CN104208115A - Traditional Chinese medicine composition prepared from dried sandalwood and ixeris sonchifolia - Google Patents
Traditional Chinese medicine composition prepared from dried sandalwood and ixeris sonchifolia Download PDFInfo
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Abstract
A traditional Chinese medicine composition prepared from dried sandalwood and ixeris sonchifolia. The invention belongs to the field of traditional Chinese medicines and relates to a traditional Chinese medicine composition for treating hypertension. The traditional Chinese medicine composition is prepared from following raw materials comprising, by weight, 1-10 parts of the dried sandalwood, 1-10 parts of the ixeris sonchifolia, 1-10 parts of calendula officinalis, 1-10 parts of roots of melastoma sanguineum, and 1-10 parts of cucubalus roots. The traditional Chinese medicine composition can be prepared into tablets, pills, hard capsules and granules through conventional pharmaceutical methods in traditional Chinese pharmacy.
Description
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technical field:
The invention belongs to the field of Chinese medicines, relate to one and treat hypertensive Chinese medicine composition, be specifically related to a kind of by being the Chinese medicine composition that raw material is made for dry Lignum Santali Albi, Herba Ixeritis Denticulatae, Calendula officinalis, Radix Melastomatis Sanguinei root, Radix Cucubali.
technical background:
Hypertension (hypertensive disease) a kind ofly continues to raise as the chronic disease of main manifestations with arteriotony, often causes the pathological changes of the vitals such as the heart, brain, kidney and occur corresponding consequence.
The blood pressure standard used according to the World Health Organization's suggestion is: all adult normal's systolic pressures should be less than or equal to 140mmHg(18.6kPa), diastolic pressure is less than or equal to 90mmHg(12kPa).That is systolic pressure is at 141 ~ 159mmHg(18.9 ~ 21.2kPa) between, diastolic pressure is at 91 ~ 94mmHg(12.1 ~ 12.5kPa) between, be borderline hypertension.During office hypertension, must repetitive measurement blood pressure, have the meansigma methods of double diastolic pressure at least at 90mmHg(12.0kPa) or more just can be diagnosed as hypertension.Only a blood pressure rising person still can not make a definite diagnosis, but needs follow-up observation.
Hypertension is modal cardiovascular diseases, is the great public health problem in global range.Chinese residents nutrition and the Health Situation survey result of 2004 show, and China 18 years old and above prevalence of hypertension rate are 18.8%, estimate that national number of patients is more than 1.6 hundred million.Compared with 1991, prevalence rises 31%, number of patients increase about more than 7,000 ten thousand people.
1998, China's cerebrovascular occupied the second of urbanite's cause of death, ranks first in rural area.The annual death in the whole nation is more than 1,000,000, and the patient about 5,000,000 ~ 6,000,000 of survival, wherein more than 75% leaves deformity in various degree, causes white elephant to individual, family and society.And the Major Risk Factors of apoplexy is hypertension.Meanwhile, blood pressure raises or the fuse cord of various diseases, and the onset risk of the diseases such as coronary heart disease, heart failure and kidney disease can be made to increase.Because part hyperpietic there is no obvious clinical symptoms, hypertension is otherwise known as " the invisible killer " of human health.Therefore improve the understanding to hypertension, have extremely important meaning to early prevention, in time treatment.
According to the difference that blood pressure raises, hypertension is divided into 3 grades: 1 grade of hypertension (slightly) systolic pressure 140 ~ 159mmHg; Diastolic pressure 90 ~ 99mmHg.2 grades of hypertension (moderate) systolic pressure 160 ~ 179mmHg; Diastolic pressure 100 ~ 109mmHg.3 grades of hypertension (severe) systolic pressure >=180mmHg; Diastolic pressure >=110mmHg.Isolated systolic hypertension systolic pressure >=140mmHg; Diastolic pressure <90mmHg.
Pathogenesis:
1, be accustomed to factor heredity: approximately half hyperpietic has family history, ignore to add to seasonal variations and answer season clothing.
