CN104229188A - Gradient-method vacuumizing process and device for full-pressure-plug antibiotics bottle - Google Patents
Gradient-method vacuumizing process and device for full-pressure-plug antibiotics bottle Download PDFInfo
- Publication number
- CN104229188A CN104229188A CN201410430206.8A CN201410430206A CN104229188A CN 104229188 A CN104229188 A CN 104229188A CN 201410430206 A CN201410430206 A CN 201410430206A CN 104229188 A CN104229188 A CN 104229188A
- Authority
- CN
- China
- Prior art keywords
- plug
- bottle
- casing
- valve member
- plate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
The invention relates to a gradient-method vacuumizing process and device for a full-pressure-plug antibiotics bottle. The device comprises a hydraulic hoisting column, a box body, a pressing plate and a vacuum pipeline arranged on the box body, wherein the upper surface of the pressing plate is connected with the bottom of the hydraulic hoisting column and a bottle containing frame plate assembly with a buffering plate is arranged at the lower part; a front door with pneumatic hoisting is arranged on one side of the box body and a frame pushing rod is arranged on the opposite surface of the front door; an adjustable vacuum pipeline, a re-pressing pipeline and a washing and sterilizing device are arranged above the box body; the vacuum pipeline is provided with a valve piece I and a valve piece II which are parallel to each other; clean air is filtered by a filter and enters the box body from the re-pressing pipeline; powder is filled and the full-pressure-plug antibiotics bottles are sequentially arrayed and are arranged into the bottle containing frame plate assembly with the buffering plate; then the bottle containing frame plate assembly is pushed into the box body to be sealed; at the moment, the distance from the position of the pressing plate in the box body to a bottle plug is not more than 1.2 times the height of the plug. The gradient-method vacuumizing process adopts three times of vacuumizing, two times of plug pressing and two times of re-pressing so that the remaining oxygen of a powder injection type antibiotics bottled product is 3%-7%.
Description
Technical field
Patent of the present invention relates to a kind of total head plug antibiotic bottle gradient method evacuation process and device, be applicable to vacuumize after the total head such as cefotiam hydrochloridefor inj, cefmenoxime hydrochloride in powder-injection antibiotic bottle enters plug and ram compression plug production technology and device, can guarantee that powder pin class microbiotic bottled product remaining oxygen is 3% ~ 7%.
Background technology
Antibiotic bottle freeze-dried powder, powder pin belong to non-final sterilizing small-volume injection, and its equipment is a lot, but solely nothing is specifically designed to the equipment that total head plug antibiotic bottle vacuumizes.
At present, powder pin series products is produced and can be run into following problem in quality management and control: when (1) is containing buffering agent natrium carbonicum calcinatum, because there is CO when it dissolves
2, therefore have in air-tight bottle and make negative pressure requirements; (2) oxidizing medicine, it there are certain requirements the remaining oxygen of air-tight bottle.For guaranteeing drug safety and validity, often process need be vacuumized to this series products.
Existing vacuum pumping can use soil to be shaped with in machine glass case and vacuumize process, and it all completes in B level region, and speed is slow, and labour intensity is large, and organism glass box can not sterilization treatment.New edition GMP(2010) regulation promulgate after; allly relate to the administrative measure that the product showing sterility test project in legal medicine standard is all included into sterile production; arrive like this non-final sterilising prods all need under B level background A level regional production; this just needs to abandon manual mode of operation; utilize Sealing Arrangement to produce under the protection of A level laminar flow, and equipment can conveniently clean and sterilizing.
Summary of the invention
The object of the invention is to provide a kind of device vacuumized for total head plug antibiotic bottle gradient method, is applicable to vacuumize after the total head such as cefotiam hydrochloridefor inj, cefmenoxime hydrochloride in powder-injection antibiotic bottle enters plug and ram compression plug production technology.
Still a further object of the present invention is the evacuation process providing a kind of device using above-mentioned total head plug antibiotic bottle gradient method to vacuumize, and guarantees that powder pin class microbiotic bottled product remaining oxygen is 3% ~ 7%.
Another object of the present invention is to cleaning and sterilizing methods that the above-mentioned anti-total head plug device that raw plain bottle gradient method vacuumizes is provided.
Another object of the present invention is that taking out very of the device providing above-mentioned total head plug antibiotic bottle gradient method to vacuumize can the method for effective tamponade.
