CN104258103B - A kind of stem of noble dendrobium buccal tablet and preparation method - Google Patents
A kind of stem of noble dendrobium buccal tablet and preparation method Download PDFInfo
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- CN104258103B CN104258103B CN201410510019.0A CN201410510019A CN104258103B CN 104258103 B CN104258103 B CN 104258103B CN 201410510019 A CN201410510019 A CN 201410510019A CN 104258103 B CN104258103 B CN 104258103B
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- stem
- parts
- noble dendrobium
- buccal tablet
- powder
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- 240000004638 Dendrobium nobile Species 0.000 title claims abstract description 128
- 239000006189 buccal tablet Substances 0.000 title claims abstract description 53
- 229940046011 buccal tablet Drugs 0.000 title claims abstract description 53
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 239000000843 powder Substances 0.000 claims abstract description 72
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 39
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 31
- 238000012216 screening Methods 0.000 claims abstract description 26
- 244000025254 Cannabis sativa Species 0.000 claims abstract description 22
- 244000246386 Mentha pulegium Species 0.000 claims abstract description 22
- 235000016257 Mentha pulegium Nutrition 0.000 claims abstract description 22
- 235000004357 Mentha x piperita Nutrition 0.000 claims abstract description 22
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 22
- 235000001050 hortel pimenta Nutrition 0.000 claims abstract description 22
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 22
- 239000000741 silica gel Substances 0.000 claims abstract description 22
- 229910002027 silica gel Inorganic materials 0.000 claims abstract description 22
- 229920002472 Starch Polymers 0.000 claims abstract description 19
- 229930006000 Sucrose Natural products 0.000 claims abstract description 19
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 19
- 235000019698 starch Nutrition 0.000 claims abstract description 19
- 239000008107 starch Substances 0.000 claims abstract description 19
- 239000000463 material Substances 0.000 claims abstract description 16
- 239000002245 particle Substances 0.000 claims abstract description 16
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract 4
- 239000000203 mixture Substances 0.000 claims description 38
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- 241000196324 Embryophyta Species 0.000 claims description 15
- 238000001035 drying Methods 0.000 claims description 13
- 230000014759 maintenance of location Effects 0.000 claims description 13
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 10
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 claims description 10
- 108091005804 Peptidases Proteins 0.000 claims description 8
- 239000004365 Protease Substances 0.000 claims description 8
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims description 8
- 238000009413 insulation Methods 0.000 claims description 7
- 238000002203 pretreatment Methods 0.000 claims description 7
- 108010084185 Cellulases Proteins 0.000 claims description 6
- 102000005575 Cellulases Human genes 0.000 claims description 6
- 108010002430 hemicellulase Proteins 0.000 claims description 6
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 5
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 5
- 229930003268 Vitamin C Natural products 0.000 claims description 5
- 235000010265 sodium sulphite Nutrition 0.000 claims description 5
- 235000019154 vitamin C Nutrition 0.000 claims description 5
- 239000011718 vitamin C Substances 0.000 claims description 5
- 235000005979 Citrus limon Nutrition 0.000 claims 1
- 244000131522 Citrus pyriformis Species 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 235000009508 confectionery Nutrition 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract description 19
- 229930195725 Mannitol Natural products 0.000 abstract description 19
- 239000000594 mannitol Substances 0.000 abstract description 19
- 235000010355 mannitol Nutrition 0.000 abstract description 19
- 102000004190 Enzymes Human genes 0.000 abstract description 10
- 108090000790 Enzymes Proteins 0.000 abstract description 10
- 241001570521 Lonicera periclymenum Species 0.000 description 16
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 12
- 229940088598 enzyme Drugs 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 241001523681 Dendrobium Species 0.000 description 8
- 238000002156 mixing Methods 0.000 description 8
- 238000000227 grinding Methods 0.000 description 5
- 230000003534 oscillatory effect Effects 0.000 description 5
- 150000004676 glycans Chemical class 0.000 description 4
- 230000000050 nutritive effect Effects 0.000 description 4
- 229920001282 polysaccharide Polymers 0.000 description 4
- 239000005017 polysaccharide Substances 0.000 description 4
- RYAHJFGVOCZDEI-UFFNCVEVSA-N Dendrobine Chemical compound C([C@H]1CC[C@@H]2[C@@]31C)N(C)[C@@H]3[C@H]1[C@@H](C(C)C)[C@@H]2C(=O)O1 RYAHJFGVOCZDEI-UFFNCVEVSA-N 0.000 description 3
