CN104177641B - A kind of method for preparing lubricating coating in medical polyvinyl material surface - Google Patents
A kind of method for preparing lubricating coating in medical polyvinyl material surface Download PDFInfo
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- CN104177641B CN104177641B CN201410394460.7A CN201410394460A CN104177641B CN 104177641 B CN104177641 B CN 104177641B CN 201410394460 A CN201410394460 A CN 201410394460A CN 104177641 B CN104177641 B CN 104177641B
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Abstract
The present invention discloses a kind of method for preparing lubricating coating in medical polyvinyl material surface, including：Step one, in clean medical PVC material surface coating medical PU coatings, dry, clean, being dried；Step 2, the medical PVC material of step one is carried out into pretreatment, including ozone, ion sputtering or ultraviolet light；Step 3, the medical PVC material of step 2 is added in reaction solution grafting under anaerobic reaction, reaction temperature be 30 DEG C～80 DEG C, the response time be 1h～36h；Reaction solution includes reaction dissolvent, lubrication layer material and reaction additives；Step 4, by grafting reacted product washing, be dried to obtain the product.This method greatly improves the firmness and lubricity of medical PVC surface lubrication layer, and simple and easy to control, improves make efficiency, is easy to promote and industrialized production.
Description
Technical field
The present invention relates to the technical field of medical polymer functionalizing material surface, and in particular to one kind is in medical polychlorostyrene second
The method that alkene material surface prepares lubricating coating.
Background technology
Used as the existing history for many years of medical material, which has resistance to chemical corrosion to polrvinyl chloride (PVC), to oxidant, also
Former agent and strong acid have very strong resistance, and wear-resisting, it is easy to produce, using safe, with low cost.This kind of material with it is quiet
There is the good compatibility between arteries and veins injection and blood, thus be widely used, such as various flexible pipe for medical purpose, blood storage are filled
Put, adnexa of dialysing, surgical glove, medical condition and artificial organ etc..
Shown according to report, China is risen to from medical catheter import volume between 2006 to 2010 from 1.69 hundred million dollars
4.41 hundred million dollars, export amount rises to 6.22 hundred million dollars from 3.34 hundred million dollars, in view of this in recent years the equal amplification of import-export volume compared with
Greatly, up to 10.63 hundred million dollars.And favourable trade balance fluctuates between 1 hundred million to 3 hundred million dollar.Medical catheter has become the second largest doctor of China
Plastic outlet product is used, disposable syringe is only second to.But Development Level of the domestic manufacturing enterprise of China to this kind of conduit
Still await improving, so the medical institutions of China are main to the application of these products or based on import.In a word, it is medical
Conduit market still possesses huge development potentiality, medical catheter manufacturing enterprise of China should with reference to the actual features of itself,
Innovation Input is increased, is striven for introducing Professional Talent Team and is used for reference the management mode of some foreign outstandings, make great efforts research and development new
, the product that effect is good.
Medical PVC granulating technique made rapid progress in recent years, and as disposable product, for economic performance, PVC is still
It is so most economical selection.But as material is too hard, tissue can be substantially damaged when in use, and in insertion human body
When the friction that produces can bring huge pain to patient, or even can also adsorb a large amount of antibacterials and cause inflammatory reaction.
Good medical catheter material should possess following condition：1. have appropriate flexibility, excellent lubricity and
Hydrophilic, reduces the stimulation and damage to vascular tissue；2. possess chemical stability, do not produce with body fluid mutual bad anti-
Should；3. there is good biocompatibility, ooze out without nuisance, the phenomenon of haemolysis, blood coagulation poisoning or allergy of having a fever will not be caused.
But as these materials are hydrophobic in itself, so the lubricity on surface is not also much up to during using medical catheter
To requiring, therefore by material surface modifying improving lubricity.
