CN104274666A - Effervescent tablet for treating gynecological diseases - Google Patents

Effervescent tablet for treating gynecological diseases Download PDF

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Publication number
CN104274666A
CN104274666A CN201410531887.7A CN201410531887A CN104274666A CN 104274666 A CN104274666 A CN 104274666A CN 201410531887 A CN201410531887 A CN 201410531887A CN 104274666 A CN104274666 A CN 104274666A
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effervescent tablet
acid
parts
treatment
crude drug
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Pending
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CN201410531887.7A
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Chinese (zh)
Inventor
刘巴宁
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ZHONGSHAN BAIOU PHARMACEUTICAL Co Ltd
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ZHONGSHAN BAIOU PHARMACEUTICAL Co Ltd
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Priority to CN201410531887.7A priority Critical patent/CN104274666A/en
Publication of CN104274666A publication Critical patent/CN104274666A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/234—Cnidium (snowparsley)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/532—Agastache, e.g. giant hyssop
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/756—Phellodendron, e.g. corktree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/758—Zanthoxylum, e.g. pricklyash
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Insects & Arthropods (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention relates to the technical field of medical supplies and particularly to an effervescent tablet for treating gynecological diseases. The effervescent agent comprises 40% of raw material medicine, 40% of a disintegrant, 4% of a diluent and 16% of a lubricant, and the effervescent agent further comprises 0.2% of high valence silver ions; the effervescent agent provided by the invention is good in stability, and meanwhile is easy to store, transport and use and small in irritation, and has a significant effect on staphylococcus aureus, staphylococcus epidermidis, Neisseria gonorrhoeae, Escherichia coli, Candida albicans, group B streptococcus; and the effervescent agent provided by the invention has an obvious anti-inflammatory effect and has a notable curative effect on colpitis mycotica.

Description

Be used for the treatment of the effervescent tablet of gynaecopathia
Technical field
The present invention relates to field of medical article technology, specifically a kind of effervescent tablet being used for the treatment of gynaecopathia.
Background technology
Vaginitis is the general name of the multiple vaginal mucosa inflammatory disease that different pathogeny causes.The vagina of healthy women, due to anatomical structure, has natural defense function to the intrusion of pathogen, there will not be inflammation.Noting when cleaning pudendum every day, selecting the Feminine care solution of weak acid formula to be more suitable for.If just with clear water or alkaline bath gel cleaning pudendum, the natural defense function of vagina is damaged, and pathogen is easy to invade, thus causes vaginitis.Symptom often has special pruritus, leucorrhoea grow in quantity, has the discomfort such as abnormal flavour, causalgia.Cause colpitic pathogen a lot, comprise antibacterial, virus, protozoon, candidiasis, chlamydia etc., the bacterial vaginosis that mainly caused by various bacteria of modal vaginal infection, also has by infusorian and the microbial infection of Candida albicans clinically.
Effervescent tablet is a kind of novel tablet of Abroad in Recent Years Application and Development.The difference of it and conventional tablet, just be it also containing gas-producing disintegrant, after drinking-water put into by effervescent tablet, under the effect of gas-producing disintegrant, at once a large amount of bubble (carbon dioxide) is produced, make the rapid disintegrate of tablet and thawing, the bubble that disintegrate sometimes produces also can make tablet roll up and down in water, accelerates its disintegrate and thawing.The carbon dioxide produced during disintegration of tablet is partially dissolved in drinking-water, has the aesthetic feeling as soda pop when drinking-water is drunk in entrance.
Because effervescent tablet has very effect to the various disease for the treatment of, therefore develop a kind of effervescent tablet for the treatment of gynaecopathia very necessary.
Summary of the invention
The object of this invention is to provide a kind of effervescent tablet effectively treating gynaecopathia utilizing Chinese crude drug to prepare for raw material.
For achieving the above object, the technical solution used in the present invention is: a kind of effervescent tablet being used for the treatment of gynaecopathia, this effervescent comprises crude drug, disintegrating agent, diluent and lubricant, described crude drug, disintegrating agent, diluent and lubricant weight percentage ratio are: 40%:40%:4%:16%, comprise 2 ‰ high-valence state silver ions in addition;
Described crude drug is made up of the raw material of following parts by weight: Radix Sophorae Flavescentis 6-12 part, Pericarpium Zanthoxyli 4-6 part, Periostracum Cicadae 6-9 part, Rhizoma Paridis 7-11 part, Cortex Phellodendri 5-12 part, Fructus Kochiae 3-8 part, Radix Platycodonis 4-10 part, Fructus Cnidii 4-9 part, Herba Pogostemonis 5-9 part, Flos Chrysanthemi Indici 4-11 part.
Further: described crude drug is made up of the raw material of following parts by weight: Radix Sophorae Flavescentis 8-10 part, Pericarpium Zanthoxyli 4-6 part, Periostracum Cicadae 7-9 part, Rhizoma Paridis 8-10 part, Cortex Phellodendri 7-11 part, Fructus Kochiae 4-8 part, Radix Platycodonis 5-8 part, Fructus Cnidii 5-8 part, Herba Pogostemonis 5-9 part, Flos Chrysanthemi Indici 4-10 part.
Further: described disintegrating agent is made up of bronsted lowry acids and bases bronsted lowry, the ratio 1:1 both it, described acid is one or more in boric acid, tartaric acid, citric acid, malic acid, and described alkali is one or more in sodium bicarbonate, potassium bicarbonate, sodium carbonate, glycine.
Further: described diluent is one or more in lactose, mannitol, sorbitol.
Further: described lubricant is poly-ethanedioic acid or hydroxyl starch formats sodium.
Advantageous Effects of the present invention is: good stability of the present invention, and simultaneously, be easy to store, transport and use, zest is little; To gold-coloured staphylococci, staphylococcus epidermidis, gonococcus, escherichia coli, candida albicans, group B streptococcus, there is significant effect; Effervescent of the present invention has obvious antiinflammatory action, remarkable to colpitis mycotica therapeutic effect.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment 1
Be used for the treatment of an effervescent tablet for gynaecopathia, this effervescent comprises crude drug, disintegrating agent, diluent and lubricant, and its percentage by weight is: 40%:40%:4%:16%, comprises 2 ‰ high-valence state silver ions in addition.
Crude drug is made up of the raw material of following parts by weight: Radix Sophorae Flavescentis 6 parts, 6 parts, Pericarpium Zanthoxyli, Periostracum Cicadae 6 parts, Rhizoma Paridis 11 parts, Cortex Phellodendri 5 parts, the Fructus Kochiae 8 parts, Radix Platycodonis 4 parts, Fructus Cnidii 9 parts, Herba Pogostemonis 5 parts, Flos Chrysanthemi Indici 11 parts.
Disintegrating agent is made up of bronsted lowry acids and bases bronsted lowry, the ratio 1:1 both it; Acid is one or more in boric acid, tartaric acid, citric acid, malic acid; Alkali is one or more in sodium bicarbonate, potassium bicarbonate, sodium carbonate, glycine.
Diluent is one or more in lactose, mannitol, sorbitol.
Lubricant is poly-ethanedioic acid or hydroxyl starch formats sodium.
Embodiment 2
Be used for the treatment of an effervescent tablet for gynaecopathia, this effervescent comprises crude drug, disintegrating agent, diluent and lubricant, and its percentage by weight is: 40%:40%:4%:16%, comprises 2 ‰ high-valence state silver ions in addition.
Crude drug is made up of the raw material of following parts by weight: Radix Sophorae Flavescentis 12 parts, 4 parts, Pericarpium Zanthoxyli, Periostracum Cicadae 9 parts, Rhizoma Paridis 7 parts, Cortex Phellodendri 12 parts, the Fructus Kochiae 3 parts, Radix Platycodonis 10 parts, Fructus Cnidii 4 parts, Herba Pogostemonis 9 parts, Flos Chrysanthemi Indici 4 parts.
Disintegrating agent is made up of bronsted lowry acids and bases bronsted lowry, the ratio 1:1 both it, and acid is one or more in boric acid, tartaric acid, citric acid, malic acid, and alkali is one or more in sodium bicarbonate, potassium bicarbonate, sodium carbonate, glycine.
Diluent is one or more in lactose, mannitol, sorbitol.
Lubricant is poly-ethanedioic acid or hydroxyl starch formats sodium.
Embodiment 3
Be used for the treatment of an effervescent tablet for gynaecopathia, this effervescent comprises crude drug, disintegrating agent, diluent and lubricant, and its percentage by weight is: 40%:40%:4%:16%, comprises 2 ‰ high-valence state silver ions in addition.
Crude drug is made up of the raw material of following parts by weight: Radix Sophorae Flavescentis 8 parts, 6 parts, Pericarpium Zanthoxyli, Periostracum Cicadae 7 parts, Rhizoma Paridis 10 parts, Cortex Phellodendri 7 parts, the Fructus Kochiae 8 parts, Radix Platycodonis 5 parts, Fructus Cnidii 8 parts, Herba Pogostemonis 5 parts, Flos Chrysanthemi Indici 10 parts.
Disintegrating agent is made up of bronsted lowry acids and bases bronsted lowry, the ratio 1:1 both it, and acid is one or more in boric acid, tartaric acid, citric acid, malic acid, and alkali is one or more in sodium bicarbonate, potassium bicarbonate, sodium carbonate, glycine.
Diluent is one or more in lactose, mannitol, sorbitol.
Lubricant is poly-ethanedioic acid or hydroxyl starch formats sodium.
Embodiment 4
Be used for the treatment of an effervescent tablet for gynaecopathia, this effervescent comprises crude drug, disintegrating agent, diluent and lubricant, and its percentage by weight is: 40%:40%:4%:16%, comprises 2 ‰ high-valence state silver ions in addition
Crude drug is made up of the raw material of following parts by weight: Radix Sophorae Flavescentis 10 parts, 4 parts, Pericarpium Zanthoxyli, Periostracum Cicadae 9 parts, Rhizoma Paridis 8 parts, Cortex Phellodendri 11 parts, the Fructus Kochiae 4 parts, Radix Platycodonis 8 parts, Fructus Cnidii 5 parts, Herba Pogostemonis 9 parts, Flos Chrysanthemi Indici 4 parts.
Disintegrating agent is made up of bronsted lowry acids and bases bronsted lowry, the ratio 1:1 both it, and acid is one or more in boric acid, tartaric acid, citric acid, malic acid, and alkali is one or more in sodium bicarbonate, potassium bicarbonate, sodium carbonate, glycine.
Diluent is one or more in lactose, mannitol, sorbitol.
Lubricant is poly-ethanedioic acid or hydroxyl starch formats sodium.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (5)

