CN104186524B - Containing the bactericidal composition of poly hexamethylene biguanide or its salt - Google Patents
Containing the bactericidal composition of poly hexamethylene biguanide or its salt Download PDFInfo
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- CN104186524B CN104186524B CN201410441238.8A CN201410441238A CN104186524B CN 104186524 B CN104186524 B CN 104186524B CN 201410441238 A CN201410441238 A CN 201410441238A CN 104186524 B CN104186524 B CN 104186524B
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- hexamethylene biguanide
- poly hexamethylene
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- 239000000203 mixture Substances 0.000 title claims abstract description 71
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 title claims abstract description 51
- 229920002413 Polyhexanide Polymers 0.000 title claims abstract description 51
- 150000003839 salts Chemical class 0.000 title claims abstract description 26
- 230000000844 anti-bacterial effect Effects 0.000 title description 11
- 201000010099 disease Diseases 0.000 claims abstract description 37
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 37
- 235000007164 Oryza sativa Nutrition 0.000 claims abstract description 18
- 235000009566 rice Nutrition 0.000 claims abstract description 18
- OICGFSUWXCJLCO-UHFFFAOYSA-N 1-ethylsulfonylsulfanylethane Chemical group CCSS(=O)(=O)CC OICGFSUWXCJLCO-UHFFFAOYSA-N 0.000 claims abstract description 14
- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 claims abstract description 14
- 235000002566 Capsicum Nutrition 0.000 claims abstract description 13
- 241000196324 Embryophyta Species 0.000 claims abstract description 12
- 241000700605 Viruses Species 0.000 claims abstract description 10
- 241000207199 Citrus Species 0.000 claims abstract description 7
- 239000006002 Pepper Substances 0.000 claims abstract description 7
- 235000016761 Piper aduncum Nutrition 0.000 claims abstract description 7
- 235000017804 Piper guineense Nutrition 0.000 claims abstract description 7
- 235000008184 Piper nigrum Nutrition 0.000 claims abstract description 7
- 235000020971 citrus fruits Nutrition 0.000 claims abstract description 7
- 239000004563 wettable powder Substances 0.000 claims abstract description 7
- 239000000375 suspending agent Substances 0.000 claims abstract description 6
- 241000233866 Fungi Species 0.000 claims abstract description 5
- 230000001580 bacterial effect Effects 0.000 claims abstract description 5
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000004562 water dispersible granule Substances 0.000 claims abstract description 5
- 229910019142 PO4 Inorganic materials 0.000 claims abstract description 4
- 239000010452 phosphate Substances 0.000 claims abstract description 4
- 241000894006 Bacteria Species 0.000 claims abstract description 3
- 239000004480 active ingredient Substances 0.000 claims abstract description 3
- 239000004530 micro-emulsion Substances 0.000 claims abstract description 3
- 244000241235 Citrullus lanatus Species 0.000 claims abstract 4
- 240000007594 Oryza sativa Species 0.000 claims abstract 4
- 244000203593 Piper nigrum Species 0.000 claims abstract 2
- -1 biguanides phosphate Chemical class 0.000 claims description 14
- 240000008574 Capsicum frutescens Species 0.000 claims description 6
- 239000001390 capsicum minimum Substances 0.000 claims description 6
- 125000004836 hexamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 229940123208 Biguanide Drugs 0.000 claims description 3
- 238000005507 spraying Methods 0.000 claims description 3
- AVWOEAVWVDLXMA-UHFFFAOYSA-N 1-(diaminomethylidene)guanidine;nitric acid Chemical compound O[N+]([O-])=O.NC(N)=NC(N)=N AVWOEAVWVDLXMA-UHFFFAOYSA-N 0.000 claims description 2
- RXGSAYBOEDPICZ-UHFFFAOYSA-N 2-[6-[[amino-(diaminomethylideneamino)methylidene]amino]hexyl]-1-(diaminomethylidene)guanidine Chemical compound NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)N RXGSAYBOEDPICZ-UHFFFAOYSA-N 0.000 claims description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 2
