CN104224726B - A kind of preparation method of traditional Chinese medicine pellet - Google Patents
A kind of preparation method of traditional Chinese medicine pellet Download PDFInfo
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- CN104224726B CN104224726B CN201310277101.9A CN201310277101A CN104224726B CN 104224726 B CN104224726 B CN 104224726B CN 201310277101 A CN201310277101 A CN 201310277101A CN 104224726 B CN104224726 B CN 104224726B
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- 239000003814 drug Substances 0.000 title claims abstract description 105
- 238000002360 preparation method Methods 0.000 title claims abstract description 48
- 239000008188 pellet Substances 0.000 title claims abstract description 25
- 239000011248 coating agent Substances 0.000 claims abstract description 67
- 238000000576 coating method Methods 0.000 claims abstract description 67
- 239000007788 liquid Substances 0.000 claims abstract description 59
- 239000007921 spray Substances 0.000 claims abstract description 37
- 238000000034 method Methods 0.000 claims abstract description 16
- 238000001802 infusion Methods 0.000 claims abstract description 13
- 238000001035 drying Methods 0.000 claims abstract description 11
- 239000000284 extract Substances 0.000 claims description 76
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 65
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 59
- 235000017276 Salvia Nutrition 0.000 claims description 58
- 240000007164 Salvia officinalis Species 0.000 claims description 49
- 239000002775 capsule Substances 0.000 claims description 34
- 229940079593 drug Drugs 0.000 claims description 33
- 239000006228 supernatant Substances 0.000 claims description 33
- 238000010348 incorporation Methods 0.000 claims description 21
- 239000000843 powder Substances 0.000 claims description 20
- 239000006286 aqueous extract Substances 0.000 claims description 19
- 239000006187 pill Substances 0.000 claims description 17
- 229920002472 Starch Polymers 0.000 claims description 16
- 238000005507 spraying Methods 0.000 claims description 16
- 239000008107 starch Substances 0.000 claims description 16
- 235000019698 starch Nutrition 0.000 claims description 16
- 238000003756 stirring Methods 0.000 claims description 16
- 239000002245 particle Substances 0.000 claims description 15
- 238000005243 fluidization Methods 0.000 claims description 14
- 238000001914 filtration Methods 0.000 claims description 12
- 239000008213 purified water Substances 0.000 claims description 12
- 238000012216 screening Methods 0.000 claims description 11
- 238000003809 water extraction Methods 0.000 claims description 10
- 239000003643 water by type Substances 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 8
- 238000005520 cutting process Methods 0.000 claims description 7
- 238000000605 extraction Methods 0.000 claims description 7
- 239000004744 fabric Substances 0.000 claims description 7
- 238000011049 filling Methods 0.000 claims description 7
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 6
- 238000007599 discharging Methods 0.000 claims description 6
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 6
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 6
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 235000005412 red sage Nutrition 0.000 claims description 6
- 238000005070 sampling Methods 0.000 claims description 5
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 4
- 229930006000 Sucrose Natural products 0.000 claims description 4
- 239000006071 cream Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 4
- 230000008569 process Effects 0.000 claims description 4
- 238000003860 storage Methods 0.000 claims description 3
- 239000005720 sucrose Substances 0.000 claims description 3
- 125000003158 alcohol group Chemical group 0.000 claims description 2
- 230000006837 decompression Effects 0.000 claims description 2
- 238000004806 packaging method and process Methods 0.000 claims description 2
- 238000010992 reflux Methods 0.000 claims description 2
- 241001072909 Salvia Species 0.000 claims 15
- 238000007710 freezing Methods 0.000 claims 1
- 230000008014 freezing Effects 0.000 claims 1
- 229940093429 polyethylene glycol 6000 Drugs 0.000 claims 1
- PJANXHGTPQOBST-VAWYXSNFSA-N Stilbene Natural products C=1C=CC=CC=1/C=C/C1=CC=CC=C1 PJANXHGTPQOBST-VAWYXSNFSA-N 0.000 description 9
- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical compound C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 description 9
- 235000021286 stilbenes Nutrition 0.000 description 9
- 241000544602 Ageratum Species 0.000 description 8
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 8
- 238000000889 atomisation Methods 0.000 description 8
- 229960003511 macrogol Drugs 0.000 description 8
- 238000004140 cleaning Methods 0.000 description 6
- 239000012141 concentrate Substances 0.000 description 6
- 239000000543 intermediate Substances 0.000 description 6
- 241000208340 Araliaceae Species 0.000 description 5
- 241000202726 Bupleurum Species 0.000 description 5
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 5
- 235000003140 Panax quinquefolius Nutrition 0.000 description 5
- 230000002567 autonomic effect Effects 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- 235000008434 ginseng Nutrition 0.000 description 5
- 239000008187 granular material Substances 0.000 description 5
- 238000009826 distribution Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 238000012377 drug delivery Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 229960004793 sucrose Drugs 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000007664 blowing Methods 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 241001529821 Agastache Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000003405 delayed action preparation Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
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- 238000002481 ethanol extraction Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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- 239000011236 particulate material Substances 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a kind of preparation method of traditional Chinese medicine pellet, methods described comprises the following steps：（1）Base ball is taken, base ball is drawn into fluidized drying seed-coating machine, base ball is fluidized completely in bed body；（2）When base ball temperature rises to 45 DEG C, start to spray into traditional Chinese medicine liquid with 120g/min speed, with the increase in ball footpath, amount of infusion is stepped up, but speed not more than 400g/min, spray finish, and can be sprayed into coating solution as needed and is coated.
Description
Technical field
The present invention relates to a kind of pharmaceutical preparation and preparation method thereof, described pharmaceutical preparation refers to medicinal granule, especially
It is granule of Chinese medicine or autonomic drug and preparation method thereof.
Background technology
The traditional preparation methods of Chinese medicine or autonomic drug particle are that Chinese medicine or autonomic drug or its extract are used into dry method or wet
The particulate material of certain particle size is made in method, for patient using when mixing in water for oral taking or swallow.Because Chinese medicine or autonomic drug medicinal extract glue
Degree is higher, the drugloading rate that the preparation methods of conventional particles has particle mostly is low, outward appearance unsightly, poor taste, the easy moisture absorption etc. ask
Topic.
Blank Pellets are the pharmaceutical carriers commonly used in preparation industry, and many commercially available capsule preparations are all on Blank Pellets
Medicine is carried, then is coated the target micropill that certain release request is made.It has good fluidity, easily loads capsule, and content uniformity is small, releases
The features such as drug stabilisation.Application of the micropill in art of pharmacy is quite varied, and as the carrier of medicine, it both can further be pressed
Tablet is made, capsule can be filled again, not only increases medicine stability, and can effectively regulating drug rate of release, as
Drug delivery system, micropill also have advantage therapeutically, and it is smaller to enteron aisle stimulation, reduces the burst effect of medicine,
Improve drug safety.