2, environmental factors: scientific research shows, lacks the important mechanisms that anion is also hypertension incidence in environment.Negative aeroion enters lung through respiratory tract, enters blood circulation by film exchange system, arrives whole body each histoorgan with blood circulation, directly to stimulate, neural reflex and act on each system of body by body fluid mode, produces good physiological effect.After anion enters blood, discharge electric charge, although very little, very sensitive for the blood electric charge under poised state.It directly can affect composition and the distribution situation of charged particle in blood (protein, hemocyte), makes abnormal blood form and physicochemical characteristics normalization; And by promoting the oxidation-reduction process of body tissue, particularly by strengthening the oxidizing process of the vital tissues such as liver, brain, kidney, activate multiple enzyme system, adjustment and optimisation effect is played to the fat of body, protein, carbohydrate, water and electrolyte metabolism.Therefore, lacking anion in air is also the important reason of of causing hypertension to produce.
3, other: (1) body weight: overweight people's sickness rate is high.(2) contraceptive.(3) Sleep Apnea-hypopnea Syndrome.(4) age: sickness rate the trend increased with age growth, and person's sickness rate was high in more than 40 years old.
Hypertension formation basic theory is sketched:
First, we first abandon any pathologic and complication factor, we are from physics's angle hypertension, according to hydromechanical principle and compression power principle, I likens into the pressure circulation system of sealing heart and blood vessel and blood capillary, in other words human body is a machine, and heart and blood vessel are exactly lubricating system.Propose in refined auspicious Chinese medicine encyclopedia, the traditional Chinese medical science thinks that hypertension formation basic theory is: unstable, the sympathetic and chaotic rising causing blood pressure of parasympathetic nervous system of vascular endothelial tissue metabolism.
1, talk about from modal overweight people's hypertension, too fat hyperliposis, causes certain extruding to blood vessel, after pipeline is extruded, power source needs to strengthen power just may make original circulation reach circulation, and power source power strengthens, pipeline pressure also can strengthen thereupon, just defines high pressure.
2, the thrombosis that internal blood and other diseases cause causes, the metabolism of blood, discharges thorough not, forms dirt, cause certain blocking, pressure can be made to raise to pipeline at pipe interior.
3, senile pipeline sclerosis and disease sclerosis, pipeline gives a discount and hardens, and can cause high pressure.
4, disease blood capillary blocking and the blocking of traumatic blood capillary, be also one of factor wherein.
5, body disease causes, a part of hyperglycemic patients, is because digestive system is too excited, in the intestines and stomach, has pathological changes, will form certain blood circulation blocking, also can cause high pressure in the intestines and stomach body.
6, the congenital and posteriori disappearance of heart aspect.
7, cerebrovascular disease causes.
8, blood dries up the high pressure caused.
Vulnerable crowd:
Repeatedly prove following crowd through scientific experiments and easily suffer from hypertension:
1, the family members such as father and mother, brother, sister person that has hypertension history;
2, overweight people; Acidic physique (in body, anion concentration is not enough) person.
3, undue picked-up salinity person;
4, excessive drinking person.
This disease symptoms:
Headache: position is many at hindbrain, and with symptoms such as Nausea and vomiting.If often feel headache, and very violent, and feeling sick again simultaneously and feel sick, may be just the signal transformed to malignant hypertension.
Dizzy: female patient occurs more, may feel to some extent when squatting down suddenly or stand up.
Tinnitus: ears tinnitus, the persistent period is longer.
Shortness of breath and palpitation: hypertension can cause myocardial hypertrophy, cardiac dilatation, myocardial infarction, cardiac insufficiency.These are all the symptoms causing shortness of breath and palpitation.
Insomnia: mostly be difficulty falling asleep, early awakening, sleep not steady and sure, easily have horrible nightmares, easily wake up with a start.This lacks of proper care relevant with cerebral cortex dysfunction and autonomic nervous function.
Numb limbs and tense tendons: common finger, toe numbness or skin, as the sense of ant row, are pointed dumb.Also may there is numbness in other positions of health, also may paraesthesia, even hemiplegia.
The invention provides one and treat hypertensive Chinese medicine composition, evident in efficacy.
summary of the invention:
The object of this invention is to provide one and treat hypertensive Chinese medicine composition.
Another object of the present invention is to provide the preparation method of this Chinese medicine composition.
This Chinese medicine composition that also provides of the present invention treats the application in essential hypertension and angina drug in preparation.