The object of the invention is achieved through the following technical solutions: a kind of device vacuumized for total head plug antibiotic bottle gradient method; what be located at powder-injection racking machine delivery track goes out end; be distributed into powder and total head plug antibiotic bottle A level laminar flow protection under; pass through delivery track; in the device that feeding gradient method vacuumizes; the device that described gradient method vacuumizes comprises hydraulic lifting post, casing, pressing plate, is located at vacuum line on casing and the pump housing, wherein:
Described pressing plate upper surface is connected with the bottom of hydraulic lifting post, energy oscilaltion, and below arranges the Sheng bottle deckle board assembly of a band dash plate, and this Sheng bottle deckle board assembly is supported by case internal support plate;
Described casing side is provided with Qianmen, be provided with the Qianmen opposite face of band Pneumatic elevation and push away frame bar, adjustable vacuum line is provided with and with the multiple pressure pipe road of filter, valve member five and cleaning, bactericidal unit, described vacuum line is provided with valve member one in parallel and valve member two above casing;
The described multiple pressure pipe road other end is positioned at B level clean area, now pure air by metre filter laggard enter casing;
Be distributed into powder and total head plug antibiotic bottle by ordered arrangement and be inserted in band dash plate Sheng bottle deckle board assembly in, push in casing through pushing away frame bar, descending to the Pneumatic elevation door-opening mechanism on Qianmen, complete and close the door and seal, now, the position of the pressing plate in casing is for high for being not more than 1.2 times of plugs from bottle stopper distance.
Antibiotic bottle after total head plug can vacuumize and ram compression plug by apparatus of the present invention, reaches medicine place vacuum shape in bottle, and vacuum all under the protection of A level laminar flow Sealing Arrangement carry out.The present invention has opened up powder-injection production facilities.
Wherein, the bar portion of hydraulic lifting post available corrugated stainless steel tubing protection in case.Described casing can adopt square pressure resistant vessel etc.Described pushes away frame bar outside casing, and bar portion is in casing, and the available corrugated stainless steel tubing protection in bar portion.Described case internal support plate 7: on the bottom in casing 2, its top is dull and stereotyped, under have supporting base.
Described be distributed into powder and total head plug antibiotic bottle also can under mechanical device effect permutation being inserted in the Sheng bottle deckle board assembly of band dash plate, pushed in casing by manipulator.
On such scheme basis, the Sheng bottle deckle board assembly of described band dash plate also comprises band hole slot lower frame plate, the spring fixed seat being located at hole slot inner bottom part and the spring be enclosed within spring fixed seat, the bottom of the pin that spring supporting is connected with dash plate through screw.
On such scheme basis, described closing the door and seal is realized by the inflation of gas-flow closure bar.
On such scheme basis, described cleaning, bactericidal unit form washing equipment by the outlet pipeline of the spray ball in the adjustable vacuum line be located at above casing, the band water for injection pipeline of valve member four, casing and the band foul valve that is connected with the pump housing below casing; Bactericidal unit is formed by the pure steam line of band valve member three.
On such scheme basis, described foul valve is made up of valve body nine and/or series connection one check valve.
On such scheme basis, before and after the described pump housing, set up valve body six and valve body seven separately.
The invention provides the evacuation process of the device that a kind of above-mentioned total head plug antibiotic bottle gradient method vacuumizes, comprise the steps, comprising:
Vacuumize for 1st time, in vacuum line, open valve member two and Shut-off fitting one, start to vacuumize, casing internal pressure is 0.02MPa, the time is 1min, now, in Sheng bottle deckle board assembly, total head plug antibiotic bottle under vacuum, plays plug, namely plug is transferred to, rise in plug process and locate by dash plate, containing multiple row antibiotic bottle plug in bottle deckle board assembly has concertedness to play plug, is pulled out to most of plug and does not all transfer to bottleneck;
Vacuumize for 2nd time, in vacuum line, open valve member one and Shut-off fitting two, start to continue to vacuumize, casing internal pressure is 0.04MPa, the time is 1min, now, in Sheng bottle deckle board assembly, capping plug antibiotic bottle is under continuation vacuum action, continued plug, risen in the process of plug and located by dash plate Gravitative Loads, the antibiotic bottle plug in Sheng bottle deckle board assembly is all by dial-out bottleneck;
Vacuumize for 3rd time, in vacuum line, valve member one and two is opened, and starts to continue to vacuumize, casing internal pressure is 0.06MPa, the time is 1min, in Sheng bottle deckle board assembly, capping plug antibiotic bottle is under continuation vacuum action, and the air in bottle is pumped, when vacuumizing, by the drag effect of dash plate B2 gravity, plug no longer continues to rise, and dash plate surface of fitting, after 1min, valve member one and two is closed simultaneously;
1st tamponade, hydraulic lifting cornice dynamic pressure plate is descending, in descending process, press against dash plate descending, dash plate is descending press against plug, is pressed into by plug in microbiotic bottleneck, due to the buffer action of dash plate lower spring, plug is not all pressed in major part press-in microbiotic bottleneck;
1st multiple pressure, in multiple pressure pipe road, valve member five is opened, and the multiple pressure pipe road other end is positioned at B level clean area, and now pure air is by after metre filter, and enter in casing, when reaching 0.04 MPa to case internal pressure, valve member five is closed;
2nd tamponade, hydraulic lifting cornice dynamic pressure plate continue descending, in descending process, press against dash plate descending while, dash plate is descending press against plug, and plug is all pressed in microbiotic bottleneck;
2nd multiple pressure, in multiple pressure pipe road, valve member five is opened again, and the multiple pressure pipe road other end is positioned at B level clean area, and now pure air is by after metre filter, and enter in casing, when reaching 0.1MPa to case internal pressure, valve member five is closed;
Pressing plate resets, and hydraulic lifting cornice dynamic pressure plate is up, makes it arrive raw bits, and meanwhile, dash plate (B2) resets under the action of the spring;
Enabling discharging, the gas-flow closure bar venting on Qianmen, Pneumatic elevation door-opening mechanism is up, completes enabling, is pushing away under the effect of frame bar, having exhausted vacuum and antibiotic bottle after tamponade, releasing casing containing in bottle deckle board assembly;
With this production that circulated.
