CN104208447A - Pharmaceutical composition for treating stroke - Google Patents
Pharmaceutical composition for treating stroke Download PDFInfo
- Publication number
- CN104208447A CN104208447A CN201410489576.9A CN201410489576A CN104208447A CN 104208447 A CN104208447 A CN 104208447A CN 201410489576 A CN201410489576 A CN 201410489576A CN 104208447 A CN104208447 A CN 104208447A
- Authority
- CN
- China
- Prior art keywords
- parts
- pharmaceutical composition
- apoplexy
- blood
- treating stroke
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention discloses a pharmaceutical composition for treating stroke. By weight, the pharmaceutical composition is composed of the following active ingredients: 12-24 parts of Angelica dahurica, 12-24 parts of Ligusticum wallichii, 12-24 parts of Asarum sieboldii, 12-24 parts of cimicifugae foetidae, 12-24 parts of gastrodia elata, 12-24 parts of fleece-flower roots, 12-24 parts of Uncaria tomentosa, 12-24 parts of scorpio, 12-24 parts of lumbricus, 9-21 parts of Salvia miltiorrhiza, 9-21 parts of radix sileris, 9-21 parts of Angelica sinensis, 9-21 parts of Carthamus tinctorius, 9-21 parts of Panax notoginseng, 9-21 parts of borneol, 9-21 parts of saponin, 9-21 parts of fructus cannabis, 9-21 parts of chastetree fruit, 9-21 parts of white mustard seeds and 9-21 parts of lycopodium clavatum. The pharmaceutical composition for treating stroke can overcome shortcomings of the existing medicine for treating stroke and is good in the curative effect.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of pharmaceutical composition for the treatment of apoplexy.
Background technology
In life, apoplexy is in the stage occurred frequently at present, and apoplexy is one of current large major causes of death of old people three (apoplexy, heart disease and cancer).Apoplexy can be divided into cerebral infarction and the large class of hemorrhagic apoplexy two.Change along with life style and mode of operation, apoplexy has more become a kind of disease of high incidence, apoplexy is the brain local blood circulation obstacle that cerebrovascular disease causes acute or subacute disease, with soldier, so faint, syncope, speech is obscure, a kind of pathological changes that hemiplegia etc. are main manifestations.Be more common in old people, especially hypertension or obviously arteriosclerosis person.Often feel a buzz, dizzy, face mouth numb, murky drowsiness, personality is unusual, irritability, finger separately active, arm is numb, pain etc., these all belong to the main manifestations sign of apoplexy.If have arteriosclerosis, diabetes, coronary heart disease, high fat of blood, blood high viscosity syndrome, obesity, cervical spondylosis, excessive sexual behaviour etc., all can cause apoplexy.
The understanding origin of traditional Chinese medicine syndrome caused by wind pathogen for a long time.In < <, through > >, there is not the name of " apoplexy ", but there are the names of disease such as " sudden falling down ", " emotional syncope ", " scorching syncope ", " coma ", " hemiplegia ", " hemiplegia ", " pruritus due to wind pathogen ", " disorder of head ", as < < Plain Questions regulating menstruation opinion > > day: " blood with gas; and walk; be coma; faint and die of a sudden illness; gas is returned raw, does not return dead "." apoplexy " name of disease is first appeared in the < < gold doctor outline > > of Han dynasty Zhang Zhongjing: " husband's wind be disease; hemiplegia, or but the unsuccessful person of arm, this is numbness; faint and rapid pulse, apoplexy makes so ".After the Chinese, although there are many discussions about apoplexy later age, in the development of name of disease, do not vary widely, be mainly to discuss from refinement and the differentiation of apoplexy name.The traditional Chinese medical science also has clear and definite judgement to this sick etiology and pathogenesis: in < <, through > >, clearly propose positive QI-insufficiency, battalion defends weakness, in exopathogen people, causes apoplexy.As < < Ling Shu Miraculous Pivot or Divine Axis.The evil piece of writing of Ci Jiezhen > > cloud: " visitor is in body half partially for exogenous pathogen, and its people is dark, and Nei Juying defends, and battalion defends slightly and declines, and vital qi goes, and pathogen remaining alone is sent out as hemiplegia "; Han dynasty Zhang Zhongjing thinks that apoplexy is due to collaterals being void and defenceless, and ailment said due to cold or exposure is taken advantage of a weak point in opponent's