CN104558666A - Interventional catheter surface treatment method and interventional catheter - Google Patents
Interventional catheter surface treatment method and interventional catheter Download PDFInfo
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- CN104558666A CN104558666A CN201510038107.XA CN201510038107A CN104558666A CN 104558666 A CN104558666 A CN 104558666A CN 201510038107 A CN201510038107 A CN 201510038107A CN 104558666 A CN104558666 A CN 104558666A
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Abstract
The invention provides an interventional catheter surface treatment method and an interventional catheter. The surface treatment method comprises the following steps: performing pretreatment and modification treatment; coating a first coating; and coating a second coating and performing post-treatment. By adopting the surface treatment method provided by the invention, the problems of insufficient wetting property of a coating material on the surface of the interventional catheter and insufficient firmness of a hydrophilic coating are effectively solved; and by combining plasma treatment, grafting, coating of a double-coating system and other means, the purposes of connecting covalent bonds of the bottoms of the coatings and the catheter and closely combining the bottom coating and the top coating are achieved, and the friction force of the interventional catheter after treatment in a water environment is reduced by above 90%.
Description
Technical field
The present invention relates to medical instruments field, be specifically related to a kind of interposing catheter surface treatment method and the interposing catheter through this disposal methods.
Background technology
Endovascular Interventions technology is widely used in the aspects such as the removing of clinical vascular radiography, angioplasty, Intravascular Thrombus or foreign matter, compare with traditional medical skill, not only easy to operate, and due to the wound of interventional therapy low, the misery of patient can be alleviated, Operative risk is less, and medical expense is also relatively low, and therefore this technology obtains at medical field and promotes widely and use.Endovascular Interventions technology arrives diseased region far away in body by means of interposing catheter by vessel lumen, as vascular sites such as coronary arteries, and the diagnosis and treatment agent or insert apparatus, to reach the object to realizing diagnosis and minimally-invasive treatment in body compared with distal part position of reinjecting.Research of Intravascular Catheterization is one of main apparatus of endovascular temporary embolization, its kind can have radiography interposing catheter, drug conveying interposing catheter, angioplasty interposing catheter etc., these interposing catheters should have excellent operability and security, general need excellent blood compatibility, certain blood property of softening, ooze out without nuisance, excellent kink resistance, excellent mechanical property, good workability, and X-ray opacifying agent there is the performances such as good consistency.
Oilness is one of very important performance of Research of Intravascular Catheterization.When conduit is when entering, exiting blood vessel and move in the blood vessel, high lubricity can suppress macromole in blood if plasma proteins, thrombocyte etc. are in the adhesion of material surface, reduce the damage to vessel wall and hemocyte, alleviate the disturbance to blood laminar flow, the generation of Coagulation test can be avoided.Therefore, it is very necessary for carrying out surface lubrication process to interposing catheter.
Summary of the invention
In view of above-mentioned deficiency, the object of this invention is to provide a kind of surface treatment method and the interposing catheter that can obtain the interposing catheter of excellent Hydrophilic lubrication and wear resistance.
Technical scheme of the present invention is as follows:
A kind of interposing catheter surface treatment method, comprises the steps:
S100: pre-treatment: Cement Composite Treated by Plasma is carried out to interposing catheter;
S200: modification: will soak in modified solution through pretreated interposing catheter and to take out after certain hour and to carry out carrying out washing treatment and drying treatment;
S300: apply the first coating: priming paint be coated to the surface of the interposing catheter that step S200 obtains and solidify;
S400: apply the second coating: the interposing catheter surface obtained to step S300 by top layer paint is also solidified;
S500: aftertreatment: the interposing catheter obtained by step S400 immerses in strong aqua, carries out drying treatment after taking-up.
Wherein, Cement Composite Treated by Plasma described in step S100 is be placed in the sample chamber of plasma body generator by interposing catheter, and carry out plasma treatment after passing into gas, wherein discharge power is 10W to 300W, and the treatment time is 1min to 5min.
Wherein, described gas is one or more in helium, argon gas, oxygen or nitrogen.
Wherein, in step S200, described modified solution is acrylic acid aqueous solution, and the mass percent concentration of wherein said acrylic acid aqueous solution is 5% to 95%, and temperature is 30 DEG C to 90 DEG C, and the soak time of interposing catheter is 2h to 24h.
Wherein, the drying temperature of the drying treatment in step S200 is 75 DEG C to 85 DEG C, and time of drying is 10h to 14h.
Wherein, the preparation method of described priming paint is: be added in container by aqueous polyurethane, polyfunctionality aziridine derivative, Siloxane-Oxyalkylene Copolymers and deionized water, at room temperature stir 25 minutes to 35 minutes, priming paint can be obtained, the quality of wherein said polyfunctionality aziridine derivative is 1% ~ 10% of described aqueous polyurethane quality, the quality of described Siloxane-Oxyalkylene Copolymers is 0.05% ~ 0.15% of described aqueous polyurethane quality, and the quality of described deionized water is 80% ~ 99% of priming paint total mass.
Wherein, described polyfunctionality aziridine derivative is one or more in TriMethylolPropane(TMP)-three [3-(2-methylaziridine base)] propionic ester, TriMethylolPropane(TMP)-three (3-'-aziridino) propionic ester and tetramethylolmethane-three (3-'-aziridino) propionic ester.
Wherein, the preparation method of described top layer coating is: be added in container by polymethyl vinyl ether-maleic anhydride, poly glycol monomethyl ether and organic solvent, at room temperature stir 25 minutes to 35 minutes, top layer coating can be obtained, wherein the quality of poly glycol monomethyl ether is 1% ~ 20% of polymethyl vinyl ether-maleic anhydride quality, and the quality of organic solvent is 80% ~ 99% of top layer coating total mass.
Wherein, described organic solvent is N, one or more in dinethylformamide, N,N-dimethylacetamide, N-Methyl pyrrolidone, N, N-dimethyl sulfoxide (DMSO), ethyl acetate, N-BUTYL ACETATE, methylene dichloride, trichloromethane, acetone, butanone and tetrahydrofuran (THF).
Wherein, the solidification value in step S300 is 55 DEG C to 65 DEG C, and set time is 0.8h to 1.2h; Solidification value in step S400 is 75 DEG C to 85 DEG C, and set time is 0.8h to 1.2h; The immersion time in step S500 is 0.9h to 1.3h, and drying temperature is 55 DEG C to 70 DEG C, and time of drying is 11h to 13h.A kind of interposing catheter, comprise catheter main body, the surface of described catheter main body adopts above-mentioned interposing catheter surface treatment method to process.