The object of the invention is to realize in the following manner:
One treats hypertensive Chinese medicine composition, is to be made up of the raw material of following weight portion: dry Lignum Santali Albi 1 ~ 10, Herba Ixeritis Denticulatae 1 ~ 10, Calendula officinalis 1 ~ 10, Radix Melastomatis Sanguinei root 1 ~ 10, Radix Cucubali 1 ~ 10.
This Chinese medicine composition is preferably made up of the raw material of following weight portion: dry Lignum Santali Albi 10, Herba Ixeritis Denticulatae 8, Calendula officinalis 6, Radix Melastomatis Sanguinei root 4, Radix Cucubali 2.
This Chinese medicine composition is preferably made up of the raw material of following weight portion: dry Lignum Santali Albi 2, Herba Ixeritis Denticulatae 4, Calendula officinalis 6, Radix Melastomatis Sanguinei root 8, Radix Cucubali 10.
This Chinese medicine composition is preferably made up of the raw material of following weight portion: dry Lignum Santali Albi 10, Herba Ixeritis Denticulatae 10, Calendula officinalis 5, Radix Melastomatis Sanguinei root 5, Radix Cucubali 1.
This Chinese medicine composition is preferably made up of the raw material of following weight portion: dry Lignum Santali Albi 8, Herba Ixeritis Denticulatae 6, Calendula officinalis 6, Radix Melastomatis Sanguinei root 8, Radix Cucubali 8.
Chinese medicine composition of the present invention adopts pharmaceutical methods conventional in Chinese materia medica to be prepared into tablet, pill, hard capsule, granule.
Chinese medicine composition of the present invention can be prepared as follows: get the crude drug in Chinese medicine composition prescription, be ground into fine powder, sieve, and mixing, to obtain final product.
Chinese medicine composition of the present invention also can be adopted and prepare with the following method: get the crude drug in Chinese medicine composition prescription, decoct with water 1 ~ 3 time, each 1 ~ 3 hour, collecting decoction, filter, filtrate reduced in volume thick paste extremely, dry, pulverize, sieve, add adjuvant, mixing, to obtain final product.
Preferably adopt and prepare with the following method: get the crude drug in Chinese medicine composition prescription of the present invention, decoct with water 2 times, the 1st time 3 hours, 2nd time 2 hours, collecting decoction, filtered, filtrate reduced in volume thick paste extremely, dry, pulverize, sieve, add appropriate amount of starch, mixing, makes granule, drying, tabletting and get final product.
Chinese medicine composition of the present invention is used in the medicine of preparation treatment essential hypertension.
Chinese medicine composition of the present invention is also used in the anginal medicine of preparation treatment.
Technique effect of the present invention is verified by following experimentation:
experiment one:the clinical research of traditional Chinese medicine composition for treating essential hypertension of the present invention
1 clinical data
1.1 physical data
Two groups of totally 30 examples, adopt random digits table be divided into treatment group 15 example and matched group 15 routine.In treatment group 15 example, man 7 example, female 8 example; 42 ~ 59 years old age, average (48.5 ± 8.5) year; The course of disease 1.5 ~ 10 years, average (8.5 ± 1.6) year; Hypertension stage: I phase 4 example, II phase 10 example, III phase 1 example.In matched group 15 example, man 8 example, female 7 example; 40 ~ 58 years old age, average (49.9 ± 7.3) year; The course of disease 1.4 ~ 11 years, average (8.4 ± 1.5) year; Hypertension stage: I phase 4 example, II phase 9 example, III phase 2 example.The aspects such as two groups of sexes, age, the course of disease, Hypertension stages compare, and P>0.05, has comparability.
1.2 diagnostic criteria
With reference to the international uniform standard of the international hypertension alliance of WHO in 1999 formulation, systolic pressure (SBP) >18.7 kPa, diastolic pressure (DBP) >12 kPa, both have the person of meeting at least.The unified standard that Hypertension stage is worked out according to " clinical disease diagnosis is according to curing improvement standard ": be divided into I phase, II phase, III phase.
1.3 dialectical foundations
Revise with reference to " tcm clinical practice disease Standardization of diagnosis and curative effect ".Primary symptom: headache, dizzy, tremble, being irritable and getting angry easily, insomnia, dry mouth with bitter taste, red tongue with yellow fur or micro-greasy, wiry and frequent pulse.Secondary disease: knowledge is become deaf, limb numb, flushing, constipation, red, forgetful, muscular twitching of urinating.All possess first 6 of primary symptom, in secondary disease any 3, adds typical tongue, pulse condition person, can dialectical be high liver fire, hold concurrently and press from both sides the essential hypertension of the turbid pattern of syndrome of expectorant.
