CN104225787A - Wound dressing - Google Patents
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- CN104225787A CN104225787A CN201410425998.XA CN201410425998A CN104225787A CN 104225787 A CN104225787 A CN 104225787A CN 201410425998 A CN201410425998 A CN 201410425998A CN 104225787 A CN104225787 A CN 104225787A
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Abstract
The invention discloses wound dressing which comprises a base material, first electrodes formed on the upper surface of the base material and second electrodes formed on the upper surface of the base material, the first electrodes are noble electrodes or reaction electrodes containing oxidizing agents, and the second electrodes are reaction electrodes containing reducing agents. The first electrodes and the second electrodes do not make direct contact, and when electric conduction materials exist, current is generated between the first electrodes and the second electrodes. The wound dressing can be used for damaged, or inflamed, or sick, or infected or healthy biological tissue, and is low in cost and suitable for popularization in the society.
Description
Technical field
The invention belongs to field of medical technology, specifically, the present invention relates to a kind of wound dressing.
Background technology
The function influence of the micro-electric current of physiology to human body has years of researches history.Early stage research shows, the micro-electric current of physiology is prevalent in tissue, and contributes to wound healing.When skin injury, bio electrochemistry reactions different between each organized layer produces bioelectrical activity, and these bioelectrical activities are generally confined to edge of wound, and consequent micro-electric current is that cell migration provides driving force.Comprehensive existing list of references finds, the micro-electric current therapy of physiology has the following advantages wound and treating acne tool by concentrating behavioral pattern: acceleration cell regeneration, tissue repair, acceleration skin barrier recover (even under very low electric current), improve blood circulation, improve and breathe and reduce cicatrix etc.
Although there are these viewpoints, the micro-electric current therapy of physiology is not able to extensive use in trauma care, particularly because general electric current therapy needs fixing expensive power-supply device, is not suitable for family and uses.
Therefore, the micro-electric current therapy of existing physiology needs further genralrlization.
Summary of the invention
The present invention is intended to solve one of technical problem in correlation technique at least to a certain extent.For this reason, one object of the present invention is to propose a kind of wound dressing, and this wound dressing can be applied to damage, inflammation, ill, infected, healthy biological tissue, and cheap, is suitable for society generalization.
In one aspect of the invention, the present invention proposes a kind of wound dressing, comprising:
Base material;
First electrode, described first electrode is formed in the upper surface of described base material, and described first electrode is inert electrode or the reaction electrode containing oxidant; And
Second electrode, described second electrode is formed in the upper surface of described base material, and described second electrode is the reaction electrode containing reducing agent,
Wherein, described first electrode does not directly contact mutually with described second electrode, and when there is conductive materials, can generation current between described first electrode and described second electrode.
Electricity irritation and current processing combine by the wound dressing according to the embodiment of the present invention, by using inert electrode or containing the reaction electrode of oxidant and the reaction electrode containing reducing agent, when there being conductive materials to exist, redox reaction is there is between dissimilar electrode, generation current, thus reach the object healed a wound, this dressing simultaneously does not need fixing expensive power-supply device, thus its cost is significantly reduced, and then be suitable for society generalization.
In addition, wound dressing according to the above embodiment of the present invention can also have following additional technical characteristic:
In some embodiments of the invention, described conductive materials is normal saline, aseptic liquid medicine or wound fluid.Thus, medium can be provided for electron transfer.
In some embodiments of the invention, described aseptic liquid medicine is medical alcohol, medical hydrogen peroxide, povidone iodine, mercurochrome or gentian voiet.Thus, wound healing degree can be significantly improved.
In some embodiments of the invention, described inert electrode contains at least one in silver, gold, platinum and carbon, described oxidant is at least one in silver oxide, Argentous fluoride, silver chloride, Silver monobromide, silver iodide, copper oxide, copper fluoride, copper chloride, copper bromide and Copper diiodide, and described reducing agent is at least one in zinc, magnesium, aluminum, ferrum, copper.Thus, can under not needing external power source to there is situation generation current, thus reach the object healed a wound.
In some embodiments of the invention, described base material comprises: basic unit; Coating, described coating formation is in the upper surface of described basic unit; Absorbed layer, described absorbed layer is formed at the upper surface of described coating; And substrate layer, described substrate layer is formed at the upper surface of described absorbed layer, and described first electrode and described second electrode are formed in described substrate layer on the surface.Thus, this dressing can be made relative with wound surface position fixing.