The invention has the beneficial effects as follows:
(1) the present invention efficiently solves the problem of interposing catheter topcoating wettability and hydrophilic coating stability deficiency, by means such as binding plasma process, grafting, two layer coating system coatings, reach the object being connected with the covalent linkage of conduit and combining closely between base coat and Topcoating bottom coating, make treated interposing catheter friction in water surrounding reduce by more than 90%.
(2) the present invention can be interposing catheter surface and provides firmly hydrophilic lubrication performance, especially be applicable to being applied to the macromolecular material base material being usually difficult to bond, the base materials such as such as ethylene-tetrafluoroethylene copolymer, R 1216-TFE copolymer, polypropylene, polyethylene, the scope of application is wider, the medicine equipment that can be used for comprises outer sheath, convergent divergent channel in vagina vasorum assembly, tears sheath, and seal wire, foley's tube, guiding catheter, thrombus suction catheter, peripheral central venous catheter, angiography catheter etc.
Embodiment
In order to make the object of interposing catheter surface treatment method of the present invention and interposing catheter, technical scheme and advantage clearly understand, below in conjunction with specific embodiment, the present invention is further elaborated.
It should be noted that, when not conflicting, the embodiment in the application and the feature in embodiment can combine mutually.
The present invention is by carrying out Cement Composite Treated by Plasma to interposing catheter surface, and graft acrylic acid, make surface containing activated carboxyl, then by building two layer coating system, form many components crosslinking structure with different chemical bond mode of connection.Wherein, can react with aziridine group to make polymethyl vinyl ether-maleic anhydride, adopt poly glycol monomethyl ether and maleic groups generation esterification partly, be grafted on the molecular skeleton of polymethyl vinyl ether-maleic anhydride, obtain the carboxyl that can react with aziridine group simultaneously, in addition the Oxyerhylene on poly glycol monomethyl ether can also play hydrophilic effect, such polyfunctionality aziridine derivative act as linking conduit surface carboxyl groups, urethane in first coating, the linking agent of hydrophilic polymer polymethyl vinyl ether-maleic anhydride, coating outer surface is made both to have had the effect of hydrophilic lubrication, in turn ensure that and be connected with the covalent linkage of conduit bottom coating, and first the combining closely between coating and the second coating, make crocking resistance excellent.
Interposing catheter surface treatment method of the present invention, comprises the steps:
S100: pre-treatment: Cement Composite Treated by Plasma is carried out to interposing catheter.
Wherein, described Cement Composite Treated by Plasma is be placed in the sample chamber of plasma body generator by interposing catheter, and carry out plasma treatment after passing into gas, wherein discharge power is 10W to 300W, and the treatment time is 1min to 5min.The gas passed in this step is one or more in helium, argon gas, oxygen or nitrogen.Cement Composite Treated by Plasma is the plasma bombardment material surface utilizing gas, makes the molecular rupture of material surface, combination, generation free radical etc., thus makes material surface obtain modification.
S200: modification: will soak in modified solution after certain hour through pretreated interposing catheter and take out interposing catheter, with deionized water wash for several times until the pH value of washing liq (i.e. deionized water) does not change, afterwards this interposing catheter is placed in vacuum drying oven, takes out after dry 10h to 14h at being preferably 80 DEG C at 75 DEG C to 85 DEG C.Modified solution described in this step is acrylic acid aqueous solution, and in wherein said acrylic acid aqueous solution, acrylic acid mass percent concentration is 5% to 95%, and temperature is 30 DEG C to 90 DEG C, and the soak time of interposing catheter is 2h to 24h.By carrying out grafting to interposing catheter surface, make interposing catheter surface containing more pendant carboxylic group.
S300: apply the first coating: surface priming paint being coated to the interposing catheter that step S200 obtains, and 1h is solidified at 60 DEG C;
S400: apply the second coating: 1h is also solidified in the interposing catheter surface obtained to step S300 by top layer paint at 80 DEG C.
When only with single polymer-coated interposing catheter surface, this coating easily comes off after absorbing water, and due to the restriction of interposing catheter grafting efficiency, the tie point on polymkeric substance and interposing catheter surface is limited, adopt double-deck coating in the present invention, form polycomponent crosslinking structure by different chemical bond mode of connection.
S500: aftertreatment: the interposing catheter that obtained by step S400 immerses in strong aqua, at room temperature soaks 1h, after taking-up at 60 DEG C dry 12h, surface can be obtained there is excellent hydrophilic lubrication coating and the interposing catheter of wear resistance.The object of this step makes remaining anhydride group open loop in polymethyl vinyl ether-maleic anhydride and forms ammonium salt, and then obtain hydrophile function.
Preferably, the thickness of the first coating is 1 ~ 10 micron, and the second coat-thickness is 1 ~ 10 micron, and the thickness ratio of the first coat-thickness and the second coating is 1:1 to 1:1.5.Second coating is thicker can make the functional group reactions in the first coating complete.
Preferably, the preparation method of described priming paint is: by aqueous polyurethane, polyfunctionality aziridine derivative, Siloxane-Oxyalkylene Copolymers and deionized water are added in container, at room temperature stir 25 minutes to 35 minutes, priming paint can be obtained, the quality of wherein said polyfunctionality aziridine derivative is 1% ~ 10% of described aqueous polyurethane quality, the quality of described Siloxane-Oxyalkylene Copolymers is 0.05% ~ 0.15% (being preferably 0.1%) of described aqueous polyurethane quality, the quality of described deionized water is 80% ~ 99% of priming paint total mass.
Further, described polyfunctionality aziridine derivative is one or more in TriMethylolPropane(TMP)-three [3-(2-methylaziridine base)] propionic ester, TriMethylolPropane(TMP)-three (3-'-aziridino) propionic ester and tetramethylolmethane-three (3-'-aziridino) propionic ester.
Preferably, the preparation method of described top layer coating is: be added in container by polymethyl vinyl ether-maleic anhydride, poly glycol monomethyl ether and organic solvent, at room temperature stir 25 minutes to 35 minutes, top layer coating can be obtained, wherein the quality of poly glycol monomethyl ether is 1% ~ 20% of polymethyl vinyl ether-maleic anhydride quality, and the quality of organic solvent is 80% ~ 99% of top layer coating total mass.
