CN104288650A - Traditional Chinese medicine composition for treating alcoholic myocardiopathy - Google Patents
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- CN104288650A CN104288650A CN201410539727.7A CN201410539727A CN104288650A CN 104288650 A CN104288650 A CN 104288650A CN 201410539727 A CN201410539727 A CN 201410539727A CN 104288650 A CN104288650 A CN 104288650A
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- A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9064—Amomum, e.g. round cardamom
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Abstract
The invention relates to a traditional Chinese medicine composition for treating alcoholic myocardiopathy. The traditional Chinese medicine composition consists of the following traditional Chinese medicine raw materials by weight: 20g of common hogfennel root, 20g of apocynum venetum, 15g of valerian, 30g of pericarpium trichosanthis kirilowii, 30g of Tea Tree Root, 40g of spina date seed, 20g of Amomum kravanh and 10g of allium macrostemon. The traditional Chinese medicine composition disclosed by the invention adopts a pure traditional Chinese medicine preparation, does not have any toxic or side effect, has compatibility of medicines, has an obvious curative effect on the alcoholic myocardiopathy and is high in cure rate.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition for the treatment of alcoholic cardiomyopathy.
Background technology
Alcoholic cardiomyopathy refers to long-term alcohol, makes muscular degeneration of heart, shows as cardiac dilatation, a kind of cardiomyopathy of cardiac insufficiency.This disease has the blood stream rheology of typical dilated cardiomyopathy, symptom, sign and Radiologic imaging, and its definite pathomechanism is also not bery clear at present, and after alleviating alcohol addiction, the state of an illness can a kind of myocardosis of spontaneous remission or recovery from illness.Primary disease is mainly in adult male, and multiparty data shows, and drink Chinese liquor 150ml, continues the generation that can cause alcoholic cardiomyopathy for more than 5 years.
Alcoholic cardiomyopathy is the result of directly poisoning cardiac muscle due to ethanol and metabolite acetaldehyde etc. thereof.The direct toxic action of ethanol to myocardial cell is mainly manifested in following several respects: the integrity 1. damaging myocardial cell membrane, system is by the fat-soluble biological characteristics of ethanol, invasion and attack cell membrane causes liquefaction and changes cell membrane fat composition and molecular configuration, make film surface ion distribute and transmembrane potential out of control, affect cell-tocell transmission and ion exchange; 2. affect organelle function, comprise the organelle such as mitochondrion, sarcoplasmic reticulum functional disorder, so that myocardium energy supply reduces; 3. affect the permeability of myocardial cell ion, thus potassium, phosphate or magnesium are lost from cardiac muscle, and the overload of cytosolic free calcium concentration in cardiomyocyte ion, myocardial contraction can be caused to decline, and is the major reason causing alcoholic cardiomyopathy cardiac insufficiency; 4. the change of intermediate supersession is caused during alcohol metabolism, some enzyme such as aspartate amino transferase (glutamic oxaloacetic transaminase, GOT), malic dehydrogenase, isocitric dehydrogenase, lactic acid dehydrogenase and aldolase in three carboxylic acid circulations are overflowed from myocardial cell, myocardial cell function must be affected, make it can not effectively utilize fatty acid produce power, and triacylglycerol is piled up in cardiac muscle, fat running ATPase activity that is abnormal and sarcostyle changes, and itself has direct repression to cardiac muscle; 5. long-term alcohol changes the structure of Function protein (troponin and tropomyosin), affects myocardial systolic property; 6. long-term heavy drinking still can cause the balanced nutritious imbalance of human body, easily causes vitamin deficiency, and especially vitamin B complex lacks, and also can increase the weight of cardiac insufficiency.In addition, containing the noxious substance such as cobalt, lead in some additive of drinks, long-term drink can cause poisoning or myocardial damage.
The clinical symptoms main manifestations of alcoholic cardiomyopathy is: cardiopalmus, uncomfortable in chest, small number of patients companion's Non-typical angina and fainting, heart failure, arrhythmia, peripheral neuritis and ataxia, can improve more after alleviating alcohol addiction treatment, the state of an illness of again drinking increases the weight of again, goes round and begins again.The key of primary disease treatment is alleviating alcohol addiction, while alleviating alcohol addiction, actively advises smoking cessation, to continuity or reverse disease, improves prognosis.How Chinese traditional treatment not for the medicine typing of alcoholic cardiomyopathy, but is carried out opinion from myocardiac pattern of syndrome and is controlled.Myocardiac tcm syndrome differentiation and typing has: the weak card of the motive, syndrome of deficiency of both qi and yin, gas sun two deficiency syndrome, but alcoholic cardiomyopathy is obviously different with dilated cardiomyopathy inherent mechanism, the former for the domination of pathogen be main good prognosis, the latter is weakened body resistance is main poor prognosis.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition for the treatment of alcoholic cardiomyopathy.