- RYAHJFGVOCZDEI-CZKZLRAZSA-N dendrobine Natural products O=C1O[C@@H]2[C@H](C(C)C)[C@H]1[C@H]1[C@@]3(C)[C@@H]2N(C)C[C@H]3CC1 RYAHJFGVOCZDEI-CZKZLRAZSA-N 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 230000007613 environmental effect Effects 0.000 description 3
- 238000011049 filling Methods 0.000 description 3
- 239000007937 lozenge Substances 0.000 description 3
- 210000000214 mouth Anatomy 0.000 description 3
- 230000001953 sensory effect Effects 0.000 description 3
- 238000005728 strengthening Methods 0.000 description 3
- 108010059892 Cellulase Proteins 0.000 description 2
- 241000245240 Lonicera Species 0.000 description 2
- 241000233855 Orchidaceae Species 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 229940106157 cellulase Drugs 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- CPJSUEIXXCENMM-UHFFFAOYSA-N phenacetin Chemical compound CCOC1=CC=C(NC(C)=O)C=C1 CPJSUEIXXCENMM-UHFFFAOYSA-N 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- 241000026010 Dendrobium candidum Species 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 229920002488 Hemicellulose Polymers 0.000 description 1
- 241001237160 Kallima inachus Species 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- MWKXCSMICWVRGW-UHFFFAOYSA-N calcium;phosphane Chemical compound P.[Ca] MWKXCSMICWVRGW-UHFFFAOYSA-N 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000007891 compressed tablet Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 235000012149 noodles Nutrition 0.000 description 1
- 235000008935 nutritious Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229960003893 phenacetin Drugs 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 210000000697 sensory organ Anatomy 0.000 description 1
- 230000014860 sensory perception of taste Effects 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of stem of noble dendrobium buccal tablet, include the component of following parts by weight:58 parts of 350 400 parts of dendrobe ultrafine powder, 240 360 parts of white sugar powder, 260 320 parts of mannitol, 50 80 parts of soluble starch, 30 70 parts of honeysuckle, 25 parts of peppermint grass, 35 parts of magnesium stearate and superfine silica gel powder.The invention also discloses a kind of preparation method of stem of noble dendrobium buccal tablet, comprise the following steps:The 5h of complex enzyme zymohydrolysis 3 will be utilized after the fresh material disintegrating of the stem of noble dendrobium, freeze 16 48h under the conditions of 45 50 DEG C afterwards, then crush as Ultramicro-powder;By dendrobe ultrafine powder, 350 400 parts are well mixed with other components, cross 75 mesh sieves and obtain screenings, mixed with mass percentage concentration ratio for 42% 45% ethanol solutions, cross 16 24 mesh sieves and obtain screenings, dry stem of noble dendrobium particle, stem of noble dendrobium particle and magnesium stearate and superfine silica gel powder are mixed and obtain stem of noble dendrobium buccal tablet after carrying out tabletting.
Description
Technical field
The present invention relates to a kind of stem of noble dendrobium buccal tablet and preparation method.
Background technology
One of the stem of noble dendrobium, orchid, as valuable medicinal material, it is distributed mainly on Tropical Asian and subtropical zone.In China, greatly
Part is distributed in the ground such as southwest, south China, Taiwan.Early in《Sheng Nong's herbal classic》In just it is on the books, be listed as top grade.《Compendium of Materia Medica》
Record, custom side most with qi-restoratives, is cured mainly in wound, and gas under eliminating impediment, tonifying five zang organs consumptive disease is thin thin, once shady strengthening the essence, thick stomach, in benefit never
Foot.As medicinal material or food materials, its source is mostly the fresh or drying of orchid family herbaceos perennial HERBA DENDROBII and dendrobium candidum
Stem, the stem of noble dendrobium have reinforcing stomach reg fluid, drive the curative effects such as solution abnormal heat, the strong the moon of strengthening the essence.Contain substantial amounts of dendrobine and polysaccharide slime formers in the stem of noble dendrobium
Matter, wherein, dendrobine has certain analgesic antipyretic effect, and similar but weaker to phenacetin, dendrobium polysaccharide can strengthen body and exempt from
Epidemic disease function, and there is anti-tumor function.
Traditional stem of noble dendrobium manufacture craft, technique be present and simply take, and easily cause the forfeiture of dendrobium nutrient composition.It is existing
The present, stem of noble dendrobium research worker have developed many from point food being worth using dendrobium nutrient, such as number of patent application
201110293104.2 " a kind of dendrobium nobile nutritive powders ", application number 201310462318.7 " a kind of preparation method of dendrobium stem beverage ",
Application number 201310387476.0 " a kind of preparation method of purple dendrobium noodles ".