Medical PVC catheter surface method of modifying can substantially be divided into two big class：Physical modification and chemical modification.Physical modification bag
Surface physics cladding process and mechanically modifying etc. are included, this kind of method of modifying only occurs physical reactions.Chemical modification method mainly has low
Isothermal plasma facture, light-initiated grafting and chemical grafting treated method etc..Although the method cost of physics coating is relatively low,
The method is weaker due to adhesive force, so coating easily comes off, this method is gradually eliminated.Patent CN202909253U will contract
Aldehyde polymer, hydrophilic polymer are sufficiently stirred for after being mixed with organic solvent with citric acid ester plasticiser, until completely dissolved
Form homogeneous hydrophilic coating solution.Medical catheter is immersed in hydrophilic coating solution or using the method for spraying, with parent
The conduit of water coating is dried process Jing after drying to which, so as to form stable coating on the surface of medical catheter.Patent
CN101711894B forms polyvinylpyrrolidone in polyurethane (PU) catheter surface by ultraviolet light irradiation graft polymerization reaction
Ketone (PVP) modified layer (i.e. PU-g-PVP structures), and then by PU-g-PVP and the complex reaction of iodine (I), prepare PU-g-PVP-
I structures.PVP-I (povidone iodine) is connected with chemical bond with PU catheter surfaces, it is possible to increase its hydrophilic and lubricity.And patent
CN1537643A discloses a kind of medical catheter surface that is coated on and reduces the medical lubricating fluid of frictional resistance.It is (fine which is divided into 1#
The plain esters of dimension, adhesive polymer, plasticizer) and two kinds of 2# (hydrophilic polymer, cellulose esters), which is successively coated in medical
78% coefficient of friction can be reduced on conduit.Existing chemical modification still there is a problem that it is certain, such as：Modification procedure is numerous
The trivial, modifying agent that uses is expensive, is unsuitable for that routine use, use time be short, material surface modified coating is unstable：It is easily de-
Fall or the holding time is not long etc..
The content of the invention
It is an object of the present invention to provide a kind of method for preparing lubricating coating in medical polyvinyl material surface, the method
The firmness and lubricity of surface of medical polyvinyl chloride lubricating layer are substantially increased, and process is simple and easy to control, improves
Make efficiency, is easy to promote and industrialized production.
The present invention is employed the following technical solutions：
A kind of method for preparing lubricating coating in medical polyvinyl material surface, comprises the steps：
Step one, by medical polyvinyl material clean, drying, afterwards in surface-coated medical polyurethane coating, dry,
Clean, be dried；
Step 2, the medical polyvinyl material for obtaining step one carry out pretreatment, the pretreatment include ozone, from
Son sputtering or ultraviolet light；
Step 3, the medical polyvinyl material for obtaining step 2 are added in reaction solution grafting under anaerobic
Reaction, wherein, reaction temperature is 30 DEG C～80 DEG C, and the response time is 1h～36h；The reaction solution includes reaction dissolvent, profit
Smooth material and reaction additives, lubricating layer quality of materials percentage ratio are 1%～20%, and reaction additives mass percent is 0
～5%；
Step 4, by grafting reacted medical polyvinyl material washing, be dried to obtain the product.
Also comprise the steps between step one and step 2：The medical polyvinyl material that step one is obtained carries out pre-
Process, the pretreatment includes ozone, ion sputtering or ultraviolet light；Afterwards medical polyvinyl material is added to
In 0.5wt%～25wt% acrylic acid solutions, 2～12h is reacted at 30～80 DEG C；After reaction terminates, clean, be dried.
Be applied to described in step one physics coating, medical polyurethane concentration be 1wt%～30wt%, 10～40 DEG C, it is wet
Spend to be coated under conditions of 20%～70%, coating thickness is 10nm～1000nm.The medical polyurethane is medical poly-
Ester system polyurethane, medical polyethers system polyurethane, medical fat adoption urethane or medical aromatic urethane.
The ozone is processed：Ozone concentration be 1～50mg/L, ozone flow be 100～600L/h, treatment temperature be 0～
70 DEG C, process time is 10～180min；Ion sputtering is processed：Under oxygen atmosphere, ion sputtering power is 10～300W, is located
The reason time is 1～60min；Ultraviolet light process：Ultraviolet ray intensity is 50 μ W/cm2～50mW/cm2, process time is 5min
～8h.
