CN104326997A - 烷氧基取代的三氮唑丙二酸类化合物、其制备方法及用途 - Google Patents
烷氧基取代的三氮唑丙二酸类化合物、其制备方法及用途 Download PDFInfo
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- CN104326997A CN104326997A CN201410582804.7A CN201410582804A CN104326997A CN 104326997 A CN104326997 A CN 104326997A CN 201410582804 A CN201410582804 A CN 201410582804A CN 104326997 A CN104326997 A CN 104326997A
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- 0 CC(C)*c(c1c2cccc1)ccc2-[n]1c(SC(C(O)=O)C(O)=O)nnc1C Chemical compound CC(C)*c(c1c2cccc1)ccc2-[n]1c(SC(C(O)=O)C(O)=O)nnc1C 0.000 description 2
- SLLBQYBEKGMQEW-UHFFFAOYSA-N CC(C)(C)Oc(cc1)c(cccc2)c2c1N/C(/SC(C(O)=O)C(O)=O)=N\N=C(C)C Chemical compound CC(C)(C)Oc(cc1)c(cccc2)c2c1N/C(/SC(C(O)=O)C(O)=O)=N\N=C(C)C SLLBQYBEKGMQEW-UHFFFAOYSA-N 0.000 description 1
- LBJMPAZDWXYBAE-UHFFFAOYSA-N Cc([n]1-c(c2c3cccc2)ccc3O)nnc1SC(C(O)=O)C(O)=O Chemical compound Cc([n]1-c(c2c3cccc2)ccc3O)nnc1SC(C(O)=O)C(O)=O LBJMPAZDWXYBAE-UHFFFAOYSA-N 0.000 description 1
- AMNJENVWNZEPIE-UHFFFAOYSA-N Cc([n]1-c(c2c3cccc2)ccc3OC2CC2)nnc1SC(C(O)=O)C(O)=O Chemical compound Cc([n]1-c(c2c3cccc2)ccc3OC2CC2)nnc1SC(C(O)=O)C(O)=O AMNJENVWNZEPIE-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
化合物 | IC50(hURAT1,nM) |
Lesinurad | 22.4 |
I-1 | 19.2 |
I-2 | 34.1 |
I-3 | 24.0 |
I-4 | 27.5 |
I-5 | 28.3 |
I-6 | 31.6 |
Claims (5)
Priority Applications (1)
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CN201410582804.7A CN104326997B (zh) | 2014-10-27 | 2014-10-27 | 烷氧基取代的三氮唑丙二酸类化合物、其制备方法及用途 |
Applications Claiming Priority (1)
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CN201410582804.7A CN104326997B (zh) | 2014-10-27 | 2014-10-27 | 烷氧基取代的三氮唑丙二酸类化合物、其制备方法及用途 |
Publications (2)
Publication Number | Publication Date |
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CN104326997A true CN104326997A (zh) | 2015-02-04 |
CN104326997B CN104326997B (zh) | 2016-09-21 |
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CN201410582804.7A Active CN104326997B (zh) | 2014-10-27 | 2014-10-27 | 烷氧基取代的三氮唑丙二酸类化合物、其制备方法及用途 |
Country Status (1)
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CN (1) | CN104326997B (zh) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009054792A1 (en) * | 2007-10-26 | 2009-04-30 | Astrazeneca Ab | Aminopyridine derivatives as modulators of mglur5 |
CN101684103A (zh) * | 2008-09-22 | 2010-03-31 | 天津药物研究院 | 1,2,4-三唑结构的化合物、其制备方法和用途 |
CN102186832A (zh) * | 2008-09-04 | 2011-09-14 | 亚德生化公司 | 调节尿酸含量的化合物、组合物及其使用方法 |
-
2014
- 2014-10-27 CN CN201410582804.7A patent/CN104326997B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009054792A1 (en) * | 2007-10-26 | 2009-04-30 | Astrazeneca Ab | Aminopyridine derivatives as modulators of mglur5 |
CN102186832A (zh) * | 2008-09-04 | 2011-09-14 | 亚德生化公司 | 调节尿酸含量的化合物、组合物及其使用方法 |
CN101684103A (zh) * | 2008-09-22 | 2010-03-31 | 天津药物研究院 | 1,2,4-三唑结构的化合物、其制备方法和用途 |
Also Published As
Publication number | Publication date |
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CN104326997B (zh) | 2016-09-21 |
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Effective date of registration: 20181211 Address after: 225300 Pearl River Road, Yongan Town, Taizhou, Jiangsu Province, 108 Patentee after: Wang Yajun Address before: 528000 floor 5, Pu Lan Road, Chancheng District, Foshan, Guangdong. Patentee before: Zhang Yuanqiang |
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Effective date of registration: 20191105 Address after: 314100 room 427, No.16 Fuxing Avenue, Xitang Town, Jiashan County, Jiaxing City, Zhejiang Province Patentee after: Zhejiang Xitang Industry Co., Ltd Address before: 225300 No. 108 Mingzhu Avenue, Yonganzhou Town, Gaogang District, Taizhou City, Jiangsu Province Patentee before: Wang Yajun |
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