CN104187617A - Health food capable of enhancing immunity and preparation method thereof - Google Patents
Health food capable of enhancing immunity and preparation method thereof Download PDFInfo
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- CN104187617A CN104187617A CN201410366957.8A CN201410366957A CN104187617A CN 104187617 A CN104187617 A CN 104187617A CN 201410366957 A CN201410366957 A CN 201410366957A CN 104187617 A CN104187617 A CN 104187617A
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- ginkgo biloba
- health food
- extract
- biloba extract
- fructus lycii
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- 235000013402 health food Nutrition 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- 230000002708 enhancing effect Effects 0.000 title abstract 3
- 244000197580 Poria cocos Species 0.000 claims abstract description 42
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 42
- 239000000284 extract Substances 0.000 claims abstract description 39
- 239000002775 capsule Substances 0.000 claims abstract description 25
- 238000002137 ultrasound extraction Methods 0.000 claims abstract description 17
- 244000194101 Ginkgo biloba Species 0.000 claims abstract description 13
- 238000000034 method Methods 0.000 claims abstract description 10
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- 229940068052 ginkgo biloba extract Drugs 0.000 claims description 45
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- 239000000203 mixture Substances 0.000 claims description 19
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- 235000008100 Ginkgo biloba Nutrition 0.000 claims description 12
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 claims description 12
- 238000011049 filling Methods 0.000 claims description 11
- 235000011201 Ginkgo Nutrition 0.000 claims description 8
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- 239000000080 wetting agent Substances 0.000 claims description 7
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- LCJVIYPJPCBWKS-NXPQJCNCSA-N thymosin Chemical compound SC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(O)=O)C(O)=O LCJVIYPJPCBWKS-NXPQJCNCSA-N 0.000 description 2
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- 241000576755 Sclerotia Species 0.000 description 1
- 241000233782 Smilacaceae Species 0.000 description 1
- 241000362909 Smilax <beetle> Species 0.000 description 1
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- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 description 1
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- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Botany (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a health food capable of enhancing immunity and a preparation method thereof, which belong to the field of health food. According to a formula, the health food comprises the following ingredients in parts by weight: 30-50 parts of fructus lycii extracts, 30-50 parts of poria cocos extracts, and 10-30 parts of gingko flavonoids. According to the invention, three kinds of Chinese herb extracts are extracted by using a new ultrasonic extraction method, and then the three kinds of Chinese herb extracts are compatibly used and cooperatively acted, so that the health food plays a role in enhancing immunity better. The health food emphatically takes the crowd as the research object, and selects a capsule as a dosage form of products by taking function, absorption and stability and the like into consideration, therefore, the health food has the characteristics of high bioavailability, easiness for taking, and the like.
Description
Technical field
The present invention relates to a kind of health food, especially a kind ofly take Chinese herbal medicine and can improve health food of immunity and preparation method thereof as what raw material was made.
Background technology
Immunity is the defense mechanism of human body self, is human body identification and any foreign matter (virus, bacterium etc.) of eliminating external intrusion; Process the ability of self cell and identification and processing vivo mutations cell and the virus infected cell of old and feeble, damage, dead, sex change.Modern immunology thinks, immunity is human body identification and the physiological reaction of getting rid of " dissident ".From color therapy, human body needs the light wave of various frequency 300 ~ 700 nanometers, maintains healthy and existence.
Immunity can be divided into two classes: the 1. innate immunity: the innate immunity (Natural immunity), claim again congenital immunity, and refer to that a people or Yi Ge colony have an instinct for the immunity having.A lot of diseases are that domestic or wild animal all can infect, but the mankind but have natural immunity to these diseases; And the contagious a lot of diseases of the mankind, some animal but has immunity.Certain race of the mankind may have immunity to some disease, but other races may just be infected than being easier to.In agnate people, perhaps someone has immunity to a kind of disease, and agnate other people be easily infected.2. acquired immunity: acquired immunity (Acquired immunity), claim again acquired immunity, be in life process, naturally to obtain after people is born, or with passive the obtaining of method of human assistance.Refer to that antibody, protein in blood produce, and can hit the antigen (antigen) (foreign substance) in health.Every kind of antibody can only be protected a kind of antigen of body-defence.Antibody belongs to the immune system part of health.Immune other parts comprise marrow, and marrow is various leukocytic for manufacturing, and leucocyte protection health is avoided bacterium and infected; Lymph gland is leukocytic for manufacturing, and these leucocytes produce antibody in turn; Thymus gland is used for manufacturing thymosin extrasin, and thymosin extrasin is a kind of hormone that stimulates some leucocyte maturation; Be used for regulating cell factor and the protein of multiple leucocyte activity.Acquired immunity power can be initiatively, can be also passive.
The performance of hypoimmunity: it is exactly liable to illness that hypoimmunity the most directly shows.Because of often ill, increased the weight of the consumption of body, thus generally have a delicate constitution, the performance such as malnutritive, One's spirits are drooping, fatigue and weak, appetite reduction, sleep-disorder, sick, have an injection and take medicine the normal potluck that just gets married.Each sickly all will could recover for a long time, and usually outbreak repeatedly.If things go on like this can cause health and intelligence development bad, also easily bring out major disease.
Along with the develop rapidly of China's economy, the raising of national life level, people's health care consciousness is more and more stronger, and suitably taking some health food disease preventing and treating and keeping fit becomes the people of the world's important means.Plant extracts appears at health products trade more and more in recent years, how to extract efficiently separation, improves extract quality and output and by insider, is paid close attention to.And ultrasonic extraction can effectively improve extraction separation rate, shorten extraction time, cost-saving, the Quality and yield that even can also improve product, this emerging extraction method will have very large prospect in field of plant extraction.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, provide a kind of include Fructus lycii P.E, tuckahoe extracts, GINKGO BILOBA EXTRACT can improve health food of immunity and preparation method thereof.
The object of the present invention is achieved like this: a kind ofly can improve immunity health food, its constituent comprises (weight portion): Fructus lycii P.E: 30~50 parts, tuckahoe extracts: 30~50 parts, GINKGO BILOBA EXTRACT: 10~30 parts, the significant composition of described Fructus lycii P.E is LBP-X, the content of this LBP-X is not less than 30.0%, and component is in detail:
LBP-X >=30.0%;
Moisture≤5.0%;
Ash content≤5.0%;
Heavy metal≤10mg/kg;
Arsenic (in As)≤1.0mg/kg;
Plumbous (in Pb)≤2.0mg/kg;
The significant composition of described tuckahoe extracts is pachymaran, and the content of this pachymaran is not less than 20.0%, and component is in detail:
Pachymaran >=20.0%;
Moisture≤8.0%;
Ash content≤6.0%;
Heavy metal≤10mg/kg;
Arsenic (in As)≤0.5mg/kg;
Plumbous (in Pb)≤1.0mg/kg;
Copper (in Au)≤10.0mg/kg;
Sulfur dioxide residual quantity≤150mg/kg;
Described GINKGO BILOBA EXTRACT is ginkgo biloba p.e, and the content of this GINKGO BILOBA EXTRACT is not less than 24.0%, and component is in detail:
GINKGO BILOBA EXTRACT >=24.0%;
Moisture≤5.0%;
Heavy metal≤10mg/kg;
Arsenic (in As)≤1.0mg/kg;
Residue on ignition≤0.8%.
Further, optimization formula composition weight portion of the present invention is: 40 parts, and tuckahoe extracts: 40 parts, GINKGO BILOBA EXTRACT: 20 parts, the significant composition of described Fructus lycii P.E is LBP-X, and the content of this LBP-X is not less than 30.0%, component is in detail:
LBP-X >=30.0%;
Moisture≤5.0%;
Ash content≤5.0%;
Heavy metal≤10mg/kg;
Arsenic (in As)≤1.0mg/kg;
Plumbous (in Pb)≤2.0mg/kg;
The significant composition of described tuckahoe extracts is pachymaran, and the content of this pachymaran is not less than 20.0%, and component is in detail:
Pachymaran >=20.0%;
Moisture≤8.0%;
Ash content≤6.0%;
Heavy metal≤10mg/kg;
Arsenic (in As)≤0.5mg/kg;
Plumbous (in Pb)≤1.0mg/kg;
Copper (in Au)≤10.0mg/kg;
Sulfur dioxide residual quantity≤150mg/kg;
Described GINKGO BILOBA EXTRACT is ginkgo biloba p.e, and the content of this GINKGO BILOBA EXTRACT is not less than 24.0%, and component is in detail:
GINKGO BILOBA EXTRACT >=24.0%;
Moisture≤5.0%;
Heavy metal≤10mg/kg;
Arsenic (in As)≤1.0mg/kg;
Residue on ignition≤0.8%.
The present invention is a kind of can improve immunity health food, is made into capsule.
The present invention can improve the raw material disposal method of the health food of immunity, it is characterized in that its technique comprises the following steps:
1, the preparation of Fructus lycii P.E: the fruit of Chinese wolfberry being cleaned and dried, pulverize, cross 50~60 mesh sieves, is 40kHz in supersonic frequency, power is 200w, and temperature is 60 ℃, and 70% the ethanol of take is to extract solvent, solid-liquid ratio is 1:20, ultrasonic extraction 30min, and then centrifugal concentrating is dried to obtain LBP-X;
2, the preparation of tuckahoe extracts: Poria cocos being cleaned and dried, pulverize, cross 20~60 mesh sieves, is 40kHz in supersonic frequency, power is 320w, and 70% the ethanol of take is to extract solvent, and solid-liquid ratio is 1:10, temperature is 25 ℃, ultrasonic extraction 20min, and then centrifugal concentrating is dried to obtain pachymaran;
3, the preparation of GINKGO BILOBA EXTRACT: ginkgo leaf being cleaned and to be dried, pulverize, cross 50~60 mesh sieves, is 40kHz in supersonic frequency, and power is 320w, and temperature is 30 ℃, 70% the ethanol of take is to extract solvent, solid-liquid ratio is 1:15, ultrasonic extraction 10min.Repeat to extract twice, then centrifugal concentrating is dried to obtain GINKGO BILOBA EXTRACT.
A kind of preparation method that can improve immunity health food of the present invention, comprises following processing step:
1, by Fructus lycii P.E recited above, tuckahoe extracts, GINKGO BILOBA EXTRACT, will check in accordance with regulations, qualified Fructus lycii P.E, tuckahoe extracts, GINKGO BILOBA EXTRACT are standby;
2, mixing of materials:, drop in blender after Fructus lycii P.E, tuckahoe extracts, GINKGO BILOBA EXTRACT batching by the proportioning described in claim 1, mix 25~35min;
3, granulate: with wetting agent softwood processed, cross 20~28 mesh sieve wet granular processed;
4, dry: wet granular is in 50 ℃~70 ℃ heated-air dryings;
5, whole grain: dry particle is crossed the whole grain of 18~22 mesh sieves;
6, manufactured goods: filling capsule, every dose of content 0.25~0.35g;
7, packing warehouse-in.
Further, described wetting agent is that 5% polyethylene adjoins pyrrolidone (PVPK30) ethanolic solution.
The present invention in conjunction with physicochemical property, considers from function, absorption, stability etc. are many-sided, selects capsule, tablet, granule all to can be used as product forms.Take crowd emphatically as research object, then make capsule as the formulation of product through rational technique, there is the features such as bioavilability is high, taking convenience.
Matrimony vine is the plant of eggplant order Solanaceae Lycium (Lycium), and fruit claims the fruit of Chinese wolfberry, and tender leaf claims matrimony vine head, and frequent species is matrimony vine (Lycium chinense Miller), and main medicinal kind is lycium barbarum (Lycium barbarum L.).Matrimony vine has the blood sugar of reduction, lipotropy, and can antiatherosclerosis.
Poria cocos, claims that again jade is clever, Fu is clever, Wan Linggui, Fu Tu.The dry sclerotia of Shi Ni shelf fungus section fungi Poria cocos, often colonizes on pine roots, and shape is as sweet potato, spherical, crust light brown or pitchy, and inner pink colour or white, be called PORIA ALBA or cloud Siberian cocklebur after refining.Poria cocos is similar to smilax title, therefore easily mixed.Smilax is the root of Smilacaceae plant smilacis glabra (Smilax glabra), and crust yellowish-brown or taupe are completely irrelevant with Poria cocos.Poria cocos slightly sweet flavor is flat, enters the heart, lung, the spleen channel.There is eliminating dampness and diuresis, strengthening the spleen and stomach, the effect of antitoxic heart-soothing and sedative.
Ginkgo leaf (formal name used at school: Ginkgo biloba) be a kind of plant with very high medical value.Ginkgo, another name gingko, Gong Sunshu, belong to gymnosperm, and its fellow disciple's every other plant all becomes extinct, is called as " Relict Plant ".Ginkgo leaf be recognized in the worldly control, the optimal pharmaceutical compositions of anti-cardiovascular and cerebrovascular disease.Mildly bitter flavor, property is flat, there is the beneficial heart, promoting blood circulation and stopping pain, astringe the lung relieving asthma, the effect of dampness elimination antidiarrheal.
The specific embodiment
Below in conjunction with embodiment, the invention will be further described.
Embodiment 1:
1. prepare according to the following steps Fructus lycii P.E, tuckahoe extracts, GINKGO BILOBA EXTRACT:
(1) preparation of Fructus lycii P.E: the fruit of Chinese wolfberry being cleaned and dried, pulverize, cross 50~60 mesh sieves, is 40kHz in supersonic frequency, power is 200w, and temperature is 60 ℃, and 70% the ethanol of take is to extract solvent, solid-liquid ratio is 1:20, ultrasonic extraction 30min, and then centrifugal concentrating is dried to obtain LBP-X;
(2) preparation of tuckahoe extracts: Poria cocos being cleaned and dried, pulverize, cross 20~60 mesh sieves, is 40kHz in supersonic frequency, power is 320w, and 70% the ethanol of take is to extract solvent, and solid-liquid ratio is 1:10, temperature is 25 ℃, ultrasonic extraction 20min, and then centrifugal concentrating is dried to obtain pachymaran;
(3) preparation of GINKGO BILOBA EXTRACT: ginkgo leaf is cleaned and dried, pulverize, crossing 50~60 mesh sieves, is 40kHz in supersonic frequency, and power is 320w, temperature is 30 ℃, 70% the ethanol of take is to extract solvent, and solid-liquid ratio is 1:15, ultrasonic extraction 10min, repeat to extract twice, then centrifugal concentrating is dried to obtain GINKGO BILOBA EXTRACT.
2. by following requirement check Fructus lycii P.E, tuckahoe extracts, GINKGO BILOBA EXTRACT, qualified is standby;
Each composition of Fructus lycii P.E requires:
LBP-X >=30.0%, moisture≤5.0%, ash content≤5.0%, heavy metal≤10mg/kg, arsenic (in As)≤1.0mg/kg, plumbous (in Pb)≤2.0mg/kg;
Each composition of tuckahoe extracts requires:
Pachymaran >=20.0%, moisture≤8.0%, ash content≤6.0%, arsenic (in As)≤0.5mg/kg, plumbous (in Pb)≤1.0mg/kg, copper (in Au)≤10.0mg/kg, sulfur dioxide residual quantity≤150mg/kg;
Each composition of ginkgo biloba extract requires:
GINKGO BILOBA EXTRACT >=24.0%, moisture≤5.0%, heavy metal≤10mg/kg, arsenic (in As)≤1.0mg/kg, residue on ignition≤0.8%.
3. extract Fructus lycii P.E 40g, tuckahoe extracts 40g, GINKGO BILOBA EXTRACT 20g, in 300,000 grades of clean areas, drops in V-type blender, mixes 30min, guarantees evenly.
4. in 300,000 grades of clean areas, take 5% polyvinylpyrrolidone (PVPK30) as wetting agent softwood processed, cross 24 mesh sieve wet granular processed.
5. in 300,000 grades of clean areas, wet granular is in 60 ℃ of heated-air dryings.
6. in 300,000 grades of clean areas, dry particle is crossed the whole grain of 20 mesh sieves.
7. capsule is filling: in 300,000 grades of clean areas, with capsule filler filling capsule, every capsules content 0.30g, should note monitoring product content uniformity during filling, is controlled in disparity range.
8. capsule polishing: in 300,000 grades of clean areas, remove the fine powder that sticks to capsule surface with polishing machine, sieve removes defective work simultaneously.
9. inner packing: in 300,000 grades of clean areas, inner packing adopts the oral stable medicinal polythene bottle with high density packing that meets YBB00122002 standard-required, 100 every bottle.
10. external packing: middle package paper box, 1 bottle, every box, large packing adopts corrugated case.
11. checks: check according to related standards.
12. warehouse-ins: product is through putting in storage after the assay was approved.
Embodiment 2:
1. prepare according to the following steps Fructus lycii P.E, tuckahoe extracts, GINKGO BILOBA EXTRACT:
(1) preparation of Fructus lycii P.E: the fruit of Chinese wolfberry being cleaned and dried, pulverize, cross 50~60 mesh sieves, is 40kHz in supersonic frequency, power is 200w, and temperature is 60 ℃, and 70% the ethanol of take is to extract solvent, solid-liquid ratio is 1:20, ultrasonic extraction 30min, and then centrifugal concentrating is dried to obtain LBP-X;
(2) preparation of tuckahoe extracts: Poria cocos being cleaned and dried, pulverize, cross 20~60 mesh sieves, is 40kHz in supersonic frequency, power is 320w, and 70% the ethanol of take is to extract solvent, and solid-liquid ratio is 1:10, temperature is 25 ℃, ultrasonic extraction 20min, and then centrifugal concentrating is dried to obtain pachymaran;
(3) preparation of GINKGO BILOBA EXTRACT: ginkgo leaf is cleaned and dried, pulverize, crossing 50~60 mesh sieves, is 40kHz in supersonic frequency, and power is 320w, temperature is 30 ℃, 70% the ethanol of take is to extract solvent, and solid-liquid ratio is 1:15, ultrasonic extraction 10min, repeat to extract twice, then centrifugal concentrating is dried to obtain GINKGO BILOBA EXTRACT.
2. by following requirement check Fructus lycii P.E, tuckahoe extracts, GINKGO BILOBA EXTRACT, qualified is standby;
Each composition of Fructus lycii P.E requires:
LBP-X >=30.0%, moisture≤5.0%, ash content≤5.0%, heavy metal≤10mg/kg, arsenic (in As)≤1.0mg/kg, plumbous (in Pb)≤2.0mg/kg;
Each composition of tuckahoe extracts requires:
Pachymaran >=20.0%, moisture≤8.0%, ash content≤6.0%, arsenic (in As)≤0.5mg/kg, plumbous (in Pb)≤1.0mg/kg, copper (in Au)≤10.0mg/kg, sulfur dioxide residual quantity≤150mg/kg;
Each composition of ginkgo biloba extract requires:
GINKGO BILOBA EXTRACT >=24.0%, moisture≤5.0%, heavy metal≤10mg/kg, arsenic (in As)≤1.0mg/kg, residue on ignition≤0.8%.
3. extract Fructus lycii P.E 30g, tuckahoe extracts 30g, GINKGO BILOBA EXTRACT 10g, in 300,000 grades of clean areas, drops in V-type blender, mixes 25min, guarantees evenly.
4. in 300,000 grades of clean areas, take 5% polyvinylpyrrolidone (PVPK30) as wetting agent softwood processed, cross 20 mesh sieve wet granular processed.
5. in 300,000 grades of clean areas, wet granular is in 50 ℃ of heated-air dryings.
6. in 300,000 grades of clean areas, dry particle is crossed the whole grain of 18 mesh sieves.
7. capsule is filling: in 300,000 grades of clean areas, with capsule filler filling capsule, every capsules content 0.25g, should note monitoring product content uniformity during filling, is controlled in disparity range.
8. capsule polishing: in 300,000 grades of clean areas, remove the fine powder that sticks to capsule surface with polishing machine, sieve removes defective work simultaneously.
9. inner packing: in 300,000 grades of clean areas, inner packing adopts the oral stable medicinal polythene bottle with high density packing that meets YBB00122002 standard-required, 120 every bottle.
10. external packing: middle package paper box, 1 bottle, every box, large packing adopts corrugated case.
11. checks: check according to related standards.
12. warehouse-ins: product is through putting in storage after the assay was approved.
Embodiment 3:
1. prepare according to the following steps Fructus lycii P.E, tuckahoe extracts, GINKGO BILOBA EXTRACT:
(1) preparation of Fructus lycii P.E: the fruit of Chinese wolfberry being cleaned and dried, pulverize, cross 50~60 mesh sieves, is 40kHz in supersonic frequency, power is 200w, and temperature is 60 ℃, and 70% the ethanol of take is to extract solvent, solid-liquid ratio is 1:20, ultrasonic extraction 30min, and then centrifugal concentrating is dried to obtain LBP-X;
(2) preparation of tuckahoe extracts: Poria cocos being cleaned and dried, pulverize, cross 20~60 mesh sieves, is 40kHz in supersonic frequency, power is 320w, and 70% the ethanol of take is to extract solvent, and solid-liquid ratio is 1:10, temperature is 25 ℃, ultrasonic extraction 20min, and then centrifugal concentrating is dried to obtain pachymaran;
(3) preparation of GINKGO BILOBA EXTRACT: ginkgo leaf is cleaned and dried, pulverize, crossing 50~60 mesh sieves, is 40kHz in supersonic frequency, and power is 320w, temperature is 30 ℃, 70% the ethanol of take is to extract solvent, and solid-liquid ratio is 1:15, ultrasonic extraction 10min, repeat to extract twice, then centrifugal concentrating is dried to obtain GINKGO BILOBA EXTRACT.
2. by following requirement check Fructus lycii P.E, tuckahoe extracts, GINKGO BILOBA EXTRACT, qualified is standby;
Each composition of Fructus lycii P.E requires:
LBP-X >=30.0%, moisture≤5.0%, ash content≤5.0%, heavy metal≤10mg/kg, arsenic (in As)≤1.0mg/kg, plumbous (in Pb)≤2.0mg/kg;
Each composition of tuckahoe extracts requires:
Pachymaran >=20.0%, moisture≤8.0%, ash content≤6.0%, arsenic (in As)≤0.5mg/kg, plumbous (in Pb)≤1.0mg/kg, copper (in Au)≤10.0mg/kg, sulfur dioxide residual quantity≤150mg/kg;
Each composition of ginkgo biloba extract requires:
GINKGO BILOBA EXTRACT >=24.0%, moisture≤5.0%, heavy metal≤10mg/kg, arsenic (in As)≤1.0mg/kg, residue on ignition≤0.8%.
3. extract Fructus lycii P.E 50g, tuckahoe extracts 50g, GINKGO BILOBA EXTRACT 30g, in 300,000 grades of clean areas, drops in V-type blender, mixes 35min, guarantees evenly.
4. in 300,000 grades of clean areas, take 5% polyvinylpyrrolidone (PVPK30) as wetting agent softwood processed, cross 28 mesh sieve wet granular processed.
5. in 300,000 grades of clean areas, wet granular is in 70 ℃ of heated-air dryings.
6. in 300,000 grades of clean areas, dry particle is crossed the whole grain of 22 mesh sieves.
7. capsule is filling: in 300,000 grades of clean areas, with capsule filler filling capsule, every capsules content 0.35g, should note monitoring product content uniformity during filling, is controlled in disparity range.
8. capsule polishing: in 300,000 grades of clean areas, remove the fine powder that sticks to capsule surface with polishing machine, sieve removes defective work simultaneously.
9. inner packing: in 300,000 grades of clean areas, inner packing adopts the oral stable medicinal polythene bottle with high density packing that meets YBB00122002 standard-required, 60 every bottle.
10. external packing: middle package paper box, 1 bottle, every box, large packing adopts corrugated case.
11. checks: check according to related standards.
12. warehouse-ins: product is through putting in storage after the assay was approved.
Claims (6)
1. the health food that can improve immunity, it is characterized in that its formula components is for (weight portion): Fructus lycii P.E: 30~50 parts, tuckahoe extracts: 30~50 parts, GINKGO BILOBA EXTRACT: 10~30 parts, the significant composition of described Fructus lycii P.E is LBP-X, the content of this LBP-X is not less than 30.0%, and component is in detail:
LBP-X >=30.0%;
Moisture≤5.0%;
Ash content≤5.0%;
Heavy metal≤10mg/kg;
Arsenic (in As)≤1.0mg/kg;
Plumbous (in Pb)≤2.0mg/kg;
The significant composition of described tuckahoe extracts is pachymaran, and the content of this pachymaran is not less than 20.0%, and component is in detail:
Pachymaran >=20.0%;
Moisture≤8.0%;
Ash content≤6.0%;
Heavy metal≤10mg/kg;
Arsenic (in As)≤0.5mg/kg;
Plumbous (in Pb)≤1.0mg/kg;
Copper (in Au)≤10.0mg/kg;
Sulfur dioxide residual quantity≤150mg/kg;
Described GINKGO BILOBA EXTRACT is ginkgo biloba p.e, and the content of this GINKGO BILOBA EXTRACT is not less than 24.0%, and component is in detail:
GINKGO BILOBA EXTRACT >=24.0%;
Moisture≤5.0%;
Heavy metal≤10mg/kg;
Arsenic (in As)≤1.0mg/kg;
Residue on ignition≤0.8%.
2. the health food that can improve immunity according to claim 1, is characterized in that its formula components is for (weight portion): Fructus lycii P.E: 40 parts, and tuckahoe extracts: 40 parts, GINKGO BILOBA EXTRACT: 20 parts.
3. the health food that can improve immunity according to claim 1, is characterized in that this health food to make capsule.
4. can improve health food and the raw material disposal method thereof of immunoregulation capability, it is characterized in that its technique comprises the following steps:
(1) preparation of Fructus lycii P.E: the fruit of Chinese wolfberry being cleaned and dried, pulverize, cross 50~60 mesh sieves, is 40kHz in supersonic frequency, power is 200w, and temperature is 60 ℃, and 70% the ethanol of take is to extract solvent, solid-liquid ratio is 1:20, ultrasonic extraction 30min, and then centrifugal concentrating is dried to obtain LBP-X;
(2) preparation of tuckahoe extracts: Poria cocos being cleaned and dried, pulverize, cross 20~60 mesh sieves, is 40kHz in supersonic frequency, power is 320w, and 70% the ethanol of take is to extract solvent, and solid-liquid ratio is 1:10, temperature is 25 ℃, ultrasonic extraction 20min, and then centrifugal concentrating is dried to obtain pachymaran;
(3) preparation of GINKGO BILOBA EXTRACT: ginkgo leaf is cleaned and dried, pulverize, crossing 50~60 mesh sieves, is 40kHz in supersonic frequency, and power is 320w, temperature is 30 ℃, 70% the ethanol of take is to extract solvent, and solid-liquid ratio is 1:15, ultrasonic extraction 10min, repeat to extract twice, then centrifugal concentrating is dried to obtain GINKGO BILOBA EXTRACT.
5. one kind can be improved health food of immunity and preparation method thereof, it is characterized in that its technique comprises the following steps:
(1) by Fructus lycii P.E claimed in claim 1, tuckahoe extracts, GINKGO BILOBA EXTRACT, will check in accordance with regulations, qualified Fructus lycii P.E, tuckahoe extracts, GINKGO BILOBA EXTRACT are standby;
(2) mixing of materials:, drop in blender after Fructus lycii P.E, tuckahoe extracts, GINKGO BILOBA EXTRACT batching by the proportioning described in claim 1, mix 25~35min;
(3) granulate: with wetting agent softwood processed, cross 20~28 mesh sieve wet granular processed;
(4) dry: wet granular is in 50 ℃~70 ℃ heated-air dryings;
(5) whole grain: dry particle is crossed the whole grain of 18~22 mesh sieves;
(6) manufactured goods: filling capsule, every dose of content 0.25~0.35g;
(7) packing warehouse-in.
6. according to claim 5ly can improve health food of immunity and preparation method thereof, it is characterized in that described wetting agent is 5% polyvinylpyrrolidone PVPK30 ethanolic solution.
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