Further, described organic solvent is N, one or more in dinethylformamide, N,N-dimethylacetamide, N-Methyl pyrrolidone, N, N-dimethyl sulfoxide (DMSO), ethyl acetate, N-BUTYL ACETATE, methylene dichloride, trichloromethane, acetone, butanone and tetrahydrofuran (THF).
Preferably, the per-cent that the deionized water in described priming paint accounts for priming paint total mass is equal with the mass percent that the organic solvent in top layer coating accounts for top layer coating total mass.
The present invention also provides a kind of and adopts above-mentioned interposing catheter surface treatment method to carry out the interposing catheter processed.This interposing catheter has good Hydrophilic lubrication and wear resistance.
Embodiment one
Preparation work:
(1) priming paint is prepared: be added in container by aqueous polyurethane, TriMethylolPropane(TMP)-three [3-(2-methylaziridine base)] propionic ester, Siloxane-Oxyalkylene Copolymers, deionized water, at room temperature stir 30 minutes, obtain priming paint, wherein the quality of TriMethylolPropane(TMP)-three [3-(2-methylaziridine base)] propionic ester is 1% of aqueous polyurethane quality, the quality of Siloxane-Oxyalkylene Copolymers is 0.1% of aqueous polyurethane quality, and the quality of deionized water is 80% of priming paint total mass.
(2) top layer coating is prepared: by polymethyl vinyl ether-maleic anhydride, poly glycol monomethyl ether, N, dinethylformamide adds in container, at room temperature stir 30 minutes, obtain top layer coating, wherein the quality of poly glycol monomethyl ether is 1% of polymethyl vinyl ether-maleic anhydride quality, the quality of DMF is 80% of top layer coating total mass.
Wherein, polymethyl vinyl ether-maleic anhydride is Sigma-Aldrich, number-average molecular weight is the product of 80000, aqueous polyurethane is Lubrizol Corp. Sancure 777 type product, poly glycol monomethyl ether is Sigma-Aldrich, number-average molecular weight is the product of 1000, Siloxane-Oxyalkylene Copolymers is Ying Chuan industrial Tego Wet 260 type product, and all the other are commercially available.(following examples are identical)
Preparation process:
S100: be positioned over by interposing catheter in the sample chamber of plasma body generator, carries out Cement Composite Treated by Plasma after passing into argon gas, and discharge power is 10W, and the treatment time is 1min, is taken out by this interposing catheter after having processed;
S200: the interposing catheter obtained by step S100 is soaked in the acrylic acid aqueous solution of 5wt% concentration and carries out graft modification, grafting temperature is 30 DEG C, grafting time is 2h, react rear taking-up interposing catheter, with deionized water wash several, until the pH value of washing liq no longer changes, afterwards conduit is positioned in vacuum drying oven, takes out after dry 12 hours at 80 DEG C;
S300: the surface above-mentioned priming paint being coated to the interposing catheter that step S200 obtains, solidifies 0.8h to 1.2h in 55 DEG C at 65 DEG C;
S400: the interposing catheter obtained to step S300 by above-mentioned top layer paint on the surface, solidifies 0.8h to 1.2h in 75 DEG C at 85 DEG C;
S500: the interposing catheter obtained by step S400 is immersed in strong aqua, at room temperature soak 0.9h to 1.3h, after taking-up at 55 DEG C to 70 DEG C dry 11h to 13h, the interposing catheter that surface has hydrophilic lubrication coating can be obtained.Strong aqua is commercial chemicals, and concentration is 22% to 30%.
Interposing catheter oilness testing method is as follows: carry out surface treatment of the present invention in the half of interposing catheter, and second half interposing catheter does not process.Afterwards interposing catheter one end is vertically fixed in the lower clamp of drawing machine, at interposing catheter surface clamping self-control slide block, this slide block can be screwed on conduit and also give conduit fixing pressure by inner rubber ring, the inner interlayer of slide block can carry the deionized water of certain volume, can implement to infiltrate continuously to interposing catheter, with the upper clamp clamping slide block being connected with mechanics sensor in drawing machine, slide block is pulled to interposing catheter top from interposing catheter bottom according to fixed speed, then the stressed change of sensor embodies the frictional force that interposing catheter is subject on two kinds of surfaces, the difference of friction value reflects the Hydrophilic lubrication of conduit.(coating layer portion is stressed is Fpr1 to the friction value of record corresponding to two portions centre of surface position, without coating layer portion stressed be Fpr2), then can obtain the amplitude that water-wetted surface frictional force reduces, be designated as fp-r, fp-r=(Fpr2-Fpr1)/Fpr2 × 100%, fp-r value is larger, illustrates that oilness is better.
After tested, in the present embodiment, interposing catheter friction reduces degree fp-r value higher than 90%.
Embodiment two
Preparation work:
(1) priming paint is prepared: be added in container by aqueous polyurethane, TriMethylolPropane(TMP)-three (3-'-aziridino) propionic ester, Siloxane-Oxyalkylene Copolymers, deionized water, at room temperature stir 30 minutes, obtain priming paint, wherein the quality of TriMethylolPropane(TMP)-three (3-'-aziridino) propionic ester is 2% of aqueous polyurethane quality, the quality of Siloxane-Oxyalkylene Copolymers is 0.05% of aqueous polyurethane quality, and the quality of deionized water is 85% of priming paint total mass.
(2) top layer coating is prepared: by polymethyl vinyl ether-maleic anhydride, poly glycol monomethyl ether, N, N-N,N-DIMETHYLACETAMIDE adds in container, at room temperature stir 30 minutes, obtain top layer coating, wherein the quality of poly glycol monomethyl ether is 5% of polymethyl vinyl ether-maleic anhydride quality, the quality of N,N-dimethylacetamide is 85% of top layer coating total mass.
Preparation process:
S100: be positioned over by interposing catheter in the sample chamber of plasma body generator, carries out Cement Composite Treated by Plasma after passing into helium, and discharge power is 50W, and the treatment time is 2min, is taken out by this interposing catheter after having processed;
S200: the interposing catheter obtained by step S100 is soaked in the acrylic acid aqueous solution of 10wt% concentration and carries out graft modification, grafting temperature is 40 DEG C, grafting time is 6h, react rear taking-up interposing catheter, with deionized water wash several, until the pH value of washing liq no longer changes, afterwards conduit is positioned in vacuum drying oven, takes out after dry 12 hours at 80 DEG C;
S300: the surface priming paint in the present embodiment being coated to the interposing catheter that step S200 obtains, solidifies 1h at 60 DEG C;
S400: the interposing catheter obtained to step S300 by the top layer paint in the present embodiment on the surface, solidifies 1h at 80 DEG C;
S500: the interposing catheter obtained by step S400 is immersed in strong aqua, at room temperature soaks 1h, after taking-up at 60 DEG C dry 12h, the interposing catheter that surface has hydrophilic lubrication coating can be obtained.
