CN104288354A - Traditional Chinese medicine for treating nasosinusitis - Google Patents

Traditional Chinese medicine for treating nasosinusitis Download PDF

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CN104288354A
CN104288354A CN201410646903.7A CN201410646903A CN104288354A CN 104288354 A CN104288354 A CN 104288354A CN 201410646903 A CN201410646903 A CN 201410646903A CN 104288354 A CN104288354 A CN 104288354A
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chinese medicine
sinusitis
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路云香
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/85—Verbenaceae (Verbena family)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

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Abstract

The invention relates to a traditional Chinese medicine for treating nasosinusitis. The traditional Chinese medicine is prepared from the following raw medicinal materials in parts by weight: 6 parts of yellow chrysanthemum flowers, 6 parts of white puncturevine caltrop fruits, 6 parts of shrub chastetree fruits, 3 parts of uncaria, 6 parts of siberian cocklebur fruits, 3 parts of angelica dahurica, 6 parts of rhizoma ligustici, and 3 parts of licorice roots. Clinical trials prove that the traditional Chinese medicine disclosed by the invention can safely and effectively treat the nasosinusitis.

Description

A kind of Chinese medicine being used for the treatment of sinusitis
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to a kind of Chinese medicine being used for the treatment of sinusitis.
Background technology
The inflammation of the bronchia mucosal that sinusitis and nasal cavity inflammatory diseases are virus, antibacterial, allergen, various physical and chemical factor and some systemic disease cause.The main pathological change of sinusitis is bronchia mucosal hyperemia, swelling, ooze out, hypertrophy, atrophy or necrosis etc.The traditional Chinese medical science is also called nasal sinusitis.
Nasal sinusitis, refers to rhinorrhea with clear discharge, as the nether world oozes, is the cacorhinia of principal character more than amount incessantly.Normal companioned with headache, nasal obstruction, hyposmia, nasal sinuses district pain, then empty endlessly dizzy for a long time.One of Shi Bi section commonly encountered diseases, frequently-occurring disease.Also the title in " sinusitis with purulent discharge ", " brain sand ", " sinusitis with purulent discharge ", " brain deep pool " is had.Many because of the evil poison of affection due to external wind and heat, or wind and cold invasion and attack, heat-transformation for a long time, pathogenic heat are followed through upper steaming, criminal and nose key; Or gallbladder meridian is hot, with through upper criminal, steam the nose key that burns; Or damp-heat in the spleen and stomach, follow stomach through on to disturb etc. and cause.
Just have such record in " Plain Questions lose consciousness opinion " before more than 2,000 years: " nasal sinusitis person, turbid tears stream is more than also ", illustrates that people recognize that nasal sinusitis is with turbid nasal discharge for a long time, amount many more than be the cacorhinia of principal character.Primary disease is common, frequently-occurring disease clinically, and men and women, old and young all can be ill, and common with teenager.Be equivalent to the purulent sinusitis of western medicine.Nasal sinuses is the general name of maxillary sinus, sinus frontalis, sieve hole, sphenoid sinus, and each Dou Jun has opening and communicates with nasal cavity.Both can there is pathological changes separately in them, also multiple or all can occur inflammation, be commonly referred to as sinusitis.Primary disease has anxious nasal sinusitis (acute purulent nasosinusitis) and slow nasal sinusitis (chronic purulent sinusitis) two type, and more common with the latter.
Medical material present Research involved in the present invention is as follows:
Herba Tagetis Patulae [source] this product is the dry capitulum of feverfew chrysanthemum Chrysanthemum morifolium Ramat..Gather when 9 ~ November is spent in full bloom in batches, dry in the shade or dry, or smoked, steam after dry.Medical material is different with processing method by the place of production, is divided into " Flos Chrysanthemi ", " Flos Chrysanthemi ", " Flos Chrysanthemi ", " Flos Chrysanthemi ".This product with Flos Chrysanthemi be advisable [nature and flavor] sweet, bitter, be slightly cold.[return through] returns lung, Liver Channel.[function cures mainly] falls apart wind heat clearing away, suppressing the hyperactive liver improving eyesight.For anemopyretic cold, have a headache dizzy, conjunctival congestion and swelling pain, eyes is dim-sighted.[usage and dosage] 5 ~ 9g.
Fructus Atriplicis Sibiricae [source] this product is the dry mature fruit of zygophyllaceae plant Fructus Tribuli Tribulus terrestris L..Tap plant during fruit maturation in autumn, dry, lay fruit, removing impurity.[nature and flavor] are pungent, bitter, tepor; Slightly poisonous.[return through] returns Liver Channel.[function cures mainly] suppressing the hyperactive liver resolving depression, promoting blood circulation by removing wind, improving eyesight, antipruritic.Dizzy for having a headache, distending pain in the chest and hypochondrium, breast closes acute mastitis, cataract, rubella pruritus.[usage and dosage] 6 ~ 9g.
Fructus Viticis [source] this product is the dry mature fruit of Verbenaceae Vitex rotundifolia Vitex trifolia L. var. simplicifolia Cham. or wild pepper Vitex trifolia L..Gather during fruit maturation in autumn, removing impurity, dries.[nature and flavor] are pungent, bitter, are slightly cold.[return through] returns bladder, liver, stomach warp.[function cures mainly] dispelling wind and heat pathogens, the clear sharp head.For anemopyretic cold headache, gingivitis, the many tear of conjunctival congestion, poor vision, has a dizzy spell.[usage and dosage] 5 ~ 9g.
Ramulus Uncariae Cum Uncis [source] this product is the dry stem and branch with belt hook of Maguireothamnus speciosus Ramulus Uncariae Cum Uncis Uncaria rhynch0phylla (Miq.) Jacks., Ramulus Uncariae macrophyllae Uncaria macrophylla Wall., Ramulus Uncariae Cum Uncis Uncaria hirsuta Havil., Uncaria sinensis (Oliv.) Havil. Uncaria sinensis (Oliv.) Havil. or stockless fruit Ramulus Uncariae Cum Uncis Uncaria sessilifructus Roxb..Autumn, season in winter two gather, and defoliation, cutting, dries.[nature and flavor] are sweet, cool.[return through] returns liver, pericardium channel.[function cures mainly] heat clearing away suppressing the hyperactive liver, dispelling wind and relieving convulsion.Dizzy for having a headache, dysphoric cold, infantile convulsion is twitched, pre-eclampsia; Hypertension.[usage and dosage] 3 ~ 12g.
 
