CN203861633U - Expansion sacculus with modified coating on surface - Google Patents
Expansion sacculus with modified coating on surface Download PDFInfo
- Publication number
- CN203861633U CN203861633U CN201420221480.XU CN201420221480U CN203861633U CN 203861633 U CN203861633 U CN 203861633U CN 201420221480 U CN201420221480 U CN 201420221480U CN 203861633 U CN203861633 U CN 203861633U
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- CN
- China
- Prior art keywords
- sacculus
- modified coating
- coating
- medicine
- expansion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000011248 coating agent Substances 0.000 title claims abstract description 44
- 238000000576 coating method Methods 0.000 title claims abstract description 44
- 229920000642 polymer Polymers 0.000 claims abstract description 13
- 239000000463 material Substances 0.000 claims abstract description 7
- 230000000916 dilatatory effect Effects 0.000 claims description 20
- 239000000178 monomer Substances 0.000 claims description 10
- 230000001413 cellular effect Effects 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 3
- 229920000193 polymethacrylate Polymers 0.000 claims description 3
- 239000003814 drug Substances 0.000 abstract description 24
- 238000000034 method Methods 0.000 abstract description 7
- 208000037803 restenosis Diseases 0.000 abstract description 5
- 239000011148 porous material Substances 0.000 abstract description 3
- 206010020718 hyperplasia Diseases 0.000 abstract description 2
- 231100000915 pathological change Toxicity 0.000 abstract description 2
- 230000036285 pathological change Effects 0.000 abstract description 2
- 229920002521 macromolecule Polymers 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 13
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 8
- 229940079593 drug Drugs 0.000 description 8
- 239000003361 porogen Substances 0.000 description 8
- 238000006116 polymerization reaction Methods 0.000 description 6
- 239000003431 cross linking reagent Substances 0.000 description 5
- 238000005286 illumination Methods 0.000 description 5
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical group FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 description 4
- VLCAYQIMSMPEBW-UHFFFAOYSA-N methyl 3-hydroxy-2-methylidenebutanoate Chemical group COC(=O)C(=C)C(C)O VLCAYQIMSMPEBW-UHFFFAOYSA-N 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 208000007536 Thrombosis Diseases 0.000 description 3
- 210000004351 coronary vessel Anatomy 0.000 description 3
- 208000024172 Cardiovascular disease Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010027336 Menstruation delayed Diseases 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- 238000013019 agitation Methods 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- HPXRVTGHNJAIIH-UHFFFAOYSA-N cyclohexanol Chemical compound OC1CCCCC1 HPXRVTGHNJAIIH-UHFFFAOYSA-N 0.000 description 2
- 229960000935 dehydrated alcohol Drugs 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- VFHVQBAGLAREND-UHFFFAOYSA-N diphenylphosphoryl-(2,4,6-trimethylphenyl)methanone Chemical group CC1=CC(C)=CC(C)=C1C(=O)P(=O)(C=1C=CC=CC=1)C1=CC=CC=C1 VFHVQBAGLAREND-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000007654 immersion Methods 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000004506 ultrasonic cleaning Methods 0.000 description 2
- KKJUPNGICOCCDW-UHFFFAOYSA-N 7-N,N-Dimethylamino-1,2,3,4,5-pentathiocyclooctane Chemical compound CN(C)C1CSSSSSC1 KKJUPNGICOCCDW-UHFFFAOYSA-N 0.000 description 1
- 208000037260 Atherosclerotic Plaque Diseases 0.000 description 1
- SXNICUVVDOTUPD-UHFFFAOYSA-N CC1=CC(C)=CC(C)=C1C(=O)P(=O)C1=CC=CC=C1 Chemical compound CC1=CC(C)=CC(C)=C1C(=O)P(=O)C1=CC=CC=C1 SXNICUVVDOTUPD-UHFFFAOYSA-N 0.000 description 1
- 229920002614 Polyether block amide Polymers 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000003618 dip coating Methods 0.000 description 1
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 1
- 210000003725 endotheliocyte Anatomy 0.000 description 1
- 238000010109 expendable mold casting Methods 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 210000003695 paranasal sinus Anatomy 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 235000021395 porridge Nutrition 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 230000000250 revascularization Effects 0.000 description 1
- 238000007788 roughening Methods 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000004026 tunica intima Anatomy 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
The utility model discloses an expansion sacculus with a modified coating on the surface. The expansion sacculus comprises a sacculus body and the modified coating, wherein the sacculus is made from a macromolecule material; the modified coating is made from a non-water-soluble high-molecular polymer; during use, the expansion sacculus can ensure that medicine is firmly attached to and loaded on coating external surface on the periphery of the sacculus as well as pores of the porous structure thereof, so as to increase initial medicine load, reduce medicine loss in the delivery process of the sacculus, ensure that sufficient medicine is released at the pathological position in the expansion process of the sacculus, better improve the performance of preventing and treating restenosis, intimal hyperplasia and other pathological changes of the vessel expansion sacculus.
