CN104224446A - Alginate adhesive bandage and manufacturing method of alginate adhesive bandage - Google Patents

Alginate adhesive bandage and manufacturing method of alginate adhesive bandage Download PDF

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Publication number
CN104224446A
CN104224446A CN201410447318.4A CN201410447318A CN104224446A CN 104224446 A CN104224446 A CN 104224446A CN 201410447318 A CN201410447318 A CN 201410447318A CN 104224446 A CN104224446 A CN 104224446A
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CN
China
Prior art keywords
alginate
bandage
woven fabrics
glue
fabric
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Granted
Application number
CN201410447318.4A
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Chinese (zh)
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CN104224446B (en
Inventor
韩士兵
徐琳淞
王建平
康晨
刘勤华
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CHANGZHOU HAOAN BIOLOGICAL SCIENCE & TECHNOLOGY Co Ltd
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CHANGZHOU HAOAN BIOLOGICAL SCIENCE & TECHNOLOGY Co Ltd
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Priority to CN201410447318.4A priority Critical patent/CN104224446B/en
Publication of CN104224446A publication Critical patent/CN104224446A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/02Adhesive bandages or dressings
    • A61F13/023Adhesive bandages or dressings wound covering film layers without a fluid retention layer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/02Adhesive bandages or dressings
    • A61F13/0259Adhesive bandages or dressings characterised by the release liner covering the skin adhering layer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/02Adhesive bandages or dressings
    • A61F13/0276Apparatus or processes for manufacturing adhesive dressings or bandages
    • A61F13/0289Apparatus or processes for manufacturing adhesive dressings or bandages manufacturing of adhesive dressings

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Manufacturing & Machinery (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The invention discloses an alginate adhesive bandage and a manufacturing method of the alginate adhesive bandage. The adhesive bandage consists of a waterproof fabric, a medical acrylic glue water layer, a 100-percent alginate non-woven fabric and protection paper, wherein the weft elasticity of the waterproof fabric is greater than 150 percent, the medical acrylic glue water layer is arranged at one side of the waterproof fabric in a coating way, the 100-percent alginate non-woven fabric is arranged on the medical acrylic glue water layer, and the isolation paper covers the medical acrylic glue water layer and the 100-percent alginate non-woven fabric. Water absorption cotton used by the alginate adhesive bandage is formed by the non-woven fabric produced by 100-percent alginate. Compared with an ordinary adhesive bandage, the alginate adhesive bandage has the advantages that the self sterilization and biodegradation effects are realized, a liquid-state protection film is formed on the surface of a wound, and the wound adhesion can be avoided. Therefore the use of an anti-sticky film is not needed, and the alginate adhesive bandage belongs to a fire-new waterproof, heeling-promoting and self-sterilization alginate adhesive bandage capable of forming the protection film on the surface of the wound.