The technical solution adopted for the present invention to solve the technical problems is: a kind of Chinese medicine composition for the treatment of alcoholic cardiomyopathy, be made up of the raw material of Chinese medicine of following weight proportioning: Radix Peucedani 20-30g, Herba Apocyni veneti 10-20g, Rhizoma et radix valerianae 10-20g, fruit-rind of Chinese trichosanthes 10-40g, Radix Camelliae sinensis 20-40g, Semen Ziziphi Spinosae 20-40g, Fructus Amomi Rotundus 10-30g, Bulbus Allii Macrostemonis 10-20g.
Preferably, a kind of Chinese medicine composition for the treatment of alcoholic cardiomyopathy, is made up of the raw material of Chinese medicine of following weight proportioning: Radix Peucedani 20g, Herba Apocyni veneti 20g, Rhizoma et radix valerianae 15g, fruit-rind of Chinese trichosanthes 30g, Radix Camelliae sinensis 30g, Semen Ziziphi Spinosae 40g, Fructus Amomi Rotundus 20g, Bulbus Allii Macrostemonis 10g.
The pharmacologically active of each raw material of Chinese medicine of the present invention is as follows:
Radix Peucedani, bitter in the mouth, pungent, cold nature, returns lung, spleen, Liver Channel, dispelling wind and heat pathogens; Lowering the adverse-rising QI to resolve phlegm.Main affection due to external wind and heat; Lung-heat phlegm stagnancy; Cough with asthma abundant expectoration; Expectorant Huang is sticky; Inverse lack of appetite; Chest and diaphragm is full vexed
Herba Apocyni veneti, sweet, micro-hardship, cool in nature, relieve inflammation or internal heat, blood pressure lowering, heart tonifying, diuresis.Control heart disease, hypertension, neurasthenia, hepatitis abdominal distention, nephritis edema.
Rhizoma et radix valerianae, acrid in the mouth, bitter, warm in nature, GUIXIN, Liver Channel, calm the nerves, and regulates the flow of vital energy, pain relieving.Main irritability; Palpitation and insomnia; Demented; Hysteria; Rheumatic arthralgia; Dysmenorrhea; Amenorrhea; Traumatic injury." Shaanxi Chinese herbal medicine ": " calmness of calming the nerves, wind dispelling spasmolytic, promoting regeneration of the tissue and arresting bleeding, pain relieving.Control hysteria, Keshan disease, heart disease (myocarditis, post partum heart disease, rheumatic heart disease merge heart failure), lumbago and skelalgia, gastrointestinal convulsion, arthritis, traumatic injury, traumatic hemorrhage.″
The fruit-rind of Chinese trichosanthes, sweet in the mouth, micro-hardship, cold in nature, attach to the lung and stomach meridians, removing heat from the lung and dissipating phlegm; Promoting the circulation of QI relieving stuffiness of the chest by dispersing aggregation of pathogens.Main cough due to lung-heat; Breast side of body painful abdominal mass pain, laryngopharynx swelling and pain; Nodules of the breast breast acute mastitis.Pericarpium Trichosanthis and preparation Fructus Trichosanthis injection thereof have coronary artery dilator; increase coronary flow, protection ischemic myocardium, improves hypoxia-bearing capability; reduce serum cholesterol; expansion blood capillary, delays the generation of microcirculation disturbance, obviously can reduce the infarction size of Myocardial Ischemia-reperfusion; inhibitory action is had to the platelet aggregation after Reperfu-sion; and can thrombosis be alleviated and Reperfu-sion is hemorrhage, and still can Protection myocardial inyaretion, there is the effect of the cardiovascular system diseases such as arrhythmia.
Radix Camelliae sinensis, bitter, cool, GUIXIN, the diuresis of kidney channel heart tonifying; Promoting blood flow to regulate menstruation; Heat-clearing and toxic substances removing.Main heart disease; Edema; Hepatitis; Dysmenorrhea; Sore swollen toxin; Aphtha; Soup fire is burnt; Herpes zoster.Arrhythmia (comprise supraventricular premature beat, ventricular premature contraction, the sinus bradycardia etc.) Be very effective caused to coronary heart disease, Myocarditis sequela etc.
