CN104208081A - Preparation for treating oral mucositis caused by paraquat - Google Patents
Preparation for treating oral mucositis caused by paraquat Download PDFInfo
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- CN104208081A CN104208081A CN201410373133.3A CN201410373133A CN104208081A CN 104208081 A CN104208081 A CN 104208081A CN 201410373133 A CN201410373133 A CN 201410373133A CN 104208081 A CN104208081 A CN 104208081A
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- oral mucositis
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- paraquat
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Abstract
A preparation for treating oral mucositis caused by paraquat. The preparation particularly includes following components: 250ml of a 0.9% sodium chloride solution, 0.16g of 2% lidocaine, 0.005g of dexamethasone and 0.08g of gentamicin. The preparation can reduce oral mucositis damage of a paraquat poisoning patient, can alleviating pain, can resist infection and can inhibit immunity. The preparation is used in a manner of mouth wash. A patient uses the preparation in the mouth-washing manner per 2 hours in daytime so that stimulation during local drug delivery is avoided and pain is alleviated. By means of frequent mouth washing, oral cavity can be moistened and large residue blocks and necrotic tissues can be removed. The preparation can reduce secretion and dental plaque, promotes a self-cleaning function of the oral cavity. A mouth washing liquid is low in cost and has an important clinical application value.
Description
Technical field
The invention belongs to oral disease therapeutic field, especially relate to one and treat the withered caused oral mucositis preparation of Pennisetum centrasiaticum Tzvel.
Background technology
N,N'-dimethyl-.gamma..gamma.'-dipyridylium has another name called Aerial gramoxone, Gramoxone, chemistry by name 1,1-dimethyl 4,4-bipyridine cation salt, exists with cationic form, and its poisoning and therapy mechanism is still in the exploratory stage, be the agricultural organic heterocyclic class contact herbicide that a kind of toxicity is very strong, have very strong toxic action to people, animal.In recent years along with the extensive use of N,N'-dimethyl-.gamma..gamma.'-dipyridylium, the patient of paraquat poisoning gets more and more, great majority due to wrongly take or commit suiside oral cause poisoning, N,N'-dimethyl-.gamma..gamma.'-dipyridylium has corrosivity, after oral ingestion, the oral cavity of patient, tongue, bottleneck throat, esophagus and gastric mucosa all can cause ulcer, oozing of blood, pain, surface forms one deck pod membrane, very easily infects.Patients with paraquat poisoning mortality rate high and patient's sanity, emotion extremely unstable.Canker sore pain unbearably, oral mucosa adhesion, patient dare not dehisce feed, treatment is lost the confidence, mismatches treatment.
Up to the present, for chemotherapy stomatitis prevention method mainly: rinsing the mouth 0.8% allopurinol solution (compound method is Allopurinol Tablets 2 grams of grind into powder+normal saline 250 ml); Rinsing the mouth method is 3 times/d, 20 ml/ time, rinsing the mouth 3 ~ 5 min, and the rinsing the mouth time is three after cold boiled water is gargled after the meal, to end of chemotherapy from chemotherapy.The weak point of the method is: total effective rate is on the low side, probably maintains about 60%.
Application number is 00136007.8, publication number is the Chinese patent literature of 1312068, name is called a kind of preventing decayed tooth antiinflammatory oral preparations, form prescription by fluoride, chlorhexidine hydrochloride, soda, bismuth subcarbonate, Main Function is the pathogenic bacterium killing and suppress to exist in oral cavity, eliminates oral mucosa inflammation, oral environment is made to be partial to alkalescence, in and oral cavity in acidulants, effectively preventing is carried out to dental caries and anaphylaxis, makes collutory, chewing gum dosage form.But do not mention and have which kind of effect to the withered caused oral mucositis of Pennisetum centrasiaticum Tzvel, the clinical trial result of preparation also needs to be investigated.
Application number is 200610012661.1, Authorization Notice No. is the Chinese patent literature of CN 101066298 B, name is called a kind of powder of Chinese traditional medicine for the treatment of oral mucositis, be made up of important source material etc. such as calamitas urinae hominis, Indigo Naturalis, catechu, Borneolum Syntheticums, but be only applicable to diameter at the common aphtha of 1 ~ 3 millimeter, inapplicable to the withered caused oral mucositis of Pennisetum centrasiaticum Tzvel.
Summary of the invention
In order to overcome the deficiency in background technology, the invention discloses one and treating the withered caused oral mucositis preparation of Pennisetum centrasiaticum Tzvel.
In order to realize described goal of the invention, the present invention adopts following technical scheme:
One treats the withered caused oral mucositis preparation of Pennisetum centrasiaticum Tzvel, and its concrete composition is: 0.9% 1 part, sodium chloride is 250ml, and 2% lignocaine 1 part is 0.16g, and dexamethasone 1 part is 0.005g, and gentamycin 1 part is 0.08g.
Treat a using method for the withered caused oral mucositis preparation of Pennisetum centrasiaticum Tzvel, get 0.9% sodium chloride respectively, 2% lignocaine, dexamethasone, celebrating is large, each portion, and mixing and stirring is the withered caused oral mucositis preparation of Pennisetum centrasiaticum Tzvel, and patient's rinsing the mouth on every 2 hours of daytime once.
Owing to have employed technique scheme, the present invention has following beneficial effect:
Sodium chloride meets physiological concentration, non-stimulated, and lignocaine is local anesthetic, eases the pain quickly and effectively, alleviates patient suffering, thus promotes appetite, has additional nutrients, and ensures the balance of nutrition, wound healing, strengthens patient's resistance.Gentamycin hinders the synthesis of bacterioprotein, thus reaches anti-infective object.Dexamethasone has the effect suppressing infection, Immunosuppression.This mixture formula more effectively alleviates the oral injury of patients with paraquat poisoning, facilitates the treatment of inflammatory reaction.Be applied to oral mucositis patient, have effect of pain relieving, infection.Studies have found that dexamethasone gargarism can obviously alleviate oral mucosa lesion caused by paraquat poisoning, and more early better.But dexamethasone gargarism composition is single, has limitation.Adopt dexamethasone and the compatible use of 2% lignocaine, add the curative effect of superposition use separately, this medical instrument has the oral mucosa lesion alleviating patients with paraquat poisoning, eases the pain, the effect of infection, Immunosuppression.Mode selects rinsing the mouth administration, allows every 2 h rinsing the mouth 1 time on patient's daytime, avoids stimulation during topical, palliates the agonizing sufferings, frequently gargle and oral cavity can be made moistening, removes bulk residue and slough, secretions reduces, reduce dental plaque, promote the self-cleaning action in oral cavity.This collutory is cheap, has important Clinical practice to be worth.
Detailed description of the invention
By explanation the present invention that the following examples can be detailed, disclose object of the present invention and be intended to protect all technological improvements in the scope of the invention.
Select 1 part, 0.9% sodium chloride to be 250ml, 2% lignocaine 1 part is 0.16g, and dexamethasone 1 part is 0.005g, and gentamycin 1 part is 0.08g.Get 0.9% sodium chloride respectively, 2% lignocaine, dexamethasone, celebrating is large, each portion, and mixing and stirring is the withered caused oral mucositis preparation of Pennisetum centrasiaticum Tzvel, and patient's rinsing the mouth on every 2 hours of daytime once.
My institute of clinical data accepts N,N'-dimethyl-.gamma..gamma.'-dipyridylium patient totally 68 examples for 2010 to 2013 for medical treatment, wherein man 31 routine female 37 example, age 16-27 year.Consultation time is at oral or 3-48 hour after sucking.Wherein 7 examples are large because of oral dose, produce the slight side effect such as vomiting, dizziness.26 examples are sucked the patient that do not swallow and are cured in 2 weeks and leave hospital, and 35 examples 10 days are cured afterwards or taken a turn for the better or be that final result is left hospital with multiple organ.
Observation index and judge index: the assessment of oral mucosa degree: evaluate with reference to WHO oral mucositis evaluation criterion: 0 degree: asymptomatic; 1 degree: bitterly, red and swollen; 2 degree: rubescent, fester; Energy consuming solid foods; 3 degree: fester, can only take food and stay matter; 4 degree: fester, can not take food.Cure deliberated index: oral mucosa redness goes down, pain disappears, and ulcer disappears, and mucosa is complete is healing.
Part not in the detailed description of the invention is prior art.
Claims (2)
1. treat the withered caused oral mucositis preparation of Pennisetum centrasiaticum Tzvel, it is characterized in that: its concrete composition is: 0.9% 1 part, sodium chloride is 250ml, and 2% lignocaine 1 part is 0.16g, and dexamethasone 1 part is 0.005g, and gentamycin 1 part is 0.08g.
2. treat the using method of the withered caused oral mucositis preparation of Pennisetum centrasiaticum Tzvel as claimed in claim 1 for one kind, it is characterized in that: get 0.9% sodium chloride respectively, 2% lignocaine, dexamethasone, celebrating is large, each portion, mixing and stirring is the withered caused oral mucositis preparation of Pennisetum centrasiaticum Tzvel, and patient's rinsing the mouth on every 2 hours of daytime once.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410373133.3A CN104208081A (en) | 2014-08-01 | 2014-08-01 | Preparation for treating oral mucositis caused by paraquat |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410373133.3A CN104208081A (en) | 2014-08-01 | 2014-08-01 | Preparation for treating oral mucositis caused by paraquat |
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| CN104208081A true CN104208081A (en) | 2014-12-17 |
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| CN201410373133.3A Pending CN104208081A (en) | 2014-08-01 | 2014-08-01 | Preparation for treating oral mucositis caused by paraquat |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108272854A (en) * | 2018-04-09 | 2018-07-13 | 青岛金丽雅医疗新技术发展有限公司 | A kind of drug and preparation method thereof for preventing chemotherapy induced stomatitis disease |
-
2014
- 2014-08-01 CN CN201410373133.3A patent/CN104208081A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 陈绍娟等: "含漱利多卡因、庆大霉素、地塞米松混合液", 《中国实用护理杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108272854A (en) * | 2018-04-09 | 2018-07-13 | 青岛金丽雅医疗新技术发展有限公司 | A kind of drug and preparation method thereof for preventing chemotherapy induced stomatitis disease |
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20141217 |
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| RJ01 | Rejection of invention patent application after publication |