- 240000008067 Cucumis sativus Species 0.000 claims description 2
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 claims description 2
- 241000220225 Malus Species 0.000 claims description 2
- 235000011430 Malus pumila Nutrition 0.000 claims description 2
- 235000015103 Malus silvestris Nutrition 0.000 claims description 2
- 241000220324 Pyrus Species 0.000 claims description 2
- 235000021307 Triticum Nutrition 0.000 claims description 2
- 244000098338 Triticum aestivum Species 0.000 claims description 2
- 235000009754 Vitis X bourquina Nutrition 0.000 claims description 2
- 235000012333 Vitis X labruscana Nutrition 0.000 claims description 2
- 240000006365 Vitis vinifera Species 0.000 claims description 2
- 235000014787 Vitis vinifera Nutrition 0.000 claims description 2
- 235000021017 pears Nutrition 0.000 claims description 2
- 241000675108 Citrus tangerina Species 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 1
- 239000005820 Prochloraz Chemical group 0.000 abstract description 14
- TVLSRXXIMLFWEO-UHFFFAOYSA-N prochloraz Chemical group C1=CN=CN1C(=O)N(CCC)CCOC1=C(Cl)C=C(Cl)C=C1Cl TVLSRXXIMLFWEO-UHFFFAOYSA-N 0.000 abstract description 13
- 239000000839 emulsion Substances 0.000 abstract description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract description 3
- 239000002253 acid Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 34
- 230000003449 preventive effect Effects 0.000 description 23
- 241000209094 Oryza Species 0.000 description 14
- 238000002360 preparation method Methods 0.000 description 11
- 238000012360 testing method Methods 0.000 description 11
- 241000219109 Citrullus Species 0.000 description 10
- 239000003814 drug Substances 0.000 description 9
- 230000002195 synergetic effect Effects 0.000 description 7
- 241000722363 Piper Species 0.000 description 6
- 241001672694 Citrus reticulata Species 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- OMOVVBIIQSXZSZ-UHFFFAOYSA-N [6-(4-acetyloxy-5,9a-dimethyl-2,7-dioxo-4,5a,6,9-tetrahydro-3h-pyrano[3,4-b]oxepin-5-yl)-5-formyloxy-3-(furan-3-yl)-3a-methyl-7-methylidene-1a,2,3,4,5,6-hexahydroindeno[1,7a-b]oxiren-4-yl] 2-hydroxy-3-methylpentanoate Chemical compound CC12C(OC(=O)C(O)C(C)CC)C(OC=O)C(C3(C)C(CC(=O)OC4(C)COC(=O)CC43)OC(C)=O)C(=C)C32OC3CC1C=1C=COC=1 OMOVVBIIQSXZSZ-UHFFFAOYSA-N 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 239000007921 spray Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 229910021380 Manganese Chloride Inorganic materials 0.000 description 3
- 208000036142 Viral infection Diseases 0.000 description 3
- 239000002131 composite material Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 230000005669 field effect Effects 0.000 description 3
- 229940099607 manganese chloride Drugs 0.000 description 3
- 239000011565 manganese chloride Substances 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 2
- 239000005995 Aluminium silicate Substances 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 235000012211 aluminium silicate Nutrition 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 229940077388 benzenesulfonate Drugs 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- LJSQFQKUNVCTIA-UHFFFAOYSA-N diethyl sulfide Chemical group CCSCC LJSQFQKUNVCTIA-UHFFFAOYSA-N 0.000 description 2
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 2
- 231100000053 low toxicity Toxicity 0.000 description 2
- OXOKTPUZOHPXSA-UHFFFAOYSA-L manganese(2+);n-propyl-n-[2-(2,4,6-trichlorophenoxy)ethyl]imidazole-1-carboxamide;dichloride Chemical compound Cl[Mn]Cl.C1=CN=CN1C(=O)N(CCC)CCOC1=C(Cl)C=C(Cl)C=C1Cl.C1=CN=CN1C(=O)N(CCC)CCOC1=C(Cl)C=C(Cl)C=C1Cl.C1=CN=CN1C(=O)N(CCC)CCOC1=C(Cl)C=C(Cl)C=C1Cl.C1=CN=CN1C(=O)N(CCC)CCOC1=C(Cl)C=C(Cl)C=C1Cl OXOKTPUZOHPXSA-UHFFFAOYSA-L 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 238000009331 sowing Methods 0.000 description 2
- WVUYNWCKWXAGLA-UHFFFAOYSA-N (ethoxydisulfanyl)oxyethane Chemical compound CCOSSOCC WVUYNWCKWXAGLA-UHFFFAOYSA-N 0.000 description 1
- DUIOKRXOKLLURE-UHFFFAOYSA-N 2-octylphenol Chemical compound CCCCCCCCC1=CC=CC=C1O DUIOKRXOKLLURE-UHFFFAOYSA-N 0.000 description 1