Drug delivery technologies use for many years on Blank Pellets, but tcm product is few, otherwise many Chinese medicine drug delivery technologies
Drugloading rate is few, otherwise it is unstable, otherwise poor appearance.
The present invention on the basis of existing technology, by process modification, finds a kind of load medicine skill of suitable Chinese medical extract
Art, and it is further prepared into traditional Chinese medicine pellet.
The content of the invention
The present invention provides a kind of preparation method of pharmaceutical preparation, comprises the following steps：
（1）It is Chinese medical extract or Chinese medical concrete to take weight ratio：Base ball 1：5-5：1 is standby；
（2）Feeding fluidizes：Recipe quantity base ball is drawn into fluidized drying seed-coating machine, base ball is flowed completely in bed body
Change；
（3）Initial stage carries the medicine stage：40-60 DEG C of temperature of charge is treated, is started with speed 70-120g/min hydrojets, the hydrojet
It is that Chinese medical extract or Chinese medical concrete are diluted with water obtained premix Chinese medical extract；
（4）In drug incorporation：In 40-60 DEG C of temperature of charge, with the increase in ball footpath, spouting liquid is stepped up, particle ball
Footpath is improved in gradient with hydrojet speed, until spraying obtains the particle that particle diameter is 0.5-1.8mm
The preparation method of the present invention, after spray, it can also be carried out as needed to carrying medicine micropill penetrating coating solution
Coating steps（5）, it is coated 40-60 DEG C of temperature of charge, hydrojet speed 40-300g/ml, Coating times 1-4 hours, the coating solution
Concentration is 5-25%.
Preferably, preparation method of the invention, comprises the following steps：
（1）It is Chinese medical extract or Chinese medical concrete to take weight ratio：Base ball 1：3-3：1 is standby；It is preferred that 2：1-1：1.
（2）Base ball feeding fluidizes：Set 600 ~ 1500m of air quantity3/ h, base ball is drawn into fluidized drying seed-coating machine, made
Base ball fluidizes completely in bed body；But being unable to vigorous fluidisation causes base ball to wear powder, spray gun atomized liquid can be covered with base ball
Drop is defined；
（3）Initial stage carries the medicine stage:Spray gun and atomizing pressure are debugged, enables decoction uniform atomizing into fine drop, by
Medicine decoction is pumped into spray gun by metering, sets jet and lower jet respectively as 2.0 ~ 3.0Bar and 2.5 ~ 3.5Bar, if
Determine 50 DEG C or so of temperature of charge, start hydrojet, hydrojet speed setting 120g/min after temperature of charge rises to 45 DEG C；
（4）In drug incorporation:45 ~ 55 DEG C of temperature of charge, with the increase in ball footpath, amount of infusion is stepped up, and transfusion speed is most
Height is no more than 400g/min, and air quantity is adjusted according to the fluidized state of micropill.
（5）Coating：Carry directly spray coating solution after medicine terminates to be coated, 50 DEG C of coating initial setting temperature of charge, hydrojet
Hydrojet speed can be adjusted to 80 ~ 150g/min, temperature of charge and controlled at 40 ~ 55 DEG C by speed 80g/min, coating after 20 minutes,
Transfusion speed, air quantity and temperature of charge are adjusted according to the adhesion situation of micropill；
Wherein, traditional Chinese medicine liquid is that Chinese medical concrete adds water to be formulated, and the weight ratio of Chinese medical concrete and water is 100：60-100,
It is preferred that 100:70-90, more preferably 100:75-85.
The preparation method of the present invention, is suitable for any Chinese medical extract or Chinese medical concrete, including folk prescription or compound, excellent
Salvia root P.E, stilbene ginseng QI invigorating, agastache extract etc. are selected, most preferably Salvia root P.E.
Salvia root P.E is purchased in market or is prepared by prior art, limited in order to preferably test the purpose of the present invention
Following methods prepare Salvia root P.E.
Salvia root P.E preparation method of the present invention is as follows：
（1）Red rooted salvia alcohol extracting, is filtrated to get alcohol extract, and dregs of a decoction A is standby；
（2）Dregs of a decoction A extracting in waters, filtering, obtain Aqueous extracts, dregs of a decoction B is discarded；
（3）Alcohol extract, Aqueous extracts cool standing respectively, then Aspirate supernatant is alcohol extracting supernatant, water extraction supernatant respectively；
（4）Water extraction supernatant concentration obtains water extracting liquid；
（5）Water extracting liquid is gradually added alcohol extracting supernatant, merges concentration, obtains mixed concentrated liquid；
（6）Purified water is added in mixed concentrated liquid, is concentrated after well mixed, is drying to obtain Salvia root P.E.
Preferably, the Salvia root P.E preparation method is as follows：
（1）2-7 times of red rooted salvia dosing material amount measures 50-100% ethanol, refluxing extraction about 0.5-4 hours, filters to obtain alcohol extracting
Liquid, dregs of a decoction A are standby；
（2）Above-mentioned 2-7 times of the dosing material amount of the dregs of a decoction 1 measures water, decocts about 0.5-4 hours, filtering, obtains Aqueous extracts, dregs of a decoction B is abandoned
Go；
（3）Step（1）In alcohol extract stirring 10-60 minutes, extract solution temperature is down to less than 15 DEG C in 4 hours, it is quiet
Put 6 ~ 24 hours Aspirate supernatants and obtain alcohol extracting supernatant, step（2）In Aqueous extracts stirring 10-60 minutes, will extraction in 4 hours
Liquid temperature degree is down to less than 15 DEG C, stands 6 ~ 24 hours, Aspirate supernatant obtains water extraction supernatant；
（4）Water extraction supernatant concentration obtains water extracting liquid to relative density 1.10 ~ 1.35；
（5）Water extracting liquid is gradually added step（3）Alcohol extracting supernatant, merge concentration, be concentrated under reduced pressure into relative density >=
1.20, obtain mixed concentrated liquid；
（6）Mixed concentrated liquid adds 10L ~ 100L purified waters by several times, adds 5 ~ 50L purified waters every time, merges concentration, decompression
It is 1.25 ~ 1.35 to be concentrated into 82.5 ± 2.5 DEG C of relative densities, filters while hot, obtains Salvia root P.E.
Wherein, step preferably（5）Step is gradually added after middle concentration Aqueous extracts to relative density 1.10~1.35（3）Alcohol
Put on clear liquid.
Wherein, preferred step（5）Step is gradually added after middle concentration Aqueous extracts to relative density 1.10~1.35（3）
Alcohol extracting supernatant, relative density is concentrated into as 1.25~1.35（82.5±2.5℃）Receive cream.