1.4 exclusion standard
(1) acute or Chronic Liver renal function injury person; (2) concurrent severe cardiac disease of brain patient, as heart failure (heart failure), apoplexy etc.; (3) temporary blood pressure rising person; (4) non-high liver fire, the turbid card person of double folder expectorant.
2 methods
2.1 Therapeutic Method
Treatment group: oral Chinese medicine composition of the present invention (Chinese medicine composition of the embodiment of the present invention 1), specification: the heavy 0.3g of every sheet, oral, one time 5,2 times on the one.Matched group: oral mountain chrysanthemum hypertension pill (Hengli Group Pharmaceutical Co., Ltd., Hebei), specification: the heavy 0.3g of every sheet, oral, one time 5,2 times on the one.Two groups was all 1 course for the treatment of with 4 weeks, can take for 1 ~ 2 course for the treatment of continuously, add up curative effect after 3 months according to the state of an illness.
2.2 points for attention
Treatments period is stopped using without exception the Chinese medicine of impact on hypertension and immunologic function; The excitatory foods such as diet wine cheese, pungent, delicious food; The quiet god of the heart pleases, and is emotionally stable.
2.3 observation of curative effect
2.3.1 observation index and method
(1) clinical symptoms, sign: headache, dizzy, tremble, being irritable and getting angry easily, insomnia, dry mouth with bitter taste, red tongue with yellow fur or micro-greasy, the change of the aspects such as wiry and frequent pulse;
(2) observational technique: treatments period the 2nd weekend and at the end of measuring blood pressure (seat peace and quiet have a rest 10 min), follow up a case by regular visits to measuring blood pressure 3 times at every turn, average, Simultaneously test heart rate, and record simultaneous phenomenon and untoward reaction;
(3) before taking medicine, 1d takes the photograph sheet and looks into optical fundus, electrocardiogram.
Every one-phase is taken medicine and was checked blood, routine urinalysis the same day, extracts limosis vein blood and surveys blood fat, blood glucose, uric acid, hemorheology, Liver and kidney function and electrolyte.Treatment in 4 weeks terminates all indexs of rear check.
2.3.2 efficacy evaluation essential hypertension tcm syndrome criterion of therapeutical effect according to cardinal symptom as headache, dizzy, tremble, being irritable and getting angry easily, insomnia, the symptom such as dry mouth with bitter taste light and heavy degree difference point light (+), in (++), heavy (+++), serious (++++) 4 grades of score.To minor symptom as knowledge become deaf, limb is numb, flushing, constipation, red, forgetful etc. aobviously hiddenly to score of urinating, point obviously (++), indistinctly (+), score without (-).Count 1 point, transference cure meter 0 point for 1+number, in Table 1-1, statistics integration equals 4 grades of score, adds with or without score, shows hidden scoring.
Table 1-1 primary symptom light and heavy degree score-sheet
2.3.3 efficacy assessment standard
Effective: diastolic pressure decline >1.3 kPa(10 mmHg), and reach normal range.Though diastolic pressure is not down to normally, declined 2.7 kPa(20mmHg) more than, integration reduces 70% ~ 90% before comparatively treating.
Effective: diastolic pressure decline <1.3 kPa, but reach normal range.Diastolic pressure comparatively treats front 1.3 ~ 2.5 kPa that decline, but does not reach normal range.Systolic pressure declines and comparatively treats front >4.0 kPa, and integration reduces 36% ~ 69% before comparatively treating.
Invalid: do not reach above effective standard, integration only reduces by less than 35% person before comparatively treating.
2.3.4 statistical method measurement data is used
± s represents, compares and cross-reference t checks, enumeration data application χ between group
2inspection.
3 results
3.1 therapeutic outcome
In Table 1-2.Treatment group is obviously better than matched group, and through statistical procedures, two groups of total effective rate comparing differences have significance (P<0.05).