The invention provides the method for cleaning of the device that a kind of above-mentioned total head plug antibiotic bottle gradient method vacuumizes, in the steps below sequentially:
Casing cleans after closing door sealing, comprising:
1) slightly wash, open the valve member four on water for injection pipeline, enter spray ball to casing 2 interior flushing with 70 DEG C of waters for injection, hydraulic pressure 0.25MPa, time 5min, Shut-off fitting four, the valve member nine of performing fighting in outlet pipeline, Shut-off fitting nine after effluent sewerage;
2) soak, again open the valve member four on water for injection pipeline, after entering spray ball with 70 DEG C of waters for injection, casing 2 inside is discharged water, hydraulic pressure 0.25MPa, discharge water 15min, Shut-off fitting four, with water to box house heavy bubble 25min, opens the valve member six in outlet pipeline, open outlet pipeline middle pump body and valve member seven, sewage is discharged fast;
3) rinsing, again opens valve member four pairs of box houses on water for injection pipeline and rinses, hydraulic pressure 0.25MPa, time 5min, Shut-off fitting four, the foul valve valve member nine of performing fighting in outlet pipeline, Shut-off fitting nine after discharging water.
The sterilizing of the device that the present invention also provides a kind of above-mentioned total head plug antibiotic bottle gradient method to vacuumize and drying means, in the steps below sequentially:
1) open valve member one or two in vacuum line, Shut-off fitting one or two after 1 vacuum 3min is taken out to casing;
2) valve member three in pure steam line is opened, with pure steam to casing sterilizing, in pressure 1.06 MPa, temperature 122 DEG C, time 30min sterilizing;
3) dry, after sterilizing, the foul valve of performing fighting in outlet pipeline, closes foul valve after discharge condensed water, opens valve member one or two in vacuum line, take out secondary vacuum to casing, each time 3min, then Shut-off fitting one or two.
Advantage of the present invention is: by gradient method evacuation process; namely while " vacuumize for 3 times, 2 tamponades, 2 multiple pressures " technique; rely on contain bottle deckle board assembly to antibiotic bottle after whole frame total head plug vacuumizing, balance and the collaborative effect of tamponade process; antibiotic bottle after total head plug can be vacuumized and ram compression plug; reach medicine place vacuum shape in bottle; and vacuum all A level laminar flow protection under Sealing Arrangement carry out, guarantee that similar cefotiam hydrochloridefor inj, cefmenoxime hydrochloride in powder-injection bottled product remaining oxygen are at 3%-7%.
Accompanying drawing explanation
Fig. 1 structure of the present invention and pipeline schematic diagram;
Fig. 2 the present invention contains a bottle schematic front view for deckle board assembly 5;
Fig. 3 the present invention contains the partial schematic sectional view of A-A in bottle deckle board assembly 5;
Fig. 4 the present invention contains schematic top plan view in bottle deckle board assembly 5;
Fig. 5 is present invention process diagram of circuit.
In Fig. 1:
1---hydraulic lifting post; 2---casing;
3---spray head; 4---pressing plate;
5---contain bottle deckle board assembly;
6---push away frame bar; 7---back plate;
8---the pump housing; 9---Qianmen;
10---filter;
G1---vacuum line; G2---pure steam line;
G3---water for injection pipeline; G4---multiple pressure pipe road;
G5---outlet pipeline;
In Fig. 2 to 4:
5---contain bottle deckle board assembly:
B2---dash plate, B1---screw, B3---pin, B4---band hole slot lower frame plate, B5---spring, B6---spring perch.