Description

Alginate bandage and manufacture method thereof
Technical field
The present invention relates to one and there is waterproof, Promotive union, from sterilizing, and form alginate bandage and the manufacture method thereof of protecting film in wound surface.
Background technology
Human living standard is more and more higher, and the requirement for medical treatment and nursing is also more and more higher, and the small-sized wound in life, preferred plan can oneself directly process exactly, and this has just expedited the emergence of the rise of bandage product.Existing bandage structure, as shown in Figure of description 1, adopts and does not substantially have coating hot-melt adhesive on fabric springy, glue arranges absorbent cotton, compound one deck Anti-adhering plastic film again on absorbent cotton.There is following problem in such structure: (1) viscosity is inadequate; Existing bandage, all adopt medical hot melt adhesive as the carrier of viscosity, and although medical hot melt adhesive production technology is fairly simple, because the viscosity of medical hot melt adhesive is innately unstable, and hold viscosity extreme difference, after being affixed on human body, if the motion of perspiration or slightly large fabric width, or when external friction, will directly come off, if when water breakthrough, directly viscosity can be lost.(2) fabric without water proofing property and lack elastic force; After wound is sticked, should avoid getting wet for preventing wound infection as far as possible, but existing bandage all can not reach effective waterproof, if and adopt the fabric of waterproof, PUR can be coated again because of on waterproof fabrics, due to the existence of waterproofing agent, the binding strength of PUR and fabric will be not enough, and face the technical barrier that glue comes off; Existing fabric elastic force is inadequate simultaneously, and general elastic force is below 20%, and during use, comfort level is inadequate, and foreign body sensation is strong, after coated position is bending, easily forms breach at edge, loses the defencive function of bandage.(3), after absorbent cotton and damaged Wound contact a period of time of cotton material, be easy to form adhesion with Wound exudate, just must must peel off and clean a wound, formation secondary damage.The method that existing bandage solves is on cotton absorbent cotton, add attached one deck Anti-adhering plastic film, can bring the problem of water absorption deficiency thus, cause Wound exudate not to be completely absorbed, affect the reparation of wound.In addition, this absorbent cotton only can make wound and air partition form limited protection to wound, and sometimes due to the existence of Anti-adhering plastic film, adsorptive pads and wound can not be completely closely sealed, and antibacterial is easily invaded, and can not promote wound healing.
Summary of the invention
First object of the present invention has waterproof, Promotive union, from sterilizing, and forms the alginate bandage of protecting film in wound surface.
The technical scheme realizing the present invention's first object is a kind of alginate bandage, is made up of waterproof fabrics, medical acrylic acid glue layer, 100% alginate non-woven fabrics and protection sheet; The Weftwise stretch of described waterproof fabrics is greater than 150%; Described medical acrylic acid glue layer coating is arranged at the side of waterproof fabrics; Described 100% alginate non-woven fabrics is arranged on medical acrylic acid glue layer; Described release paper covers on medical acrylic acid glue layer and 100% alginate non-woven fabrics.The thickness of described waterproof fabrics is no more than 300 grams/m, and through three grades of water-proofing treatment.Described medical acrylic acid glue layer is full coat layer or the discontented coating being provided with room.
Second object of the present invention is to provide a kind of waterproof, Promotive union, from sterilizing, and forms the manufacture method of the alginate bandage of protecting film in wound surface.
The technical scheme realizing the present invention's second object is a kind of manufacture method of alginate bandage, comprises the following steps:
Step one: prepare the stretch fabric that Weftwise stretch is greater than 150%, and through three grades of water-proofing treatment; Described Weftwise stretch cloth adopts cotton covering yarn or synthetic cotton covering yarn to obtain; Stretch fabric fabric thickness is no more than 300 grams/m, and the fabric tissue adopted is plain weave or twill-weave, or plain weave adds twill-weave;
Step 2: prepare the medical acrylic acid glue that curing degree is 40% ~ 60%;
Step 3: prepare the 100% alginate non-woven fabrics that grammes per square metre scope is 60 ~ 140 grams/m; Alginate non-woven fabrics to be purity be 100% alginate, obtained the fibre bundle of different length and rugosity by wet spinning, then obtain non-woven fabrics through the production of water acupuncture manipulation; According to the non-woven fabrics size that final products need, be cut into the suitable width of rolling, this width is less than point bandage substrate width cut in step 5; As preferably, then cut the nonwoven fabric roll to being less than finished product bandage width.
Step 4: be evenly coated in by medical acrylic acid glue on Weftwise stretch cloth, the fabric with glue after gluing enters drying tunnel, dries the solvent in glue through multistage drying tunnel; The THICKNESS CONTROL of medical acrylic acid glue is between 15 to 25; The temperature entirety of drying tunnel arranges from low to high, and temperature range is between 40 DEG C to 140 DEG C; Glue spreading method is direct gluing or transfer gluing; Bandage is more ventilative also can save glue simultaneously to make can to arrange room during gluing.
Step 5: scribble glue one side compound one deck release paper at fabric, receive and roll up greatly, longitudinally divide according to the requirement of final finished size and be cut to suitable width, obtain bandage base material;
Step 6: 100% alginate non-woven fabrics of step 3 and the bandage base material of step 5 are positioned over bandage and produce on machine, the antiseized protection sheet of bandage and packaging bag on frame simultaneously;
