CN104226168B - A kind of magnetic bead reagent evenly mixing device - Google Patents
A kind of magnetic bead reagent evenly mixing device Download PDFInfo
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- CN104226168B CN104226168B CN201410524578.7A CN201410524578A CN104226168B CN 104226168 B CN104226168 B CN 104226168B CN 201410524578 A CN201410524578 A CN 201410524578A CN 104226168 B CN104226168 B CN 104226168B
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- gear
- bottle holder
- magnetic bead
- bead reagent
- synchronous pulley
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Abstract
The invention provides a kind of magnetic bead reagent evenly mixing device, including power part, the first mixing portion and the second mixing portion.Power part includes motor, the small synchronous pulley being connected with motor and the big synchronous pulley being connected by Timing Belt with small synchronous pulley.First mixing portion includes rotating disk and the first gear wheel being connected respectively with big synchronous pulley, the first little gear being positioned on rotating disk and the little bottle holder being positioned on little gear.Second mixing portion includes the second largest gear being connected with big synchronous pulley bottom, the two pinion engaged with second largest gear, with two pinion bottom meshed gears B and gear B meshed gears A and the big bottle holder that is positioned in gear A.The beneficial effect of the invention it is possible to the disposable quickly multiple magnetic bead reagent of mixing, and mixing result has high concordance simultaneously, is especially suitable for the mixing of magnetic bead reagent in chemiluminescence immune assay.
Description
Technical field
The invention belongs to chemiluminescence immune assay apparatus field, especially relates to a kind of magnetic bead reagent
Evenly mixing device.
Background technology
Luminescence immunoassay is the novel ultra micro of one that luminesceence analysis and immunoreation are combined and set up
Component analysis technology.This technology utilizes chemistry or bio-luminescence system as the instruction system of antigen antibody reaction
System, so as to detection by quantitative antigen or the method for antibody.This method is with the high sensitivity of luminesceence analysis
High degree of specificity with antigen antibody reaction.
Magnetic particle type Full-automatic chemiluminescence analyser needs to use magnetic bead turbid solution during test
Reagent, magnetic bead turbid solution reagent is determined by its physical characteristic, once stands and is easy to produce precipitation；If
This magnetic bead reagent occur precipitation participate in again correlated response will have a strong impact on test result stability and can
By property；So, needed to be mixed before using magnetic bead reagent.The most mostly use rabbling mechanism pair
Magnetic bead reagent is stirred mixing, recycles other equipment afterwards and magnetic bead reagent is done dose, this
Method also needs to be carried out puddler, in time carrying out multitask mixing, is easily created reagent
Cross-contamination.Still an alternative is that the device using high frequency to handle up, during utilization, liquid produces
Lasing power mixes, although this method can solve the problem of cross-contamination, but does not the most solve
The requirement that multiple magnetic bead reagent mixes simultaneously.On the other hand, mixing is brought again by mixing of handling up consistent
Property is poor, and the later stage takes the problems such as liquid waiting time length.
Summary of the invention
The problem that the invention is to be solved is to provide a kind of magnetic bead reagent evenly mixing device, is especially suitable for solving
Can not multitask simultaneously mix present in existing magnetic bead reagent uniform mixing equipment, mixing concordance is poor, efficiency
The problem such as low.
For solving above-mentioned technical problem, the invention the technical scheme is that
There is provided a kind of magnetic bead reagent evenly mixing device, including power part, the first mixing portion and the second mixing portion；
Described power part include motor, the small synchronous pulley being connected with motor and by Timing Belt with
The big synchronous pulley that small synchronous pulley is connected；First mixing portion includes that be connected with big synchronous pulley respectively turns
Dish and the first gear wheel, the little bottle holder being positioned on rotating disk and be positioned at the first little gear of little bottle holder bottom；
Second mixing portion includes the second largest gear being connected with big synchronous pulley bottom, engages with second largest gear
Two pinion, with two pinion bottom meshed gears B and gear B meshed gears A and
The big bottle holder being connected with gear A.
Wherein, described little bottle holder quantity be 2 and more than, circle distribution is on rotating disk.
Wherein, described big bottle holder includes a bottle holder our department and a bottle holder axle, and bottle holder our department is positioned at and turns
On dish, bottle holder axle is connected with gear A.
Wherein, described rotating disk has a circular hollow, and the diameter of described circular hollow is not less than described big bottle
The diameter of bottle holder our department of torr.
Wherein, described magnetic bead reagent evenly mixing device also includes base plate A and base plate B, and motor is positioned at
On base plate A, connected by support bar between described base plate A and base plate B.
Wherein, described motor is 57 series two-phase stepping motors.
The invention has the advantage that with good effect: can the most quickly mix the examination of multiple magnetic bead
Agent, owing to rotating speed is consistent, so mixing result concordance is high, does not haves friendship in blending process simultaneously
Fork pollutes, and can directly carry out next step test, shorten the bulk testing cycle after having mixed.
Accompanying drawing explanation
Fig. 1 is the overall structure schematic diagram of the invention
In figure:
1, power part 1-1, motor 1-2, small synchronous pulley
1-3, Timing Belt 1-4, big synchronous pulley the 2, first mixing portion
2-1, rotating disk 2-2, the first gear wheel 2-3, the first little gear
2-4, little bottle holder the 3, second mixing portion 3-1, second largest gear
3-2, two pinion 3-3, gear A 3-4, gear B
3-5, big bottle holder 4, base plate A 5, base plate B
Detailed description of the invention
Below in conjunction with the accompanying drawings the specific embodiment of the invention is elaborated.
As shown in Figure 1, the invention includes power part, the first mixing portion and the second mixing portion；Described
Power part include motor, the small synchronous pulley being connected with motor and by Timing Belt with little with
The big synchronous pulley that step belt wheel is connected；First mixing portion include the rotating disk that is connected with big synchronous pulley respectively and
First gear wheel, the little bottle holder being positioned on rotating disk and be positioned at the first little gear of little bottle holder bottom；Second
Mixing portion includes the second largest gear being connected with big synchronous pulley bottom, second engaged with second largest gear
Little gear, with two pinion bottom meshed gears B and gear B meshed gears A and and tooth
The big bottle holder that wheel A is connected.Little bottle holder quantity be 2 and more than, circle distribution is on rotating disk.Described
Big bottle holder includes a bottle holder our department and a bottle holder axle, and bottle holder our department is positioned on rotating disk, bottle holder axle and tooth
Wheel A is connected.Described rotating disk has a circular hollow, and the diameter of described circular hollow is not less than described big bottle
The diameter of bottle holder our department of torr.Described magnetic bead reagent evenly mixing device also includes base plate A and base plate B, step
Enter motor to be positioned on base plate A, connected by support bar between described base plate A and base plate B.
The invention using method is as follows, will be equipped with the big bottle of magnetic bead reagent and some equipped with magnetic bead reagent
Bottle be respectively placed in big bottle holder and little bottle holder.Starting motor, motor rotarily drives little same
Step belt wheel rotates, and by Timing Belt, power is sent to big synchronous pulley, drives first be attached thereto big
Gear, rotating disk and second largest gear rotate.Turntable rotation drives little bottle holder to rotate, the first gear wheel and the
After one little gear engagement, the first little bottle holder of little gear driven rotates, it may be assumed that the little bottle holder on rotating disk exists
While revolving round the sun around the big bottle holder of center of turntable, each little bottle holder is at the first little tooth being each connected
Wheel also carries out rotation under driving, thus completes the mixing of magnetic bead reagent in bottle.
Second largest gear rotarily drives two pinion and rotates, and then drives the gear B being meshed therewith,
Power engaged transmission is given again gear A by gear B, and gear A is connected with the bottle holder axle of big bottle holder, thus
Realize the mixing to bottle magnetic bead reagent big in bottle holder our department.
The invention has the advantage that with good effect: can the most quickly mix the examination of multiple magnetic bead
Agent, owing to rotating speed is consistent, so mixing result concordance is high, does not haves friendship in blending process simultaneously
Fork pollutes, and can directly carry out next step test, shorten the bulk testing cycle after having mixed.
Above an embodiment of the invention is described in detail, but described content has been only this
The preferred embodiment of bright creation, it is impossible to be considered the practical range for limiting the invention.Fan Yiben
Equalization change and the improvement etc. that innovation and creation application range is made, all should still belong to the special of the invention
Within profit covering scope.
Claims (6)
1. a magnetic bead reagent evenly mixing device, it is characterised in that: include power part, the first mixing portion and
Second mixing portion；The small synchronous pulley that described power part includes motor, be connected with motor with
And the big synchronous pulley being connected with small synchronous pulley by Timing Belt；First mixing portion includes respectively with the most Tong Bu
Rotating disk that belt wheel is connected and the first gear wheel, the little bottle holder being positioned on rotating disk and be positioned at little bottle holder bottom
First little gear；Second mixing portion includes the second largest gear being connected with big synchronous pulley bottom, with second
The two pinion of gear wheel engagement, engages with gear B with two pinion bottom meshed gears B
Gear A and the big bottle holder that is connected with gear A.
A kind of magnetic bead reagent evenly mixing device the most according to claim 1, it is characterised in that: described
Little bottle holder quantity be 2 and more than, circle distribution is on rotating disk.
A kind of magnetic bead reagent evenly mixing device the most according to claim 2, it is characterised in that: described
Big bottle holder include a bottle holder our department and a bottle holder axle, bottle holder our department is positioned on rotating disk, bottle holder axle with
Gear A is connected.
A kind of magnetic bead reagent evenly mixing device the most according to claim 3, it is characterised in that: described
Rotating disk have a circular hollow, the diameter of described circular hollow is not less than bottle holder our department of described big bottle holder
Diameter.
A kind of magnetic bead reagent evenly mixing device the most according to claim 4, it is characterised in that: described
Magnetic bead reagent evenly mixing device also includes base plate A and base plate B, and motor is positioned on base plate A, described
Connected by support bar between base plate A and base plate B.
A kind of magnetic bead reagent evenly mixing device the most according to claim 5, it is characterised in that: described electricity
Machine is 57 series two-phase stepping motors.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410524578.7A CN104226168B (en) | 2014-09-30 | 2014-09-30 | A kind of magnetic bead reagent evenly mixing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410524578.7A CN104226168B (en) | 2014-09-30 | 2014-09-30 | A kind of magnetic bead reagent evenly mixing device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104226168A CN104226168A (en) | 2014-12-24 |
| CN104226168B true CN104226168B (en) | 2016-09-28 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410524578.7A Active CN104226168B (en) | 2014-09-30 | 2014-09-30 | A kind of magnetic bead reagent evenly mixing device |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107308690B (en) * | 2017-06-28 | 2020-06-05 | 迈克医疗电子有限公司 | Method and apparatus for suppressing bubble, computer readable storage medium |
| CN113015910A (en) * | 2019-04-22 | 2021-06-22 | 深圳迈瑞生物医疗电子股份有限公司 | Mixing device and mixing method of magnetic bead reagent and sample analysis equipment |
| CN110456091B (en) * | 2019-10-11 | 2020-02-07 | 潍坊市康华生物技术有限公司 | Reagent disk magnetic bead mixing device and using method |
| CN114910657B (en) * | 2022-07-15 | 2022-10-21 | 山东第一医科大学第一附属医院(山东省千佛山医院) | Anal secretion detection device |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0642936B2 (en) * | 1989-12-22 | 1994-06-08 | 株式会社クボタ | Mixer |
| CN2732341Y (en) * | 2004-06-29 | 2005-10-12 | 冈贸股份有限公司 | Driving mechanism of blending machine |
| JP2014030812A (en) * | 2012-08-06 | 2014-02-20 | Marcom:Kk | Kneader and treatment method |
| CN203227447U (en) * | 2013-05-23 | 2013-10-09 | 博奥赛斯（天津）生物科技有限公司 | Magnetic bead mixing device |
| CN204193846U (en) * | 2014-09-30 | 2015-03-11 | 博奥赛斯（天津）生物科技有限公司 | A kind of magnetic bead reagent evenly mixing device |
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| CN104226168A (en) | 2014-12-24 |
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Address after: 300300 building 14, international medical device Industrial Park, No. 16, Wujing Road, economic and Technological Development Zone, Dongli District, Tianjin Patentee after: Tianjin boasaisi Biotechnology Co.,Ltd. Address before: 300300 No. 10, Siwei Road, development zone, Dongli District, Tianjin Patentee before: BIOSCIENCE (TIANJIN) DIAGNOSTIC TECHNOLOGY Co.,Ltd. |
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