Detailed description of the invention
Shown in structure as of the present invention in Fig. 1 and pipeline schematic diagram, a kind of device vacuumized for total head plug antibiotic bottle gradient method, what be located at powder-injection racking machine delivery track goes out end, be distributed into powder and total head plug antibiotic bottle A level laminar flow protection under, pass through delivery track, in the device that feeding gradient method vacuumizes, or, permutation under mechanical device effect is also inserted in the Sheng bottle deckle board assembly of band dash plate, in the device vacuumized by manipulator feeding gradient method, the device that described gradient method vacuumizes comprises hydraulic lifting post 1, casing 2, pressing plate 4, be located at the vacuum line G1 on casing 2 and the pump housing 8, wherein:
Be connected with the bottom of hydraulic lifting post 1 at described pressing plate 4 upper surface, below arranges the Sheng bottle deckle board assembly 5 of a band dash plate B2, and this Sheng bottle deckle board assembly 5 is supported by case internal support plate 7;
Described casing 2 side is provided with Qianmen 9, be provided with Qianmen 9 opposite face of band Pneumatic elevation and push away frame bar 6, adjustable vacuum line G1 is provided with and with the multiple pressure pipe road G4 of filter 10, valve member five F5 and cleaning, bactericidal unit, described vacuum line G1 is provided with valve member one F1 in parallel and valve member two F2 above casing 2;
The described multiple pressure pipe road G4 other end is positioned at B level clean area, now pure air by filter 10 filter laggard enter casing 2;
Be distributed into powder and total head plug antibiotic bottle is inserted in the Sheng bottle deckle board assembly 5 of band dash plate B2 by ordered arrangement, push in casing 2 through pushing away frame bar 6, descending to the Pneumatic elevation door-opening mechanism on Qianmen 9, complete and close the door and seal, now, the position of the pressing plate 4 in casing 2 is for doubly filling in high from bottle stopper distance for 1.1-1.2.
As Fig. 2 the present invention contains a bottle schematic front view for deckle board assembly 5, Fig. 3 the present invention contains A-A in bottle deckle board assembly 5 partial schematic sectional view and Fig. 4 the present invention to contain in bottle deckle board assembly 5 shown in schematic top plan view: as described in the Sheng bottle deckle board assembly 5 of band dash plate B2 also comprise lower frame plate B4 with holes, be located at the spring fixed seat B6 of groove inner bottom part and be enclosed within the spring B 5 on spring fixed seat B6, spring B 5 supports the bottom of the pin B3 be connected with dash plate B2 through screw B1.In the present embodiment, dash plate B2 is evenly equipped with 20 screw B1 and pin B3, its composition is contained the upper part of bottle deckle board assembly 5; Trough of belt lower frame plate B4 makes frame by stainless steel square steel, frame surrounding has 20 holes, assembles upper spring B5 and spring perch B6 in hole, and its composition is contained bottle deckle board assembly 5 lower part, hole is corresponding with the position of pin, Sheng bottle deckle board assembly 5 upper part can be inserted and contain bottle deckle board assembly 5 lower part.
In the present embodiment, described Qianmen 9 is located at before casing 2, and it is made up of gas-flow closure bar, Pneumatic elevation door-opening mechanism.
Described vacuum line G1: be made up of pipeline, valve member F1/F2, it is placed in above casing 2.
Described pure steam line G2: be made up of pipeline, valve member F3, it is placed in above casing 2.
Described water for injection pipeline G3: be made up of pipeline, valve member F4, it is placed in above casing 2.
Described multiple pressure pipe road G4: be made up of pipeline, valve member F5, filter 10, it is placed in above casing 2, and filter 10 outlet is in B level clean area.
Described outlet pipeline G5: be made up of pipeline, valve member F6/F7/F9, check valve F8, water pump 8, it is placed in bottom casing 2.