Table 1-2 two groups of therapeutic outcome comparative examples (%)
| Group | Number of cases | Effective | Effectively | Invalid | Effectively total |
| Treatment group | 15 | 12（80.0） | 2（13.3） | 1（6.7） | 14（93.3） |
| Matched group | 15 | 6（40.0） | 5（33.3） | 4（26.7） | 11（73.3） |
3.2 liang of group cardinal symptoms improve situation
In Table 1-3.Table 1-3 show 6 kinds of cardinal symptoms (headache, dizzy, tremble, being irritable and getting angry easily, insomnia, dry mouth with bitter taste etc.) all have clear improvement, its remission rate treatment group is obviously better than matched group (P<0.01).
Table 1-3 two groups of cardinal symptoms improve situation
Note: compare * P<0.01 with matched group
3.3 liang of group blood pressure situations compare
In Table 1-4.After two groups of treatments, blood pressure significantly declines, and with this group before treatment, difference has significance (#P<0.01 or * P<0.05), compares with after treatment of control group, and difference has significance (△ P<0.05).
Table 1-4 two groups treatment front and back blood pressure situation compares (
± s)
Note: * P<0.05, #P<0.01 with this group before treatment; △ P<0.05 is compared with after treatment of control group
Before and after 3.4 liang of group treatments, Blood Lipid situation compares
In Table 1-5.After treatment, two groups of blood fat obviously decline, and difference has significance (#P<0.01 or * P<0.05) with this group before treatment; More also significant difference (△ P<0.05) is had after two groups of treatments.
Table 1-5 two groups treatment front and back Blood Lipid situation compares (
± s) mmolL
-1
Note: * P<0.05, #P<0.01 with this group before treatment; △ P<0.05 is compared with after treatment of control group
Before and after 3.5 liang of group treatments, hemorheology situation compares in Table 1-6.After treatment, two groups of hemorheological property are all improved, and with this group before treatment, difference has significance (#P<0.01 or * P<0.05); Compare after two groups of treatments, difference has significance (△ P<0.05)
Table 1-6 two groups treatment front and back hemorheology implementations compares (
± s)
Note: * P<0.05, #P<0.01 with this group before treatment; △ P<0.05 is compared with after treatment of control group
BUA(blood uric acid before and after 3.6 liang of group treatments) horizontal situation of change
In Table 1-7.After two groups of treatments, BUA level all has decline, and with this group before treatment, difference has significance (#P<0.01 or * P<0.05); Compare after two groups of treatments, difference has significance (△ P<0.05).
The horizontal situation of change of table 1-7 two groups treatment front and back BUA compares (
± s) pmolL
-1
Note: * P<0.05, #P<0.01 with this group before treatment; △ P<0.05 is compared with after treatment of control group
3.7 untoward reaction are observed
Two groups take medicine 4 weeks after, conventional to blood, urine, feces, blood electrolyte, Liver and kidney function inspection is showed no exception.The only dizzy pain for the treatment of group 1 example, 1 example is felt sick; The dizzy pain of matched group 3 example, 2 examples are felt sick, and 2 routine cardiopalmus (needn't drug withdrawal, can disappear gradually), have no other obvious adverse reaction.
4 conclusions: Chinese medicine composition of the present invention has good effect in treatment essential hypertension, and is better than control drug mountain chrysanthemum hypertension pill.Research also shows: Chinese medicine composition of the present invention has obvious reducing effect to spontaneous hypertensive rat blood pressure, angiotensinⅡ, aldosterone and inner cortex hormone; Can coronary flow be increased, dilating coronary blood vessel, improve blood supply of cardiac muscle oxygen supply; Peripheral blood vessel can be expanded, peripheral vascular resistance is declined, adjust the compliance of myocardial vascular, adjustment and improvement result are played to cardiovascular system, normal to maintain blood pressure.
experiment two: Chinese medicine composition of the present invention is on the impact of spontaneous hypertensive rat blood pressure
1 experiment material
1.1 laboratory animal
Bull spontaneous hypertensive rat (SHR) 40, body weight 225 ± 30g.Wistar rat 10, male and female dual-purpose, 12 weeks ages of Mus, body weight 245g ~ 310g.
1.2 experimental drug
The Chinese medicine composition of the embodiment of the present invention 2, is adjusted to every ml and is equivalent to raw medicinal herbs 1g by concentration.In the conversion of body surface area ratio, the conversion factor of rat is 0.018, and the volume gastric infusion of 1ml/100g pressed by above-mentioned medicinal liquid.