defence in people, due to harmful climatic factors does not rush down; Sui Dynasty Chao Yuanfang (550-630 A.D.) is pointed out weakness of the spleen and stomach, and insufficiency of vital energy and blood is the basic reason of apoplexy.Ming Dynasty's Zhang Jingyue is advocated " non-wind ", the saying of " internal injury long-pending damage ", and as the unconcerned non-wind > > cloud of the assorted card of < < Jing Yue's complete work, " non-wind one card, the so-called apoplexy card of instant people is also.This demonstrate,proves common apoplectic stroke, and apoplectic stroke is many by doting, this all internal injury long-pending damage declining and right, due to former non-affection of exogenous wind-cold." pioneering " hyperactive liver-YANG causing syndrome of liver-wind " theory of Qing Dynasty's leaf sky scholar; as < < Linzheng Zhinan Yi apoplexy > > day: " class person's puppet is also, since modern age, doctor, regardless of the modern Ye Shi invention of true and false endogenous wind, is the change of yang-energy in body.Liver is that wind is dirty, controlling nocturnal emission with astringent drugs blood attenuation, and the kidney failing to nourish the liver, the liver losing its adequate flourishment, therefore liver-yang is partially high, rises during endogenous wind." Wang Qingren in < < correction of the errors of medical works hemiplegia origin > >, propose " hemiplegia, loss vigour, be its origin.”
Modern medicine is called cerebrovascular disease by apoplexy, refer to the disordered brain function that various angiogenic cerebral lesions cause, and drawn the achievement in research of medical image, neuroscience, it is mainly due to entocranial artery tube wall generation pathological changes, cause lumen of vessels narrow, vessel wall elasticity reduces.The outer embolus of cranium enters entocranial artery with blood and causes arteries inaccessible, and local brain tissue hypoxic-ischemic, congestion and edema, degeneration necrosis, cause a series of Clinical changes.Doctor trained in Western medicine mainly adopts by expanding blood vessel, reducing blood viscosity, blood fat reducing at present, strengthen the blood supply of hypoxic-ischemic cerebral tissue and the method treatments such as neuronal function recovery of the interior survival of promotion " half blanking bar ", can not effect a radical cure completely, have obvious medication side effect, and medical expense is expensive.Yet the prevention of traditional Chinese medicine wind and treatment have, method is many, effective, the distinguishing feature originally of curing the disease, and no matter in the generation that reduces untoward reaction, or aspect animal economy adjusting, all has the incomparable advantage of doctor trained in Western medicine.
At present, treatment apoplexy does not have specific medicine at present, and Chinese medicine and western medicine has.The medicine of western medicine cerebrovascular disease has advantages of rapid-action, with strong points, but Western medicine is often devoted to eliminate local disease, model of action is single, be difficult to accomplish that some Chinese medicines can treat from blood and blood vessel the object of cerebral thrombosis simultaneously, and Western medicine has, and Drug resistance is large and side effect is large, in using the process of these chemicals medicines, to other organs of user, can bring very large infringement, and after drug withdrawal in the short time state of an illness shortcoming such as will recur.The medicine for the treatment of apoplexy is more, and long-lasting, the safety of Chinese medicine, the comprehensive aspect for the treatment of are all that Western medicine can not be than.For example China Patent Publication No. is CN103223121A, a kind of apoplectic hemiplegia ball is disclosed, a kind of apoplectic hemiplegia for the treatment of, select: eupolyphoge sinensis, Scorpio, Lumbricus, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Radix Aconiti Lateralis Preparata, Hylarana guentheri, Rhizoma Arisaematis, the Rhizoma Pinelliae, Flos Carthami, Agkistrodon, Scolopendra, Rhizoma Acori Graminei, Concha Haliotidis form, above-mentioned each taste medicine is pressed to prescription part by weight and drop into, pulverize smalls (120 order), by medicine pill manufacture method, make honeyed pill, the heavy 9g of every ball, but there is the problem that dosage form is single.Current effective less for the treatment of by Chinese herbs apoplexy, part Chinese medicine price is higher.