Most preferably, the Salvia root P.E preparation method is as follows：
The cutting red sage root is taken, adds 90 ± 0.5% 400 ± 12L of ethanol, decocts 90 ± 5min, the filtering of 200 mesh, alcohol extract, which merges, to be put
Enter to stand in tank；The dregs of a decoction carry out second and extracted, and add 500 ± 15L of water, decoct 60 ± 3min, the filtering of 200 mesh, and the dregs of a decoction discard, water
Extract, which merges, to be put into different standing tanks.Alcohol extracting mixed liquor and water mixing extract are respectively placed in different standing tanks, are stood tank and are led to
Chilled water cooling is stood, and after extract solution stirs 30 minutes, extract solution temperature is down into less than 15 DEG C in 4 hours, it is small to stand 6 ~ 24
When, draw alcohol extracting supernatant and water extraction supernatant is put into respective storage tank.First condensed water puts on clear liquid to water extracting liquid proportion
1.25~1.30（82.5±2.5℃）Between；It is gradually added alcohol extracting supernatant and further merges concentration, concentrate in concentration process
Proportion must not be less than 1.15；Be concentrated into mixed concentrated liquid proportion >=1.34, at twice add 10L purified waters, every time plus 5L (45 ±
5 DEG C), merge concentration, be concentrated into proportion 1.33~1.35（82.5±2.5℃）, filter while hot（40 mesh sieves）Obtain Salvia root P.E.
Base ball of the present invention, also referred to as blank capsule core, or medicinal fine pellet core, it is prior art, can be in market
On be commercially available, the major product in terms of medicinal fine pellet core has：Medicinal fine pellet core（Cane sugar type）, microcrystalline cellulose ball
Core, starch capsule core etc., base ball of the present invention are selected from starch base ball, Macrogol 6000 base ball, sucrose base ball, microcrystalline cellulose
One kind in plain base ball.Preferred starch base ball or Macrogol 6000 base ball, the base ball can drugloading rate it is high, spraying is easy, work
Skill is easily controlled, and is easy to industrialization.
Preparation in accordance with the present invention, gained carry medicine micropill by being processed further that salvia micro pill capsule can be made.
Medicine coating of pellets will be such as carried, sieving, obtains coating micro-pill, is fitted into blank capsules and produces the traditional Chinese medicine pellet capsule of the present invention.
In order to preferably realize the compound Salviae Miltiorrhizae extract micropill of the present invention, prescription of the present invention is preferably Salvia root P.E
20-40 parts, starch base ball 10-20 parts, Opadry 1-2 parts.It is preferred that 32 parts of Salvia root P.E, 16 parts of starch base ball, Opadry 1.5
Part.
Beneficial effects of the present invention
The micropill of the present invention, as microspheric granula, the dosage of carrier is few, single dose is small, typically each taking dosage be 0.1~
4g；Profile rule, spherical in shape or spherical, the smooth rounding in surface；Physical characteristic is good, such as good fluidity, grain graininess point
Cloth is regular, the fine and close anti-extrusion of quality, wear-resistant, density is big（Heap density is 0.6~1.3g/ml）, specific surface area it is small（Only 0.01
~0.03m2/g）, it is short to leach the time limit；These characteristics can improve the compliance of patient, and make the actual popularization of packaging technique should
With being possibly realized, so as to improve Chinese medicine or the easy moisture absorption of autonomic drug, it is unstable the problems such as；In addition, the micropill of the present invention is except can
To be used as common granule, intermediate or granule are also used as, it is filling into formulations such as capsules, additionally may be used
To be prepared into various coated preparations, sustained-release preparation, positioning release medicine preparation etc..
The advantages of Salvia root P.E of the present invention and preparation method thereof, is as follows：
The present invention Chinese medical extract condensing mode be mainly to the benefit that preparation is brought：Slightly solubility particle shows in extract
Writing improves, and stifled spray gun problem no longer occurs in drug incorporation.Extract ethanol residual level is relatively low, and production process is not further added by containing alcohol
Operation, it is ensured that product ethanol residual meets the requirements.Extract stability improves, and the production process index components rate of transform is stable.
It is the comparative experiments of different method for concentration below
Precise red rooted salvia 450g, with 4 times of amount 90% ethanol extraction 1.5h, medical filtration；The dregs of a decoction are returned with 5 times of amount water
Stream extraction 1h, filtering, obtains alcohol extract and Aqueous extracts.Each experiment parallel extraction is twice.
Experimental program one, concentration Aqueous extracts merging concentration is gradually added after first concentrating alcohol extract, cream is received to pol 86 ± 2%.
Experimental program two, after first concentrating Aqueous extracts to pol 84 ± 2%, it is gradually added alcohol extract and merges concentration, to pol 86
± 2% receives cream.
Sample source：20120823, which first concentrate alcohol extract, adds water extract concentration
20120829 first concentrate Aqueous extracts adds alcohol extract to concentrate again
1st, and sticking ratio big from 20120823 black mole bits particles knowable to the picture of flask adhesion after Salvia root P.E blowing
More serious, 20120829 it can be seen that precipitation black bits are relatively fine and than more uniform, so as to 20120829 condensing modes
Extract character is preferable.
2nd, clean respective batch flask result picture with water and can be seen that 20120823 flask black mole bits sticking ratios are serious,
It is less that the viscous wall situation of condensing mode is planted afterwards.So as to from 20120829 batch condensing modes for water cleaning performance to equipment clean compared with
It is good.
3rd, understand that 20120823 cleaning solution colors are heavier from the picture of 95% ethanol cleaning, 20120829 solution colours
It is more clear.
In summary, it is first from 20120829 batch condensing modes for Salvia root P.E Apparent character and follow-up equipment cleaning
It is optimal that alcohol extract merging condensing mode is gradually added after concentration Aqueous extracts.
Influence of the different condensing modes to Salvia root P.E size distribution
2 it can be seen that in coating picture from the graph, and the 20120823 black mole bits for having obvious bulky grain separate out, another kind concentration
Mode Salvia root P.E black bits distribution it is smaller than more uniform and particle, on Salvia root P.E on follow-up preparation influence compared with
It is small.
Size distribution is surveyed in pharmacopeia screening
Each batch Salvia root P.E medicinal extract 50 is taken respectively, is added 5 times of amount water dissolvings, is crossed 1-8 pharmacopeia sieve（Pharmacopeia sieve is folded successively
Put）, with about 500ml distilled water flushing, extract granule distribution situation in every layer of pharmacopeia sieve is observed, then uses the particle in every layer
Water rinses, and collects, and filters, and is weighed together with filter paper drying.
As above-mentioned chart understands that it was found from extract particles size and bulky grain appearance order extract character is excellent slightly suitable
Sequence is 20120829-J>20120823-J.Therefore 20120829 condensing modes are preferable.