In some embodiments of the invention, described substrate layer contains at least one in rigid material and flexible material.
In some embodiments of the invention, described rigid material is be selected from least one in bioceramic, silicates glass, borate family glass, sugared glass.
In some embodiments of the invention, described flexible material is be selected from least one in politef, silicones, polyurethane foam, elastomer, synthetic sponge, natural sponge, silk, keratin, cellulose fibre, artificial silk, modified acrylic fibre, polyamide membrane, polyester film, polyolefin film and polyvinyl alcohol film.Thus, substrate and the intact laminating of wound surface can be made.
In some embodiments of the invention, described substrate layer comprises binding agent and softening agent further.
In some embodiments of the invention, described binding agent is be selected from least one in polrvinyl chloride, politef, polyvinyl alcohol, polyester, polyamide and resin.
In some embodiments of the invention, described softening agent is be selected from least one in glycerol, propylene glycol, Polyethylene Glycol, phthalate derivatives, citrate and surfactant.Thus, the laminating degree of substrate and wound surface can be improved further.
In some embodiments of the invention, described first electrode and described second electrode are separately rectangle, square, circle, ellipse or hexagon, and wherein, described rectangular length is 10nm ~ 10cm, described rectangular wide be 1nm ~ 2mm.Thus, wound healing degree can be improved further.
In some embodiments of the invention, the first electrode described at least one is provided with between two adjacent described second electrodes.Thus, can ensure to produce stable micro-electric current when there is conductive materials.
In some embodiments of the invention, described multiple first electrode forms the first pattern, and described multiple second electrode forms the second pattern, and described first pattern is nested in described second pattern.Thus, can ensure to produce stable micro-electric current when there is conductive materials.
In some embodiments of the invention, 0.5 ~ 2mm is spaced apart between adjacent described first electrode and described second electrode.Thus, can effectively heal a wound.
In some embodiments of the invention, between described multiple first electrode and described multiple second electrode, potential difference summation is 0.05 ~ 5V, and electric current summation is 1 ~ 100mA.Thus, wound healing degree can be improved further.
In some embodiments of the invention, described wound dressing comprises lining layer further, and described lining layer is formed on the surface of described first electrode and described second electrode, and is suitable for the described coating of protection before wound dressing application.Thus, can available protecting coating from physics and/or environmental damage.
Accompanying drawing explanation
Fig. 1 is the structural representation of wound dressing according to an embodiment of the invention;
Fig. 2 is the structural representation of the wound dressing according to another embodiment of the present invention;
Fig. 3 is the structural representation of the wound dressing according to another embodiment of the present invention;
Fig. 4 is the structural representation of the wound dressing according to another embodiment of the present invention;
Fig. 5 is the structural representation of the wound dressing according to another embodiment of the present invention.
Detailed description of the invention
Be described below in detail embodiments of the invention, the example of described embodiment is shown in the drawings, and wherein same or similar label represents same or similar element or has element that is identical or similar functions from start to finish.Be exemplary below by the embodiment be described with reference to the drawings, be intended to for explaining the present invention, and can not limitation of the present invention be interpreted as.
In describing the invention, it will be appreciated that, term " " center ", " longitudinal direction ", " transverse direction ", " length ", " width ", " thickness ", " on ", D score, " front ", " afterwards ", " left side ", " right side ", " vertically ", " level ", " top ", " end ", " interior ", " outward ", " clockwise ", " counterclockwise ", " axis ", " radial direction ", orientation or the position relationship of the instruction such as " circumference " are based on orientation shown in the drawings or position relationship, only the present invention for convenience of description and simplified characterization, instead of indicate or imply that the device of indication or element must have specific orientation, with specific azimuth configuration and operation, therefore limitation of the present invention can not be interpreted as.
In addition, term " first ", " second " only for describing object, and can not be interpreted as instruction or hint relative importance or imply the quantity indicating indicated technical characteristic.Thus, be limited with " first ", the feature of " second " can express or impliedly comprise at least one this feature.In describing the invention, the implication of " multiple " is at least two, such as two, three etc., unless otherwise expressly limited specifically.