Summary of the invention
The technical problem to be solved in the present invention is the deficiency that overcomes existing treatment apoplexy medicine, and a kind of good pharmaceutical composition of apoplexy effect for the treatment of is provided.
In pharmaceutical composition of the present invention, the consumption of each component is that inventor draws through a large amount of practice summaries, by the raw material of following weight parts, is made:
Preferably, it is to be made by weight by following raw materials according:
More preferably, it is to be made by weight by following raw materials according:
The dosage form of pharmaceutical composition of the present invention can be the medically acceptable dosage forms such as capsule, pill, tablet, decoction, and their preparation method, supplementary product consumption are undertaken by existing common process.
The present invention also comprises the application of aforementioned pharmaceutical compositions in the medicine of preparation treatment apoplexy.
The traditional Chinese medical science thinks, apoplexy many by positive QI-insufficiency, deficient qi and blood, stagnation of QI blood addiction, phlegm-damp the moon is stagnant, endogenous wind is recklessly acted, hold expectorant under the arm holds addiction upper punch, arteries and veins Lip river, spleen resistance, brain Lip river under the arm and lose and support etc. and fall ill.This disease of Chinese traditional treatment can dredging the meridian, regulates QI and blood, promotes rehabilitation.
In pharmaceutical composition prescription of the present invention:
The Radix Angelicae Dahuricae--there is detumescence, evacuation of pus, pain relieving, relaxing muscles and tendons, active effect;
Herba Asari--there is dispersing cold for relieving pain, sensible effects on neural system;
Rhizoma Gastrodiae--there is apoplexy sequela, numb hand and foot, half of unsuccessful effect;
Scorpio--there is endogenous wind stopping relieving convulsion, removing obstruction in the collateral to relieve pain, eliminating stagnation effect;
Radix Saposhnikoviae--there is only contraction, analgesic effect;
Ramulus Uncariae Cum Uncis--there is dredge the meridian passage, the meridians effect of having one's ideas straightened out;
Semen Sinapis Albae--there is resolving mass and removing the obstruction of the collateral pain relieving, the circulation of qi promoting effect of reducing phlegm;
Radix Angelicae Sinensis--the effect of invigorating blood circulation of enriching blood;
Flos Carthami--there is promoting blood circulation to remove obstruction in the collateral, the logical bolt of blood stasis dispelling, the slow-witted effect of apoplexy wood;
Borneolum Syntheticum--there is the brain of having one's ideas straightened out nervus centralis, impatency effect;
Fructus Cannabis--there is loosening bowel to relieve constipation, the digestive function effect of having one's ideas straightened out;
Rhizoma Chuanxiong--there is promoting flow of QI and blood, removing obstruction in the collateral to relieve pain effect;
Rhizoma Cimicifugae--there is yang invigorating, getter, also unit, only headache effect;
The Radix Polygoni Multiflori--there is relieving convulsion headache, the effect of stimulating the menstrual flow of relievining asthma;
Pheretima--there is suppressing the hyperactive liver to relieve the wind syndrome, promoting blood circulation to remove obstruction in the collateral effect;
Fructus Viticis--there is loose wind heat, the nerve of having one's ideas straightened out, the flat wind effect of heat clearing away;
Radix Salviae Miltiorrhizae--there is blood-activating and qi-promoting, the effect of the apoplexy of having one's ideas straightened out network joint;
Herba Lycopodii--there is soothing the channels and quicking the network vessels, switching function;
Radix Notoginseng--there is dissipating blood stasis, change bolt removing heat from blood, analgesic effect;
Fructus Gleditsia--there is sensible switching, the effect of blood stasis-eliminating and stagnation-dissipating endogenous wind stopping.
