CN104180616A - Drying method for lamiophlomis rotata - Google Patents
Drying method for lamiophlomis rotata Download PDFInfo
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- CN104180616A CN104180616A CN201410418720.XA CN201410418720A CN104180616A CN 104180616 A CN104180616 A CN 104180616A CN 201410418720 A CN201410418720 A CN 201410418720A CN 104180616 A CN104180616 A CN 104180616A
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Abstract
The invention relates to a drying method for lamiophlomis rotata. The prepared lamiophlomis rotata which is frozen in a drying process has high total saponin content and high total flavonoid content.
Description
Invention field
The present invention relates to medicine method for making, particularly a kind of drying means of lamiophlomis rotata, belongs to medical technical field.
Background technology
Lamiophlomis rotata is the dry aerial parts of Labiatae lamiophlomis rotata platymiscium lamiophlomis rotata.It has promoting blood circulation and hemostasis, effect of wind-expelling pain-stopping, and for traumatic injury, traumatism and bleeding, arthralgia due to wind-dampness, grasserie etc.Mainly contain the active ingredients such as flavonoids, iridoids, saponins.
The lamiophlomis rotata ground such as being grown in Gansu, Qinghai, Chuan Xi plateau, Tibet that mainly distributes, collecting season is annual 8, September.Because lamiophlomis rotata growth area mostly is economically underdeveloped area, the not unified processing conditions of gathering, the various places personnel that gather mostly also are local resident, so cause Post-harvest processing method to differ, quality fluctuation is larger.Adopt which kind of method dry better, at present, not yet report.
The inventor compares research to the main total saponin(e of active ingredient and general flavone in the lamiophlomis rotata of different dry drying method, has proposed a kind of new drying means.
Summary of the invention
The object of this invention is to provide a kind of drying means of lamiophlomis rotata, the lamiophlomis rotata that the method is dry, the main total saponin(e of active ingredient, general flavone and alcohol extract content are far above other drying means.
A drying means for lamiophlomis rotata is that dry run is through freezing.
The drying means of a kind of lamiophlomis rotata of the present invention, dry run through freezing be freezing, dry or freezing, bank up, be dried or bank up, freezing, dry.
The drying means of a kind of lamiophlomis rotata of the present invention, freezing is to be refrigerated to freeze.
The drying means of a kind of lamiophlomis rotata of the present invention, banking up is the 2-5 days that banks up.
The drying means of a kind of lamiophlomis rotata of the present invention, dry is dry or dry or dry after freezing.
So far completed the present invention, the lamiophlomis rotata of preparing by lamiophlomis rotata drying means of the present invention, the main total saponin(e of active ingredient and general flavone content are far above higher than other drying means, and then known for traumatic injury, traumatism and bleeding, arthralgia due to wind-dampness, the disease clinical efficacies such as grasserie are better.
Further illustrate usefulness of the present invention below by test example, test example is intended to further illustrate usefulness of the present invention, but not limitation of the present invention.
To, with a collection of fresh lamiophlomis rotata, process by the following method.
1) dry: be put in shady and cool ventilation place, spread out and dry;
2) dry: 80 DEG C of following oven dry;
3) freezing oven dry: be refrigerated to-5 DEG C to freezing, take out, 80 DEG C of following oven dry;
4) the freezing oven dry of banking up: be refrigerated to-5 DEG C to freezing, take out, bank up 2 days, 80 DEG C of following oven dry;
5) the freezing oven dry of banking up: bank up 2 days, be refrigerated to-5 DEG C to freezing, take out, 80 DEG C of following oven dry;
6) freeze-drying lamiophlomis rotata: fresh lamiophlomis rotata, be refrigerated to below-20 DEG C, be evacuated to below drying chamber pressure 45Pa, heating sublimation, the temperature of distillation should be controlled at below 40 DEG C, and the temperature of resolution phase is controlled at below 45 DEG C, to dry.
7) fresh lamiophlomis rotata: without any processing.
One, n-butanol extracts the content comparison of total saponin(e
Each 0. 5 g of sample, accurately weighed respectively, puts in 150mL conical flask, and precision adds people's n-butanol 100mL, jam-pack, and cold soaking 1h, filters rapidly, and precision measures subsequent filtrate 20mL, puts in the evaporating dish that is dried to constant weight.After water bath method, in 150 DEG C of dry 3h, put cooling 30min in drier, accurately weighed, to obtain final product.The results are shown in Table 1.
Table 1 n-butanol extracts the content comparison (%, n=3) of total saponin(e
▲ fresh lamiophlomis rotata is in dry product.
Found out by table 1, lamiophlomis rotata " freezing oven dry ", " freezing heap postpone is dry " and " the freezing oven dry of banking up " total saponin content are apparently higher than " drying ", " oven dry ", " freeze-drying " and " fresh goods ".Total saponin(e is and the closely-related important activity composition of lamiophlomis rotata analgesia effect that lamiophlomis rotata clinical efficacy prepared by known the inventive method is good.
Two, the content side of general flavone compares surely
1, instrument and reagent
Instrument: the visible spectrophotometer of ultraviolet one; Electronic balance; Control substance of Rutin.
2, detect determining of wavelength
After the colour developing of control substance of Rutin aluminum nitrate, have absorption maximum at 500-510nm wavelength place, in conjunction with document, test selects 500nm for detecting wavelength.