Step 7: the release paper peeling off glue one side on bandage base material; synchronously in the compound of center, slitting is the non-woven fabrics of fritter; again synchronous in the one side compound having glue and non-woven fabrics protection sheet, finally bond the packaging bag of bandage, obtain alginate bandage.
After have employed technique scheme, the present invention has following useful effect: (1) the present invention takes full advantage of the biological degradability of alginate, biocompatibility, the interactive grade good characteristic good with tissue liquid, what allow is direct in the face of wound, therefore, it is possible to ensure that wound heals in wet condition, can absorb the body fluid that wound oozes out completely, play the effect of sterilizing, and its anti ability can be avoided and wound adhesion simultaneously; After considering the laminating of bandage and human body, the practical situation that body surface curvature is different, have employed high latitude elasticity fabric, adapts to the requirement of different body surface simultaneously; Consider again simultaneously and can face various service condition in the actual use procedure of bandage Yu after being affixed on human body; the requirement of waterproof antiperspirant and viscosity is high; thus adopt medical acrylic acid as the mediator sticked; therefore be a kind of brand-new waterproof; Promotive union; from sterilizing, and form the alginate bandage of protecting film in wound surface.
(2) the present invention is by material innovation and process innovation perfect adaptation, and selection elastic force breakthrough on material reaches the weft spring cloth of 150%, and has done 3 grades of water-proofing treatment; Glue adopts viscosity stronger, not only realize the tack requirements after finished product, also the medical acrylic acid preventing the phenomenon of coming unstuck in process of production can be realized, in process of production compared with PUR, do not produce and come unstuck this mainly because medical acrylic acid is for liquid, can partly penetrate in fabric structure; And directly in the face of the part of wound, adopt biodegradable alginate non-woven fabrics, substitute original absorbent cotton, then take full advantage of every good characteristic of alginate.In technique, fabric directly does water-proofing treatment, do not adopt the face coat waterproof that part bandage product uses, thus ensure that the flexibility of fabric; Adopt drying road type glue spreading method, the binding strength of glue and fabric is higher, and at semi-finished product phase compound release paper, in the form of glue face, the full coat method of the existing bandage of incomplete employing, and adopt interval or decorative pattern to be coated with method selectively, the breathability that glue quantity can also increase finished product can not only be saved; Do not adopt the antiadhesion barrier that other bandage products must have, but directly allow alginate non-woven fabrics in the face of wound.By the combination of brand new technical and material and technology; give bandage brand-new function; comprise: waterproof is (containing anti-foreign liquid ability; meet water viscosity hold facility after finished product pastes), sterilizing, biodegradation, form liquid protective film in wound surface; never adhesion wound, adapts to human body surface curvature and complete closely sealed joint function.
(3) following effect can be reached when bandage of the present invention uses: after being affixed on human body surface, docile property is splendid, can be attached at human body surface completely; Directly reach three grades of water-proof functions, effectively can to block in daily life various liquid to the infringement of wound, after realizing pasting under water inlet or perspiration state, bandage does not fall and does not take off, and can use the effect of more than seven days continuously simultaneously; Alginate non-woven fabrics Absorbable rod reaches the liquid of deadweight 11 times, effectively can absorb the exudate of wound; Adhesion wound, during stripping, can not the related wound trauma that will have scabbed; Form protecting film and aerobic environment in wound surface, promote wound healing; The sterilization ability that alginate fibre is born, effectively can reduce the probability of superinfection.
Accompanying drawing explanation
In order to make content of the present invention more easily be clearly understood, below according to specific embodiment also by reference to the accompanying drawings, the present invention is further detailed explanation, wherein
Fig. 1 is bandage structural representation of the prior art, eliminates protection sheet in figure.
Fig. 2 is bandage structural representation of the present invention, eliminates protection sheet in figure.
Attached number in the figure is:
Waterproof fabrics 1, medical acrylic acid glue layer 2,100% alginate non-woven fabrics 3.
Detailed description of the invention
(embodiment 1)
See Fig. 2, the alginate bandage of the present embodiment, be made up of waterproof fabrics 1, medical acrylic acid glue layer 2,100% alginate non-woven fabrics 3 and protection sheet; The Weftwise stretch of waterproof fabrics 1 is greater than 150%; Medical acrylic acid glue layer 2 coating is arranged at the side of waterproof fabrics 1; 100% alginate non-woven fabrics 3 is arranged on medical acrylic acid glue layer 2; Release paper covers on medical acrylic acid glue layer 2 and 100% alginate non-woven fabrics 3.The thickness of waterproof fabrics 1 is no more than 300 grams/m, and through three grades of water-proofing treatment.Medical acrylic acid glue layer 2 is full coat layer or the discontented coating being provided with room.
Manufacture method, is characterized in that comprising the following steps:
Step one: prepare the stretch fabric that Weftwise stretch is greater than 150%, and through three grades of water-proofing treatment; Weftwise stretch cloth adopts cotton covering yarn or synthetic cotton covering yarn is obtained or other modes can; In order to there be better comfort level, stretch fabric fabric thickness is no more than 300 grams/m, and the fabric tissue adopted is plain weave or twill-weave, or plain weave adds twill-weave.
Step 2: prepare the medical acrylic acid glue that curing degree is 40% ~ 60%;
