CN104287865A - Fixing and observing device for living imaging of animal spinal cords - Google Patents
Fixing and observing device for living imaging of animal spinal cords Download PDFInfo
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- CN104287865A CN104287865A CN201410571850.7A CN201410571850A CN104287865A CN 104287865 A CN104287865 A CN 104287865A CN 201410571850 A CN201410571850 A CN 201410571850A CN 104287865 A CN104287865 A CN 104287865A
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- adjusting device
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/40—Detecting, measuring or recording for evaluating the nervous system
- A61B5/4058—Detecting, measuring or recording for evaluating the nervous system for evaluating the central nervous system
- A61B5/407—Evaluating the spinal cord
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
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Abstract
A fixing and observing device for living imaging of animal spinal cords comprises a bottom plate (1), a left movement adjusting device (2), a right movement adjusting device (3) and an embedded observation window (4). The left movement adjusting device (2) and the right movement adjusting device (3) are fixedly connected to the bottom plate (1) through screws. The embedded observation window (4) is in insertion connection with rectangular protrusions of horizontal positioning sliders on the left movement adjusting device (2) and the right movement adjusting device (3) through rectangular holes in V-shaped frames to be positioned. By the fixing and observing device, operations for installing the embedded observation window can be facilitated to improve stability of the spinal cords, and dynamic observation of post-operation two-photon spinal-cord imaging can be also facilitated. The horizontal positioning sliders on the left movement adjusting device and the right movement adjusting device can guarantee horizontal stable internal fixation states for implant operations and can further provide stable external fixation support during post-operation observation.
Description
Technical field:
The present invention relates to a kind of animal spinal cord living imaging Orientation observation device, it is used in the experimentation in neurobiology field, the installation operation of implanted observation window can be carried out to animal, and the change that live body dynamically observes spinal nervous tissue and blood vessel thereof can be carried out for a long time, to the particularly physiology of spinal cord injury and the pathological change of research nervus centralis, and after spinal cord injury, neural renewable reservoir has very large value.
Background technology:
In the experimentation in neurobiology field, traditional animal spinal cord living imaging means are the vertebral plate of an excision animal sections thus exposing spinal cord, after using whole body suspension method or local Clamping stabilizing spine, fluorescence microscope or Two Photon Fluorescence is used to carry out the dynamic imaging of live body to the animal spinal cord exposed.Imaging terminates rear layer-by-layer suture muscle and skin, cuts skin and muscle more next time, expose original segments of spinal cord with this repeatedly when observing.But this process can not last long, anesthesia and repeat surgery not only can bring the harm of whole body function to animal for a long time, more can improve animal infected risk, increase inflammatory reaction, cause tissue injury, initiation animal is more painful, is unfavorable for further observing and experimentation.And the operation of not seeking unity of standard at present is fixing and clinical follow external fixer, causes operation technique complicated, the difficulty that postoperative imaging is fixing.
Summary of the invention:
1, object: the object of this invention is to provide a kind of animal spinal cord living imaging Orientation observation device.It can either be conducive to the installation operation of implanted observation window, makes the stability of spinal column better, can be conducive to again the dynamic observation of postoperative two-photon spinal cord imaging.The internal fixtion state that the horizontal location slide block of living imaging external fixer provide horizontal direction stable can not only to the operation of implantation device, gives stable extenal fixation and supports when more can observe after surgery.
2, technical scheme: technical scheme of the present invention is: a kind of animal spinal cord living imaging Orientation observation device, it is made up of base plate (1), the mobile adjusting device in left side (2), the mobile adjusting device in right side (3) and implanted observation window (4); Position annexation between them is: the mobile adjusting device in left side (2), the mobile adjusting device in right side (3) are fixed on base plate (1) by screw, and implanted observation window (4) plugs together location by the rectangular preiection of the horizontal location slide block on the rectangular opening on its V-type frame and left side mobile adjusting device (2), the mobile adjusting device in right side (3).
Described base plate (1) is one piece of rectangle plate, its be each side provided with two install screwed holes for the mobile adjusting device in left side (2), the mobile adjusting device in right side (3) fixing.
The mobile adjusting device in described left side (2) is made up of dovetail groove base (2-1), horizontal location slide block (2-2) and dog screw (2-3); Position annexation between them is: this dovetail groove base (2-1) is in swallow-tail form in the horizontal direction, can make horizontal location slide block (2-2) bilateral reciprocation being within it similarly swallow-tail form; When sliding into target location, screw dog screw (2-3), dog screw withstands dovetail groove base (2-1), reaches the object preventing dovetail groove base (2-1) and horizontal location slide block (2-2) relative sliding.The rectangular shape of this dovetail groove base (2-1) profile, horizontal direction is provided with swallow tail shaped slot, and vertical direction is rectangular block.This horizontal location slide block (2-2) is that rectangular slab materials and parts process, and the screw that it is arranged is used for and the connection of dog screw (2-3) and location, and end is processed into rectangular preiection and is convenient to plug together location with the rectangular opening on wishbone; Afterbody is processed into dovetail form and is convenient to slide in dovetail groove base (2-1).This dog screw (2-3) is commercial connector.
The mobile adjusting device in described right side (3) is identical with left side mobile adjusting device (2) structure, and specular is installed;
Described implanted observation window (4) is made up of left side wishbone (4-1), right side wishbone (4-2), strip pad (4-3), rectangle coverslip (4-4) and mounting screw (4-5); Position annexation between them is: left side wishbone (4-1) and right side wishbone (4-2) are respectively provided with two screwed holes, after position is fixing, strip pad (4-3) is vertically placed on left and right sides wishbone screwed hole, by mounting screw (4-5), strip pad (4-3) and left and right sides wishbone is fixed.In the middle of two strip pads (4-3), rectangle coverslip (4-4) can be inserted.Distance between left side wishbone (4-1) and right side wishbone (4-2) can be regulated by the adjustment hole of strip pad (4-3).
Operation principle of the present invention and flow process brief introduction as follows:
Operation principle of the present invention is: by living imaging external fixer and implanted observation window, realize the object of installing animal spinal cord implanted observation window, and then postoperative use Two Photon Fluorescence carries out living imaging to spinal cord, thus complete the operation of vivo observation spinal cord neural cell dynamic change.
Workflow of the present invention is: for further illustrating technical scheme of the present invention, is now briefly described as follows by the operative process that the present invention carries out:
(1) operation installed by implanted observation window: by Animal Anesthesia, back uses iodophor disinfection after shaving hair, is placed on base plate, and skin is cut in projection place of edge back part of animal central authorities breast 13-waist 2, cleaning breast 13-waist 2 vertebral plate Surrounding muscles and soft tissue, appear breast 13-waist 2 vertebral plate.
(2) both sides horizontal location slide block is stretched into wishbone slotted eye, namely both sides wishbone load level positioning sliding block, horizontal slip horizontal location slide block, makes both sides wishbone clamping breast 13-waist 2 vertebral body.
(3) use micro-shears by waist 1 vertebrae plate resection, fully expose waist 1 segments of spinal cord.
(4) strip pad is positioned over above both sides wishbone and spinal cord, tightens four screws.
(5) at the biological silicone rubber of spinal cord surface coverage one deck, by rectangle coverslip covering resin.Use rapid-curing cutback seccotine and dental base acrylic resin powder fix and close implanted observation window, after seccotine and dental base acrylic resin powder solidify, both sides horizontal location slide block is shifted out both sides V-type frame slotted eye, skin suture has been performed the operation.
(6) Two Photon Fluorescence is observed fixing: by Animal Anesthesia, is positioned over living imaging external fixer central authorities.By both sides horizontal location slide block horizontal slip, stretch into wishbone both sides slotted eye, fixing implanted observation window and animal spinal column.
(7) Two Photon Fluorescence is used to carry out live body neuroimaging to animal spinal cord.
(8) observed, both sides horizontal location slide block has been shifted out both sides V-type frame slotted eye.
The present invention has the following advantages:
1, implanted observation window is conducive to using Two Photon Fluorescence to carry out long-term live body to animal spinal cord and dynamically observe, and avoids the problem that repeat surgery brings.
2, external fixer is not only conducive to the carrying out that operation installed by implanted observation window, is more conducive to the fixing of postoperative animal spinal cord observation.
3, this system is applied widely, can be used for the large-scale experiment animals such as rat, rabbit, Canis familiaris L., monkey after change size.
Accompanying drawing explanation
Fig. 1 is the structure chart of this animal spinal cord living imaging Orientation observation device
Fig. 2 a is the structure chart of implanted observation window
Fig. 2 b is wishbone schematic diagram
Fig. 2 c is strip pad schematic diagram
Fig. 2 d is rectangle coverslip schematic diagram
Fig. 3 a is the structure chart of mobile adjusting device
Fig. 3 b is horizontal location slide block schematic diagram
Fig. 3 c is dovetail groove base schematic diagram
Fig. 4 is base plate schematic diagram
In figure, sequence number is described as follows:
1, base plate; 2, the mobile adjusting device in left side; 3, the mobile adjusting device in right side; 4, implanted observation window;
2-1, dovetail groove base; 2-2, horizontal location slide block; 2-3, dog screw;
4-1, left side wishbone; 4-2, right side wishbone; 4-3, strip pad; 4-4, rectangle coverslip; 4-5, mounting screw.
Detailed description of the invention
See Fig. 1-Fig. 4, technical scheme of the present invention is: a kind of animal spinal cord living imaging Orientation observation device, and it is made up of base plate (1), the mobile adjusting device in left side (2), the mobile adjusting device in right side (3), implanted observation window (4); Position annexation between them is: the mobile adjusting device in left side (2), the mobile adjusting device in right side (3) are fixed on base plate (1) by screw, and implanted observation window (4) plugs together location by the rectangular preiection on rectangular opening on it and left side mobile adjusting device (2), the mobile adjusting device in right side (3).
Described installation (1) is one piece of rectangle plate, its each side arrange two install screwed holes for the mobile adjusting device in left side (2), the mobile adjusting device in right side (3) fixing.
The mobile adjusting device in described left side (2) is made up of dovetail groove base (2-1), horizontal location slide block (2-2) and dog screw (2-3); Position annexation between them is: this dovetail groove base (2-1) is in swallow-tail form in the horizontal direction, can make horizontal location slide block (2-2) bilateral reciprocation being within it similarly swallow-tail form; When sliding into target location, screw dog screw (2-3), dog screw withstands dovetail groove base (2-1), reaches the object preventing dovetail groove base (2-1) and horizontal location slide block (2-2) relative sliding.The rectangular shape of this dovetail groove base (2-1) profile, horizontal direction is provided with swallow tail shaped slot, and vertical direction is rectangular block.This horizontal location slide block (2-2) is that rectangular slab materials and parts process, and the screw that it is arranged is used for and the connection of dog screw (2-3) and location, and end is processed into rectangular preiection and is convenient to plug together location with the rectangular opening on wishbone; Afterbody is processed into dovetail form and is convenient to slide in dovetail groove base (2-1).This dog screw (2-3) is commercial connector.
The mobile adjusting device in described right side (3) is identical with left side mobile adjusting device (2) structure, and mirror image is installed;
Described implanted experiment porch (4) is made up of left side wishbone (4-1), right side wishbone (4-2), strip pad (4-3), rectangle coverslip (4-4) and mounting screw (4-5); Position annexation between them is: left side wishbone (4-1) and right side wishbone (4-2) respectively have two screwed holes, after position is fixing, strip pad (4-3) is vertically placed on left and right sides wishbone screwed hole, by mounting screw (4-5), strip pad (4-3) and left and right sides wishbone is fixed.In the middle of two strip pads (4-3), rectangle coverslip (4-4) can be inserted.Distance between left side wishbone (4-1) and right side wishbone (4-2) can be regulated by the adjustment hole of strip pad (4-3).
Be schematic with reference to the accompanying drawing description of this invention above, do not have restricted, those skilled in the art should be understood that, in reality is implemented, in the present invention, the shape of each component and layout type some all may occur change; And under enlightenment of the present invention, other staff also can make the design similar with the present invention or the present invention is modified and certain component be equal to replacement.Special needs to be pointed out is, only otherwise depart from design aim of the present invention, all apparent changes and have equivalent similar Design of replacing, are all included within protection scope of the present invention.
Claims (1)
1. an animal spinal cord living imaging Orientation observation device, is characterized in that: it is made up of base plate (1), the mobile adjusting device in left side (2), the mobile adjusting device in right side (3) and implanted observation window (4); The mobile adjusting device in left side (2), the mobile adjusting device in right side (3) are fixed on base plate (1) by screw, and implanted observation window (4) plugs together location by the rectangular preiection of the horizontal location slide block on the rectangular opening on its V-type frame and left side mobile adjusting device (2), the mobile adjusting device in right side (3);
Described base plate (1) is one piece of rectangle plate, its be each side provided with two install screwed holes for the mobile adjusting device in left side (2), the mobile adjusting device in right side (3) fixing;
The mobile adjusting device in described left side (2) is made up of dovetail groove base (2-1), horizontal location slide block (2-2) and dog screw (2-3); This dovetail groove base (2-1) is in swallow-tail form in the horizontal direction, makes horizontal location slide block (2-2) bilateral reciprocation being within it similarly swallow-tail form; When sliding into target location, screw dog screw (2-3), dog screw withstands dovetail groove base (2-1), reaches the object preventing dovetail groove base (2-1) and horizontal location slide block (2-2) relative sliding; The rectangular shape of this dovetail groove base (2-1) profile, horizontal direction is provided with swallow tail shaped slot, and vertical direction is rectangular block; This horizontal location slide block (2-2) is that rectangular slab materials and parts process, the screw that it is arranged is used for and the connection of dog screw (2-3) and location, end is processed into rectangular preiection and is convenient to plug together location with the rectangular opening on wishbone, and afterbody is processed into dovetail form and is convenient to slide in dovetail groove base (2-1);
The mobile adjusting device in described right side (3) is identical with left side mobile adjusting device (2) structure, and specular is installed;
Described implanted observation window (4) is made up of left side wishbone (4-1), right side wishbone (4-2), strip pad (4-3), rectangle coverslip (4-4) and mounting screw (4-5); Left side wishbone (4-1) and right side wishbone (4-2) are respectively provided with two screwed holes, after position is fixing, strip pad (4-3) is vertically placed on left and right sides wishbone screwed hole, by mounting screw (4-5), strip pad (4-3) and left and right sides wishbone is fixed; In the middle of two strip pads (4-3), insert rectangle coverslip (4-4), the distance between left side wishbone (4-1) and right side wishbone (4-2) is then regulated by the adjustment hole of strip pad (4-3).
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410571850.7A CN104287865B (en) | 2014-10-23 | 2014-10-23 | A kind of animal spinal cord living imaging Orientation observation device |
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| CN201410571850.7A CN104287865B (en) | 2014-10-23 | 2014-10-23 | A kind of animal spinal cord living imaging Orientation observation device |
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| CN104287865A true CN104287865A (en) | 2015-01-21 |
| CN104287865B CN104287865B (en) | 2016-11-09 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104771145A (en) * | 2015-04-14 | 2015-07-15 | 中国人民解放军总医院 | Animal dorsal root ganglion-spinal cord fixed imaging and compression injury combining device |
| CN108784881A (en) * | 2018-03-28 | 2018-11-13 | 中国人民解放军总医院 | A kind of mouse kidney live body micro-imaging and tracer corollary system |
| CN111419181A (en) * | 2020-03-31 | 2020-07-17 | 浙江大学 | Device for long-time living body imaging of small animal and using method thereof |
| CN113413231A (en) * | 2021-06-21 | 2021-09-21 | 深圳市人民医院 | Fixed observation device for animal spinal nerve living body imaging and use method thereof |
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| CN204092265U (en) * | 2014-10-23 | 2015-01-14 | 中国人民解放军总医院 | A kind of animal spinal cord living imaging Orientation observation device |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104771145A (en) * | 2015-04-14 | 2015-07-15 | 中国人民解放军总医院 | Animal dorsal root ganglion-spinal cord fixed imaging and compression injury combining device |
| CN104771145B (en) * | 2015-04-14 | 2017-04-12 | 中国人民解放军总医院 | Animal dorsal root ganglion-spinal cord fixed imaging and compression injury combining device |
| CN108784881A (en) * | 2018-03-28 | 2018-11-13 | 中国人民解放军总医院 | A kind of mouse kidney live body micro-imaging and tracer corollary system |
| CN108784881B (en) * | 2018-03-28 | 2023-05-16 | 中国人民解放军总医院 | Mouse kidney living body microscopic imaging and tracing matching system |
| CN111419181A (en) * | 2020-03-31 | 2020-07-17 | 浙江大学 | Device for long-time living body imaging of small animal and using method thereof |
| CN111419181B (en) * | 2020-03-31 | 2023-07-25 | 浙江大学 | Device for long-time living body imaging of small animals and application method thereof |
| CN113413231A (en) * | 2021-06-21 | 2021-09-21 | 深圳市人民医院 | Fixed observation device for animal spinal nerve living body imaging and use method thereof |
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