As shown in Figure 5: be " vacuumize for 3 times, 2 tamponades, 2 multiple pressures ", step is as follows:
Vacuumize for 1st time, in vacuum line G1, open valve member two F2 and Shut-off fitting one F1, start to vacuumize, casing internal pressure is 0.02MPa, the time is 1min, now, in Sheng bottle deckle board assembly 5, total head plug antibiotic bottle under vacuum, plays plug, namely plug is transferred to, play by the effect of dash plate B2 detent force in plug process, containing multiple row antibiotic bottle plug in bottle deckle board assembly 5 has concertedness to play plug, is pulled out to most of plug and does not all transfer to bottleneck;
Vacuumize for 2nd time, in vacuum line G1, open valve member one F1 and Shut-off fitting two F2, start to continue to vacuumize, casing internal pressure is 0.04MPa, the time is 1min, now, in Sheng bottle deckle board assembly 5, capping plug antibiotic bottle is under continuation vacuum action, continued plug, risen in the process of plug and located by dash plate B2 Gravitative Loads, the antibiotic bottle plug in Sheng bottle deckle board assembly 5 is all by dial-out bottleneck;
Vacuumize for 3rd time, in vacuum line G1, valve member one and two F1/ F2 opens, and starts to continue to vacuumize, casing internal pressure is 0.06MPa, the time is 1min, in Sheng bottle deckle board assembly 5, capping plug antibiotic bottle is under continuation vacuum action, and the air in bottle is pumped, when vacuumizing, by the drag effect of dash plate B2 gravity, plug no longer continues to rise, and dash plate B2 surface of fitting, after 1min, valve member one and two F1, F2 close simultaneously;
1st tamponade, hydraulic lifting post 1 is with dynamic pressure plate 4 descending, in descending process, press against dash plate B1 descending, dash plate B2 is descending press against plug, be pressed into by plug in microbiotic bottleneck, due to the buffer action of dash plate B2 lower spring B5, plug is not all pressed in major part press-in microbiotic bottleneck;
1st multiple pressure, in multiple pressure pipe road G4, valve member five F5 opens, and the multiple pressure pipe road G4 other end is positioned at B level clean area, and after now pure air is filtered by filter 10, enter in casing 2, when reaching 0.04 MPa to case internal pressure, valve member five F5 closes;
2nd tamponade, it is descending that hydraulic lifting post 1 is with dynamic pressure plate 4 to continue, in descending process, press against dash plate B2 descending while, dash plate B2 is descending press against plug, and plug is all pressed in microbiotic bottleneck;
2nd multiple pressure, in multiple pressure pipe road G4, valve member five F5 opens again, and the multiple pressure pipe road G4 other end is positioned at B level clean area, and after now pure air is filtered by filter 10, enter in casing 2, when reaching 0.1MPa to case internal pressure, valve member five F5 closes;
Pressing plate resets, and hydraulic lifting post 1 is with dynamic pressure plate 4 up, makes it arrive raw bits, and meanwhile, dash plate B2 resets under spring B 5 acts on;
Enabling discharging, the gas-flow closure bar venting on Qianmen 9, Pneumatic elevation door-opening mechanism is up, completes enabling, is pushing away under frame bar 6 acts on, and having exhausted vacuum and antibiotic bottle after tamponade, releasing casing containing in bottle deckle board assembly 5;
With this production that circulated.
Cleaning, sterilizing, drying means:
Casing 2 cleans after closing door sealing, comprising:
1) slightly wash, open valve member four F4 on water for injection pipeline G3, enter spray ball 3 pairs of casing 2 interior flushings with 70 DEG C of waters for injection, hydraulic pressure 0.25MPa, time 5min, Shut-off fitting four F4, valve member nine F9 performed fighting in outlet pipeline G5, Shut-off fitting nine F9 after effluent sewerage;
2) soak, again open valve member four F4 on water for injection pipeline G3, after entering spray ball 3 with 70 DEG C of waters for injection, casing 2 inside is discharged water, hydraulic pressure 0.25MPa, discharge water 15min, Shut-off fitting four F4, with water to casing 2 inside heavy bubble 25min, opens valve member six F6 in outlet pipeline G5, open outlet pipeline G5 middle pump body 8 and valve member seven F7, sewage is discharged fast;
3) rinsing, to open on water for injection pipeline G3 valve member four F4 again to casing 2 interior flushing, hydraulic pressure 0.25MPa, time 5min, Shut-off fitting four F4, foul valve valve member nine F9 performed fighting in outlet pipeline G5, Shut-off fitting nine F9 after discharging water.
Sterilizing and drying means:
1) open valve member one or two F1 or F2 in vacuum line G1, Shut-off fitting one or two F1 or F2 after 1 vacuum 3min is taken out to casing 2;
2) valve member three F3 in pure steam line G2 is opened, with pure steam to casing 2 sterilizing, in pressure 1.06 MPa, temperature 122 DEG C, time 30min sterilizing;
3) dry, after sterilizing, the foul valve F9 performed fighting in outlet pipeline G5, closes foul valve after discharge condensed water, opens valve member two F2 in vacuum line G1, take out secondary vacuum to casing 2, each time 3min, then Shut-off fitting two F2.
it is emphasized that: be the better implementation column of the present invention above, not any type of restriction is substantially done to the present invention, every do according to present invention process and above embodiment any simple modification, equivalent variations and modification, still belong in scope of the present invention.