In the present invention, unless otherwise clearly defined and limited, the term such as term " installation ", " being connected ", " connection ", " fixing " should be interpreted broadly, and such as, can be fixedly connected with, also can be removably connect, or integral; Can be mechanical connection, also can be electrical connection; Can be directly be connected, also indirectly can be connected by intermediary, can be the connection of two element internals or the interaction relationship of two elements, unless otherwise clear and definite restriction.For the ordinary skill in the art, above-mentioned term concrete meaning in the present invention can be understood as the case may be.
In the present invention, unless otherwise clearly defined and limited, fisrt feature second feature " on " or D score can be that the first and second features directly contact, or the first and second features are by intermediary mediate contact.And, fisrt feature second feature " on ", " top " and " above " but fisrt feature directly over second feature or oblique upper, or only represent that fisrt feature level height is higher than second feature.Fisrt feature second feature " under ", " below " and " below " can be fisrt feature immediately below second feature or tiltedly below, or only represent that fisrt feature level height is less than second feature.
In one aspect of the invention, the present invention proposes a kind of wound dressing.Wound dressing below with reference to Fig. 1-4 pairs of embodiment of the present invention is described in detail.According to embodiments of the invention, this wound dressing can comprise: base material 100, first electrode 200 and the second electrode 300, according to a particular embodiment of the invention, first electrode 200 can be formed in the upper surface of base material 100, and the first electrode 200 can be inert electrode or the reaction electrode containing oxidant, second electrode 300 can be formed in the upper surface of base material 100, and the second electrode 300 can for the reaction electrode containing reducing agent, according to concrete example of the present invention, first electrode 200 does not directly contact mutually with the second electrode 300, and when there is conductive materials, can generation current between first electrode 200 and the second electrode 300.According to embodiments of the invention, the particular type of the active substance in the first electrode is also not particularly limited, and according to a particular embodiment of the invention, if be inert electrode, active substance can be at least one in silver, gold, platinum and carbon; If reaction electrode, active substance oxidant can be at least one in silver oxide, Argentous fluoride, silver chloride, Silver monobromide, silver iodide, copper oxide, copper fluoride, copper chloride, copper bromide and Copper diiodide.According to embodiments of the invention, in the second electrode active substance particular type and be not particularly limited, according to a particular embodiment of the invention, active substance reducing agent can be at least one in zinc, magnesium, aluminum, ferrum, copper.According to embodiments of the invention, the particular type of conductive materials is also not particularly limited, according to a particular embodiment of the invention, conductive materials can be normal saline, aseptic liquid medicine or wound fluid, according to concrete example of the present invention, aseptic liquid medicine can be medical alcohol, medical hydrogen peroxide, povidone iodine, mercurochrome or gentian voiet.Concrete, for normal saline, when using wound dressing, be first soak in the normal saline of 0.9wt% in concentration by wound dressing, make the first electrode and the second electrode mediate contact, thus redox reaction occurs, be the first electrode with silver oxide, be the second electrode with zinc, wherein, the first electrode generation reduction reaction: O
2+ 4e
-+ H
2o=OH
-, the second electrode generation oxidation reaction: Zn=Zn
2++ 2e
-, thus generation current.Inventor finds, by using inert electrode or containing the first electrode of oxidant and the second electrode containing reducing agent, when there being conductive materials to exist, redox reaction is there is between dissimilar electrode, generation current, thus the healing to wound can be realized, do not need fixed power source equipment simultaneously, thus significantly reduce its cost, and improve the portability of product.
With reference to figure 2, according to embodiments of the invention, base material 100 can comprise basic unit 110, coating 120, absorbed layer 130 and substrate layer 140, according to a particular embodiment of the invention, coating 120 can be formed at the upper surface of basic unit 110, absorbed layer 130 can be formed at the upper surface of coating 120, and substrate layer 140 can be formed at the upper surface of absorbed layer 130, and the first electrode 200 and the second electrode 300 can be formed on the surface of substrate layer 140.According to embodiments of the invention, the surface of substrate layer 140 can be basic plane or on-plane surface, and the first electrode 200 and the second electrode 300 physical separation in whole substrate layer 140, according to a particular embodiment of the invention, first electrode 200 can a little more than substrate layer 140 surface, a little less than substrate layer 140 surface or equal with substrate layer 140 surface with the relative position on the second electrode 300 surface, concrete, the first electrode and the second electrode surface and substrate layer surface relative position can make the electronics between two kinds of electrodes and/or ionic conduction be achieved.