Positive Chinese medicine: mountain chrysanthemum hypertension pill, Hengli Group Pharmaceutical Co., Ltd., Hebei produces, and Chinese medicine being made into concentration is 0.0288g/ml.By the volume gastric infusion of 1ml/100g.
1.3 experimental apparatus
Conscious Rat blood pressure heart rate analyzer, HX-III type
2 experimental techniques
2.1 grouping
Laboratory animal is divided into 5 groups, often organizes 10, grouping situation is as follows:
(1) blank group, Wistar rat;
(2) model control group, SHR model comparison;
(3) positive controls, takes mountain chrysanthemum hypertension pill;
(4) Chinese medicine composition group of the present invention, takes the Chinese medicine composition of the embodiment of the present invention 2;
(5) Chinese medicine composition of the present invention removes dry Lignum Santali Albi group, takes Chinese medicine composition Chinese medicine composition of the present invention being removed dry Lignum Santali Albi, with reference to the method preparation of description embodiment 2.
2.2 administration
Before formal experiment, pressure measurement every day trains 1 time, continuous 7 days, conform until rat, SHR be divided into 5 groups at random after blood pressure stabilization, often organize 10, namely blank group, SHR model control group, mountain chrysanthemum hypertension pill positive controls, Chinese medicine composition group of the present invention, Chinese medicine composition of the present invention remove dry Lignum Santali Albi group, gastric infusion respectively, mountain chrysanthemum hypertension pill positive controls, Chinese medicine composition group of the present invention, Chinese medicine composition of the present invention remove dry Lignum Santali Albi group administration 2.5ml/d, blank group, model control group gives the distilled water of same volume.Administration time is every morning.Successive administration 28 days, the blood pressure after measuring administration in the 29th day.
2.3 experimental procedure
Before pressure measurement, SHR is put into 37 ± 1 DEG C of electrothermostats, heat and Mus arteria caudalis is fully expanded, the systolic pressure of rat tail artery is indirectly surveyed with Conscious Rat blood pressure heart rate analyzer, get continuous 3 pressure values and be no more than the meansigma methods of 5mmHg difference as answering measuring blood pressure value, to adopt before and after self and between group, statistical disposition is carried out in F inspection, to compare before and after administration and the significance of blood pressure mean difference between group.
3 experimental results
In Table 2-1 and table 2-2.
SBP(mmHg is surveyed) after the table 2-1 administration course for the treatment of
| Group | Before administration | After medicine 28 days | The range of decrease |
| Blank group | 157.35±10.13 | 156.41±9.71* | 0.94±0.23? |
| Model control group | 243.35±12.63 | 233.12±19.66 | 10.23±3.86? |
| Positive controls | 225.67±10.26? | 163.45±16.44△ | 62.22±16.54△ |
| Chinese medicine composition group of the present invention | 235.66±19.45? | 165.64±16.11△ | 70.02±15.56△* |
| Chinese medicine composition of the present invention removes dry Lignum Santali Albi group | 243.87±9.23? | 198.61±12.37△ | 45.26±19.24△ |
Note: with model control group than △ P < 0.05, with positive controls than * P < 0.05
DBP(mmHg is surveyed) after the table 2-2 administration course for the treatment of
| Group | Before administration | After medicine 28 days | The range of decrease |
| Blank group | 71.35±9.65 | 70.64±5.35 | ?0.89±0.33? |
| Model control group | 140.73±11.72? | 137.24±4.42? | 3.49±0.59? |
| Positive controls | 137.26±14.17 | 92.22±7.73△ | ?45.04±15.82△ |
| Chinese medicine composition group of the present invention | 137.55±10.38 | 83.65±5.24△ | 53.90±14.34△*# |
| Chinese medicine composition of the present invention removes dry Lignum Santali Albi group | 137.56±17.87 | 91.65±4.56△ | ?45.91±16.76△ |
Note: compare △ P < 0.05 with model control group, with positive controls than * P < 0.05, removes dry Lignum Santali Albi group with Chinese medicine composition of the present invention and compares # P < 0.05.
