CN104258310B - 一种治疗肝气郁结型郁证的中药 - Google Patents
一种治疗肝气郁结型郁证的中药 Download PDFInfo
- Publication number
- CN104258310B CN104258310B CN201410568115.0A CN201410568115A CN104258310B CN 104258310 B CN104258310 B CN 104258310B CN 201410568115 A CN201410568115 A CN 201410568115A CN 104258310 B CN104258310 B CN 104258310B
- Authority
- CN
- China
- Prior art keywords
- minutes
- chinese medicine
- radix
- decoction liquor
- decoction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003814 drug Substances 0.000 title claims abstract description 53
- 208000020401 Depressive disease Diseases 0.000 title claims abstract description 18
- 208000024714 major depressive disease Diseases 0.000 title claims abstract description 18
- 201000003995 melancholia Diseases 0.000 title claims abstract description 18
- 208000011580 syndromic disease Diseases 0.000 title abstract description 6
- 230000002440 hepatic effect Effects 0.000 title abstract 5
- 238000011282 treatment Methods 0.000 claims abstract description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 11
- 241000628997 Flos Species 0.000 claims description 30
- 210000004185 liver Anatomy 0.000 claims description 17
- 239000000463 material Substances 0.000 claims description 16
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 10
- 239000002994 raw material Substances 0.000 claims description 8
- 239000012467 final product Substances 0.000 claims description 7
- 238000007654 immersion Methods 0.000 claims 1
- 238000002386 leaching Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 17
- 229940079593 drug Drugs 0.000 abstract description 8
- 231100000957 no side effect Toxicity 0.000 abstract description 3
- 238000000034 method Methods 0.000 abstract description 2
- 238000009835 boiling Methods 0.000 abstract 4
- 238000001914 filtration Methods 0.000 abstract 2
- 240000000559 Albizia odoratissima Species 0.000 abstract 1
- 235000011438 Albizia odoratissima Nutrition 0.000 abstract 1
- 241000244365 Ligusticum sinense Species 0.000 abstract 1
- 244000197580 Poria cocos Species 0.000 abstract 1
- 235000008599 Poria cocos Nutrition 0.000 abstract 1
- 235000011158 Prunus mume Nutrition 0.000 abstract 1
- 244000018795 Prunus mume Species 0.000 abstract 1
- 241000220317 Rosa Species 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 201000010099 disease Diseases 0.000 description 7
- 230000008451 emotion Effects 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 206010022998 Irritability Diseases 0.000 description 4
- 210000000952 spleen Anatomy 0.000 description 4
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 3
- 239000000935 antidepressant agent Substances 0.000 description 3
- 229940005513 antidepressants Drugs 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 230000003001 depressive effect Effects 0.000 description 3
- 230000000994 depressogenic effect Effects 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 210000002216 heart Anatomy 0.000 description 3
- 206010022437 insomnia Diseases 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 230000008506 pathogenesis Effects 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000022531 anorexia Diseases 0.000 description 2
- 230000001430 anti-depressive effect Effects 0.000 description 2
- 210000000038 chest Anatomy 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 206010061428 decreased appetite Diseases 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 210000001835 viscera Anatomy 0.000 description 2
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 208000017194 Affective disease Diseases 0.000 description 1
- 208000019838 Blood disease Diseases 0.000 description 1
- 241000202726 Bupleurum Species 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010061245 Internal injury Diseases 0.000 description 1
- 208000037093 Menstruation Disturbances Diseases 0.000 description 1
- 206010027339 Menstruation irregular Diseases 0.000 description 1
- 208000019022 Mood disease Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 208000028017 Psychotic disease Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 206010040007 Sense of oppression Diseases 0.000 description 1
- 206010042458 Suicidal ideation Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 208000014951 hematologic disease Diseases 0.000 description 1
- 208000018706 hematopoietic system disease Diseases 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 208000024335 physical disease Diseases 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
- A61K36/8905—Cyperus (flatsedge)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明涉及治疗肝气郁结型郁证的中药，有效解决现有药物治疗周期长，治愈率低，效果差及有副作用的问题，由以下重量计的，合欢花6‑10g、玫瑰花6‑10g、绿萼梅6‑10g、柴胡10‑12g、白芍15‑20g、郁金15‑25g、香附10‑12g、茯神10‑15g和川芎12‑16g作原料药物制成，其中，将上述原料药物混合，加水浸没原料药物，浸泡30‑40分钟，煎煮2次，第一次煎煮时，先用武火煮沸，再用文火煎30‑40分钟，过滤，得第一次煎煮液；药渣加水浸没，武火煮沸，再用文火煎20‑30分钟，过滤，得第二次煎煮液，合并两次煎煮液，即得，本发明配伍科学，方法简单，治疗周期短，治愈率高，效果好，无副作用，是中医药上的一大创造。
Description
技术领域
本发明涉及中医药领域，特别是一种治疗肝气郁结型郁证的中药。
背景技术
郁证是由于情志不舒，气机郁滞所致，以心情抑郁，情绪不宁，胸部满闷，胁肋胀痛，或易怒易哭，或咽中如有异物梗阻等为主要临床表现的一类病症，根据受病的脏腑及气、血、火、湿、食、痰郁的不同，分为肝气郁结型等多种，其中肝气郁结型，证见情怀抑郁，胸闷嗳气，胁肋胀痛，不思饮食，易怒多梦，舌苔薄腻，脉弦，通常采用柴胡疏肝散加减或西药治疗，但是均存在治疗周期长，治愈率低，效果差、且有副作用的问题。
发明内容
针对上述情况，为克服现有技术缺陷，本发明之目的就是提供一种治疗肝气郁结型郁证的中药，可有效解决现有药物治疗周期长，治愈率低，效果差及有副作用的问题。
本发明解决的技术方案是，由以下重量计的，合欢花6-10g、玫瑰花6-10g、绿萼梅6-10g、柴胡10-12g、白芍15-20g、郁金15-25g、香附10-12g、茯神10-15g和川芎12-16g作原料药物制成，其中，将上述原料药物混合，加水浸没原料药物，浸泡30-40分钟，煎煮2次，第一次煎煮时，先用武火煮沸，再用文火煎30-40分钟，过滤，得第一次煎煮液；药渣加水浸没，武火煮沸，再用文火煎20-30分钟，过滤，得第二次煎煮液，合并两次煎煮液，即得。
要指出的是，本发明的核心和关健在于组方及配伍量，凡是采用本组方及配伍量，不管是采用什么方法制成的汤型或其它剂型，均属于本发明的保护范围，配伍科学，方法简单，治疗周期短，治愈率高，效果好，无副作用，是中医药上的一大创造。
具体实施方式
以下结合实施例对本发明的具体实施方式作详细说明。
实施例1
本发明由以下重量计的，合欢花6g、玫瑰花6g、绿萼梅6g、柴胡10g、白芍15g、郁金15g、香附10g、茯神10g和川芎12g作原料药物制成，其中，将上述原料药物混合，加水浸没原料药物，浸泡30分钟，煎煮2次，第一次煎煮时，先用武火煮沸，再用文火煎30分钟，过滤，得第一次煎煮液；药渣加水浸没，武火煮沸，再用文火煎20分钟，过滤，得第二次煎煮液，合并两次煎煮液，即得。
实施例2
本发明由以下重量计的，合欢花8g、玫瑰花8g、绿萼梅8g、柴胡11g、白芍17g、郁金20g、香附11g、茯神13g和川芎14g作原料药物制成，其中，将上述原料药物混合，加水浸没原料药物，浸泡35分钟，煎煮2次，第一次煎煮时，先用武火煮沸，再用文火煎35分钟，过滤，得第一次煎煮液；药渣加水浸没，武火煮沸，再用文火煎25分钟，过滤，得第二次煎煮液，合并两次煎煮液，即得。
实施例3
本发明由以下重量计的，合欢花10g、玫瑰花10g、绿萼梅10g、柴胡12g、白芍20g、郁金25g、香附12g、茯神15g和川芎16g作原料药物制成，其中，将上述原料药物混合，加水浸没原料药物，浸泡40分钟，煎煮2次，第一次煎煮时，先用武火煮沸，再用文火煎40分钟，过滤，得第一次煎煮液；药渣加水浸没，武火煮沸，再用文火煎30分钟，过滤，得第二次煎煮液，合并两次煎煮液，即得。
本发明是由合欢花、玫瑰花、绿萼梅、柴胡、白芍、郁金、香附、茯神和川芎制成，方中合欢花，其性平，味甘，归心、脾经，功效解郁安神，主要用于心神不安、忧郁失眠之证候；玫瑰花味甘微苦、性微温，归肝、脾、胃经，理气解郁；绿萼梅，苦、微甘，平，疏肝解郁；柴胡、郁金、香附疏肝解郁；白芍养肝敛阴，与柴胡相伍一散一收，助柴胡疏肝；川芎行气开郁，活血止痛；茯神养心安神，诸药合用，共奏疏肝解郁之功。本发明可有效用于肝气郁结型郁证的治疗，疗效肯定，并经临床应用，取得了良好的疗效，有关试验资料如下：
1、临床资料
1.1病例资料 120例郁证患者,男76例,女44例，年龄21-67岁。
1.2诊断标准 中医诊断标准：参照《中医病证诊断疗效标准》中的诊断标准。①忧郁不畅，精神不振，胸闷胁胀，善太息，或不思饮食，失眠多梦，易怒善哭; ②既往有郁怒、多虑、悲哀、忧愁等情志内伤病史; ③排除器质性疾病。
1.3 纳入标准（1）汉密尔顿抑郁量表（HAMD）17 项评分≥17 分、抑郁自评量表（SDS）评分≥53 分，病情程度属轻、中度者；（2）主动要求中医治疗，愿意受试并能坚持服药，依从性良好的患者；（3）治疗前未服用过抗抑郁西药或服用抗抑郁西药停用 3 个月以上者；（4）年龄18岁～70岁者。
1.4 排除标准（1）双向情感障碍，目前为快速循环发作或混合状态者；（2）妊娠哺乳者；（3）伴有较严重或不稳定的心、肝、肾、血液等躯体疾病者；（4）有精神病性症状的抑郁症者；（5）酒精及药物依赖者；（6）有严重自杀倾向者；（7）近 3 月服用抗抑郁药及抗精神病药物者。
2 、 治疗方案
口服本发明，每天早晚两次服用，每次服200-300ml，28天1疗程。1疗程后观察疗效。
3 、 观察指标与统计学方法
3.1观察指标
3.1.1临床症状观察治疗前后患者抑郁善忧，情绪不宁，遇事淡漠，心烦易怒，善哭，胁肋胀痛，失眠多梦，女性月经不调等变化。
3.1.2 HAMD评分 观察治疗前后患者汉密尔顿抑郁量表（HAMD）17 项评分变化。
3.2 疗效标准
3.2.1 疗效判定 参照《中医病证诊断疗效标准》。
痊愈:症状消失，情绪正常。
显效: 症状减轻，情绪基本稳定。
无效: 症状、情绪均无改善。
3.3 统计学方法 数据采用SPSS13.0 软件包进行处理，计量数据均以（x±s）表示，进行 t 检验，计数资料采用百分比表示，采用χ2检验，P<0.05 为有显著性差异。
4 、 治疗结果
4.1 临床疗效患者120例，痊愈49例（占40.8%），显效62例（占51.7%），无效9 例（占7.5%），总有效率 92.5%。且在治疗期间，以上120例患者均未见有任何不良反应。
4.2治疗前后HAMD 评分比较（x±s），见表1
表1，治疗前后HAMD 评分比较
| 组别 | 治疗前 | 治疗后 |
| 本发明中药 | 18.98±2.12 | 9.14±5.43 |
注：与治疗前比较，*P<0.05。
从表1可见，治疗组治疗后HAMD 评分较治疗前明显降低，经t 检验P<0.05，有显著性差异。说明本方疗效显著。
5 、 结论
5.1病因病机与治则：本发明结合历代医家论述和临床经验，认为郁证是以情志不舒为病因，以气机郁滞为基本病机，病位在脑，与心、肝、脾三脏密切相关；因郁怒、思虑、悲伤、忧愁所伤，导致肝失疏泄，脾失运化，心神失常，脏腑阴阳气血失调而成。肝气郁结型是郁证的主要病机，治疗当以疏肝解郁为主。本发明通过对120例患者的临床治疗，疗效显著，治疗周期短，治愈率高，仅在28天1疗程，痊愈率可达40.8%，总有效率就达到了92.5%，效果好，无副作用，而现有治疗肝气郁结型郁证的中药至少要服用3-6个月，甚至更长的时间，方能达到本发明28天1疗程的效果，由此可见，本发明具有显著的经济和社会效益。
Claims (4)
1.一种治疗肝气郁结型郁证的中药，其特征在于，由以下重量计的，合欢花6-10g、玫瑰花6-10g、绿萼梅6-10g、柴胡10-12g、白芍15-20g、郁金15-25g、香附10-12g、茯神10-15g和川芎12-16g作原料药物制成，其中，将上述原料药物混合，加水浸没原料药物，浸泡30-40分钟，煎煮2次，第一次煎煮时，先用武火煮沸，再用文火煎30-40分钟，过滤，得第一次煎煮液；药渣加水浸没，武火煮沸，再用文火煎20-30分钟，过滤，得第二次煎煮液，合并两次煎煮液。
2.根据权利要求1所述的治疗肝气郁结型郁证的中药，其特征在于，由以下重量计的，合欢花6g、玫瑰花6g、绿萼梅6g、柴胡10g、白芍15g、郁金15g、香附10g、茯神10g和川芎12g作原料药物制成，其中，将上述原料药物混合，加水浸没原料药物，浸泡30分钟，煎煮2次，第一次煎煮时，先用武火煮沸，再用文火煎30分钟，过滤，得第一次煎煮液；药渣加水浸没，武火煮沸，再用文火煎20分钟，过滤，得第二次煎煮液，合并两次煎煮液，即得。
3.根据权利要求1所述的治疗肝气郁结型郁证的中药，其特征在于，由以下重量计的，合欢花8g、玫瑰花8g、绿萼梅8g、柴胡11g、白芍17g、郁金20g、香附11g、茯神13g和川芎14g作原料药物制成，其中，将上述原料药物混合，加水浸没原料药物，浸泡35分钟，煎煮2次，第一次煎煮时，先用武火煮沸，再用文火煎35分钟，过滤，得第一次煎煮液；药渣加水浸没，武火煮沸，再用文火煎25分钟，过滤，得第二次煎煮液，合并两次煎煮液，即得。
4.根据权利要求1所述的治疗肝气郁结型郁证的中药，其特征在于，由以下重量计的，合欢花10g、玫瑰花10g、绿萼梅10g、柴胡12g、白芍20g、郁金25g、香附12g、茯神15g和川芎16g作原料药物制成，其中，将上述原料药物混合，加水浸没原料药物，浸泡40分钟，煎煮2次，第一次煎煮时，先用武火煮沸，再用文火煎40分钟，过滤，得第一次煎煮液；药渣加水浸没，武火煮沸，再用文火煎30分钟，过滤，得第二次煎煮液，合并两次煎煮液，即得。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410568115.0A CN104258310B (zh) | 2014-10-23 | 2014-10-23 | 一种治疗肝气郁结型郁证的中药 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410568115.0A CN104258310B (zh) | 2014-10-23 | 2014-10-23 | 一种治疗肝气郁结型郁证的中药 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104258310A CN104258310A (zh) | 2015-01-07 |
| CN104258310B true CN104258310B (zh) | 2017-05-03 |
Family
ID=52149967
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410568115.0A Expired - Fee Related CN104258310B (zh) | 2014-10-23 | 2014-10-23 | 一种治疗肝气郁结型郁证的中药 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104258310B (zh) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105796945A (zh) * | 2016-03-16 | 2016-07-27 | 曲思廉 | 一种治疗郁证的中药 |
| CN105878941A (zh) * | 2016-06-07 | 2016-08-24 | 华北理工大学 | 一种治疗抑郁症的中药丸剂及其制备方法 |
