CN104257742A - Mosquito bite prevention cream and synthesis method thereof - Google Patents

Mosquito bite prevention cream and synthesis method thereof Download PDF

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Publication number
CN104257742A
CN104257742A CN201410534069.2A CN201410534069A CN104257742A CN 104257742 A CN104257742 A CN 104257742A CN 201410534069 A CN201410534069 A CN 201410534069A CN 104257742 A CN104257742 A CN 104257742A
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China
Prior art keywords
container
extracting solution
peg
percent
stir
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Pending
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CN201410534069.2A
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Chinese (zh)
Inventor
张龙军
周奎
彭益文
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ZHEJIANG YILUTE BIOTECHNOLOGY Co Ltd
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ZHEJIANG YILUTE BIOTECHNOLOGY Co Ltd
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Priority to CN201410534069.2A priority Critical patent/CN104257742A/en
Publication of CN104257742A publication Critical patent/CN104257742A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A61K31/79—Polymers of vinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

Abstract

The invention discloses mosquito bite prevention cream and a synthesis method for thereof. The mosquito bite prevention cream comprises the following raw materials in percentage by mass: 3 to 10 percent of povidone iodine, 30 to 50 percent of polyethylene glycol-4000, 3 to 25 percent of polyethylene glycol-400, 3 to 8 percent of glycerin, 0.1 to 0.5 percent of ethyl 4-hydroxybenzoate, 0.5 to 1.5 percent of peppermint oil, 0.2 to 1 percent of Artemisia vulgaris extract, 0.2 to 1 percent of lavender extract, 0.1 to 1 percent of vitamin E and 15 to 40 percent of pure water. According to the mosquito bite prevention cream and the synthesis method thereof, polyethylene glycol is taken as a substrate, and is combined with mosquito bite prevention auxiliaries to synthesize the mosquito bite prevention cream with stable character; the method is convenient, easy and suitable for industrial production, and the product is stable.

