CN104257966A - Medicine for treating hypertension and preparation method thereof - Google Patents
Medicine for treating hypertension and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention discloses a medicine for treating hypertension. The medicine consists of the following six traditional Chinese medicines: ligusticum wallichii, safflower, cortex lycii radicis, betel nut, moutan bark and wolfberry. The traditional Chinese medicine composition can be prepared into the medicine. The experimental study proves that the medicine can be used for effectively treating the hypertension.
Description
Technical field
The invention belongs to the field of Chinese medicines.Be specifically related to one and prepare the hypertensive composition and method of making the same for the treatment of.
Background technology
Hypertension refers to not to be used in antihypertensive situation, systolic pressure >=140mmHg and/or diastolic pressure >=90mmHg, by blood pressure level, hypertension is divided into 1 grade (systolic pressure 140 ~ 159 diastolic pressure 90 ~ 99), 2 grades (systolic pressure 160 ~ 179 diastolic pressure 100 ~ 109), 3 grades (diastolic pressure >=110, systolic pressure >=180), systolic pressure >=140mmHg and diastolic pressure <90mmHg is single-row is isolated systolic hypertension.Patient previously has history of hypertension, uses antihypertensive at present, although blood pressure is lower than 140/90mmHg, also should be diagnosed as hypertension.
The symptom of hypertension, often because of people, different because of stadium.Early stage how asymptomatic or symptom is not obvious, occasionally to find in physical examination or due to during other reason measuring blood pressure.Common symptom has: dizziness, headache, agitation, cardiopalmus, insomnia, absent minded, hypomnesis, numb limbs and tense tendons, epistaxis, conjunctival hemorrhage, retinal hemorrhage, cerebral hemorrhage etc.
Current Therapeutic Method mostly is according to state of an illness reasonable employment antihypertensive drugs, blood pressure is maintained normally or close to normal level, to mitigation symptoms, delays disease progression and prevent the complication such as cerebrovas-cularaccident, heart failure and renal failure from having effect.Antihypertensive drugs kind is a lot, respectively has its feature, trends towards persistent at present, takes durative action preparation or the dosage form of number of times minimizing, uses to facilitate clothes for patients.Conventional antihypertensive drugs has: 1, diuretic hypotensive agent: hydrochlorothiazide, cyclopenthiazide, chlortalidone, furosemide etc.2, nervus centralis and sympathetic inhibitor: reserpine, verticil, clonidine hydrochloride.3, stagnant dose of adrenoreceptor group: beta-blocker is as propranolol, atenolol and metoprolol etc.; Alpha blocker such as Phenoxybenzamine, alpha+beta blocker such as willow ammonia benzyl are felt at ease.4, enzyme inhibitor is if angiotensin converting enzyme inhibitor is as captopril, enalapril etc.5, calcium ion antagonist is as nifedipine, amlodipine etc.6, vasodilation is as hydralazine, Minoxidil, prazosin, the pyridine of croak cyanogen etc.7, after neuroganglion and joint sympathetic inhibitor as guanethidine, the pyridine of tartaric acid five first croak etc.8,5-hydroxytryptamine receptor antagonist is as ketanserin etc.9, compound preparation is as FUFANG JIANGYA PIAN, FUFANG LUOBUMA PIAN, Adelgerpin etc.
Western medicine treatment hypertension in application more, but, also there is serious untoward reaction and side effect, if any medicine can affect water and electrolyte metabolism, affect blood fat, metabolism of blood glucose, some medicine long-term takings also may affect sexual function etc.; Meanwhile, in pressure reduction, fluctuation of blood pressure is comparatively large, particularly early stage or senile hypertension, and very responsive to Western medicine depressor, a medication blood pressure may fall too low, and even postural hypotension occurs, and reduce dosage or number of times, blood pressure may raise again very soon.Symptom improvement result is not as Chinese medicine, and after many patient's Western medicine, blood pressure has been down to normally, and subjective symptoms is still fairly obvious.