Description
Technical field
This utility model relates to medical dilating sacculus, refers in particular to a kind of balloon surface with the dilating sacculus of the modified coating of the cellular hole structure of nanoscale/micron order.
Background technology
It is one of most effectual way of cardiovascular disease myocardial revascularization that application percutaneous coronary artery intervention (percutaneons coronary intervention, PCI) is implanted into support in narrow arteria coronaria.But after implant frame, because support expansion is to tearing of tunica intima and breaking and the outflow of medicated porridge sample material of lesion atheromatous plaque, all may cause acute, the subacute stent thrombosis in early days of secondary to form and the in-stent restenosis in late period, oneself becomes percutaneous coronary artery intervention and treats main bugbear in the urgent need to address.
The appearance of medicine coating blood vessel support (durg eluting sent, DES) reduces the In-stent Restenosis rate that hamartoplasia causes greatly, is the another huge advance made in treating cardiovascular disease field.But clinical effectiveness analysis for many years shows, still there are some serious problems in this technology, in a large number about the mortality complication of DES thrombus in stents and late period Restenosis etc. report continue to bring out, the generation that people especially may increase death or advanced thrombus to the safety of DES is particularly worried.
In recent years, along with research deepen continuously and perfect, based on medicine-coated balloon (drug coated balloon, DCB) new technique is the emerging means for intracavitary therapy, the endothelialization obstacle that it has avoided sustained drug contact to cause, a current study hotspot that becomes just gradually coronary intervention field.Yet, existing medicine-coated balloon, its shortcoming is balloon body smooth surface, and the adhesion between coating medicine is little, medicine load-carry duty is low, after medicine-coated balloon conduit implantable intravascular, be subject to washing away of unidirectional blood flow, medicine is lost in course of conveying in blood more, to such an extent as to the active drug of arrival target vessel is less, thereby has limited the curative effect of medical balloon.
Utility model content
The technical problems to be solved in the utility model is for above-mentioned the deficiencies in the prior art, and a kind of ingenious, simple surperficial dilating sacculus with modified coating of technique that designs is provided.
The technical scheme that this utility model is taked is as follows: a kind of surface, with the dilating sacculus of modified coating, comprises sacculus body and modified coating, and wherein, above-mentioned sacculus body is macromolecular material, and modified coating is water-insoluble macromolecular polymer.
Preferably, described water-insoluble macromolecular polymer is polymethacrylate compound monomer.
Preferably, the thickness of described modified coating is 0.05-0.3 μ m.
Preferably, described modified coating is cellular porous structure, and the porosity of above-mentioned loose structure is at 40-60%.
The beneficial effects of the utility model are:
Dilating sacculus of the present utility model includes but not limited to peripheral blood vessel dilating sacculus (PTA), coronary artery sacculus (PTCA), vertebral body expanding balloon (Balloon Kyphoplasty), float catheter sacculus (Swan-Ganz), nasal sinuses sacculus (Balloon Sinuplasty), the sacculus such as eyelid sacculus (Dacrocystography).Particularly, method by the polymerization of UV illumination trigger monomer is prepared the modified coating of one deck water-insoluble macromolecular polymer at sacculus body surface, it is characterized in that, this modified coating has the loose structure compared with large roughness, can guarantee that medicine adheres to securely and loads in the coating outer surface of sacculus body periphery and the hole of loose structure thereof, increase initial drug load capacity and reduce the loss of sacculus delivery process Chinese medicine, to guarantee sufficient medication amount can be discharged into diseased region when the balloon expandable, by endotheliocyte, absorbed, realize target administration, thereby reach the effect for the treatment of.
Adopt surface that preparation technology of the present utility model obtains with the dilating sacculus of modified coating, microcellular structure is modified to dilating sacculus surface applications in balloon surface medication coat, form the modified coating of cellular porous structure, the modified coating of this kind of structure can guarantee that medicine adheres to securely and is carried in the coating outer surface of sacculus body periphery and the hole of loose structure thereof in use, increase initial drug load capacity and reduce the loss of sacculus delivery process Chinese medicine, thereby guaranteeing has sufficient medication amount to be discharged into diseased region in balloon expandable process, thereby improve better Angiectasis sacculus control restenosis, the performance of the pathological changes such as neointimal hyperplasia.