Reaction dissolvent described in step 3 includes water, methanol, ethanol, acetone, butanone, hexamethylene, toluene, ethyl acetate, heptan
One or more in alkane, chloroform, dichloromethane, tetrahydrofuran, N-N dimethylformamides.The lubrication layer material includes third
Acrylamide, N, N- DMAAs, N- vinylpyrrolidones, polyvinylpyrrolidone, polyethylene glycol oxide, methacrylic acid
One or more in hydroxyl ethyl ester, 2-(Acryloyloxy)ethanol, polyvinyl alcohol.The reaction additives include Oleum Ricini, benzophenone,
Persulfate, nitric acid, ammonium ceric nitrate, benzoyl peroxide, ethylene glycol, Ethylene glycol adipate, triethylene glycol diacrylate
One or more in ester.
Beneficial effects of the present invention：
1st, the lubricant coating preparation method that the present invention is provided key point first is the medical polychlorostyrene for coating polyurethane coating
The activation on vinyl material surface.Activate with the method such as ozone or ion sputtering or ultra-vioket radiation and cause material list mask
There are suitable roughness and reactivity position so that in hgher efficiency in grafting procedures.Secondly because surface lubrication layer is transferred
Connect, the matsurface of script can be capped, have no effect on the convenience degree and level of comfort for using.Meanwhile, in order to lubricating layer it is more preferable
Grafting, can activated coating polyurethane one acrylic acid transition zone of material surface grafting so that the lubrication of grafting
Layer is more stable, and lubricity is higher.
2nd, the invention provides a stable method of modifying, improves manufacture method and proportioning raw materials, substantially increase doctor
With the firmness and lubricity of pvc material surface lubrication layer, not only apply the lubrication of medical polyvinyl material surface
Layer more firmly, using more longlasting, and greatly reduces coefficient of friction, reduces the injury to bodily tissue, also can be more preferable
Ground is compatible with human body, it is to avoid produce foreign body, reduces sense of discomfort and foreign body sensation, and is easy to preserve, and makes doctor and patient using more
Plus Energy and comfort.
3rd, manufacture method of the invention is simple and easy to control, and required condition is not high, is liquid-solid reaction, and key needs control
Condition is temperature and time, simple and easy to control, improves make efficiency, is easy to promote and realizes in industrial big production.
Specific embodiment
The present invention is done with reference to embodiment and further explained.Following embodiments do not limit this in any form
It is bright, all technical schemes obtained by the way of equivalent or equivalent transformation, among being in protection scope of the present invention.
A kind of method for preparing lubricating coating in medical polyvinyl material surface, comprises the steps：
Step one, medical polyvinyl material is used distilled water and ethanol purge, vacuum drying respectively, afterwards in surface thing
Reason coating medical polyurethane coating, dries, cleans, being dried；Wherein, described to be applied to physics coating, medical polyurethane concentration is
1wt%～30wt%, 10～40 DEG C, humidity be 20%～70% under conditions of be coated, coating thickness be 10nm～
1000nm；The medical polyurethane is medical Polyester polyurethane, medical polyethers system polyurethane, medical fat adoption urethane or doctor
Use aromatic urethane.
Step 2, the medical polyvinyl material for obtaining step one carry out pretreatment, so that its surface has suitably
Roughness and reactivity are reacted come the grafting for carrying out lower step；The pretreatment includes ozone, ion sputtering or ultraviolet light；
Ozone process：Ozone concentration is 1～50mg/L, and ozone flow is 100～600L/h, and treatment temperature is 0～70 DEG C, process time
For 10～180min；Ion sputtering is processed：Under oxygen atmosphere, ion sputtering power be 10～300W, process time be 1～
60min；Ultraviolet light process：Ultraviolet ray intensity is 50 μ W/cm2～50mW/cm2, process time is 5min～8h.Surface is pre-
The intensity of process, from the point of view of the reaction active site on surface.