3, the preparation of reference substance solution
Precision takes the control substance of Rutin 10mg to constant weight at 120 DEG C of drying under reduced pressure, puts in 50mL measuring bottle, adds 70% ethanol 35mL, puts low-grade fever in water-bath and makes to dissolve, and lets cool, and adds 70% ethanol to scale, shakes up, and obtains (in every mL, containing anhydrous rutin 0.2mg).
4, test sample preparation and assay
Get the each 0.1g of lamiophlomis rotata medicinal material, accurately weighed, put in l00mL volumetric flask, add 70% ethanol 70mL, after jolting, add ethanol to scale, place lh, filter rapidly with dry filter, precision measures subsequent filtrate 6mL, put in 25mL volumetric flask, add 5% sodium nitrite solution 1mL, mix, place 6min; Add 10% aluminum nitrate solution lmL, shake up, place 6min; Hydro-oxidation sodium test solution 10mL, then add water to scale, shake up, place 15min.Measure trap according to AAS at 500nm wavelength place, calculate, to obtain final product.The results are shown in Table 2.
The content comparison (%, n=3) of table 2 general flavone
▲ fresh lamiophlomis rotata is in dry product.
Found out by table 2, after lamiophlomis rotata distinct methods is dry, the content of general flavone all increases to some extent, and freezing banking up dried the > freezing oven dry of freezing the ovens dry > > freeze-drying > that banks up and dried > oven dry > fresh goods.General flavone is one of active component important with lamiophlomis rotata, uses as seen freeze drying technology can prepare highly active lamiophlomis rotata medicine materical crude slice.
Three, the content side of ethanol soluble extractives compares surely
Measure according to the hot dipping under Chinese pharmacopoeia ethanol soluble extractives determination method (annex X A) item, make solvent with 70% ethanol, the results are shown in Table 3.
The content comparison (%) of table 3 ethanol soluble extractives
▲ fresh lamiophlomis rotata is in dry product.
Detailed description of the invention
embodiment 1
Get fresh lamiophlomis rotata, be refrigerated to-5 DEG C to freezing, dry in the shade.
embodiment 2
Get fresh lamiophlomis rotata, be refrigerated to-10 DEG C to freezing, dry.
embodiment 3
Get fresh lamiophlomis rotata, bank up 2 days, be refrigerated to below-15 DEG C, dry.
embodiment 4
Get fresh lamiophlomis rotata, bank up 5 days, be refrigerated to-20 DEG C to freezing, 60 DEG C of oven dry.
embodiment 5
Get fresh lamiophlomis rotata, bank up 4 days, be refrigerated to-5 DEG C to freezing, take out,, dry.
embodiment 6
Get fresh lamiophlomis rotata, be refrigerated to-15 DEG C, take out, bank up 3 days, dry.
embodiment 7
Get fresh lamiophlomis rotata, be refrigerated to-30 DEG C, take out, bank up 2 days, 80 DEG C of oven dry.
embodiment 8
Get fresh lamiophlomis rotata, be refrigerated to-32 DEG C, take out, bank up 3 days, 60 DEG C of oven dry.
Claims (3)
1. a drying means for lamiophlomis rotata, is characterized in that: dry run is through freezing.
2. according to the drying means of a kind of lamiophlomis rotata of claim 1, it is characterized in that: dry run through freezing be freezing, dry or freezing, bank up, be dried or bank up, freezing, dry.
3. according to the drying means of a kind of lamiophlomis rotata of claim 1 or claim 2, wherein, freezing is to be refrigerated to freeze; Banking up is the 2-5 days that banks up; Dry is dry or dry or dry after freezing.
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| CN201410418720.XA CN104180616A (en) | 2014-08-25 | 2014-08-25 | Drying method for lamiophlomis rotata |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104142048A (en) * | 2014-08-25 | 2014-11-12 | 济南康众医药科技开发有限公司 | Lamiophlomis herba drying method |
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2014
- 2014-08-25 CN CN201410418720.XA patent/CN104180616A/en active Pending
Patent Citations (5)
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| JPH09182268A (en) * | 1995-12-26 | 1997-07-11 | Hitachi Cable Ltd | Cable terminal box of apparatus-directly-coupled type |
| CN103055022A (en) * | 2013-01-10 | 2013-04-24 | 济南康众医药科技开发有限公司 | Method for processing rehmannia and application for rehmannia in preparation for medicine |
| CN103948642A (en) * | 2014-05-15 | 2014-07-30 | 济南康众医药科技开发有限公司 | Application of refrigeration technique in phellinus igniarius drying |
| CN103948638A (en) * | 2014-05-15 | 2014-07-30 | 济南康众医药科技开发有限公司 | Drying method of medical fungi |
| CN103977041A (en) * | 2014-05-15 | 2014-08-13 | 济南康众医药科技开发有限公司 | Drying method of ganoderma applanatum pat |
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| 刘红亮等: "中药材"发汗"对药材质量的影响", 《中国实验方剂学杂志》 * |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104142048A (en) * | 2014-08-25 | 2014-11-12 | 济南康众医药科技开发有限公司 | Lamiophlomis herba drying method |
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Application publication date: 20141203 |