Fructus Xanthii [source] this product is the fruit of the drying and ripening band involucre of feverfew Herba Xanthii Xanthium sibiricum Patr..Gather during fruit maturation in autumn, dry, except impurity such as destemming, leaves.Herb also can be used as medicine.[nature and flavor] are pungent, bitter, temperature; Poisonous.[return through] returns lung meridian.[function cures mainly] Fructus Xanthii: loose wind dehumidifying, clearing the nasal passage.For headche due to wind-cold, nasal sinusitis watery nasal discharge, rubella pruritus, arthralgia chiefly caused by damp pathogen contracture.[usage and dosage] Fructus Xanthii 3 ~ 9g.
The Radix Angelicae Dahuricae [source] this product is umbellate form section plant Radix Angelicae Dahuricae Angelica dahurica (Fisch.ex Hoffm.) Benth. et Hook.f. or Radix angelicae dahuricae Angelica dahurica(Fisch.ex Hoffm.) Benth.et Hook.f. var.formosana(Boiss.) dry root of Shan et Yuan.Excavate when between summer, autumn, leaf is yellow, removing fibrous root and silt, dry or cold drying.[nature and flavor] are pungent, temperature.[return through] returns stomach, large intestine, lung meridian.[function cures mainly] loose wind dehumidifying, understand things pain-stopping, detumescence and apocenosis.For headache due to common cold, supraorbital bone pain, nasal obstruction, nasal sinusitis, toothache, leucorrhea, skin infection swells and ache.[usage and dosage] 3 ~ 9g.
Rhizoma Ligustici [source] this product is dry rhizome and the root of Umbelliferae Ligustrum plant Rhizoma Ligustici Ligusticum sinense Oliv. or Rhizoma Ligustici Ligusticum jeholense Nakai et Kitag..Autumn stem and leaf withered or the secondary spring emerges time excavate, removing silt, dries or dries.[nature and flavor] are pungent, temperature.[return through] returns urinary bladder channel.[function cures mainly] dispels the wind, cold expelling, dehumidifying, pain relieving.For anemofrigid cold, top, mountain peak pain, rheumatism podomere arthralgia pain.[usage and dosage] 3 ~ 9g.
Radix Glycyrrhizae [source] this product is the dry root of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..Spring, Qiu Erji excavate, and removing fibrous root, dries.[nature and flavor] are sweet, flat.[return through] GUIXIN, lung, spleen, stomach warp.[function cures mainly] invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.[usage and dosage] 1.5 ~ 9g.
Summary of the invention
The present invention aims to provide a kind of Chinese medicine being used for the treatment of sinusitis, by selecting suitable medical material and proportioning thereof, reaches the object of safe and effective healing sinusitis.
In order to achieve the above object, the present invention is by the following technical solutions:
Be used for the treatment of a Chinese medicine for sinusitis, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Herba Tagetis Patulae 6 parts, Fructus Atriplicis Sibiricae 6 parts, Fructus Viticis 6 parts, Ramulus Uncariae Cum Uncis 3 parts, Fructus Xanthii 6 parts, the Radix Angelicae Dahuricae 3 parts, Rhizoma Ligustici 6 parts, 3 parts, Radix Glycyrrhizae.
Inventor thinks that sinusitis is lost in taking good care of by ferritic innate deficiency or the day after tomorrow, cause liver and gall heat very to be held concurrently and stagnantly not understand by ailment said due to cold or exposure is solid, controls to let out clearly liver and gall, dispelling wind evil with three sun and control therefore assembly we.
Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:
1, physical data
Inventor collects outpatient service and sinusitis in patients 96 example of being in hospital altogether between in August, 2011 ~ in May, 2013, be divided into treatment group 48 example and matched group 48 example at random, treatment group man 24 example, female 24 example, 20 ~ 45 years old age, 37.3 years old mean age, the course of disease 1 ~ 3 year; Matched group man 26 example, female 22 example, 22 ~ 45 years old age, 37.9 years old mean age, the course of disease 1 ~ 3 year.2 groups of sexes, age and course of disease comparing difference not statistically significants, have comparability.
Diagnostic criteria
Effective: headache, dizzy, the facial cardinal symptoms such as sample, nasal obstruction, purulent secretion that swell disappear, and in order, intranasal is without obvious pus sample deposit for nasal endoscopes.Effective: headache, dizzy, the facial cardinal symptoms such as sample, nasal obstruction, purulent secretion that swell alleviate, and intranasal deposit reduces, but CT examination imaging is comparatively fuzzy.Invalid: cardinal symptom does not have remarkable improvement or increases the weight of.
2 Therapeutic Method
The decoct that the oral the present invention for the treatment of group obtains according to specific embodiment 1, every day 3 times.16 weeks courses for the treatment of.
Matched group oral azithromycin (operative norm " Chinese Pharmacopoeia " 2010 Nian Banerbu Qilu Pharmaceutical Co., Ltd.), takes according to its description.16 weeks courses for the treatment of.
3, therapeutic outcome
Therapeutic outcome is in table 1.
Table 1 liang group comparitive study
Group n Effective Effectively Invalid Total effective rate (%) Serious adverse reaction example
Treatment group 48 15 27 6 87.50% 0
Matched group 48 12 20 16 66.67% 0
Visible, the medicine that the present invention obtains can safe and effective treatment sinusitis, has promotional value.
Detailed description of the invention
In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Specific embodiment 1
Take: Herba Tagetis Patulae 6 grams, Fructus Atriplicis Sibiricae 6 grams, Fructus Viticis 6 grams, Ramulus Uncariae Cum Uncis 3 grams, Fructus Xanthii 6 grams, the Radix Angelicae Dahuricae 3 grams, Rhizoma Ligustici 6 grams, 3 grams, Radix Glycyrrhizae; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 grams, must meet the decoct of adult normal's one day consumption.
Be used for the treatment of sinusitis.Oral, every bu morning, noon and afternoon take for three times.
Specific embodiment 2
Take: Herba Tagetis Patulae 6 grams, Fructus Atriplicis Sibiricae 6 grams, Fructus Viticis 6 grams, Ramulus Uncariae Cum Uncis 3 grams, Fructus Xanthii 6 grams, the Radix Angelicae Dahuricae 3 grams, Rhizoma Ligustici 6 grams, 3 grams, Radix Glycyrrhizae; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, must meet the powder of adult normal's one day consumption.
Be used for the treatment of sinusitis.Oral, daily once.
Specific embodiment 3
Take: Herba Tagetis Patulae 6 grams, Fructus Atriplicis Sibiricae 6 grams, Fructus Viticis 6 grams, Ramulus Uncariae Cum Uncis 3 grams, Fructus Xanthii 6 grams, the Radix Angelicae Dahuricae 3 grams, Rhizoma Ligustici 6 grams, 3 grams, Radix Glycyrrhizae; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, must meet the capsule of adult normal's one day consumption.
Be used for the treatment of sinusitis.Oral, every bu is taken for twice sooner or later.