Step 3, the medical polyvinyl material for obtaining step 2 are added in reaction solution grafting under anaerobic
Reaction, wherein, reaction temperature is 30 DEG C～80 DEG C, and the response time is 1h～36h；The reaction solution includes reaction dissolvent, profit
Smooth material and reaction additives, lubricating layer quality of materials percentage ratio are 1%～20%, and reaction additives mass percent is 0
～5%；Reaction dissolvent includes water, methanol, ethanol, acetone, butanone, hexamethylene, toluene, ethyl acetate, heptane, chloroform, dichloro
One or more in methane, tetrahydrofuran, N-N dimethylformamides.Lubrication layer material includes acrylamide, N, N- dimethyl
Acrylamide, N- vinylpyrrolidones, polyvinylpyrrolidone, polyethylene glycol oxide, hydroxyethyl methylacrylate, acrylic acid hydroxyl second
One or more in ester, polyvinyl alcohol.Reaction additives include Oleum Ricini, benzophenone, persulfate, nitric acid, cerous nitrate
One or more in ammonium, benzoyl peroxide, ethylene glycol, Ethylene glycol adipate, triethylene glycol diacrylate.
Step 4, by grafting reacted medical polyvinyl material under magnetic stirring condition, temperature is 30～60 DEG C
12～24h of washing in distilled water, middle replacing distilled water more than 10 times, then 15～60min of EtOH Sonicate cleaning, is vacuum dried
Obtain the product.
In order that lubricating layer grafting efficiency is higher, can also comprise the steps between step one and step 2：By step
The one medical polyvinyl material for obtaining carries out pretreatment, and the pretreatment includes ozone, ion sputtering or ultraviolet light；It
Afterwards medical polyvinyl material is added in 0.5wt%～25wt% acrylic acid solutions, 2～12h is reacted at 30～80 DEG C；
After reaction terminates, clean, be dried.
Under humidified condition, contact angle is at 0 ° for the medical polyvinyl material surface of the lubricant coating that the present invention is prepared
～35 °, the coefficient of kinetic friction is 0.01～0.15.
Embodiment 1
Take the clean medical polyvinyl conduits of 10g, at 30 DEG C, coating medical polyurethane coating under 45% damp condition
(medical polyurethane concentration is 15wt%, and coating thickness is 150nm), dries, and cleans, vacuum drying.In 40 DEG C, 15mg/L,
30min is activated in the ozone of 400L/h.The analytically pure acrylamides of 3g, 97g distillations are separately added in the there-necked flask of 200ml
Water and 0.5g potassium peroxydisulfates.Medical polyvinyl conduit after activation is added in there-necked flask, under 50 DEG C of oil baths, nitrogen
Protective condition, magnetic agitation 5h.After reaction, medical polyvinyl conduit is cleaned into 12h in 45 DEG C of distilled water, centre is at least
Replacing distilled water 10 times, is then cleaned by ultrasonic 30min in ethanol, and 60 DEG C are dried under vacuum to constant weight.
In the case of the Catheter wetting for preparing, the coefficient of kinetic friction drops to 0.05 from 0.52, and surface lubrication has substantially
Improve.Repeat pull 40 times, coefficient of friction is unchanged.
Embodiment 2
Take the clean medical polyvinyl conduits of 10g, at 25 DEG C, coating medical polyurethane coating under 60% damp condition
(medical polyurethane concentration is 1wt%, and coating thickness is 10nm), dries, and cleans, vacuum drying.It is 50W, oxygen in power
Flow carries out plasma activation 15min for 50mL/min.The analytically pure N- ethylene of 5g is separately added in the there-necked flask of 200ml
Ketopyrrolidine, 95g distilled water.Medical polyvinyl conduit after activation is added in there-necked flask, under 45 DEG C of oil baths, nitrogen
Gas shielded condition, magnetic agitation 12h.After reaction, medical polyvinyl conduit is cleaned into 24h in 60 DEG C of distilled water, it is middle
At least replacing distilled water 15 times, is then cleaned by ultrasonic 1h in ethanol, and 60 DEG C are dried under vacuum to constant weight.
In the case of the Catheter wetting for preparing, the coefficient of kinetic friction drops to 0.04 from 0.48, and surface lubrication has substantially
Improve.Repeat pull 40 times, coefficient of friction is unchanged.