Chinese traditional treatment hypertension is with a long history, determined curative effect, and untoward reaction is few, hypertensive complication is also had to the effect of good prevention and therapy, and Traditional Chinese Medical on Treating Hypertension has obvious advantage, and Chinese medicine side effect is little, and can also eliminate the side effect of doctor trained in Western medicine; The antihypertensive effect of Chinese medicine is obvious, obviously can improve the quality of life of patient; Chinese medicine for lowering high blood pressure effect relaxes, and comparatively stable to the control of blood pressure, to slight or heavier high blood pressure disease, effectively can slow down fluctuation of blood pressure.The present invention passes through the discussion of hypertension science, method, prescription, drugs and the research of modern Chinese medicine pharmacology, adopt the Chinese prescription of medicine-food two-purpose, treatment hypertension, studies proved invention medicine by experiment and has obvious blood pressure lowering effect, be with a wide range of applications.
Summary of the invention
The object of the invention is exactly the defect in order to make up prior art, furthers investigate on hypertensive pathogenetic basis, provides one to prepare hypertensive medicine for the treatment of and preparation method thereof.The present invention's safety in clinical practice is good, does not find any untoward reaction.
The crude drug Rhizoma Chuanxiong of medicine of the present invention, Flos Carthami, Cortex Lycii, Semen Arecae, Cortex Moutan, Fructus Lycii Six-element Chinese medicine composition.
The part by weight of the raw material of medicine of the present invention is: Rhizoma Chuanxiong 10-20g, Flos Carthami 8-15g, Cortex Lycii 20-40g, 25-30g, Semen Arecae 6-15g, Cortex Moutan 10-30g, Fructus Lycii 10-20g.
The weight of the raw material of medicine of the present invention is preferably: Rhizoma Chuanxiong 15g, Flos Carthami 10g, Cortex Lycii 25g, Semen Arecae 10g, Cortex Moutan 20g, Fructus Lycii 15g.
The part by weight of the raw material of described medicine of the present invention is preferably: Rhizoma Chuanxiong 15g, Flos Carthami 10g, Cortex Lycii 30g, Semen Arecae 8g, Cortex Moutan 15g, Fructus Lycii 15g.
The part by weight of the raw material of medicine of the present invention is preferably: Rhizoma Chuanxiong 20g, Flos Carthami 8g, Cortex Lycii 20g, Semen Arecae 10g, Cortex Moutan 30g, Fructus Lycii 15g.
The active fraction preparation method of medicine of the present invention, be made up of following steps:
(1) medical material cleans: get prescription Chinese crude drug and clean respectively, take medical material;
(2) medicinal material extract: decoct with water twice, twice amount of water is respectively 6-10 times amount, and decocting time is 0.5-2 hour, and twice decoction liquor merges, and filters, and measuring relative density when being concentrated into 60 DEG C is the concentrated solution of 1.00-1.15, and drying both obtained active component.
The preparation formulation of medicine of the present invention is capsule, tablet, pill, granule, oral liquid, effervescent tablet or health beverage.
The preparation method of capsule of the present invention is made up of following steps:
(1) medical material cleans: get prescription Chinese crude drug and clean respectively, take medical material;
(2) medicinal material extract: decoct with water twice, twice amount of water is respectively 6-10 times amount, and decocting time is 0.5-2 hour, and twice decoction liquor merges, and filters, and measuring relative density when being concentrated into 60 DEG C is the concentrated solution of 1.00-1.15, for subsequent use;
(3) granulate, encapsulated: the concentrated solution getting step (2), add in the starch of concentrated solution 1-5 times weight, dextrin or lactose one or both, adopt thick paste granulation, granulate, dry at 50-70 DEG C, granulate, encapsulated, both obtained capsule.
The preparation method of Tablets has following steps to make:
(1) medical material cleans: get prescription Chinese crude drug and clean respectively, take medical material;
(2) medicinal material extract: decoct with water twice, twice amount of water is respectively 6-10 times amount, and decocting time is 0.5-2 hour, and twice decoction liquor merges, and filters, and measuring relative density when being concentrated into 60 DEG C is the concentrated solution of 1.00-1.15, for subsequent use;
(3) granulate: the concentrated solution getting step (2), add in the starch of concentrated solution 1-5 times weight, dextrin or lactose one or both, adopt thick paste granulation, granulate, dry at 50-70 DEG C, granulate, obtains granule for subsequent use;
(4) tabletting: remove step (3) gained granule, add the magnesium stearate of particle weight 0.5-1%, mix homogeneously, tabletting, both obtained tablet.