Claims (9)
1. the device vacuumized for total head plug antibiotic bottle gradient method; what be located at powder-injection racking machine delivery track goes out end; be distributed into powder and total head plug antibiotic bottle A level laminar flow protection under; pass through delivery track; send in the device that gradient method vacuumizes under mechanical device effect; it is characterized in that: the device that described gradient method vacuumizes comprises hydraulic lifting post (1), casing (2), pressing plate (4), is located at vacuum line (G1) on casing (2) and the pump housing (8), wherein:
Be connected with the bottom of hydraulic lifting post (1) at described pressing plate (4) upper surface, below arranges Sheng bottle deckle board assembly (5) of a band dash plate (B2), and this Sheng bottle deckle board assembly (5) is supported by case internal support plate (7);
Described casing (2) side is provided with Qianmen (9), be provided with Qianmen (9) opposite face of band Pneumatic elevation and push away frame bar (6), casing (2) top be provided with adjustable vacuum line (G1) and with filter (10), valve member five (F5) multiple pressure pipe road (G4) and cleaning, bactericidal unit, described vacuum line (G1) be provided with parallel connection valve member one (F1) and valve member two (F2);
Described multiple pressure pipe road (G4) other end is positioned at B level clean area, now pure air by filter (10) filter laggard enter casing (2);
Be distributed into powder and total head plug antibiotic bottle by ordered arrangement and be inserted in band dash plate (B1) Sheng bottle deckle board assembly 5 in, push in casing (2) through pushing away frame bar (6), descending to the Pneumatic elevation door-opening mechanism on Qianmen (9), complete and close the door and seal, now, the position of the pressing plate (4) in casing (2) is for high for being not more than 1.2 times of plugs from bottle stopper distance.
2. the device vacuumized for total head plug antibiotic bottle gradient method according to claim 1, it is characterized in that: Sheng bottle deckle board assembly (5) of described band dash plate (B2) also comprises lower frame plate with holes (B4), is located at the spring fixed seat (B6) of hole inner bottom part and is enclosed within the spring (B5) on spring fixed seat (B6), spring (B5) supports the bottom of the pin (B3) be connected with dash plate (B2) through screw (B1).
3. the device vacuumized for total head plug antibiotic bottle gradient method according to claim 1, is characterized in that: described closing the door and seal is realized by the inflation of gas-flow closure bar.
4. the device vacuumized for total head plug antibiotic bottle gradient method according to claim 1, is characterized in that: described cleaning, bactericidal unit form washing equipment by the outlet pipeline (G5) being located at the adjustable vacuum line (G1) of casing (2) top, the water for injection pipeline (G3) of band valve member four (F4), the spray ball (3) in casing (2) and being connected with the band foul valve of the pump housing (8) in casing (2) below; Bactericidal unit is formed by the pure steam line (G2) of band valve member three (F3).
5. the device vacuumized for total head plug antibiotic bottle gradient method according to claim 4, is characterized in that: described foul valve series connection valve body nine (F9) and/or series connection one check valve (F8) composition.
6. the device vacuumized for total head plug antibiotic bottle gradient method according to claim 4, is characterized in that: set up valve body six (F6) and valve body seven (F7) separately before and after the described pump housing (8).
7. the evacuation process of the device that total head plug antibiotic bottle gradient method vacuumizes according to any one of claims 1 to 3, comprises the steps, comprising:
Vacuumize for 1st time, in vacuum line (G1), open valve member two (F2) and Shut-off fitting one (F1), start to vacuumize, casing internal pressure is 0.02MPa, the time is 1min, now, in Sheng bottle deckle board assembly (5), total head plug antibiotic bottle under vacuum, play plug, namely plug is transferred to, play by the effect of dash plate (B2) detent force in plug process, containing bottle deckle board assembly (5) interior multiple row antibiotic bottle plug has concertedness to play plug, is pulled out to most of plug and does not all transfer to bottleneck;
Vacuumize for 2nd time, in vacuum line (G1), open valve member one (F1) and Shut-off fitting two (F2), start to continue to vacuumize, casing internal pressure is 0.04MPa, the time is 1min, now, in Sheng bottle deckle board assembly (5), capping plug antibiotic bottle is under continuation vacuum action, continued plug, risen in the process of plug and located by dash plate (B2) Gravitative Loads, the antibiotic bottle plug in Sheng bottle deckle board assembly (5) is all by dial-out bottleneck;
