CN104262277A - 含硝基和卤苯取代的四氮唑乙酸类化合物、其制备方法及用途 - Google Patents
含硝基和卤苯取代的四氮唑乙酸类化合物、其制备方法及用途 Download PDFInfo
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- CN104262277A CN104262277A CN201410526404.4A CN201410526404A CN104262277A CN 104262277 A CN104262277 A CN 104262277A CN 201410526404 A CN201410526404 A CN 201410526404A CN 104262277 A CN104262277 A CN 104262277A
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- 0 *C[n]1nnc(CCCN(c2cc(Cl)ccc2)c(c2c3cccc2)ccc3[N+]([O-])=O)n1 Chemical compound *C[n]1nnc(CCCN(c2cc(Cl)ccc2)c(c2c3cccc2)ccc3[N+]([O-])=O)n1 0.000 description 2
- QYJZBBYREDAQNG-UHFFFAOYSA-N [O-][N+](c(c1c2cccc1)ccc2N(CCCc1n[n](CC(O)=O)nn1)c1cc(F)ccc1)=O Chemical compound [O-][N+](c(c1c2cccc1)ccc2N(CCCc1n[n](CC(O)=O)nn1)c1cc(F)ccc1)=O QYJZBBYREDAQNG-UHFFFAOYSA-N 0.000 description 1
- RJTKXQQAOAOEAR-UHFFFAOYSA-N [O-][N+](c(c1c2cccc1)ccc2N(CCCc1n[n](CC(O)=O)nn1)c1ccccc1)=O Chemical compound [O-][N+](c(c1c2cccc1)ccc2N(CCCc1n[n](CC(O)=O)nn1)c1ccccc1)=O RJTKXQQAOAOEAR-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
Abstract
Description
化合物 | IC50(hURAT1,nM) |
实施例1化合物 | 5.2 |
实施例2化合物 | 15.1 |
实施例3化合物 | 7.5 |
实施例4化合物 | 10.8 |
实施例5化合物 | 13.9 |
实施例6化合物 | 11.4 |
实施例7化合物 | 8.9 |
实施例8化合物 | 14.4 |
实施例9化合物 | 17.3 |
实施例10化合物 | 15.6 |
Claims (5)
Priority Applications (1)
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CN201410526404.4A CN104262277B (zh) | 2014-10-07 | 2014-10-07 | 含硝基和卤苯取代的四氮唑乙酸类化合物、其制备方法及用途 |
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CN201410526404.4A CN104262277B (zh) | 2014-10-07 | 2014-10-07 | 含硝基和卤苯取代的四氮唑乙酸类化合物、其制备方法及用途 |
Publications (2)
Publication Number | Publication Date |
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CN104262277A true CN104262277A (zh) | 2015-01-07 |
CN104262277B CN104262277B (zh) | 2016-06-22 |
Family
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CN201410526404.4A Active CN104262277B (zh) | 2014-10-07 | 2014-10-07 | 含硝基和卤苯取代的四氮唑乙酸类化合物、其制备方法及用途 |
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CN (1) | CN104262277B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105820130A (zh) * | 2015-01-08 | 2016-08-03 | 天津药物研究院有限公司 | 三氮唑正丙酸类urat1抑制剂、制备方法及其在高尿酸血症和痛风治疗上的用途 |
CN106187926A (zh) * | 2015-04-30 | 2016-12-07 | 天津药物研究院有限公司 | 含二芳基甲烷结构的羧酸类urat1抑制剂、制备方法及其在高尿酸血症和痛风治疗上的用途 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1356977A (zh) * | 1999-05-17 | 2002-07-03 | 诺沃挪第克公司 | 胰高血糖素拮抗剂/反向激动剂 |
WO2008021804A2 (en) * | 2006-08-09 | 2008-02-21 | Allergan, Inc. | Therapeutic amides and related compounds |
WO2008062740A1 (fr) * | 2006-11-20 | 2008-05-29 | Japan Tobacco Inc. | Composé azoté à anneaux fusionnés et son utilisation |
EP1985297A1 (en) * | 2006-01-27 | 2008-10-29 | Japan Tobacco, Inc. | Carboxylic acid compound and use thereof |
CN102014898A (zh) * | 2008-04-30 | 2011-04-13 | 维尔斯达医疗公司 | 用于减少尿酸的四唑化合物 |
-
2014
- 2014-10-07 CN CN201410526404.4A patent/CN104262277B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1356977A (zh) * | 1999-05-17 | 2002-07-03 | 诺沃挪第克公司 | 胰高血糖素拮抗剂/反向激动剂 |
EP1985297A1 (en) * | 2006-01-27 | 2008-10-29 | Japan Tobacco, Inc. | Carboxylic acid compound and use thereof |
WO2008021804A2 (en) * | 2006-08-09 | 2008-02-21 | Allergan, Inc. | Therapeutic amides and related compounds |
WO2008062740A1 (fr) * | 2006-11-20 | 2008-05-29 | Japan Tobacco Inc. | Composé azoté à anneaux fusionnés et son utilisation |
CN102014898A (zh) * | 2008-04-30 | 2011-04-13 | 维尔斯达医疗公司 | 用于减少尿酸的四唑化合物 |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105820130A (zh) * | 2015-01-08 | 2016-08-03 | 天津药物研究院有限公司 | 三氮唑正丙酸类urat1抑制剂、制备方法及其在高尿酸血症和痛风治疗上的用途 |
CN105820130B (zh) * | 2015-01-08 | 2018-06-22 | 天津药物研究院有限公司 | 三氮唑正丙酸类urat1抑制剂、制备方法及其在高尿酸血症和痛风治疗上的用途 |
CN106187926A (zh) * | 2015-04-30 | 2016-12-07 | 天津药物研究院有限公司 | 含二芳基甲烷结构的羧酸类urat1抑制剂、制备方法及其在高尿酸血症和痛风治疗上的用途 |
CN106187926B (zh) * | 2015-04-30 | 2018-11-27 | 天津药物研究院有限公司 | 含二芳基甲烷结构的羧酸类urat1抑制剂、制备方法及其在高尿酸血症和痛风治疗上的用途 |
AU2016253911B2 (en) * | 2015-04-30 | 2019-12-05 | Tianjin Institute Of Pharmaceutical Research Co., Ltd. | Carboxylic acid URAT1 inhibitor containing diarylmethane structure, preparation method and use thereof |
US10584104B2 (en) | 2015-04-30 | 2020-03-10 | Tianjin Institute Of Pharmaceutical Research Co., Ltd. | Carboxylic acid URAT1 inhibitor containing diarylmethane structure, preparation method and use thereof |
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CN104262277B (zh) | 2016-06-22 |
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