CN104274505B - 一种独活止痛搽剂的制备方法 - Google Patents
一种独活止痛搽剂的制备方法 Download PDFInfo
- Publication number
- CN104274505B CN104274505B CN201410560538.8A CN201410560538A CN104274505B CN 104274505 B CN104274505 B CN 104274505B CN 201410560538 A CN201410560538 A CN 201410560538A CN 104274505 B CN104274505 B CN 104274505B
- Authority
- CN
- China
- Prior art keywords
- radix angelicae
- angelicae pubescentis
- volatile oil
- liniment
- pain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229940040145 liniment Drugs 0.000 title claims abstract description 15
- 239000000865 liniment Substances 0.000 title claims abstract description 15
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 239000000341 volatile oil Substances 0.000 claims abstract description 32
- 241000220317 Rosa Species 0.000 claims abstract description 6
- 238000001914 filtration Methods 0.000 claims abstract description 5
- 241000125175 Angelica Species 0.000 claims description 19
- 235000001287 Guettarda speciosa Nutrition 0.000 claims description 19
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 18
- 239000010413 mother solution Substances 0.000 claims description 13
- 239000003921 oil Substances 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 239000012567 medical material Substances 0.000 claims description 10
- 238000000108 ultra-filtration Methods 0.000 claims description 8
- 239000000730 antalgic agent Substances 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- 238000000605 extraction Methods 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 239000012467 final product Substances 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 238000005057 refrigeration Methods 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 4
- 238000009413 insulation Methods 0.000 claims description 4
- 229910000831 Steel Inorganic materials 0.000 claims description 3
- 235000012489 doughnuts Nutrition 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 229910017053 inorganic salt Inorganic materials 0.000 claims description 3
- 239000012266 salt solution Substances 0.000 claims description 3
- 239000010959 steel Substances 0.000 claims description 3
- 238000011049 filling Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 4
- 239000012528 membrane Substances 0.000 abstract description 2
- 239000000835 fiber Substances 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 7
- 239000000047 product Substances 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000001256 steam distillation Methods 0.000 description 3
- 238000000194 supercritical-fluid extraction Methods 0.000 description 3
- 102000002322 Egg Proteins Human genes 0.000 description 2