Semen Ziziphi Spinosae, sweet, flat, GUIXIN, spleen, liver, gallbladder meridian, mind tranquilizing and the heart calming; Nourishing the liver; Arresting sweating.Main restlessness of asrhenia type and insomnia; Palpitation with fear palpitation with a distress feeling; Body empty spontaneous perspiration, night sweat.
Fructus Amomi Rotundus, pungent, temperature, returns lung, spleen, stomach warp, and removing dampness disappears painful abdominal mass, circulation of qi promoting warming middle-JIAO, appetite-stimulating indigestion-relieving.For turbid damp obstructing in middle-JIAO, anorexia, hygropyrexia from the beginning of, uncomfortable in chest not hungry, cold-damp vomiting, chest and abdomen swelling and pain, food stagnation does not disappear.
Bulbus Allii Macrostemonis, acrid in the mouth, bitter, warm in nature, return lung, the heart, stomach, large intestine channel, the chest stuffiness relieving of regulating the flow of vital energy; Activating YANG and eliminating stagnation.The thorough back of the body of main obstruction of qi in the chest and cardialgia; Breast gastral cavity painful abdominal mass is vexed; Cough with asthma abundant expectoration; Epigastric pain; Heavy after letting out dysentery; Leucorrhea; Furuncle carbuncle." detailed outline ": " control SHAO YIN syndrome to faint and inverse let out dysentery, and thoracic obstruction twinge, the therapeutic method to keep the adverse QI flowing downwards is fallen apart blood, antiabortive.The supporing yang road of " " temperature compensation.″
The present invention has following beneficial effect: the present invention adopts pure Chinese medicinal preparation, has no side effect, and all medicine compatibilities, evident in efficacy to alcoholic cardiomyopathy, cure rate is high.
Detailed description of the invention
Be below specific embodiments of the invention, technical scheme of the present invention is described further, but protection scope of the present invention is not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
Embodiment 1
Treat a Chinese medicine composition for alcoholic cardiomyopathy, be made up of the raw material of Chinese medicine of following weight proportioning: Radix Peucedani 30g, Herba Apocyni veneti 15g, Rhizoma et radix valerianae 10g, fruit-rind of Chinese trichosanthes 40g, Radix Camelliae sinensis 25g, Semen Ziziphi Spinosae 20g, Fructus Amomi Rotundus 30g, Bulbus Allii Macrostemonis 15g.
Embodiment 2
Treat a Chinese medicine composition for alcoholic cardiomyopathy, be made up of the raw material of Chinese medicine of following weight proportioning: Radix Peucedani 25g, Herba Apocyni veneti 10g, Rhizoma et radix valerianae 20g, fruit-rind of Chinese trichosanthes 10g, Radix Camelliae sinensis 20g, Semen Ziziphi Spinosae 30g, Fructus Amomi Rotundus 10g, Bulbus Allii Macrostemonis 15g.
Embodiment 3
Treat a Chinese medicine composition for alcoholic cardiomyopathy, be made up of the raw material of Chinese medicine of following weight proportioning: Radix Peucedani 20g, Herba Apocyni veneti 20g, Rhizoma et radix valerianae 15g, fruit-rind of Chinese trichosanthes 30g, Radix Camelliae sinensis 30g, Semen Ziziphi Spinosae 40g, Fructus Amomi Rotundus 20g, Bulbus Allii Macrostemonis 10g.
Embodiment 4
Treat a Chinese medicine composition for alcoholic cardiomyopathy, be made up of the raw material of Chinese medicine of following weight proportioning: Radix Peucedani 25g, Herba Apocyni veneti 15g, Rhizoma et radix valerianae 20g, fruit-rind of Chinese trichosanthes 20g, Radix Camelliae sinensis 40g, Semen Ziziphi Spinosae 35g, Fructus Amomi Rotundus 25g, Bulbus Allii Macrostemonis 20g.
Clinical data
Physical data: accept for medical treatment altogether alcoholic cardiomyopathy patient 93 example, be male, age 39-61 year, 47 years old mean age.
Clinical symptoms: all patients have the symptoms such as nervous, uncomfortable in chest, weak and dyspnea in various degree when medical, and all repeatedly occur, and with edema of pair of lower extremities.NYHA cardiac functional grading is divided into II ~ IV level, is whole heart failure.