Description

A kind of mosquito proof bites emulsifiable paste and synthetic method thereof
Technical field
The present invention relates to household chemicals technical field, specifically a kind of mosquito proof bites emulsifiable paste and synthetic method thereof.
Background technology
In summer, mosquito grows, a lot of people often by mosquito bite, as prevented and treated not in time, the person of being snapped light then red swelling of the skin, from head to foot pruritus, heavy then likely infect infectious disease, badly influence daily life and work.The product that current mosquito control common is on the market bitten is a lot, but major part all has the following disadvantages: effect is undesirable, complicated process of preparation, easily has side effects.
Summary of the invention
A kind of simple, stable mosquito proof is the object of the present invention is to provide to bite emulsifiable paste and synthetic method thereof.
For achieving the above object, the invention provides following technical scheme:
A kind of mosquito proof bites emulsifiable paste, comprises povidone iodine 3-10%, PEG-4000 30-50%, PEG-4000 3-25%, glycerol 3-8%, ethylparaben 0.1-0.5%, Oleum menthae 0.5-1.5%, Folium Artemisiae Argyi extracting solution 0.2-1%, lavandula angustifolia extracting solution 0.2-1%, vitamin E 0.1-1% and pure water 15-40% according to the raw material of mass percent.
As the further scheme of the present invention: comprise povidone iodine 3-5%, PEG-4000 40-45%, PEG-4000 20-25%, glycerol 5-8%, ethylparaben 0.1-0.2%, Oleum menthae 0.5-1.5%, Folium Artemisiae Argyi extracting solution 0.5-1%, lavandula angustifolia extracting solution 0.5-1%, vitamin E 0.1-0.5% and pure water 15-25% according to the raw material of mass percent.
Described mosquito proof bites the synthetic method of emulsifiable paste, and concrete steps are:
(1) after taking PEG-4000 in proportion, add in container A and be heated to 50-85 DEG C, until melt completely and stir, be incubated for subsequent use:
(2) in proportion water and glycerol are added in container B, under stirring, adding povidone iodine to dissolving completely in batches, being heated to 50-85 DEG C, being incubated for subsequent use;
(3) after taking PEG-4000 in proportion, add in container C and be heated to 50-85 DEG C, until melt completely and stir, be incubated for subsequent use;
(4) respectively solution in container C and container B is poured in container A under stirring, stir 5-20 minute;
(5) ethylparaben, Oleum menthae, Folium Artemisiae Argyi extracting solution, lavandula angustifolia extracting solution, vitamin E are added in container A, stir 5-20 minute, recording pH value is faintly acid in batches;
(6) under stirring, room temperature is cooled to, degassed, become cream.
Compared with prior art, the invention has the beneficial effects as follows: adopt Polyethylene Glycol as substrate, then be aided with the adjuvant of some anti-mosquito bite, the mosquito proof of having synthesized a kind of character stable bites emulsifiable paste; The method is simple and easy to do, product is stable, is applicable to suitability for industrialized production.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment 1
In the embodiment of the present invention, a kind of mosquito proof bites emulsifiable paste, comprises povidone iodine 4.39%, PEG-4000 43.88%, PEG-4000 21.94%, glycerol 5.7%, ethylparaben 0.17%, Oleum menthae 0.88%, Folium Artemisiae Argyi extracting solution 0.44%, lavandula angustifolia extracting solution 0.44%, vitamin E 0.22% and pure water 21.94% according to the raw material of mass percent.
Described mosquito proof bites the synthetic method of emulsifiable paste, and concrete steps are:
(1) after taking PEG-4000 in proportion, add in container A and be heated to 55 DEG C, until melt completely and stir, be incubated for subsequent use:
(2) in proportion water and glycerol are added in container B, under stirring, adding povidone iodine to dissolving completely in batches, being heated to 65 DEG C, being incubated for subsequent use;
(3) after taking PEG-4000 in proportion, add in container C and be heated to 65 DEG C, until melt completely and stir, be incubated for subsequent use;
(4) respectively solution in container C and container B is poured in container A under stirring, stir 10 minutes;
(5) ethylparaben, Oleum menthae, Folium Artemisiae Argyi extracting solution, lavandula angustifolia extracting solution, vitamin E are added in container A in batches, stir 10 minutes, recording pH value is faintly acid;
(6) under stirring, room temperature is cooled to, degassed, become cream.
Embodiment 2
In the embodiment of the present invention, a kind of mosquito proof bites emulsifiable paste, comprises povidone iodine 4.79%, PEG-4000 47.94%, PEG-4000 4.79%, glycerol 6.71%, ethylparaben 0.1%, Oleum menthae 0.96%, Folium Artemisiae Argyi extracting solution 0.48%, lavandula angustifolia extracting solution 0.48%, vitamin E 0.19% and pure water 33.56% according to the raw material of mass percent.
Described mosquito proof bites the synthetic method of emulsifiable paste, and concrete steps are:
(1) after taking PEG-4000 in proportion, add in container A and be heated to 65 DEG C, until melt completely and stir, be incubated for subsequent use:
(2) in proportion water and glycerol are added in container B, under stirring, adding povidone iodine to dissolving completely in batches, being heated to 55 DEG C, being incubated for subsequent use;
(3) after taking PEG-4000 in proportion, add in container C and be heated to 65 DEG C, until melt completely and stir, be incubated for subsequent use;
(4) respectively solution in container C and container B is poured in container A under stirring, stir 15 minutes;
(5) ethylparaben, Oleum menthae, Folium Artemisiae Argyi extracting solution, lavandula angustifolia extracting solution, vitamin E are added in container A in batches, stir 10 minutes, recording pH value is faintly acid;
(6) under stirring, room temperature is cooled to, degassed, become cream.
Embodiment 3
In the embodiment of the present invention, a kind of mosquito proof bites emulsifiable paste, comprises povidone iodine 7.5%, PEG-4000 34.5%, PEG-4000 18%, glycerol 6.8%, ethylparaben 0.3%, Oleum menthae 1.1%, Folium Artemisiae Argyi extracting solution 0.7%, lavandula angustifolia extracting solution 0.6%, vitamin E 0.5% and pure water 30% according to the raw material of mass percent.
Described mosquito proof bites the synthetic method of emulsifiable paste, and concrete steps are:
(1) after taking PEG-4000 in proportion, add in container A and be heated to 70 DEG C, until melt completely and stir, be incubated for subsequent use:
(2) in proportion water and glycerol are added in container B, under stirring, adding povidone iodine to dissolving completely in batches, being heated to 50 DEG C, being incubated for subsequent use;
(3) after taking PEG-4000 in proportion, add in container C and be heated to 65 DEG C, until melt completely and stir, be incubated for subsequent use;
(4) respectively solution in container C and container B is poured in container A under stirring, stir 8 minutes;
(5) ethylparaben, Oleum menthae, Folium Artemisiae Argyi extracting solution, lavandula angustifolia extracting solution, vitamin E are added in container A in batches, stir 10 minutes, recording pH value is faintly acid;
(6) under stirring, room temperature is cooled to, degassed, become cream.
In the embodiment of the present invention, the effect of each component is as follows: povidone iodine is a kind of well Cidex-7, to various bacteria, spore, virus, fungus etc., there is lethal effect, its mechanism of action is after povidone iodine touches affected part, can iodine be discharged and give play to bactericidal action, and little to tissue stimulation, be applicable to the treatment of skin, mucosa infection; Polyethylene Glycol is to no skin irritation and have lubricity, not easily oxidized; Oleum menthae obtains primarily of the fresh stem of Herba Menthae and Ye Jing vapor distillation, has the Herba Menthae fragrance of pure fragrance, pungent and refrigerant, has strong permeability of altering, and may be used for skin or mucosa produces refrigerant sense to alleviate pruritus pain; Stem and the Ye Jun of Folium Artemisiae Argyi have special odor, are that a kind of Chinese herbal medicine has medical value widely, and Folium Artemisiae Argyi extracting solution has repellent to fruit bat and mosquito, tags, fumigation action; Lavandula angustifolia is applicable to any skin, can promote cell regeneration, accelerating wound healing, have special effect to burn and scald, can anti-bacteria, reduces scar, pressure of releiving, lax neural, helps to fall asleep, removes nervous anxiety and have very good effect to driving away mosquito.Wherein the temperature that adds of povidone iodine is generally no more than 65 DEG C, and temperature is higher, and it is faster that iodine volatilizees, and povidone iodine content is also lower, and also has a certain impact to Folium Artemisiae Argyi extracting solution and lavandula angustifolia extracting solution active component.
The present invention adopts Polyethylene Glycol as substrate, then is aided with the adjuvant of some anti-mosquito bite, and the mosquito proof of having synthesized a kind of character stable bites emulsifiable paste; The method is simple and easy to do, product is stable, is applicable to suitability for industrialized production.
To those skilled in the art, obviously the invention is not restricted to the details of above-mentioned one exemplary embodiment, and when not deviating from spirit of the present invention or basic feature, the present invention can be realized in other specific forms.Therefore, no matter from which point, all should embodiment be regarded as exemplary, and be nonrestrictive, scope of the present invention is limited by claims instead of above-mentioned explanation, and all changes be therefore intended in the implication of the equivalency by dropping on claim and scope are included in the present invention.
In addition, be to be understood that, although this description is described according to embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should by description integrally, and the technical scheme in each embodiment also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.