- 108010000912 Egg Proteins Proteins 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 206010050031 Muscle strain Diseases 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 description 2
- 239000012510 hollow fiber Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 210000003041 ligament Anatomy 0.000 description 2
- 238000000874 microwave-assisted extraction Methods 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 description 1
- 239000001500 (2R)-6-methyl-2-[(1R)-4-methyl-1-cyclohex-3-enyl]hept-5-en-2-ol Substances 0.000 description 1
- IQVQXVFMNOFTMU-FLIBITNWSA-N (Z)-ligustilide Chemical compound C1CC=CC2=C1C(=C/CCC)/OC2=O IQVQXVFMNOFTMU-FLIBITNWSA-N 0.000 description 1
- SIRPHJCQZYVEES-UHFFFAOYSA-N 1-methylbenzimidazole-2-carbaldehyde Chemical compound C1=CC=C2N(C)C(C=O)=NC2=C1 SIRPHJCQZYVEES-UHFFFAOYSA-N 0.000 description 1
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
- 206010009866 Cold sweat Diseases 0.000 description 1
- 241000125183 Crithmum maritimum Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- IQVQXVFMNOFTMU-DHZHZOJOSA-N Z-ligustilide Natural products C1CC=CC2=C1C(=C/CCC)\OC2=O IQVQXVFMNOFTMU-DHZHZOJOSA-N 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000001741 anti-phlogistic effect Effects 0.000 description 1
- 210000000544 articulatio talocruralis Anatomy 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000014103 egg white Nutrition 0.000 description 1
- 210000000969 egg white Anatomy 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 210000000548 hind-foot Anatomy 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 210000004681 ovum Anatomy 0.000 description 1
- OIGWAXDAPKFNCQ-UHFFFAOYSA-N p-Isopropylbenzyl alcohol Natural products CC(C)C1=CC=C(CO)C=C1 OIGWAXDAPKFNCQ-UHFFFAOYSA-N 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000000207 volumetry Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/02—Recovery or refining of essential oils from raw materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明属于中药技术领域，涉及一种独活止痛搽剂的制备方法。具体为采用新鲜独活采用水蒸气法获得独活挥发油，在向挥发油中加入玫瑰香精，并通过纤维滤膜进行过滤从而获得，所得独活止痛搽剂不仅活性好而且稳定性高。
Description
技术领域
本发明属于中药技术领域，涉及一种独活止痛搽剂的制备方法。
背景技术
独活止痛搽剂为伞形科植物独活经提取挥发油制成的搽剂，具有止痛、消肿、散瘀的作用。用于小关节挫伤，韧带、肌肉拉伤及风湿痛。本品为纯中药制剂，辅料为乙醇和玫瑰香精。
目前，独活止痛搽剂（见《中华人民共和国卫生部药品标准》·第十五册）的制法为取独活挥发油10g，加玫瑰香精10g，混匀，加入70％乙醇适量，搅匀，再用70％乙醇调整总量至1000ml，滤过，分装，即得。但是，此工艺中由于独活挥发油中含有大分子的物质（例如，蛋白）从而导致制剂容易浑浊，随着储存时间的延长会产生沉淀，从而影响制剂的稳定性。
另外，在现有技术中，独活挥发油的提取工艺主要有水蒸气蒸馏法、微波萃取法、超临界流体萃取法等，其中微波萃取法需要微波萃取装置，超临界流体萃取需要超临界萃取装置，相对成本较高，水蒸气蒸馏法简单，经典，容易操作，但产率一般较低。就目前而言，本领域中并不存在提取率较高的独活挥发油水蒸气蒸馏法的相关工艺。
发明内容
本发明的目的就是提供一种具有止痛、消肿、散瘀的作用。用于小关节挫伤，韧带、肌肉拉伤及风湿痛的外用药。因本品主要成份为独活挥发油，本发明同时提供了一种独活挥发油的提取方法。