Vacuumize for 3rd time, in vacuum line (G1), valve member one and two F1/ F2 opens, and starts to continue to vacuumize, casing internal pressure is 0.06MPa, the time is 1min, in Sheng bottle deckle board assembly (5), capping plug antibiotic bottle is under continuation vacuum action, and the air in bottle is pumped, when vacuumizing, by the drag effect of dash plate B2 gravity, plug no longer continues to rise, and dash plate of fitting (B2) is surperficial, and after 1min, valve member one and two (F1, F2) is closed simultaneously;
1st tamponade, hydraulic lifting post (1) band dynamic pressure plate (4) is descending, in descending process, press against dash plate (B1) descending, dash plate (B2) is descending press against plug, be pressed into by plug in microbiotic bottleneck, due to the buffer action of dash plate (B2) lower spring B5, plug is not all pressed in major part press-in microbiotic bottleneck;
1st multiple pressure, in multiple pressure pipe road (G4), valve member five (F5) is opened, multiple pressure pipe road (G4) other end is positioned at B level clean area, after now pure air is filtered by filter (10), enters in casing (2), when reaching 0.04 MPa to case internal pressure, valve member five F5 closes;
2nd tamponade, hydraulic lifting post (1) band dynamic pressure plate 4 continue descending, in descending process, press against dash plate (B2) descending while, dash plate (B2) is descending press against plug, and plug is all pressed in microbiotic bottleneck;
2nd multiple pressure, in multiple pressure pipe road (G4), valve member five (F5) is opened again, multiple pressure pipe road (G4) other end is positioned at B level clean area, after now pure air is filtered by filter (10), enters in casing (2), when reaching 0.1MPa to case internal pressure, valve member five (F5) is closed;
Pressing plate resets, and hydraulic lifting post (1) band dynamic pressure plate (4) is up, makes it arrive raw bits, and meanwhile, dash plate (B2) resets under spring (B5) effect;
Enabling discharging, the gas-flow closure bar venting on Qianmen (9), Pneumatic elevation door-opening mechanism is up, completes enabling, is pushing away under frame bar (6) effect, has exhausted vacuum and antibiotic bottle after tamponade, release casing containing in bottle deckle board assembly (5);
With this production that circulated.
8. the method for cleaning of the device vacuumized according to one of claim 4 to 6 described total head plug antibiotic bottle gradient method, its feature exists, in the steps below sequentially:
Casing (2) cleans after closing door sealing, comprising:
1) slightly wash, open the valve member four (F4) on water for injection pipeline (G3), spray ball (3) is entered to casing 2 interior flushing with 70 DEG C of waters for injection, hydraulic pressure 0.25MPa, time 5min, Shut-off fitting four (F4), the valve member nine (F9) of performing fighting in outlet pipeline (G5), Shut-off fitting nine (F9) after effluent sewerage;
2) soak, again open the valve member four (F4) on water for injection pipeline (G3), after entering spray ball (3) with 70 DEG C of waters for injection, casing 2 inside is discharged water, hydraulic pressure 0.25MPa, discharge water 15min, Shut-off fitting four (F4), with water to casing (2) inside heavy bubble 25min, opens the valve member six (F6) in outlet pipeline (G5), open outlet pipeline (G5) middle pump body (8) and valve member seven (F7), sewage is discharged fast;
3) rinsing, again open the upper valve member four (F4) of water for injection pipeline (G3) to casing (2) interior flushing, hydraulic pressure 0.25MPa, time 5min, Shut-off fitting four (F4), the foul valve valve member nine (F9) of performing fighting in outlet pipeline (G5), Shut-off fitting nine (F9) after discharging water.
9. the sterilizing of the device vacuumized according to one of claim 4 to 6 described total head plug antibiotic bottle gradient method and drying means, its feature exists, in the steps below sequentially:
1) open valve member one or two (F1 or F2) in vacuum line (G1), Shut-off fitting one or two (F1 or F2) after 1 vacuum 3min is taken out to casing (2);
2) valve member three (F3) in pure steam line (G2) is opened, with pure steam to casing (2) sterilizing, in pressure 1.06 MPa, temperature 122 DEG C, time 30min sterilizing;
3) dry, after sterilizing, the foul valve in outlet pipeline of performing fighting (G5), closes foul valve after discharge condensed water, opens valve member two (F2) in vacuum line (G1), take out secondary vacuum, each time 3min, then Shut-off fitting two (F2) to casing (2).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410430206.8A CN104229188B (en) | 2014-08-28 | 2014-08-28 | A kind of total head plug antibiotic bottle gradient method evacuation process and device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410430206.8A CN104229188B (en) | 2014-08-28 | 2014-08-28 | A kind of total head plug antibiotic bottle gradient method evacuation process and device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104229188A true CN104229188A (en) | 2014-12-24 |
