CN104287804A - Biological cavity blocking device - Google Patents
Biological cavity blocking device Download PDFInfo
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- CN104287804A CN104287804A CN201410582090.XA CN201410582090A CN104287804A CN 104287804 A CN104287804 A CN 104287804A CN 201410582090 A CN201410582090 A CN 201410582090A CN 104287804 A CN104287804 A CN 104287804A
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- Prior art keywords
- plugging
- biological cavities
- holder part
- biological
- cavities
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12122—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder within the heart
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12027—Type of occlusion
- A61B17/12031—Type of occlusion complete occlusion
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12168—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
- A61B17/12172—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure having a pre-set deployed three-dimensional shape
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12168—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
- A61B17/12177—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure comprising additional materials, e.g. thrombogenic, having filaments, having fibers or being coated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B2017/1205—Introduction devices
Abstract
The invention relates to an implantable biological cavity blocking device which comprises a blocking structure and at least two support parts. Each support part is in a closed hollow multilateral stereo shape and is provided with fixed protrusions. The support parts are used for bearing the blocking structure and can help to fix the blocking structure in a cavity, and the blocking structure is prevented from falling down due to some reasons such as atrial fibrillation. The blocking device is arranged in a cavity like the left aurcle, is good in self-centering performance, stable in fixing, good in left aurcle sealing effect, and capable of being repeatedly located.
Description
Technical field
The present invention relates to a kind of medical apparatus and instruments, in particular, relate to a kind of method got involved by microcatheter technology utilization and be sent to left atrium, shutoff left auricle, cause the disease of apoplexy for prevention causes Left atrial appendage to be deviate from due to atrial fibrillation.
Background technology
Interventional therapy is the emerging therapeutic method between surgery, medical treatment, comprises intravascular intervention and Non-vascularized iliac bone treatment.Through the development of more than 30 years, three large pillar subjects are called now together with surgery, internal medicine.Simply say, interventional therapy is exactly when not operating on exposure focus, blood vessel, skin are done the minim channel of diameter several millimeters, or through the original pipeline of human body, to the method for the minimum treatment of the focus local wound for the treatment of under the guiding of image documentation equipment (angiography machine, fluoroscopic machine, CT, MR, B ultrasonic).Interventional therapy is characterized in that wound is little, easy, safe, effective, few intercurrent disease and obviously shorten the hospital stays.
Apoplexy, also known as apoplexy, is a kind of cerebral blood circulation obstacle disease of unexpected onset.Clinical manifestation is the sings and symptoms of transient or permanent disordered brain function.Apoplexy is divided in ischemic cerebral apoplexy and hemorrhagic apoplexy.
The relation of left auricle, atrial fibrillation and apoplexy:
Left auricle is the remnants in embryonic stage original left atrium, in long and narrow, bending tube-like condition, has the ogival that is narrow.During sinus rhythm, left auricle seldom forms thrombosis because having normal contraction ability.During atrial fibrillation, left auricle entrance is obviously broadening, and spherical in shape or hemispherical changes, and loses the contraction of effective rule, and the introversive movement of auricle wall is difficult to cause enough left auricle emptying, causes blood to deposit at left auricle, and then thrombosed pathologic basis.In addition, Morphological Features and the interior trabecular muscles thereof of left auricle self are uneven, and easily making blood flow produce whirlpool and flows decrease, is also impel thrombotic condition.Thrombosis in patients with atrial fibrillation left auricle mainly comprises spontaneous video picture (SEC), mud sample changes (Sludge) and thrombosis (Thrombosis) three phases.Research finds, in this course, left auricle structure increases in various degree, blood flow rate and each wall movement velocity all reduce, thrombotic danger increases gradually, and constantly increase with left auricle, it fills and intestine evacuation velocity reduces gradually, and prompting left auricle structure and fuction changes linearly negative correlation.Research prompting, the rheumatic heart disease patients with atrial fibrillation heart source property thrombosis of 60% is from left auricle, and in Non-valvular disease patients with atrial fibrillation, more than 90% thrombosis is in left auricle.Therefore, intervene left auricle prevention patients with atrial fibrillation thromboembolism, especially apoplexy, has important theoretical foundation and clinical meaning.
For patients with atrial fibrillation, the selection faced clinically is now anticoagulant or left atrial appendage occlusion art.
Anticoagulation process of taking medicine is very long, and effect limitation.Even if effect is perfect, also all cannot apply, have at least the patient of 20% ~ 25% cannot Long-term Oral anticoagulation.
From calendar year 2001, the treatment of percutaneous left atrial appendage occlusion successively in animals, the person has carried out experimentation.Early stage research uses ACP occluder for left auricle (Fig. 1), has WATCHMAN occluder for left auricle (Fig. 2) afterwards, LamBre occluder for left auricle (Fig. 3).Be no matter ACP occluder for left auricle or WATCHMAN occluder for left auricle and LamBre occluder for left auricle, all confirm the feasibility of this technology, safety and effectiveness.
By experiment and the use in early stage, also expose some limitation of above product, as:
1, can not be completely recyclable;
Occluder for left auricle shown in Fig. 1, Fig. 2, when reclaiming into sheath pipe, its mooring anchor thorn can be stuck in sheath tube head end, can not enter sheath pipe completely, as shown in Figure 4.
2, bad from centrality;
Occluder for left auricle shown in Fig. 3, by several elastic supporting bars, occluder for left auricle is fixed on left auricle completely, when off-position is improper, shutoff dish there will be skew, and as shown in Figure 5, the thrombosis inside left auricle has the risk run out of.
3, mooring anchor thorn is fixing unreliable;
Occluder for left auricle shown in Fig. 3, elastic supporting bar support force is weak, and mooring anchor thorn is soft, and when there is atrial fibrillation, apparatus has the whole risk come off from left auricle.
Summary of the invention
It is completely recyclable that technical problem to be solved by this invention is to provide one, good from centrality, fixing reliable, shutoff implantable cavity plugging device completely, of the prior artly best plugging effect can not be reached as occluder for left auricle to solve, fixing unstable at left auricle cavity, and can not the problems such as resetting be realized.
Solving technical scheme of the present invention is: a kind of biological cavities plugging device, and for shutoff one biological cavities, described biological cavities comprises a leg and an entrance, and described biological cavities plugging device comprises:
One plugging structure, for this entrance of shutoff; At least two holder part, are carried on described plugging structure, and the described at least two at least part of regions of holder part abut described leg, and to prevent described plugging structure from coming off, and described holder part has the polygon three-dimensional shape of closed hollow.
According to device described above the cavity that is suitable for comprise a leg and an entrance, such as left auricle, atrial septal defect, ventricular septal defect etc.According to an embodiment, device described above the cavity that is suitable for when being left auricle, described entrance is the entrance that left auricle connects atrium, and described leg is the sidewall tissue of left auricle.Plugging structure can comprise such as metal, alloy, polyester, other biological biocompatible polymeric body material or its combination.Plugging structure essence is a disk-like structure, adopts B alloy wire etc. to form the fixing netted braiding structure in two ends by the mode of braiding.Prevent as thrombosis etc. the situation such as to deviate from from left auricle containing choked flow film in plugging structure, its rear end has a threaded bolt head to be connected with induction system.
At least two holder part, carry plugging structure, the at least two at least part of regions of holder part abut described leg, to prevent plugging structure for some reason as atrial fibrillation comes off, then thermal finalization is cut or woven to holder part by elastic metal material is U-shaped, therefore holder part has elastic force, abuts the cavity legs such as left auricle through elastic force.And holder part has the polygon three-dimensional shape of closed hollow, can be rhombus, triangular form, water-drop-shaped etc. or its combinative structure etc. can increase the structure of the stability of holder part.According to an embodiment, the polygon three-dimensional shape of this closed hollow is a rhombic supporting grid.From plugging structure, it is inner that rhombic supporting grid extends into described biological cavities with arcuate motion, the mid portion of arc abuts described biological cavities leg, and rhombic supporting grid has two or more, the expansion and the extension of plural rhombic supporting grid in biological cavities takes the shape of the letter U in fact jointly.Holder part comprises developing unit further as platinumiridio, tantalum, tungsten etc.
According at least two holder part of above-mentioned plugging device, more comprise the fixed projection chimeric with cavity leg, extend towards close to shutoff dish direction, to thrust the tissue of biological cavities leg, avoid described plugging structure to come off.According to an embodiment, above-mentioned fixed projection is a mooring anchor thorn, and be formed as anti-U-shaped by mould, there is an outside angle at its tip, and this angle is less than 90 degree, and the top of anti-U-shaped is a circular arc; Anchor thorn and holder part form one by integral cutting or welding or riveted joint, and the number of mooring anchor thorn is passed through integral cutting or welding with holder part or rivet node consistent, is more than or equal to two; Its position can be positioned at the bottom of holder part near plugging structure, centre position, or away from the top of plugging structure.
According to plugging device described above, at least two holder part are connected by flexibility or rigidity with plugging structure, and flexibly connecting can be by closed-loop, spring, two parts connect by soft braid over braids etc., and being rigidly connected can be connected by two parts by steel bushing etc.At least two holder part are launched towards leg direction relative to plugging structure one centre position, be convenient to abut with cavity leg better when plugging device is delivered in cavity by induction system, and two holder part cave inward towards this centre position near the bottom of plugging structure, be convenient at least two holder part with the flexibility or rigidity of plugging structure be connected.Leg tissue is stabbed away from the top of plugging structure for avoiding at least two holder part, therefore at least two holder part are each other away from the geometry diameter that the top of plugging structure is formed, and are less than the geometry diameter that at least two holder part are formed near the bottom of plugging structure each other.
One of invention embodiment still provides the method with above-mentioned plugging device shutoff left auricle.Method comprises when complete cavity plugging device has been equipped, by the connecting thread bolt head of plugging structure rear end during operation, through delivery sheath, the cavity plugging devices such as occluder for left auricle are delivered in the cavitys such as left auricle, fixed support part is opened, mooring anchor thorn is stuck in the sidewall muscular tissue of left auricle etc., withdraw delivery sheath, plugging structure is opened and is positioned at the porch of left auricle and left atrium, thus shutoff left auricle.
Method also comprises the confirmation of the shutoff to left auricle etc. further, whether suitable whether enters left auricle chamber, position by image documentation equipment observation fixed support.By pulling the conveying wirerope connecting plugging device, whether determining device is fixing reliable.By ultrasonic or radiography, determine whether shutoff dish shelters from the porch of left auricle completely.。Method further comprises the release to plugging device, when confirming occluder for left auricle position suitable, backs out conveying wirerope, release occluder for left auricle.
Method further comprise to the adjustment of plugging device with withdraw from, before conveying wirerope is backed out, as occurred, placement location is improper, then limit is returned and pulled conveying wirerope, and limit up pushes delivery sheath, shutoff dish is reclaimed completely into delivery sheath, then continue up to send sheath pipe, until the position stung to mooring anchor, now, mooring anchor thorn is complete to be deviate from from the cardiac muscle of left auricle, can carry out the adjustment of instrument positions; As model specification select to need to withdraw from occluder for left auricle when improper or operative failure time, namely need completely occluder for left auricle to be reclaimed to take out into sheath Guan Zhonghou, now continue conveying wirerope of pulling back, up send sheath pipe, now, whole occluder for left auricle, by reclaiming in delivery sheath completely, is withdrawn from external by delivery sheath by whole occluder for left auricle completely.
This plugging device has many advantages.Relative to prior art, having some limitations property, as:
1, can not be completely recyclable;
Occluder for left auricle shown in Fig. 1, Fig. 2, when reclaiming into sheath pipe, its mooring anchor thorn can be stuck in sheath tube head end, can not enter sheath pipe completely, as shown in Figure 4.In the present invention, when exiting plugging device, mooring anchor thorn is complete to be deviate from from the cardiac muscle of left auricle, the adjustment of instrument positions can be carried out, and mooring anchor thorn is anti-U-shaped design, there will not be above mooring anchor thorn can be stuck in sheath tube head end, thus the problem that can not reclaim completely;
2, bad from centrality;
Occluder for left auricle shown in Fig. 3, by several elastic supporting bars, occluder for left auricle is fixed on left auricle completely, when off-position is improper, shutoff dish there will be skew, and as shown in Figure 5, the thrombosis inside left auricle has the risk run out of.Adopt in the present invention be the polygon three-dimensional shape of resilient closed hollow as rhombus, triangular form, the protection support lattices such as water-drop-shaped etc. or its combinative structure can increase the stability of holder part.From plugging structure, it is inner that rhombic supporting grid extends into described biological cavities with arcuate motion, the mid portion of arc abuts described biological cavities leg, and rhombic supporting grid has two or more, the expansion and the extension of plural rhombic supporting grid in biological cavities takes the shape of the letter U in fact jointly, comprehensive abutting left auricle leg;
3, mooring anchor thorn is fixing unreliable;
Occluder for left auricle shown in Fig. 3, elastic supporting bar support force is weak, and mooring anchor thorn is soft, and when there is atrial fibrillation, apparatus has the whole risk come off from left auricle.In the present invention, anchor thorn and holder part are passed through integral cutting or welding or riveted joint and are formed one, the number of mooring anchor thorn with and holder part pass through integral cutting or welding or rivet node consistent, be more than or equal to two, and extend towards close to shutoff dish direction, thrust the tissue of biological cavities leg, avoid described plugging structure to come off.
Accompanying drawing explanation
Fig. 1 is ACP occluder for left auricle schematic diagram in prior art.
Fig. 2 is WATCHMAN occluder for left auricle schematic diagram in prior art.
Fig. 3 is LamBre occluder for left auricle schematic diagram in prior art.
Fig. 4 is the occluder for left auricle shown in Fig. 1, Fig. 2, and when reclaiming into sheath pipe, its mooring anchor thorn can be stuck in sheath tube head end, can not enter the schematic diagram of sheath pipe completely.
Fig. 5 be in prior art occluder for left auricle due to off-position improper time, shutoff dish there will be the schematic diagram of the situation of skew.
Fig. 6 is the side view of occluder for left auricle first embodiment of the present invention.
Fig. 7 is the support bracket fastened side view in occluder for left auricle first embodiment of the present invention after heat treatment shaping.
Fig. 8 is the flat side view that in occluder for left auricle first embodiment of the present invention, fixed support illustrates under cut state.
Fig. 9 is the side view of the mooring anchor thorn forming an outside angle in occluder for left auricle first embodiment of the present invention at tip.
Figure 10 is the side view through the shutoff dish of braiding formation in occluder for left auricle first embodiment of the present invention.
Figure 11 is the front view that in occluder for left auricle first embodiment of the present invention, tail end connects the shutoff dish of a threaded bolt head.
Figure 12 to close choked flow film at shutoff dish inseam in occluder for left auricle first embodiment of the present invention, forms the front view of complete occluder for left auricle.
Figure 13 is the schematic diagram in the first embodiment, occluder for left auricle being delivered to left auricle.
Figure 14 is that fixed support stings the schematic diagram be stuck in left auricle by mooring anchor in the first embodiment.
Figure 15 is the schematic diagram discharging shutoff dish after confirming support bracket fastened position in the first embodiment.
Mooring anchor is stung the schematic diagram deviate from from the cardiac muscle of left auricle in the first embodiment by Figure 16.
Whole occluder for left auricle is reclaimed the schematic diagram into delivery sheath in the first embodiment by Figure 17 completely.
Figure 18 is the side view of occluder for left auricle second embodiment of the present invention.
Figure 19 is the flat side view that in occluder for left auricle second embodiment of the present invention, fixed support illustrates under cut state.
Figure 20 is the side view of the mooring anchor thorn forming an outside angle in occluder for left auricle second embodiment of the present invention at tip.
Figure 21 is the support bracket fastened side view in occluder for left auricle second embodiment of the present invention after heat treatment shaping.
Figure 22 to close choked flow film at shutoff dish inseam in occluder for left auricle second embodiment of the present invention, forms the front view of complete occluder for left auricle.
Figure 23 is the side view of occluder for left auricle of the present invention 3rd embodiment.
Figure 24 is the side view first going out independent rhombic supporting bar in occluder for left auricle of the present invention 3rd embodiment with mould shape.
Figure 25 is the side view of the mooring anchor thorn forming an outside angle in occluder for left auricle of the present invention 3rd embodiment at tip.
Figure 26 is the support bracket fastened side view in occluder for left auricle of the present invention 3rd embodiment after steel bushing riveted joint.
Figure 27 is through the side view of universal connecting ring through the head end of shutoff dish in occluder for left auricle of the present invention 3rd embodiment.
Figure 28 to close choked flow film at shutoff dish inseam in occluder for left auricle of the present invention 3rd embodiment, forms the front view of complete occluder for left auricle.
Detailed description of the invention
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with drawings and Examples, the present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
Below in conjunction with accompanying drawing and multiple specific embodiment, the present invention is described in further details.
First embodiment:
The shutoff dish (2) that the occluder for left auricle (Fig. 6) of first embodiment of the invention comprises flexible fastening support (1), is connected with fixed support.Wherein this fixed support comprises closed-loop (111), rhombic supporting bar (112), mooring anchor thorn (3) closed one end.The NiTi pipe cutting of this fixed support, forms the structure of hollow out; NiTi pipe after cutting forms shape as shown in Figure 8, and now, mooring anchor thorn is towards support bracket fastened opening.After cutting, NiTi pipe expands into U-shaped by mould, mooring anchor transfixation is crossed mould and is formed the U-shaped contrary with fixed support, now the tip of mooring anchor thorn is towards support bracket fastened blind end, and forms an outside angle at the tip of mooring anchor thorn, as shown in Figure 9; Heat treatment shaping, as shown in Figure 7, mooring anchor thorn is positioned at U-shaped support bracket fastened bottom to the fixed support after sizing.Shutoff dish adopts nitinol alloy wire to form shape as shown in Figure 10 by the mode woven, and is then plate-like by mould through heat treatment shaping.A threaded bolt head (114) is connected, as shown in figure 11 at the tail end of plate-like.Stereotyped fixed support and shutoff dish steel bushing (115) are welded together.To close choked flow film (116) at shutoff dish inseam, form complete occluder for left auricle, as shown in figure 12.When operation uses, through the track to left atrium (50) set up, through delivery sheath (30), occluder for left auricle is delivered in left auricle (51), as shown in figure 13; Fixing conveying wirerope (31), withdraws delivery sheath (30), release fixed support, fixed support after release is stuck in left auricle by mooring anchor thorn, as Figure 14, observe support bracket fastened position by image documentation equipment, if suitable, release shutoff dish, as Figure 15, reaffirm that whether occluder for left auricle position is suitable, if suitable, back out conveying wirerope, release occluder for left auricle.If there is 1, off-position is improper; 2, model specification selects mistake; 3, need when operative failure to withdraw from occluder for left auricle, at this moment, 1, limit returns and pull conveying wirerope, limit up pushes delivery sheath, reclaims shutoff dish into delivery sheath completely; 2, continue up to send sheath pipe, until the position stung to mooring anchor, now, mooring anchor thorn is complete to be deviate from from the cardiac muscle of left auricle, can carry out the adjustment of instrument positions, as shown in figure 16.3, when needs completely occluder for left auricle is reclaimed carry out again discharging or taking out into sheath Guan Zhonghou time, continue conveying wirerope of pulling back, up send sheath pipe, now, whole occluder for left auricle will reclaim in delivery sheath completely, and the shape of mooring anchor thorn in sheath pipe as shown in figure 17.
Second embodiment:
The shutoff dish (2) that the occluder for left auricle (Figure 18) of second embodiment of the invention comprises flexible fastening support (1), is connected with fixed support.Wherein this fixed support comprises closed-loop (111), rhombic supporting bar (112), mooring anchor thorn (3) closed one end.The NiTi pipe cutting of this fixed support, forms the structure of hollow out; NiTi pipe after cutting forms shape as shown in figure 19, and now, mooring anchor thorn is towards support bracket fastened opening.After cutting, NiTi pipe expands into U-shaped by mould, mooring anchor transfixation is crossed mould and is formed the U-shaped contrary with fixed support, now the tip of mooring anchor thorn is towards support bracket fastened blind end, and forms an outside angle at the tip of mooring anchor thorn, as shown in figure 20; Heat treatment shaping, as shown in figure 21, mooring anchor thorn is positioned at U-shaped support bracket fastened top to the fixed support after sizing.Shutoff dish adopts nitinol alloy wire to form shape as shown in Figure 10 by the mode woven, and is then plate-like by mould through heat treatment shaping.A threaded bolt head (114) is connected, as shown in figure 11 at the tail end of plate-like.Stereotyped fixed support and shutoff dish steel bushing (115) are welded together.To close choked flow film (116) at shutoff dish inseam, form complete occluder for left auricle, as shown in figure 22.
3rd embodiment:
The shutoff dish (2) that the occluder for left auricle (Figure 23) of third embodiment of the invention comprises flexible fastening support (1), is connected with fixed support.Wherein this fixed support comprises closed-loop (111), rhombic supporting bar (112), mooring anchor thorn (3) closed one end.The braiding of this fixed support titanium-nickel wire forms.When fixed support makes, first go out independent rhombic supporting bar with mould shape, as shown in figure 24; Finalize mooring anchor thorn, as shown in figure 25; Rhombic supporting bar and mooring anchor transfixation are crossed steel bushing (118) be riveted together, form the fixed support of U-shaped, as shown in figure 26; Mooring anchor thorn is positioned at U-shaped support bracket fastened centre, towards shutoff dish end.Shutoff dish adopts nitinol alloy wire to form shape as shown in Figure 10 by the mode woven, and is then plate-like by mould through heat treatment shaping.A threaded bolt head (114) is connected, as shown in figure 11 at the tail end of plate-like.By the head end of universal connecting ring as shown in figure 27 through shutoff dish, flexibly connect by being formed between closed-loop (111) and fixed support.To close choked flow film (116) at shutoff dish inseam, form complete occluder for left auricle, as shown in figure 28.
Flexibly connecting a variety of mode between shutoff dish and fixed support, as connected between shutoff dish and fixed support by connecting between shutoff dish and fixed support, with a soft braid over braid with spring, just no longer having described in detail in embodiments of the present invention.
The above is only the preferred embodiments of the present invention, not any pro forma restriction is done to the present invention, although the present invention discloses as above with preferred embodiment, but and be not used to limit the present invention, any those skilled in the art, not departing from the scope of technical solution of the present invention, the technology contents of above-mentioned announcement should be utilized to make a little change or be modified to the Equivalent embodiments of equivalent variations, in every case be the content not departing from technical solution of the present invention, according to any simple modification that technical spirit of the present invention is done above embodiment, equivalent variations and modification, all still belong in the scope of technical solution of the present invention.
Claims (25)
1. a biological cavities plugging device, for shutoff one biological cavities, described biological cavities comprises encloses
Wall and an entrance, described biological cavities plugging device comprises:
One plugging structure, for this entrance of shutoff;
At least two holder part, are carried on described plugging structure, and the described at least two at least part of regions of holder part abut described leg, and to prevent described plugging structure from coming off, and described holder part has the polygon three-dimensional shape of closed hollow.
2. biological cavities plugging device as claimed in claim 1, wherein said biological cavities is left auricle, and described entrance is the entrance that left auricle connects atrium, and described leg is the sidewall tissue of left auricle.
3. biological cavities plugging device as claimed in claim 1, the polygon three-dimensional shape of wherein said closed hollow is a rhombic supporting grid.
4. biological cavities plugging device as claimed in claim 3, wherein said rhombic supporting grid is from described plugging structure, and extend into described biological cavities with arcuate motion inner, the mid portion of described arc abuts described biological cavities leg.
5. biological cavities plugging device as claimed in claim 3, wherein said rhombic supporting grid has two or more, the expansion and the extension of plural described rhombic supporting grid in biological cavities takes the shape of the letter U in fact jointly.
6. biological cavities plugging device as claimed in claim 1, wherein said plugging structure is an essence disk-like structure.
7. biological cavities plugging device as claimed in claim 1, wherein said holder part has elastic force, abuts described leg through elastic force.
8. biological cavities plugging device as claimed in claim 1, more comprises fixed projection, and described fixed projection extends to close to shutoff dish direction, to thrust the tissue of biological cavities leg, avoids described plugging structure to come off.
9. biological cavities plugging device as claimed in claim 8, wherein, described fixed projection is a mooring anchor thorn.
10. biological cavities plugging device as claimed in claim 9, wherein, described mooring anchor thorn and holder part are by integral cutting or welding or rivet formation one.
11. biological cavities plugging devices as claimed in claim 9, wherein, described mooring anchor thorn is most advanced and sophisticated an outside angle.
12. biological cavities plugging devices as claimed in claim 9, wherein, described mooring anchor thorn is more than or equal to two.
13. biological cavities plugging devices as claimed in claim 9, wherein, described mooring anchor thorn is U-shaped, contrary with the U-shaped of described holder part.
14. biological cavities plugging devices as claimed in claim 9, wherein, a circular arc is arranged at the anti-U-shaped top of described mooring anchor thorn.
15. biological cavities plugging devices as claimed in claim 9, wherein, described mooring anchor thorn is positioned at the bottom of described holder part near described plugging structure.
16. biological cavities plugging devices as claimed in claim 9, wherein, described mooring anchor thorn is positioned at the centre position of described holder part.
17. biological cavities plugging devices as claimed in claim 9, wherein, described mooring anchor thorn is positioned at the top of described holder part away from described plugging structure.
18. biological cavities plugging devices as claimed in claim 1, wherein, described at least two holder part are launched towards described leg direction relative to plugging structure one centre position, and described two holder part cave inward towards this centre position near the bottom of plugging structure.
19. biological cavities plugging devices as claimed in claim 1, wherein, described at least two holder part are each other away from the geometry diameter that the top of described plugging structure is formed, and at least two holder part described in being less than are each other near the geometry diameter of the bottom of described plugging structure formation.
20. biological cavities plugging devices as claimed in claim 1, wherein, then thermal finalization is cut or woven to described holder part by elastic metal material is U-shaped.
21. biological cavities plugging devices as claimed in claim 1, wherein, described holder part is connected by flexibility or rigidity with described plugging structure.
22. biological cavities plugging devices as claimed in claim 1, wherein, described plugging structure is the netted braiding structure that two ends are fixed.
23. biological cavities plugging devices as claimed in claim 1, wherein, comprise choked flow film in described plugging structure.
24. biological cavities plugging devices as claimed in claim 1, wherein, comprising choked flow film rear end in described plugging structure has a threaded bolt head to be connected with induction system.
25. biological cavities plugging devices as claimed in claim 1, wherein, described holder part is with developing unit.
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| CN201410582090.XA CN104287804B (en) | 2014-10-27 | 2014-10-27 | Biological cavity blocking device |
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| CN201410582090.XA CN104287804B (en) | 2014-10-27 | 2014-10-27 | Biological cavity blocking device |
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| CN104287804A true CN104287804A (en) | 2015-01-21 |
| CN104287804B CN104287804B (en) | 2017-02-22 |
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| CN201410582090.XA Expired - Fee Related CN104287804B (en) | 2014-10-27 | 2014-10-27 | Biological cavity blocking device |
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| WO2017113646A1 (en) * | 2015-12-31 | 2017-07-06 | 先健科技(深圳)有限公司 | Left atrial appendage occluder |
| CN106923883A (en) * | 2015-12-31 | 2017-07-07 | 先健科技(深圳)有限公司 | Occluder for left auricle |
| CN106466196B (en) * | 2016-09-22 | 2023-11-07 | 杭州德诺电生理医疗科技有限公司 | Split type left auricle plugging device |
| CN106466196A (en) * | 2016-09-22 | 2017-03-01 | 杭州诺茂医疗科技有限公司 | A kind of split type occluder for left auricle |
| CN106510788A (en) * | 2016-12-12 | 2017-03-22 | 上海心玮医疗科技有限公司 | Left atrial appendage occlusion device |
| US11957577B2 (en) | 2017-01-19 | 2024-04-16 | 4C Medical Technologies, Inc. | Systems, methods and devices for delivery systems, methods and devices for implanting prosthetic heart valves |
| US11944537B2 (en) | 2017-01-24 | 2024-04-02 | 4C Medical Technologies, Inc. | Systems, methods and devices for two-step delivery and implantation of prosthetic heart valve |
| WO2018219151A1 (en) * | 2017-06-02 | 2018-12-06 | 上海微创医疗器械（集团）有限公司 | Medical apparatus |
| CN107126240A (en) * | 2017-06-08 | 2017-09-05 | 有研医疗器械（北京）有限公司 | A kind of occluder for left auricle and its application method |
| CN111867490B (en) * | 2018-02-14 | 2024-01-30 | 波士顿科学医学有限公司 | Occlusion medical device |
| CN111867490A (en) * | 2018-02-14 | 2020-10-30 | 波士顿科学医学有限公司 | Occlusive medical device |
| US11857441B2 (en) | 2018-09-04 | 2024-01-02 | 4C Medical Technologies, Inc. | Stent loading device |
| WO2021041831A1 (en) * | 2019-08-30 | 2021-03-04 | Boston Scientific Scimed, Inc. | Left atrial appendage implant with sealing disk |
| US11540838B2 (en) | 2019-08-30 | 2023-01-03 | Boston Scientific Scimed, Inc. | Left atrial appendage implant with sealing disk |
| CN114340516A (en) * | 2019-08-30 | 2022-04-12 | 波士顿科学医学有限公司 | Left atrial appendage implant with sealing disk |
| US11931253B2 (en) | 2020-01-31 | 2024-03-19 | 4C Medical Technologies, Inc. | Prosthetic heart valve delivery system: ball-slide attachment |
| US11903589B2 (en) | 2020-03-24 | 2024-02-20 | Boston Scientific Scimed, Inc. | Medical system for treating a left atrial appendage |
| CN114617603A (en) * | 2020-12-10 | 2022-06-14 | 先健科技(深圳)有限公司 | Plugging device |
| CN114617603B (en) * | 2020-12-10 | 2024-04-02 | 先健科技(深圳)有限公司 | Plugging device |
| CN112842434B (en) * | 2020-12-30 | 2022-07-22 | 杭州唯强医疗科技有限公司 | Intra-cavity blocking device |
| CN112842434A (en) * | 2020-12-30 | 2021-05-28 | 杭州唯强医疗科技有限公司 | Intra-cavity blocking device |
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