Brief description of the drawings
Picture is tested in Fig. 1 experimentations, wherein, flask adheres to picture, second row after first row Salvia root P.E blowing
Picture after flask of water cleaning, picture after the cleaning of the ethanol of the 3rd row's flask 95%
Fig. 2 Salvia root P.Es are coated with photo
Embodiment
The present invention is further illustrated by the following examples, but not as limitation of the present invention.
Embodiment 1
The preparation of Salvia root P.E, step are as follows：
The cutting red sage root：Medicinal material visual examination, weigh, it is standby.
Medicinal material feeds intake requirement：
The cutting red sage root：The different batches cutting red sage root can be used by proper proportion collocation as needed.
Add material order：The E cutting reds sage root are first thrown when feeding intake, one decocts 90 ± 0.5% ethanol of addition, two pan-fried addition one-level RO
Water is extracted as extraction solvent.
Extraction：
One batch is made up of 2 tanks, is weighed cutting red sage root 100kg respectively by batch prescription per tank, is added 90 ± 0.5% ethanol 400
± 12L, 90 ± 5min, the filtering of 200 mesh are decocted, two tank alcohol extracts, which merge to be put into, to be stood in tank；The dregs of a decoction carry out second and extracted, and add
500 ± 15L of water, 60 ± 3min, the filtering of 200 mesh are decocted, the dregs of a decoction are discarded, and two tank Aqueous extracts, which merge, to be put into different standing tanks.
Cooling is stood：
Alcohol extracting mixed liquor and water mixing extract are respectively placed in different standing tanks, are stood tank and are led to chilled water cooling standing, carry
After taking liquid to stir 30 minutes, extract solution temperature is down to less than 15 DEG C in 4 hours, stands 6 ~ 24 hours, draws alcohol extracting supernatant
Put with water extraction supernatant into respective storage tank.
Concentration：
First condensed water puts on clear liquid to water extracting liquid proportion 1.25~1.30（82.5±2.5℃）Between；It is gradually added
E01 alcohol extractings supernatant further merges concentration, and concentrate proportion must not be less than 1.15 in concentration process；It is dense to be concentrated into E01 mixing
Contracting liquor ratio weight >=1.34,10L purified waters are added at twice, every time plus 5L (45 ± 5 DEG C), merging concentrate, and are concentrated into proportion 1.33
~1.35（82.5±2.5℃）, filter while hot（40 mesh sieves）Obtain E01 Salvia root P.Es.
Embodiment 2
Salvia micro pill capsule, it can be prepared according to following methods：
Raw material：
Salvia root P.E 32.5kg
Starch base ball 16.0kg
Opadry 85G66817 1.5kg
Preparation method is as follows：
The preparation of Salvia root P.E decoction：In Salvia root P.E input premixing tank, the purified water of 0.7 ~ 0.9 times of amount is added,
Stirring more than 30 minutes, obtains traditional Chinese medicine liquid；
Starch base ball carries medicine：Spray gun and atomizing pressure are debugged, it is fine drop to enable decoction uniform atomizing；
Feeding fluidizes：Starch base ball is sucked in fluidisation dry coationg machine, sets 600 ~ 1500m of air quantity3/ h, base ball is set to exist
Fluidized completely in bed body, but be unable to vigorous fluidisation and cause base ball to wear powder, can cover spray gun atomized drop by base ball is defined；
Will premix extract by metering be pumped into spray gun, set respectively jet and lower jet as 2.0 ~ 3.0Bar with
2.5~3.5Bar；Initial stage carries the medicine stage, sets 50 DEG C or so of temperature of charge, starts hydrojet after temperature of charge rises to 45 DEG C, sprays
Liquid speed degree sets 70 ~ 120g/min；In drug incorporation, 45 ~ 55 DEG C of temperature of charge, with the increase in ball footpath, amount of infusion is stepped up,
Transfusion speed not more than 400g/min, air quantity are adjusted according to the fluidized state of micropill；In drug incorporation, if necessary from
Sample tap sampling observes the adhesion of micropill and plays a powder situation, and adjusts transfusion speed, wind with powder situation is played according to the adhesion of micropill
Amount and temperature of charge；
Coating：Opadry 85G66817 and purified water are taken, is stirred and evenly mixed, stirring is no less than 45 minutes, obtains 18% coating
Liquid is standby；Carry directly spray coating solution after medicine terminates to be coated, 50 DEG C of coating initial setting temperature of charge, hydrojet speed 40 ~
Hydrojet speed can be adjusted to 80 ~ 150g/min, temperature of charge and controlled at 40 ~ 55 DEG C by 80g/min, coating after 20 minutes, according to
The adhesion situation adjustment transfusion speed of micropill, air quantity and temperature of charge, after coating terminates, are cooled to 35 DEG C, discharging；
Coated pellet is screened：Intermediate coated pellet is screened, screen cloth net footpath is 1.8mm, and screenings is salvia micro pill；Screening institute
Obtain salvia micro pill accounting example and be not less than 90%；
Capsule is filled：The salvia micro pill that will be screened, capsule is filled with capsule filling machine, is produced.
Embodiment 3
Carry the preparation of medicine micropill
Base ball feeding fluidizes：Set air quantity 600m3/ h, base ball is drawn into fluidized drying seed-coating machine, makes base ball in bed
Fluidize completely in vivo；But being unable to vigorous fluidisation causes base ball to wear powder；
Initial stage carries the medicine stage:Spray gun is debugged, allows to atomization well, traditional Chinese medicine liquid is pumped into spray gun by metering,
Jet and lower jet are set respectively as 2.0Bar and 2.5Bar, are set 50 DEG C or so of temperature of charge, are treated that temperature of charge rises to 45
Start hydrojet, hydrojet speed setting 70g/min after DEG C;
In drug incorporation:50 DEG C of temperature of charge, with the increase in ball footpath, amount of infusion is stepped up, and transfusion speed is not more than
400g/min is crossed, air quantity is adjusted according to the fluidized state of micropill.
Coating：Carry directly spray coating solution after medicine terminates to be coated, 50 DEG C of coating initial setting temperature of charge, hydrojet speed
40g/min, hydrojet speed can be adjusted to 80g/min, temperature of charge and controlled at 40 DEG C by coating after 20 minutes, according to the viscous of micropill
Even situation adjustment transfusion speed, air quantity and temperature of charge；
Wherein, traditional Chinese medicine liquid is that Chinese medical concrete adds water to be formulated, and the weight ratio of Chinese medical concrete and water is 100：90.Implement
Example 4
Carry the preparation of medicine micropill
Base ball feeding fluidizes：Set air quantity 1500m3/ h, base ball is drawn into fluidized drying seed-coating machine, makes base ball in bed
Fluidize completely in vivo；
Initial stage carries the medicine stage:Spray gun is debugged, allows to atomization well, traditional Chinese medicine liquid is pumped into spray gun by metering,
Jet and lower jet are set respectively as 3.0Bar and 3.5Bar, are set 50 DEG C or so of temperature of charge, are treated that temperature of charge rises to 45
Start hydrojet, hydrojet speed setting 120g/min after DEG C;
In drug incorporation:55 DEG C of temperature of charge, with the increase in ball footpath, amount of infusion is stepped up, and transfusion speed is not more than
400g/min is crossed, air quantity is adjusted according to the fluidized state of micropill.