Accompanying drawing explanation
Fig. 1 is the cross-sectional view of this utility model dilating sacculus.
Fig. 2 is the optics Electronic Speculum figure of traditional dilating sacculus.
Fig. 3 is the optics Electronic Speculum figure of this utility model dilating sacculus.
The specific embodiment
Below in conjunction with accompanying drawing, this utility model is further described:
As shown in Figure 1 to Figure 3, the technical scheme that this utility model is taked is as follows: a kind of surface, with the dilating sacculus of modified coating, is characterized in that: comprise sacculus body 1 and modified coating 2, wherein, above-mentioned sacculus body 1 is macromolecular material, and modified coating 2 is water-insoluble macromolecular polymer.
Preferably, nylon material or Pebax material that described sacculus body 1 is known for this research field personnel, not affecting under the physics and chemistry of balloon material and the prerequisite of mechanical property, modify its surface, make it roughening, improved adhesion and load-carry duty for medicine.
Preferably, described water-insoluble macromolecular polymer is polymethacrylate compound monomer.
Preferably, the thickness of described modified coating 2 is 0.05-0.3 μ m, is preferably 0.1 μ m.
Preferably, described modified coating 2 is cellular porous structure, and the porosity of above-mentioned loose structure is at 40-60%.
A kind of surface is with the preparation technology of the dilating sacculus of modified coating, it is characterized in that comprising the following steps: the preparation of the pretreatment on a, sacculus body 1 surface, b, coating solution, c, surface-coated, d, UV illumination initiated polymerization, e, solvent wash pore, f, cold drying, wherein:
The pretreatment on a, sacculus body 1 surface: mixed liquor (1:1) ultrasonic cleaning 10～20 min that sacculus body 1 put into dehydrated alcohol and water, remove surface impurity, then use deionized water rinsing, put into drying baker, Temperature Setting, at 50～70 ℃, takes out standby after dry 1～2 h;
The preparation of b, coating solution: prepared polymer monomer, cross-linking agent, light trigger and porogen solution in proportion, by above-mentioned mixed solution magnetic agitation 1～2 h mix homogeneously, obtain coating solution;
C, surface-coated: by the coating solution of step b gained, the mode by automatically electrostatic spray is coated in sacculus body 1 surface equably;
D, UV illumination initiated polymerization: by the sacculus applying in step c, being placed in intensity is 36.0 mw/cm
2ultraviolet lighting under initiated polymerization 5～10 minutes;
E, solvent wash pore: the sacculus of processing in steps d is soaked in to supersound washing 1～2 h or washing by soaking 1～2 h in acetone soln, removes unreacted polymer solution and porogen completely, then, with acetone soln, repeatedly clean sacculus;
F, cold drying: the sacculus after cleaning is dried to 30～60 minutes at the temperature of 30～50 ℃, can obtains surface with the dilating sacculus of modified coating.
Preferably, in above-mentioned steps b, described polymer monomer is hydroxyethyl methylacrylate (HEMA); Described cross-linking agent is ethylene glycol dimethacrylate (EDMA); Described light trigger is TMDPO (TPO); Described porogen is lauryl alcohol or Hexalin or the combination of the two, and the content of porogen is 30%～70%.
Preferably; in above-mentioned steps b; the configuration proportion of described polymer monomer, cross-linking agent, light trigger and porogen solution is: hydroxyethyl methylacrylate: ethylene glycol dimethacrylate=2:1; 2; 4; 6-trimethylbenzoyl diphenyl phosphine oxide accounts for 0.3%～0.5% of monomer and cross-linking agent gross mass, and the content of porogen is 30%～70%.
Preferably, in above-mentioned steps c, surface-coated or for sacculus body 1 is immersed in coating solution, the immersion time is 10～20 s, then by sacculus, the speed with 6～10 cm/min lifts out from solution, and repetitive operation is once or repeatedly.
Particularly, nylon balloons is put into mixed liquor (1:1) ultrasonic cleaning 20 min of dehydrated alcohol and water, removed surface impurity, then use a large amount of deionized water rinsings, put into drying baker, Temperature Setting, at 60 ℃, takes out standby after dry 1 h.