Buccal tablet refers to the compressed tablets for being contained in slow mechanism dissolved in oral cavity, in addition to the good basic demand of the solubility except meeting tablet,
Must also possess tempting color, the mouthfeel for having had user.The key issue of stem of noble dendrobium lozenge is coarse not slide at present
It is greasy, it is not satiny to feel to be due to that each dissolution velocity is inconsistent and cause the contact surface of tablet and tongue trickle friction occur in composition
Caused by, therefore, buccal tablet will not only consider dissolution rate problem, also solve sensory issues.
The content of the invention
An object of the present invention is to provide a kind of stem of noble dendrobium buccal tablet, and each ingredient granules are thin in stem of noble dendrobium buccal tablet of the invention
It is greasy and be mixed with each other uniformly, solve sensory issues;
It is a further object of the present invention to provide a kind of preparation method of stem of noble dendrobium buccal tablet, method of the invention utilizes complex enzyme
Dissolve the carbohydrate and the composition such as albumen of stem of noble dendrobium cell surface, discharge active ingredient in the stem of noble dendrobium, solve the stem of noble dendrobium effectively into
The dissolution problem divided, while the method for the present invention is provided with color retention, the sensory issues for solving stem of noble dendrobium lozenge, keep
The color of stem of noble dendrobium raw material.
Technical scheme provided by the invention is:
A kind of stem of noble dendrobium buccal tablet, include the component of following parts by weight:
Dendrobe ultrafine powder 350-400 parts, white sugar powder 240-360 parts, mannitol 260-320 parts and soluble starch 50-
80 parts.
Preferably, described stem of noble dendrobium buccal tablet, the component of following parts by weight is included:
2~5 parts of honeysuckle 30-70 parts and peppermint grass.
Preferably, described stem of noble dendrobium buccal tablet, the component of following parts by weight is included:Magnesium stearate 3-5 parts and micro-
Powder silica gel 5-8 parts.
Preferably, in described stem of noble dendrobium buccal tablet, the stem of noble dendrobium buccal tablet includes the component of following parts by weight:
380 parts of dendrobe ultrafine powder, 360 parts of white sugar powder, 320 parts of mannitol, 65 parts of soluble starch, 4 parts of magnesium stearate
With 6 parts of superfine silica gel powder.
Preferably, in described stem of noble dendrobium buccal tablet, the stem of noble dendrobium buccal tablet is made up of the component of following parts by weight:
380 parts of dendrobe ultrafine powder, 360 parts of white sugar powder, 320 parts of mannitol, 65 parts of soluble starch, 50 parts of honeysuckle,
6 parts of 3 parts of peppermint grass, 4 parts of magnesium stearate and superfine silica gel powder.
A kind of preparation method of stem of noble dendrobium buccal tablet, including:
Step 1: obtaining screenings by 10 mesh sieves are crossed after the fresh material disintegrating of the stem of noble dendrobium, the U/Kg celluloses of 50-90 ten thousand are added afterwards
Enzyme, 1500-2000U/Kg hemicellulases and the U/Kg protease of 20-25 ten thousand, add and account for the fresh material weight 0.6-1.5 of the stem of noble dendrobium
It is that insulation digests 3-5h at 35-42 DEG C of 85%-95% and temperature in ambient humidity after water again mixes;
Step 2: the stem of noble dendrobium after enzymolysis is freezed into 16-48h under the conditions of -45--50 DEG C, it is Ultramicro-powder to crush afterwards;
Step 3: the component of following parts by weight is mixed:Dendrobe ultrafine powder 350-400 parts, white sugar powder 240-360
Part, mannitol 260-320 parts and soluble starch 50-80 parts, cross 75 mesh sieves by mixture afterwards and obtain screenings;
Step 4:The mixture obtained in step 3 and mass percentage concentration ratio are mixed for 42%-45% ethanol solutions,
Wherein ethanol solution accounts for 1~2 times of the volume of mixture, is then crossed 16-24 mesh sieves and obtains screenings, after drying the stem of noble dendrobium
Particle, stem of noble dendrobium particle and 3-5 parts magnesium stearate and 5-8 parts superfine silica gel powder are mixed and obtain stem of noble dendrobium buccal tablet after carrying out tabletting.