Coating：Carry directly spray coating solution after medicine terminates to be coated, 50 DEG C of coating initial setting temperature of charge, hydrojet speed
80g/min, coating can adjust hydrojet speed after 20 minutes to 150g/min, and temperature of charge is controlled at 55 DEG C, according to micropill
Adhesion situation adjusts transfusion speed, air quantity and temperature of charge；
Wherein, traditional Chinese medicine liquid is that Chinese medical concrete adds water to be formulated, and the weight ratio of Chinese medical concrete and water is 100：70.Implement
Example 5
Carry the preparation of medicine micropill
Base ball feeding fluidizes：Set air quantity 1500m3/ h, base ball is drawn into fluidized drying seed-coating machine, makes base ball in bed
Fluidize completely in vivo；
Initial stage carries the medicine stage:Spray gun is debugged, allows to atomization well, traditional Chinese medicine liquid is pumped into spray gun by metering,
Jet and lower jet are set respectively as 3.0Bar and 3.5Bar, are set 50 DEG C or so of temperature of charge, are treated that temperature of charge rises to 45
Start hydrojet, hydrojet speed setting 120g/min after DEG C;
In drug incorporation:55 DEG C of temperature of charge, with the increase in ball footpath, amount of infusion is stepped up, and transfusion speed is not more than
400g/min is crossed, air quantity is adjusted according to the fluidized state of micropill.
Coating：Carry directly spray coating solution after medicine terminates to be coated, 50 DEG C of coating initial setting temperature of charge, hydrojet speed
80g/min, coating can adjust hydrojet speed after 20 minutes to 150g/min, and temperature of charge is controlled at 55 DEG C, according to micropill
Adhesion situation adjusts transfusion speed, air quantity and temperature of charge；
Wherein, Chinese medical extract is Salvia root P.E, and base ball is starch base ball, and both part by weight are 2:1, traditional Chinese medicine liquid
It is that Chinese medical concrete adds water to be formulated, the weight ratio of Chinese medical concrete and water is 100：82.
Embodiment 6
Carry the preparation of medicine micropill
Base ball feeding fluidizes：Set air quantity 1500m3/ h, base ball is drawn into fluidized drying seed-coating machine, makes base ball in bed
Fluidize completely in vivo；But being unable to vigorous fluidisation causes base ball to wear powder；
Initial stage carries the medicine stage:Spray gun uses 0.2mm pad, debugs spray gun, allows to atomization well, traditional Chinese medicine liquid is led to
Cross metering and be pumped into spray gun, set jet and lower jet respectively as 3.0Bar and 3.5Bar, 50 DEG C of left sides of setting temperature of charge
The right side, start hydrojet, hydrojet speed setting 120g/min after temperature of charge rises to 45 DEG C;In drug incorporation:55 DEG C of temperature of charge,
With the increase in ball footpath, amount of infusion is stepped up, transfusion speed not more than 400g/min, and air quantity is according to the fluidized state of micropill
It is adjusted.
Coating：Carry directly spray coating solution after medicine terminates to be coated, 50 DEG C of coating initial setting temperature of charge, hydrojet speed
80g/min, coating can adjust hydrojet speed after 30 minutes to 150g/min, and temperature of charge is controlled at 55 DEG C, according to micropill
Adhesion situation adjusts transfusion speed, air quantity and temperature of charge；
Wherein, Chinese medical extract is Salvia root P.E, and base ball is sucrose base ball, and both part by weight are 1:1, traditional Chinese medicine liquid
It is that Chinese medical concrete adds water to be formulated, the weight ratio of Chinese medical concrete and water is 100：90.
Embodiment 7
Salvia micro pill capsule, it can be prepared according to following methods：
Raw material：
Salvia root P.E 32.5kg
Starch base ball 16.0kg
Opadry 85G66817 1.5kg
Preparation method is as follows：
The preparation of Salvia root P.E decoction：In Salvia root P.E input premixing tank, the purified water of 0.82 times of weight is added, is stirred
Mix more than 30 minutes, obtain traditional Chinese medicine liquid；
Starch base ball carries medicine：Spray gun is debugged, it is good to allow to atomization；Feeding fluidizes：Starch base ball is sucked into fluidized drying
In seed-coating machine, air quantity 1000m is set3/ h, base ball is fluidized completely in bed body, but be unable to vigorous fluidisation and cause base ball to wear
Powder；Premix extract is pumped into spray gun by metering, sets jet and lower jet respectively as 2.5Bar and 3Bar；Initial stage
The medicine stage is carried, sets 50 DEG C or so of temperature of charge, starts hydrojet, hydrojet speed setting 120g/ after temperature of charge rises to 45 DEG C
min；In drug incorporation, 50 DEG C of temperature of charge, with the increase in ball footpath, amount of infusion is stepped up, and transfusion speed is not more than
400g/min, air quantity are adjusted according to the fluidized state of micropill；In drug incorporation, micropill from being sampled if necessary from sample tap
Adhesion and play a powder situation, and according to the adhesion of micropill and play powder situation adjustment transfusion speed, air quantity and a temperature of charge；
Coating：Opadry 85G66817 and purified water are taken, is stirred and evenly mixed, stirring is no less than 45 minutes, obtains 18% coating
Liquid is standby；Carry directly spray coating solution after medicine terminates to be coated, 50 DEG C of coating initial setting temperature of charge, hydrojet speed 80g/
Min, coating can adjust hydrojet speed after 20 minutes to 100g/min, and temperature of charge is controlled at 50 DEG C, according to the adhesion of micropill
Situation adjusts transfusion speed, air quantity and temperature of charge, after coating terminates, is cooled to 35 DEG C, discharging；
Coated pellet is screened：Intermediate coated pellet is screened, screen cloth net footpath is 1.8mm, and screenings is salvia micro pill；Screening institute
Obtain salvia micro pill accounting example and be not less than 90%；
Capsule is filled：The salvia micro pill that will be screened, capsule is filled with capsule filling machine, is produced.
The bupleurum extract micro pill capsule of embodiment 8,
Prescription：
Bupleurum extract 1.40kg
Microcrystalline cellulose base ball 1.60kg
Opadry 85G66817 0.10kg
Preparation method is as follows：
The preparation of bupleurum extract decoction：In bupleurum extract input premixing tank, the purified water of 0.9 times of weight is added, is stirred
Mix more than 30 minutes, obtain traditional Chinese medicine liquid；
Microcrystalline cellulose base ball carries medicine：Spray gun is debugged, it is good to allow to atomization；Feeding fluidizes：By microcrystalline cellulose base ball
In suction fluidisation dry coationg machine, air quantity 1200m is set3/ h, base ball is fluidized completely in bed body, but be unable to vigorous fluidisation and make
Powder has been worn into base ball；Will premix extract by metering be pumped into spray gun, set respectively jet and lower jet as
2.2Bar and 3.2Bar；Initial stage carries the medicine stage, sets 50 DEG C or so of temperature of charge, starts to spray after temperature of charge rises to 45 DEG C
Liquid, hydrojet speed setting 100g/min；In drug incorporation, 50 DEG C of temperature of charge, with the increase in ball footpath, amount of infusion is stepped up,
Transfusion speed not more than 400g/min, air quantity are adjusted according to the fluidized state of micropill；In drug incorporation, if necessary from
Sample tap sampling observes the adhesion of micropill and plays a powder situation, and adjusts transfusion speed, wind with powder situation is played according to the adhesion of micropill
Amount and temperature of charge；
Coating：Opadry 85G66817 and purified water are taken, is stirred and evenly mixed, stirring is no less than 45 minutes, obtains 18% coating
Liquid is standby；Carry directly spray coating solution after medicine terminates to be coated, 50 DEG C of coating initial setting temperature of charge, hydrojet speed 80g/
Min, coating can adjust hydrojet speed after 20 minutes to 100g/min, and temperature of charge is controlled at 50 DEG C, according to the adhesion of micropill
Situation adjusts transfusion speed, air quantity and temperature of charge, after coating terminates, is cooled to 35 DEG C, discharging；
Coated pellet is screened：Intermediate coated pellet is screened, screen cloth net footpath is 1.8mm, and screenings is radix bupleuri micropill；Screening institute
Obtain radix bupleuri micropill accounting example and be not less than 90%；
Capsule is filled：The radix bupleuri micropill that will be screened, capsule is filled with capsule filling machine, is produced.
The stilbene of embodiment 9 joins QI invigorating micro pill capsule,
Prescription：
Stilbene ginseng QI invigorating mixed extract 1.25kg
Macrogol 6000 base ball 3.75kg
Opadry 85G66817 0.20kg
Preparation method is as follows：
Stilbene joins the preparation of QI invigorating extract decoction：In stilbene ginseng QI invigorating extract input premixing tank, the pure of 0.7 times of weight is added
Change water, stir more than 30 minutes, obtain traditional Chinese medicine liquid；
Macrogol 6000 base ball carries medicine：Spray gun is debugged, it is good to allow to atomization；Feeding fluidizes：By Macrogol 6000
In base ball suction fluidisation dry coationg machine, air quantity 900m is set3/ h, base ball is fluidized completely in bed body, but can not acutely flow
Change causes base ball to wear powder；Will premix extract by metering be pumped into spray gun, set respectively jet and lower jet as
2.2Bar and 3.2Bar；Initial stage carries the medicine stage, sets 50 DEG C or so of temperature of charge, starts to spray after temperature of charge rises to 40 DEG C
Liquid, hydrojet speed setting 80g/min；In drug incorporation, 50 DEG C of temperature of charge, with the increase in ball footpath, amount of infusion is stepped up, defeated
Liquid speed degree not more than 400g/min, air quantity are adjusted according to the fluidized state of micropill；In drug incorporation, if necessary from taking
The sampling of sample mouth observes the adhesion of micropill and plays a powder situation, and adjusts transfusion speed, air quantity with powder situation is played according to the adhesion of micropill
And temperature of charge；
Coating：Opadry 85G66817 and purified water are taken, is stirred and evenly mixed, stirring is no less than 45 minutes, obtains 18% coating
Liquid is standby；Carry directly spray coating solution after medicine terminates to be coated, 50 DEG C of coating initial setting temperature of charge, hydrojet speed 80g/
Min, coating can adjust hydrojet speed after 20 minutes to 100g/min, and temperature of charge is controlled at 50 DEG C, according to the adhesion of micropill
Situation adjusts transfusion speed, air quantity and temperature of charge, after coating terminates, is cooled to 35 DEG C, discharging；
Coated pellet is screened：Intermediate coated pellet is screened, screen cloth net footpath is 1.8mm, and screenings is that stilbene joins QI invigorating micropill；Sieve
Choosing gained stilbene ginseng QI invigorating micropill accounting example is not less than 90%；
Capsule is filled：The stilbene screened is joined into QI invigorating micropill, capsule is filled with capsule filling machine, produces.
Embodiment 10
Ageratum micro pill capsule,
Prescription：
Ageratum mixed extract 6.25kg
Macrogol 6000 base ball 6.25kg
Opadry 85G66817 0.40kg
Preparation method is as follows：
The preparation of ageratum extract decoction：In ageratum extract input premixing tank, the pure of 0.8 times of weight is added
Change water, stir more than 30 minutes, obtain traditional Chinese medicine liquid；
Macrogol 6000 base ball carries medicine：Spray gun is debugged, it is good to allow to atomization；Feeding fluidizes：By Macrogol 6000
In base ball suction fluidisation dry coationg machine, air quantity 900m is set3/ h, base ball is fluidized completely in bed body, but can not acutely flow
Change causes base ball to wear powder；Will premix extract by metering be pumped into spray gun, set respectively jet and lower jet as
2.2Bar and 3.2Bar；Initial stage carries the medicine stage, sets 50 DEG C or so of temperature of charge, starts to spray after temperature of charge rises to 40 DEG C
Liquid, hydrojet speed setting 80g/min；In drug incorporation, 50 DEG C of temperature of charge, with the increase in ball footpath, amount of infusion is stepped up, defeated
Liquid speed degree not more than 400g/min, air quantity are adjusted according to the fluidized state of micropill；In drug incorporation, if necessary from taking
The sampling of sample mouth observes the adhesion of micropill and plays a powder situation, and adjusts transfusion speed, air quantity with powder situation is played according to the adhesion of micropill
And temperature of charge；
Coating：Opadry 85G66817 and purified water are taken, is stirred and evenly mixed, stirring is no less than 45 minutes, obtains 18% coating
Liquid is standby；Carry directly spray coating solution after medicine terminates to be coated, 50 DEG C of coating initial setting temperature of charge, hydrojet speed 80g/
Min, coating can adjust hydrojet speed after 20 minutes to 100g/min, and temperature of charge is controlled at 50 DEG C, according to the adhesion of micropill
Situation adjusts transfusion speed, air quantity and temperature of charge, after coating terminates, is cooled to 35 DEG C, discharging；
Coated pellet is screened：Intermediate coated pellet is screened, screen cloth net footpath is 1.8mm, and screenings is ageratum micropill；Sieve
Choosing gained ageratum micropill accounting example is not less than 90%；
Capsule is filled：The ageratum micropill that will be screened, capsule is filled with capsule filling machine, is produced.Above-described embodiment
Described in ageratum, bupleurum extract, stilbene ginseng QI invigorating extract prepared according to prior art.