Embodiment 3
Take the clean medical polyvinyl conduits of 10g, at 35 DEG C, coating medical polyurethane coating under 60% damp condition
(medical polyurethane concentration is 30wt%, and coating thickness is 100nm), dries, and cleans, vacuum drying.In 70 DEG C, 15mg/L,
50min is activated in the ozone of 200L/h.The analytically pure acrylic acid of 3g, 97g distillations are separately added in the there-necked flask of 200ml
Water.Medical polyvinyl conduit after activation is added in there-necked flask, under 30 DEG C of oil baths, nitrogen protective condition, magnetic force
Stirring 2h.After reaction, medical polyvinyl conduit is cleaned into 12h in 30 DEG C of distilled water, at least replacing distilled water 10 times, then
It is cleaned by ultrasonic 30min in ethanol, 40 DEG C are dried under vacuum to constant weight.Then in 70 DEG C, 15mg/L, activate in the ozone of 200L/h
60min.The analytically pure acrylamides of 5g, 97g distilled water and 0.5g ammonium ceric nitrates are separately added in the there-necked flask of 200ml.
Medical polyvinyl conduit after activation is added in there-necked flask, under 70 DEG C of oil baths, nitrogen protective condition, magnetic agitation
5h.After reaction, medical polyvinyl conduit is washed into 12h in 60 DEG C of distilled water, it is middle at least to change distilled water 15 times, so
It is cleaned by ultrasonic 1h afterwards in ethanol, 60 DEG C are dried under vacuum to constant weight.
In the case of the Catheter wetting for preparing, the coefficient of kinetic friction drops to 0.015 from 0.50, and surface lubrication has substantially
Improve.Repeat pull 40 times, coefficient of friction is unchanged.
Embodiment 4
Take the clean medical polyvinyl conduits of 10g, at 30 DEG C, coating medical polyurethane coating under 45% damp condition
(medical polyurethane concentration is 10wt%, and coating thickness is 40nm), dries, and cleans, vacuum drying.It is 100 μ W/cm in intensity2
It is ultraviolet under the conditions of irradiate 2h.The analytically pure hydroxyethyl methylacrylates of 10g are separately added in the there-necked flask of 200ml,
100g distilled water, 0.5g benzoyl peroxides.Medical polyvinyl conduit after activation is added in there-necked flask, at 60 DEG C
Under oil bath, nitrogen protective condition, magnetic agitation 12h.After reaction, medical polyvinyl conduit is washed in 60 DEG C of distilled water
24h, middle at least replacing distilled water 15 times, is then cleaned by ultrasonic 1h in ethanol, and 60 DEG C are dried under vacuum to constant weight.
In the case of the Catheter wetting for preparing, the coefficient of kinetic friction drops to 0.09 from 0.48, and surface lubrication has substantially
Improve.Repeat pull 40 times, coefficient of friction is unchanged.
Embodiment 5
The clean medical polyvinyl conduits of 10g are taken, at 20 DEG C, polyurethane coating is coated under 35% damp condition (medical
Polyurethane concentration is 10wt%, and coating thickness is 75nm), dry, clean, vacuum drying.It is 100W, oxygen flow in power
Plasma activation 30min is carried out for 50mL/min.The analytically pure acrylic acid of 10g is separately added in the there-necked flask of 200ml,
100g distilled water.Medical polyvinyl conduit after activation is added in there-necked flask, under 45 DEG C of oil baths, nitrogen ceiling
Part, magnetic agitation 12h.After reaction, medical polyvinyl conduit is cleaned into 24h in 60 DEG C of distilled water, centre is at least changed
Distilled water 15 times, is then cleaned by ultrasonic 1h, 60 DEG C of vacuum drying in ethanol.Then it is being 100W, oxygen flow in power
Plasma activation 60min is carried out for 50mL/min.The analytically pure polyoxyethylenes of 10g are separately added in the there-necked flask of 200ml
Alkene, 100g toluene, 0.5g Oleum Ricini.Medical polyvinyl conduit after activation is added in there-necked flask in 60 DEG C of oil baths
Under, nitrogen protective condition, magnetic agitation 12h.After reaction, medical polyvinyl conduit is washed into 24h in 60 DEG C of distilled water,
Middle at least replacing distilled water 15 times, is then cleaned by ultrasonic 1h in ethanol, and 60 DEG C are dried under vacuum to constant weight.
In the case of the Catheter wetting for preparing, the coefficient of kinetic friction drops to 0.12 from 0.48, and surface lubrication has substantially
Improve.Repeat pull 40 times, coefficient of friction is unchanged.