Oilness testing method is identical with embodiment one.
After tested, in the present embodiment, interposing catheter friction reduces degree fp-r value is 95%.
Embodiment three
Preparation work:
(1) priming paint is prepared: be added in container by aqueous polyurethane, tetramethylolmethane-three (3-'-aziridino) propionic ester, Siloxane-Oxyalkylene Copolymers, deionized water, at room temperature stir 30 minutes, obtain priming paint, wherein the quality of tetramethylolmethane-three (3-'-aziridino) propionic ester is 3% of aqueous polyurethane quality, the quality of Siloxane-Oxyalkylene Copolymers is 0.15% of aqueous polyurethane quality, and the quality of deionized water is 90% of priming paint total mass.
(2) top layer coating is prepared: add in container by polymethyl vinyl ether-maleic anhydride, poly glycol monomethyl ether, N-Methyl pyrrolidone, at room temperature stir 30 minutes, obtain top layer coating, wherein the quality of poly glycol monomethyl ether is 10% of polymethyl vinyl ether-maleic anhydride quality, and the quality of N-Methyl pyrrolidone is 90% of top layer coating total mass.
Preparation process:
S100: be positioned over by interposing catheter in the sample chamber of plasma body generator, carries out Cement Composite Treated by Plasma after passing into oxygen, and discharge power is 100W, and the treatment time is 3min, is taken out by this interposing catheter after having processed;
S200: the interposing catheter obtained by step S100 is soaked in the acrylic acid aqueous solution of 20wt% concentration and carries out graft modification, grafting temperature is 50 DEG C, grafting time is 10h, react rear taking-up interposing catheter, with deionized water wash several, until the pH value of washing liq no longer changes, afterwards conduit is positioned in vacuum drying oven, takes out after dry 12 hours at 80 DEG C;
S300: the surface above-mentioned priming paint being coated to the interposing catheter that step S200 obtains, solidifies 1h at 60 DEG C;
S400: the interposing catheter obtained to step S300 by above-mentioned top layer paint on the surface, solidifies 1h at 80 DEG C;
S500: the interposing catheter obtained by step S400 is immersed in strong aqua, at room temperature soaks 1h, after taking-up at 60 DEG C dry 12h, the interposing catheter that surface has hydrophilic lubrication coating can be obtained.
Oilness testing method is identical with embodiment one.
After tested, in the present embodiment, interposing catheter friction reduces degree fp-r value is 94%.
Embodiment four
Preparation work:
(1) priming paint is prepared: be added in container by aqueous polyurethane, TriMethylolPropane(TMP)-three [3-(2-methylaziridine base)] propionic ester, Siloxane-Oxyalkylene Copolymers, deionized water, at room temperature stir 25 minutes, obtain priming paint, wherein the quality of TriMethylolPropane(TMP)-three [3-(2-methylaziridine base)] propionic ester is 4% of aqueous polyurethane quality, the quality of Siloxane-Oxyalkylene Copolymers is 0.1% of aqueous polyurethane quality, and the quality of deionized water is 95% of priming paint total mass.
(2) top layer coating is prepared: by polymethyl vinyl ether-maleic anhydride, poly glycol monomethyl ether, N, N-dimethyl sulfoxide (DMSO) adds in container, at room temperature stir 30 minutes, obtain top layer coating, wherein the quality of poly glycol monomethyl ether is 15% of polymethyl vinyl ether-maleic anhydride quality, the quality of N, N-dimethyl sulfoxide (DMSO) is 95% of top layer coating total mass.
Preparation process:
S100: be positioned over by interposing catheter in the sample chamber of plasma body generator, carries out Cement Composite Treated by Plasma after passing into nitrogen, and discharge power is 150W, and the treatment time is 4min, is taken out by this interposing catheter after having processed;
S200: the interposing catheter obtained by step S100 is soaked in the acrylic acid aqueous solution of 30wt% concentration and carries out graft modification, grafting temperature is 60 DEG C, grafting time is 14h, react rear taking-up interposing catheter, with deionized water wash several, until the pH value of washing liq no longer changes, afterwards conduit is positioned in vacuum drying oven, takes out after dry 12 hours at 80 DEG C;
S300: the surface above-mentioned priming paint being coated to the interposing catheter that step S200 obtains, solidifies 1h at 60 DEG C;
S400: the interposing catheter obtained to step S300 by above-mentioned top layer paint on the surface, solidifies 1h at 80 DEG C;
S500: the interposing catheter obtained by step S400 is immersed in strong aqua, at room temperature soaks 1h, after taking-up at 60 DEG C dry 12h, the interposing catheter that surface has hydrophilic lubrication coating can be obtained.
Oilness testing method is identical with embodiment one.
After tested, in the present embodiment, interposing catheter friction reduces degree fp-r value is 95%.
Embodiment five
Preparation work:
(1) priming paint is prepared: be added in container by aqueous polyurethane, TriMethylolPropane(TMP)-three (3-'-aziridino) propionic ester, Siloxane-Oxyalkylene Copolymers, deionized water, at room temperature stir 35 minutes, obtain priming paint, wherein the quality of TriMethylolPropane(TMP)-three (3-'-aziridino) propionic ester is 5% of aqueous polyurethane quality, the quality of Siloxane-Oxyalkylene Copolymers is 0.1% of aqueous polyurethane quality, and the quality of deionized water is 99% of priming paint total mass.
(2) top layer coating is prepared: add in container by polymethyl vinyl ether-maleic anhydride, poly glycol monomethyl ether, ethyl acetate, at room temperature stir 25 minutes, obtain top layer coating, wherein the quality of poly glycol monomethyl ether is 20% of polymethyl vinyl ether-maleic anhydride quality, and the quality of ethyl acetate is 99% of top layer coating total mass.