Claims (9)
- A kind of 1. preparation method of pharmaceutical preparation, it is characterised in that：Comprise the following steps：(1) it is Chinese medical extract or Chinese medical concrete to take weight ratio：Base ball 1：3-3：1 is standby；(2) feeding fluidizes：Recipe quantity base ball is drawn into fluidized drying seed-coating machine, base ball is fluidized completely in bed body；(3) initial stage carries the medicine stage：Treat 40-60 DEG C of temperature of charge, start with speed 70-120g/min hydrojets, the hydrojet be by The premix Chinese medical extract that Chinese medical extract or Chinese medical concrete are diluted with water to obtain is atomized into fine drop, is coated on base ball table Face；The weight of Chinese medical concrete and water ratio is 100：60-100；(4) in drug incorporation：In 40-60 DEG C of temperature of charge, with the increase in ball footpath, spouting liquid is stepped up, particle ball footpath with Hydrojet speed improves in gradient, until spraying obtains the particle that particle diameter is 0.5-1.8mm；Described Chinese medical extract is Salvia root P.E；Described Salvia root P.E has following methods to be prepared：(1) the rudimentary alcohol extracting of red rooted salvia, is filtrated to get alcohol extract, and dregs of a decoction A is standby；(2) dregs of a decoction A extracting in waters, filtering, obtain Aqueous extracts, dregs of a decoction B is discarded；(3) alcohol extract, Aqueous extracts cool standing respectively, then Aspirate supernatant is alcohol extracting supernatant, water extraction supernatant respectively；(4) water extraction supernatant concentration obtains water extracting liquid；(5) water extracting liquid is gradually added alcohol extracting supernatant, merges concentration, obtains mixed concentrated liquid；(6) mixed concentrated liquid adds purified water, is concentrated after well mixed, produces Salvia root P.E.
- 2. preparation method as claimed in claim 1, is characterised by：Also include (5) packaging technique, after step (4) load medicine terminates, Coating solution spraying is directly sprayed, is coated 30-60 DEG C of temperature of charge, hydrojet speed 40-300g/min is Coating times 1-4 hours, described Coating solution concentration is 5-25%.
- 3. preparation method as claimed in claim 1 or 2, it is characterised in that：Comprise the following steps：(1) it is Chinese medical extract or Chinese medical concrete to take weight ratio：Base ball 1：3-3：1；(2) feeding fluidizes：Recipe quantity base ball is sucked in fluidisation dry coationg machine, sets air quantity 600-1500m3/ h, base ball is set to exist Fluidized completely in bed body, but be unable to vigorous fluidisation, can cover spray gun atomized drop by base ball is defined；(3) initial stage carries the medicine stage:Premix extract is pumped into spray gun by metering, spray gun and atomizing pressure is debugged, makes pre- Mixed extract can uniform atomizing be tiny drop, set jet and lower jet respectively as 2.0-3.0Bar and 2.5- 3.5Bar, 50 DEG C of temperature of charge is set, start hydrojet, hydrojet speed setting 60-120g/min after temperature of charge rises to 45 DEG C；(4) in drug incorporation:45-55 DEG C of temperature of charge, with the increase in ball footpath, amount of infusion is stepped up, and transfusion speed highest is not More than 400g/min, air quantity is adjusted according to the fluidized state of micropill；(5) it is coated：Carry directly spray coating solution after medicine terminates to be coated, 50 DEG C of coating initial setting temperature of charge, hydrojet speed 40-80g/min, coating can adjust hydrojet speed to 80-150g/min after 20 minutes, and temperature of charge control is at 40-55 DEG C, root Transfusion speed, air quantity and temperature of charge are adjusted according to the adhesion situation of micropill.
- 4. preparation method as claimed in claim 1, it is characterised in that：Described Salvia root P.E is prepared into by following methods Arrive：(1) 2-7 times of red rooted salvia dosing material amount measures 50-100% ethanol, refluxing extraction 0.5-4 hours, filters to obtain alcohol extract, medicine Slag A is standby；(2) above-mentioned 2-7 times of dregs of a decoction A dosing materials amount measures water, decocts 0.5-4 hours, filtering, obtains Aqueous extracts, dregs of a decoction B is discarded；(3) alcohol extract cooling is stood in step (1), extract solution mixing time 10-60 minutes, drops extract solution temperature in 4 hours To less than 15 DEG C, stand 6~24 hours Aspirate supernatants and obtain alcohol extracting supernatant, the cooling of step (2) Aqueous extracts is stood, and extract solution stirs Mix minute time 10-60, extract solution temperature is down to less than 15 DEG C in 4 hours, stand 6~24 hours, Aspirate supernatant obtains water Put on clear liquid；(4) water extraction supernatant concentration obtains water extracting liquid to relative density 1.10~1.35；(5) water extracting liquid is gradually added step (3) alcohol extracting supernatant, merges concentration, is concentrated under reduced pressure into relative density >=1.20, Obtain mixed concentrated liquid；(6) mixed concentrated liquid adds 10L~100L purified waters by several times, adds 5~50L purified waters every time, merges concentration, and decompression is dense It is 1.25~1.35 to be reduced to 82.5 ± 2.5 DEG C of relative densities, filters while hot, obtains Salvia root P.E.
- 5. preparation method as claimed in claim 3, it is characterised in that：Aqueous extracts are concentrated in step (5) to relative density 1.10 Step (3) alcohol extracting supernatant is gradually added after~1.35.
- 6. preparation method as claimed in claim 5, it is characterised in that：Aqueous extracts are concentrated in step (5) to relative density 1.10 Be gradually added step (3) alcohol extracting supernatant after~1.35, determine at 82.5 ± 2.5 DEG C, be concentrated into relative density for 1.25~ 1.35 receive cream.
- 7. preparation method as claimed in claim 1, it is characterised in that：Described base ball is selected from starch base ball, polyethylene glycol 6000 base balls, sucrose base ball, one kind in microcrystalline cellulose base ball.
- 8. preparation method as claimed in claim 1, it is characterised in that described Salvia root P.E is obtained by following methods 's：The cutting red sage root is taken, adds 90 ± 0.5% 400 ± 12L of ethanol, decocts 90 ± 5min, the filtering of 200 mesh, alcohol extract merging is put into quiet Put in tank；The dregs of a decoction carry out second and extracted, and add 500 ± 15L of water, decoct 60 ± 3min, the filtering of 200 mesh, and the dregs of a decoction discard, Aqueous extracts Merging is put into different standing tanks；Alcohol extracting mixed liquor and water mixing extract are respectively placed in different standing tanks, stand the logical freezing of tank Water cooling is stood, and after extract solution stirs 30 minutes, extract solution temperature is down into less than 15 DEG C in 4 hours, stands 6~24 hours, Draw alcohol extracting supernatant and water extraction supernatant to put into respective storage tank, determine at 82.5 ± 2.5 DEG C, first condensed water puts on clear liquid extremely Between water extracting liquid proportion 1.25~1.30；It is gradually added alcohol extracting supernatant and further merges concentration, is concentrated in concentration process Liquor ratio weight must not be less than 1.15；Mixed concentrated liquid proportion >=1.34 are concentrated into, add 10L purified waters at twice, at 45 ± 5 DEG C, Every time plus water 5L, merge concentration, determine at 82.5 ± 2.5 DEG C, be concentrated into proportion 1.33~1.35, filter while hot, cross 40 mesh sieves Obtain Salvia root P.E.
- 9. preparation method as claimed in claim 8, gained micropill is by being processed further that salvia micro pill capsule, the pellet is made Join micro pill capsule, formula is as follows：Salvia root P.E 20-40 partsStarch base ball 10-20 partsOpadry 85G66817 1-2 partsPreparation method is as follows：The preparation of Salvia root P.E decoction：In Salvia root P.E input premixing tank, the purified water of 0.2~2 times of amount, stirring 30 are added More than minute, traditional Chinese medicine liquid is obtained；Starch base ball carries medicine：Spray gun and atomizing pressure are debugged, enables decoction uniform atomizing into fine drop；Feeding fluidizes：Starch base ball is sucked in fluidisation dry coationg machine, sets 600~1500m of air quantity3/ h, make base ball in bed body Interior fluidisation completely, can cover spray gun atomized drop by base ball and be defined；By premixed drug solutions by metering be pumped into spray gun, set respectively jet and lower jet as 2.0~3.0Bar and 2.5~ 3.5Bar；Initial stage carries the medicine stage, sets 50 DEG C of temperature of charge, starts hydrojet after temperature of charge rises to 45 DEG C, hydrojet speed is set Fixed 70~120g/min；In drug incorporation, 45~55 DEG C of temperature of charge, with the increase in ball footpath, amount of infusion is stepped up, transfusion speed Not more than 400g/min is spent, air quantity is adjusted according to the fluidized state of micropill；In drug incorporation, if necessary from sample tap Sampling observes the adhesion of micropill and plays a powder situation, and adjusts transfusion speed, air quantity and thing with powder situation is played according to the adhesion of micropill Material temperature degree；Coating：Opadry 85G66817 and purified water are taken, is stirred and evenly mixed, stirring is no less than 45 minutes, obtains 18% coating solution It is standby；Carry directly spray coating solution after medicine terminates to be coated, 50 DEG C of coating initial setting temperature of charge, 40~80g/ of hydrojet speed Min, coating can adjust hydrojet speed after 20 minutes to 80~150g/min, and temperature of charge is controlled at 40~55 DEG C, according to micro- The adhesion situation adjustment transfusion speed of ball, air quantity and temperature of charge, after coating terminates, are cooled to 35 DEG C, discharging；Coated pellet is screened：Intermediate coated pellet is screened, screen cloth net footpath is 1.8mm, and screenings is salvia micro pill；Screening gained is red Join micropill accounting example and be not less than 90%；Capsule is filled：The salvia micro pill that will be screened, capsule is filled with capsule filling machine, is produced.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0632741A (en) * | 1992-07-15 | 1994-02-08 | Mitsubishi Petrochem Co Ltd | Agent for preventing and treating microbism of fishes and its use |
| CN1596917A (en) * | 2003-09-16 | 2005-03-23 | 成都尚科药业有限公司 | Preparation method of compound red-rooted salvia micro pill |
| CN1692914A (en) * | 2004-05-08 | 2005-11-09 | 成都康弘科技实业（集团）有限公司 | Traditional Chinese medicine small pills for treating coronary heart disease and angina pectoris, and its prepn. method |
| CN1853670B (en) * | 2005-03-29 | 2010-12-15 | 贵阳云岩西创药物科技开发有限公司 | Coronary heart Danshen root micropellets and preparation thereof |
| CN101091725A (en) * | 2006-06-23 | 2007-12-26 | 天津天士力制药股份有限公司 | Chinese traditional medicine grains and preparation method |
| CN101439087B (en) * | 2007-11-22 | 2012-03-28 | 天津天士力制药股份有限公司 | Chinese medicine granule containing salvia root extract and preparation method thereof |
| CN101439041B (en) * | 2007-11-22 | 2012-01-04 | 天津天士力制药股份有限公司 | Chinese medicine granule containing breviscapine and preparation method thereof |
| CN101596240B (en) * | 2009-07-06 | 2011-12-28 | 沈阳亿灵医药科技有限公司 | Shuangdan micro pill and preparation method thereof |
| CN102114072B (en) * | 2009-12-31 | 2012-12-26 | 丽珠医药集团股份有限公司 | Red sage root extract sustained-release micropills and preparation method and application thereof |
| CN101773546A (en) * | 2010-03-02 | 2010-07-14 | 沈阳药科大学 | Salvia miltiorrhiza effective-component synchronous site-specific drug delivery mini-pill and preparation method thereof |
| CN102133194B (en) * | 2011-03-11 | 2013-11-13 | 中国药科大学 | Preparation method and application of tanshinone II A solid dispersion pellets |
-
2013
- 2013-07-03 CN CN201310277101.9A patent/CN104224726B/en active Active
-
2014
- 2014-06-16 CN CN201410270961.4A patent/CN104224727B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102028746A (en) * | 2009-09-29 | 2011-04-27 | 天津天士力现代中药资源有限公司 | Drug for treating coronary heart disease and extraction method |
Non-Patent Citations (2)
| Title |
|---|
| 丹参的提前精制工艺的研究;蔡韡韡;《中华中医药学刊》;20121130;第30卷(第11期);第2565页右栏第一段，2569页"4.1 确定丹参的提取精制工艺" * |
| 离心造粒法制备复方丹参微丸;袁亮 等;《中国实验方剂学杂志》;20100531;第16卷(第5期);第11页左栏第1段，"1.2 试药"，"2.1 空白丸芯的制备"，"2.2 复方丹参微丸的制备"，第11页"2.4 微丸处方和工艺因素研究" * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104224727B (en) | 2018-04-03 |
| CN104224726A (en) | 2014-12-24 |
| CN104224727A (en) | 2014-12-24 |
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