The pure Chinese medicine composition of pharmaceutical composition of the present invention, there is treatment wind syndrome of head pain, premonitory apoplexy, to human brain central nervous system can play blood circulation promoting and blood stasis dispelling, dissolve thrombus obstruction, vessel softening, dredging are obstructed nervus centralis, repair nerve impulse path, the nerve that is obstructed of having one's ideas straightened out, can recover the neural circulation of normal human, promote blood to relax logical, strengthen brain cell active, make brain immunologic function healthy, help digest system and blood system normal circulation function.The old people uncomfortable to brothers, cerebral infarction is dull-witted, the patient of apoplexy sequela shape have treatment migraine, the effect of wind syndrome of head pain disease.
The specific embodiment
With specific embodiment, the invention will be further described below, but the present invention is not limited to these embodiment.
Embodiment 1
By proportional quantity, take above each raw material, decoct with water twice, add for the first time 7 times of water gagings, decoct 1.5 hours, add for the second time 8 times of water gagings, decoct collecting decoction 1.5 hours, filter, filtrate is concentrated into relative density be 1.30 extractum of (70 ℃ time survey), adds the dextrin adjuvant of conventional amount used, routinely technique, make capsule, 0.5g/ grain.
Embodiment 2
By proportional quantity, take above each raw material, decoct with water twice, add for the first time 7 times of water gagings, decoct 1.5 hours, add for the second time 8 times of water gagings, decoct 1.5 hours, collecting decoction, filters, and filtrate is concentrated into relative density be 1.30 extractum of (70 ℃ time survey), add appropriate cane sugar powder, routinely the agent of technique granulation.
Embodiment 3
Take above each raw material, decoct with water twice, add for the first time 8 times of water gagings, decoct 2 hours, add for the second time 6 times of water gagings, decoct 1.5 hours, collecting decoction, filters, and obtains decoction.
Embodiment 4
By proportional quantity, take above each raw material, decoct with water twice, add for the first time 7 times of water gagings, decoct 1.5 hours, add for the second time 8 times of water gagings, decoct 1.5 hours, collecting decoction, filters, filtrate is concentrated into relative density be 1.30 extractum of (70 ℃ time survey), the magnesium stearate adjuvant that adds conventional amount used, technique is made tablet routinely, specification 0.5g/ sheet.
Embodiment 5
Take above each raw material, clean and dry, co-grinding is crossed 80 mesh sieves, adds making pellets by mixing medical powder with honey, obtains pill.
Experimental example: the embodiment of the present invention 5 treatment apoplexy clinical observation on the therapeutic effect:
Chinese medicine composition clinical trial statistics of the present invention is as follows:
1, case and method
2008-2013, connects and controls patient's 78 examples, male's 54 examples, women's 24 examples, 44 years old mean age.All cases is all that cerebrovascular disease clinical manifestation is that diagnostic criteria is determined by apoplectic hemiplegia, premonitory apoplexy.The embodiment of the present invention 5, honeyed pill, every day 3 times, each 1 ball, oral; 15d is 1 course for the treatment of, after drug withdrawal 1-3d, can carry out next course for the treatment of, is used in conjunction 3 courses for the treatment of.
2, efficacy determination
According to clinical symptom disappearance, be as the criterion, be divided into recovery from illness, effective, effective, invalid.
Recovery from illness: lamprophonia, action is white as, life is autonomous, can do labor in general.
Effective: language is substantially clear, action substantially freely, can be lived on one's own life substantially.
Effective: language is substantially clear, but slightly inconvenience of action.
Invalid: brain swoon wish servant, hemianesthesia, hemiplegia, aphasis.