| CN104229188B CN104229188B (en) | 2016-08-17 |
Family
ID=52218266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410430206.8A Active CN104229188B (en) | 2014-08-28 | 2014-08-28 | A kind of total head plug antibiotic bottle gradient method evacuation process and device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104229188B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106672441A (en) * | 2017-01-23 | 2017-05-17 | 浙江丽生生物科技有限公司 | DNA specimen normal temperature preservation preparation method and packaging equipment |
| CN108653760A (en) * | 2018-05-29 | 2018-10-16 | 尹兴政 | A kind of medical bottle tool steam sterilization system convenient for drying |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001088898A (en) * | 1999-09-16 | 2001-04-03 | Hisaka Works Ltd | Plug sealing device for container |
| JP2008188898A (en) * | 2007-02-06 | 2008-08-21 | Konica Minolta Holdings Inc | Recorder |
| WO2012016301A1 (en) * | 2010-08-06 | 2012-02-09 | Hospira Australia Pty Ltd | Vial preparation method and system |
| CN102838063A (en) * | 2012-09-29 | 2012-12-26 | 山东淄博民康药业包装有限公司 | Pre-encapsulating glass syringe vacuum plugging method |
| CN203172916U (en) * | 2013-04-16 | 2013-09-04 | 楚天科技股份有限公司 | Vacuumizing nitrogen-charging stoppering assembly |
| CN203794581U (en) * | 2014-04-04 | 2014-08-27 | 上海都能制药机械设备有限公司 | Vacuum box plugging device |
-
2014
- 2014-08-28 CN CN201410430206.8A patent/CN104229188B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001088898A (en) * | 1999-09-16 | 2001-04-03 | Hisaka Works Ltd | Plug sealing device for container |
| JP2008188898A (en) * | 2007-02-06 | 2008-08-21 | Konica Minolta Holdings Inc | Recorder |
| WO2012016301A1 (en) * | 2010-08-06 | 2012-02-09 | Hospira Australia Pty Ltd | Vial preparation method and system |
| CN102838063A (en) * | 2012-09-29 | 2012-12-26 | 山东淄博民康药业包装有限公司 | Pre-encapsulating glass syringe vacuum plugging method |
| CN203172916U (en) * | 2013-04-16 | 2013-09-04 | 楚天科技股份有限公司 | Vacuumizing nitrogen-charging stoppering assembly |
| CN203794581U (en) * | 2014-04-04 | 2014-08-27 | 上海都能制药机械设备有限公司 | Vacuum box plugging device |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106672441A (en) * | 2017-01-23 | 2017-05-17 | 浙江丽生生物科技有限公司 | DNA specimen normal temperature preservation preparation method and packaging equipment |
| CN108653760A (en) * | 2018-05-29 | 2018-10-16 | 尹兴政 | A kind of medical bottle tool steam sterilization system convenient for drying |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104229188B (en) | 2016-08-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE102014116463A1 (en) | Apparatus and method for filling a container with a carbonated filling product | |
| CN104229188A (en) | Gradient-method vacuumizing process and device for full-pressure-plug antibiotics bottle | |
| CN103100125B (en) | Air non-return pressure relief device | |
| CN203609680U (en) | Dental handpiece cleaning machine | |
| CN203417350U (en) | Steam disinfector | |
| CN105158052B (en) | A kind of efficient process equipment of fluid sample | |
| JP5998539B2 (en) | Cleaning and filling equipment | |
| CN104757341A (en) | Vacuum ozone sterilizer | |
| ES2439040T3 (en) | Filling machine and procedure for disinfecting said filling machine | |
| CN212090310U (en) | Ozone disinfection and sterilization device | |
| CN104001198B (en) | A kind of sterilizing methods and dual chamber multilamellar hydrogen peroxide sterilization machine | |
| CN204016915U (en) | Disinfectant solution gas is resolved exhaust system | |
| CN102961769A (en) | Sealing ring of steam sterilizer | |
| CN107540052B (en) | Soft water treatment system containing disinfection device | |
| CN208710565U (en) | A kind of workshop modular decontamination system | |
| CN110974991A (en) | Low-concentration formaldehyde sterilization system and use method thereof | |
| CN213666881U (en) | Make things convenient for newborn feeding bottle disinfect box for paediatrics | |
| CN204798423U (en) | Protected against explosion medical disinfection machine | |
| CN207531585U (en) | A kind of Minitype seed tissue culture chlorination equipment | |
| CN214110478U (en) | Aseptic operation panel of pneumonia vaccine processing | |
| CN205163699U (en) | Disinfection and isolation case | |
| CN203263865U (en) | Multifunctional sterilization drying cabinet | |
| CN215740626U (en) | Automatic control steam sterilization device | |
| CN204180854U (en) | A kind of bundle hoof high temperature sterilizing device of improvement | |
| CN216709855U (en) | Continuous disinfection device for dairy product production line |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: 201209 Chuansha Road, Shanghai, No. 978, No. Applicant after: SHANGHAI PHARMA NEW ASIA PHARMACEUTICAL CO., LTD. Address before: 201209 Chuansha Road, Shanghai, No. 978, No. Applicant before: Shanghai Xinya Pharmaceutical Industry Co., Ltd. |
|
| COR | Change of bibliographic data | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |