CN104188919B - A kind of livestock and poultry Thiamphenicol dried bean noodles supensoid agent and preparation method thereof - Google Patents
A kind of livestock and poultry Thiamphenicol dried bean noodles supensoid agent and preparation method thereof Download PDFInfo
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- CN104188919B CN104188919B CN201410497406.5A CN201410497406A CN104188919B CN 104188919 B CN104188919 B CN 104188919B CN 201410497406 A CN201410497406 A CN 201410497406A CN 104188919 B CN104188919 B CN 104188919B
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Abstract
The invention belongs to a kind of livestock and poultry Thiamphenicol dried bean noodles supensoid agent and preparation method thereof, livestock and poultry Thiamphenicol dried bean noodles supensoid agent, is made up of the raw material of following portions by weight：5 ~ 10 parts of Thiamphenicol, 5 ~ 30 parts of sodium citrate, 10 ~ 15 parts of suspending agent, 1 ~ 10 part of wetting agent, 30 ~ 60 parts of starch, 0.5 ~ 1 part of flavouring.The beneficial effect comprise that, dry suspensoid agent is made into by the stabilizer for adding appropriate in Thiamphenicol, significantly increase the hydrophily of medicine, improve dispersiveness of the Thiamphenicol in water, allow medicine dispersed for a long time in water, hence it is evident that to add the bioavilability of medicine.
Description
Technical field
The present invention relates to technical field of animal remedy preparation, and in particular to a kind of livestock and poultry Thiamphenicol dried bean noodles supensoid agent and its system
Preparation Method.
Background technology
The antimicrobial spectrum and antibacterial action and chloramphenicol of Thiamphenicol are similar, tool broad spectrum antimicrobial effect, including aerobic leather
Blue negative bacterium and gram positive bacteria, anaerobic bacteria, rickettsiae, Chlamydia, conveyor screw.Thiamphenicol has to following bacterium sterilizes
Effect：Haemophilus influenzae, streptococcus pneumonia and Neisseria meningitidis.Only has bacteriostasis to following bacterium：Golden yellow grape
Coccus, micrococcus scarlatinae, Streptococcus viridans, B groups hemolytic streptococcus, EHEC, Klebsiella Pneumoniae, unusual change
The anaerobic bacterias such as shape bacillus, Salmonella typhi, bacillus paratyphosus, Shigella, bacteroides fragilis.But Thiamphenicol is insoluble in
Water, it can only be administered by spice, the amount of labour is big, and the uneven phenomenon of mixing easily occurs.
The content of the invention
It is an object of the invention to provide it is a kind of can in water it is dispersed and keep stable livestock and poultry mould with MSM for a long time
Plain dried bean noodles supensoid agent and preparation method thereof.
To achieve the above object, the technical solution adopted by the present invention is a kind of livestock and poultry Thiamphenicol dried bean noodles supensoid agent, by
The raw material of following portions by weight is made：5~10 parts of Thiamphenicol, 5~30 parts of sodium citrate, 10~15 parts of suspending agent, wetting agent 1
~10 parts, 30~60 parts of starch, 0.5~1 part of flavouring.
Preferably, livestock and poultry Thiamphenicol dried bean noodles supensoid agent, is made up of the raw material of following portions by weight：Thiamphenicol
5.5 parts, 10 parts of wetting agent, 10 parts of suspending agent, 25 parts of sodium citrate, 49 parts of starch, 0.5 part of flavouring.
Described suspending agent is hydroxypropyl methylcellulose, agar, PVP (PVPk17), carboxymethyl cellulose
One or more in sodium, xanthans, guar gum, gelatin.
Described wetting agent is the one or more in sodium alginate, poloxamer, polysorbate60, dodecyl sodium sulfate.
Described flavouring is milk flavour.
The described livestock and poultry preparation method of Thiamphenicol dried bean noodles supensoid agent, comprises the following steps：(1) respectively according to described
Weight proportion weigh Thiamphenicol, wetting agent, suspending agent, sodium citrate put in baking oven dry after mixed
Thing, crush, cross 200 mesh sieves, it is standby；(2) mixture after above-mentioned sieving and starch are well mixed, add 50~70% (bodies
Fraction) ethanol, granulation, be subsequently placed in 50 DEG C of baking ovens and dry, add flavouring mixing.
The beneficial effect comprise that it is made into dry-mixed hang by adding appropriate stabilizer in Thiamphenicol
Agent, the hydrophily of medicine is significantly increased, improve dispersiveness of the Thiamphenicol in water, allow medicine long-time in water
It is dispersed, hence it is evident that to add the bioavilability of medicine, and ensure that good palatability, change the administration of this medicine
Mode, the amount of labour is alleviated, while improve the drug effect of medicine, reduce usage amount, improve the clinical effectiveness of medicine, saved
Feeding cost.
Embodiment
With reference to specific embodiment, the invention will be further described, but protection scope of the present invention not limited to this.
Embodiment 1
A kind of livestock and poultry use Thiamphenicol dried bean noodles supensoid agent, are made up of the raw material of following portions by weight：Thiamphenicol 5.5
Part, 10 parts of poloxamer, 10 parts of xanthans, 25 parts of sodium citrate, 49 parts of starch, 0.5 part of milk flavour.
The livestock and poultry use the preparation method of Thiamphenicol dried bean noodles supensoid agent, comprise the following steps：(1) respectively according to described
Weight proportion weigh Thiamphenicol, poloxamer, xanthans, sodium citrate put in baking oven dry after mixed
Thing, crush, cross 200 mesh sieves, it is standby；(2) mixture after above-mentioned sieving and starch are well mixed, add 60% (volume integral
Number) ethanol, granulation, be subsequently placed in 50 DEG C of baking ovens and dry, add milk flavour mixing.
Embodiment 2
A kind of livestock and poultry use Thiamphenicol dried bean noodles supensoid agent, are made up of the raw material of following portions by weight：5 parts of Thiamphenicol,
5 parts of sodium citrate, 10 parts of hydroxypropyl methylcellulose, 1 part of sodium alginate, 30 parts of starch, 0.5 part of milk flavour.
Described livestock and poultry use the preparation method of Thiamphenicol dried bean noodles supensoid agent, comprise the following steps：(1) respectively according to institute
The weight proportion stated weigh Thiamphenicol, hydroxypropyl methylcellulose, sodium alginate, sodium citrate put in baking oven dry after be well mixed
Mixture is obtained, is crushed, crosses 200 mesh sieves, it is standby；(2) mixture after above-mentioned sieving and starch are well mixed, add 70%
The ethanol of (volume fraction), granulation, is subsequently placed in 50 DEG C of baking ovens and dries, and adds milk flavour mixing.
Embodiment 3
A kind of livestock and poultry use Thiamphenicol dried bean noodles supensoid agent, are made up of the raw material of following portions by weight：10 parts of Thiamphenicol,
30 parts of sodium citrate, 15 parts of agar, 10 parts of polysorbate60,60 parts of starch, 1 part of milk flavour.
Described livestock and poultry use the preparation method of Thiamphenicol dried bean noodles supensoid agent, comprise the following steps：(1) respectively according to institute
The weight proportion stated weigh Thiamphenicol, polysorbate60, agar, sodium citrate put in baking oven dry after mixed
Thing, crush, cross 200 mesh sieves, it is standby；(2) said mixture and starch are well mixed, add the second of 50% (volume fraction)
Alcohol, granulation, is subsequently placed in 50 DEG C of baking ovens and dries, and adds milk flavour mixing.
Embodiment 4
A kind of livestock and poultry use Thiamphenicol dried bean noodles supensoid agent, are made up of the raw material of following portions by weight：8 parts of Thiamphenicol,
15 parts of sodium citrate, 13 parts of gelatin, 5 parts of dodecyl sodium sulfate, 45 parts of starch, 0.8 part of milk flavour.
Described livestock and poultry use the preparation method of Thiamphenicol dried bean noodles supensoid agent, comprise the following steps：(1) respectively according to institute
The weight proportion stated weigh Thiamphenicol, dodecyl sodium sulfate, gelatin, sodium citrate put in baking oven dry after be well mixed
To mixture, crush, cross 200 mesh sieves, it is standby；(2) mixture after above-mentioned sieving and starch are well mixed, add 55%
The ethanol of (volume fraction), granulation, is subsequently placed in 50 DEG C of baking ovens and dries, and adds milk flavour mixing.
Embodiment 5
A kind of livestock and poultry use Thiamphenicol dried bean noodles supensoid agent, are made up of the raw material of following portions by weight：7 parts of Thiamphenicol,
10 parts of sodium citrate, 12 parts of PVP (PVPk17), 8 parts of poloxamer, 40 parts of starch, 0.6 part of milk flavour.
Described livestock and poultry use the preparation method of Thiamphenicol dried bean noodles supensoid agent, comprise the following steps：(1) respectively according to institute
The weight proportion stated weigh Thiamphenicol, poloxamer, PVP (PVPk17), sodium citrate put in baking oven do
It is well mixed after dry to obtain mixture, crush, cross 200 mesh sieves, it is standby；(2) mixture after above-mentioned sieving and starch are mixed
Uniformly, the ethanol of 65% (volume fraction) is added, granulation, is subsequently placed in 50 DEG C of baking ovens and dries, adds milk flavour mixing
.
Embodiment 6
A kind of livestock and poultry use Thiamphenicol dried bean noodles supensoid agent, are made up of the raw material of following portions by weight：7 parts of Thiamphenicol,
20 parts of sodium citrate, 11 parts of guar gum, 9 parts of dodecyl sodium sulfate, 50 parts of starch, 0.9 part of milk flavour.
Described livestock and poultry use the preparation method of Thiamphenicol dried bean noodles supensoid agent, comprise the following steps：(1) respectively according to institute
The weight proportion stated weigh Thiamphenicol, dodecyl sodium sulfate, guar gum, sodium citrate put in baking oven dry after be well mixed
Mixture is obtained, is crushed, crosses 200 mesh sieves, it is standby；(2) mixture after above-mentioned sieving and starch are well mixed, add 60%
The ethanol of (volume fraction), granulation, is subsequently placed in 50 DEG C of baking ovens and dries, and adds milk flavour mixing.
Embodiment 7
A kind of livestock and poultry use Thiamphenicol dried bean noodles supensoid agent, are made up of the raw material of following portions by weight：6 parts of Thiamphenicol,
8 parts of sodium citrate, 14 parts of sodium carboxymethylcellulose, 2 parts of poloxamer, 55 parts of starch, 0.75 part of milk flavour.
Described livestock and poultry use the preparation method of Thiamphenicol dried bean noodles supensoid agent, comprise the following steps：(1) respectively according to institute
The weight proportion stated weigh Thiamphenicol, poloxamer, sodium carboxymethylcellulose, sodium citrate put dried in baking oven after mix it is equal
It is even to obtain mixture, crush, cross 200 mesh sieves, it is standby；(2) mixture after above-mentioned sieving and starch are well mixed, added
70% ethanol, granulation, is subsequently placed in 50 DEG C of baking ovens and dries, and adds milk flavour mixing.
Application test
The stability test of preparation：
The livestock and poultry that embodiment 1-3 makes place 6 using Thiamphenicol dried bean noodles supensoid agent under conditions of 40 DEG C, 75% humidity
Individual month, the indexs such as its content, sedimentation volume ratio, redispersibility, moisture are determined, final result is shown in Table 1：
Table 1
As it can be seen from table 1 livestock and poultry prepared by the present invention are not clear using the change of Thiamphenicol dried bean noodles supensoid agent granule content
Aobvious, every Testing index meets regulation, has good stability.
Animal experiment
For chicken in morbidity, it is normal that clinic often shows as feed intake decline drinking-water；When spice is fed, taking the photograph for medicine can be reduced
Enter amount, influence its therapeutic effect.
Experiment is chicken colibacillosis (078 serotype) with strain, is purchased from China Veterinary Drugs Supervisory Inst.；Before use, by chicken large intestine
Bacillus (078 serotype) is trained bacterium solution, 3.1x10 containing viable bacteria in every milliliter of bacterium solution8CFU。
150 blue grey chick in 29 ages in days health sea are taken, are randomly divided into 5 groups, every group 30, specific packet and disposition are shown in
Table 2：
Table 2
Animal feeding and administering mode：Extra large blue grey chick is routinely raised without chicken colibacillosis vaccine immunity before experiment
Complete feed, free choice feeding and drinking-water are fed, and carries out clinical observation.Attacking poison, (every chicken air bag injects 0.6mL chicken colibacillosis bacterium
Liquid) after 4h, Thiamphenicol dry suspensoid agent group (the Thiamphenicol dried bean noodles supensoid agent prepared from embodiment 1, Thiamphenicol 75mg/L
Drinking-water) free water administration；Ofloxacin group is administered by 10mg/kg chickens body weight daily, divides the morning, afternoon 2 times for oral administration；Safety is right
Poison is not attacked according to group, the Thiamphenicol dried bean noodles supensoid agent (Thiamphenicol 250mg/L drinking-water) prepared with embodiment 1 is administered；MSM is mould
The equal continuous use 4d of plain dry suspensoid agent group, ofloxacin group, safe control group；The equal Continuous Observation 16d of each group, records its clinical condition
Shape, cut open inspection is carried out to dead chicken and separates pathogen, judge the cause of the death, experiment is preceding and tests the 16th day time-division also known as amount chicken body weight
And record in detail.
Index of assessment of curative effect
It is dead：All classical symptoms for occurring chicken colibacillosis during experiment are simultaneously dead, and postmortem finds typical cytopathic,
Chicken colibacillosis person is separately cultured out from liver, spleen and heart, it is dead to be judged to infection：Calculated according to dead chicken number each
The group death rate.Cure：All spirit, appetite recover normal after medication during experiment, the clinical symptoms persons such as row's loose stool no longer occur
Category is cured；The ratio that test chicken is accounted for according to healing chicken calculates cure rate.Effectively：It is being cured completely after medication and have clinical condition
Shape but non-the dead are effective：The ratio that the chicken number of every group of survival accounts for test chicken number during off-test is effective percentage.Weightening：According to
The body weight of every chicken calculates the weightening of every chicken and then calculates the flat of every group of test chicken accordingly during on-test and during off-test
Weightening and standard deviation.The ratio between weightening that body weight increase rate is organized by each medication treatment group with health calculates, wherein healthy control group
It is set to 100%.
Test chicken treatment such as table 3
Table 3
Therapeutic test result
Compared with infecting control group, each treatment group chicken clinical symptoms mitigate rapidly.After medication in 16d, each group chicken
The death rate, cure rate, effective percentage and rate of body weight gain are shown in Table 3.From table 3, Thiamphenicol dry suspensoid agent group and ofloxacin group
Extremely significantly, less than infection control group, cure rate pole is significantly higher than the self-healing rate of infection control group to the death rate, efficient also extremely aobvious
Write higher than infection control group.The death rate of Thiamphenicol dry suspensoid agent group is less than ofloxacin group, and cure rate is higher than Ofloxacin
Group, the gaining effect no difference of science of statistics between Thiamphenicol group and ofloxacin group.
Known by result of the test, make safe compare with the dosage of 5 times of Thiamphenicol dry suspensoid agent groups has no compared with health is organized
Adverse reaction, show that wettable Thiamphenicol dried bean noodles supensoid agent to chicken drinking-water is safe and effective to treat chicken colibacillosis
's.
Claims (3)
1. a kind of livestock and poultry Thiamphenicol dried bean noodles supensoid agent, it is characterised in that be made up of the raw material of following portions by weight：MSM is mould
5 ~ 10 parts of element, 5 ~ 30 parts of sodium citrate, 10 ~ 15 parts of suspending agent, 1 ~ 10 part of wetting agent, 30 ~ 60 parts of starch, 0.5 ~ 1 part of flavouring；
Described suspending agent is hydroxypropyl methylcellulose, agar, PVP, sodium carboxymethylcellulose, xanthans, Guar
One or more in glue, gelatin；Described wetting agent is in sodium alginate, poloxamer, polysorbate60, dodecyl sodium sulfate
One or more；Described flavouring is milk flavour.
2. livestock and poultry as claimed in claim 1 Thiamphenicol dried bean noodles supensoid agent, it is characterised in that by the original of following portions by weight
Material is made：5.5 parts of Thiamphenicol, 10 parts of wetting agent, 10 parts of suspending agent, 25 parts of sodium citrate, 49 parts of starch, 0.5 part of flavouring.
3. the livestock and poultry as claimed in claim 1 or 2 preparation method of Thiamphenicol dried bean noodles supensoid agent, it is characterised in that including
Following steps：（1）Weigh after Thiamphenicol, wetting agent, suspending agent, sodium citrate are dried and mix according to described weight proportion respectively
Conjunction uniformly obtains mixture, crushes, sieves for subsequent use；（2）Mixture after above-mentioned sieving and starch are well mixed, use 50%-
70% ethanol spraying granulation, drying, add flavouring mixing.
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