Preparation process:
S100: be positioned over by interposing catheter in the sample chamber of plasma body generator, carries out Cement Composite Treated by Plasma after passing into argon gas and oxygen, and discharge power is 200W, and the treatment time is 5min, is taken out by this interposing catheter after having processed;
S200: the interposing catheter obtained by step S100 is soaked in the acrylic acid aqueous solution of 40wt% concentration and carries out graft modification, grafting temperature is 70 DEG C, grafting time is 18h, react rear taking-up interposing catheter, with deionized water wash several, until the pH value of washing liq no longer changes, afterwards conduit is positioned in vacuum drying oven, takes out after dry 14 hours at 75 DEG C;
S300: the surface above-mentioned priming paint being coated to the interposing catheter that step S200 obtains, solidifies 1h at 60 DEG C;
S400: the interposing catheter obtained to step S300 by above-mentioned top layer paint on the surface, solidifies 1h at 80 DEG C;
S500: the interposing catheter obtained by step S400 is immersed in strong aqua, at room temperature soaks 1h, after taking-up at 60 DEG C dry 12h, the interposing catheter that surface has hydrophilic lubrication coating can be obtained.
Oilness testing method is identical with embodiment one.
After tested, in the present embodiment, interposing catheter friction reduces degree fp-r value higher than 90%.
Embodiment six
Preparation work:
(1) priming paint is prepared: be added in container by aqueous polyurethane, tetramethylolmethane-three (3-'-aziridino) propionic ester, Siloxane-Oxyalkylene Copolymers, deionized water, at room temperature stir 30 minutes, obtain priming paint, wherein the quality of tetramethylolmethane-three (3-'-aziridino) propionic ester is 6% of aqueous polyurethane quality, the quality of Siloxane-Oxyalkylene Copolymers is 0.1% of aqueous polyurethane quality, and the quality of deionized water is 83% of priming paint total mass.
(2) top layer coating is prepared: add in container by polymethyl vinyl ether-maleic anhydride, poly glycol monomethyl ether, N-BUTYL ACETATE, at room temperature stir 35 minutes, obtain top layer coating, wherein the quality of poly glycol monomethyl ether is 3% of polymethyl vinyl ether-maleic anhydride quality, and the quality of N-BUTYL ACETATE is 83% of top layer coating total mass.
Preparation process:
S100: be positioned over by interposing catheter in the sample chamber of plasma body generator, carries out Cement Composite Treated by Plasma after passing into argon gas and oxygen, and discharge power is 250W, and the treatment time is 5min, is taken out by this interposing catheter after having processed;
S200: the interposing catheter obtained by step S100 is soaked in the acrylic acid aqueous solution of 50wt% concentration and carries out graft modification, grafting temperature is 80 DEG C, grafting time is 24h, react rear taking-up interposing catheter, with deionized water wash several, until the pH value of washing liq no longer changes, afterwards conduit is positioned in vacuum drying oven, takes out after dry 12 hours at 80 DEG C;
S300: the surface above-mentioned priming paint being coated to the interposing catheter that step S200 obtains, solidifies 1h at 60 DEG C;
S400: the interposing catheter obtained to step S300 by above-mentioned top layer paint on the surface, solidifies 1h at 80 DEG C;
S500: the interposing catheter obtained by step S400 is immersed in strong aqua, at room temperature soaks 1h, after taking-up at 60 DEG C dry 12h, the interposing catheter that surface has hydrophilic lubrication coating can be obtained.
Oilness testing method is identical with embodiment one.
After tested, in the present embodiment, interposing catheter friction reduces degree fp-r value higher than 90%.
Embodiment seven
Preparation work:
(1) priming paint is prepared: be added in container by aqueous polyurethane, TriMethylolPropane(TMP)-three [3-(2-methylaziridine base)] propionic ester, Siloxane-Oxyalkylene Copolymers, deionized water, at room temperature stir 30 minutes, obtain priming paint, wherein the quality of TriMethylolPropane(TMP)-three [3-(2-methylaziridine base)] propionic ester is 7% of aqueous polyurethane quality, the quality of Siloxane-Oxyalkylene Copolymers is 0.1% of aqueous polyurethane quality, and the quality of deionized water is 87% of priming paint total mass.
(2) top layer coating is prepared: add in container by polymethyl vinyl ether-maleic anhydride, poly glycol monomethyl ether, methylene dichloride, at room temperature stir 30 minutes, obtain top layer coating, wherein the quality of poly glycol monomethyl ether is 7% of polymethyl vinyl ether-maleic anhydride quality, and the quality of methylene dichloride is 87% of top layer coating total mass.
Preparation process:
S100: be positioned over by interposing catheter in the sample chamber of plasma body generator, carries out Cement Composite Treated by Plasma after passing into nitrogen and oxygen, and discharge power is 300W, and the treatment time is 5min, is taken out by this interposing catheter after having processed;
S200: the interposing catheter obtained by step S100 is soaked in the acrylic acid aqueous solution of 60wt% concentration and carries out graft modification, grafting temperature is 90 DEG C, grafting time is 12h, react rear taking-up interposing catheter, with deionized water wash several, until the pH value of washing liq no longer changes, afterwards conduit is positioned in vacuum drying oven, takes out after dry 12 hours at 80 DEG C;
S300: the surface above-mentioned priming paint being coated to the interposing catheter that step S200 obtains, solidifies 1.2h at 55 DEG C;
S400: the interposing catheter obtained to step S300 by above-mentioned top layer paint on the surface, solidifies 1h at 80 DEG C;
S500: the interposing catheter obtained by step S400 is immersed in strong aqua, at room temperature soaks 1h, after taking-up at 60 DEG C dry 12h, the interposing catheter that surface has hydrophilic lubrication coating can be obtained.
Oilness testing method is identical with embodiment one.
After tested, in the present embodiment, interposing catheter friction reduces degree fp-r value higher than 90%.
Embodiment eight
Preparation work:
(1) priming paint is prepared: be added in container by aqueous polyurethane, TriMethylolPropane(TMP)-three (3-'-aziridino) propionic ester, Siloxane-Oxyalkylene Copolymers, deionized water, at room temperature stir 30 minutes, obtain priming paint, wherein the quality of TriMethylolPropane(TMP)-three (3-'-aziridino) propionic ester is 8% of aqueous polyurethane quality, the quality of Siloxane-Oxyalkylene Copolymers is 0.1% of aqueous polyurethane quality, and the quality of deionized water is 89% of priming paint total mass.
(2) top layer coating is prepared: add in container by polymethyl vinyl ether-maleic anhydride, poly glycol monomethyl ether, trichloromethane, at room temperature stir 30 minutes, obtain top layer coating, wherein the quality of poly glycol monomethyl ether is 9% of polymethyl vinyl ether-maleic anhydride quality, and the quality of trichloromethane is 89% of top layer coating total mass.
Preparation process:
S100: be positioned over by interposing catheter in the sample chamber of plasma body generator, carries out Cement Composite Treated by Plasma after passing into argon gas and helium, and discharge power is 30W, and the treatment time is 3min, is taken out by this interposing catheter after having processed;
S200: the interposing catheter obtained by step S100 is soaked in the acrylic acid aqueous solution of 70wt% concentration and carries out graft modification, grafting temperature is 75 DEG C, grafting time is 8h, react rear taking-up interposing catheter, with deionized water wash several, until the pH value of washing liq no longer changes, afterwards conduit is positioned in vacuum drying oven, takes out after dry 10 hours at 85 DEG C;
S300: the surface above-mentioned priming paint being coated to the interposing catheter that step S200 obtains, solidifies 1h at 60 DEG C;
S400: the interposing catheter obtained to step S300 by above-mentioned top layer paint on the surface, solidifies 0.8h at 85 DEG C;
S500: the interposing catheter obtained by step S400 is immersed in strong aqua, at room temperature soaks 1h, after taking-up at 60 DEG C dry 12h, the interposing catheter that surface has hydrophilic lubrication coating can be obtained.
Oilness testing method is identical with embodiment one.
After tested, in the present embodiment, interposing catheter friction reduces degree fp-r value higher than 90%.
Embodiment nine
Preparation work:
(1) priming paint is prepared: be added in container by aqueous polyurethane, tetramethylolmethane-three (3-'-aziridino) propionic ester, Siloxane-Oxyalkylene Copolymers, deionized water, at room temperature stir 30 minutes, obtain priming paint, wherein the quality of tetramethylolmethane-three (3-'-aziridino) propionic ester is 9% of aqueous polyurethane quality, the quality of Siloxane-Oxyalkylene Copolymers is 0.1% of aqueous polyurethane quality, and the quality of deionized water is 91% of priming paint total mass.
(2) top layer coating is prepared: add in container by polymethyl vinyl ether-maleic anhydride, poly glycol monomethyl ether, acetone, at room temperature stir 30 minutes, obtain top layer coating, wherein the quality of poly glycol monomethyl ether is 11% of polymethyl vinyl ether-maleic anhydride quality, and the quality of acetone is 91% of top layer coating total mass.
Preparation process:
S100: be positioned over by interposing catheter in the sample chamber of plasma body generator, carries out Cement Composite Treated by Plasma after passing into argon gas and nitrogen, and discharge power is 70W, and the treatment time is 3min, is taken out by this interposing catheter after having processed;
S200: the interposing catheter obtained by step S100 is soaked in the acrylic acid aqueous solution of 80wt% concentration and carries out graft modification, grafting temperature is 65 DEG C, grafting time is 5h, react rear taking-up interposing catheter, with deionized water wash several, until the pH value of washing liq no longer changes, afterwards conduit is positioned in vacuum drying oven, takes out after dry 12 hours at 80 DEG C;
S300: the surface above-mentioned priming paint being coated to the interposing catheter that step S200 obtains, solidifies 0.8h at 65 DEG C;
S400: the interposing catheter obtained to step S300 by above-mentioned top layer paint on the surface, solidifies 1h at 80 DEG C;
S500: the interposing catheter obtained by step S400 is immersed in strong aqua, at room temperature soaks 1h, after taking-up at 60 DEG C dry 12h, the interposing catheter that surface has hydrophilic lubrication coating can be obtained.
Oilness testing method is identical with embodiment one.
After tested, in the present embodiment, interposing catheter friction reduces degree fp-r value higher than 90%.
Embodiment ten
Preparation work:
(1) priming paint is prepared: be added in container by aqueous polyurethane, TriMethylolPropane(TMP)-three [3-(2-methylaziridine base)] propionic ester, Siloxane-Oxyalkylene Copolymers, deionized water, at room temperature stir 30 minutes, obtain priming paint, wherein the quality of TriMethylolPropane(TMP)-three [3-(2-methylaziridine base)] propionic ester is 10% of aqueous polyurethane quality, the quality of Siloxane-Oxyalkylene Copolymers is 0.1% of aqueous polyurethane quality, and the quality of deionized water is 93% of priming paint total mass.
(2) top layer coating is prepared: add in container by polymethyl vinyl ether-maleic anhydride, poly glycol monomethyl ether, butanone, at room temperature stir 30 minutes, obtain top layer coating, wherein the quality of poly glycol monomethyl ether is 11% of polymethyl vinyl ether-maleic anhydride quality, and the quality of butanone is 93% of top layer coating total mass.
Preparation process:
S100: be positioned over by interposing catheter in the sample chamber of plasma body generator, carries out Cement Composite Treated by Plasma after passing into argon gas, oxygen and helium, and discharge power is 90W, and the treatment time is 5min, is taken out by this interposing catheter after having processed;
S200: the interposing catheter obtained by step S100 is soaked in the acrylic acid aqueous solution of 90wt% concentration and carries out graft modification, grafting temperature is 55 DEG C, grafting time is 15h, react rear taking-up interposing catheter, with deionized water wash several, until the pH value of washing liq no longer changes, afterwards conduit is positioned in vacuum drying oven, takes out after dry 12 hours at 80 DEG C;
S300: the surface above-mentioned priming paint being coated to the interposing catheter that step S200 obtains, solidifies 1h at 60 DEG C;
S400: the interposing catheter obtained to step S300 by above-mentioned top layer paint on the surface, solidifies 1.2h at 75 DEG C;
S500: the interposing catheter obtained by step S400 is immersed in strong aqua, at room temperature soaks 1h, after taking-up at 60 DEG C dry 12h, the interposing catheter that surface has hydrophilic lubrication coating can be obtained.
Oilness testing method is identical with embodiment one.
After tested, in the present embodiment, interposing catheter friction reduces degree fp-r value higher than 90%.
Embodiment 11
Preparation work:
(1) priming paint is prepared: be added in container by aqueous polyurethane, TriMethylolPropane(TMP)-three (3-'-aziridino) propionic ester, Siloxane-Oxyalkylene Copolymers, deionized water, at room temperature stir 30 minutes, obtain priming paint, wherein the quality of TriMethylolPropane(TMP)-three (3-'-aziridino) propionic ester is 5% of aqueous polyurethane quality, the quality of Siloxane-Oxyalkylene Copolymers is 0.1% of aqueous polyurethane quality, and the quality of deionized water is 97% of priming paint total mass.