Preferred capsule preparation method thereof of the present invention, be made up of following steps:
(1) medical material cleans: get prescription Chinese crude drug and clean respectively, take medical material;
(2) medicinal material extract: decoct with water twice, twice amount of water is respectively 8 times amount, and decocting time is 1 hour, and twice decoction liquor merges, and filters, and measuring relative density when being concentrated into 60 DEG C is the concentrated solution of 1.10, for subsequent use;
(3) granulate, encapsulated: the concentrated solution getting step (2), adds the starch of concentrated solution 3 times of weight, adopts thick paste granulation, granulates, dry at 65 DEG C, and granulate is encapsulated, both capsule.
Preferred Tablets preparation method, be made up of following steps:
(1) medical material cleans: get prescription Chinese crude drug and clean respectively, take medical material;
(2) medicinal material extract: decoct with water twice, twice amount of water is respectively 8 times amount, and decocting time is 1 hour, and twice decoction liquor merges, and filters, and measuring relative density when being concentrated into 60 DEG C is the concentrated solution of 1.10, for subsequent use;
(3) granulate, encapsulated: the concentrated solution getting step (2), adds the starch of concentrated solution 3 times of weight, adopts thick paste granulation, granulates, dry at 68 DEG C, and granulate is encapsulated, both capsule.
In the present invention, Rhizoma Chuanxiong: bitter in the mouth, cold in nature, has heat clearing and damp drying, eliminating fire and detoxication, hemostasis, the effect such as antiabortive.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.
Flos Carthami: pungent, temperature.Enter the heart, Liver Channel.Promoting blood circulation to restore menstrual flow, blood stasis removing pain relieving.Control amenorrhea ， mass in the abdomen, difficult labour, stillborn fetus, disease that postpartum lochia can't go, blood stasis are had a pain, carbuncle, injury from falling down.
Cortex Lycii: sweet, cold, be clinically used for the treatment of hypertension, diabetes.
Semen Arecae: bitter, pungent, temperature.Return stomach, large intestine channel.Control killing insect and eliminating accumulation, circulation of qi promoting, diuretic, preventing the attack (or recurrence) of malaria." property of medicine opinion ": " declare the sharp vital organs of the human body to stop up stagnant, broken hard full gas, lower edema, controls pained, and wind accumulation of blood gathers.”
Cortex Moutan: bitter, pungent, is slightly cold.GUIXIN, liver, kidney channel.Function with cure mainly: clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.
Fructus Lycii: sweet, flat.Nourishing kidney, lung moistening, tonifying liver, improving eyesight.Control hepatic and renal YIN deficiency, soreness of the waist and knees, dizzy, dizzy, the many tear of blurred vision, cough due to consumptive disease, quenches one's thirst, seminal emission.
Advantage of the present invention is:
Chinese medicine of the present invention is through scientific and reasonable compatibility, and make effect of each medicine produce synergism, regulate cardiac function, have good curative effect for treatment hypertension, safe and reliable, side effect is little.
Embodiment:
Detailed description of the invention
Following embodiment is for illustrating the preparation of medicine of the present invention, but it can not form any restriction to scope of the present invention.
Embodiment 1:
For the ease of the application of medicine of the present invention, this medicine is prepared into capsule:
Crude drug proportioning: Rhizoma Chuanxiong 15g, Flos Carthami 10g, Cortex Lycii 25g, Semen Arecae 10g, Cortex Moutan 20g, Fructus Lycii 15g.
Preparation method:
(1) medical material cleans: get prescription Chinese crude drug and clean respectively, take medical material;
(2) medicinal material extract: decoct with water twice, twice amount of water is respectively 8 times amount, and decocting time is 1 hour, and twice decoction liquor merges, and filters, and measuring relative density when being concentrated into 60 DEG C is the concentrated solution of 1.10, for subsequent use;
(3) granulate, encapsulated: the concentrated solution getting step (2), adds the starch of concentrated solution 3 times of weight, adopts thick paste granulation, granulates, dry at 65 DEG C, and granulate is encapsulated, both capsule.
Embodiment 2:
For the ease of the application of medicine of the present invention, this medicine is prepared into tablet:
Crude drug proportioning: Rhizoma Chuanxiong 15g, Flos Carthami 10g, Cortex Lycii 25g, Semen Arecae 10g, Cortex Moutan 20g, Fructus Lycii 15g
Preparation method:
((1) medical material cleans: get prescription Chinese crude drug and clean respectively, take medical material;
(2) medicinal material extract: decoct with water twice, twice amount of water is respectively 10 times amount, and decocting time is 2 hours, and twice decoction liquor merges, and filters, and measuring relative density when being concentrated into 60 DEG C is the concentrated solution of 1.15, for subsequent use;
(3) granulate: the concentrated solution getting step (2), adds the starch of concentrated solution 4 times of weight, adopt thick paste granulation, granulate, dry at 65 DEG C, granulate, obtains granule for subsequent use;
(4) tabletting: remove step (3) gained granule, add the magnesium stearate of particle weight 0.5%, mix homogeneously, tabletting, both obtained tablet.
Embodiment 3:
For the ease of the application of medicine of the present invention, this medicine is prepared into capsule:
Crude drug proportioning: Rhizoma Chuanxiong 15g, Flos Carthami 10g, Cortex Lycii 30g, Semen Arecae 8g, Cortex Moutan 15g, Fructus Lycii 15g
Preparation method:
(1) medical material cleans: get prescription Chinese crude drug and clean respectively, take medical material;
(2) medicinal material extract: decoct with water twice, twice amount of water is respectively 6 times amount, and decocting time is 0.5 hour, and twice decoction liquor merges, and filters, and measuring relative density when being concentrated into 60 DEG C is the concentrated solution of 1.05, for subsequent use;
(3) granulate, encapsulated: the concentrated solution getting step (2), add the mixed accessories of the newborn sugar and starch of concentrated solution 2 times of weight, adopt thick paste granulation, granulate, dry at 60 DEG C, granulate, encapsulated, both obtained capsule, every capsules content of dispersion is equivalent to the 2-3g of former medicine.
Embodiment 4:
For the ease of the application of medicine of the present invention, this medicine is prepared into oral liquid:
Crude drug proportioning: Rhizoma Chuanxiong 15g, Flos Carthami 10g, Cortex Lycii 30g, Semen Arecae 8g, Cortex Moutan 15g, Fructus Lycii 15g.
Preparation method:
(1) medical material cleans: get prescription Chinese crude drug and clean respectively, take medical material;
(2) medicinal material extract: decoct with water twice, twice amount of water is respectively 7 times amount, and decocting time is 1 hour, and twice decoction liquor merges, and filters, and measuring relative density when being concentrated into 60 DEG C is the concentrated solution of 1.15, for subsequent use;
(3) oral liquid formulation is prepared into according to the preparation method of oral liquid routine
Embodiment 6:
For the ease of the application of medicine of the present invention, this medicine is prepared into granule:
Crude drug proportioning: Rhizoma Chuanxiong 20g, Flos Carthami 8g, Cortex Lycii 20g, Semen Arecae 10g, Cortex Moutan 30g, Fructus Lycii 15g.
Preparation method: formulation method makes granule routinely
Test example
There is the hypertensive effect for the treatment of, with having carried out following test by the medicine (hereinafter referred to as medicine of the present invention) obtained by embodiment 3 method for illustrating medicine of the present invention.
1 data and method
1.1 physical data choose 190 routine hyperpietics, all meet hypertension diagnosis mark that Chinese hypertension prevention and control guide revision committee formulates [Chinese hypertension prevention and control guide revision committee .2004 China hypertension prevention and control guide (practical this) [J]. Chinese Journal of Cardiology, 2004,32 (12): 1060-1064], systolic pressure >=140mmHg (1mmHg=0.133kPa) and/or diastolic pressure >=90mmHg.Patient is divided into treatment group and matched group at random.Treatment group 90 example, man 60 example, female 40 example, the mean age be (51.8 ± 7.1) year; Matched group 90 example, man 63 example, female 27 example, the mean age be (52.3 ± 7.5) year; Patient all gets rid of severe cardiac cerebrovascular disease etc.; Through statistics, two groups of there was no significant differences (P>0.05) in above-mentioned basic document, have comparability.
1.2 Therapeutic Method matched groups use Nifedipine sustained release tablets (10m g/ sheet, Dihon Pharmaceutical Group Yuxi Biopharmaceutical Co., Ltd.), 10mg/ time, every day 2 times.Treatment group adds on matched group basis uses medicine of the present invention, 3 tablets/time, and 2 times/day, the course for the treatment of is 1 month.
1.3 curative effect determinate standards: with effective in research, effectively add up to effectively total, specific standards is as follows, effective: diastolic pressure decline >=10mmHg (1mmHg=0.133kPa), and is down to normal or decline >=20mmHg; Effective: though diastolic pressure declines do not reach 10mmHg, to be down to normal or decline 10-19mmHg; Invalid: not reach above-mentioned level.
1.4 statistical procedures adopt SPSS13.0 statistical software to carry out date processing, and measurement data represents with mean ± standard deviation (X ± s), adopt t inspection, and enumeration data adopts x2 inspection.
2 results
2.1 Clinical efficacy comparisons are through statistics, and treatment group patient total effective rate is apparently higher than matched group (P < 0.05).The results are shown in Table 1.
Table 1 liang group patient clinical comparitive study (%)
Note: compare * P < 0.05 with matched group
Blood pressure result before and after 2.2 treatments, in table 2
Blood pressure before and after table 2 liang group treatment
Note: compared with before treatment, * P<0.05; Compare with after treatment of control group, #P<0.05.
2.3 symptom treatment effectiveness comparison: tcm symptom sign is respectively with reference to " guideline of clinical investigations of new Chinese medicine Hypertension " and People's Republic of China's traditional Chinese medicine industry standard.By tcm symptom sign with quantitative criteria be divided into without, light, in, to score heavily be respectively 0,2,4,6 point.Compare before and after two groups of tcm symptom treatments, difference has statistical significance (P<0.05), and after two groups of treatments, comparing difference has statistical significance (P<0.05), and treatment group is obviously better than matched group.(see table 3)
Before and after table 3 liang group tcm symptom treatment, integration improves situation
Note: compare with before treatment, * P<0.01; Compare with after treatment of control group, #P<0.01.
3.7 untoward reaction situations
3 conclusions
This research is on the basis of western medicine routine treatment, add Drug therapy of the present invention, at raising clinical efficacy, reducing blood pressure and improving in patient clinical symptom etc. is all better than simple western medical treatment, and abundant proved invention medicine has significant clinical efficacy to hypertension.
Claims (10)
1. treat a hypertensive medicine, by it is characterized in that described medicine is made up of Rhizoma Chuanxiong, Flos Carthami, Cortex Lycii, Semen Arecae, Cortex Moutan, Fructus Lycii Six-element Chinese medicine.
2. medicine according to claim 1, is characterized in that the part by weight of the raw material of described medicine is: Rhizoma Chuanxiong 10-20g, Flos Carthami 8-15g, Cortex Lycii 20-40g, 25-30g, Semen Arecae 6-15g, Cortex Moutan 10-30g, Fructus Lycii 10-20g.
3. medicine according to claim 2, is characterized in that the part by weight of the raw material of described medicine is: Rhizoma Chuanxiong 15g, Flos Carthami 10g, Cortex Lycii 25g, Semen Arecae 10g, Cortex Moutan 20g, Fructus Lycii 15g.