3, curative effect is summed up
| Number of cases | Recovery from illness | Effective | Effectively | Invalid | Effective percentage |
| 78 | 37 | 24 | 14 | 3 | 96.2％ |
Claims (4)
1. a pharmaceutical composition for the treatment of apoplexy, is characterized in that: this pharmaceutical composition is to be made by the raw material of following weight parts:
2. the pharmaceutical composition for the treatment of apoplexy according to claim 1, is characterized in that: this pharmaceutical composition is to be made by the raw material of following weight parts:
3. the pharmaceutical composition for the treatment of apoplexy according to claim 1, is characterized in that: this pharmaceutical composition is to be made by the raw material of following weight parts:
4. the application of the pharmaceutical composition described in any one in the medicine of preparation treatment apoplexy in claim 1-3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410489576.9A CN104208447A (en) | 2014-09-23 | 2014-09-23 | Pharmaceutical composition for treating stroke |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410489576.9A CN104208447A (en) | 2014-09-23 | 2014-09-23 | Pharmaceutical composition for treating stroke |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104208447A true CN104208447A (en) | 2014-12-17 |
Family
ID=52090620
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410489576.9A Pending CN104208447A (en) | 2014-09-23 | 2014-09-23 | Pharmaceutical composition for treating stroke |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104208447A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105079455A (en) * | 2015-08-24 | 2015-11-25 | 济南高天机械设备有限公司 | Medicament for treating cerebral infarction and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103816398A (en) * | 2014-01-13 | 2014-05-28 | 李绍华 | Medicine composition for treating stroke and cerebral thrombosis |
-
2014
- 2014-09-23 CN CN201410489576.9A patent/CN104208447A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103816398A (en) * | 2014-01-13 | 2014-05-28 | 李绍华 | Medicine composition for treating stroke and cerebral thrombosis |
Non-Patent Citations (1)
| Title |
|---|
| 朱仕兵等: "中医药治疗缺血性中风的进展", 《辽宁中医学院学报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105079455A (en) * | 2015-08-24 | 2015-11-25 | 济南高天机械设备有限公司 | Medicament for treating cerebral infarction and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103071128B (en) | Externally-applied plaster for curing dysmenorrhea | |
| CN103393840A (en) | Traditional Chinese medicine composition for treating osteoarthritis | |
| CN104667244A (en) | Foot bath composition for treating primary dysmenorrheal | |
| CN101919988B (en) | Medicine compound for curing rheumatism rheumatoid arthritis and preparation method thereof | |
| CN104398982A (en) | Traditional Chinese medicine composition for treating traumatic injury and joint pain and swelling | |
| CN100998656A (en) | Medicated wine for tonifying bone and removing obstruction in channels | |
| CN103816476A (en) | Medicine composition for treating injury and paralysis of oculomotor nerve and preparation method and application thereof | |
| CN105963457A (en) | Traditional Chinese medicine foot soaking composition capable of promoting rehabilitation of neck and shoulder pain and lumbocrural pain | |
| CN102698214B (en) | Traditional Chinese medicine for treating migraine and preparation method thereof | |
| CN102225118B (en) | Blood-activating wind-dispelling liquid | |
| CN103705632A (en) | Application of mammary aggregation dispersing tablets in preparation of medicines for treating penis hardening disease | |
| CN104208447A (en) | Pharmaceutical composition for treating stroke | |
| CN105381289A (en) | Pharmaceutical composition for treating abnormal menstruation | |
| CN101502597B (en) | Medicament for treating stomachache and preparation method thereof | |
| CN101129718B (en) | Traditional Chinese medicine preparation for treating leuoderma | |
| CN101269191B (en) | Externally applied medicament for treating hepatopathy | |
| CN103816398A (en) | Medicine composition for treating stroke and cerebral thrombosis | |
| CN1060076C (en) | Gucixiao pill for removing spur | |
| CN110841007B (en) | Traditional Chinese medicine composition for treating cerebral apoplexy sequela and application thereof | |
| CN103494887A (en) | Chinese medicine composition for treating knee arthritis and preparation method thereof | |
| CN102698149B (en) | Traditional Chinese medicine for treating chronic headache and preparation method thereof | |
| CN101214298B (en) | Externally-applied pharmaceutical composition for treating mazopathy | |
| CN102335304B (en) | Chinese medicine composition for dispelling wind, removing dampness, invigorating blood circulation, and relieving pain and preparation method thereof | |
| CN105106786A (en) | Traditional Chinese medicine composition capable of dredging collaterals and relaxing muscles as well as preparation and production method of composition | |
| CN104623333A (en) | Drug for treating facial paralysis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20141217 |
|
| WD01 | Invention patent application deemed withdrawn after publication |