Claims (3)

1. a mosquito proof bites emulsifiable paste, it is characterized in that, comprise povidone iodine 3-10%, PEG-4000 30-50%, PEG-4000 3-25%, glycerol 3-8%, ethylparaben 0.1-0.5%, Oleum menthae 0.5-1.5%, Folium Artemisiae Argyi extracting solution 0.2-1%, lavandula angustifolia extracting solution 0.2-1%, vitamin E 0.1-1% and pure water 15-40% according to the raw material of mass percent.
2. mosquito proof according to claim 1 bites emulsifiable paste, it is characterized in that, comprise povidone iodine 3-5%, PEG-4000 40-45%, PEG-4000 20-25%, glycerol 5-8%, ethylparaben 0.1-0.2%, Oleum menthae 0.5-1.5%, Folium Artemisiae Argyi extracting solution 0.5-1%, lavandula angustifolia extracting solution 0.5-1%, vitamin E 0.1-0.5% and pure water 15-25% according to the raw material of mass percent.
3. the mosquito proof as described in as arbitrary in claim 1-2 bites a synthetic method for emulsifiable paste, and it is characterized in that, concrete steps are:
(1) after taking PEG-4000 in proportion, add in container A and be heated to 50-85 DEG C, until melt completely and stir, be incubated for subsequent use:
(2) in proportion water and glycerol are added in container B, under stirring, adding povidone iodine to dissolving completely in batches, being heated to 50-85 DEG C, being incubated for subsequent use;
(3) after taking PEG-4000 in proportion, add in container C and be heated to 50-85 DEG C, until melt completely and stir, be incubated for subsequent use;
(4) respectively solution in container C and container B is poured in container A under stirring, stir 5-20 minute;
(5) ethylparaben, Oleum menthae, Folium Artemisiae Argyi extracting solution, lavandula angustifolia extracting solution, vitamin E are added in container A, stir 5-20 minute, recording pH value is faintly acid in batches;
(6) under stirring, room temperature is cooled to, degassed, become cream.
CN201410534069.2A 2014-10-12 2014-10-12 Mosquito bite prevention cream and synthesis method thereof Pending CN104257742A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201410534069.2A CN104257742A (en) 2014-10-12 2014-10-12 Mosquito bite prevention cream and synthesis method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410534069.2A CN104257742A (en) 2014-10-12 2014-10-12 Mosquito bite prevention cream and synthesis method thereof

Publications (1)

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CN104257742A true CN104257742A (en) 2015-01-07

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110038038A (en) * 2019-05-22 2019-07-23 浙江欧洁科技股份有限公司 A kind of refrigerant itch-relieving and sterilizing creams and preparation method thereof
WO2023119325A1 (en) * 2021-12-20 2023-06-29 Kejriwal Anil Molecular iodine and citronella oil based formulation, and its application as mosquito repellent

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101564049A (en) * 2008-04-24 2009-10-28 李宏智 Pure natural mosquito-repellent perfume and preparation method thereof
CN102349547A (en) * 2011-08-15 2012-02-15 湖南轻工研究院有限责任公司 Composite argy wormwood leaf low-alcohol mosquito-repellent liquid and preparation method thereof
CN103223010A (en) * 2013-05-13 2013-07-31 晋强 Preparation method of traditional Chinese medicine spray with anti-mosquito function

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101564049A (en) * 2008-04-24 2009-10-28 李宏智 Pure natural mosquito-repellent perfume and preparation method thereof
CN102349547A (en) * 2011-08-15 2012-02-15 湖南轻工研究院有限责任公司 Composite argy wormwood leaf low-alcohol mosquito-repellent liquid and preparation method thereof
CN103223010A (en) * 2013-05-13 2013-07-31 晋强 Preparation method of traditional Chinese medicine spray with anti-mosquito function

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
巴剑波，等。: "聚维酮碘特性及其制剂研究进展", 《中国消毒学杂志》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110038038A (en) * 2019-05-22 2019-07-23 浙江欧洁科技股份有限公司 A kind of refrigerant itch-relieving and sterilizing creams and preparation method thereof
WO2020233372A1 (en) * 2019-05-22 2020-11-26 浙江欧洁科技股份有限公司 Cooling and anti-itch antiseptic cream, and preparation method therefor
WO2023119325A1 (en) * 2021-12-20 2023-06-29 Kejriwal Anil Molecular iodine and citronella oil based formulation, and its application as mosquito repellent

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