Embodiment 6
Take the clean medical polyvinyl conduits of 10g, at 10 DEG C, coating medical polyurethane coating under 20% damp condition
(medical polyurethane concentration is 15wt%, and coating thickness is 100nm), dries, and cleans, vacuum drying.In 50mW/cm2It is ultraviolet
Under the conditions of irradiate 5min.The analytically pure acrylic acid of 0.5g, 99.5g distilled water are separately added in the there-necked flask of 200ml.Will be living
Medical polyvinyl conduit after change is added in there-necked flask, under 30 DEG C of oil baths, nitrogen protective condition, and magnetic agitation 2h.
After reaction, medical polyvinyl conduit is cleaned into 18h in 45 DEG C of distilled water, at least replacing distilled water 10 times, then in ethanol
Middle ultrasonic cleaning 45min, 40 DEG C are dried under vacuum to constant weight.Then in 50mW/cm2It is ultraviolet under the conditions of irradiate 5min.In 200ml
There-necked flask in be separately added into the analytically pure acrylamides of 1g, 94g ethanol and 5g benzophenone.Medical polychlorostyrene after by activation
Ethylene conduit is added in there-necked flask, under 30 DEG C of oil baths, nitrogen protective condition, and magnetic agitation 1h.After reaction, will be medical poly-
Vinyl chloride conduit washs 18h in 30 DEG C of distilled water, and then middle at least replacing distilled water 15 times is cleaned by ultrasonic in ethanol
45min, 60 DEG C are dried under vacuum to constant weight.
In the case of the Catheter wetting for preparing, the coefficient of kinetic friction drops to 0.1 from 0.35, and surface lubrication has and substantially carries
It is high.Repeat pull 40 times, coefficient of friction is unchanged.
Embodiment 7
Take the clean medical polyvinyl conduits of 10g, at 40 DEG C, coating medical polyurethane coating under 70% damp condition
(medical polyurethane concentration is 15wt%, and coating thickness is 200nm), dries, and cleans, vacuum drying.In 50uW/cm2It is ultraviolet
Under the conditions of irradiate 8h.The analytically pure acrylic acid of 25g, 75g distilled water are separately added in the there-necked flask of 200ml.After activating
Medical polyvinyl conduit be added in there-necked flask, under 80 DEG C of oil baths, nitrogen protective condition, magnetic agitation 12h.Reaction
Afterwards, medical polyvinyl conduit is cleaned into 18h in 45 DEG C of distilled water, at least replacing distilled water 10 times, is then surpassed in ethanol
Sound cleans 45min, and 40 DEG C are dried under vacuum to constant weight.Then in 50uW/cm2It is ultraviolet under the conditions of irradiate 8h.At three mouthfuls of 200ml
The analytically pure polyvinyl alcohol of 20g, 75g dichloromethane and 5g ethylene glycol are separately added in flask.Medical polychlorostyrene second after by activation
Alkene conduit is added in there-necked flask, under 80 DEG C of oil baths, nitrogen protective condition, and magnetic agitation 36h.After reaction, will be medical poly-
Vinyl chloride conduit washs 18h in 45 DEG C of distilled water, and then middle at least replacing distilled water 15 times is cleaned by ultrasonic in ethanol
45min, 60 DEG C are dried under vacuum to constant weight.
In the case of the Catheter wetting for preparing, the coefficient of kinetic friction drops to 0.05 from 0.35, and surface lubrication has substantially
Improve.Repeat pull 40 times, coefficient of friction is unchanged.
Claims (8)
1. a kind of method for preparing lubricating coating in medical polyvinyl material surface, it is characterised in that comprise the steps：
Step one, by medical polyvinyl material clean, drying, afterwards in surface-coated medical polyurethane coating, dry, wash
Only, it is dried；
Step 2, the medical polyvinyl material for obtaining step one carry out pretreatment, and the pretreatment includes that ozone, ion splash
Penetrate or ultraviolet light；
Step 3, the medical polyvinyl material for obtaining step 2 are added in reaction solution that grafting is anti-under anaerobic
Should, wherein, reaction temperature is 30 DEG C～80 DEG C, and the response time is 1h～36h；The reaction solution includes reaction dissolvent, lubrication
Layer material and reaction additives, lubricating layer quality of materials percentage ratio be 1%～20%, reaction additives mass percent be 0～
5%；
Step 4, by grafting reacted medical polyvinyl material washing, be dried to obtain the product.
2. the method for preparing lubricating coating in medical polyvinyl material surface according to claim 1, its feature exist
In also comprising the steps between step one and step 2：The medical polyvinyl material that step one is obtained carries out pretreatment,
The pretreatment includes ozone, ion sputtering or ultraviolet light；Afterwards by medical polyvinyl material be added to 0.5wt%～
In 25wt% acrylic acid solutions, 2～12h is reacted at 30～80 DEG C；After reaction terminates, clean, be dried.
3. the method for preparing lubricating coating in medical polyvinyl material surface according to claim 1 and 2, its feature
It is described in step one, to be applied to physics coating, medical polyurethane concentration is 1wt%～30wt%, is in 10～40 DEG C, humidity
It is coated under conditions of 20%～70%, coating thickness is 10nm～1000nm.
4. the method for preparing lubricating coating in medical polyvinyl material surface according to claim 1 and 2, its feature
It is that medical polyurethane described in step one is medical Polyester polyurethane, medical polyethers system polyurethane, medical fat adoption urethane
Or medical aromatic urethane.
5. the method for preparing lubricating coating in medical polyvinyl material surface according to claim 1 and 2, its feature
It is that the ozone is processed：Ozone concentration is 1～50mg/L, and ozone flow is 100～600L/h, and treatment temperature is 0～70
DEG C, process time is 10～180min；Ion sputtering is processed：Under oxygen atmosphere, ion sputtering power is 10～300W, is processed
Time is 1～60min；Ultraviolet light process：Ultraviolet ray intensity is 50 μ W/cm2～50mW/cm2, process time be 5min～
8h。
6. the method for preparing lubricating coating in medical polyvinyl material surface according to claim 1 and 2, which is special
Levy and be, reaction dissolvent described in step 3 includes water, methanol, ethanol, acetone, butanone, hexamethylene, toluene, ethyl acetate, heptan
One or more in alkane, chloroform, dichloromethane, tetrahydrofuran, N-N dimethylformamides.
7. the method for preparing lubricating coating in medical polyvinyl material surface according to claim 1 and 2, its feature
It is that layer material is lubricated described in step 3 includes acrylamide, N,N-DMAA, N- vinylpyrrolidones, poly- second
One or more in alkene pyrrolidone, polyethylene glycol oxide, hydroxyethyl methylacrylate, 2-(Acryloyloxy)ethanol, polyvinyl alcohol.
8. the method for preparing lubricating coating in medical polyvinyl material surface according to claim 1 and 2, its feature
It is that reaction additives described in step 3 include Oleum Ricini, benzophenone, persulfate, nitric acid, ammonium ceric nitrate, benzoyl peroxide
One or more in formyl, ethylene glycol, Polyethylene Glycol adipic acid ester, triethylene glycol diacrylate.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110522953A (en) * | 2018-05-24 | 2019-12-03 | 中国科学院兰州化学物理研究所 | A kind of bionic joint lubricant and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105327437A (en) * | 2015-11-19 | 2016-02-17 | 绍兴新原力科技有限公司 | Hydrophilic type super-lubricity urinary catheter and preparation method thereof |
| CN111365534B (en) * | 2020-03-13 | 2021-02-02 | 中国热带农业科学院农产品加工研究所 | Polymer coating natural latex tube and preparation method thereof |
| CN115364281A (en) * | 2022-08-16 | 2022-11-22 | 珠海金导医疗科技有限公司 | Ultrasonic developing lubricating medical catheter and preparation method thereof |
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| CN101612421A (en) * | 2009-07-09 | 2009-12-30 | 东南大学 | The method that has the lubricating coating of stiff stability in the medical polyurethane surface preparation |
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| CN110522953A (en) * | 2018-05-24 | 2019-12-03 | 中国科学院兰州化学物理研究所 | A kind of bionic joint lubricant and preparation method thereof |
| CN110522953B (en) * | 2018-05-24 | 2022-02-15 | 中国科学院兰州化学物理研究所 | Bionic joint lubricant and preparation method thereof |
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| CN104177641A (en) | 2014-12-03 |
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