From table 2-1,2-2, model group rats is at experimental session blood pressure no significant difference (P > 0.05) compared with before treatment.Gavage Chinese medicine composition group blood pressure of the present invention continuously slowly to decline, after 28 days SBP, DBP respectively mean decrease be 70.02 ± 15.56mmHg, 53.90 ± 14.34mmHg, notable difference (△ P < 0.05 ﹚ is had compared with model group, also (* P < 0.05 ﹚, also has notable difference (* P < 0.05 ﹚ compared with positive controls notable difference compared with removing dry Lignum Santali Albi group with Chinese medicine composition of the present invention; Give mountain chrysanthemum hypertension pill blood pressure also obviously to decline, after 28 days SBP, DBP respectively mean decrease be 62.22 ± 16.54mmHg, 45.04 ± 15.82mmHg, be obviously better than model group (△ P < 0.05).
Above result shows, Chinese medicine composition of the present invention has obvious antihypertensive effect, and its hypotensive effect is comparatively lasting, and is obviously better than the Chinese medicine composition that Chinese medicine composition of the present invention removes dry Lignum Santali Albi, is also obviously better than positive control drug mountain chrysanthemum hypertension pill.
detailed description of the invention:
embodiment 1: tablet
Prescription: dry Lignum Santali Albi 80g, Herba Ixeritis Denticulatae 60g, Calendula officinalis 60g, Radix Melastomatis Sanguinei root 80g, Radix Cucubali 80g.
Method for making: get the crude drug in prescription, decocts with water 2 times, the 1st time 3 hours, the 2nd time 2 hours, collecting decoction, filters, filtrate reduced in volume thick paste extremely, dry, pulverize, sieve, add appropriate amount of starch, mixing, make granule, dry, be pressed into 1000, coating, obtain final product.
Usage and consumption: oral, one time 4 ~ 6,2 ~ 3 times on the one.
embodiment 2: tablet
Prescription: dry Lignum Santali Albi 80g, Herba Ixeritis Denticulatae 60g, Calendula officinalis 60g, Radix Melastomatis Sanguinei root 80g, Radix Cucubali 80g.
Method for making: get the crude drug in prescription, be ground into fine powder, sieve, adds appropriate dextrin, and mixing, tabletting, makes 1000.
Usage and consumption: oral, one time 4 ~ 6,2 ~ 3 times on the one.
embodiment 3: pill
Prescription: dry Lignum Santali Albi 20 g, Herba Ixeritis Denticulatae 40 g, Calendula officinalis 60 g, Radix Melastomatis Sanguinei root 80 g, Radix Cucubali 100 g.
Method for making: get the crude drug in prescription, be ground into fine powder, sieve, mixing, adds Mel, general ball, makes 5000 balls.
Usage and dosage: oral, 20 ~ 40 balls, every day 2 ~ 3 times.
embodiment 4: capsule
Prescription: dry Lignum Santali Albi 100 g, Herba Ixeritis Denticulatae 100 g, Calendula officinalis 50 g, Radix Melastomatis Sanguinei root 50 g, Radix Cucubali 10 g.
Method for making: get the crude drug in prescription, decocts with water 2 times, each 2 hours, collecting decoction, and filter, filtrate reduced in volume thick paste extremely, dry, pulverize, sieve, and adds appropriate dextrin, and mixing, makes granule, incapsulate, make 1000, to obtain final product.
Usage and consumption: oral, one time 4 ~ 6,2 ~ 3 times on the one.
embodiment 5: tablet
Prescription: dry Lignum Santali Albi 80g, Herba Ixeritis Denticulatae 60g, Calendula officinalis 60g, Radix Melastomatis Sanguinei root 80g, Radix Cucubali 80g.
Method for making: get the crude drug in prescription, decocts with water 3 times, each 1 hour, collecting decoction, and filter, filtrate reduced in volume thick paste extremely, dry, pulverize, sieve, add appropriate amount of starch, and mixing, makes granule, dry, is pressed into 1000, coating, obtains final product.
Usage and consumption: oral, one time 4 ~ 6,2 ~ 3 times on the one.
embodiment 6: granule
Prescription: dry Lignum Santali Albi 100 g, Herba Ixeritis Denticulatae 80 g, Calendula officinalis 60 g, Radix Melastomatis Sanguinei root 40 g, Radix Cucubali 20 g.
Method for making: get the crude drug in prescription, decocts with water 1 time, 3 hours, and decocting liquid filters, and filtrate reduced in volume thick paste extremely, dry, pulverize, sieve, and adds appropriate lactose, and mixing, dry, pulverize, add appropriate syrup, and granulate, granulate makes granule 10000g.