Therapeutic Method: Chinese medicine composition of the present invention is decocted in water for oral dose, every day potion, one day twice, sooner or later sub-service 15 days was a course for the treatment of.
Curative effect judging standard:
Cure: clinical symptom disappearance, sign is normal;
Effective: clinical symptom relief or improvement;
Invalid: clinical symptoms even worsens without improvement.
Therapeutic outcome: cure 73 examples, effective 15 examples, invalid 5 examples, cure rate 78.5%, total effective rate 94.6%, evident in efficacy, have no side effect.
Model case 1
Tight certain, man, 54 years old, continuous more than ten years of drinking white spirit, every day 5-6 two, conscious sensation of oppression over the chest with shortness of breath two months ago, tells white frothy sputum, and after movable, cardiopalmus is obvious, and local hospital is diagnosed as dilated cardiomyopathy, and DeGrain after medication treatment, comes to go to a doctor.Be diagnosed as alcoholic cardiomyopathy on inspection, with traditional Chinese medicine composition for treating of the present invention simultaneously and advise its alleviating alcohol addiction, after the course for the treatment of, chest distress and palpitation symptoms symptom greatly alleviates, and advises the recovery from illness course for the treatment of of its continual cure to leave hospital.
Model case 2
Money so-and-so, man, 49 years old, 8 years history of drinking history, because labour's property is uncomfortable in chest, tachypnea, two lower limbs edema, nocturnal paroxysmal dyspnea be admitted to hospital for 2 years, is diagnosed as alcoholic cardiomyopathy on inspection.Then with the treatment of we's plus-minus, fully recover after two courses for the treatment of.
Claims (2)
1. treat a Chinese medicine composition for alcoholic cardiomyopathy, it is characterized in that, be made up of the raw material of Chinese medicine of following weight proportioning: Radix Peucedani 20-30g, Herba Apocyni veneti 10-20g, Rhizoma et radix valerianae 10-20g, fruit-rind of Chinese trichosanthes 10-40g, Radix Camelliae sinensis 20-40g, Semen Ziziphi Spinosae 20-40g, Fructus Amomi Rotundus 10-30g, Bulbus Allii Macrostemonis 10-20g.
2. the Chinese medicine composition for the treatment of alcoholic cardiomyopathy as claimed in claim 1, is characterized in that, be made up of the raw material of Chinese medicine of following weight proportioning: Radix Peucedani 20g, Herba Apocyni veneti 20g, Rhizoma et radix valerianae 15g, fruit-rind of Chinese trichosanthes 30g, Radix Camelliae sinensis 30g, Semen Ziziphi Spinosae 40g, Fructus Amomi Rotundus 20g, Bulbus Allii Macrostemonis 10g.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105194623A (en) * | 2015-10-27 | 2015-12-30 | 菏泽海诺知识产权服务有限公司 | Traditional Chinese medicine treating alcoholic cardiomyopathy |
CN114994306A (en) * | 2022-05-31 | 2022-09-02 | 哈尔滨医科大学 | Application of protein PKNOX1 in preparation of reagent for diagnosing alcoholic cardiomyopathy and diagnostic kit |
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2014
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CN101129731A (en) * | 2007-08-28 | 2008-02-27 | 邓世明 | Compound for treating obstruction of qi in chest heart ache and formulated product of the same |
EP2324841A1 (en) * | 2008-07-29 | 2011-05-25 | Hebei Yiling Medicine Research Institute Co., Ltd. | Use of a traditional chinese medicinal composition for preparing medicine for promoting bone marrow-derived mesenchymal stem cell survival in vivo and cardiac muscle differentiation |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105194623A (en) * | 2015-10-27 | 2015-12-30 | 菏泽海诺知识产权服务有限公司 | Traditional Chinese medicine treating alcoholic cardiomyopathy |
CN114994306A (en) * | 2022-05-31 | 2022-09-02 | 哈尔滨医科大学 | Application of protein PKNOX1 in preparation of reagent for diagnosing alcoholic cardiomyopathy and diagnostic kit |
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Address after: 276000 Linyi traffic hospital, 36 east section of Jiefang Road, Lanshan District, Shandong, Linyi Applicant after: Zhang Jianli Address before: 276000 Medical District of Jiefang Road 20 people's Hospital, Lanshan District, Shandong, Linyi Applicant before: Zhang Jianli |
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Application publication date: 20150121 |