 must be contrasted.
Blank G2: distilled water.
Test 2, above-described embodiment 2 and contrast A2 ~ contrast E2 are detected according to experiment 1, but using dosage makes 0.2mL into by every square centimeter of 0.05mL.
Result as shown in Table 2.
The sun-proof result measured value (%) of table 2. embodiment 2 uv-resistant A sun-screening agent and corresponding contrast
Table 2 result shows:
1), the pigment content of embodiment 2 uv-resistant A sun-screening agent is minimum, but the indexs such as collagen protein, skin elasticity, moisture are the highest; Compared with blank E2 (distilled water), whitening effect clearly; The effect of contrast sun-screening agent D2 (sodium erythorbate 10.0mg/L) is very weak, not obvious with blank E2 (distilled water) difference; Illustrate that sodium erythorbate and GCG use simultaneously, have and make effect mutually, preparation uv-resistant A, protection skin and whitening effect can be strengthened.Every Testing index of embodiment 2 is better than comparative example 1, illustrates that the sun-proof whitening effect of GCG uv-resistant A has concentration-dependent relation; Improve concentration, effect strengthens.
2), embodiment 2 uv-resistant A sun-screening agent uv-resistant A, sun-proof whitening effect are better than contrast sun-screening agent A2, illustrate 100.0mg/L GCG and 10.0mg/L sodium erythorbate used in combination, its effect is better than the effect of EGCG 500.0mg/L, has obvious cost advantage.
3) sun-proof result of sun-screening agent C2, is contrasted a little less than contrast sun-screening agent A2; Illustrate sodium erythorbate and EGCG used in combination have make effect mutually, the sun-proof whitening effect of EGCG uv-resistant A can be strengthened.
4), due to the melanin content increase that uv-resistant A sun-screening agent of the present invention can obviously suppress UVA to induce, the sun-proof whitening effect of UVA is obvious, and skin colour white content and glossiness are all better than contrasting (table 2).
5), learn according to the result of contrast sun-screening agent E2: low concentration arabo-ascorbic acid and GCG Interaction efficiency not obvious; Result according to contrast sun-screening agent F2 is learnt: the arabo-ascorbic acid of excessive concentrations, effect does not promote further.Therefore, select the arabo-ascorbic acid of suitable concentration extremely important.
The result of associative list 1 and table 2, the suitable concentration of arabo-ascorbic acid is 5-10mg/L.
Experiment 3, above-described embodiment 2 and contrast A2 ~ contrast C2, E2, F2 are carried out storage stability as follows and compare:
Get each 50mL of above-mentioned often kind of liquid, measure value of chromatism with TC-PIIG colour difference meter; Each sample is separately got 100mL liquid and is respectively charged into 100mL test tube, and with preservative film sealing, be placed on windowsill, put 15 days in natural lighting and ambient temperatare, again measure value of chromatism, result is as table 3.
Table 3. storage aberration L, a, b value changes
L-value is lightness index, and lightness is higher, and its value is larger; A value is that color is redder on the occasion of interval scale red chromaticity index, and its value is larger; B value is that yellow is darker on the occasion of interval scale yellow chromaticity index, and its value is larger.Before storage experiment, color and luster and the lightness of 6 preparations do not have notable difference.But after the natural lightings of 15 days and room temperature condition storage, sample there occurs obvious differentiation:
1). after storage, the brightness value L of all samples reduces, and a value and b value rise.Forming reason that is red and xanthein after EGCG or GCG oxidation, is the main cause that a value and b value rise; Red and xanthein increases, and absorbing ability strengthens, and also causes brightness value L to reduce.Storage all samples a value and b value rise, and reduce with L, illustrate that EGCG or GCG exists oxidation, but degree of oxidation obvious difference between samples.After storage process, a value and the b value ascensional range of embodiment 2 and contrast sun-screening agent B2 are starkly lower than contrast A2 and C2, illustrate that GCG is more stable than EGCG.
2). a value of embodiment 2 and b value ascensional range are starkly lower than contrast B2, illustrate that sodium erythorbate has the effect strengthening GCG stability.And the stability of embodiment 2 is that in all processing samples, stability is best.
3) although. contrast sun-screening agent A2 uses the EGCG of high concentration to have the sun-proof whitening function (table 2) of good uv-resistant A, but because storage EGCG is oxidized to red and yellow pigment in a large number, a value and b value increase substantially (table 3), poor stability is described, for there is the risk of color and luster instability during sunscreen product.
4), learn according to the result of contrast sun-screening agent E2: low concentration arabo-ascorbic acid is described to GCG stability not as the present invention; Result according to contrast sun-screening agent F2 is learnt: the arabo-ascorbic acid using excessive concentrations is described, can not improves the stability of GCG further.
Finally it should be noted that, what more than enumerate is only some embodiments of the present invention.Obviously, the invention is not restricted to above embodiment, many distortion can also be had.All distortion that those of ordinary skill in the art can directly derive from content disclosed by the invention or associate, all should think protection scope of the present invention.
Claims (2)
1. the sun-screening agent of uv-resistant A, is characterized in that the sun-screening agent of often liter of uv-resistant A is grouped into by the one-tenth of following content: Cg epicatechol gallate 50 ~ 100mg;
Sodium erythorbate 5 ~ 10mg;
Surplus is water.
2. the using method of uv-resistant A sun-screening agent as claimed in claim 1, is characterized in that: spread upon on skin by the sun-screening agent of this uv-resistant A, consumption 0.05 ~ 0.2m L of every square centimeter of skin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410493469.3A CN104306169B (en) | 2014-09-24 | The sun-screening agent of uv-resistant A and using method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410493469.3A CN104306169B (en) | 2014-09-24 | The sun-screening agent of uv-resistant A and using method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104306169A true CN104306169A (en) | 2015-01-28 |
| CN104306169B CN104306169B (en) | 2017-01-04 |
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Citations (4)
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| CN1876064A (en) * | 2006-04-19 | 2006-12-13 | 浙江大学 | A protective agent for resisting UV-B radiation damage |
| CN102370634A (en) * | 2011-11-10 | 2012-03-14 | 云南农业大学 | Application of epigallocatechin gallate |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1631140A (en) * | 2004-12-03 | 2005-06-29 | 浙江大学 | Method for protecting living body in radialization of UV-B using catechuic acid |
| CN1876064A (en) * | 2006-04-19 | 2006-12-13 | 浙江大学 | A protective agent for resisting UV-B radiation damage |
| CN102370634A (en) * | 2011-11-10 | 2012-03-14 | 云南农业大学 | Application of epigallocatechin gallate |
| CN103432114A (en) * | 2013-08-20 | 2013-12-11 | 云南农业大学 | Application of epigallocatechin gallate to preparation of drugs for promoting epidermal repair and regeneration |
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| 王传兴等: "维生素C对光化学诱导皮肤光损伤的光保护作用：OCT定量研究", 《激光生物学报》 * |
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