CN104258293A - 一种治疗风湿性舞蹈病的中药及其制备方法 - Google Patents
一种治疗风湿性舞蹈病的中药及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗风湿性舞蹈病的中药,它是由以下药材制备成:桂枝15份、白芍20份、生地18份、麦冬12份、生石决明10份、钩藤12份、八角枫12份、僵蚕12份、八角金盘12份、薏苡仁30份、苍术15份、牛膝10份、川芎12份、独活12份、秦艽15份、威灵仙15份、木瓜15份、生龙骨24份、生牡蛎20份、阿胶9份、麻仁12份、生龟板15份、丹参20份、赤芍12份、半枫荷10份、宝盖草12份、白乳菇10份、紫茎12份、白柳12份、白花蛇10份、浮小麦50份、大枣12枚、郁金18份、天麻15份、防风12份、茯苓15份、甘草12份。临床实验证明,本发明能够安全有效的治疗风湿性舞蹈病。
Description
技术领域
本发明涉及一种中药领域,特别是一种治疗风湿性舞蹈病的中药及其制备方法。
背景技术
风湿性舞蹈病,多见于5~15岁女童,表现为不自主、无规律的急速舞蹈动作,肌张力降低和精神障碍。青春期后发病率迅速下降,偶有成年妇女发病,主要为孕妇。脑炎、白喉、水痘、麻疹、百日咳等感染以及系统性红斑狼疮和一氧化碳中毒等偶可引起本病。
主要临床表现:早期为注意力分散、学习成绩下降、动作笨拙、坐立不安、持物易落地、四肢远端及面部轻微不自主运动等。进而发展可以是全身性,也可以是一侧较重,主要累及面部和肢体远端。表现为挤眉、弄眼、撅嘴、吐舌、扮鬼脸,上肢各关节交替伸屈、内收,下肢步态颠簸,精神紧张时加重,睡眠时消失。患儿可能会用有意识地主动运动去掩盖不自主运动。不自主舞蹈样动作可干扰随意运动,导致步态笨拙、持物跌落、动作不稳、暴发性言语。舞蹈症常在发病2~4周内加重,3~6个月内自发缓解。约20%的患儿会复发,通常在2年内。少数在初次发病10年后再次出现轻微的舞蹈症。可有明显的肌张力减低和肌无力。当患儿举臂过头时,手掌旋前(旋前肌征)。检查者请患儿紧握检查者的第二、三手指时能感到患儿手的紧握程度不恒定,时紧时松,称为挤奶妇手法或盈亏征。有时肌无力可以是本病的突出征象,以致患儿在急性期不得不卧床。患儿常伴某些精神症状,如焦虑、抑郁、情绪不稳、激惹、注意力下降、偏执-强迫行为等。有时精神症状先于舞蹈症出现。约1/3患儿可伴其他急性风湿热表现,如低热、关节炎、心瓣膜炎、风湿结节等。目前,用于治疗风湿性舞蹈病的药物较多,多以西药为主,存在治疗效果较差、治疗时间长、副作用大等不足。
发明内容
本发明要解决的问题是:提供一种治疗风湿性舞蹈病的中药,通过选择合适的药材及其配比,达到安全有效治愈风湿性舞蹈病的目的。
为了解决上述技术问题,本发明采用以下技术方案:
一种治疗风湿性舞蹈病的中药,其特征在于,它是由以下重量份数配比的药材制备成:桂枝12-18份、白芍18-22份、生地15-20份、麦冬10-15份、生石决明8-12份、钩藤10-15份、八角枫10-15份、僵蚕10-15份、八角金盘10-15份、薏苡仁25-35份、苍术12-18份、牛膝8-12份、川芎10-15份、独活10-15份、秦艽12-18份、威灵仙12-18份、木瓜12-18份、生龙骨22-25份、生牡蛎18-22份、阿胶8-10份、麻仁10-15份、生龟板12-18份、丹参18-22份、赤芍10-15份、半枫荷8-12份、宝盖草10-15份、白乳菇8-12份、紫茎10-15份、白柳10-15份、白花蛇8-12份、浮小麦40-60份、大枣10-15枚、郁金15-20份、天麻12-18份、防风10-15份、茯苓12-18份、甘草10-15份。
