WO2023130265A1

WO2023130265A1 - Composition of surface microstructure of wound dressing

Info

Publication number: WO2023130265A1
Application number: PCT/CN2022/070339
Authority: WO
Inventors: 陆一平
Original assignee: 陆一平
Priority date: 2022-01-05
Filing date: 2022-01-05
Publication date: 2023-07-13

Abstract

Composition of a surface microstructure (2) of a wound dressing (1). The main body is a dressing (1), comprising a non-woven polymer base material, the surface of which comprises a microstructure (2) formed by stacking at least one metal oxide supporter (21) and two or more nano metal particles (22, 23). The microstructure (2) comprises an inner surface layer which is implanted into the structure of the wound dressing (1) by means of vacuum sputtering and which is thus distributed in the dressing (1). In severe bacterial infection, the dressing (1) can automatically accelerate conversion of hydrogen peroxide into hydroxyl free radicals and superoxide free radicals, so that the sterilization effect is improved. When the amount of bacteria is reduced, the dressing (1) can automatically react to accelerate conversion of hydrogen peroxide into water and small-molecular oxygen, so that proliferation of cells and ends of blood vessels and wound healing are accelerated. The microstructure (2) generates a perfect disc-shaped surface plasma resonance shielding layer (3) to block invasion of external bacteria.

Description

Composition of surface microstructure of a wound dressing

technical field

The present invention is an innovative design related to the composition of the surface microstructure of the wound dressing. Ability, wound healing ability, and the technical field of a material surface microstructure with high efficiency to block bacteria from invading wounds.

Background technique

The structural design of existing wound dressings mostly uses a single-function structural design, such as using silver nanoparticles to produce an antibacterial effect, or using gold nanoparticles to produce a repairing function. However, wound healing includes three levels, one is to kill the bacteria in the wound, the other is to allow the wound to recover, and at the same time prevent the continuous invasion of bacteria in the environment.

technical problem

Silver ions or silver nanoparticles can achieve antibacterial effects, but their antibacterial properties will damage cells and hinder the recovery of wounds. At the same time, nanosilver is not a relatively breathable and loose dressing for tissues, and has an additional function of blocking bacteria. In addition, in the past experience, gold nanoparticles have the function of creating small molecule oxygen and accelerating wound repair. However, gold nanoparticles do not have obvious antibacterial properties, and at the same time, they cannot prevent external bacteria from invading wound tissue.

technical solution

The focus of the present invention is to use a single microstructure, which has three functions of killing bacteria on the wound, assisting cell proliferation to accelerate wound healing, and blocking bacteria from invading the wound on a relatively loose dressing tissue, and can be used at the same time. reached in a state of equilibrium.

Specifically, the present invention provides a composition of wound dressing surface microstructure, the main body is a dressing, its structure includes a non-woven polymer base material, and its surface includes at least one metal oxide carrier and at least two or more nano-metal particles The microstructure is stacked, and the microstructure includes being implanted into the structure of the wound dressing by vacuum sputtering, and dispersed on the inner surface of the dressing. When the bacterial infection is severe, the dressing of the present invention will automatically increase the speed at which hydrogen peroxide is converted into hydroxyl radicals and superoxide free radicals, so that the bactericidal effect is improved. When the amount of bacteria becomes less, the dressing of the present invention will automatically react and accelerate The speed at which hydrogen peroxide is converted into water and small molecule oxygen accelerates cell and blood vessel terminal proliferation and wound recovery. In addition, the microstructure designed in the present invention will produce an excellent disk-shaped surface plasmon resonance shielding layer to prevent the invasion of external bacteria, and thus obtain unprecedented innovation and progress.

Description of drawings

Fig. 1 is a schematic cross-sectional view of the surface microstructure of the wound dressing of the present invention;

Fig. 2 is the schematic diagram that the present invention carries out bactericidal function;

Fig. 3 is a schematic diagram of the repair function of the present invention;

FIG. 4 is a schematic cross-sectional view of forming a surface plasmon resonance shielding layer according to the present invention.

1. Dressing; 2. Microstructure; 21. Metal oxide carrier; 22, 23. Nano metal particles; 3. Surface plasmon resonance shielding layer.

BEST MODE FOR CARRYING OUT THE INVENTION

The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

Please refer to Fig. 1 first, the present invention is a composition of the surface microstructure of a wound dressing, the main body is a dressing 1, its structure includes a non-woven polymer base material, and its surface has at least one metal oxide carrier 21, such as titanium dioxide etc., and at least two or more nano-metal particles 22, 23, such as gold, silver, copper, etc., are stacked to form a microstructure 2. , and spread on the inner surface of dressing 1.

Take the example shown in Fig. 2, when the bacterial infection of the wound is serious, the concentration of hydrogen peroxide will be increased automatically, and the metal oxide carrier 21 of the microstructure 2 in the dressing 1 of the present invention will release electrons, which will interact with the excess in the wound. Hydrogen oxidation forms free radicals, and at the same time captures electrons from the composite nano-metal particles 22, 23, which improves the bactericidal effect; and when the amount of bacteria decreases, as shown in Figure 3, the reaction speed of hydrogen peroxide into free radicals is automatically reduced , the metal oxide carrier 21 of the microstructure 2 in the dressing 1 of the present invention no longer plays a positive role, and will also reduce the speed at which the carrier captures electrons from the nano-metal particles, and improve the activity of the hydrogen peroxide reduction reaction on the nano-metal surface. Therefore, under the catalysis of the hydrogen peroxide reduction reaction of the nano metal particles 22 and 23 , small molecules of oxygen and water are formed, which accelerates cell and blood vessel end proliferation and wound recovery.

In addition, please refer to FIG. 4 again. The microstructure 2 designed by the present invention is densely distributed in the entire interior of the dressing 1. Therefore, on the surface of the dressing 1, due to the interaction of different nano-metal particles 22 and 23, a disc-shaped The surface plasmon resonance shielding layer 3 has an excellent effect of blocking the invasion of external bacteria. The present invention is composed of an innovative microstructure 2 on the dressing 1, which has three functions of killing bacteria on the wound, assisting cell proliferation to accelerate wound healing, and blocking bacteria from invading the wound on the relatively loose dressing tissue. The performance in the best balanced state is of great patent value.

It should be noted that in this article, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply that there is a relationship between these entities or operations. There is no such actual relationship or order between them. Furthermore, the term "comprises", "comprises" or any other variation thereof is intended to cover a non-exclusive inclusion such that a process, method, article or apparatus comprising a set of elements includes not only those elements, but also includes elements not expressly listed. other elements of or also include elements inherent in such a process, method, article, or device.

Although the embodiments of the present invention have been shown and described, those skilled in the art can understand that various changes, modifications and substitutions can be made to these embodiments without departing from the principle and spirit of the present invention. and modifications, the scope of the invention is defined by the appended claims and their equivalents.

Claims

A composition of microstructure on the surface of a wound dressing, the main body is a dressing, its structure includes a non-woven polymer base material, and its surface is covered with dense microstructures, the microstructures are at least one metal oxide carrier and at least two or more stacked metal nanoparticles.
The composition of a wound dressing surface microstructure according to claim 1, characterized in that: the metal oxide carrier includes titanium dioxide.
The composition of a surface microstructure of a wound dressing according to claim 1, wherein the nano-metal particles include gold, silver, and copper.