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 241000219112 Cucumis Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 235000009852 Cucurbita pepo Nutrition 0.000 description 1
- 240000001980 Cucurbita pepo Species 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- LVSNBJOSPVTNNS-UHFFFAOYSA-N [O].C1=CC=CC=C1.C(CCCCCCCC)C1=C(C=CC=C1)O Chemical compound [O].C1=CC=CC=C1.C(CCCCCCCC)C1=C(C=CC=C1)O LVSNBJOSPVTNNS-UHFFFAOYSA-N 0.000 description 1
- MIWVBVPUEOHJFV-UHFFFAOYSA-N [amino(azaniumylidene)methyl]-(diaminomethylidene)azanium;sulfate Chemical compound OS(O)(=O)=O.NC(N)=NC(N)=N MIWVBVPUEOHJFV-UHFFFAOYSA-N 0.000 description 1
- 239000003905 agrochemical Substances 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 150000004283 biguanides Chemical class 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229920005551 calcium lignosulfonate Polymers 0.000 description 1
- RYAGRZNBULDMBW-UHFFFAOYSA-L calcium;3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Ca+2].COC1=CC=CC(CC(CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O RYAGRZNBULDMBW-UHFFFAOYSA-L 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- OXBLHERUFWYNTN-UHFFFAOYSA-M copper(I) chloride Chemical compound [Cu]Cl OXBLHERUFWYNTN-UHFFFAOYSA-M 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 235000012055 fruits and vegetables Nutrition 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 230000035784 germination Effects 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 150000002696 manganese Chemical class 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- DOIRQSBPFJWKBE-UHFFFAOYSA-N phthalic acid di-n-butyl ester Natural products CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 description 1
- 230000008635 plant growth Effects 0.000 description 1
- 210000002706 plastid Anatomy 0.000 description 1
- 229920000151 polyglycol Polymers 0.000 description 1
- 239000010695 polyglycol Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 125000004646 sulfenyl group Chemical group S(*)* 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to plant protection field; relate to a kind of composition containing poly hexamethylene biguanide or its salt; said composition contains A, two kinds of active ingredients of B; A is poly hexamethylene biguanide or its salt; B is S-Ethyl ethylthio sulfonate or Prochloraz or Prochloraz salt; the ratio of quality and the number of copies of A, two kinds of compositions of B is 1:20-20:1, and cosmocil stearate is the one in cosmocil stearate acid, poly hexamethylene biguanide phosphate etc. Composition can be made into suspending agent, water dispersible granules, wettable powder, aqueous emulsion, microemulsion, aqua, the multiple diseases causing for preventing and treating fungi, bacterium and virus, is particularly useful for preventing and treating watermelon blight, citrus bacterial canker disease and anthracnose, bakanae disease of rice, pepper virus disease etc.
Description
Technical field
The invention belongs to plant protection field, be specifically related to a kind of bactericidal composition containing poly hexamethylene biguanide or its salt, combinationThing is mainly used in preventing and treating the disease of the various plants such as melon and fruit, vegetables, grain and cotton.
Background technology
Poly hexamethylene biguanide, molecular formula (C7H16N3Cl) n, is a kind of broad spectrum antimicrobicide efficiently, colorless and odorless, and consumption is low,Wide spectrum low toxicity, speed of action is fast, and foam volume is low, after using, forms for a long time antibacterial of one deck cation at article surface,Nontoxic. Poly hexamethylene biguanide can be adsorbed in rapidly bacterial cell surface as cationic germicide in agriculture field application, fastSpeed is attacked and is destroyed cell membrane, suppresses film lactones plastid synthetic, and cause thalline apoptosis, thereby reach best sterilization and disinfection effect,Germ, virus are pulled the grass up by its roots.
S-Ethyl ethylthio sulfonate (ethylicin), molecular formula C4H10O2S2, include the material effect of sulfenyl with thalline, thereby suppress thallineEubolism. S-Ethyl ethylthio sulfonate is Effictive nuisancelless wide spectrum bionic fungicide, has plant growth regulation concurrently, can promote rudiment, carryHigh germination rate, increasing output and improve quality, is the preferred raw materials of composite bactericide agricultural chemicals.
Prochloraz, molecular formula C15H16Cl3N3O2, be efficient, wide spectrum, low toxicity type bactericide, there is prevention protection treatment etc. multipleEffect, works by suppressing the biosynthesis of sterol, without systemic action, and the multiple disease causing for sac fungus and Fungi ImperfectiEvil preventive effect is splendid. Conventional use prevented and treated bakanae disease of rice, rice blast, anthracnose, the leaf spot etc. of gourd, fruit and vegetable.
For delaying the prevention effect of the drug-fast generation of germ and raising medicament, be necessary to carry out rational composition research. At present also, about the report of poly hexamethylene biguanide or its salt and S-Ethyl ethylthio sulfonate or Prochloraz composition research, inventor does not pass through Bactericidal compositeThe research of thing, has found some beyond thought effects.
Summary of the invention
The object of the present invention is to provide a kind of bactericidal composition containing poly hexamethylene biguanide or its salt with synergistic effect, thisInvention realizes by following measures.
The invention provides a kind of composition containing poly hexamethylene biguanide or its salt, it is characterized in that said composition contains A, BTwo kinds of active ingredients, A is poly hexamethylene biguanide or its salt, B is S-Ethyl ethylthio sulfonate or Prochloraz or Prochloraz salt, A, two kinds of one-tenth of BThe ratio of quality and the number of copies dividing is 1:20-20:1, and preferred, ratio of quality and the number of copies is 1:10-10:1.
In above-mentioned bactericidal composition, cosmocil stearate is hexamethylene, poly hexamethylene biguanide phosphoric acidSalt, poly hexamethylene biguanide nitrate, poly hexamethylene biguanide carbonate, poly hexamethylene biguanide sulfate, polyhexamethyleneOne in biguanides stearate, poly hexamethylene biguanide acetate.
In above-mentioned bactericidal composition, Prochloraz salt is the one in prochloraz-manganese chloride complex, prochloraz zinc salt, prochloraz nantokite etc.
In above-mentioned bactericidal composition, the quality sum of A and B accounts for the 1%-80% of composition gross mass.
Above-mentioned composition of the present invention can be made into suspending agent, water dispersible granules, wettable powder, aqueous emulsion, microemulsion, aqua etc.
The present invention also provides the application process containing the composition of poly hexamethylene biguanide or its salt, for the plant seed dressing to control,Spraying, filling root etc.
The application process of above-mentioned composition of the present invention, described plant be watermelon, oranges and tangerines, paddy rice, capsicum, apple, pears, grape,Lichee, cucumber, turfgrass, rape, wheat, flowers etc., preferred, described plant is watermelon, oranges and tangerines, paddy rice, capsicum.
The present invention also provides and has contained the composition of poly hexamethylene biguanide or its salt for the purposes of controlling plant diseases, suitable controlDisease be the multiple diseases that fungi, bacterium and virus cause, preferred, disease is watermelon blight, citrus bacterial canker disease and charcoalSubcutaneous ulcer disease, bakanae disease of rice, pepper virus disease etc.
Beneficial effect of the present invention is:
1, synergistic effect is obvious: composition shows good synergistic effect in certain ratio range, has improved the anti-of compositionSick effect.
2, reduce use cost: because of composite have improve preventive effect, reduced access times, reduced use cost;
3, delay the resistance to the action of a drug: the composition of two kinds of different mechanism of action is composite, pathogen is difficult for developing immunity to drugs, and delays pathogenTo the drug-fast generation of medicament.
Detailed description of the invention
Following examples are to further illustrate of the present invention, but the present invention is not limited to ratio, preparation class in present embodimentType and purposes.
Embodiment 112% poly hexamethylene biguanide S-Ethyl ethylthio sulfonate suspending agent
Poly hexamethylene biguanide 6g, S-Ethyl ethylthio sulfonate 6g, sodium lignin sulfonate 5g, Magnesiumaluminumsilicate 2g, glycerine 5g are fully mixed,The 25g that adds water fully grinds, and water complements to 100g, obtains 12% poly hexamethylene biguanide S-Ethyl ethylthio sulfonate suspending agent.
Embodiment 214% hexamethylene prochloraz-manganese chloride complex suspending agent
By hexamethylene 12g, prochloraz-manganese chloride complex 2g, sodium lignin sulfonate 5g, Magnesiumaluminumsilicate 2g, glycerine5g fully mixes, and the 25g that adds water fully grinds, and water complements to 100g, obtains 14% hexamethylene ProchlorazThe agent of manganese salt suspension.
Embodiment 310% poly hexamethylene biguanide prochloraz zinc salt water dispersible granules
By poly hexamethylene biguanide 1g, prochloraz zinc salt 9g, calcium lignosulfonate 5g, octyl phenol polyglycol ether 2g, IUncle glue 5g fully mixes, and white carbon complements to 100g to be mixed, and mixture is carried out to granulation after ultra-fine grinding, dry, screening,Both made 10% poly hexamethylene biguanide prochloraz zinc salt water dispersible granules.
Embodiment 410% hexamethylene S-Ethyl ethylthio sulfonate wettable powder
Hexamethylene 9g, S-Ethyl ethylthio sulfonate 1g, sodium alkyl benzene sulfonate 2g, kaolin are supplied to 100g and mix, willEach component is dry, cooling, levigate, has both been mixed with 10% hexamethylene S-Ethyl ethylthio sulfonate wettable powder.
Embodiment 510% poly hexamethylene biguanide phosphate S-Ethyl ethylthio sulfonate wettable powder
Poly hexamethylene biguanide phosphate 1g, S-Ethyl ethylthio sulfonate 9g, sodium alkyl benzene sulfonate 2g, kaolin are supplied to 100g and mix, willEach component is dry, cooling, levigate, has both been mixed with 10% poly hexamethylene biguanide phosphate S-Ethyl ethylthio sulfonate wettable powder.
Embodiment 64% poly hexamethylene biguanide prochloraz aqueous emulsion
Poly hexamethylene biguanide phosphate 2g, Prochloraz 2g, ethanol 4g, nonyl phenol benzene oxygen vinethene 3g, 2,6-di-t-butyl-4-methylphenol 2g, ethylene glycol 3g, polyvinyl alcohol 1g, Sodium Benzoate 1g, silicone defoaming agent 0.5g mix, and water is suppliedTo 100g, both made 4% poly hexamethylene biguanide prochloraz aqueous emulsion.
The effect of embodiment 7 compositions to watermelon blight
According to scheme, preparation built agent and single dose, aqua preparation, and carry out active preliminary experiment. According to trial test, preparation is joinedMake the concentration needing. Before selecting, stubble watermelon blight morbidity field, arranges field evenly. The preparation of the different medicaments of medication is equalEven seed dressing (concentration is in effective milligram quantities of every kilogram of seed with medicament), sowing, Routine Management. Investigation west in the time of disease onsetMelon plant diseases situation. Use Abbot formula, convert percentage to preventive effect.
In theoretical effect, x is the effect of the substance A of concentration while being a, and y is the effect of the substance B of concentration while being b, relatively reasonOpinion effect and actual effect, evaluate the synergy of composition, while being greater than theoretical preventive effect taking actual preventive effect as synergistic effect. CombinationThing the results are shown in Table 1 to watermelon disease.
The effect of table 1 composition to watermelon blight
Test by the composition containing poly hexamethylene biguanide or its salt to watermelon blight, as seen from Table 1, joins at compositionWhen ratio is 1:2.5-4:1, composition, poly hexamethylene biguanide or its salt and the miaow of poly hexamethylene biguanide or its salt and S-Ethyl ethylthio sulfonateThe composition of fresh amine or its salt to the actual preventive effect of watermelon blight all higher than composition theoretical preventive effect. Obviously, containing poly-The composition of hexamethylene biguan-ide or its salt is synergy to watermelon blight.
Embodiment 8 compositions are to citrus disease field test
According to scheme, preparation built agent and single dose, and carry out active preliminary experiment. According to determination of activity trial test, preparation is preparedThe concentration that becomes to need. Before test, community is set, lists, and establish corresponding single dose and blank, adopt manual sprayer routineConventional spray. After the 1st spraying, 7-10d sprays 1 time again, and after the 2nd dispenser, 10-14d investigates the c itrus canker of listing and processingDisease and anthracnose incidence. The list incidence of disease of blade different diseases of visually rank, uses Abbot formula, and percentage is turnedChange preventive effect into.
In theoretical effect, x is the effect of the substance A of concentration while being a, and y is the effect of the substance B of concentration while being b, relatively reasonOpinion effect and actual effect, evaluate the synergy of composition, while being greater than theoretical preventive effect taking actual preventive effect as synergistic effect. CombinationThing the results are shown in Table 2 to the prevention effect of mandarin orange disease.
Table 2 composition is to citrus disease field effect
Test by the composition containing poly hexamethylene biguanide or its salt to citrus disease, as seen from Table 2, in composition proportioningDuring for 1:5-5:1, the composition of the composition of poly hexamethylene biguanide and S-Ethyl ethylthio sulfonate, poly hexamethylene biguanide and Prochloraz is to mandarin orangeThe actual preventive effect of tangerine canker and anthracnose all higher than composition theoretical preventive effect. Obviously, containing poly hexamethylene biguanide orThe composition of its salt is synergy to citrus bacterial canker disease and anthracnose.
The effect of embodiment 9 compositions to rice disease
According to scheme, preparation built agent and single dose preparation, and carry out active preliminary experiment. According to determination of activity trial test, by preparationBe mixed with the concentration needing. Select the rice field of once falling ill, (concentration is with every kilogram of seed with medicament to rice paddy seed seed dressing for medicamentEffectively milligram quantities meter), sowing, seedling. In the time that blank bakanae disease of rice occurs, institute an inquiry, 5 samplings are pressed in every processing,Every 50 strains, measure the percentage that infect on plant blade face. Use Abbot formula, convert percentage to preventive effect.
In theoretical effect, x is the effect of the substance A of concentration while being a, and y is the effect of the substance B of concentration while being b, relatively reasonOpinion effect and actual effect, evaluate the synergy of composition, while being greater than theoretical preventive effect taking actual preventive effect as synergistic effect. CombinationThing to the preventive effect of bakanae disease of rice in table 3.
Table 3 composition is to bakanae disease of rice field effect
Test by the composition containing poly hexamethylene biguanide or its salt to bakanae disease of rice, as seen from Table 3, joins at compositionWhen ratio is 1:4 and 1:1, composition, poly hexamethylene biguanide or its salt and the miaow of poly hexamethylene biguanide or its salt and S-Ethyl ethylthio sulfonateThe composition of fresh amine to the actual preventive effect of bakanae disease of rice all higher than composition theoretical preventive effect. Obviously, containing poly-six methylenesThe composition of base biguanides or its salt is synergy to bakanae disease of rice.
The effect of embodiment 10 compositions to pepper virus disease
According to scheme, preparation built agent and single dose preparation, and carry out active preliminary experiment. According to determination of activity trial test, by preparationBe mixed with the concentration needing. Before test, establish corresponding single dose and blank in capsicum field, adopt the conventional conventional spray of manual sprayer,Every medicament sprays 50 strains. 7-10d dispenser 1 time again after the 1st dispenser. 10-20d after the 2nd dispenser, investigates the capsicum of listing and plantsStrain virus state of an illness condition. Use Abbot formula, convert percentage to preventive effect.
In theoretical effect, x is the effect of the substance A of concentration while being a, and y is the effect of the substance B of concentration while being b, relatively reasonOpinion effect and actual effect, evaluate the synergy of composition, while being greater than theoretical preventive effect taking actual preventive effect as synergistic effect. CombinationThing to the effect of pepper plant virosis in table 4.
Table 4 composition is to pepper virus disease field effect
Test by the composition containing poly hexamethylene biguanide or its salt to pepper virus disease, as seen from Table 4, joins at compositionWhen ratio is 1:3, the composition of composition, poly hexamethylene biguanide and the Prochloraz of poly hexamethylene biguanide and S-Ethyl ethylthio sulfonate is to capsicumThe actual preventive effect of virosis all higher than composition theoretical preventive effect. Obviously the composition that, contains poly hexamethylene biguanide is to pepperyGreen pepper virosis is synergy.
Claims (9)
1. containing the composition of poly hexamethylene biguanide or its salt, it is characterized in that said composition contains A, two kinds of active ingredients of B, A isPoly hexamethylene biguanide or its salt, B is S-Ethyl ethylthio sulfonate, the ratio of quality and the number of copies of A, two kinds of compositions of B is 1:9-9:1.
2. according to the composition of claim 1, it is characterized in that cosmocil stearate is hexamethylene, poly-sixMethylene biguanides phosphate, poly hexamethylene biguanide nitrate, poly hexamethylene biguanide carbonate, poly hexamethylene biguanide sulfuric acidOne in salt, poly hexamethylene biguanide stearate, poly hexamethylene biguanide acetate.
3. according to the composition of claim 1, it is characterized in that the quality sum of A, two kinds of compositions of B accounts for the 1%-80% of composition gross mass.
4. according to the composition of claim 3, it is characterized in that composition makes suspending agent, water dispersible granules, wettable powder, waterEmulsion, microemulsion, aqua.
5. the application process of the composition of claim 3, is characterized in that composition is for the plant seed dressing to control, spraying, filling root.
6. according to the method for claim 5, it is characterized in that plant be watermelon, oranges and tangerines, paddy rice, capsicum, apple, pears, grape,Lichee, cucumber, turfgrass, rape, wheat, flowers.
7. according to the method for claim 6, described plant is watermelon, oranges and tangerines, paddy rice, capsicum.
8. the composition of claim 4 is for preventing and treating the purposes of fungi, bacterium and the viral multiple diseases causing.
9. purposes according to Claim 8, is characterized in that disease is watermelon blight, citrus bacterial canker disease and anthracnose, rice bakanae diseaseSick, pepper virus disease.
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| TWI626229B (en) * | 2016-09-22 | 2018-06-11 | 中國石油化學工業開發股份有限公司 | Synthesis of biguanid phosphate and bactericide |
| CN107372568A (en) * | 2017-07-18 | 2017-11-24 | 广东中迅农科股份有限公司 | A kind of bactericidal composition |
| CN112471166A (en) * | 2021-01-14 | 2021-03-12 | 石磊 | Bactericidal composition containing polyhexamethylene biguanide and nano silver and application thereof |
| CN114097815A (en) * | 2021-11-25 | 2022-03-01 | 兰州大学 | Application of medical compound with amidine skeleton in resisting plant pathogenic bacteria |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102461653A (en) * | 2010-11-14 | 2012-05-23 | 中国科学院华南植物园 | Application of polyhexamethylene guanidine in citrus sour rot prevention and treatment, and citrus antistaling agent containing polyhexamethylene guanidine |
| CN102461652A (en) * | 2010-11-14 | 2012-05-23 | 中国科学院华南植物园 | Application of polyhaxemethylenguanidine hydrochloride on preventing and controlling orange sour rot and preservative for citrus |
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| WO2002069715A2 (en) * | 2001-03-06 | 2002-09-12 | Bayer Cropscience Ag | Seed dressing agent |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102461653A (en) * | 2010-11-14 | 2012-05-23 | 中国科学院华南植物园 | Application of polyhexamethylene guanidine in citrus sour rot prevention and treatment, and citrus antistaling agent containing polyhexamethylene guanidine |
| CN102461652A (en) * | 2010-11-14 | 2012-05-23 | 中国科学院华南植物园 | Application of polyhaxemethylenguanidine hydrochloride on preventing and controlling orange sour rot and preservative for citrus |
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| 盐酸聚六亚甲基双胍消毒剂杀菌性能的试验观察;张晓玲 等;《中国消毒学杂志》;20111231;第28卷(第2期);第139-140页 * |
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