(2) top layer coating is prepared: add in container by polymethyl vinyl ether-maleic anhydride, poly glycol monomethyl ether, tetrahydrofuran (THF), at room temperature stir 30 minutes, obtain top layer coating, wherein the quality of poly glycol monomethyl ether is 17% of polymethyl vinyl ether-maleic anhydride quality, and the quality of tetrahydrofuran (THF) is 97% of top layer coating total mass.
Preparation process:
S100: be positioned over by interposing catheter in the sample chamber of plasma body generator, carries out Cement Composite Treated by Plasma after passing into argon gas, nitrogen and helium, and discharge power is 110W, and the treatment time is 5min, is taken out by this interposing catheter after having processed;
S200: the interposing catheter obtained by step S100 is soaked in the acrylic acid aqueous solution of 95wt% concentration and carries out graft modification, grafting temperature is 45 DEG C, grafting time is 17h, react rear taking-up interposing catheter, with deionized water wash several, until the pH value of washing liq no longer changes, afterwards conduit is positioned in vacuum drying oven, takes out after dry 12 hours at 80 DEG C;
S300: the surface above-mentioned priming paint being coated to the interposing catheter that step S200 obtains, solidifies 1h at 60 DEG C;
S400: the interposing catheter obtained to step S300 by above-mentioned top layer paint on the surface, solidifies 1h at 80 DEG C;
S500: the interposing catheter obtained by step S400 is immersed in strong aqua, at room temperature soaks 0.9h, after taking-up at 55 DEG C dry 13h, the interposing catheter that surface has hydrophilic lubrication coating can be obtained.
Oilness testing method is identical with embodiment one.
After tested, in the present embodiment, interposing catheter friction reduces degree fp-r value higher than 90%.
Embodiment 12
Preparation work:
(1) priming paint is prepared: by aqueous polyurethane, TriMethylolPropane(TMP)-three (3-'-aziridino) propionic ester, tetramethylolmethane-three (3-'-aziridino) propionic ester, Siloxane-Oxyalkylene Copolymers, deionized water is added in container, at room temperature stir 30 minutes, obtain priming paint, wherein the quality of TriMethylolPropane(TMP)-three (3-'-aziridino) propionic ester is 2% of aqueous polyurethane quality, the quality of tetramethylolmethane-three (3-'-aziridino) propionic ester is 2% of aqueous polyurethane quality, the quality of Siloxane-Oxyalkylene Copolymers is 0.1% of aqueous polyurethane quality, the quality of deionized water is 96% of priming paint total mass.
(2) top layer coating is prepared: add in container by polymethyl vinyl ether-maleic anhydride, poly glycol monomethyl ether, ethyl acetate, methylene dichloride, at room temperature stir 30 minutes, obtain top layer coating, wherein the quality of poly glycol monomethyl ether is 4% of polymethyl vinyl ether-maleic anhydride quality, the quality of ethyl acetate is 50% of top layer coating total mass, and the quality of methylene dichloride is 46% of top layer coating total mass.
Preparation process:
S100: be positioned over by interposing catheter in the sample chamber of plasma body generator, carries out Cement Composite Treated by Plasma after passing into argon gas, nitrogen, oxygen and helium, and discharge power is 130W, and the treatment time is 5min, is taken out by this interposing catheter after having processed;
S200: the interposing catheter obtained by step S100 is soaked in the acrylic acid aqueous solution of 35wt% concentration and carries out graft modification, grafting temperature is 75 DEG C, grafting time is 12h, react rear taking-up interposing catheter, with deionized water wash several, until the pH value of washing liq no longer changes, afterwards conduit is positioned in vacuum drying oven, takes out after dry 12 hours at 80 DEG C;
S300: the surface above-mentioned priming paint being coated to the interposing catheter that step S200 obtains, solidifies 1h at 60 DEG C;
S400: the interposing catheter obtained to step S300 by above-mentioned top layer paint on the surface, solidifies 1h at 80 DEG C;
S500: the interposing catheter obtained by step S400 is immersed in strong aqua, at room temperature soaks 1.3h, after taking-up at 70 DEG C dry 11h, the interposing catheter that surface has hydrophilic lubrication coating can be obtained.
Oilness testing method is identical with embodiment one.
After tested, in the present embodiment, interposing catheter friction reduces degree fp-r value higher than 90%.
Embodiment 13
Preparation work:
(1) priming paint is prepared: by aqueous polyurethane, TriMethylolPropane(TMP)-three [3-(2-methylaziridine base)] propionic ester, TriMethylolPropane(TMP)-three (3-'-aziridino) propionic ester, tetramethylolmethane-three (3-'-aziridino) propionic ester, Siloxane-Oxyalkylene Copolymers, deionized water is added in container, at room temperature stir 30 minutes, obtain priming paint, wherein the quality of TriMethylolPropane(TMP)-three [3-(2-methylaziridine base)] propionic ester is 1% of aqueous polyurethane quality, the quality of TriMethylolPropane(TMP)-three (3-'-aziridino) propionic ester is 1% of aqueous polyurethane quality, the quality of tetramethylolmethane-three (3-'-aziridino) propionic ester is 1% of aqueous polyurethane quality, the quality of Siloxane-Oxyalkylene Copolymers is 0.1% of aqueous polyurethane quality, the quality of deionized water is 96% of priming paint total mass.
(2) top layer coating is prepared: add in container by polymethyl vinyl ether-maleic anhydride, poly glycol monomethyl ether, trichloromethane, acetone, tetrahydrofuran (THF), at room temperature stir 30 minutes, obtain top layer coating, wherein the quality of poly glycol monomethyl ether is 4% of polymethyl vinyl ether-maleic anhydride quality, the quality of trichloromethane is 30% of top layer coating total mass, the quality of acetone is 40% of top layer coating total mass, and the quality of tetrahydrofuran (THF) is 25% of top layer coating total mass.
Preparation process:
S100: be positioned over by interposing catheter in the sample chamber of plasma body generator, carries out Cement Composite Treated by Plasma after passing into argon gas, and discharge power is 50W, and the treatment time is 3min, is taken out by this interposing catheter after having processed;
S200: the interposing catheter obtained by step S100 is soaked in the acrylic acid aqueous solution of 25wt% concentration and carries out graft modification, grafting temperature is 60 DEG C, grafting time is 12h, react rear taking-up interposing catheter, with deionized water wash several, until the pH value of washing liq no longer changes, afterwards conduit is positioned in vacuum drying oven, takes out after dry 12 hours at 80 DEG C;
S300: the surface above-mentioned priming paint being coated to the interposing catheter that step S200 obtains, solidifies 1h at 60 DEG C;
S400: the interposing catheter obtained to step S300 by above-mentioned top layer paint on the surface, solidifies 1h at 80 DEG C;
S500: the interposing catheter obtained by step S400 is immersed in strong aqua, at room temperature soaks 1h, after taking-up at 60 DEG C dry 12h, the interposing catheter that surface has hydrophilic lubrication coating can be obtained.