Preferably, in the preparation method of described stem of noble dendrobium buccal tablet, in the step 4, before tabletting, 30-70 parts are taken
It is divided into two parts after honeysuckle and 2~5 portions of peppermints grass are well mixed, during tabletting, is first filled with a copy of it honeysuckle and peppermint
The mixture of grass, refill the mixture of stem of noble dendrobium particle, magnesium stearate and superfine silica gel powder, the remaining a honeysuckle of finally filling and
The mixture of peppermint grass, tabletting is with obtained stem of noble dendrobium buccal tablet.
Preferably, the preparation method of described stem of noble dendrobium buccal tablet, also includes before the step 1:
Pre-treatment step:The fresh plant of the stem of noble dendrobium is cleaned up, 1-2mm segment is cut into, dries afterwards.
Preferably, the preparation method of described stem of noble dendrobium buccal tablet, after the pre-treatment step, the step 1 it
Before, in addition to color protection step:The fresh plant of the stem of noble dendrobium is immersed in into weight to carry out at color protection to soak 2-3h in its 1-2 times colour protecting liquid
Reason, wherein colour protecting liquid is made up of the composition of following mass percent:0.3% vitamin C, 0.3% citric acid, 0.12%
EDTA and 0.35% sodium sulfite and 98.93% water.
Preferably, in the preparation method of described stem of noble dendrobium buccal tablet, in the step 4, the method for the drying is:
The screenings that mistake 16-24 mesh sieves are obtained dry content to its reclaimed water under the conditions of 60 DEG C -65 DEG C is 2%-4%.
Contain dendrobe ultrafine powder in the stem of noble dendrobium buccal tablet of the present invention, particle is small, is easy to absorb;Added with appropriate in the present invention
Mannitol, have comfort, and its no hygroscopicity to oral cavity when edible, the performance to stem of noble dendrobium effective component has important;The present invention
It is middle to eat the stem of noble dendrobium, honeysuckle and peppermint grass mutual association, first, three has strong cloudy strengthening the essence, enriching yin tonifying lung, heat-clearing row with tableware
The effect of poison, anti-aging, second, the surface overcoats of buccal tablet are the mixture of honeysuckle and peppermint grass, make to suck in the edible stem of noble dendrobium
There is the layer variability in the sense of taste in piece.With the present invention stem of noble dendrobium buccal tablet dissolubility is good, delicate mouthfeel, nutritious, be easy to people
Body absorbs.
Method according to the present invention using complex enzyme digest the cell membrane of dendrobium plant so that stem of noble dendrobium alkali content is up to
0.50%, dendrobium polysaccharide content be up to 41% and amino acid content be up to 680mg/100g, greatly enhance the stem of noble dendrobium
The nutritive value of buccal tablet.
Embodiment
The present invention is described in further detail below, to make those skilled in the art being capable of evidence with reference to specification word
To implement.
The stem of noble dendrobium buccal tablet of the present invention can have following several different formula:
The stem of noble dendrobium sucks slice prescription 1:350 parts of dendrobe ultrafine powder, 240 parts of white sugar powder, 260 parts of mannitol and soluble starch
50 parts.
The stem of noble dendrobium sucks slice prescription 2:350 parts of dendrobe ultrafine powder, 240 parts of white sugar powder, 260 parts of mannitol, soluble starch
5 parts of 50 parts, 3 parts of magnesium stearate and superfine silica gel powder.
The stem of noble dendrobium sucks slice prescription 3:350 parts of dendrobe ultrafine powder, 240 parts of white sugar powder, 260 parts of mannitol, soluble starch
50 parts, 30 parts of honeysuckle and 5 parts of 2 parts of peppermint grass, 3 parts of magnesium stearate and superfine silica gel powder.
The stem of noble dendrobium sucks slice prescription 4:380 parts of dendrobe ultrafine powder, 360 parts of white sugar powder, 320 parts of mannitol, soluble starch
6 parts of 65 parts, 4 parts of magnesium stearate and superfine silica gel powder.
The stem of noble dendrobium sucks slice prescription 5:380 parts of dendrobe ultrafine powder, 360 parts of white sugar powder, 320 parts of mannitol, soluble starch
6 parts of 65 parts, 50 parts of honeysuckle, 3 parts of peppermint grass, 4 parts of magnesium stearate and superfine silica gel powder.
The stem of noble dendrobium sucks slice prescription 6:400 parts of dendrobe ultrafine powder, 360 parts of white sugar powder, 320 parts of mannitol and soluble starch
80 parts.
The stem of noble dendrobium sucks slice prescription 7:400 parts of dendrobe ultrafine powder, 360 parts of white sugar powder, 320 parts of mannitol, soluble starch
8 parts of 80 parts, 5 parts of magnesium stearate and superfine silica gel powder.