4. medicine according to claim 2, is characterized in that the part by weight of the raw material of described medicine is: Rhizoma Chuanxiong 15g, Flos Carthami 10g, Cortex Lycii 30g, Semen Arecae 8g, Cortex Moutan 15g, Fructus Lycii 15g.
5. medicine according to claim 2, is characterized in that the part by weight of the raw material of described medicine is: Rhizoma Chuanxiong 20g, Flos Carthami 8g, Cortex Lycii 20g, Semen Arecae 10g, Cortex Moutan 30g, Fructus Lycii 15g.
6., according to the active fraction preparation method of the arbitrary described medicine of claim 2-5, it is characterized in that the preparation method of described active component is made up of following steps:
(1) medical material cleans: get prescription Chinese crude drug and clean respectively, take medical material;
(2) medicinal material extract: decoct with water twice, twice amount of water is respectively 6-10 times amount, and decocting time is 0.5-2 hour, and twice decoction liquor merges, and filters, and measuring relative density when being concentrated into 60 DEG C is the concentrated solution of 1.00-1.15, and drying both obtained active component.
7., according to the arbitrary described medicine of claim 2-5, it is characterized in that the preparation formulation of described medicine is capsule, tablet, pill, granule, oral liquid.
8. medicine according to claim 7, is characterized in that the preparation method of described capsule is made up of following steps:
(1) medical material cleans: get prescription Chinese crude drug and clean respectively, take medical material;
(2) medicinal material extract: decoct with water twice, twice amount of water is respectively 6-10 times amount, and decocting time is 0.5-2 hour, and twice decoction liquor merges, and filters, and measuring relative density when being concentrated into 60 DEG C is the concentrated solution of 1.00-1.15, for subsequent use;
(3) granulate, encapsulated: the concentrated solution getting step (2), add in the starch of concentrated solution 1-5 times weight, dextrin or lactose one or both, adopt thick paste granulation, granulate, dry at 50-70 DEG C, granulate, encapsulated, both obtained capsule.
9. medicine according to claim 7, is characterized in that the preparation method of described tablet has following steps to make:
(1) medical material cleans: get prescription Chinese crude drug and clean respectively, take medical material;
(2) medicinal material extract: decoct with water twice, twice amount of water is respectively 6-10 times amount, and decocting time is 0.5-2 hour, and twice decoction liquor merges, and filters, and measuring relative density when being concentrated into 60 DEG C is the concentrated solution of 1.00-1.15, for subsequent use;
(3) granulate: the concentrated solution getting step (2), add in the starch of concentrated solution 1-5 times weight, dextrin or lactose one or both, adopt thick paste granulation, granulate, dry at 50-70 DEG C, granulate, obtains granule for subsequent use;
(4) tabletting: remove step (3) gained granule, add the magnesium stearate of particle weight 0.5-1%, mix homogeneously, tabletting, both obtained tablet.
10. medicine according to claim 8, is characterized in that the preparation method of described capsule is made up of following steps:
(1) medical material cleans: get prescription Chinese crude drug and clean respectively, take medical material;
(2) medicinal material extract: decoct with water twice, twice amount of water is respectively 8 times amount, and decocting time is 1 hour, and twice decoction liquor merges, and filters, and measuring relative density when being concentrated into 60 DEG C is the concentrated solution of 1.10, for subsequent use;
(3) granulate, encapsulated: the concentrated solution getting step (2), adds the starch of concentrated solution 3 times of weight, adopts thick paste granulation, granulates, dry at 68 DEG C, and granulate is encapsulated, both capsule.
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| CN201410521544.2A CN104257966A (en) | 2014-09-30 | 2014-09-30 | Medicine for treating hypertension and preparation method thereof |
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| CN1718137A (en) * | 2005-08-09 | 2006-01-11 | 余美君 | Medicinal pillow |
| CN102846699A (en) * | 2011-06-29 | 2013-01-02 | 湖南中医药大学 | Chinese medicinal composition for treating ischemic apoplexy and its preparation method |
| CN103409291A (en) * | 2013-08-23 | 2013-11-27 | 彭常安 | Preparation method of wintersweet cortex moutan wine |
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