Step 3: preparing grammes per square metre scope is 60 ~ 140 gram/m of 100% alginate non-woven fabrics; According to the non-woven fabrics size that final products need, be cut into the suitable width of rolling, be cut to the nonwoven fabric roll of 2.3cm width in the present embodiment.Alginate extracts from Sargassum, is obtained the fibre bundle of different length and rugosity by wet spinning, then obtains non-woven fabrics through the production of water acupuncture manipulation.
Step 4: be evenly coated in by medical acrylic acid glue on Weftwise stretch cloth, the fabric with glue after gluing enters drying tunnel, dries the solvent in glue through multistage drying tunnel; The THICKNESS CONTROL of medical acrylic acid glue is between 15 to 25; The temperature entirety of drying tunnel arranges from low to high, and temperature range is between 40 DEG C to 140 DEG C; Glue spreading method is direct gluing or transfer gluing.
Step 5: scribble glue one side compound one deck release paper at fabric, receive and roll up greatly, longitudinally divide according to the requirement of final finished size and be cut to suitable width, be cut to the large volume of fabric of 8cm width in the present embodiment, obtain bandage base material;
Step 6: 100% alginate non-woven fabrics of step 3 and the bandage base material of step 5 are positioned over bandage and produce on machine, the antiseized protection sheet of bandage and packaging bag on frame simultaneously;
Step 7: the release paper peeling off glue one side on bandage base material; synchronously in the compound of center, slitting is the non-woven fabrics of fritter; again synchronous in the one side compound having glue and non-woven fabrics protection sheet, finally bond the packaging bag of bandage, obtain alginate bandage.
Above-described specific embodiment; object of the present invention, technical scheme and beneficial effect are further described; be understood that; the foregoing is only specific embodiments of the invention; be not limited to the present invention; within the spirit and principles in the present invention all, any amendment made, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. an alginate bandage, is characterized in that: be made up of waterproof fabrics (1), medical acrylic acid glue layer (2), 100% alginate non-woven fabrics (3) and protection sheet; The Weftwise stretch of described waterproof fabrics (1) is greater than 150%; Described medical acrylic acid glue layer (2) coating is arranged at the side of waterproof fabrics (1); Described 100% alginate non-woven fabrics (3) is arranged on medical acrylic acid glue layer (2); Described release paper covers on medical acrylic acid glue layer (2) and 100% alginate non-woven fabrics (3).
2. a kind of alginate bandage according to claim 1, is characterized in that: the thickness of described waterproof fabrics (1) is no more than 300 grams/m, and through three grades of water-proofing treatment.
3. a kind of alginate bandage according to claim 2, is characterized in that: described medical acrylic acid glue layer (2) is full coat layer or the discontented coating being provided with room.
4. a manufacture method for alginate bandage, is characterized in that comprising the following steps:
Step one: prepare the stretch fabric that Weftwise stretch is greater than 150%, and through three grades of water-proofing treatment;
Step 2: prepare medical acrylic acid glue;
Step 3: prepare 100% alginate non-woven fabrics; According to the non-woven fabrics size that final products need, be cut into the suitable width of rolling, this width is less than point bandage substrate width cut in step 5;
Step 4: be evenly coated in by medical acrylic acid glue on Weftwise stretch cloth, the fabric with glue after gluing enters drying tunnel, dries the solvent in glue through multistage drying tunnel;
Step 5: scribble glue one side compound one deck release paper at fabric, receive and roll up greatly, longitudinally divide according to the requirement of final finished size and be cut to suitable width, obtain bandage base material;
Step 6: 100% alginate non-woven fabrics of step 3 and the bandage base material of step 5 are positioned over bandage and produce on machine, the antiseized protection sheet of bandage and packaging bag on frame simultaneously;
Step 7: the release paper peeling off glue one side on bandage base material; synchronously in the compound of center, slitting is the non-woven fabrics of fritter; again synchronous in the one side compound having glue and non-woven fabrics protection sheet, finally bond the packaging bag of bandage, obtain alginate bandage.
5. the manufacture method of alginate bandage according to claim 4, is characterized in that: in described step one, and described Weftwise stretch cloth adopts cotton covering yarn or synthetic cotton covering yarn to obtain; Stretch fabric fabric thickness is no more than 300 grams/m, and the fabric tissue adopted is plain weave or twill-weave, or plain weave adds twill-weave.
6. the manufacture method of alginate bandage according to claim 5, is characterized in that: the curing degree of the medical acrylic acid glue in described step 2 is 40% ~ 60%.
7. the manufacture method of alginate bandage according to claim 6, is characterized in that: in described step 3, the grammes per square metre scope of 100% alginate non-woven fabrics is 60 ~ 140 grams/m, cuts the width to being less than finished product bandage, and becomes web-like.
8. the manufacture method of alginate bandage according to claim 7, is characterized in that: in described step 4, the THICKNESS CONTROL of medical acrylate glue water is between 15 to 25; The temperature entirety of drying tunnel arranges from low to high, and temperature range is between 40 DEG C to 140 DEG C; Glue spreading method is direct gluing or transfer gluing.
9. according to the manufacture method of the alginate bandage one of claim 1 to 8 Suo Shu, it is characterized in that: the alginate non-woven fabrics in described step 3 to be purity be 100% alginate, obtained the fibre bundle of different length and rugosity by wet spinning, then obtain non-woven fabrics through the production of water acupuncture manipulation.
10. the manufacture method of alginate bandage according to claim 8, is characterized in that: in described step 4 during gluing, sets different gluing shapes and room according to demand.
CN201410447318.4A 2014-09-03 2014-09-03 Alginate bandage and its manufacturing method Active CN104224446B (en)