本发明主要解决的问题：一、采用新鲜独活粉碎到最佳粒度，提高挥发油收率；二、对蒸馏后分离的母液采用盐析冷藏法，提高挥发油的收率；三、对配制好的药液采用中空纤维超滤法提高药液的澄清度及在贮藏过程中的稳定性。
本发明一种独活止痛搽剂的制备方法，其包括如下步骤：
（1）取新鲜独活药材，粉碎成粗粉，置多功能提取罐中，药材量为提取罐容积的1/4，加水润湿60分钟。从罐底通入蒸汽，加热，保持蒸汽压力0.12- 0.15Mpa，温度为100-120℃，蒸馏8小时，
（2）从油水分离器中分别接收独活挥发油和母液。母液收集在带冷凝装置的不锈钢贮罐中，加入无机盐溶液，使成浓度为5%，开启制冷机组，用冷水循环保温，使母液温度保持在2-10℃，保温12-24小时。收集上面的油层置油水分离器中，分取挥发油即得。
（3）取独活挥发油10g，加玫瑰香精10g，搅拌混匀，加入70%乙醇300g，搅拌混匀，再用70%乙醇调整总量至1000ml。经过板框过滤，滤膜孔径10μm，再经过超滤，材质：中空纤维，孔径10000道尔顿分子量。超滤完后的药液灌装，即得。
在本发明进一步地的实施方案中，在步骤（1）中，所述粉碎优选将药材粉碎成4-16目筛的粗粉，所述加水优选加入药材量1/10的水。
在步骤（2）中，所述无机盐溶液优选为氯化钠溶液，氯化钠的终浓度优选为5%（重量），母液温度优选为4℃，保温时间优选为16小时。
本发明与现有技术相比，具有如下所述的技术优势：
1、选用新鲜独活，粉碎成粗粉。新鲜独活挥发油含量高，粉碎成过8目筛的颗粒出油率最高，太粗挥发油不易蒸馏出，太细，药材会软化，发粘，同样不利于挥发油的蒸出。
2、油水分离器分离的母液中仍有部分挥发油，采用盐析冷藏法分离母液中的挥发油，提高了挥发油的收率。
3、配制好的药液采用孔径为10000道尔顿分子量中空纤维超滤，使药液澄清，同时在贮藏程中不会出现析油和浑浊现象，保证产品稳定性。
具体实施方式
下面将进一步的详细说明本发明。需要指出的是，以下说明仅仅是对本发明要求保护的技术方案的举例说明，并非对这些技术方案的任何限制。本发明的保护范围以所附权利要求书记载的内容为准。
实施例1
独活挥发油的提取：取新鲜独活药材，粉碎成过8目筛的粗粉，置多功能提取罐中，药材量为提取罐容积的1/4，加药材量1/10的水润湿60分钟。从罐底通入蒸汽，加热，保持蒸汽压力0.12-0.15Mpa，温度为100-120℃，蒸馏8小时，从油水分离器中分别接收独活挥发油和母液。母液收集在带冷凝装置的不锈钢贮罐中，加入氯化钠溶液，使成浓度为5%，开启制冷机组，用冷水循环保温，使母液温度保持在4℃，保温16小时。收集上面的油层置油水分离器中，分取挥发油即得（0.43%重量）。GC-MS分析测定表明所得独活挥发油中主要活性成分含量：蒿本内酯的含量为7.92%（重量）；4-异丙基苯甲醇7.36%（重量）；α-甜没药醇2.87%（重量）。
配料：取独活挥发油10g，加玫瑰香精10g，搅拌混匀，加入70%乙醇300g，搅拌混匀，再用70%乙醇调整总量至1000ml。
过滤及超滤：经过板框过滤，滤膜孔径10μm，再经过超滤，材质：中空纤维，孔径10000道尔顿分子量。
实施例2
采用不同工艺参数制备独活挥发油，除下表参数外，其他制备方法均同实施例1。
各工艺下独活挥发油得率和主要成分含量
实施例3
（1）采用蛋清致大鼠足肿胀模型考察实施例1和实施例2制备的独活挥发油的抗炎效果，试验方法为：取雄性SD大鼠，220g左右，在大鼠右后足踝关节做标记，按足容积测定法测定右后足容积。ig.给药独活挥发油50mg/kg，模型组给予等量的生理盐水。给药30min后，在大鼠右后足注射10%的鲜鸡蛋清溶液0.1ml致炎，在致炎后240min测定大鼠右后足容积，通过与造模前的足容积相比计算致炎后足肿程度，具体结果如下：
（2）采用醋酸致小鼠疼痛模型考察实施例1和实施例2制备的独活挥发油的止痛效果效果，具体方法为：取ICR小鼠，20g左右，ig给药3天，剂量为25mg/kg，末次给药后，分别ip给予0.2ml醋酸，观察记录注射醋酸后15min内的小鼠扭体次数，具体结果如下：
实施例4
采用不同孔径滤膜进行过滤分别制备独活止痛搽剂（除下表参数外其他制备方法同实施例1），高温高湿（45℃，相对湿度75%）储存3个月，采用GC-MS分别测定搽剂中的独活主要活性成分含量。
实施例1及对比例制备搽剂的主要成分含量（%）
本发明内容仅仅举例说明了要求保护的一些具体实施方案，其中一个或更多个技术方案中所记载的技术特征可以与任意的一个或多个技术方案相组合，这些经组合而得到的技术方案也在本申请保护范围内，就像这些经组合而得到的技术方案已经在本发明公开内容中具体记载一样。
Claims (1)
1. 一种独活止痛搽剂的制备方法，其包括如下步骤：
（1）取新鲜独活药材，粉碎成8目筛的粗粉，置多功能提取罐中，药材量为提取罐容积的1/4，加药材量1/10的水润湿60分钟；从罐底通入蒸汽，加热，保持蒸汽压力0.12- 0.15Mpa，温度为100-120℃，蒸馏8小时，
（2）从油水分离器中分别接收独活挥发油和母液；母液收集在带冷凝装置的不锈钢贮罐中，加入无机盐溶液，使成浓度为5%，开启制冷机组，用冷水循环保温，使母液温度保持在4℃，保温16小时；收集上面的油层置油水分离器中，分取挥发油即得；
（3）取独活挥发油10g，加玫瑰香精10g，搅拌混匀，加入70%乙醇300g，搅拌混匀，再用70%乙醇调整总量至1000ml；经过板框过滤，滤膜孔径10μm，再经过超滤，材质：中空纤维，孔径10000道尔顿分子量；超滤完后的药液灌装，即得。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410560538.8A CN104274505B (zh) | 2014-10-21 | 2014-10-21 | 一种独活止痛搽剂的制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410560538.8A CN104274505B (zh) | 2014-10-21 | 2014-10-21 | 一种独活止痛搽剂的制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104274505A CN104274505A (zh) | 2015-01-14 |