The stem of noble dendrobium sucks slice prescription 8:400 parts of dendrobe ultrafine powder, 360 parts of white sugar powder, 320 parts of mannitol, soluble starch
80 parts, 70 parts of honeysuckle and 8 parts of 5 parts of peppermint grass, 5 parts of magnesium stearate and superfine silica gel powder.
In an embodiment of the invention, the method for preparing stem of noble dendrobium buccal tablet, comprises the following steps:
(1) pre-treatment step:The fresh plant of the stem of noble dendrobium is cleaned up, 1mm segment is cut into, dries afterwards, is easy to crush.
(2) the fresh plant of the dried stem of noble dendrobium is subjected to color retention, is to soak the fresh plant of the stem of noble dendrobium the step of color retention
2h is soaked in weight is its 1 times colour protecting liquid and carries out color retention, wherein colour protecting liquid by following mass percent into packet
Into:0.3% vitamin C, 0.3% citric acid, 0.12% EDTA and 0.35% sodium sulfite and 98.93%
Water.
(3) 10 mesh sieves will be crossed after the fresh material disintegrating of the stem of noble dendrobium and obtains screenings, add 500,000 U/Kg cellulases, 1500U/ afterwards
Kg hemicellulases and 200,000 U/Kg protease, add after accounting for the water mixing of 0.6 times of the fresh material weight of the stem of noble dendrobium, in environmental wet
Spend for insulation enzymolysis 3h at 85% and 35 DEG C of temperature;
(4) stem of noble dendrobium after enzymolysis is freezed into 16h under the conditions of -45 DEG C, is ground be kneaded using oscillatory type ultramicro grinding afterwards
It is Ultramicro-powder that machine, which is ground crushing,;
(5) component of following parts by weight is mixed:350 parts of dendrobe ultrafine powder, 240 parts of white sugar powder, mannitol 260
50 parts of part and soluble starch, cross 75 mesh sieves by mixture afterwards and obtain screenings;
(6) mixture obtained in step (5) and mass percentage concentration ratio are mixed for 42% ethanol solution, wherein ethanol
Solution accounts for 1 times of the volume of mixture, is then crossed 16 mesh sieves and obtains screenings, stem of noble dendrobium particle is obtained after drying, by the stem of noble dendrobium
Grain obtains stem of noble dendrobium buccal tablet after mixing progress tabletting with 3 parts of magnesium stearates and 5 parts of superfine silica gel powders.Wherein, the side of the drying
Method is:It is 2% that the screenings that 16 mesh sieves obtain excessively, which is dried under the conditions of 60 DEG C to the content of its reclaimed water,.
Stem of noble dendrobium buccal tablet prepared by such scheme is adds honeysuckle and peppermint grass, in the step (6), in tabletting
Before, it is divided into two parts after 30 portions of honeysuckles and 2 portions of peppermints grass can also be taken well mixed, during tabletting, is first filled with a copy of it
Honeysuckle and the mixture of peppermint grass, refill the mixture of stem of noble dendrobium particle, magnesium stearate and superfine silica gel powder, finally filling is remaining
The mixture of a honeysuckle and peppermint grass, tabletting is with obtained stem of noble dendrobium buccal tablet.
In another embodiment of the present invention, the preparation method of stem of noble dendrobium buccal tablet specifically comprises the following steps:(1) pre- place
Manage step:The fresh plant of the stem of noble dendrobium is cleaned up, 2mm segment is cut into, dries afterwards, is easy to crush.
(2) the fresh plant of the dried stem of noble dendrobium is subjected to color retention, is to soak the fresh plant of the stem of noble dendrobium the step of color retention
3h is soaked in weight is its 2 times colour protecting liquid and carries out color retention, wherein colour protecting liquid by following mass percent into packet
Into:0.3% vitamin C, 0.3% citric acid, 0.12% EDTA and 0.35% sodium sulfite and 98.93%
Water.(3) 10 mesh sieves will be crossed after the fresh material disintegrating of the stem of noble dendrobium and obtains screenings, add 900,000 U/Kg cellulases, 2000U/Kg half afterwards
Cellulase and 250,000 U/Kg protease, add after accounting for the water mixing of 1.5 times of the fresh material weight of the stem of noble dendrobium, be in ambient humidity
95% and 42 DEG C of temperature at insulation enzymolysis 5h;
(4) stem of noble dendrobium after enzymolysis is freezed into 48h under the conditions of -50 DEG C, is ground be kneaded using oscillatory type ultramicro grinding afterwards
It is Ultramicro-powder that machine, which is ground crushing,;
(5) component of following parts by weight is mixed:400 parts of dendrobe ultrafine powder, 280 parts of white sugar powder, mannitol 280
80 parts of part and soluble starch, cross 75 mesh sieves by mixture afterwards and obtain screenings;
(6) mixture obtained in step (5) and mass percentage concentration ratio are mixed for 45% ethanol solution, wherein ethanol
Solution accounts for 2 times of the volume of mixture, is then crossed 24 mesh sieves and obtains screenings, stem of noble dendrobium particle is obtained after drying, by the stem of noble dendrobium
Grain obtains stem of noble dendrobium buccal tablet after mixing progress tabletting with 5 parts of magnesium stearates and 8 parts of superfine silica gel powders.Wherein, the side of the drying
Method is:It is 4% that the screenings that 24 mesh sieves obtain excessively, which is dried under the conditions of 65 DEG C to the content of its reclaimed water,.
Stem of noble dendrobium buccal tablet prepared by such scheme does not add honeysuckle and peppermint grass, in the step (6), in tabletting
Before, it is divided into two parts after 70 portions of honeysuckles and 5 portions of peppermints grass can also be taken well mixed, during tabletting, is first filled with a copy of it
Honeysuckle and the mixture of peppermint grass, refill the mixture of stem of noble dendrobium particle, magnesium stearate and superfine silica gel powder, finally filling is remaining
The mixture of a honeysuckle and peppermint grass, tabletting is with obtained stem of noble dendrobium buccal tablet.
In yet another embodiment of the present invention, the method for preparing stem of noble dendrobium buccal tablet comprises the following steps:
(1) pre-treatment step:The fresh plant of the stem of noble dendrobium is cleaned up, 1.5mm segment is cut into, dries afterwards, be easy to powder
It is broken.
(2) the fresh plant of the dried stem of noble dendrobium is subjected to color retention, is to soak the fresh plant of the stem of noble dendrobium the step of color retention
2h is soaked in weight is its 1 times colour protecting liquid and carries out color retention, wherein colour protecting liquid by following mass percent into packet
Into:0.3% vitamin C, 0.3% citric acid, 0.12% EDTA and 0.35% sodium sulfite and 98.93%
Water.
(3) 10 mesh sieves will be crossed after the fresh material disintegrating of the stem of noble dendrobium and obtains screenings, add 500,000 U/Kg cellulases, 1500U/ afterwards
Kg hemicellulases and 200,000 U/Kg protease, add after accounting for the water mixing of 1.0 times of the fresh material weight of the stem of noble dendrobium, in environmental wet
Spend for insulation enzymolysis 4h at 85% and 39 DEG C of temperature;
(4) stem of noble dendrobium after enzymolysis is freezed into 32h under the conditions of -48 DEG C, is ground be kneaded using oscillatory type ultramicro grinding afterwards
It is Ultramicro-powder that machine, which is ground crushing,;
(5) component of following parts by weight is mixed:380 parts of dendrobe ultrafine powder, 360 parts of white sugar powder, mannitol 320
65 parts of part and soluble starch, cross 75 mesh sieves by mixture afterwards and obtain screenings;
(6) mixture obtained in step (5) and mass percentage concentration ratio are mixed for 43% ethanol solution, wherein ethanol
Solution accounts for 1 times of the volume of mixture, is then crossed 20 mesh sieves and obtains screenings, stem of noble dendrobium particle is obtained after drying, by the stem of noble dendrobium
Grain obtains stem of noble dendrobium buccal tablet after mixing progress tabletting with 4 parts of magnesium stearates and 6 parts of superfine silica gel powders.Wherein, the side of the drying
Method is:It is 3% that the screenings that 16 mesh sieves obtain excessively, which is dried under the conditions of 63 DEG C to the content of its reclaimed water,.
In yet another embodiment of the present invention, the preparation method of stem of noble dendrobium buccal tablet comprises the following steps:
(1) pre-treatment step:The fresh plant of the stem of noble dendrobium is cleaned up, 1mm segment is cut into, dries afterwards, is easy to crush.
(2) 10 mesh sieves will be crossed after the fresh material disintegrating of the stem of noble dendrobium and obtains screenings, add 500,000 U/Kg cellulases, 1500U/ afterwards
Kg hemicellulases and 200,000 U/Kg protease, add after accounting for the water mixing of 0.6 times of the fresh material weight of the stem of noble dendrobium, in environmental wet
Spend for insulation enzymolysis 3h at 85% and 35 DEG C of temperature;
(3) stem of noble dendrobium after enzymolysis is freezed into 16h under the conditions of -45 DEG C, is ground be kneaded using oscillatory type ultramicro grinding afterwards
It is Ultramicro-powder that machine, which is ground crushing,;
(4) component of following parts by weight is mixed:350 parts of dendrobe ultrafine powder, 240 parts of white sugar powder, mannitol 260
50 parts of part and soluble starch, cross 75 mesh sieves by mixture afterwards and obtain screenings;
(5) mixture obtained in step (4) and mass percentage concentration ratio are mixed for 42% ethanol solution, wherein ethanol
Solution accounts for 1 times of the volume of mixture, is then crossed 16 mesh sieves and obtains screenings, stem of noble dendrobium particle is obtained after drying, by the stem of noble dendrobium
Grain obtains stem of noble dendrobium buccal tablet after mixing progress tabletting with 3 parts of magnesium stearates and 5 parts of superfine silica gel powders.Wherein, the side of the drying
Method is:It is 2% that the screenings that 16 mesh sieves obtain excessively, which is dried under the conditions of 60 DEG C to the content of its reclaimed water,.
Through it was found that, obtained buccal tablet has the characteristics of delicate mouthfeel, dissolubility are good after color retention, its sense organ
Index reaches 9.8 points
The method that applicant of the present invention is not added with complex enzyme according further to tradition is prepared for stem of noble dendrobium buccal tablet, including following step
Suddenly:
(1) pre-process:The fresh plant of the stem of noble dendrobium is selected, removes the impurity such as dead leaf, silt, is cleaned, cuts into 2mm section, is dried
It is standby, then carry out color retention;
(2) pretreated raw material be crushed into 10 mesh sieves with Roughpulverizer, then added by cellulase, hemicellulose
The complex enzyme of enzyme and protease composition, the dosage of complex enzyme are:500000 U/Kg cellulases, 1500U/Kg hemicellulases and
200000 U/Kg protease, complex enzyme is well mixed with the stem of noble dendrobium crushed, the amount for adding water is 1.5 times of stem of noble dendrobium quality, 42
DEG C insulation 5h, ambient humidity control 90%;
(3) stem of noble dendrobium for obtaining step (2) is freezed 48h, then ground using oscillatory type ultramicro grinding under the conditions of -50 DEG C
Mill kneading machine is ground into Ultramicro-powder;
(4) add by weight:400 parts of dendrobe ultrafine powder, 280 parts of white sugar powder, 280 parts of mannitol and soluble starch
80 parts, it is sufficiently mixed, crosses 75 mesh sieves;
(5) compound is mixed with ethanol, ethanol mass percentage concentration ratio is 45%, 24 mesh is then crossed, at 65 DEG C
Under the conditions of dry, make the content 4% of water, obtain particle;
(6) particle that step (5) obtains is mixed with 5 parts of magnesium stearates and 8 parts of superfine silica gel powders, carries out tabletting, stone is made
Dry measure used in former times health care buccal tablet.
The preparating example of stem of noble dendrobium health care buccal tablet sample of the present invention, its nutritive index and organoleptic analysis's such as following table:
It was found from data above analysis, the stem of noble dendrobium buccal tablet of the invention prepared, dendrobine, dendrobium polysaccharide, amino acid are used
Comparison example is above with the content of calcium phosphorus, compared with prior art, the present invention passes through stem of noble dendrobium mouth made from complex enzyme zymohydrolysis
Lozenge has nutritive value height, delicate mouthfeel, dissolubility good and is easy to the advantage of absorption of human body.
Although embodiment of the present invention is disclosed as above, it is not restricted in specification and embodiment listed
With it can be applied to various suitable the field of the invention completely, can be easily for those skilled in the art
Other modification is realized, therefore under the universal limited without departing substantially from claim and equivalency range, it is of the invention and unlimited
In specific details.
Claims (4)
- A kind of 1. preparation method of stem of noble dendrobium buccal tablet, it is characterised in that including:Step 1: obtain screenings by 10 mesh sieves are crossed after the fresh material disintegrating of the stem of noble dendrobium, add afterwards 50-90 ten thousand U/Kg cellulases, 1500-2000U/Kg hemicellulases and the U/Kg protease of 20-25 ten thousand, add and account for 0.6-1.5 times of the stem of noble dendrobium fresh material weight Water mix after, in ambient humidity be insulation enzymolysis 3-5h at 35-42 DEG C of 85%-95% and temperature;Step 2: the stem of noble dendrobium after enzymolysis is freezed into 16-48h under the conditions of -45--50 DEG C, it is Ultramicro-powder to crush afterwards;Step 3: the component of following parts by weight is mixed:It is dendrobe ultrafine powder 350-400 parts, white sugar powder 240-360 parts, sweet Reveal alcohol 260-320 parts and soluble starch 50-80 parts, mixture is crossed into 75 mesh sieves afterwards and obtains screenings;Step 4:The mixture obtained in step 3 and mass percentage concentration ratio are mixed for 42%-45% ethanol solutions, wherein Ethanol solution accounts for 1~2 times of the volume of mixture, is then crossed 16-24 mesh sieves and obtains screenings, and the stem of noble dendrobium is obtained after drying Grain, stem of noble dendrobium particle and 3-5 parts magnesium stearate and 5-8 parts superfine silica gel powder are mixed and obtain stem of noble dendrobium buccal tablet after carrying out tabletting, Before tabletting, two parts are divided into after taking 30-70 parts honeysuckle and 2~5 portions of peppermints grass well mixed, during tabletting, be first filled with wherein The mixture of a honeysuckle and peppermint grass, refills the mixture of stem of noble dendrobium particle, magnesium stearate and superfine silica gel powder, finally fills The mixture of remaining a honeysuckle and peppermint grass, tabletting is with obtained stem of noble dendrobium buccal tablet.
- 2. the preparation method of stem of noble dendrobium buccal tablet as claimed in claim 1, it is characterised in that also wrapped before the step 1 Include:Pre-treatment step:The fresh plant of the stem of noble dendrobium is cleaned up, 1-2mm segment is cut into, dries afterwards.
- 3. the preparation method of stem of noble dendrobium buccal tablet as claimed in claim 2, it is characterised in that after the pre-treatment step, institute Before stating step 1, in addition to color protection step:The fresh plant of the stem of noble dendrobium is immersed in weight to soak 2-3h in its 1-2 times colour protecting liquid Color retention is carried out, wherein colour protecting liquid is made up of the composition of following mass percent:0.3% vitamin C, 0.3% lemon Acid, 0.12% EDTA and 0.35% sodium sulfite and 98.93% water.
- 4. the preparation method of stem of noble dendrobium buccal tablet as claimed in claim 1, it is characterised in that in the step 4, the drying Method be:The screenings that mistake 16-24 mesh sieves are obtained dry content to its reclaimed water under the conditions of 60 DEG C -65 DEG C is 2%- 4%.
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CN104491478B (en) * | 2015-01-15 | 2017-09-15 | 福建农林大学 | A kind of sedum aizoon lozenge and preparation method thereof |
CN104705442A (en) * | 2015-03-31 | 2015-06-17 | 吴绍平 | Dendrobium officinale tea and preparation method thereof |
CN106546070A (en) * | 2015-09-16 | 2017-03-29 | 广西巴马兰长寿科技有限公司 | A kind of Herba Dendrobii microwave freeze-drying method |
CN105685963A (en) * | 2016-01-21 | 2016-06-22 | 广西大学 | Dendrobium officinale kimura ex migo digestion aiding tablet and preparation method thereof |
CN105707854A (en) * | 2016-01-28 | 2016-06-29 | 广西大学 | Herba dendrodii officinalis compound preparation and preparation method thereof |
CN106138040B (en) * | 2016-08-22 | 2019-01-18 | 南方医科大学 | Dendrobine is preparing the application in anti-influenza virus medicament |
CN108014270A (en) * | 2016-10-31 | 2018-05-11 | 四川德仁堂中药科技股份有限公司 | A kind of concocting method for improving rhizoma Gastrodiae powder drug effect and products thereof and purposes |
CN108208201A (en) * | 2018-02-11 | 2018-06-29 | 海南中椰科技有限公司 | It is a kind of can chewing natural coconut oil and preparation method thereof |
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CN103263588A (en) * | 2013-05-23 | 2013-08-28 | 重庆市中药研究院 | Compound buccal tablet containing dendrobium nobile and honeysuckle and preparation method thereof |
CN103285242A (en) * | 2013-05-23 | 2013-09-11 | 重庆市中药研究院 | Dendrobium buccal tablets and preparation method for same |
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CN103263588A (en) * | 2013-05-23 | 2013-08-28 | 重庆市中药研究院 | Compound buccal tablet containing dendrobium nobile and honeysuckle and preparation method thereof |
CN103285242A (en) * | 2013-05-23 | 2013-09-11 | 重庆市中药研究院 | Dendrobium buccal tablets and preparation method for same |
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