Usage and dosage: oral, a 20 ~ 40g, every day 2 ~ 3 times.
Claims (10)
1. treat a hypertensive Chinese medicine composition, it is characterized in that, this Chinese medicine composition is made up of the raw material of following weight portion: dry Lignum Santali Albi 1 ~ 10, Herba Ixeritis Denticulatae 1 ~ 10, Calendula officinalis 1 ~ 10, Radix Melastomatis Sanguinei root 1 ~ 10, Radix Cucubali 1 ~ 10.
2. Chinese medicine composition as claimed in claim 1, it is characterized in that, this Chinese medicine composition is made up of the raw material of following weight portion: dry Lignum Santali Albi 10, Herba Ixeritis Denticulatae 8, Calendula officinalis 6, Radix Melastomatis Sanguinei root 4, Radix Cucubali 2.
3. Chinese medicine composition as claimed in claim 1, it is characterized in that, this Chinese medicine composition is made up of the raw material of following weight portion: dry Lignum Santali Albi 2, Herba Ixeritis Denticulatae 4, Calendula officinalis 6, Radix Melastomatis Sanguinei root 8, Radix Cucubali 10.
4. Chinese medicine composition as claimed in claim 1, it is characterized in that, this Chinese medicine composition is made up of the raw material of following weight portion: dry Lignum Santali Albi 10, Herba Ixeritis Denticulatae 10, Calendula officinalis 5, Radix Melastomatis Sanguinei root 5, Radix Cucubali 1.
5. Chinese medicine composition as claimed in claim 1, it is characterized in that, this Chinese medicine composition is made up of the raw material of following weight portion: dry Lignum Santali Albi 8, Herba Ixeritis Denticulatae 6, Calendula officinalis 6, Radix Melastomatis Sanguinei root 8, Radix Cucubali 8.
6. Chinese medicine composition as claimed in any one of claims 1 to 5, wherein, is characterized in that, this Chinese medicine composition adopts pharmaceutical methods conventional in Chinese materia medica to be prepared into tablet, pill, hard capsule, granule.
7. Chinese medicine composition as claimed in claim 6, is characterized in that, this Chinese medicine composition is adopted and prepared with the following method: get the crude drug in Chinese medicine composition prescription, be ground into fine powder, sieve, and mixing, to obtain final product.
8. Chinese medicine composition as claimed in claim 6, is characterized in that, this Chinese medicine composition is adopted and prepared with the following method: get the crude drug in Chinese medicine composition prescription, decoct with water 1 ~ 3 time, each 1 ~ 3 hour, collecting decoction, filter, filtrate reduced in volume thick paste extremely, dry, pulverize, sieve, add adjuvant, mixing, to obtain final product.
9. Chinese medicine composition as claimed in any one of claims 1 to 5, wherein, is characterized in that, the application of this Chinese medicine composition in preparation treatment essential hypertension medicine.
10. Chinese medicine composition as claimed in any one of claims 1 to 5, wherein, it is characterized in that, this Chinese medicine composition is preparing the application in antianginal drug.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410371919.1A CN104208115A (en) | 2014-07-31 | 2014-07-31 | Traditional Chinese medicine composition prepared from dried sandalwood and ixeris sonchifolia |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410371919.1A CN104208115A (en) | 2014-07-31 | 2014-07-31 | Traditional Chinese medicine composition prepared from dried sandalwood and ixeris sonchifolia |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105012410A (en) * | 2015-08-08 | 2015-11-04 | 王恒信 | Nursing assisting medicine capsule made of polygonum cynanchoides hemsl and used for treating hypertension and preparing method |
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|---|---|---|---|---|
| CN1186681A (en) * | 1997-01-02 | 1998-07-08 | 陆新华 | Blood stasis removing and recovery agent and its use |
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2014
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1186681A (en) * | 1997-01-02 | 1998-07-08 | 陆新华 | Blood stasis removing and recovery agent and its use |
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| 张晓磊: "清热解毒法在原发性高血压病治疗中的应用", 《吉林中医药》 * |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105012410A (en) * | 2015-08-08 | 2015-11-04 | 王恒信 | Nursing assisting medicine capsule made of polygonum cynanchoides hemsl and used for treating hypertension and preparing method |
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