According to embodiments of the invention, the shape of substrate layer is also not particularly limited, and according to a particular embodiment of the invention, substrate layer can be bulk, stratiform, lamellar or membranaceous.According to embodiments of the invention, substrate layer can containing at least one in rigid material and flexible material, and flexible material can contact with wound surface in use, makes this dressing can laminating intact with wound surface thus.According to embodiments of the invention, the particular type of rigid material and flexible material is also not particularly limited, according to a particular embodiment of the invention, rigid material can be bioceramic, silicates glass, at least one in borate family glass and sugared glass, flexible material can for being selected from politef, silicones, polyurethane foam, elastomer, synthetic sponge, natural sponge, silk, keratin, cellulose fibre, artificial silk, modified acrylic fibre, polyamide membrane, polyester film, at least one in polyolefin film and polyvinyl alcohol film.
According to embodiments of the invention, substrate layer can contain binding agent and softening agent further.According to embodiments of the invention, the particular type of binding agent is also not particularly limited, and according to a particular embodiment of the invention, binding agent can for being selected from least one in polrvinyl chloride, politef, polyvinyl alcohol, polyester, polyamide and resin.According to embodiments of the invention, the particular type of softening agent is also not particularly limited, according to a particular embodiment of the invention, softening agent can for being selected from least one in glycerol, propylene glycol, Polyethylene Glycol, phthalate derivatives, citrate and surfactant.Concrete, binding agent may be used for linking together bonding with substrate surface for each component of the first and second electrode materials, and softening agent may be used for flexibility and the flexibility of increase by first and second electrode material.
According to embodiments of the invention, the shape of the first electrode and the second electrode is also not particularly limited, according to a particular embodiment of the invention, first electrode and the second electrode can be independently rectangle, square, circle, ellipse or hexagon, wherein, rectangular length can be 10nm ~ 10cm, rectangular wide be 1nm ~ 2mm, and two kinds of electrode sizes can have one or more dimension.According to embodiments of the invention, base material can be provided with multiple first electrode and multiple second electrode.According to embodiments of the invention, multiple first electrode and multiple second distribution of electrodes mode are also not particularly limited, and according to a particular embodiment of the invention, can be provided with at least one first electrode between two adjacent the second electrodes.According to embodiments of the invention, multiple first electrode can form the first pattern, and multiple second electrode can form the second pattern, and the first pattern can be nested in the second pattern.According to embodiments of the invention, the interval between the first adjacent electrode and the second electrode is also not particularly limited, and according to a particular embodiment of the invention, the interval between the first adjacent electrode and the second electrode can be 0.5 ~ 2mm.Inventor finds, if spacing distance is too small between the first electrode and the second electrode, easily causes the short circuit between the first and second electrodes; And if interval is excessive, dressing internal resistance increases, and the electric field intensity being supplied to wound surface reduces, and the ability that electric current penetrates wound surface reduces greatly.Thus, select within the scope of this spacing distance, make each monocell can set up the voltage of about 0.5 ~ 2V on wound surface surface, its electric field intensity provided makes electric current have to penetrate the basic potentiality of wound surface corium and epidermis, penetration depth is about 0.5mm, thus realizes the healing to wound.
According to embodiments of the invention, the potential difference of multiple first electrode and multiple second electrode and electric current are also not particularly limited, according to a particular embodiment of the invention, the potential difference summation of multiple first electrode and multiple second electrode can be 0.05 ~ 5V, and electric current summation can be 1 ~ 100mA.Inventor finds, within the scope of this voltage and current, simulate micro-electric current not only can drive the first and second electrode active materials (as, silver and zinc) kill antibacterial at wound surface, and the micro-electric current of this simulation can exist in the degree of depth that wound surface is about 0.5mm, promote the relevant neutrophil cell of wound healing, macrophage and fibroblastic chemotactic enrichment at wound surface, induction healing acceleration process, and stimulate this regional nerve tip, promote that they participate in wound healing.
According to embodiments of the invention, between two kinds of electrodes and when the place contacted with it there is conductive materials, the first electrode 200 can and generation current between one or more second electrodes 300 of closing on of physics each other.As shown in Figure 3, the first electrode 201,202 and second electrode 301 is adjacent, is called electrode subset, and other electrodes beyond electrode subset also can be adjacent with the second electrode 301, and adjacent electrode spacing can be substantially even or different.When there is conductive materials between two kinds of electrodes, be that electronics between two kinds of electrodes and/or ion migration provide transmission medium, redox reaction occurred automatically, wherein the first electrode generation reduction reaction, second electrode generation oxidation reaction, thus generation current.