所述治疗风湿性舞蹈病的中药,其特征在于,它是由以下重量份数配比的药材制备成:桂枝15份、白芍20份、生地18份、麦冬12份、生石决明10份、钩藤12份、八角枫12份、僵蚕12份、八角金盘12份、薏苡仁30份、苍术15份、牛膝10份、川芎12份、独活12份、秦艽15份、威灵仙15份、木瓜15份、生龙骨24份、生牡蛎20份、阿胶9份、麻仁12份、生龟板15份、丹参20份、赤芍12份、半枫荷10份、宝盖草12份、白乳菇10份、紫茎12份、白柳12份、白花蛇10份、浮小麦50份、大枣12枚、郁金18份、天麻15份、防风12份、茯苓15份、甘草12份。
所述的治疗风湿性舞蹈病的中药的制备方法是:由所述中药按常规方法制成汤剂、胶囊剂、散剂或颗粒剂。
用法及用量:本发明的中药以汤剂为主,每日1付,分2次服用,早、晚各服用1次,15天为1个疗程,一般2-5个疗程即可治愈;也可将其制成胶囊剂、散剂或颗粒剂。
本发明与现有技术相比所具有的有益效果是:本发明是在传统中医理论和临床经验指导下,精选出各原料药及其配比,具有补血、养血、活血、养心安神、清热泻火、熄风宁神、舒筋止挛的功效,实现治疗风湿性舞蹈病的目的;本发明具有疗效显著、见效快、无毒副作用、制备方法简单等优点,经临床验证,本发明治疗风湿性舞蹈病有效率90%。
具体实施方式
为了更好地理解和实施本发明,下面结合具体实施例进一步说明本发明。
具体实施例1
1)、汤剂的制备方法:第一步称取阿胶9克打碎,粉碎成阿胶粉,分成两份备用;第二步称取桂枝15克、白芍20克、生地18克、麦冬12克、生石决明10克、钩藤12克、八角枫12克、僵蚕12克、八角金盘12克、薏苡仁30克、苍术15克、牛膝10克、川芎12克、独活12克、秦艽15克、威灵仙15克、木瓜15克、生龙骨24克、生牡蛎20克、麻仁12克、生龟板15克、丹参20克、赤芍12克、半枫荷10克、宝盖草12克、白乳菇10克、紫茎12克、白柳12克、白花蛇10克、浮小麦50克、大枣12枚、郁金18克、天麻15克、防风12克、茯苓15克、甘草12克。用传统的煎药方法,把药物放入药锅中加入适量的水浸泡1小时,用武火煮沸以后再用中火煮20-30分钟,把药汁倒出,再放适量的水用武火煮沸后中火煎煮15-20分,倒出药汁,2次药汁混合后分2份;第三步服用前,用第二步中的中药汁烊化第一步中的阿胶粉,早晚各一次服用。
2)、胶囊剂的制备方法:第一步称取阿胶9克打碎,粉碎成阿胶粉;第二步称取桂枝15克、白芍20克、生地18克、麦冬12克、生石决明10克、钩藤12克、八角枫12克、僵蚕12克、八角金盘12克、薏苡仁30克、苍术15克、牛膝10克、川芎12克、独活12克、秦艽15克、威灵仙15克、木瓜15克、生龙骨24克、生牡蛎20克、麻仁12克、生龟板15克、丹参20克、赤芍12克、半枫荷10克、宝盖草12克、白乳菇10克、紫茎12克、白柳12克、白花蛇10克、浮小麦50克、大枣12枚、郁金18克、天麻15克、防风12克、茯苓15克、甘草12克。把药物放入药锅中加10倍量水,煎煮1小时,过滤;滤渣加8倍量水,煎煮1小时,过滤;合并滤液,浓缩,干燥成中药粉;第三步将第一步中的阿胶粉和第二步中的中药粉混合均匀,装入空胶囊中,即得符合正常成人一天用量的胶囊剂。