1. be used for the treatment of the effervescent tablet of gynaecopathia, this effervescent comprises crude drug, disintegrating agent, diluent and lubricant, it is characterized in that: described crude drug, disintegrating agent, diluent and lubricant weight percentage ratio are: 40%:40%:4%:16%, comprise 2 ‰ high-valence state silver ions in addition;
Described crude drug is made up of the raw material of following parts by weight: Radix Sophorae Flavescentis 6-12 part, Pericarpium Zanthoxyli 4-6 part, Periostracum Cicadae 6-9 part, Rhizoma Paridis 7-11 part, Cortex Phellodendri 5-12 part, Fructus Kochiae 3-8 part, Radix Platycodonis 4-10 part, Fructus Cnidii 4-9 part, Herba Pogostemonis 5-9 part, Flos Chrysanthemi Indici 4-11 part.
2. be used for the treatment of the effervescent tablet of gynaecopathia according to claim 1, it is characterized in that: described crude drug is made up of the raw material of following parts by weight: Radix Sophorae Flavescentis 8-10 part, Pericarpium Zanthoxyli 4-6 part, Periostracum Cicadae 7-9 part, Rhizoma Paridis 8-10 part, Cortex Phellodendri 7-11 part, Fructus Kochiae 4-8 part, Radix Platycodonis 5-8 part, Fructus Cnidii 5-8 part, Herba Pogostemonis 5-9 part, Flos Chrysanthemi Indici 4-10 part.
3. be used for the treatment of the effervescent tablet of gynaecopathia according to claim 1, it is characterized in that: described disintegrating agent is made up of bronsted lowry acids and bases bronsted lowry, ratio 1:1 both it, described acid is one or more in boric acid, tartaric acid, citric acid, malic acid, and described alkali is one or more in sodium bicarbonate, potassium bicarbonate, sodium carbonate, glycine.
4. be used for the treatment of the effervescent tablet of gynaecopathia according to claim 1, it is characterized in that: described diluent is one or more in lactose, mannitol, sorbitol.
5. be used for the treatment of the effervescent tablet of gynaecopathia according to claim 1, it is characterized in that: described lubricant is poly-ethanedioic acid or hydroxyl starch formats sodium.
CN201410531887.7A 2014-10-11 2014-10-11 Effervescent tablet for treating gynecological diseases Pending CN104274666A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109957528A (en) * 2017-12-26 2019-07-02 大连医科大学 Immunity-regulating tolerance development delays the bacterial strain of allergia process

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1546126A (en) * 2003-11-28 2004-11-17 温先敏 Externally applied medical lotion for treating gynecopathy and its preparing process
CN101244187A (en) * 2008-02-02 2008-08-20 温先敏 Suppository for treating gynaecologic disease
CN101417072A (en) * 2008-11-25 2009-04-29 温先敏 Effervescence tablet for treating gynecologic disease
CN102755426A (en) * 2012-07-10 2012-10-31 李顺祥 Chinese medicament for treating gynecological inflammation and preparation method

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1546126A (en) * 2003-11-28 2004-11-17 温先敏 Externally applied medical lotion for treating gynecopathy and its preparing process
CN101244187A (en) * 2008-02-02 2008-08-20 温先敏 Suppository for treating gynaecologic disease
CN101417072A (en) * 2008-11-25 2009-04-29 温先敏 Effervescence tablet for treating gynecologic disease
CN102755426A (en) * 2012-07-10 2012-10-31 李顺祥 Chinese medicament for treating gynecological inflammation and preparation method

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
王世兰: "中药熏洗治疗少女阴部瘙痒症", 《辽宁中医学院学报》 *
韦秀兰: "蛇参汤治疗女阴瘙痒症近期疗效观察", 《四川中医》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109957528A (en) * 2017-12-26 2019-07-02 大连医科大学 Immunity-regulating tolerance development delays the bacterial strain of allergia process

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