Concrete, in first electrode and the second electrode, the content of active substance or electrode number can be determined according to therapeutic purposes, and the content of two kinds of electrode active materials should be able to guarantee that mouthful dressing maintains certain wear rate until electrode active material exhausts being electrically activated in later a period of time; The number of two kinds of electrodes should be able to maintain after wound dressing is activated has one or more electric current.Wherein, the active substance of two kinds of electrodes is gradually consumed after activation wound dressing, if the first electrode contains active substance zinc containing active substance silver oxide, the second electrode, after wound dressing is activated, part or all of zinc is moved out gradually respective electrode under electromotive force effect, causes the voltage between two electrodes to be reduced to zero gradually.When the second electrode active material exhausts or voltage significantly reduces, the reaction between two kinds of electrodes will reduce, and even terminates.In addition, electrode active material can also have certain curative effect to wound surface healing, and make it in some cases, even if the reaction between two kinds of electrodes terminates, this electrode active material still can play the effect of maintaining treatment.Therefore, should can also continue to maintain its usefulness after reaction stops containing the electrode corresponding size or concentration with therapeutic effect active substance.Such as, the first electrode is containing a large amount of silver, and the second electrode is containing a large amount of zinc, and when the redox reaction between electrode stops, silver is also not depleted, still has corresponding antibacterial action.
As shown in Figure 4, the current conditions between the dissimilar electrode of wound dressing is as follows: the first electrode 201,202 and 203 is containing one or more oxidants, and the second electrode 301 and 302 is containing one or more reducing agents, and vice versa.When conductive materials (not shown) is distributed between the first electrode 201,202 and 203 and the second electrode 301 and 302, between two kinds of electrodes, there is redox reaction, produce electric current as shown in the figure.
As we can see from the figure, substrate layer surface can produce multiple electron current, thus creates the surface current comprising multiple electron current at whole substrate surface.Electric current between two adjacent Different electrodes can be described as " monocell electric current ", and the set of multiple monocell electric current can be described as " many battery currents " electric current across substrate surface, and its electric current density can be substantially even, also can change to some extent.The electric current of many batteries affects by factors such as adjacent xenogenesis electrode spacing, potential difference, conductive material resistance.When these factors change, electron current can change in time.Wherein, the potential difference between dissimilar electrode can be 0.05 ~ 5.0V, and electric current can be 1 ~ 100mA, conductive materials resistance generally from close to zero to infinity.When wound dressing is applied to wound surface and is activated, the total current between dissimilar electrode is wound surface electric current and conductive material electric current sum.When wound surface resistance is greater than conductive material resistance, the electric current through conductive material may more than the electric current through wound surface.Therefore, for certain conductive material, its resistance can be greater than or less than the ideal resistance of wound surface, and whether determine thus has more or less electric current to flow through wound surface.
Often organize adjacent dissimilar electrode (as electrode 201 and 301) can form one " galvanic element ".When a certain electrode is adjacent with multiple dissimilar electrode, this electrode is a part for multiple galvanic element.Such as, electrode 201 can form two galvanic elements respectively with multiple dissimilar electrode 301,302.Each galvanic element contains a positive pole and a negative pole, thus with the form storage power of chemical potential energy.When conductive materials is positioned near a galvanic element, this conductive materials can be between each electrochemical cell and provides electronics and/or ion conducting medium, and chemical potential energy is released to electric energy.Therefore, often organize adjacent dissimilar electrode and can be used as an independent galvanic element, and multiple adjacent xenogenesis electrod-array can form a battery territory, thus form array more than at substrate surface.
First electrode is inert electrode or for containing the reaction electrode of oxidant, during the reaction electrode of the second electrode containing reducing agent (vice versa), there is electric potential difference between two kinds of electrodes.When not having conductive materials, the electric current between wound dressing electrode is zero, and when there is conductive materials, wound dressing is activated, thus by electron conduction and/or ionic conduction generation current in-between the electrodes.When electric current is put on wound surface by wound dressing, be electron conduction between the first electrode and the second electrode, and two kinds of electrodes and and wound surface between be ionic conduction.
With reference to figure 5, the wound dressing of the embodiment of the present invention comprises further:
Lining layer 400: according to embodiments of the invention, lining layer 400 can be formed on the first electrode and the second electrode surface, is suitable for protective finish 120 before wound dressing application.
As mentioned above, can have according to the wound dressing of the embodiment of the present invention and be selected from following advantage one of at least:
Proliferation of fibrous tissue (e.g., connective tissue regeneration) can be stimulated according to the wound dressing of the embodiment of the present invention;
Collagen protein (e.g., collagen fiber reform) can be reinvented according to the wound dressing of the embodiment of the present invention;
Angiogenesis (e.g., organizing blood supply to regenerate) can be stimulated according to the wound dressing of the embodiment of the present invention;
According to the wound dressing of the embodiment of the present invention, there is anti-microbial effect (e.g., electrode active material is attractive to microorganism, and destroys its memebrane protein);
Electromotive force can be provided to drive (as silver and/or the zinc) arrival of one or more materials or target approach to organize district's (as ionotherapy) according to the wound dressing of the embodiment of the present invention, and suction band electric charge healing cell move;
Can stimulate according to the wound dressing of the embodiment of the present invention organizes injury to produce general bioelectric current;
Can wound contraction according to the wound dressing of the embodiment of the present invention;
Wound dressing according to the embodiment of the present invention can by providing the galvanism of whole wound surface whole wound healing;
Wound dressing according to the embodiment of the present invention can change capillary permeability;
Cytoactive can be changed according to the wound dressing of the embodiment of the present invention and excessively return to poised state from vigor decline or vigor;
According to the wound dressing of the embodiment of the present invention can regulating cell induction, regulating cell differentiation and/or dedifferente, regulating cell apoptosis, regulating cell form, regulating cell function, regulating cell are movable, regulating cell chemism and/or behavior.
In the description of this description, specific features, structure, material or feature that the description of reference term " embodiment ", " some embodiments ", " example ", " concrete example " or " some examples " etc. means to describe in conjunction with this embodiment or example are contained at least one embodiment of the present invention or example.In this manual, to the schematic representation of above-mentioned term not must for be identical embodiment or example.And the specific features of description, structure, material or feature can combine in one or more embodiment in office or example in an appropriate manner.In addition, when not conflicting, the feature of the different embodiment described in this description or example and different embodiment or example can carry out combining and combining by those skilled in the art.
Although illustrate and describe embodiments of the invention above, be understandable that, above-described embodiment is exemplary, can not be interpreted as limitation of the present invention, and those of ordinary skill in the art can change above-described embodiment within the scope of the invention, revises, replace and modification.
Claims (18)
1. a wound dressing, is characterized in that, comprising:
Base material;
First electrode, described first electrode is formed in the upper surface of described base material, and described first electrode is inert electrode or the reaction electrode containing oxidant; And
Second electrode, described second electrode is formed in the upper surface of described base material, and described second electrode is the reaction electrode containing reducing agent,
Wherein, described first electrode does not directly contact mutually with described second electrode, and when there is conductive materials, can generation current between described first electrode and described second electrode.
2. want the wound dressing described in 1 according to right, it is characterized in that, described conductive materials is normal saline, aseptic liquid medicine or wound fluid.
3. want the wound dressing described in 2 according to right, it is characterized in that, described aseptic liquid medicine is medical alcohol, medical hydrogen peroxide, povidone iodine, mercurochrome or gentian voiet.
4. wound dressing according to claim 1, it is characterized in that, described inert electrode contains at least one in silver, gold, platinum and carbon, described oxidant is at least one in silver oxide, Argentous fluoride, silver chloride, Silver monobromide, silver iodide, copper oxide, copper fluoride, copper chloride, copper bromide and Copper diiodide, and described reducing agent is at least one in zinc, magnesium, aluminum, ferrum, copper.
5. wound dressing according to claim 1, is characterized in that, described base material comprises:
Basic unit;
Coating, described coating formation is in the upper surface of described basic unit;
Absorbed layer, described absorbed layer is formed at the upper surface of described coating; And
Substrate layer, described substrate layer is formed at the upper surface of described absorbed layer, and described first electrode and described second electrode are formed in described substrate layer on the surface.
6. wound dressing according to claim 5, is characterized in that, described substrate layer contains at least one in rigid material and flexible material.
7. wound dressing according to claim 6, is characterized in that, described rigid material is be selected from least one in bioceramic, silicates glass, borate family glass and sugared glass.
8. wound dressing according to claim 6, it is characterized in that, described flexible material is be selected from least one in politef, silicones, polyurethane foam, elastomer, synthetic sponge, natural sponge, silk, keratin, cellulose fibre, artificial silk, modified acrylic fibre, polyamide membrane, polyester film, polyolefin film and polyvinyl alcohol film.
9. wound dressing according to claim 5, is characterized in that, described substrate layer is further containing binding agent and softening agent.
10. wound dressing according to claim 9, is characterized in that, described binding agent is be selected from least one in polrvinyl chloride, politef, polyvinyl alcohol, polyester, polyamide and resin.
11. wound dressings according to claim 9, is characterized in that, described softening agent is be selected from least one in glycerol, propylene glycol, Polyethylene Glycol, phthalate derivatives, citrate and surfactant.
12. wound dressings according to claim 1, it is characterized in that, described first electrode and described second electrode are separately rectangle, square, circle, ellipse or hexagon, wherein, described rectangular length is 10nm ~ 10cm, described rectangular wide be 1nm ~ 2mm.
13. wound dressings according to claim 1, is characterized in that, comprise multiple first electrode and multiple second electrode.
14. wound dressings according to claim 13, is characterized in that, are provided with the first electrode described at least one between two adjacent described second electrodes.
15. wound dressings according to claim 13, is characterized in that, described multiple first electrode forms the first pattern, and described multiple second electrode forms the second pattern, and described first pattern is nested in described second pattern.
16. wound dressings according to claim 13, is characterized in that, are spaced apart 0.5 ~ 2mm between adjacent described first electrode and described second electrode.
17. wound dressings according to claim 13, is characterized in that, between described multiple first electrode and described multiple second electrode, potential difference summation is 0.05 ~ 5V, and electric current summation is 1 ~ 100mA.
18. wound dressings according to claim 5, is characterized in that, comprise lining layer further, and described lining layer is formed on the surface of described first electrode and described second electrode, and are suitable for the described coating of protection before wound dressing application.
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| CN106038063A (en) * | 2015-04-14 | 2016-10-26 | 财团法人纺织产业综合研究所 | dressing for wound care |
| TWI617327B (en) * | 2016-09-26 | 2018-03-11 | Self-generating material and method of manufacturing same | |
| CN107925094A (en) * | 2015-08-28 | 2018-04-17 | 芬兰国家技术研究中心股份公司 | Device for electro-chemical cell |
| CN110139680A (en) * | 2016-10-19 | 2019-08-16 | 3M创新有限公司 | Antimicrobial articles |
| CN110507908A (en) * | 2019-08-28 | 2019-11-29 | 京东方科技集团股份有限公司 | Electronics wound dressing and preparation method thereof |
| CN111616860A (en) * | 2020-06-29 | 2020-09-04 | 江苏恩福赛柔性电子有限公司 | Electronic wound plaster and manufacturing method thereof |
| CN114126556A (en) * | 2019-07-11 | 2022-03-01 | 沃莫瑞斯创新公司 | Method and apparatus for treating external fixation sites |
| US11311715B2 (en) | 2018-10-12 | 2022-04-26 | Cymmetrik Enterprise Co., Ltd. | Self-powered sheet |
| US20220152267A1 (en) * | 2020-11-18 | 2022-05-19 | Cymmetrik Enterprise Co., Ltd. | Wound dressing |
| CN114712087A (en) * | 2022-02-25 | 2022-07-08 | 长沙海润生物技术有限公司 | Antibacterial dressing capable of generating directional electric field and preparation method thereof |
| WO2023130265A1 (en) * | 2022-01-05 | 2023-07-13 | 陆一平 | Composition of surface microstructure of wound dressing |
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| US11311715B2 (en) | 2018-10-12 | 2022-04-26 | Cymmetrik Enterprise Co., Ltd. | Self-powered sheet |
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| US20220152267A1 (en) * | 2020-11-18 | 2022-05-19 | Cymmetrik Enterprise Co., Ltd. | Wound dressing |
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| WO2023130265A1 (en) * | 2022-01-05 | 2023-07-13 | 陆一平 | Composition of surface microstructure of wound dressing |
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