CN104288465A - Enteric plant essential oil composition for preventing piglet diarrhea and process for preparing the enteric plant essential oil composition for preventing piglet diarrhea - Google Patents

Enteric plant essential oil composition for preventing piglet diarrhea and process for preparing the enteric plant essential oil composition for preventing piglet diarrhea Download PDF

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Publication number
CN104288465A
CN104288465A CN201410575910.2A CN201410575910A CN104288465A CN 104288465 A CN104288465 A CN 104288465A CN 201410575910 A CN201410575910 A CN 201410575910A CN 104288465 A CN104288465 A CN 104288465A
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quintessence oil
piglet diarrhea
enteric
essential oil
oil composition
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CN104288465B (en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses an enteric plant essential oil composition for preventing piglet diarrhea and a process for preparing the enteric plant essential oil composition for preventing piglet diarrhea. The enteric plant essential oil composition is mainly used for preventing piglet diarrhea and especially suitable for substituting antibiotics to prevent diarrhea of piglets at weaning periods. The composition disclosed by the invention mainly comprises carvacrol, thymol and garlic essential oil, which are adsorbed by using macroporous resin and enteric-coated, so that the loss of the volatilization is reduced during storage and transportation, the influence on the palatability and feed intake of piglets is avoided, the ingredients of the composition go to the small intestines of the piglets to directly function, and the curative effect is better; the enteric plant essential oil composition for preventing piglet diarrhea can substitute antibiotics to prevent piglet diarrhea, and has social significance and remarkable economic value.

Description

The enteric plant quintessence oil combination of control piglet diarrhea and preparation technology thereof
Technical field
The present invention " the enteric plant quintessence oil combination of control piglet diarrhea and preparation technology thereof " belongs to feed additive field, is mainly used in preventing and treating piglet diarrhea, is particularly useful for substitute antibiotics to prevent the diarrhoea of weaning period piglet.
Background technology
Piglet diarrhea, particularly weaning period piglet diarrhea are the key common technology difficult problems that pig-breeding industry faces.Piglet, due to early weaning, adds that its developing immune system is unsound, digestive system development is unsound, ablactation stress, changes feedstuff and produce and stress wait factor, be easy to cause diarrhoea, malnutrition, thus have influence on the growth performance of piglet.Statistical data shows, and piglet diarrhea accounts for 40% of piglet mortality rate.Therefore, controlling piglet diarrhea, is the key guaranteeing pig farm culture benefit.Current common way is, adds the antibiotic of high dose and the zinc oxide of high dose in feedstuff.Wherein, the limitation of feedstuff medicated premix that specifies considerably beyond the Ministry of Agriculture of the consumption of colistin and kitasamycin.This mainly because long-term abuse of antibiotics, creates fastbacteria.Antibiotic dosage is low does not have effect at all.Abuse of antibiotics, do great damage to the environment of depending on for existence of the mankind, the residue of veterinary drug in food have impact on the food safety of people.Therefore, with the products substitution antibiosis usually prevention of diarrhea in piglets of safety, become the focus of outer knowledgeable people in the industry.Product of the present invention " the enteric plant quintessence oil combination of control piglet diarrhea and preparation technology thereof ", is just used to substitute antibiotics, to prevent the diarrhoea of piglet.
Summary of the invention
Product of the present invention " the enteric plant quintessence oil combination of control piglet diarrhea and preparation technology thereof ", combines primarily of by carvacrol, thymol and Bulbus Allii quintessence oil.Wherein, the formula proportion of carvacrol, thymol and Bulbus Allii quintessence oil is 1 ~ 3 part of carvacrol, 1 ~ 3 part of thymol, 1 ~ 3 part of Bulbus Allii quintessence oil combines.In the preparation, first carvacrol is mixed homogeneously with Bulbus Allii quintessence oil, then by even for the tween 80 ground and mixed of thymol and 5% ~ 10%, finally by both mix homogeneously, be mixed with quintessence oil mixed liquor.Get the macroporous resin of above-mentioned blend of essential oils weight 1 ~ 3 times amount, and it is mixed homogeneously with above-mentioned blend of essential oils, allow macroporous resin blend of essential oils be adsorbed completely.This has been adsorbed the macroporous resin of blend of essential oils, used ebullated bed coating method, parcel one deck enteric coating, wherein, coatings dry weight is 3% ~ 10% of quintessence oil macroporous resin weight, dry, pack.
Carvacrol (carvacrol, Carvacrol), has the colourless to faint yellow stiff oily liquids of special odor.There is the effect of antioxidation, sterilization.
Thymol (Thymol, 5-methyl-2-isopropyl-phenol), has the flaky crystal of special aroma.There is the effect of sterilization, sterilization.
Bulbus Allii quintessence oil is multicomponent mixture, by allicin (C 6h 10oS 2), allicin (C 6h 10o 2s) and multiple pi-allyl and methyl composition sulfide compound composition, have scavenging free radicals, antibacterial, sterilize, the effect of killing the virus.
After three's compatibility, there is the good effect killing intestinal pathogenic micro.After quintessence oil being adsorbed with macroporous resin, the quintessence oil of liquid is changed into solid, has added the stability of product, be also convenient to mix with feedstuff.
Because above-mentioned three kinds of compositions all have volatility, storing and can cause in transportation the decline of content, thus having influence on the performance of curative effect.In addition, the abnormal smells from the patient of three kinds of compositions also can have influence on the palatability of feedstuff and the feed intake of piglet, and has certain stimulation to the oral mucosa of piglet.Therefore, by the method for enteric coating, itself and air are isolated, make it not dissolve in mouth, only have in intestine of young pigs, just dissolve release, and give full play to curative effect.
Detailed description of the invention
facility example 1
Get 1 part of carvacrol to mix homogeneously with 1 part of Bulbus Allii quintessence oil.Separately get thymol 1 part, and get the tween 80 of its weight 3%, grind altogether, mix homogeneously.Two kinds of mixture are merged, mix homogeneously.Get the macroporous resin of blend of essential oils weight 1 times amount, fully mix.Put in ebullated bed by the macroporous resin adsorbing quintessence oil, air blast makes into fluidisation shape, sprays into acrylic resin enteric-coating material, makes its dry weight be 3% of the macroporous resin weight of having adsorbed quintessence oil.Drying, packaging, namely obtains finished product.
facility example 2
Get 2 parts of carvacrol to mix homogeneously with 1 part of Bulbus Allii quintessence oil.Separately get thymol 1 part, and get the tween 80 of its weight 5%, grind altogether, mix homogeneously.Two kinds of mixture are merged, mix homogeneously.Get the macroporous resin of blend of essential oils weight 2 times amount, fully mix.Put in ebullated bed by the macroporous resin adsorbing quintessence oil, air blast makes into fluidisation shape, sprays into acrylic resin enteric-coating material, makes its dry weight be 5% of the macroporous resin weight of having adsorbed quintessence oil.Drying, packaging, namely obtains finished product.
facility example 3
Get 1 part of carvacrol to mix homogeneously with 2 parts of Bulbus Allii quintessence oils.Separately get thymol 1 part, and get the tween 80 of its weight 8%, grind altogether, mix homogeneously.Two kinds of mixture are merged, mix homogeneously.Get the macroporous resin of blend of essential oils weight 3 times amount, fully mix.Put in ebullated bed by the macroporous resin adsorbing quintessence oil, air blast makes into fluidisation shape, sprays into acrylic resin enteric-coating material, makes its dry weight be 6% of the macroporous resin weight of having adsorbed quintessence oil.Drying, packaging, namely obtains finished product.

Claims (5)

1. prevent and treat the combination of enteric plant quintessence oil and the preparation technology thereof of piglet diarrhea, it is characterized in that: combined by carvacrol, thymol and Bulbus Allii quintessence oil.
2. the enteric plant quintessence oil of control piglet diarrhea according to claim 1 combines and preparation technology, it is characterized in that: the formula proportion of carvacrol, thymol and Bulbus Allii quintessence oil is 1 ~ 3 part of carvacrol, 1 ~ 3 part of thymol, 1 ~ 3 part of Bulbus Allii quintessence oil combine.
3. the enteric plant quintessence oil of control piglet diarrhea according to claim 1 combines and preparation technology, it is characterized in that: first carvacrol is mixed homogeneously with Bulbus Allii quintessence oil, again by even for the tween 80 ground and mixed of thymol and 5% ~ 10%, finally by both mix homogeneously, be mixed with quintessence oil mixed liquor.
4. the enteric plant quintessence oil of control piglet diarrhea according to claim 1 combines and preparation technology, it is characterized in that: the macroporous resin getting the weight 1 ~ 3 of blend of essential oils described in claim 3 times amount, and it is mixed homogeneously with above-mentioned blend of essential oils, allow macroporous resin blend of essential oils be adsorbed completely.
5. the enteric plant quintessence oil of control piglet diarrhea according to claim 1 combines and preparation technology, it is characterized in that: the macroporous resin of blend of essential oils will have been adsorbed described in claim 4, use ebullated bed coating method, parcel one deck enteric coating, wherein, coatings dry weight is 3% ~ 10% of the macroporous resin weight of having adsorbed quintessence oil, dry, pack.
CN201410575910.2A 2014-10-25 2014-10-25 Prevent the combination of enteric plant essential oil and its preparation process of grice diarrhoea Expired - Fee Related CN104288465B (en)

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104800525A (en) * 2015-05-20 2015-07-29 庞兴伟 Medicine for preventing and treating pig diarrhoea
CN105076717A (en) * 2015-07-14 2015-11-25 上海美农生物科技股份有限公司 Formula and processing method of feed additive for improving production performance of animals and guaranteeing health of alimentary canals
CN107125440A (en) * 2016-02-29 2017-09-05 湖南晶天科技实业有限公司 A kind of feed addictive enteric coating tannic acid and preparation method thereof and a kind of feed
CN107410729A (en) * 2017-05-18 2017-12-01 钱信美 A kind of pig feed additive
CN109549001A (en) * 2018-12-26 2019-04-02 无锡正大生物股份有限公司 A kind of suckling piglet nanometer coating plants essential oil and preparation method thereof
CN109645241A (en) * 2019-02-26 2019-04-19 武汉华扬动物药业有限责任公司 A kind of plants essential oil feed addictive and its preparation method and application

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101664113A (en) * 2009-09-08 2010-03-10 北京资源亚太动物药品有限公司 Enteric microcapsule of garlic essential oil and production method thereof
CN102038842A (en) * 2010-12-01 2011-05-04 北京资源亚太动物药品有限公司 Medicament for improving production performance of pigs and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101664113A (en) * 2009-09-08 2010-03-10 北京资源亚太动物药品有限公司 Enteric microcapsule of garlic essential oil and production method thereof
CN102038842A (en) * 2010-12-01 2011-05-04 北京资源亚太动物药品有限公司 Medicament for improving production performance of pigs and preparation method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
刘超良等: "大蒜素对断奶仔猪生长性能和腹泻率的影响", 《养殖与饲料》 *
王笃学等: "《科学使用兽药》", 31 March 2008 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104800525A (en) * 2015-05-20 2015-07-29 庞兴伟 Medicine for preventing and treating pig diarrhoea
CN105076717A (en) * 2015-07-14 2015-11-25 上海美农生物科技股份有限公司 Formula and processing method of feed additive for improving production performance of animals and guaranteeing health of alimentary canals
CN105076717B (en) * 2015-07-14 2019-09-24 上海美农生物科技股份有限公司 For improving breeding performonce fo animals and guaranteeing the feed addictive prescription and processing method of alimentary canal health
CN107125440A (en) * 2016-02-29 2017-09-05 湖南晶天科技实业有限公司 A kind of feed addictive enteric coating tannic acid and preparation method thereof and a kind of feed
CN107410729A (en) * 2017-05-18 2017-12-01 钱信美 A kind of pig feed additive
CN109549001A (en) * 2018-12-26 2019-04-02 无锡正大生物股份有限公司 A kind of suckling piglet nanometer coating plants essential oil and preparation method thereof
CN109645241A (en) * 2019-02-26 2019-04-19 武汉华扬动物药业有限责任公司 A kind of plants essential oil feed addictive and its preparation method and application

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