CN104198336A - Method for detecting kinetic viscosity of ethylcellulose aqueous dispersion - Google Patents
Method for detecting kinetic viscosity of ethylcellulose aqueous dispersion Download PDFInfo
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- CN104198336A CN104198336A CN201410455590.7A CN201410455590A CN104198336A CN 104198336 A CN104198336 A CN 104198336A CN 201410455590 A CN201410455590 A CN 201410455590A CN 104198336 A CN104198336 A CN 104198336A
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- viscosity
- kinetic viscosity
- aquacoat
- aqueous dispersion
- mixed solvent
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention relates to a method for detecting the kinetic viscosity of an ethylcellulose aqueous dispersion, belonging to the technical field of pharmaceutical production. The method is easy to operate and can be used for rapidly detecting the kinetic viscosity of the ethylcellulose aqueous dispersion.
Description
Technical field
The invention belongs to pharmaceutical production technical field, relate to a kind of method for detection of Aquacoat kinetic viscosity.
Background technology
In the current widespread use of Aquacoat and oral and external preparation, oral formulations is mainly as the hydrophobic coatings material of tablet and particle.In external preparation, select suitable solvent, can be as thickening agent in ointment, washing or gel.Ping Shi viscosimeter estimated viscosity for regulation in " Chinese Pharmacopoeia " (2010 editions), complicated operation, the inspection side time at least needs 10 hours, and detection time is long.The pharmacopeia of comparing prescriptive procedure, this detection method is simple and efficient to handle, and experimental result is accurately stable.
Summary of the invention
In order to solve problems of the prior art, the invention provides a kind of method that detects Aquacoat kinetic viscosity, simple to operate, can fast detecting ethyl cellulose kinetic viscosity.
In order to realize object of the present invention, the technical scheme of employing is summarized as follows:
Detect a method for Aquacoat kinetic viscosity, concrete method is:
Take dry sample 1-~ 10g, add 30 ~ 200g mixed solvent, cover stopper, stir sample is dissolved completely, under 25 ± 0.1 DEG C of water bath with thermostatic control conditions, use No. 0 rotor to measure with rotational viscometer;
Result treatment: viscosity=rotor coefficient × rotating speed, the mean value of getting twice test is end product.
A kind of described method that detects Aquacoat kinetic viscosity, it is characterized in that, described mixed solvent is the conventional organic solvent in this area, is specially one or several potpourris in methyl alcohol, ethanol, ethyl acetate, cyclohexane, benzene, toluene.
Compared with prior art, the good effect that the present invention has is: can accurately simply measure ethyl cellulose kinetic viscosity, and easy and simple to handle, fast, record result accurately stable.
Embodiment
Below in conjunction with embodiment, the present invention is described further.
Example 1
1. accurately weigh through the 100-105 DEG C of sample 5g (being accurate to 0.01g) of dry 2 hours, put into 125ml white wide-mouth port grinding bottle, add the mixed solvent that 95.00g is suitable, cover stopper (mixed solvent: ethanol---toluene (1:4) solution quality ratio)
2. on magnetic stirring apparatus, stir, know that sample dissolves completely, bottle is put into constant temperature waters and keep 25 ± 0.1 DEG C, by NDJ-1 type rotational viscometer mensuration (using No. 0 rotor)
3. result treatment: viscosity=rotor coefficient × rotating speed
4. parallel experiment phase tolerace is no more than 5% of result, and the mean value that goes twice test is end product.
" represent that viscosity is more than or equal to 10mpa.s person, viscosity should be the 90.0%-110.0% that indicates viscosity to regulation in Chinese Pharmacopoeia; Mark viscosity is 6-10mpa.s person, and viscosity should be the 80.0%-120.0% of mark viscosity; Mark viscosity is less than or equal to 6mpa.s person, and viscosity should be the 75%-140% of mark viscosity.
Example 2
In test, choose ethyl cellulose N7, N10, tri-kinds of specifications of N20, intend comparing with reference to detection method and this method of Chinese Pharmacopoeia
Assay contrast
?exemplary scenario described here is only the explanation to the principle of the invention, and preferred embodiment of the present invention, should be not by any way, and utilize narration above to limit the scope of the invention.The professional person of this area, can utilize principle of the present invention, designs various embodiment, and does not exceed scope of the present invention.
Claims (2)
1. detect a method for Aquacoat kinetic viscosity, concrete method is:
Take dry sample 1-~ 10g, add 30 ~ 200g mixed solvent, cover stopper, stir sample is dissolved completely, under 25 ± 0.1 DEG C of water bath with thermostatic control conditions, use No. 0 rotor to measure with rotational viscometer;
Result treatment: viscosity=rotor coefficient × rotating speed, the mean value of getting twice test is end product.
2. a kind of method that detects Aquacoat kinetic viscosity described in, it is characterized in that, described mixed solvent is the conventional organic solvent in this area, is specially one or several potpourris in methyl alcohol, ethanol, ethyl acetate, cyclohexane, benzene, toluene.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410455590.7A CN104198336A (en) | 2014-09-10 | 2014-09-10 | Method for detecting kinetic viscosity of ethylcellulose aqueous dispersion |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410455590.7A CN104198336A (en) | 2014-09-10 | 2014-09-10 | Method for detecting kinetic viscosity of ethylcellulose aqueous dispersion |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104198336A true CN104198336A (en) | 2014-12-10 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201410455590.7A Pending CN104198336A (en) | 2014-09-10 | 2014-09-10 | Method for detecting kinetic viscosity of ethylcellulose aqueous dispersion |
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| CN (1) | CN104198336A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105954148A (en) * | 2016-04-26 | 2016-09-21 | 重庆鹏凯精细化工有限公司 | Method for determination of viscosity generation and dissolution time of dissolution-retarding non-ionic cellulose ether |
| CN110302094A (en) * | 2019-07-16 | 2019-10-08 | 广州艾蓓生物科技有限公司 | A kind of non-sticky cup lip glaze of high glaze and preparation method thereof |
-
2014
- 2014-09-10 CN CN201410455590.7A patent/CN104198336A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105954148A (en) * | 2016-04-26 | 2016-09-21 | 重庆鹏凯精细化工有限公司 | Method for determination of viscosity generation and dissolution time of dissolution-retarding non-ionic cellulose ether |
| CN110302094A (en) * | 2019-07-16 | 2019-10-08 | 广州艾蓓生物科技有限公司 | A kind of non-sticky cup lip glaze of high glaze and preparation method thereof |
| CN110302094B (en) * | 2019-07-16 | 2022-03-29 | 广州艾蓓生物科技有限公司 | High-gloss non-stick lip glaze and preparation method thereof |
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Legal Events
| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20141210 |
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| WD01 | Invention patent application deemed withdrawn after publication |