用于治疗风湿性舞蹈病。口服,每日分早晚两次服用。
3)、散剂的制备方法:第一步称取阿胶9克打碎,粉碎成阿胶粉;第二步称取桂枝15克、白芍20克、生地18克、麦冬12克、生石决明10克、钩藤12克、八角枫12克、僵蚕12克、八角金盘12克、薏苡仁30克、苍术15克、牛膝10克、川芎12克、独活12克、秦艽15克、威灵仙15克、木瓜15克、生龙骨24克、生牡蛎20克、麻仁12克、生龟板15克、丹参20克、赤芍12克、半枫荷10克、宝盖草12克、白乳菇10克、紫茎12克、白柳12克、白花蛇10克、浮小麦50克、大枣12枚、郁金18克、天麻15克、防风12克、茯苓15克、甘草12克。把药物放入药锅中加12倍量水,煎煮2小时,过滤;滤渣加10倍量水,煎煮1.5小时,过滤;合并滤液,浓缩,干燥成中药粉;第三步将第一步中的阿胶粉和第二步中的中药粉混合均匀,包装,即得符合正常成人一天用量的散剂。
用于治疗风湿性舞蹈病。口服,每日分早晚两次服用。
4)、颗粒剂的制备方法:第一步称取阿胶9克打碎,粉碎成阿胶粉;第二步称取桂枝15克、白芍20克、生地18克、麦冬12克、生石决明10克、钩藤12克、八角枫12克、僵蚕12克、八角金盘12克、薏苡仁30克、苍术15克、牛膝10克、川芎12克、独活12克、秦艽15克、威灵仙15克、木瓜15克、生龙骨24克、生牡蛎20克、麻仁12克、生龟板15克、丹参20克、赤芍12克、半枫荷10克、宝盖草12克、白乳菇10克、紫茎12克、白柳12克、白花蛇10克、浮小麦50克、大枣12枚、郁金18克、天麻15克、防风12克、茯苓15克、甘草12克。把药物放入药锅中加8倍量水,煎煮2小时,过滤;滤渣加6倍量水,煎煮1.5小时,过滤;合并滤液,浓缩,干燥成中药粉;第三步将第一步中的阿胶粉和第二步中的中药粉混合均匀,再加入适量的糊精和矫味剂,按照本领域常规工艺制粒,包装,即得符合正常成人一天用量的颗粒剂。
用于治疗风湿性舞蹈病。口服,每日分早晚两次服用。
具体实施例2
称取桂枝12克、白芍18克、生地15克、麦冬10克、生石决明8克、钩藤10克、八角枫10克、僵蚕10克、八角金盘10克、薏苡仁25克、苍术12克、牛膝8克、川芎10克、独活10克、秦艽12克、威灵仙12克、木瓜12克、生龙骨22克、生牡蛎18克、阿胶(烊化冲服)8克、麻仁10克、生龟板12克、丹参18克、赤芍10克、半枫荷8克、宝盖草10克、白乳菇8克、紫茎10克、白柳10克、白花蛇8克、浮小麦40克、大枣10枚、郁金15克、天麻12克、防风10克、茯苓12克、甘草10克。按照实施例1的方法制备成汤剂、胶囊剂、散剂或颗粒剂。
具体实施例3
称取桂枝18克、白芍22克、生地20克、麦冬15克、生石决明12克、钩藤15克、八角枫15克、僵蚕15克、八角金盘15克、薏苡仁35克、苍术18克、牛膝12克、川芎15克、独活15克、秦艽18克、威灵仙18克、木瓜18克、生龙骨25克、生牡蛎22克、阿胶(烊化冲服)10克、麻仁15克、生龟板18克、丹参22克、赤芍15克、半枫荷12克、宝盖草15克、白乳菇12克、紫茎15克、白柳15克、白花蛇12克、浮小麦60克、大枣15枚、郁金20克、天麻18克、防风15克、茯苓18克、甘草15克。按照实施例1的方法制备成汤剂、胶囊剂、散剂或颗粒剂。
实验例:
1)临床资料:本发明共治疗风湿性舞蹈病患者30例,其中男16例,女14例,年龄为12-22岁。