| CN104274505B true CN104274505B (zh) | 2015-06-24 |
Family
ID=52250167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410560538.8A Active CN104274505B (zh) | 2014-10-21 | 2014-10-21 | 一种独活止痛搽剂的制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104274505B (zh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105969526B (zh) * | 2016-05-20 | 2018-04-20 | 中发实业集团业锐药业有限公司 | 一种降香挥发油的提取方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6790464B2 (en) * | 2003-01-16 | 2004-09-14 | Healthaid Enterprise Pte. Ltd. | Herbal compositions for prostate conditions |
| CN101843663B (zh) * | 2010-05-20 | 2013-04-17 | 培力(南宁)药业有限公司 | 一种比水重的挥发油提取包裹制备方法 |
-
2014
- 2014-10-21 CN CN201410560538.8A patent/CN104274505B/zh active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN104274505A (zh) | 2015-01-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103877244B (zh) | 一种治疗头痛的药物组合物及其制备方法 | |
| CN100453094C (zh) | 中药复方通脉口服液有效部位的药物组合物及其制备方法 | |
| CN103416532B (zh) | 安神茶叶 | |
| CN105079308A (zh) | 一种走游草提取物，该提取物的制备方法及医药用途 | |
| CN102100758B (zh) | 一种用于止痛消肿的青鹏凝胶剂及其制备方法 | |
| CN104274505B (zh) | 一种独活止痛搽剂的制备方法 | |
| CN102302615B (zh) | 一种祖师麻叶有效部位群、其制备方法、药物组合物和应用 | |
| CN101156935A (zh) | 治疗偏头痛的植物活性成分组合物及其制备方法和应用 | |
| CN101780242A (zh) | 一种保健或药品组合物及其制备方法和用途 | |
| CN111375035B (zh) | 一种治疗颈椎病的肠溶制剂的制备及应用 | |
| CN105796961A (zh) | 陈皮和白茅根组合物在制备抗化疗呕吐药物中的用途 | |
| CN108514568A (zh) | 苍耳子中噻嗪类化合物的制备方法及其医药用途 | |
| KR101407889B1 (ko) | 진피 추출물을 유효성분으로 포함하는 염증성 질환 치료 및 예방용 조성물 | |
| CN105250348B (zh) | 一种用于消肿止痛的火把花根外用制剂、制备方法及其应用 | |
| CN107375829A (zh) | 治疗中风后抑郁症的中药组合物及其制剂的制备方法 | |
| CN101991568B (zh) | 洋川芎内酯i在制备抗抑郁症药物、偏头痛药物及其他5-羟色胺能系统相关疾病药物中的应用 | |
| CN105031329A (zh) | 一种治疗肝气郁结型偏头痛的中药制剂及其制备方法 | |
| CN106349109B (zh) | 一种抗炎止痒天然活性化合物及其制备方法与应用 | |
| CN101804128B (zh) | 一种治疗炎症性肠病的药物组合物及该组合物在制备治疗炎症性肠病药物中的用途 | |
| CN104922649B (zh) | 姜黄消痤外用制剂及其制备方法和用途 | |
| CN105012279A (zh) | 含奇壬醇的组合物及其在医药上的应用 | |
| CN104784354B (zh) | 一种治疗偏头痛的中药穴位注射液及其制备方法 | |
| CN103181957A (zh) | 一种能完全去除附子急性毒性并保留其药效活性的制备工艺 | |
| CN102293977B (zh) | 一种外用治疗痹证的中药物组合物及其制备方法和检测方法 | |
| RU2683643C1 (ru) | Способ получения водно-спиртового экстракта лекарственных растений, обладающего седативным и гипотензивным действием |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address | ||
| CP03 | Change of name, title or address |
Address after: 441003, 85 Deng Cheng Avenue, hi tech Development Zone, Hubei, Xiangyang Patentee after: Sunflower Pharmaceutical Group (Xiangyang) Co., Ltd. Longzhong Address before: 441003 Hubei city of Xiangfan province high tech Zone Dengcheng Road No. 85 Hubei Xiangyang Longzhong Pharmaceutical Group Co. Ltd. Patentee before: HUBEI XIANGYANG LONGZHONG PHARMACEUTICAL GROUP CO., LTD. |