By monomer hydroxyethyl methylacrylate 4 ml, cross-linking agent ethylene glycol dimethacrylate 2 ml, light trigger phenyl (2,4,6-trimethylbenzoyl) phosphine oxide 0.0255 g (0.4%), and porogen Hexalin 14 ml put into beaker and are made into coating solution, magnetic agitation 1 h at room temperature; The sacculus that cleaning treatment is crossed is manually immersed in coating solution, and the immersion time is 20 s, then lifts out from solution with the speed of 6 cm/min, repeats this operation once after 10 min; Then the sacculus of dip-coating is placed in to trigger monomer polymerization under UV illumination, intensity of illumination is 36.0 mw/cm
2, light application time is
10min; After polymerization completes, sacculus is soaked in to supersound washing 2 h in acetone soln, removes unreacted polymer solution and porogen completely, and repeatedly clean sacculus with a large amount of acetone solns.Finally sacculus is placed in to dry 1 h at 30 ℃, can obtains the dilating sacculus that surface possesses loose structure.
Embodiment of the present utility model just introduces its specific embodiment, does not lie in and limits its protection domain.The technical staff of the industry can make some and revise under the inspiration of the present embodiment, and the equivalence of doing according to this utility model the scope of the claims therefore all changes or modifies, and all belongs within the scope of this utility model Patent right requirement.
Claims (4)
1. surface, with a dilating sacculus for modified coating, is characterized in that: comprise sacculus body (1) and modified coating (2), wherein, above-mentioned sacculus body (1) is macromolecular material, and modified coating (2) is water-insoluble macromolecular polymer.
2. a kind of surface according to claim 1, with the dilating sacculus of modified coating, is characterized in that: described water-insoluble macromolecular polymer is polymethacrylate compound monomer.
3. a kind of surface according to claim 1, with the dilating sacculus of modified coating, is characterized in that: the thickness of described modified coating (2) is 0.05-0.3 μ m.
4. a kind of surface according to claim 1, with the dilating sacculus of modified coating, is characterized in that: described modified coating (2) is cellular porous structure, and the porosity of above-mentioned loose structure is at 40-60%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420221480.XU CN203861633U (en) | 2014-05-04 | 2014-05-04 | Expansion sacculus with modified coating on surface |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420221480.XU CN203861633U (en) | 2014-05-04 | 2014-05-04 | Expansion sacculus with modified coating on surface |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203861633U true CN203861633U (en) | 2014-10-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201420221480.XU Expired - Lifetime CN203861633U (en) | 2014-05-04 | 2014-05-04 | Expansion sacculus with modified coating on surface |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203861633U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948972A (en) * | 2014-05-04 | 2014-07-30 | 广东博迈医疗器械有限公司 | Expandable saccule provided with modified coating on surface and preparation process of expandable saccule |
| CN113144376A (en) * | 2021-04-16 | 2021-07-23 | 上海市胸科医院 | Nano double-resistance deep venous catheter |
| CN117982777A (en) * | 2024-04-03 | 2024-05-07 | 万漉医疗科技(江苏)有限公司 | Guide wire system with sacculus |
-
2014
- 2014-05-04 CN CN201420221480.XU patent/CN203861633U/en not_active Expired - Lifetime
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948972A (en) * | 2014-05-04 | 2014-07-30 | 广东博迈医疗器械有限公司 | Expandable saccule provided with modified coating on surface and preparation process of expandable saccule |
| CN113144376A (en) * | 2021-04-16 | 2021-07-23 | 上海市胸科医院 | Nano double-resistance deep venous catheter |
| CN113144376B (en) * | 2021-04-16 | 2024-03-29 | 上海市胸科医院 | Nanometer double-resistance deep vein catheter |
| CN117982777A (en) * | 2024-04-03 | 2024-05-07 | 万漉医疗科技(江苏)有限公司 | Guide wire system with sacculus |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address |
Address after: 523000 Room 301, building 15, No.1, North 4th Industrial Road, Songshanhu Park, Dongguan City, Guangdong Province Patentee after: Guangdong Bomai Medical Technology Co.,Ltd. Address before: 523000 3rd floor, building 15, small and medium-sized science and technology enterprise Pioneer Park, northern industrial city, Songshanhu high tech Industrial Development Zone, Dongguan City, Guangdong Province Patentee before: GUANGDONG BROSMED MEDICAL DEVICE Co.,Ltd. |
|
| CP03 | Change of name, title or address | ||
| CX01 | Expiry of patent term |
Granted publication date: 20141008 |
|
| CX01 | Expiry of patent term |