Claims (1)

1. be used for the treatment of a Chinese medicine for sinusitis, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Herba Tagetis Patulae 6 parts, Fructus Atriplicis Sibiricae 6 parts, Fructus Viticis 6 parts, Ramulus Uncariae Cum Uncis 3 parts, Fructus Xanthii 6 parts, the Radix Angelicae Dahuricae 3 parts, Rhizoma Ligustici 6 parts, 3 parts, Radix Glycyrrhizae.
CN201410646903.7A 2014-11-16 2014-11-16 Traditional Chinese medicine for treating nasosinusitis Pending CN104288354A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1840032A (en) * 2006-01-28 2006-10-04 安徽科创中药天然药物研究所有限责任公司 Granule for treating infant's rhinitis, its preparation method and quality control method
CN103908536A (en) * 2014-03-31 2014-07-09 青岛百瑞吉生物工程有限公司 Traditional Chinese medicinal preparation for treating nasosinusitis, preparation method and application thereof
CN104000953A (en) * 2014-04-25 2014-08-27 万强胜 Traditional Chinese medicinal composition for treating rhinitis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1840032A (en) * 2006-01-28 2006-10-04 安徽科创中药天然药物研究所有限责任公司 Granule for treating infant's rhinitis, its preparation method and quality control method
CN103908536A (en) * 2014-03-31 2014-07-09 青岛百瑞吉生物工程有限公司 Traditional Chinese medicinal preparation for treating nasosinusitis, preparation method and application thereof
CN104000953A (en) * 2014-04-25 2014-08-27 万强胜 Traditional Chinese medicinal composition for treating rhinitis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
祝安治等: "谷精合剂治疗鼻渊44例", 《陕西中医》 *

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Application publication date: 20150121