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105662713A (en) * 2015-12-29 2016-06-15 无锡恒成医疗科技股份有限公司 Medical dressing for treating large area wound and manufacturing method thereof
CN110916900A (en) * 2018-09-20 2020-03-27 常州华联保健敷料有限公司 Hydrogel medical dressing and preparation method thereof
CN110960722A (en) * 2019-12-14 2020-04-07 广东泰宝医疗科技股份有限公司 Antibacterial alginate bandage and preparation method thereof
CN112545755A (en) * 2019-12-06 2021-03-26 苏州恒星医用材料有限公司 Manufacturing method of wear-resistant fabric breathable adhesive bandage
CN112546287A (en) * 2019-12-11 2021-03-26 苏州恒星医用材料有限公司 Antibacterial adhesive bandage and manufacturing method thereof
CN112545754A (en) * 2019-12-06 2021-03-26 苏州恒星医用材料有限公司 Method for manufacturing silica gel adhesive bandage
CN112914831A (en) * 2019-12-06 2021-06-08 苏州恒星医用材料有限公司 Manufacturing method of thermochromic adhesive bandage

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CN101433484A (en) * 2007-11-13 2009-05-20 青岛喜盈门集团有限公司 Seaweed fiber medical dressing
CN102600019A (en) * 2012-03-09 2012-07-25 烟台万利医用品有限公司 Medical hydrogel dressing and preparation method thereof
CN103169570A (en) * 2013-03-06 2013-06-26 苏州艾美医疗用品有限公司 Hemostasis bandaid and preparation method thereof
CN103768650A (en) * 2014-01-26 2014-05-07 深圳市博立生物材料有限公司 Wound regenerating and repairing bandage and manufacture method thereof

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CN202136485U (en) * 2011-06-20 2012-02-08 青岛海诺生物工程有限公司 Elastic waterproof adhesive bandage

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Publication number Priority date Publication date Assignee Title
CN101433484A (en) * 2007-11-13 2009-05-20 青岛喜盈门集团有限公司 Seaweed fiber medical dressing
CN102600019A (en) * 2012-03-09 2012-07-25 烟台万利医用品有限公司 Medical hydrogel dressing and preparation method thereof
CN103169570A (en) * 2013-03-06 2013-06-26 苏州艾美医疗用品有限公司 Hemostasis bandaid and preparation method thereof
CN103768650A (en) * 2014-01-26 2014-05-07 深圳市博立生物材料有限公司 Wound regenerating and repairing bandage and manufacture method thereof

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105662713A (en) * 2015-12-29 2016-06-15 无锡恒成医疗科技股份有限公司 Medical dressing for treating large area wound and manufacturing method thereof
CN110916900A (en) * 2018-09-20 2020-03-27 常州华联保健敷料有限公司 Hydrogel medical dressing and preparation method thereof
CN112545755A (en) * 2019-12-06 2021-03-26 苏州恒星医用材料有限公司 Manufacturing method of wear-resistant fabric breathable adhesive bandage
CN112545754A (en) * 2019-12-06 2021-03-26 苏州恒星医用材料有限公司 Method for manufacturing silica gel adhesive bandage
CN112914831A (en) * 2019-12-06 2021-06-08 苏州恒星医用材料有限公司 Manufacturing method of thermochromic adhesive bandage
CN112546287A (en) * 2019-12-11 2021-03-26 苏州恒星医用材料有限公司 Antibacterial adhesive bandage and manufacturing method thereof
CN110960722A (en) * 2019-12-14 2020-04-07 广东泰宝医疗科技股份有限公司 Antibacterial alginate bandage and preparation method thereof

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