2)治疗方法:本发明的中药以汤剂为主,每日1付,分2次服用,早、晚各服用1次,15天为1个疗程,一般2-5个疗程即可治愈;也可将其制成胶囊剂、散剂或颗粒剂。
3)疗效评价标准:
治愈:症状消失,实验室检查正常;
好转:症状明显改善,实验室检查有改善;
未愈:主症未改善,实验室检查未改善。
4)治疗结果:本发明共治疗风湿性舞蹈病患者30例,经过2-5个疗程的治疗,治愈21例,占70%,好转6例,占20%,未愈3例,占10%,有效率为90%。
5)典型病例:
1、宋某,男,12岁,3年前患风湿性舞蹈病,多方求医无效,早期表现为不自主、无规律的急速舞蹈动作,注意力分散、学习成绩下降、动作笨拙、坐立不安、持物易落地、四肢远端及面部轻微不自主运动等。进而发展表现为挤眉、弄眼、撅嘴、吐舌、扮鬼脸,上肢各关节交替伸屈、内收,下肢步态颠簸,精神紧张时加重,睡眠时消失。服用本发明的中药2个疗程后好转,服用5个疗程治愈,随访至今未复发。
2、魏某某,女,22岁,10年前患风湿性舞蹈病,治愈后又复发,服用本发明的中药2个疗程后好转,服用5个疗程治愈,3年未复发。
3、孟某,男,15岁,13岁患风湿性舞蹈病,多方求医无效。经人介绍服用本发明的中药1个疗程后好转,服用3个疗程治愈,随访至今未复发。
4、吕某,男,18岁,患风湿性舞蹈病5年,服用本发明的中药3个疗程后好转,服用5个疗程治愈,随访至今未复发。
经过大量的临床医疗实践证明,本发明治疗风湿性舞蹈病的中药,属于纯中药制剂,对人体毒、副作用小,对治疗风湿性舞蹈病具有可靠、安全、显著的治疗效果。
Claims (3)
1.一种治疗风湿性舞蹈病的中药,其特征在于,它是由以下重量份数配比的药材制备成:桂枝12-18份、白芍18-22份、生地15-20份、麦冬10-15份、生石决明8-12份、钩藤10-15份、八角枫10-15份、僵蚕10-15份、八角金盘10-15份、薏苡仁25-35份、苍术12-18份、牛膝8-12份、川芎10-15份、独活10-15份、秦艽12-18份、威灵仙12-18份、木瓜12-18份、生龙骨22-25份、生牡蛎18-22份、阿胶8-10份、麻仁10-15份、生龟板12-18份、丹参18-22份、赤芍10-15份、半枫荷8-12份、宝盖草10-15份、白乳菇8-12份、紫茎10-15份、白柳10-15份、白花蛇8-12份、浮小麦40-60份、大枣10-15枚、郁金15-20份、天麻12-18份、防风10-15份、茯苓12-18份、甘草10-15份。
2.根据权利要求1所述的治疗风湿性舞蹈病的中药,其特征在于,它是由以下重量份数配比的药材制备成:桂枝15份、白芍20份、生地18份、麦冬12份、生石决明10份、钩藤12份、八角枫12份、僵蚕12份、八角金盘12份、薏苡仁30份、苍术15份、牛膝10份、川芎12份、独活12份、秦艽15份、威灵仙15份、木瓜15份、生龙骨24份、生牡蛎20份、阿胶9份、麻仁12份、生龟板15份、丹参20份、赤芍12份、半枫荷10份、宝盖草12份、白乳菇10份、紫茎12份、白柳12份、白花蛇10份、浮小麦50份、大枣12枚、郁金18份、天麻15份、防风12份、茯苓15份、甘草12份。
3.一种治疗风湿性舞蹈病的中药的制备方法,其特征在于,由权利要求1或2所述的治疗风湿性舞蹈病的中药按常规方法制成汤剂、胶囊剂、散剂或颗粒剂。
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