Oilness testing method is identical with embodiment one.
After tested, in the present embodiment, interposing catheter friction reduces degree fp-r value higher than 90%.
The above embodiment only have expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but therefore can not be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claim.
Claims (11)
1. an interposing catheter surface treatment method, is characterized in that, comprises the steps:
S100: pre-treatment: Cement Composite Treated by Plasma is carried out to interposing catheter;
S200: modification: will soak in modified solution through pretreated interposing catheter and to take out after certain hour and to carry out carrying out washing treatment and drying treatment;
S300: apply the first coating: priming paint be coated to the surface of the interposing catheter that step S200 obtains and solidify;
S400: apply the second coating: the interposing catheter surface obtained to step S300 by top layer paint is also solidified;
S500: aftertreatment: the interposing catheter obtained by step S400 immerses in strong aqua, carries out drying treatment after taking-up.
2. interposing catheter surface treatment method according to claim 1, it is characterized in that, Cement Composite Treated by Plasma described in step S100 is be placed on by interposing catheter in the sample chamber of plasma body generator, plasma treatment is carried out after passing into gas, wherein discharge power is 10W to 300W, and the treatment time is 1min to 5min.
3. interposing catheter surface treatment method according to claim 2, is characterized in that, described gas is one or more in helium, argon gas, oxygen and nitrogen.
4. interposing catheter surface treatment method according to claim 1, it is characterized in that, in step S200, described modified solution is acrylic acid aqueous solution, the mass percent concentration of wherein said acrylic acid aqueous solution is 5% to 95%, temperature is 30 DEG C to 90 DEG C, and the soak time of interposing catheter is 2h to 24h.
5. interposing catheter surface treatment method according to claim 1, is characterized in that, the drying temperature of the drying treatment in step S200 is 75 DEG C to 85 DEG C, and time of drying is 10h to 14h.
6. interposing catheter surface treatment method according to claim 1, it is characterized in that, the preparation method of described priming paint is: by aqueous polyurethane, polyfunctionality aziridine derivative, Siloxane-Oxyalkylene Copolymers and deionized water are added in container, at room temperature stir 25 minutes to 35 minutes, priming paint can be obtained, the quality of wherein said polyfunctionality aziridine derivative is 1% ~ 10% of described aqueous polyurethane quality, the quality of described Siloxane-Oxyalkylene Copolymers is 0.05% ~ 0.15% of described aqueous polyurethane quality, the quality of described deionized water is 80% ~ 99% of priming paint total mass.
7. interposing catheter surface treatment method according to claim 6, it is characterized in that, described polyfunctionality aziridine derivative is one or more in TriMethylolPropane(TMP)-three [3-(2-methylaziridine base)] propionic ester, TriMethylolPropane(TMP)-three (3-'-aziridino) propionic ester and tetramethylolmethane-three (3-'-aziridino) propionic ester.
8. interposing catheter surface treatment method according to claim 1, it is characterized in that, the preparation method of described top layer coating is: be added in container by polymethyl vinyl ether-maleic anhydride, poly glycol monomethyl ether and organic solvent, at room temperature stir 25 minutes to 35 minutes, top layer coating can be obtained, wherein the quality of poly glycol monomethyl ether is 1% ~ 20% of polymethyl vinyl ether-maleic anhydride quality, and the quality of organic solvent is 80% ~ 99% of top layer coating total mass.
9. interposing catheter surface treatment method according to claim 8, it is characterized in that, described organic solvent is N, dinethylformamide, N, one or more in N-N,N-DIMETHYLACETAMIDE, N-Methyl pyrrolidone, N, N-dimethyl sulfoxide (DMSO), ethyl acetate, N-BUTYL ACETATE, methylene dichloride, trichloromethane, acetone, butanone and tetrahydrofuran (THF).
10. interposing catheter surface treatment method according to claim 1, is characterized in that, the solidification value in step S300 is 55 DEG C to 65 DEG C, and set time is 0.8h to 1.2h; Solidification value in step S400 is 75 DEG C to 85 DEG C, and set time is 0.8h to 1.2h; The immersion time in step S500 is 0.9h to 1.3h, and drying temperature is 55 DEG C to 70 DEG C, and time of drying is 11h to 13h.
11. 1 kinds of interposing catheters, comprise catheter main body, it is characterized in that, the surface of described catheter main body adopts the interposing catheter surface treatment method described in any one of claim 1 to 10 to process.
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| CN201510038107.XA CN104558666B (en) | 2014-03-20 | 2015-01-26 | Interposing catheter surface treatment method and interposing catheter |
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| WO2020155746A1 (en) * | 2019-02-02 | 2020-08-06 | 江苏百赛飞生物科技有限公司 | Ureter stent and manufacture method therefor |
| CN113164656A (en) * | 2018-11-16 | 2021-07-23 | 心脏起搏器股份公司 | Lubricating silicone resin |
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| CN104771789B (en) * | 2014-08-26 | 2017-09-29 | 江苏坤宇集团有限公司 | A kind of antibiotic medical catheter and preparation method thereof |
| CN104225687A (en) * | 2014-09-23 | 2014-12-24 | 北京迪玛克医药科技有限公司 | Paint for intervention duct and preparation method thereof, and intervention duct |
| CN104307051B (en) * | 2014-10-30 | 2015-12-30 | 北京迪玛克医药科技有限公司 | Hydrophilic coating and preparation method thereof and intervention apparatus |
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| CN105983139A (en) * | 2015-02-11 | 2016-10-05 | 北京迪玛克医药科技有限公司 | Method for manufacturing hydrophilic lubricating coating on surface of medical interventional catheter |
| CN105985721B (en) * | 2015-02-11 | 2018-02-16 | 北京迪玛克医药科技有限公司 | A kind of coating and its preparation and application for forming catheter surface hydrophilic coating |
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| CN107261297A (en) * | 2017-08-01 | 2017-10-20 | 郑州大学第附属医院 | The interposing catheter of multistage controlled deflection |
| CN113633832A (en) * | 2021-08-03 | 2021-11-12 | 广州维力医疗器械股份有限公司 | Method for manufacturing ureteral stent anti-crusting coating based on anionic resin |
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