| CN105902929A (zh) * | 2016-06-28 | 2016-08-31 | 唐冬香 | 一种治疗肝气郁结的中药 |
| CN106267037A (zh) * | 2016-11-11 | 2017-01-04 | 东莞市百替生物科技有限公司 | 一种治疗肝气郁结证的中药组合物及制备方法 |
| CN106901278A (zh) * | 2017-02-28 | 2017-06-30 | 浦北县龙腾食品有限公司 | 具有抗疲劳功效的土豆丸的制备方法 |
| CN106912851A (zh) * | 2017-02-28 | 2017-07-04 | 浦北县龙腾食品有限公司 | 土豆丸的加工方法 |
| CN108096370A (zh) * | 2018-01-18 | 2018-06-01 | 河南中医药大学 | 一种治疗湿疹的中药 |
| CN112089782B (zh) * | 2020-09-22 | 2021-11-23 | 上海市静安区中医医院 | 一种解郁中药药枕及其应用 |
| CN113521185B (zh) * | 2021-08-03 | 2022-08-26 | 河南中医药大学 | 一种舒缓情绪的中药香囊、制备方法和应用 |
| CN115581259A (zh) * | 2022-10-10 | 2023-01-10 | 黑龙江中医药大学 | 一种具有解郁功效的玫瑰花茶茶包及其制备方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101147773A (zh) * | 2006-09-19 | 2008-03-26 | 于振鹏 | 治疗神经衰弱的药 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4799434B2 (ja) * | 2007-01-31 | 2011-10-26 | イスクラ産業株式会社 | 向精神剤 |
-
2014
- 2014-10-23 CN CN201410568115.0A patent/CN104258310B/zh not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101147773A (zh) * | 2006-09-19 | 2008-03-26 | 于振鹏 | 治疗神经衰弱的药 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104258310A (zh) | 2015-01-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104258310B (zh) | 一种治疗肝气郁结型郁证的中药 | |
| CN108771707A (zh) | 一种用于足底贴敷防治偏头痛的组合物以及使用方法 | |
| CN103417716B (zh) | 一种治疗糖尿病周围神经病变的降糖通络片 | |
| CN104689218A (zh) | 一种治疗脂肪肝的中药组合物 | |
| CN101411798A (zh) | 一种治疗精神分裂症的中药制剂 | |
| CN104288255A (zh) | 治疗重症急性胰腺炎的中药制剂 | |
| CN107714760A (zh) | 一种用于治疗急性乳腺炎的中药配方及制备方法 | |
| CN106668488A (zh) | 一种治疗失眠的药物及其制备方法 | |
| CN103463593A (zh) | 一种治疗肥胖症的药茶 | |
| CN103798472B (zh) | 一种保健茶及保健养生制剂 | |
| CN104771699A (zh) | 一种治疗儿童抽动障碍的药物及其制备方法 | |
| CN104489470A (zh) | 一种治疗肾虚的中药粥及制作方法 | |
| CN103948880B (zh) | 一种治疗心律失常的中药 | |
| CN103463340A (zh) | 一种治疗偏头痛的中药制剂 | |
| CN104740579B (zh) | 经前安片及其制备工艺 | |
| CN107982471A (zh) | 一种小儿健脾开胃中药泡澡剂及其制备方法 | |
| CN103055172A (zh) | 一种治疗白癜风的中药组合 | |
| CN105663416A (zh) | 一种治疗心血瘀阻型胸痹的中药组合物及其制备方法 | |
| CN102784376B (zh) | 一种治疗纳呆型急性肾小球肾炎的中药制备方法 | |
| CN106581612A (zh) | 一种治疗肺源性心脏病的中药配方 | |
| CN106729521A (zh) | 一种治疗中风的中药配方及其制备方法 | |
| CN106619866A (zh) | 一种润肠通便的中药养生汤 | |
| CN106110121A (zh) | 一种治疗花斑癣的中药组合物 | |
| CN105396108A (zh) | 一种治疗风寒感冒的足浴疗养中药 | |
| CN105687581A (zh) | 一种治疗湿热阻胃型痞满的中药组合物及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170503 Termination date: 20181023 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |