CN104257793A - Cholestin and preparation method of cholestin - Google Patents
Cholestin and preparation method of cholestin Download PDFInfo
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- CN104257793A CN104257793A CN201410414642.6A CN201410414642A CN104257793A CN 104257793 A CN104257793 A CN 104257793A CN 201410414642 A CN201410414642 A CN 201410414642A CN 104257793 A CN104257793 A CN 104257793A
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- radix salviae
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Abstract
The invention relates to a Chinese herbal compound preparation, and discloses cholestin. The cholestin comprises, by weight, 800-950 parts of functional monascus red powder, 45-60 parts of salvia extracts, 20-30 parts of hawthorn extracts and 20-30 parts of semen cassiae extracts. The invention further discloses a preparation method of the cholestin. The preparation method particularly includes the steps of fermentation cultivation, inactivation processing, extract preparation, dosing and capsule filling. According to the cholestin and the preparation method of the cholestin, through the whole production process (such as cooking sterilization on smashed rice and smashed soybeans in the fermentation cultivation process and inactivation processing on monascus semi-finished products) of strain selection, bacterium cultivation methods (such as monascus seed cultivation under aseptic conditions), temperature regulation and control, fermentation technologies and the like, generation of citrinin in the fermentation process is controlled, and detection of an authority department proves that the content of the citrinin in the functional monascus conforms to international standards.
Description
Technical field
The Chinese medicine compound that the present invention relates to controls agent, particularly relates to Monas cuspurpureus Went capsule and preparation method thereof.
Background technology
Monas cuspurpureus Went is thought extremely precious health care tonic by the traditional Chinese medical science and is had good therapeutic efficiency to some disease.According to the theory of Chinese medicine, Monas cuspurpureus Went sweet in the mouth is warm in nature, has blood fat reducing, and reduce the effect such as low-density lipoprotein cholesterol and prevention cardiovascular and cerebrovascular disease, its effective ingredient is lovastatin and 5 kinds of analogs.
In general, existing functional Monascus industry is all faced with a difficult problem for three aspects: the first, and monascus ruber colonizes on rice, goes out natural statin through fermentating metabolism, also can produce harmful citrinin simultaneously; The second, lack the control ability high and low to " natural statin " content in Monas cuspurpureus Went; 3rd, lack and natural statin Activity and stabill is controlled.
Summary of the invention
The present invention is directed to existing in shortcoming, disclose Monas cuspurpureus Went capsule, also disclose the preparation method of Monas cuspurpureus Went capsule; Easy to prepare, condition is simple, safe and reliable, be applicable to suitability for industrialized production.
In order to solve the problems of the technologies described above, the present invention is solved by following technical proposals.
Monas cuspurpureus Went capsule, in following weight proportion, each component and content is, 800-950 part functional Monascus powder, 45-60 part Radix Salviae Miltiorrhizae extract, 20-30 part Fructus Crataegi extract, 20-30 part Semen Cassiae extract.
In functional Monascus selected by the present invention, contained natural statin is directly open loop carboxylic formula structure is main, can directly play a role, thus active high and good stability, and to human non-toxic's side effect.
As preferably, in following weight proportion, each component and content is, 890-950 part functional Monascus powder, 55-60 part Radix Salviae Miltiorrhizae extract, 26-30 part Fructus Crataegi extract, 26-30 part Semen Cassiae extract.The Monas cuspurpureus Went capsule of the raw material formation of this proportioning, drug effect is ideal.
As preferably, in following weight proportion, each component and content is, 900 parts of functional Monascus, 50 parts of Radix Salviae Miltiorrhizae extracts, 25 parts of Fructus Crataegi extracts, 25 parts of Semen Cassiae extracts.The Monas cuspurpureus Went capsule of the raw material formation of this proportioning, drug effect is ideal.
As preferably, every 1 capsules comprises following component: 800-950mg functional Monascus, 45-60mg Radix Salviae Miltiorrhizae extract, 20-30mg Fructus Crataegi extract, 20-30mg Semen Cassiae extract.
As preferably, every 1 capsules comprises following component: 900mg functional Monascus, 50mg Radix Salviae Miltiorrhizae extract, 25mg Fructus Crataegi extract, 25mg Semen Cassiae extract.The Monas cuspurpureus Went capsule of the raw material formation of this proportioning, drug effect is ideal.
The preparation method of above-described Monas cuspurpureus Went capsule, comprises the following steps,
A. Monas cuspurpureus Went Spawn preparation: aseptically access Monascus anka Nakazawa et sato, is placed in biochemical cultivation case, cultivates 7-8 days, obtain the alcoholic fermented product starter, the alcoholic fermented product starter is accessed shaking flask at 32-35 DEG C, cultivates 40-50 hour at 32-35 DEG C;
B. fermentation culture: rice and Semen sojae atricolor powder are broken to 40-60 order, after boiling sterilization, obtains rice meal and the soy powder blend of sterilizing, for subsequent use; Shake flask culture is accessed rice meal and the soy powder blend of sterilizing, be trained Monas cuspurpureus Went semi-finished product; Boiling sterilization after rice and Semen sojae atricolor being pulverized in fermentation culture process, has stopped the generation of miscellaneous bacteria and citrinin in sweat.
C. inactivation process: at 100-130 DEG C, by damp and hot for Monas cuspurpureus Went semi-finished product heating 50-65 minute, after the Monas cuspurpureus Went semi-finished product drying after inactivation process, is crushed to 50-65 order, obtains functional Monascus powder; At 100-130 DEG C, by damp and hot for Monas cuspurpureus Went semi-finished product heating 50-65 minute, stop the generation of miscellaneous bacteria and citrinin in sweat.
D. Radix Salviae Miltiorrhizae extract is prepared: get Radix Salviae Miltiorrhizae, through the impurity that sieves, cleaning, drying; Add water extraction 2-5 time, the weight of water is eight to the twelvefold of Radix Salviae Miltiorrhizae weight; Each extraction 1-2 hour, merge extractive liquid, is condensed into the thick extractum of Radix Salviae Miltiorrhizae; By thick for Radix Salviae Miltiorrhizae extract dry to moisture lower than 5%, then be crushed to 50-65 order, sieve, obtain Radix Salviae Miltiorrhizae extract;
E. Fructus Crataegi extract is prepared: get Fructus Crataegi, through the impurity that sieves, cleaning, drying; Add water extraction 2-5 time, the weight of water is eight to the twelvefold of Fructus Crataegi weight; Each extraction 1-2 hour, merge extractive liquid, is condensed into the thick extractum of Fructus Crataegi; By thick for Fructus Crataegi extract dry to moisture lower than 5%, then be crushed to 50-65 order, sieve, obtain Fructus Crataegi extract;
F. Semen Cassiae extract is prepared: depend on pine torch, through the impurity that sieves, cleaning, drying; Add water extraction 2-5 time, the weight of water is eight to the twelvefold of Semen Cassiae weight; Each extraction 1-2 hour, merge extractive liquid, is condensed into the thick extractum of Semen Cassiae; By thick for Semen Cassiae extract dry to moisture lower than 5%, then be crushed to 50-65 order, sieve, obtain Semen Cassiae extract;
G. batching and filled capsules: take functional Monascus powder, Radix Salviae Miltiorrhizae extract, Fructus Crataegi extract, Semen Cassiae extract by proportioning respectively, after mix homogeneously, encapsulating capsule.
As preferably, also comprise step H, polishing is carried out to the capsule of filling molding.
As preferably, in step D, through the impurity that sieves, cleaning, drying; Add water extraction 2 times, the weight of water is ten times of Radix Salviae Miltiorrhizae weight; Each extraction 1.5 hours, merge extractive liquid, is condensed into the thick extractum of Radix Salviae Miltiorrhizae; Thick for Radix Salviae Miltiorrhizae extractum is placed in vacuum drying oven, is dried to moisture lower than 5%, then be crushed to 60 orders, sieve, obtain Radix Salviae Miltiorrhizae extract.
As preferably, in step e, through the impurity that sieves, cleaning, drying; Add water extraction 2 times, the weight of water is ten times of Fructus Crataegi weight; Each extraction 1.5 hours, merge extractive liquid, is condensed into the thick extractum of Fructus Crataegi; Thick for Fructus Crataegi extractum is placed in vacuum drying oven, is dried to moisture lower than 5%, then be crushed to 60 orders, sieve, obtain Fructus Crataegi extract.
As preferably, in step F, through the impurity that sieves, cleaning, drying; Add water extraction 2 times, the weight of water is ten times of Semen Cassiae weight; Each extraction 1.5 hours, merge extractive liquid, is condensed into the thick extractum of Semen Cassiae; Thick for Semen Cassiae extractum is placed in vacuum drying oven, is dried to moisture lower than 5%, then be crushed to 60 orders, sieve, obtain Semen Cassiae extract.
Compared with prior art, beneficial effect of the present invention is:
(1) the natural statin in existing most of functional Monascus is exist with the form of ester type structure in closed loop substantially, itself does not all have activity, need under the effect of lactonase in human body, be hydrolyzed to open loop carboxylic formula structure, competence exertion effect, and the content of human body lactonase and activity variant, thus its curative effect varies with each individual.And contained natural statin is based on open loop carboxylic formula structure in functional Monascus selected by the present invention, can directly play a role, thus active high and good stability, and to human non-toxic's side effect.
(2) Radix Salviae Miltiorrhizae has stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, the effect of the relieving restlessness that clears away heart-fire.Fructus Crataegi has the effects such as blood fat reducing, blood pressure, heart tonifying, arrhythmia.Removing heat from the liver is longer than by Semen Cassiae, and intestine moistening is dry; For conjunctival congestion and swelling pain, constipation.Semen Cassiae presents on liver-yang disease persons such as disturbing, have a dizzy spell again for hypertension clinically.Holy Monas cuspurpureus Went capsule is rich in the functional Monascus of natural statin for primary raw material, with Radix Salviae Miltiorrhizae extract, Fructus Crataegi extract, Semen Cassiae extract with the use of time, adjusting blood lipid, blood circulation promoting and blood stasis dispelling, anticoagulant, enhancing fibrinolytic, antithrombotic can be played; And it is without any side effects to human body.
(3) the present invention is by selecting strain, educating the whole production processes such as bacterium method (as cultivated Monas cuspurpureus Went seed under aseptic condition), the regulation and control of temperature and fermentation technology (as boiling sterilization after rice and Semen sojae atricolor being pulverized in fermentation culture process, and inactivation process Monas cuspurpureus Went semi-finished product), control the generation of citrinin in sweat, detect through authoritative department and confirm, in functional Monascus of the present invention, the content of citrinin controls to meet international standard.
(4) in current existing functional Monascus, natural statin content is generally stabilized in 5 ‰ to 10 ‰, and peak also only reaches 16 ‰, and in functional Monascus of the present invention, the most high energy of natural statin content is stabilized in 30 ‰.In the research in more than 10 years of applicant, constantly research and development, accumulate and screen better more stable Monas cuspurpureus Went strain, and using Modern Molecular Biotechnology screening and through experimental reconstruction Monas cuspurpureus Went strain.Applicant adopts advanced SM-1 microbe fermentation method, updates fermentation technology and method, focuses on regulating and controlling temperature, humidity etc., controls fermentation period simultaneously, in the high automation degree environment of cleaning, obtain the natural statin of target product of this high-load.
(5) preparation method of the present invention, simple to operate, environmental protection, economy, efficient, nontoxic, have broad application prospects.
Detailed description of the invention
Embodiment 1
Monas cuspurpureus Went capsule, in following weight proportion, each component and content is, 800 parts of functional Monascus powder, 45 parts of Radix Salviae Miltiorrhizae extracts, 20 parts of Fructus Crataegi extracts, 20 parts of Semen Cassiae extracts.
The preparation method of above-described Monas cuspurpureus Went capsule, comprises the following steps,
A. Monas cuspurpureus Went Spawn preparation: aseptically access Monascus anka Nakazawa et sato, is placed in biochemical cultivation case, cultivates 7 days, obtain the alcoholic fermented product starter, the alcoholic fermented product starter is accessed shaking flask at 32 DEG C, cultivates 40 hours at 32 DEG C;
B. fermentation culture: rice and Semen sojae atricolor powder are broken to 40 orders, after boiling sterilization, obtains rice meal and the soy powder blend of sterilizing, for subsequent use; Shake flask culture is accessed rice meal and the soy powder blend of sterilizing, be trained Monas cuspurpureus Went semi-finished product;
C. inactivation process: at 100 DEG C, by damp and hot for Monas cuspurpureus Went semi-finished product heating 50 minutes, after the Monas cuspurpureus Went semi-finished product drying after inactivation process, is crushed to 50 orders, obtains functional Monascus powder;
D. Radix Salviae Miltiorrhizae extract is prepared: get Radix Salviae Miltiorrhizae, through the impurity that sieves, cleaning, drying; Add water extraction 2 times, the weight of water is the octuple of Radix Salviae Miltiorrhizae weight; Each extraction 1 hour, merge extractive liquid, is condensed into the thick extractum of Radix Salviae Miltiorrhizae; By thick for Radix Salviae Miltiorrhizae extract dry to moisture lower than 5%, then be crushed to 50 orders, sieve, obtain Radix Salviae Miltiorrhizae extract;
E. Fructus Crataegi extract is prepared: get Fructus Crataegi, through the impurity that sieves, cleaning, drying; Add water extraction 2 times, the weight of water is the octuple of Fructus Crataegi weight; Each extraction 1 hour, merge extractive liquid, is condensed into the thick extractum of Fructus Crataegi; By thick for Fructus Crataegi extract dry to moisture lower than 5%, then be crushed to 50 orders, sieve, obtain Fructus Crataegi extract;
F. Semen Cassiae extract is prepared: depend on pine torch, through the impurity that sieves, cleaning, drying; Add water extraction 2 times, the weight of water is the octuple of Semen Cassiae weight; Each extraction 1 hour, merge extractive liquid, is condensed into the thick extractum of Semen Cassiae; By thick for Semen Cassiae extract dry to moisture lower than 5%, then be crushed to 50 orders, sieve, obtain Semen Cassiae extract;
G. batching and filled capsules: take functional Monascus powder, Radix Salviae Miltiorrhizae extract, Fructus Crataegi extract, Semen Cassiae extract by proportioning respectively, after mix homogeneously, encapsulating capsule.
Embodiment 2
Monas cuspurpureus Went capsule, in following weight proportion, each component and content is, 950 parts of functional Monascus powder, 60 parts of Radix Salviae Miltiorrhizae extracts, 30 parts of Fructus Crataegi extracts, 30 parts of Semen Cassiae extracts.
The preparation method of above-described Monas cuspurpureus Went capsule, comprises the following steps,
A. Monas cuspurpureus Went Spawn preparation: aseptically access Monascus anka Nakazawa et sato, is placed in biochemical cultivation case, cultivates 8 days, obtain the alcoholic fermented product starter, the alcoholic fermented product starter is accessed shaking flask at 35 DEG C, cultivates 50 hours at 35 DEG C;
B. fermentation culture: rice and Semen sojae atricolor powder are broken to 60 orders, after boiling sterilization, obtains rice meal and the soy powder blend of sterilizing, for subsequent use; Shake flask culture is accessed rice meal and the soy powder blend of sterilizing, be trained Monas cuspurpureus Went semi-finished product;
C. inactivation process: at 130 DEG C, by damp and hot for Monas cuspurpureus Went semi-finished product heating 65 minutes, after the Monas cuspurpureus Went semi-finished product drying after inactivation process, is crushed to 65 orders, obtains functional Monascus powder;
D. Radix Salviae Miltiorrhizae extract is prepared: get Radix Salviae Miltiorrhizae, through the impurity that sieves, cleaning, drying; Add water extraction 5 times, the weight of water is the twelvefold of Radix Salviae Miltiorrhizae weight; Each extraction 2 hours, merge extractive liquid, is condensed into the thick extractum of Radix Salviae Miltiorrhizae; By thick for Radix Salviae Miltiorrhizae extract dry to moisture lower than 5%, then be crushed to 65 orders, sieve, obtain Radix Salviae Miltiorrhizae extract;
E. Fructus Crataegi extract is prepared: get Fructus Crataegi, through the impurity that sieves, cleaning, drying; Add water extraction 5 times, the weight of water is the twelvefold of Fructus Crataegi weight; Each extraction 2 hours, merge extractive liquid, is condensed into the thick extractum of Fructus Crataegi; By thick for Fructus Crataegi extract dry to moisture lower than 5%, then be crushed to 65 orders, sieve, obtain Fructus Crataegi extract;
F. Semen Cassiae extract is prepared: depend on pine torch, through the impurity that sieves, cleaning, drying; Add water extraction 5 times, the weight of water is the twelvefold of Semen Cassiae weight; Each extraction 2 hours, merge extractive liquid, is condensed into the thick extractum of Semen Cassiae; By thick for Semen Cassiae extract dry to moisture lower than 5%, then be crushed to 65 orders, sieve, obtain Semen Cassiae extract;
G. batching and filled capsules: take functional Monascus powder, Radix Salviae Miltiorrhizae extract, Fructus Crataegi extract, Semen Cassiae extract by proportioning respectively, after mix homogeneously, encapsulating capsule;
H. polishing is carried out to the capsule of filling molding.
Embodiment 3
Monas cuspurpureus Went capsule, in following weight proportion, each component and content is, 890 parts of functional Monascus powder, 55 parts of Radix Salviae Miltiorrhizae extracts, 26 parts of Fructus Crataegi extracts, 26 parts of Semen Cassiae extracts.
The preparation method of above-described Monas cuspurpureus Went capsule, comprises the following steps,
A. Monas cuspurpureus Went Spawn preparation: aseptically access Monascus anka Nakazawa et sato, is placed in biochemical cultivation case, cultivates 7.5 days, obtain the alcoholic fermented product starter, the alcoholic fermented product starter is accessed shaking flask at 33 DEG C, cultivates 48 hours at 33 DEG C;
B. fermentation culture: rice and Semen sojae atricolor powder are broken to 50 orders, after boiling sterilization, obtains rice meal and the soy powder blend of sterilizing, for subsequent use; Shake flask culture is accessed rice meal and the soy powder blend of sterilizing, be trained Monas cuspurpureus Went semi-finished product;
C. inactivation process: at 120 DEG C, by damp and hot for Monas cuspurpureus Went semi-finished product heating 60 minutes, after the Monas cuspurpureus Went semi-finished product drying after inactivation process, is crushed to 60 orders, obtains functional Monascus powder;
D. Radix Salviae Miltiorrhizae extract is prepared: get Radix Salviae Miltiorrhizae, through the impurity that sieves, cleaning, drying; Add water extraction 3 times, the weight of water is ten times of Radix Salviae Miltiorrhizae weight; Each extraction 1.5 hours, merge extractive liquid, is condensed into the thick extractum of Radix Salviae Miltiorrhizae; Thick for Radix Salviae Miltiorrhizae extractum is placed in vacuum drying oven, is dried to moisture lower than 5%, then be crushed to 60 orders, sieve, obtain Radix Salviae Miltiorrhizae extract;
E. Fructus Crataegi extract is prepared: get Fructus Crataegi, through the impurity that sieves, cleaning, drying; Add water extraction 3 times, the weight of water is ten times of Fructus Crataegi weight; Each extraction 1.5 hours, merge extractive liquid, is condensed into the thick extractum of Fructus Crataegi; Thick for Fructus Crataegi extractum is placed in vacuum drying oven, is dried to moisture lower than 5%, then be crushed to 60 orders, sieve, obtain Fructus Crataegi extract.
F. Semen Cassiae extract is prepared: depend on pine torch, through the impurity that sieves, cleaning, drying; Add water extraction 3 times, the weight of water is ten times of Fructus Crataegi weight; Each extraction 1.5 hours, merge extractive liquid, is condensed into the thick extractum of Fructus Crataegi; Thick for Fructus Crataegi extractum is placed in vacuum drying oven, is dried to moisture lower than 5%, then be crushed to 60 orders, sieve, obtain Fructus Crataegi extract;
G. batching and filled capsules: take functional Monascus powder, Radix Salviae Miltiorrhizae extract, Fructus Crataegi extract, Semen Cassiae extract by proportioning respectively, after mix homogeneously, encapsulating capsule.
Embodiment 4
Monas cuspurpureus Went capsule, in following weight proportion, each component and content is, 900 parts of functional Monascus, 50 parts of Radix Salviae Miltiorrhizae extracts, 25 parts of Fructus Crataegi extracts, 25 parts of Semen Cassiae extracts.
The preparation method of above-described Monas cuspurpureus Went capsule, comprises the following steps,
A. Monas cuspurpureus Went Spawn preparation: aseptically access Monascus anka Nakazawa et sato, is placed in biochemical cultivation case, cultivates 7 days, obtain the alcoholic fermented product starter, the alcoholic fermented product starter is accessed shaking flask at 32 DEG C, cultivates 40 hours at 32 DEG C;
B. fermentation culture: rice and Semen sojae atricolor powder are broken to 40 orders, after boiling sterilization, obtains rice meal and the soy powder blend of sterilizing, for subsequent use; Shake flask culture is accessed rice meal and the soy powder blend of sterilizing, be trained Monas cuspurpureus Went semi-finished product;
C. inactivation process: at 100 DEG C, by damp and hot for Monas cuspurpureus Went semi-finished product heating 50 minutes, after the Monas cuspurpureus Went semi-finished product drying after inactivation process, is crushed to 50 orders, obtains functional Monascus powder;
D. Radix Salviae Miltiorrhizae extract is prepared: get Radix Salviae Miltiorrhizae, through the impurity that sieves, cleaning, drying; Add water extraction 2 times, the weight of water is the octuple of Radix Salviae Miltiorrhizae weight; Each extraction 1 hour, merge extractive liquid, is condensed into the thick extractum of Radix Salviae Miltiorrhizae; By thick for Radix Salviae Miltiorrhizae extract dry to moisture lower than 5%, then be crushed to 50 orders, sieve, obtain Radix Salviae Miltiorrhizae extract;
E. Fructus Crataegi extract is prepared: get Fructus Crataegi, through the impurity that sieves, cleaning, drying; Add water extraction 2 times, the weight of water is the octuple of Fructus Crataegi weight; Each extraction 1 hour, merge extractive liquid, is condensed into the thick extractum of Fructus Crataegi; By thick for Fructus Crataegi extract dry to moisture lower than 5%, then be crushed to 50 orders, sieve, obtain Fructus Crataegi extract;
F. Semen Cassiae extract is prepared: depend on pine torch, through the impurity that sieves, cleaning, drying; Add water extraction 2 times, the weight of water is the octuple of Semen Cassiae weight; Each extraction 1 hour, merge extractive liquid, is condensed into the thick extractum of Semen Cassiae; By thick for Semen Cassiae extract dry to moisture lower than 5%, then be crushed to 50 orders, sieve, obtain Semen Cassiae extract;
G. batching and filled capsules: take functional Monascus powder, Radix Salviae Miltiorrhizae extract, Fructus Crataegi extract, Semen Cassiae extract by proportioning respectively, after mix homogeneously, encapsulating capsule.
Embodiment 5
Monas cuspurpureus Went capsule, every 1 capsules comprises following component: 800mg functional Monascus, 45mg Radix Salviae Miltiorrhizae extract, 20mg Fructus Crataegi extract, 20mg Semen Cassiae extract.
The preparation method of above-described Monas cuspurpureus Went capsule, comprises the following steps,
A. Monas cuspurpureus Went Spawn preparation: aseptically access Monascus anka Nakazawa et sato, is placed in biochemical cultivation case, cultivates 7.2 days, obtain the alcoholic fermented product starter, the alcoholic fermented product starter is accessed shaking flask at 32.5 DEG C, cultivates 41 hours at 32.5 DEG C;
B. fermentation culture: rice and Semen sojae atricolor powder are broken to 41 orders, after boiling sterilization, obtains rice meal and the soy powder blend of sterilizing, for subsequent use; Shake flask culture is accessed rice meal and the soy powder blend of sterilizing, be trained Monas cuspurpureus Went semi-finished product;
C. inactivation process: at 115 DEG C, by damp and hot for Monas cuspurpureus Went semi-finished product heating 51 minutes, after the Monas cuspurpureus Went semi-finished product drying after inactivation process, is crushed to 51 orders, obtains functional Monascus powder;
D. Radix Salviae Miltiorrhizae extract is prepared: get Radix Salviae Miltiorrhizae, through the impurity that sieves, cleaning, drying; Add water extraction 3 times, the weight of water is nine times of Radix Salviae Miltiorrhizae weight; Each extraction 1.5 hours, merge extractive liquid, is condensed into the thick extractum of Radix Salviae Miltiorrhizae; By thick for Radix Salviae Miltiorrhizae extract dry to moisture lower than 5%, then be crushed to 55 orders, sieve, obtain Radix Salviae Miltiorrhizae extract;
E. Fructus Crataegi extract is prepared: get Fructus Crataegi, through the impurity that sieves, cleaning, drying; Add water extraction 3 times, the weight of water is nine times of Fructus Crataegi weight; Each extraction 1.5 hours, merge extractive liquid, is condensed into the thick extractum of Fructus Crataegi; By thick for Fructus Crataegi extract dry to moisture lower than 5%, then be crushed to 55 orders, sieve, obtain Fructus Crataegi extract;
F. Semen Cassiae extract is prepared: depend on pine torch, through the impurity that sieves, cleaning, drying; Add water extraction 3 times, the weight of water is nine times of Semen Cassiae weight; Each extraction 1.5 hours, merge extractive liquid, is condensed into the thick extractum of Semen Cassiae; By thick for Semen Cassiae extract dry to moisture lower than 5%, then be crushed to 55 orders, sieve, obtain Semen Cassiae extract;
G. batching and filled capsules: take functional Monascus powder, Radix Salviae Miltiorrhizae extract, Fructus Crataegi extract, Semen Cassiae extract by proportioning respectively, after mix homogeneously, encapsulating capsule.
Embodiment 6
Monas cuspurpureus Went capsule, every 1 capsules comprises following component: 800-950mg functional Monascus, 45-60mg Radix Salviae Miltiorrhizae extract, 20-30mg Fructus Crataegi extract, 20-30mg Semen Cassiae extract.
The preparation method of above-described Monas cuspurpureus Went capsule, comprises the following steps,
A. Monas cuspurpureus Went Spawn preparation: aseptically access Monascus anka Nakazawa et sato, is placed in biochemical cultivation case, cultivates 7-8 days, obtain the alcoholic fermented product starter, the alcoholic fermented product starter is accessed shaking flask at 32-35 DEG C, cultivates 48 hours at 34.5 DEG C;
B. fermentation culture: rice and Semen sojae atricolor powder are broken to 56 orders, after boiling sterilization, obtains rice meal and the soy powder blend of sterilizing, for subsequent use; Shake flask culture is accessed rice meal and the soy powder blend of sterilizing, be trained Monas cuspurpureus Went semi-finished product;
C. inactivation process: at 125 DEG C, by damp and hot for Monas cuspurpureus Went semi-finished product heating 63 minutes, after the Monas cuspurpureus Went semi-finished product drying after inactivation process, is crushed to 63 orders, obtains functional Monascus powder;
D. Radix Salviae Miltiorrhizae extract is prepared: get Radix Salviae Miltiorrhizae, through the impurity that sieves, cleaning, drying; Add water extraction 4 times, the weight of water is 11 times of Radix Salviae Miltiorrhizae weight; Each extraction 1.8 hours, merge extractive liquid, is condensed into the thick extractum of Radix Salviae Miltiorrhizae; By thick for Radix Salviae Miltiorrhizae extract dry to moisture lower than 5%, then be crushed to 63 orders, sieve, obtain Radix Salviae Miltiorrhizae extract;
E. Fructus Crataegi extract is prepared: get Fructus Crataegi, through the impurity that sieves, cleaning, drying; Add water extraction 4 times, the weight of water is 11 times of Fructus Crataegi weight; Each extraction 1.8 hours, merge extractive liquid, is condensed into the thick extractum of Fructus Crataegi; By thick for Fructus Crataegi extract dry to moisture lower than 5%, then be crushed to 63 orders, sieve, obtain Fructus Crataegi extract;
F. Semen Cassiae extract is prepared: depend on pine torch, through the impurity that sieves, cleaning, drying; Add water extraction 4 times, the weight of water is eight to the twelvefold of Semen Cassiae weight; Each extraction 1.8 hours, merge extractive liquid, is condensed into the thick extractum of Semen Cassiae; By thick for Semen Cassiae extract dry to moisture lower than 5%, then be crushed to 63 orders, sieve, obtain Semen Cassiae extract;
G. batching and filled capsules: take functional Monascus powder, Radix Salviae Miltiorrhizae extract, Fructus Crataegi extract, Semen Cassiae extract by proportioning respectively, after mix homogeneously, encapsulating capsule.
Embodiment 7
Monas cuspurpureus Went capsule, every 1 capsules comprises following component: 900mg functional Monascus, 50mg Radix Salviae Miltiorrhizae extract, 25mg Fructus Crataegi extract, 25mg Semen Cassiae extract.
The preparation method of above-described Monas cuspurpureus Went capsule, comprises the following steps,
A. Monas cuspurpureus Went Spawn preparation: aseptically access Monascus anka Nakazawa et sato, is placed in biochemical cultivation case, cultivates 8 days, obtain the alcoholic fermented product starter, the alcoholic fermented product starter is accessed shaking flask at 35 DEG C, cultivates 50 hours at 35 DEG C;
B. fermentation culture: rice and Semen sojae atricolor powder are broken to 60 orders, after boiling sterilization, obtains rice meal and the soy powder blend of sterilizing, for subsequent use; Shake flask culture is accessed rice meal and the soy powder blend of sterilizing, be trained Monas cuspurpureus Went semi-finished product;
C. inactivation process: at 130 DEG C, by damp and hot for Monas cuspurpureus Went semi-finished product heating 65 minutes, after the Monas cuspurpureus Went semi-finished product drying after inactivation process, is crushed to 65 orders, obtains functional Monascus powder;
D. Radix Salviae Miltiorrhizae extract is prepared: get Radix Salviae Miltiorrhizae, through the impurity that sieves, cleaning, drying; Add water extraction 5 times, the weight of water is the twelvefold of Radix Salviae Miltiorrhizae weight; Each extraction 2 hours, merge extractive liquid, is condensed into the thick extractum of Radix Salviae Miltiorrhizae; By thick for Radix Salviae Miltiorrhizae extract dry to moisture lower than 5%, then be crushed to 65 orders, sieve, obtain Radix Salviae Miltiorrhizae extract;
E. Fructus Crataegi extract is prepared: get Fructus Crataegi, through the impurity that sieves, cleaning, drying; Add water extraction 5 times, the weight of water is the twelvefold of Fructus Crataegi weight; Each extraction 2 hours, merge extractive liquid, is condensed into the thick extractum of Fructus Crataegi; By thick for Fructus Crataegi extract dry to moisture lower than 5%, then be crushed to 65 orders, sieve, obtain Fructus Crataegi extract;
F. Semen Cassiae extract is prepared: depend on pine torch, through the impurity that sieves, cleaning, drying; Add water extraction 5 times, the weight of water is the twelvefold of Semen Cassiae weight; Each extraction 2 hours, merge extractive liquid, is condensed into the thick extractum of Semen Cassiae; By thick for Semen Cassiae extract dry to moisture lower than 5%, then be crushed to 65 orders, sieve, obtain Semen Cassiae extract;
G. batching and filled capsules: take functional Monascus powder, Radix Salviae Miltiorrhizae extract, Fructus Crataegi extract, Semen Cassiae extract by proportioning respectively, after mix homogeneously, encapsulating capsule;
H. polishing is carried out to the capsule of filling molding.
In a word, the foregoing is only preferred embodiment of the present invention, all equalizations done according to the present patent application the scope of the claims change and modify, and all should belong to the covering scope of patent of the present invention.
Claims (10)
1. Monas cuspurpureus Went capsule, is characterized in that: in following weight proportion, and each component and content is, 800-950 part functional Monascus powder, 45-60 part Radix Salviae Miltiorrhizae extract, 20-30 part Fructus Crataegi extract, 20-30 part Semen Cassiae extract.
2. Monas cuspurpureus Went capsule according to claim 1, is characterized in that: in following weight proportion, and each component and content is, 890-950 part functional Monascus powder, 55-60 part Radix Salviae Miltiorrhizae extract, 26-30 part Fructus Crataegi extract, 26-30 part Semen Cassiae extract.
3. Monas cuspurpureus Went capsule according to claim 1, is characterized in that: in following weight proportion, and each component and content is, 900 parts of functional Monascus, 50 parts of Radix Salviae Miltiorrhizae extracts, 25 parts of Fructus Crataegi extracts, 25 parts of Semen Cassiae extracts.
4. Monas cuspurpureus Went capsule according to claim 1, is characterized in that: every 1 capsules comprises following component: 800-950mg functional Monascus, 45-60mg Radix Salviae Miltiorrhizae extract, 20-30mg Fructus Crataegi extract, 20-30mg Semen Cassiae extract.
5. Monas cuspurpureus Went capsule according to claim 4, is characterized in that: every 1 capsules comprises following component: 900mg functional Monascus, 50mg Radix Salviae Miltiorrhizae extract, 25mg Fructus Crataegi extract, 25mg Semen Cassiae extract.
6. the preparation method of Monas cuspurpureus Went capsule according to claim 1, is characterized in that: comprise the following steps,
A. Monas cuspurpureus Went Spawn preparation: aseptically access Monascus anka Nakazawa et sato, is placed in biochemical cultivation case, cultivates 7-8 days, obtain the alcoholic fermented product starter, the alcoholic fermented product starter is accessed shaking flask at 32-35 DEG C, cultivates 40-50 hour at 32-35 DEG C;
B. fermentation culture: rice and Semen sojae atricolor powder are broken to 40-60 order, after boiling sterilization, obtains rice meal and the soy powder blend of sterilizing, for subsequent use; Shake flask culture is accessed rice meal and the soy powder blend of sterilizing, be trained Monas cuspurpureus Went semi-finished product;
C. inactivation process: at 100-130 DEG C, by damp and hot for Monas cuspurpureus Went semi-finished product heating 50-65 minute, after the Monas cuspurpureus Went semi-finished product drying after inactivation process, is crushed to 50-65 order, obtains functional Monascus powder;
D. Radix Salviae Miltiorrhizae extract is prepared: get Radix Salviae Miltiorrhizae, through the impurity that sieves, cleaning, drying; Add water extraction 2-5 time, the weight of water is eight to the twelvefold of Radix Salviae Miltiorrhizae weight; Each extraction 1-2 hour, merge extractive liquid, is condensed into the thick extractum of Radix Salviae Miltiorrhizae; By thick for Radix Salviae Miltiorrhizae extract dry to moisture lower than 5%, then be crushed to 50-65 order, sieve, obtain Radix Salviae Miltiorrhizae extract;
E. Fructus Crataegi extract is prepared: get Fructus Crataegi, through the impurity that sieves, cleaning, drying; Add water extraction 2-5 time, the weight of water is eight to the twelvefold of Fructus Crataegi weight; Each extraction 1-2 hour, merge extractive liquid, is condensed into the thick extractum of Fructus Crataegi; By thick for Fructus Crataegi extract dry to moisture lower than 5%, then be crushed to 50-65 order, sieve, obtain Fructus Crataegi extract;
F. Semen Cassiae extract is prepared: depend on pine torch, through the impurity that sieves, cleaning, drying; Add water extraction 2-5 time, the weight of water is eight to the twelvefold of Semen Cassiae weight; Each extraction 1-2 hour, merge extractive liquid, is condensed into the thick extractum of Semen Cassiae; By thick for Semen Cassiae extract dry to moisture lower than 5%, then be crushed to 50-65 order, sieve, obtain Semen Cassiae extract;
G. batching and filled capsules: take functional Monascus powder, Radix Salviae Miltiorrhizae extract, Fructus Crataegi extract, Semen Cassiae extract by proportioning respectively, after mix homogeneously, encapsulating capsule.
7. the preparation method of Monas cuspurpureus Went capsule according to claim 6, is characterized in that: also comprise step H, carries out polishing to the capsule of filling molding.
8. the preparation method of Monas cuspurpureus Went capsule according to claim 6, is characterized in that: in step D, through the impurity that sieves, cleaning, drying; Add water extraction 2 times, the weight of water is ten times of Radix Salviae Miltiorrhizae weight; Each extraction 1.5 hours, merge extractive liquid, is condensed into the thick extractum of Radix Salviae Miltiorrhizae; Thick for Radix Salviae Miltiorrhizae extractum is placed in vacuum drying oven, is dried to moisture lower than 5%, then be crushed to 60 orders, sieve, obtain Radix Salviae Miltiorrhizae extract.
9. the preparation method of Monas cuspurpureus Went capsule according to claim 6, is characterized in that: in step e, through the impurity that sieves, cleaning, drying; Add water extraction 2 times, the weight of water is ten times of Fructus Crataegi weight; Each extraction 1.5 hours, merge extractive liquid, is condensed into the thick extractum of Fructus Crataegi; Thick for Fructus Crataegi extractum is placed in vacuum drying oven, is dried to moisture lower than 5%, then be crushed to 60 orders, sieve, obtain Fructus Crataegi extract.
10. the preparation method of Monas cuspurpureus Went capsule according to claim 6, is characterized in that: in step F, through the impurity that sieves, cleaning, drying; Add water extraction 2 times, the weight of water is ten times of Semen Cassiae weight; Each extraction 1.5 hours, merge extractive liquid, is condensed into the thick extractum of Semen Cassiae; Thick for Semen Cassiae extractum is placed in vacuum drying oven, is dried to moisture lower than 5%, then be crushed to 60 orders, sieve, obtain Semen Cassiae extract.
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Application publication date: 20150107 |